CN108739813B - Bactericidal composition containing tetrachlorophthalide and pefurazoate and application thereof - Google Patents
Bactericidal composition containing tetrachlorophthalide and pefurazoate and application thereof Download PDFInfo
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- CN108739813B CN108739813B CN201810924794.9A CN201810924794A CN108739813B CN 108739813 B CN108739813 B CN 108739813B CN 201810924794 A CN201810924794 A CN 201810924794A CN 108739813 B CN108739813 B CN 108739813B
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- pefurazoate
- tetrachlorophthalide
- rice
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/12—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings condensed with a carbocyclic ring
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a bactericidal composition containing tetrachlorophthalide and pefurazoate and application thereof, wherein the active ingredients comprise the tetrachlorophthalide and the pefurazoate, and the weight ratio of the tetrachlorophthalide to the pefurazoate is 1: 40-40:1. The composition has obvious synergistic effect and can be used for preventing and treating rice blast.
Description
Technical Field
The invention belongs to the field of pesticides, and particularly relates to a bactericidal composition containing tetrachlorophthalide and pefurazoate and application thereof.
Background
The rice blast is a rice fungal disease caused by rice blast germs, is a worldwide rice crop disease, the global rice yield loss caused by the rice blast is 11-30% every year, and the rice blast germs mainly overwinter on diseased rice or diseased rice by conidia and hypha. The rice blast is generated at each stage and each part of the rice, the rice blast is most easily infected from the four-leaf stage to the tillering stage and the heading stage, and the leaf blast and the heading blast are most common and the damage is the greatest.
The tetrachlorophthalide is a protective bactericide. Is mainly used for preventing and treating rice blast and rice bacterial leaf blight. Can effectively inhibit the formation of attachment cells on the surface of the rice plant, prevent hypha invasion and have good prevention effect, but can inhibit the re-infection of pathogenic bacteria in the rice plant body. The pyricularia grisea belongs to a low-toxicity bactericide, has good bactericidal and disease-preventing effects, particularly has good preventive effects on rice blast and bakanae disease of rice, can promote seed germination and seedling emergence, promotes seedling growth, and has good permeability on rice seeds.
The single bactericide can not completely and effectively control the generation of germs after being singly used for a long time, and is easy to cause the generation of drug resistance of germs, so that the application amount of the drug is increased, the environment pollution is caused, the compounding between the bactericides can solve the problems of large toxicity and poor effect of the single pesticide, the investment is small, the research and development period is short, the interactive use of different pesticides can delay the generation of the drug resistance of the active ingredient, and the use effect is ideal, so the compounding of the pesticides with different action mechanisms is a research hotspot in the field of the pesticides at present. No report related to the compounding of the tetrachlorophthalide and the pefurazoate exists in the prior art.
Disclosure of Invention
The invention aims to provide the bactericidal composition which has reasonable components, low medication cost and difficult generation of drug resistance, has better control effect on rice blast, and has positive effects on aspects of slowing down the resistance of pathogenic bacteria, reducing the dosage of drugs and the like.
The present invention provides the following technical solutions
A bactericidal composition containing phthalide and pefurazoate consists of the phthalide and the pefurazoate, wherein the weight ratio of the phthalide to the pefurazoate is 1: 40-40:1.
The preferred weight ratio of the tetrachlorophthalide to the pefurazoate in the bactericidal composition is 1:30-10: 1.
The bactericidal composition can be prepared into a preparation acceptable for pesticides, and the total weight of the tetrachlorophthalide and the pefurazoate in the preparation accounts for 1-85% of the total mass of the preparation.
The preferred total weight of the tetrachlorophthalide and pefurazoate in the bactericidal composition accounts for 15-65% of the total mass of the preparation.
The dosage form of the bactericidal composition provided by the invention is suspoemulsion, missible oil, suspending agent, water dispersible granules, oil suspending agent, aqueous emulsion, wettable powder, microemulsion, microcapsule suspending agent and the like. Preferably suspoemulsion, water dispersible granules and wettable powder.
The preparations according to the invention can be prepared in a known manner by mixing the active compounds with customary auxiliaries. The auxiliary materials are selected from one or more of emulsifier, dispersant, wetting agent, disintegrant, binder, antifreeze agent, defoamer, thickener, filler, solvent and the like.
The dispersing agent is selected from one or more of polycarboxylate, lignosulfonate, alkylphenol polyoxyethylene pyrimidine formaldehyde condensate sulfate, alkylbenzene sulfonic acid calcium salt, naphthalene sulfonic acid formaldehyde condensate sodium salt, alkylphenol polyoxyethylene pyrimidine, fatty amine polyoxyethylene pyrimidine, fatty acid polyoxyethylene ester and ester polyoxyethylene pyrimidine.
The humectant is selected from: one or more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, nekal BX, wetting penetrant F, fructus Gleditsiae Abnormalis powder, faeces Bombycis, and fructus Sapindi Mukouossi powder.
The disintegrant is selected from: one or more of bentonite, urea, ammonium sulfate and aluminum chloride.
The binder is selected from: one or more of acacia, white dextrin, methyl cellulose, sodium acrylate, polyvinylpyrrolidone, crosslinked polyvinylpyrrolidone, polyethylene glycol, and polyvinyl alcohol.
The antifreeze agent is selected from: one or more of ethylene glycol, propylene glycol, glycerol and polyethylene glycol.
The defoaming agent is selected from: silicone oil, silicone compound, C10-20 saturated fatty acid compound, and C8-10 fatty alcohol compound.
The thickening agent is selected from: one or more of xanthan gum, polyvinyl alcohol and polyethylene glycol.
The filler is selected from: one or more of kaolin, diatomite, bentonite, attapulgite, white carbon black, starch and light calcium carbonate.
The bactericidal composition is used for preventing and removing rice blast.
The invention has the following beneficial technical effects:
the composition combines two active ingredients with different action mechanisms for use, and can effectively reduce the generation of drug resistance of pathogenic bacteria; the bactericidal composition has obvious synergistic effect, can effectively reduce the application dosage of active ingredients, and reduces environmental pollution.
Detailed Description
The following detailed description of specific embodiments of the present invention is provided in conjunction with examples, but it should be understood that the scope of the present invention is not limited to the specific embodiments.
Example 1: and (3) measuring indoor toxicity of the tetrachlorophthalide and the pefurazoate to the rice blast germs.
The test method comprises the following steps: and (4) potting method. The test refers to the indoor bioassay test criteria for pesticides NY/T1156.8-2007. 8-10 seeds are sown in each pot, each concentration is five times, and each treatment totals 5 pots of rice. During the three-leaf stage of rice, the rice is treated with chemical agent and treated with clear water as blank control. After 3 days of treatment with the agent, surface spores of cultured pathogenic bacteria are washed by sterile water, tween 80 is added to prepare a spore concentration of 1 × 106, and the rice leaves are uniformly sprayed and inoculated by a sprayer. After inoculation, rice seedlings are placed in a moisturizing box, a humidifier is connected, black cloth is used for shading for 24 hours, the humidity is kept at 95%, and the test results are investigated after 12 hours/12 hours of illumination/darkness culture for 7 days. The classification standard executes the agricultural industry standard of the people's republic of China, and the classification method comprises the following steps:
level 0: the whole plant is disease-free;
level 1: brown spot disease is appeared;
and 3, level: typical fusiform disease spots appear, and the area of the disease spots accounts for less than 5 percent of the whole leaf;
and 5, stage: typical scabs, the area of the scab accounts for 6 to 25 percent of the whole leaf;
and 7, stage: typical scabs, the area of the scab accounts for 26% -30% of the whole leaf;
and 9, stage: typical lesion spots, the area of the lesion spots accounts for more than 50% of the whole leaf.
Calculating the prevention and treatment effect by using the disease index, performing statistical analysis by using DPS data processing software, calculating the EC50 of each medicament, and then calculating the cotoxicity coefficient (CTC) according to the Sun Yunpei method.
When the CTC is less than or equal to 80, the composition shows antagonism, when the CTC is more than 80 and less than 120, the composition shows additive action, and when the CTC is more than or equal to 120, the composition shows synergistic action.
Measured virulence index (ATI) ═ standard agent EC 50/test agent EC50 x 100
Theoretical virulence index (TTI) ═ A agent virulence index x percent of A in the mixture + B agent virulence index x percent of B in the mixture
Co-toxicity coefficient (CTC) × 100 [ measured toxicity index (ATI) of the mixture)/Theoretical Toxicity Index (TTI) of the mixture ].
TABLE 1 indoor toxicity assay of Tetrachlorophthalide and Pyricularia oryzae
As can be seen from the above table, the combined use of the phthalide and pefurazoate can improve the control effect on the rice blast, and the ratio of the phthalide to the pefurazoate is 1: within the range of 40-40:1, the composition has a synergistic effect, can effectively reduce the application dosage of active ingredients, and reduces environmental pollution. Particularly preferably, the ratio of the tetrachlorophthalide to the pefurazoate is 1:30-10: 1.
Example 2 field control of the formulation of Tetrachlorophthalide and Pyricularia grisea esters against Pyricularia grisea
The test method comprises the following steps: the method is carried out according to the GB/T17980.19-2000 pesticide field pesticide effect test rule (I) in the method for preventing and controlling the leaf diseases of the rice by using the bactericide.
Test agents:
agent 1: 20% of a suspension of phthalide isoprothiolate (phthalide isoprothiolate: 3: 1);
medicament 2: 40% of water dispersible granules of phthalide isoprothiolate (phthalide isoprothiolate 1: 1);
agent 3: 35% of wettable powder of phthalide isoprothiolate (phthalide isoprothiolate 1: 6);
table 2 field control of the formulation of tetrachlorophthalide and pefurazoate against rice blast
As can be seen from the table above, compared with a single agent, the compound application of the tetrachlorophthalide and the pefurazoate can obviously improve the control effect of the compound on the rice blast, and has obvious synergistic effect. And is safe for crops in field observation.
The above description is only a preferred embodiment of the present invention, and it is obvious to those skilled in the art that modifications may be made without departing from the scope of the present invention, and such modifications are also within the scope of the present invention.
Claims (3)
1. The application of the bactericidal composition containing the tetrachlorophthalide and the pefurazoate for preventing and removing the rice blast is characterized in that: the active ingredients comprise the components of the tetrachlorophthalide and the pefurazoate, and the weight ratio of the tetrachlorophthalide to the pefurazoate is 1:30-10: 1; the total weight percentage of the tetrachlorophthalide and the pefurazoate in the composition is 1-85%.
2. Use according to claim 1, characterized in that: the total weight percentage of the tetrachlorophthalide and the pefurazoate in the composition is 15-65%.
3. Use according to claim 1 or 2, characterized in that: the dosage form of the bactericidal composition is one of water dispersible granules and wettable powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810924794.9A CN108739813B (en) | 2018-08-14 | 2018-08-14 | Bactericidal composition containing tetrachlorophthalide and pefurazoate and application thereof |
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| CN201810924794.9A CN108739813B (en) | 2018-08-14 | 2018-08-14 | Bactericidal composition containing tetrachlorophthalide and pefurazoate and application thereof |
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| CN108739813A CN108739813A (en) | 2018-11-06 |
| CN108739813B true CN108739813B (en) | 2021-01-22 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101697725A (en) * | 2009-10-29 | 2010-04-28 | 深圳诺普信农化股份有限公司 | Pesticide composition containing protective bactericide |
| CN101755755A (en) * | 2009-11-03 | 2010-06-30 | 深圳诺普信农化股份有限公司 | Bactericidal composite taking fluazinam as main ingredient |
| CN103271032A (en) * | 2012-05-31 | 2013-09-04 | 陕西上格之路生物科学有限公司 | Bactericide composition containing SYP-1620 |
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2018
- 2018-08-14 CN CN201810924794.9A patent/CN108739813B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101697725A (en) * | 2009-10-29 | 2010-04-28 | 深圳诺普信农化股份有限公司 | Pesticide composition containing protective bactericide |
| CN101755755A (en) * | 2009-11-03 | 2010-06-30 | 深圳诺普信农化股份有限公司 | Bactericidal composite taking fluazinam as main ingredient |
| CN103271032A (en) * | 2012-05-31 | 2013-09-04 | 陕西上格之路生物科学有限公司 | Bactericide composition containing SYP-1620 |
Non-Patent Citations (1)
| Title |
|---|
| 水稻恶苗病菌对苯并咪唑类及咪唑药物的抗性研究;杨红福等;《安徽农业科学》;20080701;第8151-8152页 * |
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| CN108739813A (en) | 2018-11-06 |
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