CN108713757A - A kind of composition and its preparation method and application improving gastrointestinal tract microenvironment - Google Patents
A kind of composition and its preparation method and application improving gastrointestinal tract microenvironment Download PDFInfo
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- CN108713757A CN108713757A CN201810564385.2A CN201810564385A CN108713757A CN 108713757 A CN108713757 A CN 108713757A CN 201810564385 A CN201810564385 A CN 201810564385A CN 108713757 A CN108713757 A CN 108713757A
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- 239000000203 mixture Substances 0.000 title claims abstract description 74
- 210000001035 gastrointestinal tract Anatomy 0.000 title claims abstract description 70
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000011669 selenium Substances 0.000 claims abstract description 109
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 105
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 105
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 103
- 244000105624 Arachis hypogaea Species 0.000 claims abstract description 61
- 235000020232 peanut Nutrition 0.000 claims abstract description 61
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims abstract description 52
- 244000197580 Poria cocos Species 0.000 claims abstract description 45
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 45
- 150000003742 xyloses Chemical class 0.000 claims abstract description 31
- 235000017060 Arachis glabrata Nutrition 0.000 claims abstract description 28
- 235000010777 Arachis hypogaea Nutrition 0.000 claims abstract description 28
- 235000018262 Arachis monticola Nutrition 0.000 claims abstract description 28
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims abstract description 18
- 235000013305 food Nutrition 0.000 claims abstract description 10
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims abstract description 9
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000003814 drug Substances 0.000 claims abstract description 9
- 238000002386 leaching Methods 0.000 claims description 36
- 239000000243 solution Substances 0.000 claims description 26
- 230000006872 improvement Effects 0.000 claims description 23
- 235000015097 nutrients Nutrition 0.000 claims description 18
- 241000196324 Embryophyta Species 0.000 claims description 17
- 238000000227 grinding Methods 0.000 claims description 14
- 239000000047 product Substances 0.000 claims description 13
- 238000001914 filtration Methods 0.000 claims description 11
- 230000035784 germination Effects 0.000 claims description 11
- 238000007654 immersion Methods 0.000 claims description 10
- 239000012528 membrane Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 230000036541 health Effects 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 238000005507 spraying Methods 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 6
- 229920001542 oligosaccharide Polymers 0.000 claims description 6
- 150000002482 oligosaccharides Chemical class 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 2
- 239000002893 slag Substances 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract description 16
- 230000009286 beneficial effect Effects 0.000 abstract description 10
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- 229940091258 selenium supplement Drugs 0.000 description 88
- 230000000968 intestinal effect Effects 0.000 description 15
- 241000186000 Bifidobacterium Species 0.000 description 12
- 229960003487 xylose Drugs 0.000 description 8
- 238000003809 water extraction Methods 0.000 description 7
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- 238000000605 extraction Methods 0.000 description 5
- 239000013065 commercial product Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
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- 238000001694 spray drying Methods 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
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- 201000006549 dyspepsia Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000007413 intestinal health Effects 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 238000011740 C57BL/6 mouse Methods 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000019926 Keshan disease Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- SRBFZHDQGSBBOR-LECHCGJUSA-N alpha-D-xylose Chemical compound O[C@@H]1CO[C@H](O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-LECHCGJUSA-N 0.000 description 1
- 229940024554 amdinocillin Drugs 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- BWWVAEOLVKTZFQ-ISVUSNJMSA-N chembl530 Chemical compound N(/[C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)=C\N1CCCCCC1 BWWVAEOLVKTZFQ-ISVUSNJMSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229960001471 sodium selenite Drugs 0.000 description 1
- 235000015921 sodium selenite Nutrition 0.000 description 1
- 239000011781 sodium selenite Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 description 1
- CEIZFXOZIQNICU-UHFFFAOYSA-N tenuazonic acid Chemical compound CCC(C)C1NC(=O)C(C(C)=O)=C1O CEIZFXOZIQNICU-UHFFFAOYSA-N 0.000 description 1
- 229920001221 xylan Polymers 0.000 description 1
- 150000004823 xylans Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
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- Alternative & Traditional Medicine (AREA)
- Inorganic Chemistry (AREA)
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Abstract
The present invention provides a kind of compositions and its preparation method and application improving gastrointestinal tract microenvironment, belong to food medicine technical field.The composition for improving gastrointestinal tract microenvironment includes the component of following parts by weight：4.5~5.5 parts of 18~22 parts of the water extract of 90~110 parts of xylo-oligosaccharide, dried orange peel and Poria cocos and water soluble organic selenium；The xylo-oligosaccharide includes two xyloses and three xyloses；The mass percent that two xylose and three xyloses account for the xylo-oligosaccharide is not less than 80%；The peanut sprout that the water soluble organic selenium germinates from selenium-rich peanuts.The composition provided by the invention for improving gastrointestinal tract microenvironment can provide the prebiotics needed for gastrointestinal tract beneficial bacterium, make beneficial bacterium more Adaptable growth environment simultaneously, have the function of adjusting gastrointestinal tract profitable strain proliferation, beneficial bacterium is contributed to increase the decline with harmful bacteria, to safeguard the balance of gastrointestinal bacterial flora.
Description
Technical field
The invention belongs to eat medicine technical field, and in particular to it is a kind of improve gastrointestinal tract microenvironment composition and its preparation side
Method and application.
Background technology
Enteron aisle is the important nutrient absorption of human body and immune organ, and the immunocyte of human body 60%~70% all concentrates on intestines
Road is the main battle ground of our body immunes, and intestinal health has closely related, intestinal flora and human body with intestinal microenvironment
Interdependence and symbiosis, constitute intestinal microecology system, and intestinal microecology participates in organism metabolism, energy balance and immunological regulation
Change Deng, intestinal microecology is related with the generation of a variety of diseases, such as constipation, insomnia, halitosis, and long-term vivotoxin is accumulated very
Cancer threat to life can extremely be caused.Therefore, the intestinal flora of balance, can for keeping intestinal health to have very important meaning
To say the wind vane for being health, by improving intestinal flora situation, there is far reaching significance to health.
Probiotics is microorganism living can play wholesome effect when taking in sufficient amount to host.Existing skill
Have in art artificially improves gastrointestinal tract using Chinese medicine composition, as Chinese patent CN201310285412.X discloses a kind of use
Selenium element compounds to improve the method for gastrointestinal tract microenvironment with low polyxylose alcohol, but selenium source used is sodium selenite, is inorganic selenium,
It is chiefly used in the drug therapy of patient under extreme conditions to use, such as Keshan disease, Kaschin-Beck disease, cancer, toxic side effect is big and inhales
Yield is low, is not suitable for daily health caring and uses.
Invention content
In view of this, the purpose of the present invention is to provide a kind of compositions and preparation method thereof improving gastrointestinal tract microenvironment
And application, the composition can be effectively improved gastrointestinal tract microenvironment and safe to use, good absorbing.
In order to achieve the above-mentioned object of the invention, the present invention provides following technical scheme：
The present invention provides a kind of compositions improving gastrointestinal tract microenvironment, include the component of following parts by weight：Oligomeric wood
4.5~5.5 parts of 18~22 parts of the water extract and water soluble organic selenium of 90~110 parts of sugar, dried orange peel and Poria cocos；
The xylo-oligosaccharide includes two xyloses and three xyloses；Two xylose and three xyloses account for the quality of the xylo-oligosaccharide
Percentage is not less than 80%；
The peanut sprout that the water soluble organic selenium germinates from selenium-rich peanuts.
Preferably, the preparation method of the water extract of the dried orange peel and Poria cocos includes the following steps：
1) dried orange peel, Poria cocos and water are mixed, 1.8~2.2h is extracted at 75~85 DEG C, filtering obtains the first leaching liquor and the
One filter residue；The volume ratio of the gross mass and water of the dried orange peel and Poria cocos is 2Kg:4.5~5.5L；
2) the first filter residue of the step 1) is mixed with water, 1.8~2.2h is extracted at 75~85 DEG C, filtering obtains the
Two leaching liquors and the second filter residue；The quality of first filter residue and the volume ratio of water are 2Kg:4.5~5.5L；
3) merge first leaching liquor and second leaching liquor, obtained mixing leaching liquor is filtered, obtained filter
Liquid is concentrated into 1/4 volume of mixing leaching liquor, obtains the water extract of dried orange peel and Poria cocos.
Preferably, the mass ratio of dried orange peel and Poria cocos is 0.9~1.1 in the step 1):1.
Preferably, the preparation method of the xylo-oligosaccharide includes the following steps：
The xylo-oligosaccharide mixture that glycosidic bond is 2~10 is mixed with water, obtains oligosaccharide mixed solution；The glycosidic bond
It is 1Kg for 2~10 quality of xylo-oligosaccharide mixture and the volume ratio of water：1.9~2.1L；
Aperture is used to divide the oligosaccharide mixed solution under 1.8~2.2MPa pressure for the NF membrane of 1~3nm
From purifying, xylo-oligosaccharide is obtained.
Preferably, the preparation method of the water soluble organic selenium includes the following steps：
I selenium-rich peanuts are mixed with water), 7~9h, the selenium-rich peanuts after being impregnated are impregnated at 55~65 DEG C；
II) by the step I) in immersion after selenium-rich peanuts 4.5~5.5d is grown at 32~37 DEG C, germinateed
Peanut takes peanut sprout as water soluble organic selenium from the germination peanut.
Preferably, the step I) in the Se contents of selenium-rich peanuts be Se content be 5~20mg/kg.
Preferably, the step II) in spray temperature every 3.8~4.2h in growth course be 28~32 DEG C
Plant Selenium-rich nutrient solution；A concentration of 0.1~0.5mg/kg of plasma selenium in the plant Selenium-rich nutrient solution；The plant selenium-rich nutritive
The each amount of spraying of liquid is 100~1000mL/kg.
The present invention provides a kind of preparation methods of the composition of the improvement gastrointestinal tract microenvironment described in above method, including
Following steps：
Water extraction and water soluble organic selenium by xylo-oligosaccharide, dried orange peel and Poria cocos mixture mix, the mixture that will be obtained
Grinding obtains the composition for improving gastrointestinal tract microenvironment.
Preferably, the temperature of mixture is 55~65 DEG C when the grinding, and the time of grinding is 1.8~2.2h.
The present invention provides a kind of composition of improvement gastrointestinal tract microenvironment or by the method preparation of said program
The composition of resulting improvement gastrointestinal tract microenvironment answering in preparing the food, health products or drug that improve gastrointestinal tract microenvironment
With.
The present invention provides a kind of compositions improving gastrointestinal tract microenvironment, include the component of following parts by weight：Oligomeric wood
4.5~5.5 parts of 18~22 parts of the water extract and water soluble organic selenium of 90~110 parts of sugar, dried orange peel and Poria cocos；The xylo-oligosaccharide packet
Include two xyloses and three xyloses；The mass percent that two xylose and three xyloses account for the xylo-oligosaccharide is not less than 80%；It is described
The peanut sprout that water soluble organic selenium germinates from selenium-rich peanuts.The composition provided by the invention for improving gastrointestinal tract microenvironment
Two xyloses and three xyloses can provide the prebiotics needed for gastrointestinal tract beneficial bacterium in middle xylo-oligosaccharide, and beneficial microbe is made to be more easy to adapt to
Intestinal environment contributes to beneficial bacterium to increase the decline with harmful bacteria, to safeguard the balance of gastrointestinal bacterial flora, gastrointestinal tract beneficial bacterium
By preferentially utilizing xylo-oligosaccharide, it is largely proliferated Bifidobacterium, lactic acid bacteria etc., and inhibits harmful bacteria such as clostridium, big
The growth of enterobacteria and salmonella etc., reduces the formation of toxic tunning, so as to improve enteric microorganism environment.It is water-soluble
Organic Selenium can resist inflammation and drug is taken in and injured to caused by flora in gastrointestinal tract, enhance the energy of gastrointestinal tract anti-oxidative damage
Power.First based on the moisture in Poria cocos removal human body taste, then supplemented by the dyspepsia of dried orange peel removal taste and wine product, to reach
The effect that dredging the spleen channel is strengthened the body resistance to consolidate the constitution, while Poria cocos and dried orange peel are the raw material of integration of drinking and medicinal herbs, it can be directly as food consumption.
The result of embodiment：The composition for the improvement gastrointestinal tract microenvironment that the present invention is prepared can obviously increase mouse intestines
The quantity of Bifidobacterium in road, wherein the quantity of Bifidobacterium increases 0.36~0.49lg in low dose group mouse intestinal
CFU/g, the quantity of Bifidobacterium increases 0.82~0.93lg CFU/g, high dose group mouse intestines in middle dose group mouse intestinal
The quantity of Bifidobacterium increases 1.03~1.06lg CFU/g in road.
Further, the application uses selenium-rich peanuts for raw material, and producing high selenium peanut sprout by selenium-rich planting technology is used as
Water soluble organic selenium, Organic Selenium can directly be used from food as food and absorptivity is high.
The water extract and water soluble organic selenium of xylo-oligosaccharide, dried orange peel and Poria cocos are ground by the present invention simultaneously, make each group
Point coupled, so as to get product homogeneity, dispersibility and good water solubility.
Specific implementation mode
The present invention provides a kind of compositions improving gastrointestinal tract microenvironment, include the component of following parts by weight：Oligomeric wood
4.5~5.5 parts of 18~22 parts of the water extract and water soluble organic selenium of 90~110 parts of sugar, dried orange peel and Poria cocos；The xylo-oligosaccharide packet
Include two xyloses and three xyloses；The mass percent that two xylose and three xyloses account for the xylo-oligosaccharide is not less than 80%；It is described
The peanut sprout that water soluble organic selenium germinates from selenium-rich peanuts.
The composition provided by the invention for improving gastrointestinal tract microenvironment includes xylo-oligosaccharide.By weight, described low
Xylan includes 90~110 parts, preferably 95~105 parts, more preferably 100 parts.The xylo-oligosaccharide includes two xyloses and three
Xylose.The mass percent that two xylose and three xyloses account for the xylo-oligosaccharide is not less than 80%, more preferably 85%.
In the present invention, the preparation method of the xylo-oligosaccharide preferably includes following steps：By glycosidic bond be 2~10 it is oligomeric
Wood sugar mixtures are mixed with water, obtain oligosaccharide mixed solution；The quality for the xylo-oligosaccharide mixture that the glycosidic bond is 2~10
Volume ratio with water is 1Kg：1.9~2.1L；Use aperture for the NF membrane of 1~3nm under 1.8~2.2MPa pressure to described
Oligosaccharide mixed solution is isolated and purified, and xylo-oligosaccharide is obtained.In the present invention, the glycosidic bond be 2~10 xylo-oligosaccharide
The quality of mixture and the volume ratio of water are preferably 1Kg：2L.The aperture of the NF membrane is preferably 2nm.The pressure is preferably
2MPa.The total content of the mixture that xylo-oligosaccharide is made of 2~10 monosaccharide, two xyloses and three xyloses is relatively fewer, will be sugared
The xylo-oligosaccharide that glycosidic bond is 2~10 carries out separation using NF membrane can isolate lower two xylose of molecular weight and three xyloses,
The content of two xyloses and three xyloses in xylo-oligosaccharide is improved, two xyloses and three xyloses can provide prebiotic needed for gastrointestinal tract beneficial bacterium
First and suitable growing environment contributes to beneficial bacterium to increase the decline with harmful bacteria, to safeguard the balance of gastrointestinal bacterial flora, stomach
Intestinal beneficial bacterium is largely proliferated Bifidobacterium, lactic acid bacteria etc., and inhibit harmful bacteria such as fusiform bud by preferentially utilizing xylo-oligosaccharide
The growth of spore bacillus, Escherichia coli and salmonella etc. reduces the formation of toxic tunning, so as to improve enteric microorganism ring
Border.
The present invention is not particularly limited the source of the xylo-oligosaccharide raw material, is using this field conventional commercial product
It can.Xylo-oligosaccharide described in the embodiment of the present invention is purchased from the Luohe bio tech ltd Yuan Long.
The present invention is not particularly limited the source of the NF membrane, using this field conventional commercial product.This hair
NF membrane described in bright embodiment is purchased from Nanjing Jiuwu High-tech. Co., Ltd..
The composition provided by the invention for improving gastrointestinal tract microenvironment includes the water extraction of dried orange peel and Poria cocos.By weight
The water extraction of meter, the dried orange peel and Poria cocos includes 18~22 parts, preferably 19~21 parts, more preferably 20 parts.
In the present invention, the preparation method of the water extract of the dried orange peel and Poria cocos preferably includes following steps：
1) dried orange peel, Poria cocos and water are mixed, 1.8~2.2h is extracted at 75~85 DEG C, filtering obtains the first leaching liquor and the
One filter residue；The volume ratio of the gross mass and water of dried orange peel and Poria cocos is 2Kg:4.5~5.5L；
2) the first filter residue of the step 1) is mixed with water, 1.8~2.2h is extracted at 75~85 DEG C, filtering obtains the
Two leaching liquors and the second filter residue；The quality of first filter residue and the volume ratio of water are 2Kg:4.5~5.5L；
3) merge first leaching liquor and second leaching liquor, obtained mixing leaching liquor is filtered, obtained filter
Liquid is concentrated into 1/4 volume of mixing leaching liquor, obtains the water extract of dried orange peel and Poria cocos.
In the present invention, preferably dried orange peel and Poria cocos are mixed with water, 1.8~2.2h is extracted at 75~85 DEG C, filtering obtains the
One leaching liquor and the first filter residue；The volume ratio of the gross mass and water of the dried orange peel and Poria cocos is 2Kg:4.5~5.5L.The extraction
Temperature be preferably 80 DEG C.The time of the extraction is preferably 2h.The mode of the filtering is preferably sieved.The sieving sieve
Aperture be preferably 100~200 mesh, more preferably 150 mesh.The volume ratio of the gross mass and water of the dried orange peel and Poria cocos is preferably
2Kg:5L.The mass ratio of the dried orange peel and Poria cocos is preferably 0.9~1.1:1, more preferably 1：1.
After obtaining the first filter residue, the present invention preferably mixes first filter residue with water, at 75~85 DEG C extract 1.8~
2.2h, filtering, obtains the second leaching liquor and the second filter residue；The quality of first filter residue and the volume ratio of water are 2Kg:4.5~
5.5L.In the present invention, the temperature of the extraction is preferably 80 DEG C.The time of the extraction is preferably 2h.The mode of the filtering
Preferably it is sieved.The aperture of the sieving sieve is preferably 100~200 mesh, more preferably 150 mesh.The matter of first filter residue
Amount and the volume ratio of water are preferably 2Kg:5L.
After obtaining the second leaching liquor, the present invention preferably merges first leaching liquor and second leaching liquor, will obtain
Mixing leaching liquor filtering, obtained filtrate be concentrated into mixing leaching liquor 1/4 volume, obtain the water extract of dried orange peel and Poria cocos.
In the present invention, the mode of the concentration is preferably concentrated under reduced pressure.The pressure of the reduced pressure is preferably 8~10Mpa, more preferably
For 9Mpa.By theory of traditional Chinese medical science " gas general rule all kinds of diseases and ailments are not given birth to ", gastrointestinal disease is that the spleen channel is obstructed, first in Poria cocos removal human body taste
Moisture based on, then with dried orange peel remove taste dyspepsia and wine product supplemented by, to achieve the effect that dredge the spleen channel strengthen the body resistance to consolidate the constitution.
The present invention is not particularly limited the source of the dried orange peel and Poria cocos raw material, is using this field conventional commercial product
It can.
The composition provided by the invention for improving gastrointestinal tract microenvironment includes water soluble organic selenium.By weight, institute
It includes 4.5~5.5 parts to state water soluble organic selenium, preferably 4.8~5.2 parts, more preferably 5 parts.
In the present invention, the preparation method of the water soluble organic selenium preferably includes following steps：
I selenium-rich peanuts are mixed with water), 7~9h, the selenium-rich peanuts after being impregnated are impregnated at 55~65 DEG C；
II) by the step I) in immersion after selenium-rich peanuts 4.5~5.5d is grown at 32~37 DEG C, germinateed
Peanut takes peanut sprout as water soluble organic selenium from the germination peanut.
The present invention preferably mixes selenium-rich peanuts with water, and 7~9h is impregnated at 55~65 DEG C, the selenium-rich flower after being impregnated
It is raw.In the present invention, the temperature of the immersion is preferably 58~62 DEG C, more preferably 60 DEG C.The time of the immersion is preferably 8h.
The Se content of the selenium-rich peanuts is preferably 5~20mg/kg, more preferably 10mg/kg.Selenium-rich is spent when the present invention is to the immersion
The volume ratio of raw quality and water is not particularly limited, and water can submerge selenium-rich peanuts.
After selenium-rich peanuts after being impregnated, the present invention grows the selenium-rich peanuts after the immersion at 32~37 DEG C
4.5~5.5d obtains germination peanut, takes peanut sprout as water soluble organic selenium from the germination peanut.It is described in the present invention
The temperature of growth is preferably 35 DEG C.The time of the growth is preferably 5d.It is preferably sprayed every 3.8~4.2h in growth course
The plant Selenium-rich nutrient solution that temperature is 28~32 DEG C.The interval time of the sprinkling plant Selenium-rich nutrient solution is preferably 4h.
The temperature of the plant Selenium-rich nutrient solution of the sprinkling is preferably 30 DEG C.Plasma selenium concentration is preferably in the plant Selenium-rich nutrient solution
0.1~0.5mg/kg, more preferably 0.3mg/kg.The each amount of spraying of plant Selenium-rich nutrient solution is preferably 100~1000mL/
Kg, more preferably 500mL/kg.It uses selenium-rich peanuts for raw material, high selenium peanut sprout is produced by selenium-rich planting technology, with high selenium
Peanut sprout is as water-soluble Organic Selenium, and Organic Selenium can directly be used from food as food and absorptivity is high.
The present invention is not particularly limited the source of the selenium-rich peanuts raw material and Selenium-rich nutrient solution, using this field routine
Commercial product.Selenium-rich peanuts described in the embodiment of the present invention are purchased from the Tangshan bio tech ltd Xi Pu.The plant
Selenium-rich nutrient solution is purchased from Shanxi Mecillinam pharmaceutcal corporation, Ltd.
The present invention provides a kind of preparation methods of the composition of the improvement gastrointestinal tract microenvironment described in said program, including
Following steps：Xylo-oligosaccharide, the water extract of dried orange peel and Poria cocos mixture and water soluble organic selenium are mixed, the mixture that will be obtained
Grinding obtains the composition for improving gastrointestinal tract microenvironment.
In the present invention, the temperature of mixture is preferably 55~65 DEG C when the grinding, more preferably 60 DEG C.The grinding
Time is preferably 1.8~2.2h, more preferably 2h.The mode of the grinding is preferably homogenized.The rotating speed of the homogenate is preferably
2000~2500r/min, more preferably 2300r/min.Water extraction by xylo-oligosaccharide, dried orange peel and Poria cocos mixture and water solubility
Organic Selenium is ground, and each component is made to be coupled, and can improve product homogeneity, dispersibility and water solubility.The grinding
Equipment is preferably nanometer mill.
In the present invention, after obtained mixture is ground, obtained grinding product is preferably spray-dried by the present invention,
Obtain improving the composition of gastrointestinal tract microenvironment.The temperature of grinding product is preferably 55~65 DEG C when the spray drying, more excellent
It is selected as 60 DEG C.The inlet temperature of the spray drying is preferably 145~155 DEG C, more preferably 150 DEG C.The spray drying
Outlet temperature is preferably 105~115 DEG C, more preferably 110 DEG C.
The present invention provides a kind of composition of improvement gastrointestinal tract microenvironment or by the method preparation of said program
The composition of resulting improvement gastrointestinal tract microenvironment answering in preparing the food, health products or drug that improve gastrointestinal tract microenvironment
With.In the present invention, mass percentage of the composition for improving gastrointestinal tract microenvironment in food is preferably 20~95%,
More preferably 60%.The dose of the food for improving gastrointestinal tract microenvironment is preferably 5~10g/ days, more preferably 8g/ days.
Mass percentage of the composition for improving gastrointestinal tract microenvironment in health products is preferably 20~95%, more preferably
60%.The dose of the health products for improving gastrointestinal tract microenvironment is preferably 5~10g/ days, more preferably 8g/ days.It is described to change
Mass percentage of the composition of kind gastrointestinal tract microenvironment in drug is preferably 20~95%, and more preferably 60%.It is described
The dose for improving the drug of gastrointestinal tract microenvironment is preferably 5~10g/ days, more preferably 8g/ days.
Below in conjunction with the embodiment in the present invention, the technical solution in the present invention is clearly and completely described.It is aobvious
So, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the reality in the present invention
Example is applied, every other embodiment obtained by those of ordinary skill in the art without making creative efforts all belongs to
In the scope of protection of the invention.
Embodiment 1
The xylo-oligosaccharide that 100g glycosidic bonds are 2~10 is mixed with 190mL water, aperture is used to exist for the NF membrane of 1nm
It is isolated and purified to obtain refined solution under 1.8MPa pressure；It is measured using QB/T2984-2008, two in obtained refined solution
The mass percent that xylose and three xyloses account for xylo-oligosaccharide is 86%, the oligomeric wood as the composition for improving gastrointestinal tract microenvironment
Sugar.
110g dried orange peels, 100g Poria cocos are mixed with 470mL water, 2.2h is extracted at 85 DEG C, using 100 mesh screens, is obtained
First leaching liquor and the first filter residue；First filter residue mixes to (quality of the first filter residue and the volume ratio of water are 2Kg with water:
4.5L), 1.8h is extracted at 75 DEG C, using 200 mesh screens, obtains the second leaching liquor and the second filter residue；Merge the first leaching liquor
It is concentrated into 1/4 volume using 100 mesh screens with the second leaching liquor, obtains the water extract of dried orange peel and Poria cocos.
Selenium-rich peanuts are mixed with water, impregnate 9h at 55 DEG C, the selenium-rich peanuts after being impregnated；After obtained immersion
Selenium-rich peanuts grow 4.5d at 37 DEG C, spray the plant selenium-rich that temperature is 28 DEG C every 4.2h in growth course and seek
Nutrient solution (a concentration of 0.1mg/kg of plasma selenium, the amount of spraying are 100mL/kg in plant Selenium-rich nutrient solution), obtains germination peanut, will send out
The peanut sprout of bud peanut is taken as water soluble organic selenium.
Take the water extraction 22g and water soluble organic selenium 4.5g for xylo-oligosaccharide 90g, dried orange peel and the Poria cocos that above-mentioned steps obtain mixed
It closes, 2.2h is ground with the rotating speed of the rotating speed of 2000r/min at 55 DEG C, abrasive material is obtained, the abrasive material is adjusted to temperature
It is spray-dried (inlet temperature is 145 DEG C, and outlet temperature is 115 DEG C) after being 65 DEG C, obtains improving gastrointestinal tract microenvironment
Composition.
Embodiment 2
The xylo-oligosaccharide that 100g glycosidic bonds are 2~10 is mixed with 210mL water, aperture is used to exist for the NF membrane of 3nm
It is isolated and purified to obtain refined solution under 2.2MPa pressure；Two xyloses and three xyloses account for the matter of xylo-oligosaccharide in obtained refined solution
It is 83% to measure percentage, the xylo-oligosaccharide as the composition for improving gastrointestinal tract microenvironment.
90g dried orange peels, 100g Poria cocos are mixed with 520mL water, 1.8h is extracted at 75 DEG C, using 200 mesh screens, obtains
One leaching liquor and the first filter residue；First filter residue mixes to (quality of the first filter residue and the volume ratio of water are 2Kg with water:5.5L),
2.2h is extracted at 85 DEG C, using 100 mesh screens, obtains the second leaching liquor and the second filter residue；Merge the first leaching liquor and second
Leaching liquor is concentrated into 1/4 volume using 100 mesh screens, obtains the water extract of dried orange peel and Poria cocos.
Selenium-rich peanuts are mixed with water, impregnate 7h at 65 DEG C, the selenium-rich peanuts after being impregnated；After obtained immersion
Selenium-rich peanuts grow 5.5d at 32 DEG C, spray the plant selenium-rich that temperature is 32 DEG C every 3.8h in growth course and seek
Nutrient solution (a concentration of 0.5mg/kg of plasma selenium, the amount of spraying are 1000mL/kg in plant Selenium-rich nutrient solution), obtains germination peanut, will
The peanut sprout of germination peanut is taken as water soluble organic selenium.
Take the water extraction 18g and water soluble organic selenium 5.5g for xylo-oligosaccharide 110g, dried orange peel and the Poria cocos that above-mentioned steps obtain
Mixing grinds 1.8h with the rotating speed of the rotating speed of 2500r/min at 65 DEG C, obtains abrasive material, and the abrasive material is adjusted to temperature
Degree is spray-dried (inlet temperature is 155 DEG C, and outlet temperature is 105 DEG C) after being 55 DEG C, obtain improving gastrointestinal tract microenvironment
Composition.
Embodiment 3
The xylo-oligosaccharide that 100g glycosidic bonds are 2~10 is mixed with 200mL water, aperture is used to exist for the NF membrane of 2nm
It is isolated and purified to obtain refined solution under 2.0MPa pressure；Two xyloses and three xyloses account for the matter of xylo-oligosaccharide in obtained refined solution
It is 85% to measure percentage, the xylo-oligosaccharide as the composition for improving gastrointestinal tract microenvironment.
100g dried orange peels, 100g Poria cocos are mixed with 500mL water, 2h is extracted at 80 DEG C, using 150 mesh screens, obtains
One leaching liquor and the first filter residue；First filter residue mixes to (quality of the first filter residue and the volume ratio of water are 2Kg with water:5L), exist
2h is extracted at 80 DEG C, using 150 mesh screens, obtains the second leaching liquor and the second filter residue；Merge the first leaching liquor and the second extraction
Liquid is concentrated into 1/4 volume using 150 mesh screens, obtains the water extract of dried orange peel and Poria cocos mixture.
Selenium-rich peanuts are mixed with water, impregnate 8h at 60 DEG C, the selenium-rich peanuts after being impregnated；After obtained immersion
Selenium-rich peanuts grow 5d at 35 DEG C, spray the plant Selenium-rich nutrient solution that temperature is 30 DEG C every 4h in growth course
(a concentration of 0.3mg/kg of plasma selenium in plant Selenium-rich nutrient solution, the amount of spraying are 500mL/kg), obtains germination peanut, germination is spent
Raw peanut sprout is taken as water soluble organic selenium.
Take the water extraction 20g and water soluble organic selenium 5g for xylo-oligosaccharide 100g, dried orange peel and the Poria cocos that above-mentioned steps obtain mixed
It closes, 2h is ground with the rotating speed of the rotating speed of 2300r/min at 60 DEG C, obtains abrasive material, the abrasive material, which is adjusted to temperature, is
It is spray-dried (inlet temperature is 150 DEG C, and outlet temperature is 110 DEG C) after 60 DEG C, obtains the group for improving gastrointestinal tract microenvironment
Close object.
Reference examples 1
The water extract and water of the xylo-oligosaccharide, dried orange peel and the Poria cocos mixture that are prepared using method described in embodiment 3
Dissolubility Organic Selenium, and mixing and spraying out drying is carried out according to ratio described in embodiment 3, but without grinding, the group that will be obtained
Close object example as a contrast.I.e. in addition to without grinding, other operating procedures are completed identical with embodiment 3.
Embodiment 4
The composition for the improvement gastrointestinal tract microenvironment that Examples 1 to 3 is prepared is as experimental group 1~3, by reference examples
The composition of the 1 gastrointestinal tract microenvironment being prepared as a control group, is dissolved in 80 DEG C of water (the group of gastrointestinal tract microenvironment respectively
The volume ratio of the quality and water of closing object is 1Kg：4L), the appearance and dissolubility of each group are measured, concrete outcome is as shown in table 1.
The appearance and dissolubility of the composition for the improvement gastrointestinal tract microenvironment that the different groups of table 1 are prepared
| Number | Appearance | Dissolubility |
| Control group | Caking, granularity are uneven | Still there is solid to stick chamber wall and bottom under stirring |
| Experimental group | Loosely, epigranular | At once clear transparent solutions are dissolved under stirring |
As can be seen from Table 1, the composition epigranular for the improvement gastrointestinal tract microenvironment that the present invention is prepared, loosely,
Good water solubility.
Embodiment 5
Adjust gastrointestinal bacterial flora function zoopery
The C57BL/6 mouse that 100 weight are 8 weeks in 20~25g age of mouse are chosen, are randomly divided into 10 groups.Feed this respectively
The composition for the improvement gastrointestinal tract microenvironment that inventive embodiments 1~3 are prepared, sets basic, normal, high three dosage in experiment
Group, respectively 0.42g/kg, 0.83g/kg, 1.70g/kg are respectively equivalent to 5,10,20 times of human body recommended amounts (5g), simultaneously
Separately set distilled water control group.30~60min and Bifidobacterium number in mouse intestinal is measured before to sample to 30~90min after sample
Amount, concrete structure are as shown in table 2.
Influence (lgCFU/g X ± SD) of the different group samples of table 2 to animal bifidobacteria
As can be seen from Table 2, the composition for the improvement gastrointestinal tract microenvironment that the present invention is prepared can obviously increase mouse
The quantity of Bifidobacterium in enteron aisle, wherein in low dose group mouse intestinal the quantity of Bifidobacterium increase 0.36~
0.49lgCFU/g, the quantity of Bifidobacterium increases 0.82~0.93lgCFU/g, high dose group in middle dose group mouse intestinal
The quantity of Bifidobacterium increases 1.03~1.06lgCFU/g in mouse intestinal, the results showed that：The improvement that the present invention is prepared
The composition of gastrointestinal tract microenvironment has the function of adjusting gastrointestinal tract profitable strain proliferation.
Embodiment 6
Clinical observation experiment
30 constipation/upset,gastro-intestinal volunteer (age 60~65 years old, male 15, women 15) is randomly choosed to carry out
Clinical observation is taken 2 times, is counted each taking the composition 5g for the improvement gastrointestinal tract microenvironment that the present invention is prepared daily
Symptom improves situation.14 patient symptoms are improved within first day, improvement rate 46.67%；9 patient symptoms obtain within second day
Improve, improvement rate 30%；Third day to the 7th day 6 patient symptoms are improved, improvement rate 20%.Wherein 3 defecations
State becomes paste from scattered paste shape, is obviously improved by abdomen bearing down and is disappeared for abdomen bearing down, and enlightenment this product has two-way tune
Section acts on.Statistics shows that the total effective rate that this product improves gastrointestinal function is 96.67%, and has no bad anti-during taking
It answers.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of composition improving gastrointestinal tract microenvironment, which is characterized in that include the component of following parts by weight：Xylo-oligosaccharide 90
~110 parts, 4.5~5.5 parts of 18~22 parts of the water extract and water soluble organic selenium of dried orange peel and Poria cocos；
The xylo-oligosaccharide includes two xyloses and three xyloses；Two xylose and three xyloses account for the quality percentage of the xylo-oligosaccharide
Than being not less than 80%；
The peanut sprout that the water soluble organic selenium germinates from selenium-rich peanuts.
2. the composition according to claim 1 for improving gastrointestinal tract microenvironment, which is characterized in that the dried orange peel and Poria cocos
The preparation method of water extract includes the following steps：
1) dried orange peel, Poria cocos and water are mixed, 1.8~2.2h is extracted at 75~85 DEG C, filtering obtains the first leaching liquor and the first filter
Slag；The volume ratio of the gross mass and water of the dried orange peel and Poria cocos is 2Kg:4.5~5.5L；
2) the first filter residue of the step 1) is mixed with water, 1.8~2.2h is extracted at 75~85 DEG C, filtering obtains the second leaching
Extract and the second filter residue；The quality of first filter residue and the volume ratio of water are 2Kg:4.5~5.5L；
3) merge first leaching liquor and second leaching liquor, obtained mixing leaching liquor is filtered, obtained filtrate is dense
It is reduced to 1/4 volume of mixing leaching liquor, obtains the water extract of dried orange peel and Poria cocos.
3. the composition according to claim 2 for improving gastrointestinal tract microenvironment, which is characterized in that dried orange peel in the step 1)
Mass ratio with Poria cocos is 0.9~1.1:1.
4. the composition according to claim 1 for improving gastrointestinal tract microenvironment, which is characterized in that the system of the xylo-oligosaccharide
Preparation Method includes the following steps：
The xylo-oligosaccharide mixture that glycosidic bond is 2~10 is mixed with water, obtains oligosaccharide mixed solution；The glycosidic bond is 2
The quality of~10 xylo-oligosaccharide mixture and the volume ratio of water are 1Kg：1.9~2.1L；
Use aperture under 1.8~2.2MPa pressure the oligosaccharide mixed solution detach for the NF membrane of 1~3nm it is pure
Change, obtains xylo-oligosaccharide.
5. the composition of the improvement gastrointestinal tract microenvironment according to Claims 1 to 4 any one, which is characterized in that described
The preparation method of water soluble organic selenium includes the following steps：
I selenium-rich peanuts are mixed with water), 7~9h, the selenium-rich peanuts after being impregnated are impregnated at 55~65 DEG C；
II) by the step I) in immersion after selenium-rich peanuts 4.5~5.5d is grown at 32~37 DEG C, obtain germination flower
It is raw, take peanut sprout as water soluble organic selenium from the germination peanut.
6. it is according to claim 5 improve gastrointestinal tract microenvironment composition, which is characterized in that the step I) in selenium-rich
The Se content of peanut is 5~20mg/kg.
7. it is according to claim 5 improve gastrointestinal tract microenvironment composition, which is characterized in that the step II) in
In growth course the plant Selenium-rich nutrient solution that a temperature is 28~32 DEG C is sprayed every 3.8~4.2h；The plant selenium-rich battalion
A concentration of 0.1~0.5mg/g of plasma selenium in nutrient solution；The each amount of spraying of the plant Selenium-rich nutrient solution is 100~1000mL/
kg。
8. the preparation method of the composition of the improvement gastrointestinal tract microenvironment described in claim 1~7 any one, including walk as follows
Suddenly：
The water extract of xylo-oligosaccharide, dried orange peel and Poria cocos and water soluble organic selenium are mixed, obtained mixture is ground, is changed
The composition of kind gastrointestinal tract microenvironment.
9. preparation method according to claim 8, which is characterized in that the temperature of mixture is 55~65 when the grinding
DEG C, the time of grinding is 1.8~2.2h.
10. described in claim 1~7 any one improvement gastrointestinal tract microenvironment composition or by claim 8 or 9 methods
The composition for the improvement gastrointestinal tract microenvironment being prepared is in preparing the food, health products or drug that improve gastrointestinal tract microenvironment
Application.
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