CN108653605A - A kind of Chinese medicine composition treating and preventing dog diabetes - Google Patents
A kind of Chinese medicine composition treating and preventing dog diabetes Download PDFInfo
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Abstract
The present invention provides a kind of Chinese medicine composition treating and preventing dog diabetes, belong to veterinary drug technical field, using the coptis, balsam pear, Radix Codonopsis, radix scrophulariae, Radix Astragali, Chinese yam, Fructus Corni, Radix Ophiopogonis, the root bark of Chinese wolf-berry, root of Chinese trichosanthes, the fruit of Chinese wolfberry, the root bark of white mulberry, pueraria lobata, corn stigma as raw material.The Chinese medicine composition of the present invention can effectively reduce the blood-sugar content and glucose in urine content of disease dog, can effectively prevent dog diabetes.
Description
Technical field
The present invention relates to veterinary drug technical field, especially a kind of Chinese medicine composition treating and preventing dog diabetes.
Background technology
Diabetes are metabolic disorders complicated caused by many factors, it is characterized in that insulin is opposite or absolutely reduces feelings
Under condition or insulin is impaired, so as to cause to food or obtaining carbohydrate from gluconeogenesis and not tolerating, makes blood
Sugared concentration increases, and generates hyperglycemia.Generally in clinic, diabetes are mainly divided into 4 big types, i.e. Type I diabetes, II type
Diabetes, other specific type diabetes and gestational diabetes mellitus, secondary diabetes.
With the improvement of living standards, Canidae diabetes take place frequently.Its cause of disease is still not clear, is the compound work of many factors
Result.Heredity, infection, drug, obesity, pancreatitis, immune mediating pancreatitis etc. are the diseases for thinking to cause diabetes
Cause.The diabetes of nearly all dog are all insulin-dependent diabetes mellitus, i.e. Type I diabetes (insulin-dependent
Diabetes mellitus, IDDM), this patients with type Ⅰ DM is characterized in hypoinsulinemia.Most dogs occur when diabetes to be 4-
14 years old, 7-9 Sui was occurred frequently, and female incidence is 2 times of male.The epidemiology investigation that Guptill etc. is done for 1999 shows Australia
Dog, Yorkshire Terrier, Xue Narui, than bear dog, Poodle Sa Moye dogs and Lhasa Apso has diabetes easily to send out tendency at fox-terrier.Sugar
The common symptom of urine disease shows as more drinks, diuresis, more foods and weight loss.Only it is more to cause just to will appear when glycosuria mostly drink for hyperglycemia
Urine, iatrogenic hypoglycemia, cataract, lower urinary tract bacterium infection, pancreatitis, ketoacidemia, liver lipidosis syndrome etc.
It is common complication.
It is preventing dog diabetes in the prior art, is there is the scheme puted prevention first, be mainly added in daily grain
Traditional Chinese medicine for decreasing blood sugar, if patent CN201711218321.9 is using grass carp, lotus-seed-heart powder, matrimony vine, multi-vitamins, hawthorn, whole wheat
Powder, olive oil, spirulina and salt formula dog ma is made, as patent CN201710194655.0 using lens, navy bean,
Mushroom, amaranthus caudatus, Phytolacca acinosa, Schima superba, Solanum nigrum, indigo fruit, Panax major, mixed enzyme, adds made of wine yeast rooted celery
Agent also has the scheme based on treatment, mainly carries out injection treatment with insulin at present, also has and is treated using Chinese medicine, such as patent
CN201710280506.6 using Radix Astragali, radix pseudostellariae, sealwort, Chinese yam, Radix Rehmanniae, pueraria lobata, Schisandra chinensis, Radix Salviae Miltiorrhizae, the fruit of Chinese wolfberry, Radix Angelicae Sinensis and
The Chinese medicine preparation of root of Chinese trichosanthes.But the therapeutic effect of the prior art is not ideal enough.
Invention content
In order to solve the above technical problem, the present invention provides it is a kind of treat and prevent dog diabetes Chinese medicine composition,
Specifically include following scheme：
The Chinese medicine composition of dog diabetes is treated and prevented, material composition is 20-40 parts of the coptis, balsam pear 5- in parts by weight
30 parts, 3-14 parts of Radix Codonopsis, 1-7 parts of radix scrophulariae, 10-28 parts of Radix Astragali, 10-25 parts of Chinese yam, 7-18 parts of Fructus Corni, Radix Ophiopogonis 9-34 part,
10-25 parts of bone skin, 12-28 parts of root of Chinese trichosanthes, 5-17 parts of the fruit of Chinese wolfberry, 3-12 parts of the root bark of white mulberry, 5-20 parts of pueraria lobata, 2-11 parts of corn stigma.
It is preferred that the material composition is 22-38 parts of the coptis, 7-28 parts of balsam pear, 4-11 parts of Radix Codonopsis, radix scrophulariae in parts by weight
2-6 parts, 8-20 parts of Radix Astragali, 12-20 parts of Chinese yam, 10-18 parts of Fructus Corni, Radix Ophiopogonis 15-30 part, 10-20 parts of the root bark of Chinese wolf-berry, root of Chinese trichosanthes
18-28 parts, 5-10 parts of the fruit of Chinese wolfberry, 3-9 parts of the root bark of white mulberry, 11-20 parts of pueraria lobata, 8-11 parts of corn stigma.
It is preferred that the material composition is 27 parts of the coptis, 16 parts of balsam pear, 9 parts of Radix Codonopsis, 5 parts of radix scrophulariae, Radix Astragali in parts by weight
14 parts, 17 parts of Chinese yam, 14 parts of Fructus Corni, 22 parts of Radix Ophiopogonis, 14 parts of the root bark of Chinese wolf-berry, 25 parts of root of Chinese trichosanthes, 7 parts of the fruit of Chinese wolfberry, 6 parts of the root bark of white mulberry,
17 parts of pueraria lobata, 9 parts of corn stigma.
It is preferred that the Chinese medicine composition is prepared into pulvis, decoction or paste.
It is preferred that the pulvis, production method are：
1) Radix Codonopsis, radix scrophulariae, the root bark of white mulberry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above ethyl alcohol of weight are added in mixing, and heat is returned
2h or more, filtering are flowed, filter residue adds the alcohol heat reflux 2h of 1 times of weight or more, and merging filtrate is concentrated into phase at 50-60 DEG C
It is spare to the paste A that density is 1.1-1.2；
2) coptis, Radix Astragali, the root bark of Chinese wolf-berry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above water of weight, heat reflux is added in mixing
2h or more, filtering, filter residue add the hydro-thermal reflux 2h of 1 times of weight or more, and merging filtrate is concentrated into relatively close at 50-60 DEG C
Degree is the paste B of 1.1-1.2, spare；
3) Chinese yam, Fructus Corni, Radix Ophiopogonis, the fruit of Chinese wolfberry, pueraria lobata are taken respectively, is crushed, and mixing is added the water of 1 times of weight or more, boils
5-15min is boiled, the paste C for being concentrated into that relative density at 50-60 DEG C is 1.2-1.3 is spare；
4) by paste A, B, C mix, spray drying, be added root of Chinese trichosanthes and crushing corn stigma, stir evenly to get.
It is preferred that the decoction, production method are：
1) Radix Codonopsis, radix scrophulariae, the root bark of white mulberry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above ethyl alcohol of weight are added in mixing, and heat is returned
2h or more, filtering are flowed, filter residue adds the alcohol heat reflux 2h of 1 times of weight or more, and merging filtrate is concentrated into phase at 50-60 DEG C
It is spare to the paste A that density is 1.1-1.2；
2) coptis, Radix Astragali, the root bark of Chinese wolf-berry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above water of weight, heat reflux is added in mixing
2h or more, filtering, filter residue add the hydro-thermal reflux 2h of 1 times of weight or more, and merging filtrate obtains filtrate B, spare；
3) Chinese yam, Fructus Corni, Radix Ophiopogonis, the fruit of Chinese wolfberry, pueraria lobata are taken respectively, is crushed, and mixing is added the water of 1 times of weight or more, boils
5-15min is boiled, liquid object C is obtained, it is spare；
4) paste A, filtrate B, liquids C are mixed, the corn stigma of root of Chinese trichosanthes and crushing is added, stirs evenly, made
At decoction.
It is preferred that the paste, including following preparation process：
1) Radix Codonopsis, radix scrophulariae, the root bark of white mulberry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above ethyl alcohol of weight are added in mixing, and heat is returned
2h or more, filtering are flowed, filter residue adds the alcohol heat reflux 2h of 1 times of weight or more, and merging filtrate is concentrated into phase at 50-60 DEG C
It is spare to the paste A that density is 1.1-1.2；
2) coptis, Radix Astragali, the root bark of Chinese wolf-berry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above water of weight, heat reflux is added in mixing
2h or more, filtering, filter residue add the hydro-thermal reflux 2h of 1 times of weight or more, and merging filtrate is concentrated into relatively close at 50-60 DEG C
Degree is the paste B of 1.1-1.2, spare；
3) Chinese yam, Fructus Corni, Radix Ophiopogonis, the fruit of Chinese wolfberry, pueraria lobata are taken respectively, is crushed, and mixing is added the water of 1 times of weight or more, boils
5-15min is boiled, the paste C for being concentrated into that relative density at 50-60 DEG C is 1.2-1.3 is spare；
4) paste A, paste B, paste C are mixed, root of Chinese trichosanthes and corn stigma is added, stirs evenly to get paste.
In the present invention, the coptis：Alias：Taste connects, river connects, Rhizoma Coptidis；Function with cure mainly：Heat-clearing and damp-drying drug, purging intense heat and detonicating.For
Damp and hot feeling of fullness, vomiting acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache disappear
Yearningly, carbuncle swells furunculosis；Eczema, wet sore are controlled outside, duct is suppurated.It is burning hot that prepared RHIZOMA COPTIDIS with vino is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice is clear
Stomach anti-vomiting.It is mutually tied for fever and chills, damp and hot middle resistance, feeling of fullness vomiting.The easypro liver anti-vomiting of cornel coptis.For liver-stomach disharmony, vomit
Spit acid regurgitation.
Balsam pear：Alias：Bright and beautiful lichee, leprosy grape, red Miss, balsam pear, balsam pear, red sheep.Major function：Heat-relieving；It is bright
Mesh；Removing toxic substances.Main hot summer weather polydipsia；It quenches one's thirst；Cute conjunctivitis pain；Dysentery；Sore and toxic.
Radix Codonopsis：Alias：Partisan joins, platform Radix Codonopsis, kurarinone.Function with cure mainly：Tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung.For spleen and lung void
It is weak, shortness of breath and palpitation, anorexia and loose stool, virtual asthma cough, Heat Diabetes.
Radix scrophulariae：Alias：Radix scrophulariae, black ginseng, black radix scrophulariae, Zhejiang radix scrophulariae.Function with cure mainly：Cool blood enriching yin, purging intense heat and detonicating.For heat
Sick impairment of yin, the deep red polydipsia of tongue, febrile virulent maculae, Tianjin hinder constipation, hectic fever due to yin labor is coughed, hot eyes, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
Radix Astragali：Alias：Arrow stilbene, hundred, the prince's descendants, bright and beautiful stilbene.Function with cure mainly：Invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, sore
Myogenic.For treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, qi deficiency edema, ulcer
Hardly possible is burst, burst for a long time and does not holds back, flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes；Chronic rephrilis protinuria, diabetes.
Chinese yam：Alias：Sweet potato, Chinese yam rhizome, sweet potato.Function with cure mainly：Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying.For
Spleen eating less, endless diarrhea, the deficiency syndrome of the lung are breathed with cough, emission due to the kidney deficiency, and under band, frequent micturition, abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For
Spleen eating less, diarrhea loose stool, leukorrhea.
Fructus Corni：Alias：Dogwood fruit.Function with cure mainly：It tonifies the liver and kidney, restrains astringent method.
Radix Ophiopogonis：This product is the drying of liliaceous plant Radix Ophiopogonis Ophiopogon japonicus (Thunb.) Ker-Gawl.
Root tuber.Function with cure mainly：Nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.For dryness of the lung dry cough.Tuberculosis cough, injury thirst, vexed insomnia are interior
Heat is quenched one's thirst, dry constipation of intestines；Pharyngeal diphtheria.
The root bark of Chinese wolf-berry：Alias：Qi root, save, dog milk root, the red moon pendant root, boxthorn root, lycii radicis,cortex.Function with cure mainly：It is cool
Blood is except steaming, clearing lung-heat fall fire.For deficiency of Yin hectic fever, hectic fever due to yin night sweat, cough with lung heat, spitting of blood, bleeding from five sense organs or subcutaneous tissue, Heat Diabetes.
Root of Chinese trichosanthes：Alias：Trichosanthes fruit root, beach wormwood root, baiyao, day melon powder, timely snow.Function with cure mainly：Clearing heat and promoting fluid, detumescence row
Purulence.For pyreticosis polydipsia, lung-heat type cough, Heat Diabetes, sore swollen toxin.
The fruit of Chinese wolfberry：Alias：FRUCTUS LYCII BARBARI, white thorn, mountain matrimony vine, white lump needle.Major function：It is nourishing liver and kidney, benefiting shrewd head.For
Consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus, Heat Diabetes, blood deficiency chlorosis, blurred vision.
The root bark of white mulberry：Alias：Cortex Mori, mulberry skin, mulberry root skin, Bai Sangpi.Function with cure mainly：Removing heat from lung and relieving asthma, inducing diuresis for removing edema.
For dyspnea and cough due to lung-heat, oedema turgor oliguria, appearance skin edema.
Pueraria lobata：Alias：Sweet tea Pueraria lobota, Pachyrhizua angulatus, dry Pueraria lobota, kudzu.Function with cure mainly：Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid, promoting eruption, Shengyang Zhixie.
It is thirsty for fever caused by exogenous pathogens headache, the strong pain of item, it quenches one's thirst, measles without adequate eruption, hot dysentery, diarrhea；Hypertension neck pain.
Corn stigma：Alias：Ear of maize hair, maize palpus.Function with cure mainly：Diuresis detumescence, removing dampness through diuresis and removing jaundice is hypoglycemic, hemostasis.
For scanty drak urine, leaching drip pain, jaundice, diabetes, gingiva bleeding gingival hemorrhage, purpura haemorrhagica, high blood pressure.
The beneficial effects of the present invention are：The Chinese medicine preparation of the present invention can effectively reduce the blood-sugar content of disease dog and glucose in urine contains
Amount, can effectively prevent dog diabetes.
Specific implementation mode
Be described further below technical scheme of the present invention, but claimed range be not limited to it is described.
Embodiment one
A kind of Chinese medicine powder treating and preventing dog diabetes, material composition are coptis 20g, balsam pear 5g, party by weight
Join 3g, radix scrophulariae 1g, Radix Astragali 10g, Chinese yam 10g, Fructus Corni 7g, Radix Ophiopogonis 9g, root bark of Chinese wolf-berry 10g, root of Chinese trichosanthes 12g, the fruit of Chinese wolfberry 5g, Sang Bai
Skin 3g, pueraria lobata 5g, corn stigma 2g.
Production method is：
1) Radix Codonopsis, radix scrophulariae, the root bark of white mulberry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above ethyl alcohol of weight are added in mixing, and heat is returned
2h or more, filtering are flowed, filter residue adds the alcohol heat reflux 2h of 1 times of weight or more, and merging filtrate is concentrated into phase at 50-60 DEG C
It is spare to the paste A that density is 1.1-1.2；
2) coptis, Radix Astragali, the root bark of Chinese wolf-berry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above water of weight, heat reflux is added in mixing
2h or more, filtering, filter residue add the hydro-thermal reflux 2h of 1 times of weight or more, and merging filtrate is concentrated into relatively close at 50-60 DEG C
Degree is the paste B of 1.1-1.2, spare；
3) Chinese yam, Fructus Corni, Radix Ophiopogonis, the fruit of Chinese wolfberry, pueraria lobata are taken respectively, is crushed, and mixing is added the water of 1 times of weight or more, boils
5-15min is boiled, the paste C for being concentrated into that relative density at 50-60 DEG C is 1.2-1.3 is spare；
4) by paste A, B, C mix, spray drying, be added root of Chinese trichosanthes and crushing corn stigma, stir evenly to get.
Embodiment two
A kind of Chinese medicine powder treating and preventing dog diabetes, material composition are coptis 40g, balsam pear 30g, party by weight
Join 14g, radix scrophulariae 7g, Radix Astragali 28g, Chinese yam 25g, Fructus Corni 18g, Radix Ophiopogonis 34g, root bark of Chinese wolf-berry 25g, root of Chinese trichosanthes 28g, fruit of Chinese wolfberry 17g,
Root bark of white mulberry 12g, pueraria lobata 20g, corn stigma 11g.
After directly mixing, it is ground into powder, addition is fed in dog feed, and 0.1kg pulvis is added according to every kg feeds.
Embodiment three
A kind of traditional Chinese herbal decoction treating and preventing dog diabetes, material composition are coptis 22g, balsam pear 7g, party by weight
Join 4g, radix scrophulariae 2g, Radix Astragali 8g, Chinese yam 12g, Fructus Corni 10g, Radix Ophiopogonis 15g, root bark of Chinese wolf-berry 10g, root of Chinese trichosanthes 18g, fruit of Chinese wolfberry 5g, mulberry
White skin 3g, pueraria lobata 11g, corn stigma 8g.
Its production method is：
1) Radix Codonopsis, radix scrophulariae, the root bark of white mulberry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above ethyl alcohol of weight are added in mixing, and heat is returned
2h or more, filtering are flowed, filter residue adds the alcohol heat reflux 2h of 1 times of weight or more, and merging filtrate is concentrated into phase at 50-60 DEG C
It is spare to the paste A that density is 1.1-1.2；
2) coptis, Radix Astragali, the root bark of Chinese wolf-berry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above water of weight, heat reflux is added in mixing
2h or more, filtering, filter residue add the hydro-thermal reflux 2h of 1 times of weight or more, and merging filtrate obtains filtrate B, spare；
3) Chinese yam, Fructus Corni, Radix Ophiopogonis, the fruit of Chinese wolfberry, pueraria lobata are taken respectively, is crushed, and mixing is added the water of 1 times of weight or more, boils
5-15min is boiled, liquid object C is obtained, it is spare；
4) paste A, filtrate B, liquids C are mixed, the corn stigma of root of Chinese trichosanthes and crushing is added, stirs evenly, made
At decoction.
Example IV
A kind of traditional Chinese herbal decoction treating and preventing dog diabetes, material composition are coptis 38g, balsam pear 28g, party by weight
Join 11g, radix scrophulariae 6g, Radix Astragali 20g, Chinese yam 20g, Fructus Corni 18g, Radix Ophiopogonis 30g, root bark of Chinese wolf-berry 20g, root of Chinese trichosanthes 28g, fruit of Chinese wolfberry 10g,
Root bark of white mulberry 9g, pueraria lobata 20g, corn stigma 11g.
After directly mixing, the water of 10 times of weight of mixture quality is added, heating, which boils, decocts 5-15min, filters, obtains
Decoction.Or decoction is concentrated into paste making agent.
Embodiment five
A kind of Chinese medicinal ointment treating and preventing dog diabetes, material composition are coptis 27g, balsam pear 16g, party by weight
Join 9g, radix scrophulariae 5g, Radix Astragali 14g, Chinese yam 17g, Fructus Corni 14g, Radix Ophiopogonis 22g, root bark of Chinese wolf-berry 14g, root of Chinese trichosanthes 25g, fruit of Chinese wolfberry 7g, mulberry
White skin 6g, pueraria lobata 17g, corn stigma 9g.
Including following preparation process：
1) Radix Codonopsis, radix scrophulariae, the root bark of white mulberry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above ethyl alcohol of weight are added in mixing, and heat is returned
2h or more, filtering are flowed, filter residue adds the alcohol heat reflux 2h of 1 times of weight or more, and merging filtrate is concentrated into phase at 50-60 DEG C
It is spare to the paste A that density is 1.1-1.2；
2) coptis, Radix Astragali, the root bark of Chinese wolf-berry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above water of weight, heat reflux is added in mixing
2h or more, filtering, filter residue add the hydro-thermal reflux 2h of 1 times of weight or more, and merging filtrate is concentrated into relatively close at 50-60 DEG C
Degree is the paste B of 1.1-1.2, spare；
3) Chinese yam, Fructus Corni, Radix Ophiopogonis, the fruit of Chinese wolfberry, pueraria lobata are taken respectively, is crushed, and mixing is added the water of 1 times of weight or more, boils
5-15min is boiled, the paste C for being concentrated into that relative density at 50-60 DEG C is 1.2-1.3 is spare；
4) paste A, paste B, paste C are mixed, root of Chinese trichosanthes and corn stigma is added, stirs evenly to get paste.
In order to illustrate the technique effect of the present invention, this researcher has carried out following experiment：
1, sick dog is chosen
5 Sa Moye adult dogs for suffering from glucose in urine symptom are selected, weight is in 20kg or more, respectively marked as A1-A5.
2, material
Shearing shears, spectrophotometer, colorimetric cylinder, tourniquet, urine collection bag, water-bath, test tube, disposable syringe, suction pipe,
Beaker, centrifuge, ortho-aminotoluene reagent, Glucose standards storage liquid (10mg/ml), Glucose standards application liquid (1mg/ml),
0.25% benzyl alcohol solution, cotton ball soaked in alcohol, Benedict's reagent, vaseline oil, medical distilled water, phenformin, insulin, embodiment one
The pulvis of making, the decoction that embodiment three makes, the paste that embodiment five makes.
2.1 detect the blood-sugar content and glucose in urine content of Sa Moye first.
2.1.1 blood sugar test
Blood specimen collection method：Dog is drawn blood in the inner forearm cutaneous vein vena cutanea of dog on an empty stomach in the morning, extracts 2ml whole bloods.
The processing of blood：Centrifuge 10-12 minutes first in centrifuge after acquisition blood sample, then by test tube it is tilting equipped with
Accelerate the precipitation of serum in 25-37 DEG C of warm water beaker, and detaches.
Blood sugar detecting method：
1 ortho-aminotoluene method of table measures the reagent combination of blood glucose
| It is added without other with pipe | Measure pipe | Standard pipe | Blank tube |
| Serum or blood plasma | 0.1 | —— | —— |
| Glucose standards application liquid | —— | 0.1 | —— |
| Distilled water | —— | —— | 0.1 |
| Ortho-aminotoluene reagent | 5.0 | 5.0 | 5.0 |
By in a test tube reagent and sample mix, be placed in boiling water and boil 8min, immerse ice water in 3-5min,
30min content 620nm wavelength or red worry tabula rasa carry out colorimetric.Read each pipe optical density number.
The testing result of blood glucose is as follows：
Table 2：Blood glucose test results
2.1.2 glucose in urine detects
Urine capture：The 2-3h after sick dog adopts feeding, the external genital of disease dog is fixed on urine collection bag, and to pick up urine about 5ml standby
With.
Urine preserves：0.5-1ml ratios addition toluene is added in urine is per 100ml to be preserved.
Detection method：It takes Benedict's reagent 5ml in test tube, is heated to boiling, reagent becomes more blue and transparent, then
It is added and is detected urine 0.5ml, continue ebuillition of heated 1-2min, be placed on clean blank sheet of paper after the cooling 5min of standing and judge result.
3 Benedict's reagent of table examines the criterion table of glucose in urine
| Reagent reacts | Glucose content (about g%) | Result judgement |
| Reagent is still in limpid blue after boiling cooling | Nothing | - |
| There is a small amount of green precipitate after boiling cooling | 0.1-0.5 | + |
| Yellow-green precipitate is shown after boiling one minute | 0.5-1.4 | ++ |
| Displaing yellow precipitates after boiling 10-15 seconds | 1.4-2.0 | +++ |
| Yellow or red-brown precipitation are seen in boiling | 2 or more | ++++ |
The testing result of glucose in urine detection：
Table 4：The testing result of glucose in urine
| Group | Result judgement |
| A1 | +++ |
| A2 | ++++ |
| A3 | ++++ |
| A4 | +++ |
| A5 | +++ |
Then phenformin (feeding volume 20g) is fed to the dog marked as A1, to marked as (the injection of A2 dogs insulin injection
Amount is 4IU), granular preparation (feeding volume 20g) is fed to the dog marked as A3, oral decoction is fed to the dog marked as A4
(feeding volume 30g), the dog marked as A5 feed pill (feeding volume 20g), feed or inject daily once, every 20 days
Detect a blood-sugar content and glucose in urine content.
Table 5：Blood-sugar content after treatment
Table 6：Glucose in urine content after treatment
| Group | First time glucose in urine content | Second of glucose in urine content | Third time glucose in urine content |
| A1 | +++ | ++ | ++ |
| A2 | +++ | ++ | + |
| A3 | +++ | + | - |
| A4 | ++ | + | - |
| A5 | ++ | + | - |
It is compared, can be obtained by table 5, table 6 and table 2, table 3, Chinese medicine preparation provided by the invention is in feeding initial stage, drop
The blood glucose and glucose in urine effect of low dog are similar with phenformin, insulin injection, in the middle and later periods of feeding, Chinese medicine system provided by the invention
Agent is with obvious effects better than phenformin, insulin injection, illustrates that Chinese medicine preparation provided by the invention can obviously reduce Sa Moye dogs
Blood glucose can be effectively prevented and treated Sa Moye dog diabetes.
Claims (7)
1. a kind of Chinese medicine composition treating and preventing dog diabetes, which is characterized in that material composition is the coptis in parts by weight
20-40 parts, 5-30 parts of balsam pear, 3-14 parts of Radix Codonopsis, 1-7 parts of radix scrophulariae, 10-28 parts of Radix Astragali, 10-25 parts of Chinese yam, 7-18 parts of Fructus Corni,
Radix Ophiopogonis 9-34 part, 10-25 parts of the root bark of Chinese wolf-berry, 12-28 parts of root of Chinese trichosanthes, 5-17 parts of the fruit of Chinese wolfberry, 3-12 parts of the root bark of white mulberry, 5-20 parts of pueraria lobata,
2-11 parts of corn stigma.
2. treating and preventing the Chinese medicine composition of dog diabetes as described in claim 1, it is characterised in that：The raw material at
Divide is 22-38 parts of the coptis, 7-28 parts of balsam pear, 4-11 parts of Radix Codonopsis, 2-6 parts of radix scrophulariae, 8-20 parts of Radix Astragali, Chinese yam 12- in parts by weight
20 parts, 10-18 parts of Fructus Corni, Radix Ophiopogonis 15-30 part, 10-20 parts of the root bark of Chinese wolf-berry, 18-28 parts of root of Chinese trichosanthes, 5-10 parts of the fruit of Chinese wolfberry, Sang Bai
3-9 parts of skin, 11-20 parts of pueraria lobata, 8-11 parts of corn stigma.
3. treating and preventing the Chinese medicine composition of dog diabetes as described in claim 1, it is characterised in that：The raw material at
Be point in parts by weight 27 parts of the coptis, 16 parts of balsam pear, 9 parts of Radix Codonopsis, 5 parts of radix scrophulariae, 14 parts of Radix Astragali, 17 parts of Chinese yam, 14 parts of Fructus Corni,
22 parts of Radix Ophiopogonis, 14 parts of the root bark of Chinese wolf-berry, 25 parts of root of Chinese trichosanthes, 7 parts of the fruit of Chinese wolfberry, 6 parts of the root bark of white mulberry, 17 parts of pueraria lobata, 9 parts of corn stigma.
4. the Chinese medicine composition of the treatment and prevention dog diabetes as described in claim 1-3, it is characterised in that：The Chinese medicine
Composition is prepared into pulvis, decoction or paste.
5. treating and preventing the Chinese medicine composition of dog diabetes as claimed in claim 4, it is characterised in that：The pulvis,
Its production method is：
1) Radix Codonopsis, radix scrophulariae, the root bark of white mulberry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above ethyl alcohol of weight, heat reflux 2h is added in mixing
More than, filtering, filter residue adds the alcohol heat reflux 2h of 1 times of weight or more, and merging filtrate is concentrated into relatively close at 50-60 DEG C
Degree is the paste A of 1.1-1.2, spare；
2) coptis, Radix Astragali, the root bark of Chinese wolf-berry are taken respectively, crush, cross 20 mesh sieve, mixing, be added 10 times of above water of weight, heat reflux 2h with
On, filtering, filter residue adds the hydro-thermal reflux 2h of 1 times of weight or more, and merging filtrate, being concentrated into relative density at 50-60 DEG C is
1.1-1.2 paste B, it is spare；
3) Chinese yam, Fructus Corni, Radix Ophiopogonis, the fruit of Chinese wolfberry, pueraria lobata are taken respectively, is crushed, and mixing is added the water of 1 times of weight or more, boils 5-
15min, the paste C for being concentrated into that relative density at 50-60 DEG C is 1.2-1.3, it is spare；
4) by paste A, B, C mix, spray drying, be added root of Chinese trichosanthes and crushing corn stigma, stir evenly to get.
6. treating and preventing the Chinese medicine composition of dog diabetes as claimed in claim 4, it is characterised in that：The decoction,
Its production method is：
1) Radix Codonopsis, radix scrophulariae, the root bark of white mulberry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above ethyl alcohol of weight, heat reflux 2h is added in mixing
More than, filtering, filter residue adds the alcohol heat reflux 2h of 1 times of weight or more, and merging filtrate is concentrated into relatively close at 50-60 DEG C
Degree is the paste A of 1.1-1.2, spare；
2) coptis, Radix Astragali, the root bark of Chinese wolf-berry are taken respectively, crush, cross 20 mesh sieve, mixing, be added 10 times of above water of weight, heat reflux 2h with
On, filtering, filter residue adds the hydro-thermal reflux 2h of 1 times of weight or more, and merging filtrate obtains filtrate B, spare；
3) Chinese yam, Fructus Corni, Radix Ophiopogonis, the fruit of Chinese wolfberry, pueraria lobata are taken respectively, is crushed, and mixing is added the water of 1 times of weight or more, boils 5-
15min obtains liquid object C, spare；
4) paste A, filtrate B, liquids C are mixed, the corn stigma of root of Chinese trichosanthes and crushing is added, stirs evenly, soup is made
Agent.
7. treating and preventing the Chinese medicine composition of dog diabetes as claimed in claim 4, it is characterised in that：The paste,
Including following preparation process：
1) Radix Codonopsis, radix scrophulariae, the root bark of white mulberry are taken respectively, is crushed, 20 mesh sieve is crossed, and 10 times of above ethyl alcohol of weight, heat reflux 2h is added in mixing
More than, filtering, filter residue adds the alcohol heat reflux 2h of 1 times of weight or more, and merging filtrate is concentrated into relatively close at 50-60 DEG C
Degree is the paste A of 1.1-1.2, spare；
2) coptis, Radix Astragali, the root bark of Chinese wolf-berry are taken respectively, crush, cross 20 mesh sieve, mixing, be added 10 times of above water of weight, heat reflux 2h with
On, filtering, filter residue adds the hydro-thermal reflux 2h of 1 times of weight or more, and merging filtrate, being concentrated into relative density at 50-60 DEG C is
1.1-1.2 paste B, it is spare；
3) Chinese yam, Fructus Corni, Radix Ophiopogonis, the fruit of Chinese wolfberry, pueraria lobata are taken respectively, is crushed, and mixing is added the water of 1 times of weight or more, boils 5-
15min, the paste C for being concentrated into that relative density at 50-60 DEG C is 1.2-1.3, it is spare；
4) paste A, paste B, paste C are mixed, root of Chinese trichosanthes and corn stigma is added, stirs evenly to get paste.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274429A (en) * | 2011-07-28 | 2011-12-14 | 连建亭 | Chinese medicinal composition for treating diabetes |
| CN103404638A (en) * | 2013-07-12 | 2013-11-27 | 苏州市天灵中药饮片有限公司 | Sugar-reducing tea leaves |
| CN106581492A (en) * | 2016-12-30 | 2017-04-26 | 孝感华越机电科技有限公司 | Traditional Chinese medicine for treatment of diabetes |
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2018
- 2018-07-03 CN CN201810715878.1A patent/CN108653605A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274429A (en) * | 2011-07-28 | 2011-12-14 | 连建亭 | Chinese medicinal composition for treating diabetes |
| CN103404638A (en) * | 2013-07-12 | 2013-11-27 | 苏州市天灵中药饮片有限公司 | Sugar-reducing tea leaves |
| CN106581492A (en) * | 2016-12-30 | 2017-04-26 | 孝感华越机电科技有限公司 | Traditional Chinese medicine for treatment of diabetes |
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| 张盈盈等: "浅谈犬糖尿病", 《广东畜牧兽医科技》 * |
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