CN108671165A - 一种治疗女性更年期综合征的中药汤剂 - Google Patents
一种治疗女性更年期综合征的中药汤剂 Download PDFInfo
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Abstract
本发明涉及一种治疗女性更年期综合征的中药汤剂,属中草药技术领域。它由炒枣仁、茯苓、炙远志、生地、炒白芍、当归、浮小麦、知母、柴胡、川芎、丹参、桃仁、红花、甘草等十四味中药原料制成。本发明以炒枣仁、茯苓、炙远志为君药,养心安神,益智敛汗;以生地、炒白芍、当归、浮小麦、知母和柴胡为臣药,滋阴养心,清心除烦,止汗;以川芎、丹参、桃仁和红花为佐药,活血调血,祛瘀止痛;以甘草为使药,清热解毒,调和诸药。本发明能够较快较好的缓解更年期综合征患者的病症,临床治愈率得到显著提高,无任何毒副作用,其制备方法简单、易操作,较好的保持了原料药的有效成分,服用方便,特别适用于女性更年期综合征患者的治疗。
Description
技术领域
本发明涉及一种治疗女性更年期综合征的中药汤剂,属中草药技术领域。
背景技术
围绝经期综合征是指妇女绝经前后由于雌激素水平下降所致的以自主神经系统功能紊乱为主,伴有神经心理症状的一组症候群,如月经变化、面色潮红、心悸、失眠、乏力、抑郁、多虑、情绪不稳定,易激动,注意力难于集中等,称为“更年期综合征”。更年期综合征发病年龄大多在45~55岁之间,也有提前、退后或延长者。更年期综合征是一种阶段性疾病,目前更年期综合征的治疗方法有:一、性激素疗法,即雌/孕激素替代疗法。该方法一般为口服雌激素、尼尔雌醇、甲基睾丸等,但是该治疗方法常常导致患者出现如乳房胀痛、多毛、水肿、油脂分泌增加及胃肠道功能紊乱等不良反应。二、药物疗法,即服用α2受体激动剂、β肾上腺素能阻断剂、镇静-抗焦虑剂和抗抑郁剂等。但是这些药物仅仅是针对更年期综合症的某一症状来施药的,无法在整体上对患者病情起到调节作用,并且容易对更年期的妇女造成其他的伤害。
发明内容
本发明的目的在于:提供一种能够养心安神,滋阴活血,益气健脾、疏肝解郁,缓解更年期综合征女性失眠,潮热,出汗,烦躁等症状,具有治疗效果显著、安全性高、无毒副作用的治疗女性更年期综合征的中药汤剂。
本发明的技术方案是:
一种治疗女性更年期综合征的中药汤剂,其特征在于:它由下述重量份的中药原料制成:
炒枣仁 25~35 茯苓 10~20 川芎 5~15
知母 10~20 丹参 10~20 柴胡 5~15
生地 10~20 炒白芍 2~8 浮小麦 15~25
当归 10~20 桃仁 5~15 红花 5~15
炙远志 10~20 甘草 3~9。
所述的一种治疗女性更年期综合征的中药汤剂,其中各原料的重量配比是:
炒枣仁 28~32 茯苓 13~17 川芎 8~12
知母 12~18 丹参 13~17 柴胡 8~12
生地 12~18 炒白芍 4~6 浮小麦 18~22
当归 12~18 桃仁 8~12 红花 8~12
炙远志 12~18 甘草 5~7。
所述的一种治疗女性更年期综合征的中药汤剂,其中各原料的重量配比是:
炒枣仁 30 茯苓 15 川芎 10
知母 15 丹参 15 柴胡 10
生地 15 炒白芍 5 浮小麦 20
当归 15 桃仁 10 红花 10
炙远志 15 甘草 6。
该治疗女性更年期综合征的中药汤剂的制备方法为:按上述重量份称取中药原料,并按原料药与水的重量比1:6的比例加水煎煮,煎煮两遍,头煎:按比例加凉水后,先用大火煮开,在用文火熬煮30分钟,起锅滤汁;二煎:在头煎药渣中再加头煎用量的凉水,再次用大火煮开后,再用文火熬煮30分钟,然后起锅滤汁,将两次煎出的药汁混合,即得治疗女性更年期综合征的中药汤剂成品,将上述中药汤剂成品分装到200 ml的药瓶内,在0-3℃的温度下保存备用,保存期为1个月,服用时将药瓶放入70-80℃的热水中加热15分钟即可服用。
用法与用量:
每日早饭、中饭、晚饭后半小时进行温服,一日三次,每次服用200 ml,连续服用2周为一疗程。
本发明各组分原料的药性特点及功效如下:
炒枣仁:甘、酸、平。归心、肝、胆经。养肝,宁心,安神,敛汗。《本草纲目》:“其仁甘而润,故熟用疗胆虚不得眠,烦渴虚汗之证。”
茯苓:甘、淡、平。归心、脾、肾经。利水渗湿,健脾宁心。《本草衍义》:“茯苓,行水之功多,益心脾不可阙也。”
炙远志:苦、辛、温。归心、肾、肺经。安神益智,祛痰开窍,消散痈肿。《名医别录》:“定心气,止惊悸,益精,去心下膈气,皮肤中热,面目黄。”
生地黄:性寒,味甘。归心经、肝经、肾经。清热凉血、养阴、生津。《本草汇言》记载“生地,为补肾要药,益阴上品,故凉血补血有功……又治胎产劳伤,皆血之愆,血得其养,则胎产获安。”
炒白芍:性微寒、味苦、酸。归肝经、脾经。平肝止痛、养血调经、敛阴止汗。《药性赋》:“白芍,扶阳气大除腹痛,收阴气陡健脾经。”
当归:甘、辛、温。归肝、心、脾经。补血调经,活血止痛,润肠通便。《医学起源》:“当归,气温味甘,能和血补血。”
浮小麦:甘、凉。归心经。固表止汗,益气,除热。《本草纲目》:“益气除热,止自汗盗汗,骨蒸劳热,妇人劳热。”
柴胡:苦、辛、微寒。归肝、胆经。解表退热,疏肝解郁,升举阳气。《本草纲目》:“妇人热入血室,经水不调。”
川芎:辛、温。归肝、胆、心包经。《本草汇言》:“川芎,上行头目,下调经水,中开郁结,血中气药……味辛性阳,气善走窜而无阴凝粘滞之态,虽入血分,又能去一切风,调一切气。”
知母:苦、甘、寒。归肺、胃、肾经。清热泻火,生津润燥。《用药法象》:“泻无根之肾火,疗有汗之骨蒸,止虚劳之热,滋化源之阴。”
丹参:苦、微寒。归心、心包、肝经。活血调经,祛瘀止痛,凉血消痈,除烦安神。《日华子本草》:“养血定志,通理关节,治冷热劳,骨节烦痛,四肢不遂。”
桃仁:苦、甘、平。归心、甘、大肠经。活血祛瘀,润肠通便,止咳平喘。《珍珠囊》:“治血结,血秘,血燥,通润大便,破蓄血。”
红花:辛、温。归心、肝经。活血通经,祛瘀止痛。《本草汇言》:“红花,破血、行血、和血、调血之药也。”
甘草:性平,味甘。归心经、胃经、脾经、肺经。补脾益气、止咳祛痰、缓急定痛、调和药性。《本草汇言》:“甘草,和中益气,补虚解毒之药也。”
上述各原料中:炒枣仁、茯苓和炙远志为君药;生地、炒白芍、当归、浮小麦、知母和柴胡为臣药;川芎、丹参、桃仁和红花为佐药;甘草为使药。
本发明的治病机理是:以炒枣仁、茯苓、炙远志为君药,养心安神,益智敛汗。以生地、炒白芍、当归、浮小麦、知母和柴胡为臣药,滋阴养心,清心除烦,止汗。以川芎、丹参、桃仁和红花为佐药,活血调血,祛瘀止痛。以甘草为使药,清热解毒,调和诸药。诸药合用,能够起到养心安神,滋阴活血,益气健脾、疏肝解郁之功效,对于肾阴肾阳两虚,伴有肝郁血虚所致的更年期综合征的女性患者具有显著疗效。
本发明的有益效果在于:
本发明经过多年的临床实践,根据中医辩证论治和标本兼治的原则,采用炒枣仁、茯苓、炙远志等十四味中药的综合协同作用,具有养心安神,滋阴活血,益气健脾、疏肝解郁的功效,能够较快较好的缓解更年期综合征患者的病症,临床治愈率得到显著提高,无任何毒副作用,其制备方法简单、易操作,较好的保持了原料药的有效成分,服用方便,特别适用于女性更年期综合征患者的治疗。
为了说明本发明对治疗女性更年期综合征的疗效,通过对100例女性患者进行临床观察,其临床数据如下:
一、一般数据:
共收治女性门诊患者100例,年龄在45~55岁之间,其中45~50岁60例,50~55岁40例,病程最长10年,最短3个月,患者均有不同程度的烘热、汗出、烦躁易怒、精神倦怠、头昏目眩、耳鸣心悸、失眠健忘、腰背酸痛、形寒肢冷等症状,排除了“甲亢”及脏腑器官器质性病变。
将上述更年期综合征女性患者随机分成治疗组和对照组,治疗组为50例,其中45~50岁30例,50~55岁20例,对照组为50例,其中45~50岁30例,50~55岁20例,治疗组和对照组两组病例的病程、症状轻重程度基本一致,无显著差异,具有可比性。
二、治疗方法
治疗组:服用本发明中药汤剂,每日早饭、中饭、晚饭后半小时进行温服本发明中药汤剂,一日三次,每次服用200 ml,服用2周为一疗程。
对照组:激素替代疗法,服用戊酸雌二醇片1mg×24片;用法:每次1片,一天一次,饭后服,三周为一疗程。
三、疗效评定标准:
1、治愈:失眠,潮热,出汗,烦躁症状消失,自我感觉舒适。
2、好转:失眠,潮热,出汗,烦躁症状减轻。
3、无效:失眠,潮热,出汗,烦躁症状无明显变化。
四、临床观察数据统计表:
治疗组与对照组的疗效结果表明,采用本发明对患有更年期综合征的女性患者进行治疗,总有效率达到94%,治愈率可达72%,总有效率和痊愈率均显著高于采用的对照组的比例。另一方面,治疗组采用中药治疗性质比较温和,对身体没有影响,副作用小,这也是采用西药治疗无法比拟的。
具体实施方式
下面结合具体实施例对本发明作进一步的说明,但并不因此将本发明限制在所述的实施例范围之中(单位:重量份);
该治疗女性更年期综合征的中药汤剂的制备方法为:按上述重量份称取中药原料,并按原料药与水的重量比1:6的比例加水煎煮,煎煮两遍,头煎:按比例加凉水后,先用大火煮开,在用文火熬煮30分钟,起锅滤汁;二煎:在头煎药渣中再加头煎用量的凉水,再次用大火煮开后,再用文火熬煮30分钟,然后起锅滤汁,将两次煎出的药汁混合,即得治疗女性更年期综合征的中药汤剂成品,将上述中药汤剂成品分装到200 ml的药瓶内,在0-3℃的温度下保存备用,保存期为1个月,服用时将药瓶放入70-80℃的热水中加热15分钟即可服用。
典型病例举例:
1、王某,女,53岁,江陵县马家寨乡人。患者失眠,烦躁半年,近日来自觉一阵阵发热,出汗,二便调,停经一年。2018年4月10日来我门诊求治。查体:舌红,苔少,脉弦数。服用本发明治疗更年期综合征的中药汤剂7天后,失眠烦躁减轻,发热汗出明显好转,于上方再服一周后偶有失眠,余症痊愈,半年后随访未见复发。
2、赵某,女,49岁,毛家港镇新桥村渔场人。患者发热,烦躁年余,近日来自觉手心发热,小便黄,大便稍结,2014年6月因子宫肌瘤行子宫切除术。2018年月3日来我门诊求治。查体:舌质红按,苔少,脉弦涩。服用本发明治疗更年期综合征的中药汤剂7天后,发热烦躁减轻,发热汗出明显好转,于上方再服一周后,悉症尽除,半年后随访未见复发。
Claims (3)
1.一种治疗女性更年期综合征的中药汤剂,其特征在于:它由下述重量份的中药原料制成:
炒枣仁 25~35 茯苓 10~20 川芎 5~15
知母 10~20 丹参 10~20 柴胡 5~15
生地 10~20 炒白芍 2~8 浮小麦 15~25
当归 10~20 桃仁 5~15 红花 5~15
炙远志 10~20 甘草 3~9;
该治疗女性更年期综合征的中药汤剂的制备方法为:按上述重量份称取中药原料,并按原料药与水的重量比1:6的比例加水煎煮,煎煮两遍,头煎:按比例加凉水后,先用大火煮开,在用文火熬煮30分钟,起锅滤汁;二煎:在头煎药渣中再加头煎用量的凉水,再次用大火煮开后,再用文火熬煮30分钟,然后起锅滤汁,将两次煎出的药汁混合,即得治疗女性更年期综合征的中药汤剂成品,将上述中药汤剂成品分装到200 ml的药瓶内,在0-3℃的温度下保存备用,保存期为1个月,服用时将药瓶放入70-80℃的热水中加热15分钟即可服用。
2.根据权利要求1所述的一种治疗女性更年期综合征的中药汤剂,其中各原料的重量配比是:
炒枣仁 28~32 茯苓 13~17 川芎 8~12
知母 12~18 丹参 13~17 柴胡 8~12
生地 12~18 炒白芍 4~6 浮小麦 18~22
当归 12~18 桃仁 8~12 红花 8~12
炙远志 12~18 甘草 5~7。
3.根据权利要求1所述的一种治疗女性更年期综合征的中药汤剂,其中各原料的重量配比是:
炒枣仁 30 茯苓 15 川芎 10
知母 15 丹参 15 柴胡 10
生地 15 炒白芍 5 浮小麦 20
当归 15 桃仁 10 红花 10
炙远志 15 甘草 6。
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CN115779043A (zh) * | 2022-11-11 | 2023-03-14 | 中国中医科学院广安门医院 | 一种治疗女性更年期综合征的中药组合物,制备方法及其应用 |
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