CN108698997A - 组蛋白脱甲基酶抑制剂 - Google Patents
组蛋白脱甲基酶抑制剂 Download PDFInfo
- Publication number
- CN108698997A CN108698997A CN201680082794.8A CN201680082794A CN108698997A CN 108698997 A CN108698997 A CN 108698997A CN 201680082794 A CN201680082794 A CN 201680082794A CN 108698997 A CN108698997 A CN 108698997A
- Authority
- CN
- China
- Prior art keywords
- compound
- optionally substituted
- formula
- aryl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *C(N)=CC(O)=N Chemical compound *C(N)=CC(O)=N 0.000 description 1
- ACWLEWUJESQONJ-RQOWECAXSA-N C=C(/C=C(/P)\SN)O Chemical compound C=C(/C=C(/P)\SN)O ACWLEWUJESQONJ-RQOWECAXSA-N 0.000 description 1
- WFQDLPYZEDSFGB-IBGZPJMESA-N CC(C)(C)OC(N(CCc1c2)[C@@H](CN(C(c3c4cccc3)=O)C4=O)c1ccc2Br)=O Chemical compound CC(C)(C)OC(N(CCc1c2)[C@@H](CN(C(c3c4cccc3)=O)C4=O)c1ccc2Br)=O WFQDLPYZEDSFGB-IBGZPJMESA-N 0.000 description 1
- WFQDLPYZEDSFGB-LJQANCHMSA-N CC(C)(C)OC(N(CCc1c2)[C@H](CN(C(c3c4cccc3)=O)C4=O)c1ccc2Br)=O Chemical compound CC(C)(C)OC(N(CCc1c2)[C@H](CN(C(c3c4cccc3)=O)C4=O)c1ccc2Br)=O WFQDLPYZEDSFGB-LJQANCHMSA-N 0.000 description 1
- TVHTZUWCTNLNGQ-UHFFFAOYSA-N O=C(c1c2cccc1)N(CC1=NCCc3cc(Br)ccc13)C2=O Chemical compound O=C(c1c2cccc1)N(CC1=NCCc3cc(Br)ccc13)C2=O TVHTZUWCTNLNGQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
- C12Y114/11027—[Histone H3]-lysine-36 demethylase (1.14.11.27)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562271654P | 2015-12-28 | 2015-12-28 | |
| US62/271,654 | 2015-12-28 | ||
| US201662438435P | 2016-12-22 | 2016-12-22 | |
| US62/438,435 | 2016-12-22 | ||
| PCT/US2016/068767 WO2017117154A1 (en) | 2015-12-28 | 2016-12-27 | Histone demethylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108698997A true CN108698997A (zh) | 2018-10-23 |
Family
ID=59086937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680082794.8A Pending CN108698997A (zh) | 2015-12-28 | 2016-12-27 | 组蛋白脱甲基酶抑制剂 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US10059687B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3397617A4 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6883913B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN108698997A (cg-RX-API-DMAC7.html) |
| TW (1) | TW201722930A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017117154A1 (cg-RX-API-DMAC7.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109438339A (zh) * | 2018-12-22 | 2019-03-08 | 山东大学 | Rbp2酶抑制剂小分子化合物wxsa-072a及其制备方法与抗胃癌应用 |
| CN109456262A (zh) * | 2018-12-22 | 2019-03-12 | 山东大学 | 基于抑制组蛋白去甲基化酶化合物及其制备方法与抗胃癌应用 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108698997A (zh) | 2015-12-28 | 2018-10-23 | 赛尔基因昆蒂赛尔研究公司 | 组蛋白脱甲基酶抑制剂 |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| ES2991090T3 (es) | 2017-03-30 | 2024-12-02 | Univ Freiburg Albert Ludwigs | Inhibidores de KDM4 |
| JP2024168540A (ja) | 2023-05-24 | 2024-12-05 | トヨタ自動車株式会社 | 二次電池および電池モジュール |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006070878A1 (ja) * | 2004-12-28 | 2006-07-06 | Astellas Pharma Inc. | カルボン酸誘導体またはその塩 |
| WO2013143597A1 (en) * | 2012-03-29 | 2013-10-03 | Glaxo Group Limited | Demethylase enzymes inhibitors |
| DK2903968T3 (en) * | 2012-10-02 | 2017-01-30 | Gilead Sciences Inc | INHIBITORS OF HISTON DEMETHYLASES |
| LT2934145T (lt) * | 2012-12-19 | 2018-02-26 | Celgene Quanticel Research, Inc. | Histono demetilazės inhibitoriai |
| KR20150100814A (ko) * | 2012-12-21 | 2015-09-02 | 콴티셀 파마슈티컬스, 인크. | 히스톤 데메틸라제 억제제 |
| WO2015200709A1 (en) * | 2014-06-25 | 2015-12-30 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
| CN108698997A (zh) | 2015-12-28 | 2018-10-23 | 赛尔基因昆蒂赛尔研究公司 | 组蛋白脱甲基酶抑制剂 |
-
2016
- 2016-12-27 CN CN201680082794.8A patent/CN108698997A/zh active Pending
- 2016-12-27 EP EP16882525.5A patent/EP3397617A4/en not_active Withdrawn
- 2016-12-27 US US15/391,773 patent/US10059687B2/en active Active
- 2016-12-27 JP JP2018533758A patent/JP6883913B2/ja not_active Expired - Fee Related
- 2016-12-27 WO PCT/US2016/068767 patent/WO2017117154A1/en not_active Ceased
- 2016-12-28 TW TW105143541A patent/TW201722930A/zh unknown
-
2018
- 2018-07-19 US US16/040,402 patent/US10597379B2/en active Active
-
2020
- 2020-01-24 US US16/751,432 patent/US11001568B2/en active Active
-
2021
- 2021-04-12 US US17/227,570 patent/US11731954B2/en active Active
- 2021-05-03 JP JP2021078218A patent/JP2021121599A/ja active Pending
-
2023
- 2023-03-10 JP JP2023037940A patent/JP2023085300A/ja not_active Ceased
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109438339A (zh) * | 2018-12-22 | 2019-03-08 | 山东大学 | Rbp2酶抑制剂小分子化合物wxsa-072a及其制备方法与抗胃癌应用 |
| CN109456262A (zh) * | 2018-12-22 | 2019-03-12 | 山东大学 | 基于抑制组蛋白去甲基化酶化合物及其制备方法与抗胃癌应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3397617A4 (en) | 2019-05-22 |
| TW201722930A (zh) | 2017-07-01 |
| WO2017117154A1 (en) | 2017-07-06 |
| US20210238161A1 (en) | 2021-08-05 |
| US20200157077A1 (en) | 2020-05-21 |
| US11731954B2 (en) | 2023-08-22 |
| US10059687B2 (en) | 2018-08-28 |
| JP2021121599A (ja) | 2021-08-26 |
| US20180319769A1 (en) | 2018-11-08 |
| JP2023085300A (ja) | 2023-06-20 |
| US11001568B2 (en) | 2021-05-11 |
| JP2019500380A (ja) | 2019-01-10 |
| US20170183325A1 (en) | 2017-06-29 |
| JP6883913B2 (ja) | 2021-06-09 |
| EP3397617A1 (en) | 2018-11-07 |
| US10597379B2 (en) | 2020-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181023 |