CN108849931A - A kind of bactericidal composition and its application containing probenazole and mandipropamid - Google Patents
A kind of bactericidal composition and its application containing probenazole and mandipropamid Download PDFInfo
- Publication number
- CN108849931A CN108849931A CN201810924643.3A CN201810924643A CN108849931A CN 108849931 A CN108849931 A CN 108849931A CN 201810924643 A CN201810924643 A CN 201810924643A CN 108849931 A CN108849931 A CN 108849931A
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- CN
- China
- Prior art keywords
- mandipropamid
- probenazole
- bactericidal composition
- composition
- rice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention provides a kind of bactericidal composition containing probenazole and mandipropamid and its application, active constituent are made of probenazole and mandipropamid, and the weight ratio of the probenazole and mandipropamid is 1:30-30:1.Composition of the invention has significant synergies, and can be used for the prevention and treatment of rice blast.
Description
Technical field
The invention belongs to pesticide fields, and in particular to a kind of bactericidal composition containing probenazole and mandipropamid and
It is applied.
Background technique
Rice blast is the rice fungal disease as caused by Pyricularia oryzae, is that a kind of worldwide rice makees disease, the whole world is annual
Because Rice Yield Loss Caused reaches 11%-30% caused by rice blast, Pyricularia oryzae is mainly with conidium and mycelia in sick rice or disease
It is overwintering on paddy.Rice blast has generation in each period of rice and each position, and four leaf stage to tillering stage and heading stage are most susceptible
Rice blast is contaminated, most commonly seen with leaf pest and fringe pest, harm is maximum.
Probenazole is isothiazole class fungicide, can be used for preventing and treating rice blast and bacterial blight of rice.To rice blast spore
Son is formed with certain inhibiting effect, stronger to spore rudiment inhibiting effect, can inhibit spore intrusion, but do not have to mycelia growth
Inhibiting effect can be absorbed by rice root, and infiltration conduction, can also foliar spray to plant each section rapidly.Mandipropamid
Amine is acid amide fungicides, and the mechanism of action is to inhibit the biosynthesis of phosphatide, to counting leaf portion caused by egg bacteria and fruit greatly absolutely
Real disease has good preventive effect.To spore activity with higher in the stage of sprouting, and it can inhibit mycelia growth and spore
Son is formed, and can be rapidly absorbed by blade, and rest in leaf surface wax coat, be shielded to blade.
A kind of sterilization single dose is used alone for a long time completely effectively to control the generation of germ, and is also easy to cause disease
The generation of bacterium drug resistance causes medicament administration amount to increase, causes environmental pollution, the compounding between sterilization both can solve pesticide single dose
The problem that toxicity is big, effect is poor, but less investment, R&D cycle are short, and being used interchangeably between different pesticides can delay to make
With the generation of object drug resistance, there is ideal using effect, therefore the compounding of pesticide is current between different role mechanism
The research hotspot of pesticide field.The relevant report that probenazole and mandipropamid do not compound in the prior art.
Summary of the invention
The purpose of the present invention is to provide a kind of component is reasonable, drug cost is low, is not likely to produce the Bactericidal composite of drug resistance
Object has preferable control efficiency to rice blast, has product to slow down germ resistance, reduce drug dosage etc.
Pole effect.
The present invention provides following technical scheme
A kind of bactericidal composition containing probenazole and mandipropamid, by probenazole and mandipropamid group
At the weight ratio of probenazole and mandipropamid is 1:30-30:1.
The weight ratio of bactericidal composition of the present invention, preferred probenazole and mandipropamid is 1:5-15:
1。
Bactericidal composition of the present invention can be prepared into the preparation received on pesticide, probenazole and mandipropamid
Total weight in the formulation accounts for the 10%-85% of the entire quality of the pharmaceutical preparations.
Bactericidal composition of the present invention, the total weight of preferred probenazole and mandipropamid in the formulation account for
The 15%-70% of the entire quality of the pharmaceutical preparations.
The dosage form of bactericidal composition of the present invention is suspoemulsion, missible oil, suspending agent, water dispersible granules, granule, oil
Suspending agent, aqueous emulsion, wettable powder, microemulsion, microcapsule suspending agent etc..Preferably suspoemulsion, water dispersible granules, wettable powder
Agent, microemulsion.
The reactive compound can be mixed preparation with customary adjuvant by known way by the preparation of the invention.Institute
The auxiliary material stated is selected from emulsifier, dispersing agent, wetting agent, disintegrating agent, binder, antifreeze, defoaming agent, thickener, filler, solvent
Deng one of or it is a variety of.
The dispersing agent is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulfuric acid of alkylphenol-polyethenoxy
Salt, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy are phonetic, aliphatic amine polyoxyethylene is phonetic, fatty
Sour polyoxyethylene ester, ester polyoxyethylene are one of phonetic or a variety of.
The wetting agent is selected from：Lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent
F, one of spaonin powder, silkworm excrement, spaonin powder or a variety of.
The disintegrating agent is selected from：One of bentonite, urea, ammonium sulfate, aluminium chloride are a variety of.
The binder is selected from：Arabic gum, white dextrin, methylcellulose, sodium acrylate, polyvinylpyrrolidone,
One of crosslinked polyvinylpyrrolidone, polyethylene glycol, polyvinyl alcohol are a variety of.
The antifreeze is selected from：One of ethylene glycol, propylene glycol, glycerine, polyethylene glycol are a variety of.
The defoaming agent is selected from：Silicone oil, silicone compound, C10-20 saturated fat acid compounds, C8-10 fat
One of alcohol compound is a variety of.
The thickener is selected from：One of xanthan gum, polyvinyl alcohol, polyethylene glycol are a variety of.
The filler is selected from：Kaolin, diatomite, bentonite, attapulgite, white carbon black, starch, in precipitated calcium carbonate
It is one or more.
Bactericidal composition of the present invention is used to prevent and kill off the purposes of rice blast.
The present invention obtains following advantageous effects：
Composition of the present invention uses the active ingredient combinations of two kinds of different role mechanism, can effectively reduce germ
The generation of drug resistance；Bactericidal composition of the present invention has significant synergies, and can effectively reduce active constituent
Administration dosage reduces environmental pollution.
Specific embodiment
Below with reference to embodiment, specific embodiments of the present invention will be described in detail, it is to be understood that guarantor of the invention
Shield range is not limited by the specific implementation.
Embodiment 1：The indoor toxicity test of probenazole and mandipropamid to Pyricularia oryzae.
Test method：Pot-culture method.Test reference《Farm-chemical indoor determination test rule NY/T1156.8-2007》.Often
Basin sows rice 8-10 seed, and five repetitions of each concentration are each to handle total 5 basin rice.When rice tri-leaf period, medicine is carried out
Agent processing, is handled with clear water and makees blank control.After chemicals treatment 3 days, by cultured pathogen, with sterile washing lower surface spore
Son is added Tween 80, is made into 1 × 106 spore concentration, and with sprayer, uniformly sprinkling is inoculated on rice leaf.By water after inoculation
Rice seedling is placed in humidistat, accesses humidifier, for 24 hours with black cloth shading, keeps 95% humidity, 12h/12h illumination/dark culturing 7
Experimental investigation result after it.Grade scale executes People's Republic of China's agricultural industry criteria, and stage division is：
0 grade：Whole strain is disease-free；
1 grade：There is brown scab；
3 grades：There is typical spindle scab, lesion area accounts for 5% or less completeblade；
5 grades：Typical scab, lesion area account for the 6%-25% of completeblade；
7 grades：Typical scab, lesion area account for the 26%-30% of completeblade；
9 grades：Typical scab, lesion area account for 50% of completeblade or more.
Control efficiency is calculated with disease index, it is for statistical analysis with DPS data processing software, calculate each medicament
Then EC50 calculates co-toxicity coefficient (CTC) by Sun Yunpei's Method.
When CTC≤80, then composition shows as antagonism, and as 80 < CTC < 120, then composition shows as being added and make
With when CTC >=120, then composition shows as synergistic effect.
Survey toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) × 100
Percentage composition+B the medicament toxicity index of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed
The percentage composition of B in agent
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100.
The indoor toxicity test of 1 probenazole of table and mandipropamid to Pyricularia oryzae
As seen from the above table, the control efficiency that can be improved to rice blast, alkene is applied in combination in probenazole and mandipropamid
Propyl benzene thiazole and mandipropamid proportion are 1:30-30:In 1 range, composition shows as synergistic function, can effectively drop
The administration dosage of low activity ingredient, reduces environmental pollution.Particularly preferred probenazole and mandipropamid proportion are 1:5-15:
1。
2 probenazole of embodiment and mandipropamid compound the field efficacy to rice blast
Test method：Referring to GB/T 17980.19-2000 pesticide field efficacy medicine test criterion (one) bactericidal agent for preventing and treating rice
Method carries out in leaf diseases.
Test medicine：
Medicament 1：28% probenazole mandipropamid suspending agent (probenazole：Mandipropamid=1:1)；
Medicament 2：36% probenazole mandipropamid microemulsion (probenazole：Mandipropamid=5:1)；
Medicament 3：44% probenazole mandipropamid water dispersible granules (probenazole：Mandipropamid=1:
10)；
Medicament 4：60% probenazole mandipropamid wettable powder (probenazole：Mandipropamid=1:
5)；
2 probenazole of table and mandipropamid compound the field efficacy to rice blast
As seen from the above table, compared with single dose, can to significantly improve its right for probenazole and the application of mandipropamid compounding
The control efficiency of rice blast, has significant synergies.And field observation is to crop safety.
The above is only a preferred embodiment of the present invention, to those skilled in the art, this hair is not being departed from
It under the premise of bright raw material, can be suitably modified, these are improved also within protection scope of the present invention.
Claims (6)
1. a kind of bactericidal composition containing probenazole and mandipropamid, it is characterised in that：Active constituent is by phenyl allyloxy thiophene
The weight ratio of azoles and mandipropamid composition, the probenazole and mandipropamid is 1:30-30:1.
2. bactericidal composition according to claim 1, it is characterised in that：The weight of the probenazole and mandipropamid
Amount ratio is 1:5-15:1.
3. bactericidal composition according to claim 1 to 2, it is characterised in that：The probenazole and mandipropamid exist
Total weight percentage composition in composition is 10-85%.
4. bactericidal composition according to claim 3, it is characterised in that：The probenazole and mandipropamid are in group
Closing the total weight percentage composition in object is 15-70%.
5. bactericidal composition described in -4 according to claim 1, it is characterised in that：The bactericidal composition dosage form be suspoemulsion,
One of water dispersible granules, wettable powder, microemulsion etc..
6. bactericidal composition described in -5 is used to prevent and kill off the purposes of rice blast according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810924643.3A CN108849931A (en) | 2018-08-14 | 2018-08-14 | A kind of bactericidal composition and its application containing probenazole and mandipropamid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810924643.3A CN108849931A (en) | 2018-08-14 | 2018-08-14 | A kind of bactericidal composition and its application containing probenazole and mandipropamid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108849931A true CN108849931A (en) | 2018-11-23 |
Family
ID=64318145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810924643.3A Withdrawn CN108849931A (en) | 2018-08-14 | 2018-08-14 | A kind of bactericidal composition and its application containing probenazole and mandipropamid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108849931A (en) |
-
2018
- 2018-08-14 CN CN201810924643.3A patent/CN108849931A/en not_active Withdrawn
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Application publication date: 20181123 |
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