CN108685096A - A kind of soybean essence extracting solution liver-protecting product - Google Patents
A kind of soybean essence extracting solution liver-protecting product Download PDFInfo
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- CN108685096A CN108685096A CN201710216628.9A CN201710216628A CN108685096A CN 108685096 A CN108685096 A CN 108685096A CN 201710216628 A CN201710216628 A CN 201710216628A CN 108685096 A CN108685096 A CN 108685096A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract
The invention discloses a kind of soybean essence extracting solution liver-protecting products, belong to biotechnology.Soybean essence wink-dry under high-frequency microwave effect gasifies in the present invention, and soybean Essence is obtained by condensing recovery.Gained soybean Essence can promote vital movement forward reaction, promote fat metabolism, improve immunity of organisms;Cholesterol is reduced, hepatopathy is prevented.The hepatic injury mouse tested, people are participated in after taking soybean Essence for a period of time, hepatocellular injury is obtained for apparent reparation.
Description
Technical field
The present invention relates to a kind of soybean essence extracting solution liver-protecting products, belong to biotechnology.
Background technology
Soybean (scientific name:Glycine max) common name soya bean.Soybean is one of important cereal crops of China, is had 5,000 years
Cultivation history, Gu claim bean, and Northeast China is main producing region, is a kind of crop that its seed contains abundant phytoprotein.Soybean is most
It is commonly used to do various bean product, squeezes soya-bean oil, make soy sauce and extract protein.Bean dregs or the soybean for wearing into coarse powder are also commonly used for
Poultry and livestock feed.
The defect of the existing method using soybean:Now with the various bean product of soybean, squeeze soya-bean oil, make soy sauce etc. it is general
Logical food also has the high value added products such as soybean protein, isoflavones and the lecithin inside refinement soybean.But as general
Opposite added value is not high for logical food, for refining legumin, isoflavones and the lecithin of high added value, mainstream and
Ripe technique is all that chemical reagent assisted extraction is added, the products such as isoflavones and lecithin of extraction bioactivity by
Very big influence can only refine single composition every time, and state-of-the-art supercritical liquid extraction technique, can solve biological work
Property the problem of, but because cost is high the problem of extraction yield.These cannot meet people using the method for soybean
Increasingly diversified consumption demand.
Liver is maximum organ in human body viscera, is an organ in body based on metabolic function.Common liver
Disease includes hepatitis B, hepatitis A, hepatitis, hepatic sclerosis, fatty liver, liver cancer, alcoholic liver etc., since hepatopathy is a kind of common harmfulness
Great disease, and early stage, without apparent symptom, therefore, once finding illness, often the state of an illness has developed to more serious journey
Degree.Therefore, the protection of liver is focused on daily.
The health products of liver protecting become one of highest product of current attention rate.Natural plant extracts are because of its degree of safety
High, Small side effects and be increasingly taken seriously, with liver protecting product that natural plant extracts are main functional components also by
To the favor of consumers in general.But these products, most offer limited effectiveness.
Invention content
Present invention firstly provides a kind of soybean essence extracting solution liver-protecting product, the liver-protecting product includes containing soybean essence
The health food and drug of magnificent liquid.
The health food includes the tea containing soybean Essence, wine, honeybee product, drink, Tang Pin, fresh juice, herbal cuisine etc..
The drug is the auxiliary material received on medicament to be not added with or be added, according to corresponding using soybean Essence as active constituent
Preparation is made in the preparation method of dosage form.The dosage form include solid powder, aqueous solution, alcoholic solution, lotion, facial mask, cataplasm,
Injection, drip solution, powder-injection, granule, tablet, electuary, powder, oral solution, sugar-coat agent, film coated tablet, Enteric coated tablets
Agent, capsule, hard capsule, soft capsule, mouth containing agent, granule, pill, paste, sublimed preparation, spray, pill, disintegration
Agent, pellet are collapsed in agent, mouth.
The preparation method of the soybean Essence mainly includes the following steps that:
(1) material pre-treatment:The impurity such as dust are removed into soybean screening, and are arranged in the same size to specification;
(2) ready material is put into microwave reaction kettle, is handled under the microwave power of 200KHZ-2500MHZ, microwave
Distillation or microwave, which gasify, soybean essence.
In one embodiment of the invention, step (2) is that ready material is put into microwave reaction kettle,
1~2min is handled under the microwave power of 1000KHz-2500MHz, microwave distillation or microwave, which gasify, soybean essence.
In one embodiment of the invention, step (2) is that ready material is put into microwave reaction kettle,
1~2min is handled under the microwave power of 1500KHz-2500MHz, microwave distillation or microwave, which gasify, soybean essence.
In one embodiment of the invention, step (2) is that ready material is put into microwave reaction kettle,
1~2min is handled under the microwave power of 2000KHz-2500MHz, microwave distillation or microwave, which gasify, soybean essence.
In one embodiment of the invention, step (2) is that ready material is put into microwave reaction kettle,
1~2min is handled under the microwave power of 1MHz-2500MHz, microwave distillation or microwave, which gasify, soybean essence.
In one embodiment of the invention, step (2) is that ready material is put into microwave reaction kettle,
1~2min is handled under the microwave power of 10MHz-2500MHz, microwave distillation or microwave, which gasify, soybean essence.
In one embodiment of the invention, step (2) is that ready material is put into microwave reaction kettle,
1~2min is handled under the microwave power of 100MHz-2500MHz, microwave distillation or microwave, which gasify, soybean essence.
In one embodiment of the invention, step (2) is that ready material is put into microwave reaction kettle,
1~2min is handled under the microwave power of 1000MHz-2500MHz, microwave distillation or microwave, which gasify, soybean essence.
In one embodiment of the invention, step (2) is that ready material is put into microwave reaction kettle,
1~2min is handled under the microwave power of 2500MHz, microwave distillation or microwave, which gasify, soybean essence.
Soybean Essence provided by the invention can promote vital movement forward reaction, promote fat metabolism, improve body
Immunity;Cholesterol is reduced, hepatopathy is prevented.Participate in the hepatic injury mouse of experiment, sufferer is taking soybean Essence for a period of time
Afterwards, hepatic injury has obtained apparent reparation.
Description of the drawings
Fig. 1 mouse livers, Figure 1A are the hepatic tissue photo of blank group, and Figure 1B is the hepatic tissue photo of model group, and Fig. 1 C are
The hepatic tissue photo for the treatment of group.
Fig. 2 mouse protect liver test results, Fig. 2A are the hepatic tissue electromicroscopic photograph of blank group, and Fig. 2 B are the hepatic tissue of model group
Electromicroscopic photograph, Fig. 2 C are the hepatic tissue electromicroscopic photograph for the treatment of group.
Specific implementation mode
The preparation method of 1 soybean Essence of embodiment
(1) material pre-treatment:The impurity such as dust are removed into soybean screening, and are arranged in the same size to specification;
(2) ready material is put into microwave reaction kettle, 1min, microwave steam is handled under the microwave power of 2000MHz
It evaporates or microwave gasifies and soybean essence.
Substance distills or gasifies under high-frequency microwave effect in soybean, and soybean Essence is obtained by condensing recovery.5kg is big
Beans can go out 500g Essences.
The safety feature test of 2 soybean Essence of embodiment
Using method is directly drunk, 15 male white mouses and 15 females of the weight range in 20g to 23g are chosen
Small white mouse is randomly divided into 3 groups, and one of which does not give soybean Essence, and one group is given 5mL soybean Essences every 6h, also
One group of each 6h gives 1mL soybean Essences, persistently feeds 6 months.The result shows that test animal is small without the phenomena of mortality in 1 week
Mouse activity is normal, with control group indifference;Animal is tested at 6 months without the phenomena of mortality, mouse activity is normal.Pass through forced swimming
Experiment, compared to the control group, the swimming time of test mice is obviously prolonged, performance strength slightly than control group.
3 mouse protect liver of embodiment is tested
The female small white mouse of 35 male white mouses and 35 of the weight range in 20g to 23g is chosen, is randomly divided into 7
Group.Wherein 1 group is blank group, normal to feed;3 groups are treatment group, and paracetamol, carbon tetrachloride, alcohol is respectively adopted and makees
Mouse liver injury model is prepared for derivant, then gives 1mL soybean Essences every 6h;3 groups are model group, are respectively adopted pair
Paracetamol, carbon tetrachloride, alcohol prepare mouse liver injury model as derivant, then give 1mL water every 6h.Continue
After feeding 1 month, the results are shown in Figure 1, and treatment group's human consumption soybean essence liquid energy preferably protects hepatic tissue, hepatic tissue to be shown as
Appearance is ruddy, glossy, it is seen that slight point;The results are shown in Figure 2 for Electronic Speculum, and the hepatic tissue mitochondria for the treatment of group is intact, has
Slight color aggravates, but liver cell is intact, and Serologic detection, which also turns out, has no that apparent liver function level changes.
Clinical observation curative effect of the embodiment 4 to people's chronic hepatitis B
The standard of curative effect evaluation:
With reference to Chinese Medical Association's infectious disease and parasitic disease branch, hepatopathy association Xi'an meeting joint is revised"It is viral
Hepatitis control prece"The clinical research that virus hepatitis is treated with national drug Surveillance Authority (2002) new Chinese medicine is instructed
Principle standard:
1. clinic control:Clinical symptoms disappear, and liver function is normal, and surface antigen is turned out cloudy or surface antibody is positive, liver and gall spleen
Color ultrasound is without exception, and HBV-DNA is (quantitative) to be less than 103.
2. effective:Clinical symptoms disappear or slightly, liver function is normal, and e antigens are turned out cloudy, and liver and gall spleen color ultrasound is without exception or slight
Abnormal, HBV-DNA is (quantitative) to be less than 103.
3. effectively:Clinical symptom relief, the hepatic disorder ultrasound diagnosis state of an illness index standard 1 to 2 grade of improvement.
4. invalid:Do not adhere to treating, it is lost to follow-up, deteriorate, it is dead.
Therapy:It is randomly divided into 2 groups, every group of 30 people, pretherapy and post-treatment each comprehensive review symptom, sign, a liver function
Quan Xiang, immunoglobulin, blood, routine urinalysis, various viral antigen physical examination surveys, liver and gall spleen B ultrasound.Board compound amino is given and pacified to control group
Sour capsule (8-11) (specification:0.35g/, Shenzhen Wanhe Pharmaceutical Co., Ltd.), 2 tablets each time, 3 times a day;Treatment group is to this hair
Bright soybean essence extracting solution takes orally 30ml, 2 times a day every time.
The course for the treatment of:2 months as a treatment course;
After 30 patients for the treatment of group take 2 courses for the treatment of of soybean Essence of the preparation of embodiment 1, clinical cure 6 accounts for
20.0%, effective 9,30.0% is accounted for, effective 12,40.0% is accounted for, invalid 3, accounts for 10%.Total effective rate is 90%.Details
It is shown in Table 1,2.
Table 1
Table 2
Although the present invention has been described by way of example and in terms of the preferred embodiments, it is not limited to the present invention, any to be familiar with this skill
The people of art can do various change and modification, therefore the protection model of the present invention without departing from the spirit and scope of the present invention
Enclosing be subject to what claims were defined.
Claims (8)
1. a kind of liver-protecting product, which is characterized in that contain soybean Essence;The soybean Essence be soybean materials are put into it is micro-
Wave reaction kettle is handled under the microwave power of 200KHz-2500MHz, and microwave distillation or microwave, which gasify, soybean essence.
2. a kind of liver-protecting product according to claim 1, which is characterized in that including health food and drug.
3. a kind of liver-protecting product according to claim 1 or 2, which is characterized in that be the soup containing soybean Essence, drink
Material, herbal cuisine, including tea, wine, honeybee product, drink, Tang Pin, fresh juice, herbal cuisine etc..
4. a kind of liver-protecting product according to claim 1 or 2, which is characterized in that be drug, be with soybean Essence be live
Property ingredient, is not added with or is added the auxiliary material received on medicament, preparation is made according to the preparation method of corresponding dosage form.
5. a kind of liver-protecting product according to claim 4, which is characterized in that the dosage form of the preparation includes solid powder
End, aqueous solution, alcoholic solution, lotion, facial mask, cataplasm, injection, drip solution, powder-injection, granule, tablet, electuary, powder,
Oral solution, sugar-coat agent, film coated tablet, enteric coated tablet, capsule, mouth containing agent, granule, pill, paste, sublimed preparation, spraying
Agent, pill, mouth collapse agent, pellet.
6. a kind of method preparing any liver-protecting product of Claims 1 to 5, which is characterized in that be put into soybean materials micro-
Wave reaction kettle is handled under the microwave power of 200KHz-2500MHz, and microwave distillation or microwave, which gasify, soybean essence.
7. according to the method described in claim 6, it is characterized in that, mainly including the following steps that:
(1) material pre-treatment:The impurity such as dust are removed into soybean screening, and are arranged in the same size to specification;
(2) ready material is put into microwave reaction kettle, 1~2min is handled under the microwave power of 1000KHz-2500MHz,
Microwave distillation or microwave, which gasify, soybean essence.
8. the method described according to claim 6 or 7, which is characterized in that it is characterized in that, step (2) is by ready object
Material is put into microwave reaction kettle, and 1~2min, microwave distillation or microwave gasification are handled under the microwave power of 1000MHz-2500MHz
Go out soybean essence.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710216628.9A CN108685096A (en) | 2017-04-05 | 2017-04-05 | A kind of soybean essence extracting solution liver-protecting product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710216628.9A CN108685096A (en) | 2017-04-05 | 2017-04-05 | A kind of soybean essence extracting solution liver-protecting product |
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| Publication Number | Publication Date |
|---|---|
| CN108685096A true CN108685096A (en) | 2018-10-23 |
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ID=63841986
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710216628.9A Pending CN108685096A (en) | 2017-04-05 | 2017-04-05 | A kind of soybean essence extracting solution liver-protecting product |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102613567A (en) * | 2012-04-17 | 2012-08-01 | 孙震 | Soybean peptide nutrient solution and preparation method and application thereof |
| CN103772481A (en) * | 2014-02-10 | 2014-05-07 | 孟祥军 | Continuous soybean active peptide extraction machine |
-
2017
- 2017-04-05 CN CN201710216628.9A patent/CN108685096A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102613567A (en) * | 2012-04-17 | 2012-08-01 | 孙震 | Soybean peptide nutrient solution and preparation method and application thereof |
| CN103772481A (en) * | 2014-02-10 | 2014-05-07 | 孟祥军 | Continuous soybean active peptide extraction machine |
Non-Patent Citations (2)
| Title |
|---|
| 张桂英，等: "大豆多肽对小鼠酒精性肝损伤的作用研究", 《实用预防医学》 * |
| 戚颖欣，等: "大豆多肽对小鼠急性肝损伤保护作用的研究", 《食品科学》 * |
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| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181023 |