CN108685733A - A kind of strength degerming bacteriostatic hand sanitizer - Google Patents
A kind of strength degerming bacteriostatic hand sanitizer Download PDFInfo
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- CN108685733A CN108685733A CN201810782756.4A CN201810782756A CN108685733A CN 108685733 A CN108685733 A CN 108685733A CN 201810782756 A CN201810782756 A CN 201810782756A CN 108685733 A CN108685733 A CN 108685733A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The present invention relates to individuals to wash shield product technical field, and in particular to a kind of strength degerming bacteriostatic hand sanitizer.The hand cleanser includes following component:Anion surfactant, nonionic surface active agent, ethyl alcohol, glycerine, disodium hydrogen phosphate-phosphate sodium dihydrogen buffer solution, composite hydrolytic enzyme, strength bacteria remover, pigment, essence and deionized water.Wherein, strength bacteriostatic agent is the substance containing multiple polypeptides class, polysaccharide and alkaloid extracted from several kinds of Chinese medicinal materials;Anion surfactant is fatty alcohol polyoxyethylene ether phosphate monoester, sodium sulfate of polyethenoxy ether of fatty alcohol or neopelex;Nonionic surfactant is lauric monoethanolamide, ethylene glycol stearate or coconut oil di-methylcarbinol amide;Hand cleanser has good decontamination performance of deoiling, and also has good bactericidal anti-inflammatory effects, pro-skin is not hurt hands, very green safe.
Description
Technical field
The present invention relates to individuals to wash shield product technical field, and in particular to a kind of strength degerming bacteriostatic hand sanitizer.
Background technology
Hand cleanser is a kind of chemical detergent, and for carrying out cleaning skin care, most important functional component is surfactant,
The non-polar group simultaneously in surfactant molecule with hydrophilic polar group and oleophylic, when its addition is seldom,
The surface tension and light-liquid interfacial tension of solvent can be substantially reduced, and with lubrication, solubilising, emulsification, dispersion and washing etc.
Effect can make the dirt that hand is infected be quickly removed;Also containing some specific ingredients in the hand cleanser of part can rise
To disinfection, the effect of sterilization, such as staphylococcus aureus and Escherichia coli etc. that skin surface can be removed.Hand cleanser is general
The ingredients such as without phosphorus, aluminium, alkali, sodium alkyl benzene sulfonate, are in neutrality or alkalescent is easy to be connect by skin using the principle of mild decontamination
By.Hand cleanser is broadly divided into three classes, and one kind is common hand cleanser, a generic sterile products, and also special one kind belongs to heavy oil
Dirty hand cleanser.In addition, hand cleanser can also classify according to product odor type, such as lily odor type, lavender flavor type, rose fragrant
Type, chrysanthemum odor type etc..
Current market sales of hand cleanser mainly carries out bacteriostat degerming using chemical bactericide etc..These chemical substances are big
Part has physiological-toxicity, will also result in pollution to ecological environment, after these substances are drained by washing in sewage, passes through
It can be absorbed by certain organisms after the enrichment of the Nature, to cause ecocatastrophe.Some nontoxic fungicide, such as alcohol
Deng because can cause to stimulate to skin large dosage ofly, it is also not possible to apply in the washing products such as hand cleanser.If it is possible to
Develop some nontoxic, free of contamination green safe fungicide;It will can be very good to solve the problems, such as this.Contain in many Chinese medicines
There are the ingredients such as a large amount of alkaloid, polypeptide, polysaccharide with bactericidal antiphlogistic, these ingredients that can be used as in the washing products such as hand protection liquid
Fungicide use;But there are no such products to be developed currently on the market.
Invention content
It is this to wash one's hands the present invention provides a kind of strength degerming bacteriostatic hand sanitizer for problems of the prior art
Liquid has good decontamination performance of deoiling, and also has good bactericidal anti-inflammatory effects, pro-skin is not hurt hands, very green safe.
In order to achieve the above object, the present invention is achieved through the following technical solutions:
A kind of strength degerming bacteriostatic hand sanitizer, according to mass percent, hand cleanser includes following component:Anionic surface is lived
Property agent 7-10%, nonionic surface active agent 3-5%, ethyl alcohol 4-7%, glycerine 1.5-2.7%, disodium hydrogen phosphate-di(2-ethylhexyl)phosphate
Hydrogen sodium buffer solution 2.2-2.5%, composite hydrolytic enzyme 0.3-0.6%, strength bacteria remover 0.7-1.2%, pigment 0.2-0.3% are fragrant
Smart 0.05-0.1%, surplus are deionized water.
Preferably, according to mass percent, hand cleanser includes following component:Anion surfactant 7.8-9.2% is non-
Ionic surfactant 3.5-4.2%, ethyl alcohol 5-6%, glycerine 1.9-2.4%, disodium hydrogen phosphate-phosphate sodium dihydrogen buffer solution
2.3-2.4%, composite hydrolytic enzyme 0.4-0.5%, strength bacteria remover 0.9-1.2%, pigment 0.25-0.28%, essence 0.06-
0.08%, surplus is deionized water.
It is further preferred that according to mass percent, hand cleanser includes following component:Anion surfactant 8%, it is non-
Ionic surfactant 4%, ethyl alcohol 5.5%, glycerine 2.2%, disodium hydrogen phosphate-phosphate sodium dihydrogen buffer solution 2.4% are compound
Hydrolase 0.45%, strength bacteria remover 1.1%, pigment 0.27%, essence 0.07%, surplus are deionized water.
In the present invention, the preparation method of strength bacteria remover includes the following steps:
(1) according to mass fraction, by 11 parts of live body centipede, 3 parts of live body gold ring tiger head bee, 20 parts of living silkworm chrysalises are cold in liquid nitrogen
Freeze after device suddenly freezes and be ground into dry powder, by dry powder and pallas pit viper powder, cicada slough powder, toad powder according to 8:2:1:2 mass ratio mixing, is mixed
It closes in the sodium chloride solution for the 1.2g/ml that object is added to 8-10 times of volume and stirs to get dispersion liquid;
(2) phosphate buffer of 8.5wt% is added into dispersion liquid, the pH value for adjusting mixed liquor is 6.5-6.8, then
The mixing enzyme preparation containing lipase, nuclease, clostridiopetidase A of 2.5wt% is added into mixed liquor, with 38-40 DEG C of temperature enzyme
Solution reaction 45-60min obtains the first enzymolysis liquid, and the first enzymolysis liquid obtains the with the rotating speed high speed centrifugation of 10000-11000r/min
One supernatant is continued to employ;The pH value of precipitation is adjusted to 3.2-3.5, acidification 15-20min with hydrochloric acid, then by pH value adjustment
To 7.5-7.8, the proteolytic enzyme for adding 1.5wt% continues to digest 1-1.5h, the second enzymolysis liquid is obtained, by the second enzymolysis liquid
It centrifuges to obtain the second supernatant with the rotating speed of 3800-4500r/min;
(3) merge the first supernatant and the second supernatant, with the temperature low temperature cold less than -15 DEG C after supernatant is mixed
Freeze, lyophilized products slowly melt at room temperature, by solution with molecular cut off for the ultrafiltration membrance filter of 8000-10000 after, obtain institute
Active matter filtrate is needed, is evaporated under reduced pressure after active matter filtrate is concentrated, required first solid content is obtained;
(4) with 5:1:1:3:4:2 mass ratio weighs kuh-seng, corydlis bungeana, dandelion, Herba Andrographitis, Fructus Forsythiae and cordate houttuynia
Dry powder, by dry powder blend it is uniform after be added in Soxhlet reflux, using absolute ethyl alcohol as solvent refluxing extract 1-1.5h, weight
It extracts 2-3 times again, extracting solution is merged into postcooling to room temperature;
(5) polyvinylpyrrolidone of 0.3-0.5wt% is added into the extracting solution after merging, with 55-65 DEG C of temperature
1-2h is stirred, then product is handled with molecular cut off for the ultrafiltration membrance filter of 60000-70000, filtrate is obtained, by filtrate
It is evaporated under reduced pressure after concentration, obtains required second solid content;
(6) by the first solid content and the second solid content according to 5:1 mass ratio mixing, obtains required strength bacteria remover.
Wherein, the mass ratio of lipase, nuclease and clostridiopetidase A three is 1 in the mixed enzyme of step (2):3:6.
Reflux temperature in the Soxhlet reflux of step (4) is 48-53 DEG C.
Preferably, anion surfactant is fatty alcohol polyoxyethylene ether phosphate monoester, fatty alcohol polyoxyethylene ether sulphur
One kind in sour sodium and neopelex.
Preferably, nonionic surfactant is the double second of lauric monoethanolamide, ethylene glycol stearate and coconut oil
One kind in alkylolamides.
Preferably, alkali protease, lipase, amylase and cellulase are contained in composite hydrolytic enzyme.
The preparation method of hand cleanser provided by the invention is:
According to mass percent, deionized water is added in emulsifier and is heated to 65-75 DEG C, by anion surface active
Agent, nonionic surfactant and glycerine are added in reaction kettle, and it is uniform to be stirred well to material dispersion, then object in emulsifying kettle
The temperature of material is reduced to 43-46 DEG C, and strength bacteria remover, which is added in ethyl alcohol, to be uniformly dispersed, and dispersion liquid is added in emulsifying kettle, after
Disodium hydrogen phosphate-phosphate sodium dihydrogen buffer solution, is then added in emulsifying kettle, adjusts the pH value of material by continuous stirring 10-14min
It is added in emulsifying kettle to 7.5-8.2, then by composite hydrolytic enzyme, continues to stir 6-8min;Finally pigment and essence are added, stirred
3-5min is mixed, is sent in aging reactor, 2-3d is aged, filling and sealing obtains required product.
The present invention has following advantageous effect:
The type hand cleanser is using the compound of anion surfactant and nonionic surfactant as main cleaning
The factor, the pollutant that can be infected with hand is effectively cleaned, and the surfactant of the selection in the present invention has nothing
It is the characteristics of poison, pro-skin, easy rinsing, very safe.Enzymolysis compound in formula can to some obstinate organic pollutions into
Row decomposes, to play better cleaning effect;Buffer solution can provide best soda acid for enzyme digestion reaction and cleaning bacteria remover
Environment improves its activity;It is to play the role of handguard pro-skin that glycerine acts in component, reduces thorn of the hand cleanser to hand skin
Swash.An effect part for ethyl alcohol is the dispersant as special component, in addition can also play the role of sterilizing degerming.
Strength bacteria remover is used in the type hand cleanser, is from centipede, golden ring tiger head bee, silkworm chrysalis, pallas pit viper, cicada slough, toad etc.
It is extracted in the plant medicines material such as animal tcm and kuh-seng, corydlis bungeana, dandelion, Herba Andrographitis, Fructus Forsythiae and cordate houttuynia
's.Active ingredient includes mainly polypeptide, polysaccharide and some alkaloids substances;The sterilization of these ingredients, bacteriostasis
It is very good, and long-acting fungistatic effect can be formed with hand.In addition, the extraction process in through the invention obtains active principle
Purity it is higher;Most of all, this kind of bacteria remover is non-toxic to humans, it is very safe and healthy.
Specific implementation mode
The specific implementation mode of the present invention is further described with reference to embodiment, following embodiment is only used for more
Technical scheme of the present invention is clearly demonstrated, and not intended to limit the protection scope of the present invention.
The preparation method of strength bacteria remover includes the following steps in following embodiment:
(1) according to mass fraction, by 11 parts of live body centipede, 3 parts of live body gold ring tiger head bee, 20 parts of living silkworm chrysalises are cold in liquid nitrogen
Freeze after device suddenly freezes and be ground into dry powder, by dry powder and pallas pit viper powder, cicada slough powder, toad powder according to 8:2:1:2 mass ratio mixing, is mixed
It closes in the sodium chloride solution for the 1.2g/ml that object is added to 9 times of volumes and stirs to get dispersion liquid;
(2) phosphate buffer of 8.5wt% is added into dispersion liquid, the pH value for adjusting mixed liquor is 6.7, then to mixed
The mixing enzyme preparation containing lipase, nuclease, clostridiopetidase A that 2.5wt% is added in liquid is closed, with 39 DEG C of temperature enzyme digestion reaction
47min obtains the first enzymolysis liquid, and the first enzymolysis liquid obtains the first supernatant with the rotating speed high speed centrifugation of 11000r/min and continues to employ;It will
The pH value of precipitation is adjusted to 3.4, acidification 18min with hydrochloric acid, then by pH value adjustment to 7.7, adds the egg of 1.5wt%
White hydrolase continues to digest 1.3h, obtains the second enzymolysis liquid, the second enzymolysis liquid is centrifuged to obtain second with the rotating speed of 4000r/min
Supernatant;
(3) merge the first supernatant and the second supernatant, with the temperature low temperature cold less than -15 DEG C after supernatant is mixed
Freeze, lyophilized products slowly melt at room temperature, after the ultrafiltration membrance filter for being 9000 with molecular cut off by solution, obtain required activity
Object filtrate is evaporated under reduced pressure after concentrating active matter filtrate, obtains required first solid content;
(4) with 5:1:1:3:4:2 mass ratio weighs kuh-seng, corydlis bungeana, dandelion, Herba Andrographitis, Fructus Forsythiae and cordate houttuynia
Dry powder, by dry powder blend it is uniform after be added in Soxhlet reflux, using absolute ethyl alcohol as solvent refluxing extract 1.3h, repeat
Extracting solution is merged postcooling to room temperature by extraction 3 times;
(5) polyvinylpyrrolidone of 0.4wt% is added into the extracting solution after merging, 1- is stirred with 60 DEG C of temperature
Then product is handled with the ultrafiltration membrance filter that molecular cut off is 60000, obtains filtrate, depressurized and steam after filtrate is concentrated by 2h
Hair obtains required second solid content;
(6) by the first solid content and the second solid content according to 5:1 mass ratio mixing, obtains required strength bacteria remover.
Wherein, the mass ratio of lipase, nuclease and clostridiopetidase A three is 1 in the mixed enzyme of step (2):3:6.
Reflux temperature in the Soxhlet reflux of step (4) is 50 DEG C.
Embodiment 1
A kind of strength degerming bacteriostatic hand sanitizer, according to mass percent, hand cleanser includes following component:Anionic surface is lived
Property agent 7%, nonionic surface active agent 3%, ethyl alcohol 4%, glycerine 1.5%, disodium hydrogen phosphate-phosphate sodium dihydrogen buffer solution
2.2%, composite hydrolytic enzyme 0.3%, strength bacteria remover 0.7%, pigment 0.2%, essence 0.05%, surplus is deionized water.
Wherein, anion surfactant is fatty alcohol polyoxyethylene ether phosphate monoester.
Nonionic surfactant is lauric monoethanolamide.
Contain alkali protease, lipase, amylase and cellulase in composite hydrolytic enzyme.
The preparation method of hand cleanser provided in this embodiment is:
According to mass percent, deionized water is added in emulsifier and is heated to 65 DEG C, by anion surfactant,
Nonionic surfactant and glycerine are added in reaction kettle, and it is uniform to be stirred well to material dispersion, then material in emulsifying kettle
Temperature be reduced to 43 DEG C, strength bacteria remover, which is added in ethyl alcohol, to be uniformly dispersed, and dispersion liquid is added in emulsifying kettle, continues to stir
Disodium hydrogen phosphate-phosphate sodium dihydrogen buffer solution is then added in emulsifying kettle by 10min, adjusts the pH value of material to 7.5, then
Composite hydrolytic enzyme is added in emulsifying kettle, continues to stir 6min;Finally pigment and essence are added, 3min is stirred, is sent to
In aging reactor, it is aged 2d, filling and sealing obtains required product.
Embodiment 2
A kind of strength degerming bacteriostatic hand sanitizer, according to mass percent, hand cleanser includes following component:Anionic surface is lived
Property agent 10%, nonionic surface active agent 5%, ethyl alcohol 7%, glycerine 2.7%, disodium hydrogen phosphate-phosphate sodium dihydrogen buffer solution
2.5%, composite hydrolytic enzyme 0.6%, strength bacteria remover 1.2%, pigment 0.3%, essence 0.1%, surplus is deionized water.
Wherein, anion surfactant is sodium sulfate of polyethenoxy ether of fatty alcohol.
Nonionic surfactant is ethylene glycol stearate.
Contain alkali protease, lipase, amylase and cellulase in composite hydrolytic enzyme.
The preparation method of hand cleanser provided in this embodiment is:
According to mass percent, deionized water is added in emulsifier and is heated to 75 DEG C, by anion surfactant,
Nonionic surfactant and glycerine are added in reaction kettle, and it is uniform to be stirred well to material dispersion, then material in emulsifying kettle
Temperature be reduced to 46 DEG C, strength bacteria remover, which is added in ethyl alcohol, to be uniformly dispersed, and dispersion liquid is added in emulsifying kettle, continues to stir
Disodium hydrogen phosphate-phosphate sodium dihydrogen buffer solution is then added in emulsifying kettle by 14min, adjusts the pH value of material to 8.2, then
Composite hydrolytic enzyme is added in emulsifying kettle, continues to stir 8min;Finally pigment and essence are added, 5min is stirred, is sent to
In aging reactor, it is aged 3d, filling and sealing obtains required product.
Embodiment 3
A kind of strength degerming bacteriostatic hand sanitizer, according to mass percent, hand cleanser includes following component:Anionic surface is lived
Property agent 8%, nonionic surface active agent 4%, ethyl alcohol 5.5%, glycerine 2.2%, disodium hydrogen phosphate-phosphate sodium dihydrogen buffer solution
2.4%, composite hydrolytic enzyme 0.45%, strength bacteria remover 1.1%, pigment 0.27%, essence 0.07%, surplus is deionized water.
Wherein, anion surfactant is neopelex.
Nonionic surfactant is coconut oil di-methylcarbinol amide.
Contain alkali protease, lipase, amylase and cellulase in composite hydrolytic enzyme.
The preparation method of hand cleanser provided in this embodiment is:
According to mass percent, deionized water is added in emulsifier and is heated to 70 DEG C, by anion surfactant,
Nonionic surfactant and glycerine are added in reaction kettle, and it is uniform to be stirred well to material dispersion, then material in emulsifying kettle
Temperature be reduced to 45 DEG C, strength bacteria remover, which is added in ethyl alcohol, to be uniformly dispersed, and dispersion liquid is added in emulsifying kettle, continues to stir
Disodium hydrogen phosphate-phosphate sodium dihydrogen buffer solution is then added in emulsifying kettle by 13min, adjusts the pH value of material to 7.8, then
Composite hydrolytic enzyme is added in emulsifying kettle, continues to stir 7min;Finally pigment and essence are added, 4min is stirred, is sent to
In aging reactor, it is aged 2d, filling and sealing obtains required product.
Performance test
1, with reference to United States Pharmacopeia USP32<51>Method in antimicrobial preservation efficacy test disappears to antibacterial in the present embodiment
The bacteriostasis property of scorching composition is detected, and it includes gold-coloured staphylococci, Escherichia coli and black-koji mould to test the strain used,
Test result is as follows for bacteriostatic test:102-102
Table 1:The bacteriostatic experiment result of inhibiting bacteria and diminishing inflammation composition in the present embodiment
It analyzes the above experimental result to find, the inhibiting bacteria and diminishing inflammation composition used in the present invention is to gold-coloured staphylococci, large intestine
Bacillus and the common bacterium of black-koji mould three have an apparent fungistatic effect, especially to the inhibiting rate of gold-coloured staphylococci compared with
Height, inhibiting effect are quickly apparent.
2, test evaluation is carried out to the using effect of the present embodiment hand cleanser, 50 is selected in the test crowd of different occupation
A sample tries out the hand cleanser products 1 month, and count its for the cleaning effect of hand cleanser, pro-skin hand protecting function, it is water-saving easily
Drift performance is evaluated, and obtains evaluating statistical result as follows:
Table 2:The effect assessment of hand cleanser in the present embodiment
It analyzes the above experimental result and finds that nearly all tester approves the cleaning effect of product of the present invention, in parent
In skin performance, 90% or more tester expresses one's approval, and is only no more than 10 testers and indicates that pro-skin effect is unknown
It is aobvious;And the people for accepting the water-saving easy rinsing performance of hand cleanser of the present invention is more than 88%, therefore it may be concluded that the present invention's washes one's hands
The cleaning effect of liquid protrudes, and has preferable pro-skin performance and easy rinsing performance.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, although with reference to aforementioned reality
Applying example, invention is explained in detail, for those skilled in the art, still can be to aforementioned each implementation
Technical solution recorded in example is modified or equivalent replacement of some of the technical features.All essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (10)
1. a kind of strength degerming bacteriostatic hand sanitizer, which is characterized in that according to mass percent, the hand cleanser includes such as the following group
Point:Anion surfactant 7-10%, nonionic surface active agent 3-5%, ethyl alcohol 4-7%, glycerine 1.5-2.7%, phosphoric acid hydrogen
Disodium-phosphate sodium dihydrogen buffer solution 2.2-2.5%, composite hydrolytic enzyme 0.3-0.6%, strength bacteria remover 0.7-1.2%, pigment 0.2-
0.3%, essence 0.05-0.1%, surplus is deionized water.
2. a kind of strength degerming bacteriostatic hand sanitizer according to claim 1, it is characterised in that:According to mass percent, institute
It includes following component to state hand cleanser:Anion surfactant 7.8-9.2%, nonionic surface active agent 3.5-4.2%, ethyl alcohol
5-6%, glycerine 1.9-2.4%, disodium hydrogen phosphate-phosphate sodium dihydrogen buffer solution 2.3-2.4%, composite hydrolytic enzyme 0.4-0.5%, strength
Bacteria remover 0.9-1.2%, pigment 0.25-0.28%, essence 0.06-0.08%, surplus are deionized water.
3. a kind of strength degerming bacteriostatic hand sanitizer according to claim 2, it is characterised in that:According to mass percent, institute
It includes following component to state hand cleanser:Anion surfactant 8%, nonionic surface active agent 4%, ethyl alcohol 5.5%, glycerine
2.2%, disodium hydrogen phosphate-phosphate sodium dihydrogen buffer solution 2.4%, composite hydrolytic enzyme 0.45%, strength bacteria remover 1.1%, pigment
0.27%, essence 0.07%, surplus is deionized water.
4. a kind of strength degerming bacteriostatic hand sanitizer according to claim 1, it is characterised in that:The system of the strength bacteria remover
Preparation Method includes the following steps:
(1)According to mass fraction, by 11 parts of live body centipede, 3 parts of live body gold ring tiger head bee, 20 parts of living silkworm chrysalises are filled in liquid nitrogen frozen
It is ground into dry powder after setting anxious freeze, by dry powder and pallas pit viper powder, cicada slough powder, toad powder according to 8:2:1:2 mass ratio mixing, mixture
It is added in the sodium chloride solution of the 1.2g/ml of 8-10 times of volume and stirs to get dispersion liquid;
(2)The phosphate buffer of 8.5wt% is added into dispersion liquid, the pH value for adjusting mixed liquor is 6.5-6.8, then to mixed
The mixing enzyme preparation containing lipase, nuclease, clostridiopetidase A that 2.5wt% is added in liquid is closed, it is anti-with 38-40 DEG C of temperature enzymolysis
45-60min is answered to obtain the first enzymolysis liquid, the first enzymolysis liquid is obtained with the rotating speed high speed centrifugation of 10000-11000r/min on first
Clear liquid is continued to employ;The pH value of precipitation is adjusted to 3.2-3.5, acidification 15-20min with hydrochloric acid, then extremely by pH value adjustment
7.5-7.8, add 1.5wt% proteolytic enzyme continue digest 1-1.5h, obtain the second enzymolysis liquid, by the second enzymolysis liquid with
The rotating speed of 3800-4500r/min centrifuges to obtain the second supernatant;
(3)Merge the first supernatant and the second supernatant, with the temperature cryogenic freezing less than -15 DEG C after supernatant is mixed, freezes
Dry slowly melts at room temperature, by solution with molecular cut off for the ultrafiltration membrance filter of 8000-10000 after, obtain required work
Property object filtrate, will active matter filtrate concentration after be evaporated under reduced pressure, obtain needed for the first solid content;
(4)With 5:1:1:3:4:2 mass ratio weighs kuh-seng, corydlis bungeana, dandelion, Herba Andrographitis, Fructus Forsythiae and the dry powder of cordate houttuynia,
By dry powder blend it is uniform after be added in Soxhlet reflux, using absolute ethyl alcohol as solvent refluxing extract 1-1.5h, repetition carry
It takes 2-3 times, extracting solution is merged into postcooling to room temperature;
(5)The polyvinylpyrrolidone of 0.3-0.5wt% is added into the extracting solution after merging, 1- is stirred with 55-65 DEG C of temperature
Then product is handled with molecular cut off for the ultrafiltration membrance filter of 60000-70000, filtrate is obtained, after filtrate is concentrated by 2h
It is evaporated under reduced pressure, obtains required second solid content;
(6)By the first solid content and the second solid content according to 5:1 mass ratio mixing obtains the required antibacterial disinfectant of biology.
5. a kind of strength degerming bacteriostatic hand sanitizer according to claim 4, it is characterised in that:The step(2)Mixing
The mass ratio of lipase, nuclease and clostridiopetidase A three is 1 in enzyme:3:6.
6. a kind of strength degerming bacteriostatic hand sanitizer according to claim 4, it is characterised in that:The step(4)Soxhlet
Reflux temperature in reflux is 48-53 DEG C.
7. a kind of strength degerming bacteriostatic hand sanitizer according to claim 1, it is characterised in that:The anion surface active
Agent is one in fatty alcohol polyoxyethylene ether phosphate monoester, sodium sulfate of polyethenoxy ether of fatty alcohol and neopelex
Kind.
8. a kind of strength degerming bacteriostatic hand sanitizer according to claim 7, it is characterised in that:The non-ionic surface active
Agent is one kind in lauric monoethanolamide, ethylene glycol stearate and coconut oil di-methylcarbinol amide.
9. a kind of strength degerming bacteriostatic hand sanitizer according to claim 1, it is characterised in that:Contain in the enzymolysis compound
There are alkali protease, lipase, amylase and cellulase.
10. according to a kind of strength degerming bacteriostatic hand sanitizer described in any one of claim 1-9, which is characterized in that described to wash
The preparation method of hand liquid is:
According to mass percent, deionized water is added in emulsifier and is heated to 65-75 DEG C, by anion surfactant,
Nonionic surfactant and glycerine are added in reaction kettle, and it is uniform to be stirred well to material dispersion, then material in emulsifying kettle
Temperature be reduced to 43-46 DEG C, strength bacteria remover, which is added in ethyl alcohol, to be uniformly dispersed, and dispersion liquid is added in emulsifying kettle, continue
Stir 10-14min, then disodium hydrogen phosphate-phosphate sodium dihydrogen buffer solution be added in emulsifying kettle, adjust the pH value of material to
7.5-8.2, then composite hydrolytic enzyme is added in emulsifying kettle, continue to stir 6-8min;Finally pigment and essence are added, stirring
3-5min is sent in aging reactor, is aged 2-3d, and filling and sealing obtains required product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810782756.4A CN108685733A (en) | 2018-07-17 | 2018-07-17 | A kind of strength degerming bacteriostatic hand sanitizer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201810782756.4A CN108685733A (en) | 2018-07-17 | 2018-07-17 | A kind of strength degerming bacteriostatic hand sanitizer |
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ID=63850679
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| CN201810782756.4A Withdrawn CN108685733A (en) | 2018-07-17 | 2018-07-17 | A kind of strength degerming bacteriostatic hand sanitizer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110721100A (en) * | 2019-11-13 | 2020-01-24 | 贺晋巍 | Sterilization hand sanitizer |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7589051B2 (en) * | 2004-04-08 | 2009-09-15 | Hercules Incorporated | Cationic, oxidized polysaccharides in conditioning applications |
| CN102846496A (en) * | 2012-09-18 | 2013-01-02 | 江苏雪豹日化有限公司 | Biological complex-enzyme bacteriostatic skin-care hand sanitizer and preparation method thereof |
| CN106691950A (en) * | 2017-02-27 | 2017-05-24 | 陕西理工学院 | Selfheal-containing Chinese herbal hand sanitizer and preparation method |
-
2018
- 2018-07-17 CN CN201810782756.4A patent/CN108685733A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7589051B2 (en) * | 2004-04-08 | 2009-09-15 | Hercules Incorporated | Cationic, oxidized polysaccharides in conditioning applications |
| CN102846496A (en) * | 2012-09-18 | 2013-01-02 | 江苏雪豹日化有限公司 | Biological complex-enzyme bacteriostatic skin-care hand sanitizer and preparation method thereof |
| CN106691950A (en) * | 2017-02-27 | 2017-05-24 | 陕西理工学院 | Selfheal-containing Chinese herbal hand sanitizer and preparation method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110721100A (en) * | 2019-11-13 | 2020-01-24 | 贺晋巍 | Sterilization hand sanitizer |
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Application publication date: 20181023 |