CN108782604A - A kind of fungicide and its application - Google Patents
A kind of fungicide and its application Download PDFInfo
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- CN108782604A CN108782604A CN201710324594.5A CN201710324594A CN108782604A CN 108782604 A CN108782604 A CN 108782604A CN 201710324594 A CN201710324594 A CN 201710324594A CN 108782604 A CN108782604 A CN 108782604A
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- Prior art keywords
- fungicide
- selenite
- food
- containing selenium
- sodium selenite
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/358—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Dentistry (AREA)
- Epidemiology (AREA)
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- Veterinary Medicine (AREA)
- Agronomy & Crop Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The fungicide of the present invention and its purpose of application are the inhibiting effect for utilizing selenite or organic matter containing selenium or other reducing agents containing selenium to the microorganisms energy metabolism such as mushroom, so that the growth of microorganism is suppressed, achievees the purpose that food fresh keeping anti-corrosion and sanitation and hygiene and medical Relative Fungi, mycotic disease.Make selenite or organic matter containing selenium as one of the active ingredient of fungicide or active ingredient, becomes the fungicide product of the reducing agent containing selenium.
Description
Technical field
The present invention relates to a kind of fungicide and its application, it is related to that food antiseptic is fresh-keeping, personal cleanliness is hygienic, medical field.
Background technology
It is well known that the selenium of reproducibility or reducing agent containing selenium (sodium selenite, organic acid containing selenium, Selenonic protein etc.) are to tumour
With preventive and therapeutic action, but its mechanism is never explicitly analyzed and explanation.It is in view of tumour cell obtains energy
By glycolytic cycle, and normal cell is then by aerobic oxidation, and in view of the reproducibility of selenium, from redox reaction
Angle analysis, it should it is concluded that and obtain be widely applied effect.
It is pyruvic acid, the process of ATP and NADH+H+ that glycolysis, which refers to by glucose or decomposition of glycogen,.Under anoxic conditions
Pyruvic acid can then receive the hydrogen that triose phosphate is taken off, be reduced to lactic acid under the catalysis of lactic dehydrogenase.And under aerobic conditions
Sugar oxygenolysis, referred to as sugared aerobic oxidation, pyruvic acid further oxygenolysis can generate acetyl-CoA and enter tricarboxylic acids and follow
Ring generates CO2 and H2O.Many steps of the aerobic oxidation and glycolysis of sugar in the incipient stage are duplicate, are only decomposed
After pyruvic acid, due to the different just disagreement of oxygen supply condition.
Glycolysis includes in total 10 consecutive steps, by corresponding enzymatic.Overall reaction is：
Glucose+2ATP+2ADP+2Pi+2NAD+ --->2 pyruvic acid+4ATP+2NADH+2H+
Pyruvic acid (CH3COCOOH)+NADH+H+- is reversible->Lactic acid (CH3CHOHCOOH)+NAD+
Specifically, two important redox reactions involved during tumour cell glycometabolism to lactic acid are：
(1) glyceraldehyde 3-phosphate+phosphoric acid+NAD+ → 1,3- diphosphoglyceric acid+NADH+ H+
And
(2) pyruvic acid+NADH+H+ → lactic acid+NAD+
Wherein, NAD+ and NADH can be recycled and be generated as catalyst, ensure that the sustainability of metabolism.
In the presence of sodium selenite, the available following chemical formula of reproducibility reaction of sodium selenite indicates：
Na2SeO3 (strong reducing property)+H2O--->Na2SeO4 (stable compound)+2H (atom state hydrogen)
(other reducing agents containing selenium have the similar reaction for providing hydrogen)
For reaction (1), sodium selenite is as reducing agent (antioxidant), with the same substrate 3- phosphoric acid as reducing agent
Glyceraldehyde competes, and following redox reaction may occur respectively：
A, sodium selenite+H2O+NAD+ → NADH+H++sodium selenate
B, glyceraldehyde 3-phosphate+phosphoric acid+NAD+ → 1,3- diphosphoglyceric acid+NADH+ H+
Chemically free energy of reaction variation judges that reaction (b) should be much larger than reaction from aldehyde to the driving energy of the reaction of acid
(a), therefore, reaction (1) is smaller by being influenced existing for sodium selenite, avoid or reduces sodium selenite to normal cell metabolism
Interference effect；Or sodium selenite is competed as reducing agent and the same substrate glyceraldehyde 3-phosphate as reducing agent, is urged in enzyme
In the specific reaction of change, sodium selenite or reducing agent containing selenium are not engaged in the advantage of reaction.
For reaction (2), sodium selenite as reducing agent directly be equally that the NADH coenzyme of reducing agent competes, without
It is to be competed with substrate pyruvate.If pyruvic acid receives the hydrogen provided from sodium selenite reduction reaction, then NADH can not be converted into
NAD+；Or pyruvic acid still can receive the hydrogen from NADH, and NADH is made to be converted into NAD+, but NAD+ can immediately with sub- selenium
The atom state hydrogen that sour sodium reduction reaction provides, which combines, forms NADH, it is therefore intended that because being unable to get reaction (1) in glycolysis chain
Required NAD+ and the failure for leading to tumour cell glycometabolism are played and inhibit growth of tumour cell, promote apoptosis of tumor cells
Effect.
Invention content
A kind of fungicide of the present invention and its purpose of application are to utilize selenite or organic matter containing selenium or other containing selenium
Reducing agent makes the growth of microorganism be suppressed the inhibiting effect of the microorganisms energy metabolism such as mushroom, reaches food guarantor
The purpose of fresh anti-corrosion and sanitation and hygiene and medical relevant disease, i.e. selenite or organic matter containing selenium is as the effective of fungicide
One of ingredient or active ingredient become the fungicide product of the reducing agent containing selenium.
The present invention food sterilization antisepsis antistaling agent purpose be to provide it is a kind of low cost, efficiently and can be beneficial to human body
Food preservative freshness retaining agent achievees the purpose that substitute harmful or of high cost existing food preservative freshness retaining agent.Selenium element is
The necessary trace element of human body can not only give human body to supplement necessary trace element, but also can reach food using sodium selenite
The purpose of anti-corrosive fresh-keeping, avoids that harmless preservative is of high cost, and inexpensive preservative is often harmful
Problem.
The food sterilization antisepsis antistaling agent of the present invention, is that micro sodium selenite or selenite are added in food, especially
It is more effective in the case where completely cutting off air.Because the corruption of food also has the corruption that oxidation effect of food itself is incurred,
Inoxidizability based on sodium selenite or selenite exposes aerial food in the presence of sodium selenite,
Oxydative spoilage speed can also lower, to achieve the purpose that extend the food shelf-life.Likewise, the food antiseptic of the present invention is fresh-keeping
Agent is suitably applied in the food productions processing such as the marinated of food, sauced, molding, canned, packed, bottled.
The sterilizing cleaning sunitizing of the present invention is that sodium selenite or selenite are added in aqueous solution or in detergent,
As the clean environments sanitary disinfecting agent such as kitchen, lavatory, anaerobism mushroom is especially killed, or inhibit fungus grown, make microorganism
Aerobic oxidation can only be carried out, the generation of toxin is reduced.
The sterilization medical preparation of the present invention, is added in acetic acid or alcohol or aqueous solution or other solution or paste
Sodium selenite or selenite or reducing agent containing selenium, as external medical sanitary disinfecting agent, or with spray, mouthwash mode makes
With especially killing anaerobism mushroom, or inhibition fungus grown makes microorganism that can only carry out aerobic oxidation, reduces the generation of toxin.
The various diseases phenomenon including but not limited to caused by bacterial micro-organism, as onychomycosis, skin moss, scalp mould, mycotic venereal disease,
The skin surfaces mycotic such as underarm odor disease, fungoid rhinitis, periodontitis, oral inflammation, respiratory tract mould, Pulmonary Fungal Infections
Treatment etc..
The present invention fungicide and its application, it is contemplated that cause the common microbiological of food spoilage be bacterium, saccharomycete and
The mushrooms such as mould, and the mushroom microorganism on environment or body in Different Organs is colonized in, although the title difference of microorganism,
Residing organ site is different, caused by lesion result it is different, but the energetic supersession of mushroom is also via the aerobic oxidation of sugar or sugared ferment
Solution preocess.The corruption of the anti-corrosive fresh-keeping of food in sealed states, food is mainly that anaerobic fermentation process, that is, mushroom etc. are micro-
Growth and breeding process of the biology under anaerobic condition；Likewise, colonizing in the microorganisms such as the mushroom in human body Different Organs
Energy is obtained via the process of aerobic oxidation or glycolysis.Pyruvic acid involved by the process to lactic acid metabolic process and tumour
The metabolic process of cell is consistent, and therefore, sodium selenite or reducing agent containing selenium can equally inhibit to eat to the inhibiting effect of tumour cell
Corruption, pathogenic bacteria etc. can obtain the growth and breeding of the bacterial micro-organism of energy via glycolysis in product, inside and outside human body, from
And achievees the purpose that food is anti-corruption fresh-keeping and treat the lesion caused by the microorganisms such as mushroom.
The fungicide of the present invention and its application, because selenium reducing agent acts on tumour cell or bacterial cell obtains energy
The step for redox chemistry of pyruvic acid to lactic acid reacts, chemical reaction or non-genomic with genes within cells control control
Non-oxide reduction reaction process without directly chemical interrelating effect, therefore do not have because of genetic mutation, and cause selenium also
The problem of former agent fails or develops immunity to drugs.In other words, be specific path that gene controls cell metabolism, gene there are few
Variation ability exhausted provides for the metabolism of cell (including medication environment) under circumstances and various backs up selection
Path, therefore the problem of cell just has drug resistance, but the metabolic response of pyruvic acid to lactic acid is the necessary path of glycolysis, no
By gene regulation, therefore, cures the disease by the function and effect sterilization of the reducing agent containing selenium, there is no the problem of drug resistance；Or it can force swollen
Oncocyte or bacterial micro-organism switch to obtain energy by aerobic oxidation process, make tumour cell transformation be normal cell, make carefully
Bacteria microorganism does not generate all kinds of harmful toxin because of Anaerobic respiration processes.
Specific implementation mode
Embodiment 1
In order to verify effect of the sodium selenite to food antiseptic, it will be symmetrically cut into two panels with a piece of leaf lettuce, size is big
Small is 2x2 centimetres, is respectively put into the beaker for the tap water for filling 80g, it is micro- that in terms of selenium 180 are additionally incorporated in one of beaker
Gram sodium selenite, selenium concentration about 2.3ppm.Experiment finds that room temperature is containing the molten of sodium selenite about at 15-20 DEG C
Leaf lettuce in liquid was up to the 5th day, and the brown corruption spot of diameter about 1mm just occurs in surface, but not plus in sodium selenite solution
The strip brown plaque of a diameter about 6mm round spot and an about 1x4mm is formd on leaf lettuce.In addition, containing sub- selenium
Up to the 11st day, the leaf lettuce in the solution for not adding sodium selenite the 5th day occurred because of corruption leaf lettuce in the solution of sour sodium
The ripe and phenomenon that sinks under water.The two panels lettuce that Escherichia coli are vaccinated with liquid dung stalk is respectively put into above-mentioned solution, after 2 days i.e.
It can find, the lettuce stalk edge in the solution without sodium selenite grows white velvet-like bacterium colony, but in containing sodium selenite solution
Lettuce obstruct then without this phenomenon.Thus it all illustrates that sodium selenite inhibits food antiseptic the effect of bacterial growth, also demonstrate,proves indirectly
Inhibition of the sodium selenite to microorganism and tumour cell pyruvic acid to lactic acid metabolism is illustrated.
Using the similar experiment of other plants it has also been found that there is same phenomenon.It particularly finds, molten without sodium selenite
Leaf of Herba Apii graveolentis in liquid shifts to an earlier date yellowing than it in the solution of sodium selenite containing 0.5ppm.
During production application, the characteristics of according to different foods, seasonal characteristic can also be increased or decreased suitably
The dosage of sodium selenite.Because the reproducibility of sodium selenite or other selenites (ammonium salt, sylvite etc.) is lacked for microorganism
Inhibiting effect occurs for the metabolic process under oxygen condition, and therefore, the corrosion-resistanting fresh-keeping effect of selenite should mainly salt down in food
It is effective when system, sauced, molding (such as the rice dumpling, various meatballs, Tofu etc.), canned, packed, bottled production, i.e., substantially every
It is more effective in the case of exhausted air.
Embodiment 2
In order to verify sodium selenite to the therapeutic effect due to skin disease caused by bacterium (such as fungal microbe),
Sodium selenite is added in 75% medical alcohol, is configured to the sodium selenite alcoholic solution of the 20ppm of meter containing selenium.It is smeared with the solution
There is the onychomycosis patient of 3 years, smear daily once, third day finds that toenail becomes relatively normal face from lark
Color.It is coated at 6 years as long as skin moss pruituses with the solution, once a day, pruitus and skin moss symptom, that is, base after 2 weeks
This disappearance.
The pure acetum of analysis for using 5% instead, is configured to the sodium selenite acetum of the 100ppm of meter containing selenium.With the solution
It is coated with body odour history patient, it is just basic on the day of body odour sense to disappear.
It is inferred that mechanism and mechanism based on sodium selenite sterilization, reducing agent containing selenium is as other bacillary, moulds
Property, fungoid rhinitis, oral inflammation, respiratory inflammation, Pulmonary Fungal Infections, treating for skin disease all should be effective；Together
Sample reducing agent containing selenium is also effective as the fungicide in kitchen, toilet.
For convenience of use, fungicide containing selenium can be made into spray, aqua, ethyl alcohol agent, acetic acid agent, various paste or injection
(so that selenium reducing agent is directly transported to tumour or inflammatory sites)；And according to the disease specific spy different at specific illness
Point is increased and decreased in the content and dosage of sodium selenite, and supplement such as ethyl alcohol, acetic acid content can also be increased and decreased.
The above is only presently preferred embodiments of the present invention, any those of ordinary skill in the art, not
It is detached from the range of the carried technical characteristic of the present invention, using disclosed technology contents makes part change or modifies
Equivalent embodiment, and without departing from the technical feature content of the present invention, in the range of still falling within the technology of the present invention feature.
Claims (8)
1. a kind of fungicide, which is characterized in that selenite or organic matter containing selenium as fungicide active ingredient or effectively at
/ mono-, become the fungicide product of the reducing agent containing selenium.
2. fungicide as described in claim 1, the selenite is sodium selenite or ammonium selenite or potassium selenite；Institute
The organic matter containing selenium stated is containing selenoaminoacid or Selenonic protein.
3. a kind of application of fungicide, which is characterized in that it is fresh-keeping applied to food antiseptic that selenium fungicide will be contained；Or applied to cleaning
The sterilization field of health and medical field.
4. the sterilization field of the application of fungicide as claimed in claim 3, the sanitation and hygiene includes but not limited to kitchen
The sanitation and hygiene in room, lavatory.
5. the sterilization field of the application of fungicide as claimed in claim 3, the medical field includes but not limited to, because thin
Various diseases phenomenon caused by bacteria microorganism, such as onychomycosis, skin moss, scalp mould, mycotic venereal disease, underarm odor body surface are all kinds of mould
Bacterium property disease, periodontitis, oral inflammation, respiratory tract or lung mould etc..
6. a kind of food preservative freshness retaining agent, which is characterized in that add micro sodium selenite or selenite in food.
7. food preservative freshness retaining agent as claimed in claim 6, which is characterized in that the fresh-keeping food antiseptic is empty in isolation
It is carried out in the case of gas.
8. food preservative freshness retaining agent as claimed in claim 6, which is characterized in that the food antiseptic is fresh-keeping to be applied to food
Marinated, sauced, molding, canned, packed, bottled production.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710324594.5A CN108782604A (en) | 2017-05-02 | 2017-05-02 | A kind of fungicide and its application |
| EP18787606.5A EP3613417A4 (en) | 2017-04-22 | 2018-04-20 | Method for inhibiting cellular glycolysis process and application thereof |
| CN201880026533.3A CN110545805A (en) | 2017-04-22 | 2018-04-20 | Method for inhibiting cell glycolysis process and application |
| AU2018253749A AU2018253749A1 (en) | 2017-04-22 | 2018-04-20 | Method for inhibiting cellular glycolysis process and application thereof |
| SG11201909854U SG11201909854UA (en) | 2017-04-22 | 2018-04-20 | Method for Inhibiting Both Glycolysis and Glutamine Metabolism in Cells and Use Thereof |
| JP2019558658A JP2020517726A (en) | 2017-04-22 | 2018-04-20 | Method for inhibiting cell glycolysis and use thereof |
| CA3060606A CA3060606A1 (en) | 2017-04-22 | 2018-04-20 | Method for inhibiting glycolysis in cells and use thereof |
| US16/607,353 US20200121716A1 (en) | 2017-04-22 | 2018-04-20 | Method for Inhibiting Both Glycolysis and Glutamine Metabolism in Cells and Use Thereof |
| PCT/CN2018/083952 WO2018192573A1 (en) | 2017-04-22 | 2018-04-20 | Method for inhibiting cellular glycolysis process and application thereof |
| KR1020197034390A KR20190137909A (en) | 2017-04-22 | 2018-04-20 | Method and application of simultaneous inhibition of cell glycolysis and glutamine metabolism |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710324594.5A CN108782604A (en) | 2017-05-02 | 2017-05-02 | A kind of fungicide and its application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108782604A true CN108782604A (en) | 2018-11-13 |
Family
ID=64094474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710324594.5A Pending CN108782604A (en) | 2017-04-22 | 2017-05-02 | A kind of fungicide and its application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108782604A (en) |
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2017
- 2017-05-02 CN CN201710324594.5A patent/CN108782604A/en active Pending
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Application publication date: 20181113 |