SG11201909854UA - Method for Inhibiting Both Glycolysis and Glutamine Metabolism in Cells and Use Thereof - Google Patents
Method for Inhibiting Both Glycolysis and Glutamine Metabolism in Cells and Use ThereofInfo
- Publication number
- SG11201909854UA SG11201909854UA SG11201909854UA SG11201909854UA SG 11201909854U A SG11201909854U A SG 11201909854UA SG 11201909854U A SG11201909854U A SG 11201909854UA SG 11201909854U A SG11201909854U A SG 11201909854UA
- Authority
- SG
- Singapore
- Prior art keywords
- formate
- prevention
- selenite
- inhibiting
- oral administration
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 230000034659 glycolysis Effects 0.000 title abstract 3
- 230000004060 metabolic process Effects 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 title 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 4
- JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 abstract 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 230000001413 cellular effect Effects 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 2
- 235000019253 formic acid Nutrition 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 230000002829 reductive effect Effects 0.000 abstract 2
- 229940082569 selenite Drugs 0.000 abstract 2
- MCAHWIHFGHIESP-UHFFFAOYSA-L selenite(2-) Chemical compound [O-][Se]([O-])=O MCAHWIHFGHIESP-UHFFFAOYSA-L 0.000 abstract 2
- 241000251468 Actinopterygii Species 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 239000004280 Sodium formate Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003064 anti-oxidating effect Effects 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000019688 fish Nutrition 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 229940044170 formate Drugs 0.000 abstract 1
- 229940013688 formic acid Drugs 0.000 abstract 1
- 238000003958 fumigation Methods 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 239000000417 fungicide Substances 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 235000013372 meat Nutrition 0.000 abstract 1
- 229940039748 oxalate Drugs 0.000 abstract 1
- 235000006408 oxalic acid Nutrition 0.000 abstract 1
- 229940116315 oxalic acid Drugs 0.000 abstract 1
- 239000002304 perfume Substances 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 238000006479 redox reaction Methods 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 abstract 1
- 235000019254 sodium formate Nutrition 0.000 abstract 1
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 abstract 1
- 229940039790 sodium oxalate Drugs 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
Classifications
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- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
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- A—HUMAN NECESSITIES
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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Abstract
A method for inhibiting a cellular glycolysis process and an application thereof. The method is using reductive selenium dioxide, selenite or formic acid, formate, oxalic acid, oxalate, sulfur- containing reducing agent, and the like to inhibit a hydrogen cyclic process required in a redox reaction in the cellular glycolysis process. The application comprises : tumor prevention and treatment by applying different reducing agents by means of injection, oral administration, external application, spraying, or fumigation; prevention and treatment of digestive tract inflammation and tumors by means of oral administration; inhibition of a metabolic process of anaerobes and facultative anaerobes, where the reductive selenium dioxide, selenite, formic acid, formate, and the like are used as one of the active ingredients or ingredients of a fungicide; and disease prevention and antioxidation of fresh goods, food, fish and meat, vegetables and fruits, natural perfume, natural cosmetics, detergents, skin care products, and daily sanitary products, maintaining of human redox equilibrium, preservation and fresh-keeping, or related health care field. Problem caused by acidity of the body fluid can be solved by using alkaline sodium carbonate, which is the product of sodium formate and sodium oxalate after metabolism.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710285989.9A CN108719742A (en) | 2017-04-22 | 2017-04-22 | A kind of food preservative freshness retaining agent |
CN201710324594.5A CN108782604A (en) | 2017-05-02 | 2017-05-02 | A kind of fungicide and its application |
CN201710740788.3A CN109394780A (en) | 2017-08-17 | 2017-08-17 | A kind of method and application inhibiting cell glycolytic cycle |
CN201710956579.2A CN109549952A (en) | 2017-09-27 | 2017-09-27 | A kind of method and application inhibiting cell glycolytic cycle |
PCT/CN2018/083952 WO2018192573A1 (en) | 2017-04-22 | 2018-04-20 | Method for inhibiting cellular glycolysis process and application thereof |
Publications (1)
Publication Number | Publication Date |
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SG11201909854UA true SG11201909854UA (en) | 2019-11-28 |
Family
ID=63855546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201909854U SG11201909854UA (en) | 2017-04-22 | 2018-04-20 | Method for Inhibiting Both Glycolysis and Glutamine Metabolism in Cells and Use Thereof |
Country Status (9)
Country | Link |
---|---|
US (1) | US20200121716A1 (en) |
EP (1) | EP3613417A4 (en) |
JP (1) | JP2020517726A (en) |
KR (1) | KR20190137909A (en) |
CN (1) | CN110545805A (en) |
AU (1) | AU2018253749A1 (en) |
CA (1) | CA3060606A1 (en) |
SG (1) | SG11201909854UA (en) |
WO (1) | WO2018192573A1 (en) |
Families Citing this family (1)
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DE10357301A1 (en) * | 2003-12-05 | 2005-07-07 | Schebo Biotech Ag | Compounds for the modulation of the glycolysis enzyme and / or transaminase complex |
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US11369588B2 (en) * | 2014-03-20 | 2022-06-28 | The Trustees Of Princeton University | NADPH production by the 10-formyl-THF pathway, and its use in the diagnosis and treatment of disease |
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2018
- 2018-04-20 SG SG11201909854U patent/SG11201909854UA/en unknown
- 2018-04-20 CA CA3060606A patent/CA3060606A1/en active Pending
- 2018-04-20 US US16/607,353 patent/US20200121716A1/en not_active Abandoned
- 2018-04-20 JP JP2019558658A patent/JP2020517726A/en active Pending
- 2018-04-20 AU AU2018253749A patent/AU2018253749A1/en not_active Abandoned
- 2018-04-20 WO PCT/CN2018/083952 patent/WO2018192573A1/en active Application Filing
- 2018-04-20 KR KR1020197034390A patent/KR20190137909A/en not_active Application Discontinuation
- 2018-04-20 CN CN201880026533.3A patent/CN110545805A/en active Pending
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AU2018253749A1 (en) | 2019-11-14 |
WO2018192573A1 (en) | 2018-10-25 |
CN110545805A (en) | 2019-12-06 |
EP3613417A1 (en) | 2020-02-26 |
EP3613417A4 (en) | 2021-06-09 |
CA3060606A1 (en) | 2018-10-25 |
JP2020517726A (en) | 2020-06-18 |
US20200121716A1 (en) | 2020-04-23 |
KR20190137909A (en) | 2019-12-11 |
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