CN108653637A - 一种治疗皮肤病的外用药及其制备方法 - Google Patents
一种治疗皮肤病的外用药及其制备方法 Download PDFInfo
- Publication number
- CN108653637A CN108653637A CN201811009548.7A CN201811009548A CN108653637A CN 108653637 A CN108653637 A CN 108653637A CN 201811009548 A CN201811009548 A CN 201811009548A CN 108653637 A CN108653637 A CN 108653637A
- Authority
- CN
- China
- Prior art keywords
- externally applied
- applied drug
- preparation
- parts
- dermopathic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 64
- 229940079593 drug Drugs 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 20
- 240000000774 Cunila origanoides Species 0.000 claims abstract description 17
- 235000018274 Cunila origanoides Nutrition 0.000 claims abstract description 17
- 235000014866 Dictamnus albus Nutrition 0.000 claims abstract description 17
- 241000717679 Mosla Species 0.000 claims abstract description 16
- 241000519740 Ilex rotunda Species 0.000 claims abstract description 15
- 235000008702 Ilex rotunda Nutrition 0.000 claims abstract description 15
- 241001671204 Stemona Species 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 239000002671 adjuvant Substances 0.000 claims abstract description 8
- 235000003434 Sesamum indicum Nutrition 0.000 claims description 14
- 235000009496 Juglans regia Nutrition 0.000 claims description 13
- 235000020234 walnut Nutrition 0.000 claims description 13
- 240000004922 Vigna radiata Species 0.000 claims description 12
- 235000010721 Vigna radiata var radiata Nutrition 0.000 claims description 12
- 235000011469 Vigna radiata var sublobata Nutrition 0.000 claims description 12
- 239000004576 sand Substances 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 6
- 238000005202 decontamination Methods 0.000 claims description 6
- 230000003588 decontaminative effect Effects 0.000 claims description 6
- 238000004821 distillation Methods 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 244000000231 Sesamum indicum Species 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 244000301850 Cupressus sempervirens Species 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 235000019441 ethanol Nutrition 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 244000296102 Selinum monnieri Species 0.000 claims description 2
- 235000019084 Selinum monnieri Nutrition 0.000 claims description 2
- 240000007049 Juglans regia Species 0.000 claims 4
- 244000013123 dwarf bean Species 0.000 claims 1
- 235000021331 green beans Nutrition 0.000 claims 1
- 238000004321 preservation Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 15
- 241000758789 Juglans Species 0.000 description 9
- 241000207961 Sesamum Species 0.000 description 9
- 208000017520 skin disease Diseases 0.000 description 6
- 208000003251 Pruritus Diseases 0.000 description 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 229910052709 silver Inorganic materials 0.000 description 5
- 239000004332 silver Substances 0.000 description 5
- 231100000331 toxic Toxicity 0.000 description 5
- 230000002588 toxic effect Effects 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 206010033733 Papule Diseases 0.000 description 3
- 206010067482 No adverse event Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000037311 normal skin Effects 0.000 description 2
- 244000144730 Amygdalus persica Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 241000669298 Pseudaulacaspis pentagona Species 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 235000002597 Solanum melongena Nutrition 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000005456 alcohol based solvent Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000002804 anti-anaphylactic effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001114 myogenic effect Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗皮肤病的外用药及其制备方法，它是以白鲜皮、七星剑、苦参、百部、蛇床子铁冬青及辅剂为原料，将中药原料的提取物与中药原料的熬和物混合后，室温密封保存30～100天后获得治疗皮肤病的外用药。本发明产品组合物及制备方法独特，治疗效果显著。
Description
技术领域
本发明涉及一种治疗皮肤病的外用药领域。具体地说是以中草药为原料制备的膏剂，本发明还涉及该外用药的制备方法。
背景技术
皮肤病，是一种常见易发的慢性皮肤疾病，初期表现红色丘疹表面有白色鳞屑，以后丘疹扩大融合，成为大的斑块，鳞屑逐渐增厚，反复发作，迁延不愈。湿热型患者瘙痒难忍，抓挠潮红、糜烂、结节令患者苦不堪言。除身体痛苦之外，还严重影响外表美观，影响患者的生活、就业、婚姻和家庭的和谐。传统治疗皮肤病的中药很多，由于重要原料不同，剂量不同，使得治疗效果也不同。有的存在较大毒副作用，使患者不能忍受甚至出现毒性反应。
发明内容
本发明的目的在于提供一种治疗皮肤病的外用药，该外用药为纯中药组合物。
本发明的另一目的是提供该治疗皮肤病的外用药的制备方法。
本发明的解决方案是基于我国中医理论，皮肤病病因乃素体肌燥肤热，辅为外邪侵袭，导致局部气血运行不畅，或风寒所伤，营卫失调，遇久化燥，肌肤失养，七情所伤，气机受阻，化火炎肤而成，清热解毒凉血是关键，辅以疏通经络，祛风生肌，活血化瘀，滋养皮肤抑制皮屑增长以达彻底根除之目的。本发明中，白鲜皮作为清热解毒药物，经过与一定量的苦参、七星剑、核桃混合后，明显提高白鲜皮清热解毒的功效，再添加百部、蛇床子可有效降低复发率，再添加一些芝麻等辅助剂，进一步修复受损肌肤的功能。按中医理论组方，提取中药的精华，使其发挥促进作用，彻底根治皮肤病。
本发明中药组合物包括白鲜皮、七星剑、苦参、百部、蛇床子、铁冬青及辅剂，具体由以下重量组分的原料制成：白鲜皮100～200份，七星剑100～200份，苦参100～200份，百部100～200份，蛇床子100～200份，铁冬青100～200份，辅剂为300-600份，所述辅剂为芝麻、绿豆、核桃的混合物，且重量比为1～2：1～2：1～2，其中优选重量比为1：1：1。
本发明外用药采用以下制备方法：
(a)中药原料提取物，将上述重量的芝麻、白鲜皮、七星剑、苦参、核桃、百部、蛇床子、绿豆、铁冬青过筛去杂质后置于砂壶中并密封壶口，用柏枝堵住壶嘴，使壶嘴向下且药材不会漏出，在壶内加入足够的溶剂，将原料完全浸泡在溶剂中，加热砂壶并在550～600℃下保温2小时，然后砂壶温度降至300℃保温2小时且从壶嘴得到蒸馏剂，最后祛除蒸馏剂中的溶剂，得到原料提取物；
(b)中药原料熬和物，将(a)中所述重量的芝麻、白鲜皮、七星剑、苦参、核桃、百部、蛇床子、绿豆、铁冬青过筛去杂质后加入容器中，在该容器中加入蒸馏水，蒸馏水和原料的重量比为1～2：1(优选重量比为1：1)，加热至沸腾并保持2小时，滤去残渣并继续加热至沸腾，将药液浓缩一倍冷却后得到中药原料熬和物；
(c)外用药，将步骤(a)所得原料提取物与步骤(b)所得中药原料熬和物混合均匀，制备得到药物混合物，将药物混合物在室温条件下密封保存30～100天(优选密封保存90天)，得到治疗皮肤病的外用药。
所述步骤(a)中所述溶剂优选为乙醇。
本发明使用方法：将制备的外用药涂覆于皮肤患处，用保鲜膜覆盖，每日一次，每次2～10小时。
本发明的中药详细情况如下：
白鲜皮：味苦咸、性寒，具有清热燥湿、祛风止痒、解毒功效。
七星剑：味辛，性微温，具有发汗解暑、利湿角毒之功效。
苦参：味苦，性寒，具有清热燥湿、杀虫、利尿功效。
百部：味甘苦、性微温，具有润肺止咳、杀虫灭虱功效。
蛇床子：味辛苦、性温，具有温肾壮阳、燥湿杀虫、祛风止痒功效。
铁冬青：味苦、性寒，具有清热解毒、利湿止痛功效。
绿豆：味甘，性寒，具有清热解暑、清血利尿、排毒美肤，抗过敏的功能。
芝麻：具有皮肤抗衰老、养血的功效。
核桃：味甘、性温，具有健胃、补血、润肺、养神等功效。
与现有技术相比，本发明的有益技术效果：本发明将中药原料提取物与中药原料熬和物混合均匀后制备成治疗皮肤病的外用药，该外用药无刺激性和毒副作用，可以使药物直达病灶，彻底根治皮肤病，且不易复发。
具体实施方式
实施例1
一种治疗皮肤病的外用药，按下述配比称取原料：白鲜皮100克，七星剑100克，苦参100克，百部100克，蛇床子100克，铁冬青100克，绿豆100克，芝麻100克，核桃100克。
制备方法如下：(a)中药原料提取物，将上述重量的芝麻、白鲜皮、七星剑、苦参、核桃、百部、蛇床子、绿豆、铁冬青过筛去杂质后置于砂壶中并密封壶口，用柏枝堵住壶嘴，使壶嘴向下且药材不会漏出，在壶内加入足够的乙醇溶剂，将原料完全浸泡在乙醇溶剂中，加热砂壶并在550℃下保温2小时，然后砂壶温度降至300℃保温2小时且从壶嘴得到蒸馏剂，最后祛除蒸馏剂中的溶剂，得到原料提取物；
(b)中药原料熬和物，将(a)中所述重量的芝麻、白鲜皮、七星剑、苦参、核桃、百部、蛇床子、绿豆、铁冬青过筛去杂质后加入容器中，在该容器中加入蒸馏水，蒸馏水和原料的重量比为1：1，加热至沸腾并保持2小时，滤去残渣并继续加热至沸腾，将药液浓缩一倍冷却后得到中药原料熬和物；
(c)外用药，将步骤(a)所得原料提取物与步骤(b)所得中药原料熬和物混合均匀，制备得到药物混合物，将药物混合物在室温条件下密封保存90天，得到治疗皮肤病的外用药。
实施例2
按照实施例1的制备方法，改变原料的配比制备外用药，原料的配比如下：
白鲜皮150份，七星剑150份，苦参150份，百部150份，蛇床子150份，铁冬青150份，芝麻150份，核桃150份，绿豆150份。
实施例3
按照实施例1的制备方法，改变原料的配比制备外用药，原料的配比如下：
白鲜皮200份，七星剑200份，苦参200份，百部200份，蛇床子200份，铁冬青200份，核桃200份，芝麻200份，绿豆200份。
临床案例
案例1
许某，男，33岁，汉族，河北定兴县人。患者于十余年突发牛皮癣前后背突发红色丘疹数个，伴脱屑，当时未引起注意，两月后加重，背部、腹部大面积斑块伴脱屑，背部及腹部出现大量抓痕，结茄，久治未愈。
患者应用本药剂治疗，将制备的外用药涂覆于皮肤患处，用保鲜膜覆盖，每日一次，每次4小时。用药一天瘙痒停止，五天后银屑消失，无不良反应及毒副作用，用十天以后皮肤恢复正常，无丘疹无银屑，病变部位可见少量色素沉着，其他与正常皮肤相同，巩固四周停药未复发。
案例2
展某，女，41岁，汉族，河北定州人。患者于十五年前上肢出现几处红色斑丘疹，伴脱屑微痒，就诊于十余家医院均未治愈。使用本药剂前，可见双上肢大面积白色银屑，刮去银屑后可见红色斑丘疹。
使用本配方治疗，将制备的外用药涂覆于皮肤患处，用保鲜膜覆盖，每日一次，每次4小时。第五天银屑消失，显现红色斑丘疹，10天左右皮损消失，病变部位有少量色素沉着，其他与正常皮肤相同，巩固四周停药，未复发。
疗效统计
经过坚持采用上述发明的药物组合物治愈患者183例，年龄10～82岁，其中男性102例女性81例，皮肤病位置为头面部、躯干四肢，均采用本药剂治疗。经过用药1个月后，其中治愈率达98％，无不良反应和毒副作用，愈后者随访均未复发。经上述事实证明，该发明的治疗皮肤病的外用药有非常显著的疗效。
以上所述的实施例仅是对本发明的优选方式进行描述，并非对本发明的范围进行限定，在不脱离本发明精神的基础之下，本领域普通技术人员可以对本发明的技术方案做出的各种修改和改进，均应落入本发明权利要求书确定的保护范围内。
Claims (9)
1.一种治疗皮肤病的外用药，包括白鲜皮、七星剑、苦参、百部、蛇床子铁冬青及辅剂，其特征在于由以下重量组分的原料制成：白鲜皮100～200份，七星剑100～200份，苦参100～200份，百部100～200份，蛇床子100～200份，铁冬青100～200份，辅剂为300-600份，所述辅剂为芝麻、绿豆、核桃的混合物，且重量比为1～2：1～2：1～2。
2.根据权利要求1所述的治疗皮肤病的外用药，其特征在于：所述芝麻、绿豆、核桃的重量比为1：1：1。
3.根据权利要求1或2所述的治疗皮肤病的外用药，其特征在于：外用药为膏剂。
4.一种治疗皮肤病的外用药的制备方法，其特征在于：
(a)中药原料提取物，将上述重量的芝麻、白鲜皮、七星剑、苦参、核桃、百部、蛇床子、绿豆、铁冬青过筛去杂质后置于砂壶中并密封壶口，用柏枝堵住壶嘴，使壶嘴向下且药材不会漏出，在壶内加入足够的溶剂，将原料完全浸泡在溶剂中，加热砂壶并在550～600℃下保温2小时，然后砂壶温度降至300℃保温2小时且从壶嘴得到蒸馏剂，最后祛除蒸馏剂中的溶剂，得到原料提取物；
(b)中药原料熬和物，将(a)中所述重量的芝麻、白鲜皮、七星剑、苦参、核桃、百部、蛇床子、绿豆、铁冬青过筛去杂质后加入容器中，在该容器中加入蒸馏水，蒸馏水和原料的重量比为1～2：1，加热至沸腾并保持2小时，滤去残渣并继续加热至沸腾，将药液浓缩一倍冷却后得到中药原料熬和物；
(c)外用药，将步骤(a)所得原料提取物与步骤(b)所得中药原料熬和物混合均匀，制备得到药物混合物，将药物混合物在室温条件下密封保存30～100天，得到治疗皮肤病的外用药。
5.根据权利要求4所述外用药的制备方法，其特征在于：步骤(a)中所述溶剂为乙醇。
6.根据权利要求4所述外用药的制备方法，其特征在于：步骤(b)中所述蒸馏水与原料的重量比为1：1。
7.根据权利要求4所述外用药的制备方法，其特征在于：步骤(c)中所述的药物混合物在室温下密封保存90天。
8.根据权利要求4所述治疗皮肤病的外用药的制备方法，其特征在于：将制备的外用药涂覆于皮肤患处，用保鲜膜覆盖，每日一次，每次2-10小时。
9.根据权利要求1～3所述外用药于治疗皮肤病的应用。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811009548.7A CN108653637A (zh) | 2018-08-31 | 2018-08-31 | 一种治疗皮肤病的外用药及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811009548.7A CN108653637A (zh) | 2018-08-31 | 2018-08-31 | 一种治疗皮肤病的外用药及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108653637A true CN108653637A (zh) | 2018-10-16 |
Family
ID=63789097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811009548.7A Pending CN108653637A (zh) | 2018-08-31 | 2018-08-31 | 一种治疗皮肤病的外用药及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108653637A (zh) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615982A (zh) * | 2004-09-10 | 2005-05-18 | 张国岭 | 消癣擦剂 |
| CN101502480A (zh) * | 2009-02-19 | 2009-08-12 | 南方李锦记有限公司 | 一种具有抑菌、去屑止痒功效的中草药组合物 |
| CN101569729A (zh) * | 2009-06-12 | 2009-11-04 | 贾晋科 | 一种治疗手、足癣的外用药物 |
| CN105267359A (zh) * | 2015-10-24 | 2016-01-27 | 四川聚豪生物科技有限公司 | 一种治疗阴囊湿疹的外用酊剂药物及其制备方法 |
| CN106310066A (zh) * | 2016-10-14 | 2017-01-11 | 亳州市庆聚药业销售有限公司 | 一种治疗牛皮癣的外用中药 |
-
2018
- 2018-08-31 CN CN201811009548.7A patent/CN108653637A/zh active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615982A (zh) * | 2004-09-10 | 2005-05-18 | 张国岭 | 消癣擦剂 |
| CN101502480A (zh) * | 2009-02-19 | 2009-08-12 | 南方李锦记有限公司 | 一种具有抑菌、去屑止痒功效的中草药组合物 |
| CN101569729A (zh) * | 2009-06-12 | 2009-11-04 | 贾晋科 | 一种治疗手、足癣的外用药物 |
| CN105267359A (zh) * | 2015-10-24 | 2016-01-27 | 四川聚豪生物科技有限公司 | 一种治疗阴囊湿疹的外用酊剂药物及其制备方法 |
| CN106310066A (zh) * | 2016-10-14 | 2017-01-11 | 亳州市庆聚药业销售有限公司 | 一种治疗牛皮癣的外用中药 |
Non-Patent Citations (3)
| Title |
|---|
| 徐培焜: "复方百部洗剂治疗手足癣与湿疹95例疗效观察", 《新中医》 * |
| 李晓为: "中药克癣丸治疗银屑病1 046例临床分析", 《山西医药杂志》 * |
| 韩金梅: "自拟中药洗剂治疗鹅掌风", 《中医杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104983977A (zh) | 一种治疗跌打损伤的外用药及其制备方法 | |
| CN103251914A (zh) | 治疗风湿骨病的药物 | |
| CN105012902A (zh) | 一种治疗跌打损伤的药酒及其制备方法 | |
| CN104873446A (zh) | 一种含肉桂油的牙膏 | |
| CN107582720A (zh) | 一种治疗风湿痹痛的中药组合物及其制备方法 | |
| CN108371674A (zh) | 一种用于治疗寻常疣的药膏及其制备方法 | |
| CN104547747A (zh) | 一种快速见效的治疗风寒湿痹药酒及其应用 | |
| CN108653637A (zh) | 一种治疗皮肤病的外用药及其制备方法 | |
| CN104984313B (zh) | 一种治疗冻疮的中药药酒 | |
| CN103977367A (zh) | 一种治疗气滞癖血型褥疮的中药及制备方法 | |
| CN102397470A (zh) | 养颜祛斑膏及其制法 | |
| CN105920130A (zh) | 治疗足跟痛的中药制备方法及其外用膏剂 | |
| CN105616653A (zh) | 一种治疗痱子的中药组合物 | |
| CN111658711A (zh) | 一种治疗烧烫伤的中药配方 | |
| CN110538272A (zh) | 一种治疗软组织损伤关节肿痛的消肿通络散及其制备方法 | |
| CN107019788A (zh) | 一种治疗脚气的中药组合物及其制备方法 | |
| CN106853240A (zh) | 一种可有效治疗骨病的外用汤剂药物及其制备方法 | |
| CN106728060A (zh) | 一种治疗风湿病的外用膏药及其制备方法 | |
| CN106074813A (zh) | 一种治疗足跟痛的中药熏洗浸泡剂及其制备方法 | |
| CN104257931A (zh) | 骨科用跌打损伤外敷贴剂及制备方法 | |
| CN104524454A (zh) | 一种松筋藤镇痛酊 | |
| CN104173984A (zh) | 一种祛斑美白内服中药 | |
| CN110859880A (zh) | 一种多功效外用药酒的制备方法 | |
| CN114129669A (zh) | 一种用于治疗风湿的巴布贴剂的制备方法及其巴布贴剂 | |
| CN103877557A (zh) | 一种治疗甲癣的中药药膏及制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181016 |
|
| RJ01 | Rejection of invention patent application after publication |