CN108721341A - A kind of Cordyceps militaris Ultramicro-powder and its processing method - Google Patents
A kind of Cordyceps militaris Ultramicro-powder and its processing method Download PDFInfo
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Abstract
The present invention discloses a kind of Cordyceps militaris Ultramicro-powder, refers to the grain size of 90% Cordyceps militaris powder more than 1000 mesh；Processing method includes：1) it takes water content in the Cordyceps militaris of 3%-5%, the coarse powder of 80-120 mesh is ground into Universalpulverizer；2) it is crushed again with omnipotent micronizer, charging rate is 30-50 kgs/hour, and crushing wind speed is 20-30 meter per seconds, obtains 200-300 mesh Cordyceps militaris fine powders；3) continue, with 30-50 kgs/hour of charging rate, to be added in air-stream type ultrafine pulverizer and crush, obtain the superfine powder that granularity is 400-500 mesh；4) it is finally placed in vibration-type micronizer, feeding quantity is crush kettle volume 2/3 to 3/4, and continuous vibration 2.5-3 hours obtains Cordyceps militaris Ultramicro-powder.The Cordyceps militaris Ultramicro-powder of the present invention, the dissolution of wherein active material is more, and bioactivity is strong, has very strong inoxidizability；The Cordyceps militaris Ultramicro-powder mouthfeel obtained is dense, fine and smooth.
Description
Technical field
The present invention relates to a kind of Cordyceps militaris Ultramicro-powder and its processing methods, belong to Cordyceps militaris processing technique field.
Background technology
Active ingredient in Chinese medicine is the material base of its pharmacodynamics effect.Since the active constituent of botanical is usual
Be present in into the cell in cytoplasm, and based on intracellular.In such intact cells, active ingredient dissolution needs
Through multi-layer cellular wall and cell membrane, thus by living organism absorb slowly, utilization rate it is low, have little time sometimes or even also release just
It is excreted, causes the waste of drug, therefore, if cell can be smashed, eliminate intact cell wall and cell membrane to effective
The release of ingredient is formed by this resistance, and wherein active ingredient is made to be in direct contact solvent and dissolve out, and certainly will improve its biology profit
Expenditure enhances its pharmacodynamics effect.Meanwhile the pharmacodynamics effect of Chinese medicine is also closely related with its physical state, changes medicament powder
Size can effectively change its physical state.When the grain size of medicament powder is reduced to micron order, the physical state of the drug will
Apparent variation occurs, is mainly manifested in skin effect enhancing, surface energy is consequently increased, and it is very high that this just assigns medicament powder
Chemism, pharmaceutical activity and drug effect also just enhance therewith.
Ultramicro grinding generally refers to material particles being crushed to the process that diameter is less than 13 microns, the Chinese medicine through ultramicro grinding
Particle has 90% grain size≤13 micron, and Chinese medicine cell-wall breaking ratio is improved up to 90% or more under the grain size.Grain size is in this range
Chinese traditional powder contained by bioactive ingredients will not be destroyed, so the pharmacodynamics of the drug, pharmacological mechanism will not be changed
Become, to that will not constitute a threat in terms of drug safety.Since particle develops to miniaturization, cause material table area and porosity big
The increase of amplitude, thus ultrafine powder have unique physics and chemical property, as good dissolubility, dispersibility, adsorptivity,
Chemism etc..
The current patent in relation to ultramicro grinding has very much, such as has a kind of Chinese patent " air-flow superfine communication technique preparation
The method of lotus nut Ultramicro-powder " (application No. is 201310615488.4) is disclosed using repeatedly dry repeatedly addition anticaking agent, knot
Air-flow crushing is closed, lotus nut Ultramicro-powder is prepared.
Chinese patent " one kind be used as medicine animal body superfine grinding method " (application No. is 201210318193.6), the Ultramicro-powder
Broken method by the processing such as animal body liquid nitrogen flash freezer, ultramicro grinding, freeze-drying of being used as medicine, save to greatest extent be used as medicine it is dynamic
The active ingredient of object makes to be used as medicine and imitates composition contained in animal body patient is allowed to fully absorb, the pharmacological property for the animal body that enables to be used as medicine
It is not fully exerted.
In above-mentioned patent, the concrete technology of ultramicro grinding is not introduced, without statistics indicate that granularity after ultramicro grinding yet
Size.
Separately have, Chinese patent " a kind of technique that ultramicro grinding method prepares Antiphlogistic Powder of Schizonepetae and Ledebouriellae " (application No. is
201710221650.2), which chooses 12 taste bulk pharmaceutical chemicals schizonepeta, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, radix bupleuri, the root of purple-flowered peucedanum, Fructus Aurantii, Fu
Siberian cocklebur, campanulaceae, Rhizoma Chuanxiong, Radix Glycyrrhizae, peppermint are cleaned, dry, is dry respectively, and precomminution then is carried out at the corase meal of grain size 60-120 mesh
Ultramicro grinding is ground into the micropowders of grain size 600-800 mesh, after mixing, is aseptically dispensed, outer packing
Obtain Antiphlogistic Powder of Schizonepetae and Ledebouriellae.
Chinese patent " a kind of ultramicro grinding wall-breaking method of haematococcus pluvialis cell " (application No. is
201310082946.2), it uses Ultra-Micro Grinding Equipment, while being matched with liquid nitrogen plant, keeps haematococcus pluvialis instantaneously cold
Jelly becomes fragile, and improves sporoderm-broken rate, and realizes low temperature and the environmental protection of oxygen is isolated.
In above-mentioned patent document, 1000 mesh are largely not achieved in the granularity of crushing, do not reach the degree of energy smudge cells also,
Even if very low if having clasmatosis percentage of damage.
Further more, Chinese patent " a kind of superfine grinding method of polygonatum " (application No. is 201010171705.1), the method are
Freezing sealwort particle and this two procedures of addition synergist are increased in the fine technical process of sealwort particle.
Chinese patent " preparation method and products thereof of freeze-drying superfine notoginseng powder " (application No. is 201810123038.6), packet
Include step：Radix Notoginseng will be lyophilized under cryogenic, be crushed using micronizer, and obtain freeze-drying superfine notoginseng powder；Wherein,
Cryogenic conditions are that temperature is less than 0 DEG C, are lyophilized in superfine notoginseng powder, and the grain size for the particle that quality accounting is 95% or more is less than 1000
Mesh；Radix Notoginseng is lyophilized is less than 5% containing water quality, and the time of crushing is 2~10min.
Patent " preparation process of Chinese angelica ultrafine powder granule decoction piece " (CN201310040570.9), includes the following steps：S1：
Net system is processed；S2：Slice thickness is 0.3~0.5cm；S3：It is dry：Sheet Radix Angelicae Sinensis is put into drying machine and is dried to moisture
It is 3%~8%；S4：Cool down ultramicro grinding：Sheet Radix Angelicae Sinensis is put into micronizer and carries out ultramicro grinding, ultramicro grinding
Temperature is -50~-20 DEG C, and fineness of powder is 100~1000 mesh；S5：Granulation：Uniform Chinese Angelica Root addition will be pre-mixed to account for always
Softwood is made in the drinking water of weight 25%~80%, and is put into granulator and pelletizes, granular size be 12~24 mesh, 60~90 DEG C
It is dry；S6：It is total mixed；S7：Exterior and interior packing.
Patent " a kind of preparation method of broken wall cordyceps sinensis ultra micro mixed powder " (CN201510610989.2), operating procedure is such as
Under：(1) raw material selects, (2) cleaning, removal of impurities, and (3) shear broken wall, (4) enzymolysis, filtering, (5) concentration/drying, (6) Ultramicro-powder
It is broken, it is final to obtain the above broken wall cordyceps sinensis Ultramicro-powder of 1000 mesh.
In above-mentioned patent document, although powder size reaches 1000 mesh, but lack experimental data to support the knot of gained
By.
Comprehensive existing associated documents, be there are the reason of above problem and disadvantage because ultramicro grinding granule size by
The restriction of several factors such as the type selecting of Ultra-Micro Grinding Equipment and collocation, raw material type, feed moisture content, crushes series, charging
Speed crushes temperature, the time etc. of crushing.Therefore, there is presently no effective ultramicro grinding techniques.
Invention content
In view of the above existing problems in the prior art, the present invention provides a kind of Cordyceps militaris Ultramicro-powder and its processing methods, have
Effect prepares grain size up to Ultramicro-powders more than 1000 mesh.
To achieve the goals above, a kind of Cordyceps militaris Ultramicro-powder that the present invention uses, the Cordyceps militaris Ultramicro-powder refer to
The grain size of 90% Cordyceps militaris powder is more than 1000 mesh.
In addition, the present invention also provides a kind of processing method of Cordyceps militaris Ultramicro-powder, with water content 3%-5% pupa worm
Grass is raw material, by multi-stage crushing, obtains 90% Cordyceps militaris diameter of particle more than 1000 mesh.
As an improvement, being crushed using at least level Four.
As an improvement, the processing method of the Cordyceps militaris Ultramicro-powder includes the following steps：
1) it takes water content in the Cordyceps militaris of 3%-5%, the coarse powder of 80-120 mesh is ground into Universalpulverizer；
2) it by the coarse powder of 80-120 mesh, is crushed with omnipotent micronizer, charging rate is 30-50 kgs/hour, is crushed
Wind speed is 20-30 meter per seconds, obtains 200-300 mesh Cordyceps militaris fine powders；
3) it is broken to be added to air blast ultramicro powder with 30-50 kgs/hour of charging rate for 200-300 mesh Cordyceps militaris fine powders
It is crushed in machine, obtains the superfine powder that grain size is 400-500 mesh；
4) superfine powder of 400-500 mesh is placed in vibration-type micronizer, feeding quantity be crush kettle volume 2/3 to
3/4, continuous vibration 2.5-3 hours obtains Cordyceps militaris Ultramicro-powder.
Compared with prior art, the beneficial effects of the invention are as follows：
1) present invention according to existing pulverizer the characteristics of, use first grinding, air-flow superfine communication technique acquisition grain size for
The superfine powder of 400-500 mesh recycles vibration-type micronizer, makes material in abrading cylinder by higher than excited frequency tens
Impact again, shearing, extruding, abrasive action, constantly refinement decompose, and finally obtain micron order or nano-scale particle.The present invention adds
Have in the Cordyceps militaris Ultramicro-powder of work the grain size of 90% powder up to 1000 mesh more than.
2) in addition, in the Ultramicro-powder that the present invention processes, since grain size is thinner, the dissolution of wherein active material is more, biology
Activity is stronger, and after shaking ultramicro grinding, the stripping quantity of cordyceps sinensis total starches and cordycepin dramatically increases, and the Ultramicro-powder of acquisition resists
Oxidisability is also remarkably reinforced.
3) the Cordyceps militaris Ultramicro-powder mouthfeel that the present invention is obtained is dense, fine and smooth, this is particularly heavy to the exploitation of Cordyceps militaris product
It wants.
Description of the drawings
Fig. 1 is influence of the different concussion ultramicro grinding times to Cordyceps militaris grain size in the present invention；
Fig. 2 is influence of the different concussion ultramicro grinding times to polysaccharide in Cordyceps militaris and cordycepin stripping quantity in the present invention；
Fig. 3 is the Cordyceps militaris powder obtained the different concussion ultramicro grinding times, influence of the leaching liquor to DPPH clearance rates；
Fig. 4 is the Cordyceps militaris powder obtained the different concussion ultramicro grinding times, influence of the leaching liquor to total economic value.
Specific implementation mode
In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention is carried out below further detailed
It describes in detail bright.However, it should be understood that the specific embodiments described herein are merely illustrative of the present invention, it is not limited to this hair
Bright range.
Unless otherwise defined, all technical terms and scientific terms used herein are led with the technology for belonging to the present invention
The normally understood meaning of technical staff in domain is identical, and used term is intended merely to retouch in the description of the invention herein
State the purpose of specific embodiment, it is not intended that in the limitation present invention.
Embodiment 1
A kind of processing method of Cordyceps militaris Ultramicro-powder, includes the following steps：
1) it takes water content in the Cordyceps militaris of 3%-5%, the coarse powder of 80-120 mesh is ground into Universalpulverizer；
2) it by the coarse powder of 80-120 mesh, is crushed with omnipotent micronizer, charging rate is 30 kgs/hour, crushes wind
Speed is 20 meter per seconds, obtains 200-300 mesh Cordyceps militaris fine powders；
3) 200-300 mesh Cordyceps militaris fine powders are added to air-stream type ultrafine pulverizer with 30 kgs/hour of charging rate
Middle crushing obtains the superfine powder that grain size is 400-500 mesh；
4) superfine powder of 400-500 mesh being placed in vibration-type micronizer, feeding quantity is crush kettle volume 2/3,
Continuous vibration 2.5 obtains Cordyceps militaris Ultramicro-powder, wherein 90% Cordyceps militaris diameter of particle is more than 1000 mesh.
Embodiment 2
A kind of processing method of Cordyceps militaris Ultramicro-powder, includes the following steps：
1) it takes water content in the Cordyceps militaris of 3%-5%, the coarse powder of 80-120 mesh is ground into Universalpulverizer；
2) it by the coarse powder of 80-120 mesh, is crushed with omnipotent micronizer, charging rate is 50 kgs/hour, crushes wind
Speed is 30 meter per seconds, obtains 200-300 mesh Cordyceps militaris fine powders；
3) 200-300 mesh Cordyceps militaris fine powders are added to air-stream type ultrafine pulverizer with 50 kgs/hour of charging rate
Middle crushing obtains the superfine powder that grain size is 400-500 mesh；
4) superfine powder of 400-500 mesh being placed in vibration-type micronizer, feeding quantity is crush kettle volume 3/4,
Continuous vibration 3 hours obtains Cordyceps militaris Ultramicro-powder, wherein 90% Cordyceps militaris diameter of particle is more than 1000 mesh.
Embodiment 3
A kind of processing method of Cordyceps militaris Ultramicro-powder, includes the following steps：
1) it takes water content in the Cordyceps militaris of 3%-5%, the coarse powder of 80-120 mesh is ground into Universalpulverizer；
2) it by the coarse powder of 80-120 mesh, is crushed with omnipotent micronizer, charging rate is 30 kgs/hour, crushes wind
Speed is 30 meter per seconds, obtains 200-300 mesh Cordyceps militaris fine powders；
3) 200-300 mesh Cordyceps militaris fine powders are added to air-stream type ultrafine pulverizer with 40 kgs/hour of charging rate
Middle crushing obtains the superfine powder that grain size is 400-500 mesh；
4) superfine powder of 400-500 mesh being placed in vibration-type micronizer, feeding quantity is crush kettle volume 2/3,
Continuous vibration 2.5 hours obtains Cordyceps militaris Ultramicro-powder, wherein 90% Cordyceps militaris diameter of particle is more than 1000 mesh.
Wherein, in step 4), using different grinding times, to (the measurement of grain size, using laser of Cordyceps militaris grain size
Grain-distribution detection instrument, model JL-1166, Jingxin Power Testing Apparatus Co., Ltd., Chengdu) there is following influence：It crushes in 1-
Between 2 hours, grain size reduced slowly, but when being crushed to 2-2.5 hours, the grain size of cordyceps sinensis particle is reduced rapidly, at 2.5 hours
Later, particle size is held essentially constant.Specific variation tendency is as shown in Figure 1.So what the present invention selected is 2.5-3 hours.
Also, with the extension of concussion ultramicro grinding time, the stripping quantity of polysaccharide is in increasing trend in Cordyceps militaris, is being crushed
At 2.5-3 hours, close to the maximum value of polysaccharide stripping quantity, as shown in Figure 2；Equally, with concussion the ultramicro grinding time extension,
The stripping quantity of cordycepin is also in increasing trend in Cordyceps militaris, but growth trend is shallower, after crushing 2.5-3 hours, cordycepin it is molten
Output is also close to maximum value, as shown in Figure 2.
In addition, for the Cordyceps militaris powder that different grinding times obtain, through being impregnated 1 hour in 37 DEG C of water, leaching liquor pair
The clearance rate of DPPH and the influence difference of total economic value are as shown in Figure 3 and Figure 4.
It is being crushed in 1-2 hours ranges it can be seen from Fig. 3, Fig. 4, clearance rate and total antioxygen of the leaching liquor to DPPH
The property changed rises relatively slowly, but when grinding time reaches 2-2.5 hours, leaching liquor is fast to the clearance rate and total economic value of DPPH
Speed rises, when grinding time is more than 2.5 small after, leaching liquor changes the clearance rate effect and total economic value of DPPH unknown
It is aobvious.
The result of this and Fig. 1 are consistent, and illustrate that the grain size of Ultramicro-powder is smaller, the scavenging effect to DPPH and total antioxidation
Property is stronger.It is also indicated that after ultramicro grinding in conjunction with the result of Fig. 2, due to the reduction of diameter of particle, the dissolution of powder active substance
Rate increases, bioactivity enhancing；And it is impregnated 1 hour at 37 DEG C, inoxidizability is stronger, illustrates the polyphenoils released
Matter is more, and bioavilability is higher.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
Any modification, equivalent replacement or improvement etc., should all be included in the protection scope of the present invention made by within refreshing and principle.
Claims (4)
1. a kind of Cordyceps militaris Ultramicro-powder, which is characterized in that the Cordyceps militaris Ultramicro-powder refers to the grain size of 90% Cordyceps militaris powder
More than 1000 mesh.
2. a kind of processing method of Cordyceps militaris Ultramicro-powder, which is characterized in that using water content 3%-5% Cordyceps militaris as raw material,
By multi-stage crushing, 90% Cordyceps militaris diameter of particle is obtained more than 1000 mesh.
3. a kind of processing method of Cordyceps militaris Ultramicro-powder according to claim 2, which is characterized in that using at least level Four powder
It is broken.
4. a kind of processing method of Cordyceps militaris Ultramicro-powder according to claim 2, which is characterized in that include the following steps：
1) it takes water content in the Cordyceps militaris of 3%-5%, the coarse powder of 80-120 mesh is ground into Universalpulverizer；
2) it by the coarse powder of 80-120 mesh, is crushed with omnipotent micronizer, charging rate is 30-50 kgs/hour, crushes wind speed
For 20-30 meter per seconds, 200-300 mesh Cordyceps militaris fine powders are obtained；
3) 200-300 mesh Cordyceps militaris fine powders are added to 30-50 kgs/hour of charging rate in air-stream type ultrafine pulverizer
It crushes, obtains the superfine powder that granularity is 400-500 mesh；
4) superfine powder of 400-500 mesh being placed in vibration-type micronizer, feeding quantity is crush kettle volume 2/3 to 3/4,
Continuous vibration 2.5-3 hours, obtains Cordyceps militaris Ultramicro-powder.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111034800A (en) * | 2020-01-08 | 2020-04-21 | 武汉宜方本草医药科技有限公司 | Preparation method of poria cocos superfine powder solid beverage |
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| CN105030846A (en) * | 2015-09-01 | 2015-11-11 | 合肥工业大学 | Preparation method of cordyceps militaris superfine powder |
| CN105831221A (en) * | 2016-06-22 | 2016-08-10 | 东北林业大学 | Enriched-selenium cordyceps militaris biscuit processing and producing method |
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| CN1544080A (en) * | 2003-11-21 | 2004-11-10 | 钱康南 | Preparation and application of nanometer chrysalid worm grass meal |
| CN102228245A (en) * | 2011-06-24 | 2011-11-02 | 江苏康迪生物科技有限公司 | Granular preparation prepared from ultramicro pure cordycep sporocarp powder and preparation method thereof |
| CN105030846A (en) * | 2015-09-01 | 2015-11-11 | 合肥工业大学 | Preparation method of cordyceps militaris superfine powder |
| CN105831221A (en) * | 2016-06-22 | 2016-08-10 | 东北林业大学 | Enriched-selenium cordyceps militaris biscuit processing and producing method |
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| CN111034800A (en) * | 2020-01-08 | 2020-04-21 | 武汉宜方本草医药科技有限公司 | Preparation method of poria cocos superfine powder solid beverage |
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