CN108653526A - The prescription of Chinese traditional treatment myasthenia gravis - Google Patents

The prescription of Chinese traditional treatment myasthenia gravis Download PDF

Info

Publication number
CN108653526A
CN108653526A CN201810769810.1A CN201810769810A CN108653526A CN 108653526 A CN108653526 A CN 108653526A CN 201810769810 A CN201810769810 A CN 201810769810A CN 108653526 A CN108653526 A CN 108653526A
Authority
CN
China
Prior art keywords
parts
radix
chinese medicine
medicine composition
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201810769810.1A
Other languages
Chinese (zh)
Other versions
CN108653526B (en
Inventor
乞国艳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201810769810.1A priority Critical patent/CN108653526B/en
Publication of CN108653526A publication Critical patent/CN108653526A/en
Application granted granted Critical
Publication of CN108653526B publication Critical patent/CN108653526B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638—Ligustrum, e.g. Chinese privet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses a kind of Chinese medicine composition for treating myasthenia gravis, which is prepared by the bulk pharmaceutical chemicals of following parts by weight：10 100 parts of Radix Astragali, 10 30 parts of Radix Codonopsis, 10 24 parts of Rhizoma Atractylodis Macrocephalae, 5 10 parts of radix bupleuri, 5 10 parts of cimicifugae foetidae, 5 10 parts of Radix Angelicae Sinensis, 36 parts of Radix Glycyrrhizae, 36 parts of dried orange peel, 5 10 parts of matrimony vine, 9 12 parts of dogwood fruit, 5 12 parts of mulberries, 5 20 parts of Chinese yam, 15 30 parts of spina date seed, 6 15 parts of the seed of Oriental arborvitae, 10 15 parts of radix rehmanniae preparata, 10 15 parts of Radix Rehmanniae, 6 24 parts of Radix Salviae Miltiorrhizae, 15 parts of Schisandra chinensis, 6 12 parts of the fruit of glossy privet.The present invention is by the rational proportion of each Chinese medicine material, and using the synergistic effect between each component, the effect of making it have good treatment myasthenia gravis.

Description

The prescription of Chinese traditional treatment myasthenia gravis
Technical field
The invention belongs to Chinese traditional treatment fields, are related to a kind of Chinese medicine composition for treating myasthenia gravis.
Background technology
Myasthenia gravis (MG) is a kind of autoimmune disease by caused by neuromuscular junction transfer function obstacle Disease, clinical manifestation are part or whole body skeletal muscle weakness and fatiguability, and exacerbation of symptoms after activity, symptom subtracts after rest Gently.Illness rate is 77~15,0/1,000,000, and annual morbidity is 4~1,1/1,000,000.Women illness rate be more than male, about 3：2, each year Age Duan Jun has a morbidity, and children 1~5 years old are in the majority.
The pathogenic factor of myasthenia gravis divides two major classes, one kind to be inborn genetics, and Ji Shaojian is unrelated with autoimmunity； Second class is autoimmune disease, most common.Pathogenic factor is still not clear, and generally believes and infects, drug, environmental factor have It closes.There is in Patients With Myasthenia Gravis 65%~80% to have a thymic hyperplasia simultaneously, 10%~20% occurs together thymoma.
Myasthenia gravis initial stage patient often feels eye or the swollen discomfort of limbs acid or blurred vision, is easy fatigue, day Tired exacerbation when gas sweltering heat or menstrual onset.With progression of the disease, the apparent fatigue and weak of skeletal muscle, distinguishing feature be myasthenia in Afternoon or at dusk tired postemphasis, mitigate from morning or after rest, and such phenomenon is referred to as " morning light dusk weight ".
Diagnosis：(1) according to involvement muscle group weak, to show as morning light, afternoon or aggravates at dusk, recoverable feature after rest, Neurological examination finder without exception, can generally make diagnosis.(2) fatigue test can be done to suspicious patient, intramuscular can also notes 0.5~1.0mg of neostigmine is penetrated, 30min to 1h is observed, the muscular strength person of making progress can determine diagnosis.(3) performance of Cardiac Involvemant.
Treatment：(1) anticholinesterase is the drug of symptomatic treatment, palliative, cannot single medicine prolonged application, use Prescription method should be cumulative from low dose.There are commonly neostigmine methyl sulfate, Pyridostigmine Bromides.(2) immunosupress is commonly exempted from Epidemic disease inhibitor is：1. Corticosteroid：Prednisone, methylprednisolone etc.；2. imuran；3. cyclosporin A； 4. cycli phosphate amine；5. tacrolimus.(3) plasma exchange by blood samples of patients acetylcholine receptor antibodies removal by way of, The symptom of respite Patients With Myasthenia Gravis, if do not assisted other treatment mode, curative effect to be no more than 2 months.(4) it is injected intravenously Contain Multiple Antibodies in immunoglobulin human immunoglobulin, autoantibody can be neutralized, adjust immune function.Its effect with Plasma exchange is suitable.(5) Chinese traditional treatment of Chinese medicine myasthenia gravis is increasingly taken seriously.Myasthenia gravis category " impotence Disease " scope.According to theory of traditional Chinese medical science, adds use traditional Chinese medicine in the treatment, it is possible to reduce the side effect that immunosuppressor is brought, in weight The effect of playing a part of escorting in the treatment of disease myasthenia, and autoimmune function can be rebuild.
Invention content
The purpose of the present invention is to provide a kind of Chinese medicine composition for treating myasthenia gravis, the Chinese medicine composition by with The bulk pharmaceutical chemicals of lower parts by weight are prepared：Radix Astragali (Astragalus membranaceus (Fisch.) Bge.), Radix Codonopsis (RADIX CODONOPSIS), Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala), radix bupleuri (Radix Bupleuri), cimicifugae foetidae (RHIZOMA CIMICIFUGAE), Radix Angelicae Sinensis (Angelica sinensis (Oliv.) Diels.), Radix Glycyrrhizae (Glycyrriza Uralensis Fisch.G.Glabra L.), dried orange peel (PERICARPIUM), matrimony vine (Fructus Lycii), dogwood fruit (Cornus Officinalis Sieb.Et Zucc.), mulberries (Fructus mori), Chinese yam (Dioscorea opposita), spina date seed It is (Ziziphus jujuba Mill.var.spinosa), the seed of Oriental arborvitae (Platycladus orientalis (Linn.)), ripe Ground (Rehmannia glutinosa (Gaetn.) Libosch.ex Fisch.et Mey.), Radix Rehmanniae (Rehmannia Glutinosa (Gaetn.) Libosch.ex Fisch.et), Radix Salviae Miltiorrhizae (Radix Salviae Miltiorrhizae), the five tastes Sub (Fructus Schisandrae Chinensis), the fruit of glossy privet (Fructus Ligustri Lucidi).The present invention passes through The rational proportion of each Chinese medicine material, and using the synergistic effect between each component, make it have good treatment myasthenia gravis Chinese medicine composition.
To achieve the goals above, present invention employs following technical solutions：
According to an aspect of the present invention, described the present invention provides a kind of Chinese medicine composition for treating myasthenia gravis Chinese medicine composition is prepared by the bulk pharmaceutical chemicals of following parts by weight：10-100 parts of Radix Astragali, 10-30 parts of Radix Codonopsis, 10-24 parts of Rhizoma Atractylodis Macrocephalae, 5-10 parts of radix bupleuri, 5-10 parts of cimicifugae foetidae, 5-10 parts of Radix Angelicae Sinensis, 3-6 parts of Radix Glycyrrhizae, 3-6 parts of dried orange peel, 5-10 parts of matrimony vine, 9-12 parts of dogwood fruit, 5-12 parts of mulberries, 5-20 parts of Chinese yam, 15-30 parts of spina date seed, 6-15 parts of the seed of Oriental arborvitae, 10-15 parts of radix rehmanniae preparata, 10-15 parts of Radix Rehmanniae, Radix Salviae Miltiorrhizae 6-24 parts, 15 parts of Schisandra chinensis, 6-12 parts of the fruit of glossy privet.
Preferably, the Chinese medicine composition is prepared by the bulk pharmaceutical chemicals of following parts by weight：50 parts of Radix Astragali, 20 parts of Radix Codonopsis, 15 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of radix bupleuri, 8 parts of cimicifugae foetidae, 8 parts of Radix Angelicae Sinensis, 5 parts of Radix Glycyrrhizae, 4 parts of dried orange peel, 8 parts of matrimony vine, 10 parts of dogwood fruit, 8 parts of mulberries, 12 parts of Chinese yam, 20 parts of spina date seed, 10 parts of the seed of Oriental arborvitae, 12 parts of radix rehmanniae preparata, 12 parts of Radix Rehmanniae, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of Schisandra chinensis, the fruit of glossy privet 10 Part.
Radix Astragali meridian distribution of property and flavor：It is sweet, tepor；Returns spleen, lung channel.Effect：Invigorating qi for consolidating superficies, tonifying Qi and lifting yang, promoting pus discharge and tissue regeneration, Li Shui disappear It is swollen.It cures mainly：For treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, from juice night sweat, blood deficiency chlorosis, cloudy subcutaneous ulcer is unrestrained swollen, gas Empty oedema, Heat Diabetes.
Radix Codonopsis meridian distribution of property and flavor：Sweet and neutral.Returns spleen, lung channel.Effect：Tonifying middle-Jiao and Qi, shengjin nourishing.It cures mainly：Not for middle gas Foot, anorexia and loose stool, cough and asthma shortness of breath, injury thirst, blood deficiency chlorosis, palpitation and dizziness.
Seed of Oriental arborvitae meridian distribution of property and flavor：Sweet and neutral.The thoughts of returning home, kidney, large intestine channel.Effect：Mental-tranquilization relaxes bowel.It cures mainly：For Restlessness of asrhenia type and insomnia, palpitation of palpitating with fear, dry constipation of intestines.
Schisandra chinensis meridian distribution of property and flavor：Acid, temperature.Return lung, kidney, the heart channel of Hang-Shaoyin.Effect：It astringes the lung nourshing kidney, promote the production of body fluid arrest sweating, puckery essence antidiarrheal, rather Heart and tranquilizing mind.It cures mainly：For chronic cough and dyspnea of deficiency type, injury thirst, spontaneous sweating, emission due to the kidney deficiency, spleen kidney deficiency rushes down, palpitation and insomnia.
Radix Salviae Miltiorrhizae meridian distribution of property and flavor：Hardship is slightly cold.The thoughts of returning home, pericardium, Liver Channel.Effect：Promoting blood circulation, cool blood to disappear carbuncle, nourishing blood and tranquilization. It cures mainly：For irregular menstruation, trusted subordinate's pain , lumps in the chest and abdomen, beriberoid pyretic arthralgia, sore swell and ache curative, agitation is insomnia, palpitaition, insomnia.
Radix rehmanniae recen meridian distribution of property and flavor：It is sweet, bitter, it trembles with fear.The thoughts of returning home, liver and kidney channel.Effect：Clearing heat and cooling blood, nourishing Yin and promoting production of body fluid.It cures mainly：For Vexed, tongue is deep red, blood-head tells nosebleed, atropurpureus macula, consumption of YIN caused by febrile disease, more drinks of quenching one's thirst.
Cimicifugae foetidae meridian distribution of property and flavor：It is pungent, sweet, it is slightly cold.Return lung, spleen, large intestine, stomach.Effect：Deliver promoting eruption, clearing heat and detoxicating, liter act Yang-energy.It cures mainly：For headache due to pathogenic wind-heat, measles is unsmooth, dentalgia aphtha, abscess of throat, visceral organ ptosis.
Radix bupleuri meridian distribution of property and flavor：It is bitter, pungent, be slightly cold.Thoughts of returning home envelope, liver, courage, tri-jiao channel.Effect：Evacuation is brought down a fever, soothing liver-qi stagnation, It rises and lifts yang-energy.It cures mainly：For cold, fever, fevers and chills alternate, the distending pain in hypochondrium, irregular menstruation, rectal prolapse, the prolapse of uterus.
Radix Glycyrrhizae meridian distribution of property and flavor：Sweet and neutral.The thoughts of returning home, spleen, lung, stomach.Effect：It invigorates the spleen and benefits qi, moistens the lung and relieve the cough, it is clearing heat and detoxicating, delay Solution analgesic, mitigates pharmacological property.It cures mainly：For weakness of the spleen and the stomach, shortness of breath and fatigue, palpitation and severe palpitation, cough phlegm is few, pathopyretic ulcer, in medicine food Poison, gastral cavity abdomen shoot, four limbs contraction pain.
Dried orange peel meridian distribution of property and flavor：Acrid flavour, hardship, it is warm-natured.Returns spleen, stomach, lung channel.Effect：Qi-regulating is eliminating dampness and eliminating phlegm in, and Li Shui is logical Just.It cures mainly：Incoordination between the spleen and the stomach, abdominal distention, do not feel like eating vomits hiccup, and phlegm-damp obstructing lung, coughing with a lot of sputum, chest and diaphragm expire vexed, the head is dizzy It is dizzy, oedema, difficult urination, constipation, acute mastitis sore tinea, middle ichthyophagy crab poison, wine poison.
Fruit of Chinese wolfberry meridian distribution of property and flavor：It is mild-natured, it is sweet in flavor.Entering Liver Channel, kidney channel, lung channel, (internal organs belong to：In return liver warp, kidney channel, lung channel Medicine).Effect：It is nourishing liver and kidney, improving eyesight, moistening lung.It cures mainly：For vertigo and head dark, seminal emission is quenched one's thirst, deficiency of yin and overstrain cough.
Dogwood fruit meridian distribution of property and flavor：Sour-puckery flavor, slightly warm in nature.Return liver, kidney channel.Function：Filling liver kidney, puckery vital essence, Gu collapse.It is main It controls：Soreness of waist and knee joint, positive " impotence " are passed out semen, frequent urination, under uterine bleeding band, liver cold of insufficiency type heat, and profuse sweating collapse, Heat Diabetes, dizziness and tinnitus Deng.
Mulberry fruit meridian distribution of property and flavor：It is sweet, it trembles with fear.The thoughts of returning home, liver and kidney channel.Effect：Nourishing yin and supplementing blood, ease constipation are promoted the production of body fluid.It cures mainly：For yin deficiency The deficiency of blood, the deficiency of Yin are quenched one's thirst, and body fluid deficiency is thirsty, dizziness and tinnitus, dry constipation of intestines.
Spina date seed meridian distribution of property and flavor：It is mild-natured, it is sweet in flavor.Enter the heart channel of Hang-Shaoyin, (internal organs belong to Liver Channel：Thoughts of returning home warp, Liver Channel Chinese medicine).Effect： Mental-tranquilization, arrest sweating.It cures mainly：For having a sleepless night, palpitation with fear, spontaneous perspiration, night sweat.
Rhizoma Atractylodis Macrocephalae meridian distribution of property and flavor：Bitter, sweet, warm；Returns spleen, stomach.Effect：Air making-up and spleen enlivening, eliminate dampness and have diuretic effect, hidroschesis, tocolysis.It is main It controls：For deficiency-weakness of spleen-QI, anorexia and loose stool, phlegm and retained fluid oedema, exterior deficiency spontaneous perspiration, fetal irritability.
Radix Angelicae Sinensis meridian distribution of property and flavor：Sweet, acrid, warm.Return liver, the heart, the spleen channel.Effect：Promoting blood circulation and stopping pain, tonifying blood and regulating menstruation relax bowel.It is main It controls：For dizziness due to deficiency of blood, irregular menstruation, Amenorrhea, dysmenorrhoea, sallow complexion, asthenia cold abdominalgia, traumatic injury, arthralgia pain due to rheumatism, ulcer sore Ulcer, dry constipation of intestines.
Prepared rehmannia root meridian distribution of property and flavor：It is sweet, tepor.Return liver and kidney channel.Effect：Nourishing the blood and yin, enriching essence and nourishing marrow.It cures mainly：For the deficiency of blood Sallow, dizziness palpitaition, irregular menstruation, hectic fever night sweat quenches one's thirst, soreness of waist tinnitus.
Radix Salviae Miltiorrhizae meridian distribution of property and flavor：Hardship is slightly cold.The thoughts of returning home, pericardium, Liver Channel.Radix Salviae Miltiorrhizae effect：Promoting blood circulation, cool blood to disappear carbuncle, blood-nourishing peace God.It cures mainly：For irregular menstruation, trusted subordinate's pain , lumps in the chest and abdomen, beriberoid pyretic arthralgia, sore swell and ache curative, agitation is insomnia, palpitaition, insomnia.
Chinese yam meridian distribution of property and flavor：Sweet and neutral.Returns spleen, lung, kidney channel.Effect：Supplementing qi and nourishing yin, help spleen and lung, invigorates the kidney and stops nocturnal emission.It cures mainly： For spleen eating less, diarrhea with loose stool, deficiency syndrome of the lung cough and asthma, frequent micturition of passing out semen, the deficiency of Yin quenches one's thirst.
According to another aspect of the present invention, described the present invention provides a kind of pharmaceutical preparation for treating myasthenia gravis Pharmaceutical preparation is that pharmaceutically acceptable auxiliary material is added by foregoing Chinese medicine composition to be prepared.
Further, the pharmaceutical preparation includes peroral dosage form.
Further, the oral preparation include pill, tablet, soft capsule, powder, granule, capsule, Oral solution.
According to a further aspect of the invention, the present invention provides a kind of preparation sides of foregoing Chinese medicine composition Method, the preparation method include：It by the bulk pharmaceutical chemicals extracting in water in foregoing Chinese medicine composition, filters, concentration.
In more detail, foregoing preparation method includes：By the bulk pharmaceutical chemicals described in foregoing Chinese medicine composition, It smashs into coarse powder to pieces, the 8-10 times of water for measuring volume is added to decoct twice, 2 hours every time, merge extracting solution；It is concentrated under reduced pressure, is made described Chinese medicine composition.
According to a further aspect of the invention, described the present invention provides the preparation method of foregoing pharmaceutical preparation Preparation method includes：Method as described above prepares Chinese medicine composition, is added and pharmaceutically commonly uses auxiliary material, with galenic pharmacy routine Technology is prepared into foregoing pharmaceutical preparation.
In detail, after pharmaceutical composition of the invention is mixed with pharmaceutically acceptable adjunct ingredient, by corresponding conventional medicine Object formulation method can prepare the drug for the treatment of myasthenia gravis.For example, with disintegrant, excipient, lubricant, adhesive, fill out After filling the common auxiliary adding ingredient mixing such as agent, operating method routinely and process can be made for tablet, pill, capsule The drug of the solid orally ingestibles form such as agent or a variety of corresponding sustained release agents, controlled release agent；With conventional solubilizer, emulsifier, profit After the mixing such as the surfactants such as humectant, blistering or antifoaming agent, diluent, preservative, stabilizer, corrigent, thickener, by phase The conventional method answered can be prepared as the oral drugs of the liquid forms such as aqua, syrup, oral solution；It is hanged with conventional Floating agent, stabilizer, dispersant or the reagent mixing for adjusting solution osmotic pressure, by corresponding conventional method, are configured to injection.
According to a further aspect of the invention, the present invention provides foregoing Chinese medicine compositions to prepare treatment severe Application in the drug of myasthenia.
Preferably, myasthenia gravis of the invention is the myasthenia gravis that deficiency of both qi and yin adds deficiency of heart-blood.
The advantages of the present invention：
The bulk pharmaceutical chemicals abundance of the Chinese medicine composition of the present invention, naturally, preparation process is simple, manufacturing cost is low, curative effect It is good, safe without side-effects, suitable for clinically promoting the use of.
Specific implementation mode
In order to better understand and implement, is further illustrated the present invention with reference to embodiment.Unless otherwise specified, this hair Bright embodiment is only used for explaining the present invention, is not meant to limit protection scope of the present invention.
The Chinese medicine composition and pharmaceutical preparation of the present invention sieves under the premise of with theory of traditional Chinese medical science basis through scientific formula Choosing, it is refined to be process under the premise of taking science extraction process using Chinese medicine.
The preparation of 1 Chinese medicine composition of embodiment
1, the following Chinese medicine material of precise：100 parts of Radix Astragali, 30 parts of Radix Codonopsis, 24 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of radix bupleuri, 10 parts of cimicifugae foetidae, 10 parts of Radix Angelicae Sinensis, 6 parts of Radix Glycyrrhizae, 6 parts of dried orange peel, 10 parts of matrimony vine, 12 parts of dogwood fruit, 12 parts of mulberries, 20 parts of Chinese yam, 30 parts of spina date seed, cypress 15 parts of sub- benevolence, 15 parts of radix rehmanniae preparata, 15 parts of Radix Rehmanniae, 24 parts of Radix Salviae Miltiorrhizae, 15 parts of Schisandra chinensis, 12 parts of the fruit of glossy privet.
2, it by the above bulk pharmaceutical chemicals, smashs into coarse powder to pieces, the water of 10 times of amount volumes is added to decoct twice, 2 hours every time, merge extraction Liquid；It is concentrated under reduced pressure, the Chinese medicine composition is made.
The preparation of 2 Chinese medicine composition of embodiment
1, the following Chinese medicine material of precise：50 parts of Radix Astragali, 20 parts of Radix Codonopsis, 15 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of radix bupleuri, 8 parts of cimicifugae foetidae, when Return 8 parts, 5 parts of Radix Glycyrrhizae, 4 parts of dried orange peel, 8 parts of matrimony vine, 10 parts of dogwood fruit, 8 parts of mulberries, 12 parts of Chinese yam, 20 parts of spina date seed, the seed of Oriental arborvitae 10 Part, 12 parts of radix rehmanniae preparata, 12 parts of Radix Rehmanniae, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of Schisandra chinensis, 10 parts of the fruit of glossy privet.
2, it by the above bulk pharmaceutical chemicals, smashs into coarse powder to pieces, the water of 9 times of amount volumes is added to decoct twice, 2 hours every time, merge extraction Liquid；It is concentrated under reduced pressure, the Chinese medicine composition is made.
The preparation of 3 Chinese medicine composition of embodiment
1, the following Chinese medicine material of precise：10 parts of Radix Astragali, 10 parts of Radix Codonopsis, 10 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of radix bupleuri, 5 parts of cimicifugae foetidae, when Return 5 parts, 3 parts of Radix Glycyrrhizae, 3 parts of dried orange peel, 5 parts of matrimony vine, 9 parts of dogwood fruit, 5 parts of mulberries, 5 parts of Chinese yam, 15 parts of spina date seed, 6 parts of the seed of Oriental arborvitae, 10 parts of radix rehmanniae preparata, 10 parts of Radix Rehmanniae, 6 parts of Radix Salviae Miltiorrhizae, 15 parts of Schisandra chinensis, 6 parts of the fruit of glossy privet.
2, it by the above bulk pharmaceutical chemicals, smashs into coarse powder to pieces, the water of 8 times of amount volumes is added to decoct twice, 2 hours every time, merge extraction Liquid；It is concentrated under reduced pressure, the Chinese medicine composition is made.
The preparation of 4 pharmaceutical preparation of embodiment
1, the preparation of oral solution
(1) clear cream of Chinese medicine composition is prepared according to the method for embodiment 1-3；
(2) 20% alcohol benzoate solution 5ml and 24% potassium sorbate solution 5ml is added, stirs evenly, refrigerates 48h or more, filter It crosses, adds water to adjust to every milliliter and contain crude drug 5.5g, stir evenly, embedding is to get oral solution.
2, the preparation of tablet
(1) clear cream of Chinese medicine composition is prepared according to the method in embodiment 1- embodiments 3；
(2) supplementary product starch, ethyl alcohol, talcum powder is added, tablet is made.
3, the preparation of capsule
(1) clear cream of Chinese medicine composition is prepared according to the method in embodiment 1- embodiments 3；
(2) supplementary product starch, ethyl alcohol, dextrin, magnesium stearate is added, is packed into capsule shells, capsule is made.
4, the preparation of granule
(1) Chinese medicine composition clear cream is prepared according to the method in embodiment 1- embodiments 3；
(2) auxiliary material Icing Sugar, starch, dextrin, ethyl alcohol is added, granule is made.
The effect of 5 pharmaceutical preparation of embodiment
1, the preparation of experimental drug
Oral solution is prepared according to the method for embodiment 4.
2, crowd is tested
The Patients With Myasthenia Gravis 75 that deficiency of both qi and yin adds deficiency of heart-blood is collected, is divided into 3 groups.It takes according to embodiment 1 The patient of oral solution prepared by prescription is 1 group, and the patient for taking the oral solution prepared according to the prescription of embodiment 2 is 2 groups, is taken The patient of the oral solution prepared according to the prescription of embodiment 3 is 3 groups.
Diagnostic criteria：
(1) clinical manifestation：Ptosis or dysraphism, weakness of limbs chew dysphagia, glossolalia, and sound is neighed Mute, expiratory dyspnea etc., the above performance partly or entirely occurs.
(2) fatigue test is positive：Observation involvement muscle group, regard on eye be less than 60 seconds it is sagging, double upper limbs are flat lift and be less than 120 seconds under It hangs down, double lower limb is praised sagging less than 120 seconds.
(3) neostigmine test is positive
With 1-1.5 milligrams of intramuscular injection of neostigmine methyl sulfate, can while subcutaneously be noted to eliminate its M choline system side effect Penetrate 0.5 milligram of atropine.Observation involvement muscle group, judged with clinical opposite point-score as a result, observe 60 minutes, be as a result more than 80% is the positive, and 25%-80% is suspicious, is less than 25% for feminine gender.
(4) EMG detection
Facial nerve, ulnar nerve, femoral nerve, Repetitive nerve stimulation decaying is selected (to be less than 5HZ to decay>5-15%), high frequency Repetitive nerve stimulation (is more than 10HZ to decay without incremental<30%).
(5) acetylcholine receptor antibodies value is equal>0.5ng/ml.(normal value<0.5ng/ml).
3, therapy：It 100ml/ times, takes day 2 times, continuous Time of Administration 1 week.
4, efficacy assessment standard：
It cures：Clinical symptoms disappear；
It is effective：Clinical symptoms are obviously improved, and are influenced on daily life slight；
Effectively：Clinical symptoms improve, and influence daily life to a certain degree；
In vain：Clinical symptoms are unchanged or aggravate.
5, efficacy result
Specific data ginseng is shown in Table 1.
1 efficacy result of table counts
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that The specific implementation of the present invention is confined to these explanations.For those of ordinary skill in the art to which the present invention belongs, exist Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to the present invention's Protection domain.

Claims (10)

1. a kind of Chinese medicine composition for treating myasthenia gravis, which is characterized in that the Chinese medicine composition is by following parts by weight Bulk pharmaceutical chemicals are prepared：10-100 parts of Radix Astragali, 10-30 parts of Radix Codonopsis, 10-24 parts of Rhizoma Atractylodis Macrocephalae, 5-10 parts of radix bupleuri, 5-10 parts of cimicifugae foetidae, when Return 5-10 parts, 3-6 parts of Radix Glycyrrhizae, 3-6 parts of dried orange peel, 5-10 parts of matrimony vine, 9-12 parts of dogwood fruit, 5-12 parts of mulberries, 5-20 parts of Chinese yam, acid 15-30 parts of jujube kernel, 6-15 parts of the seed of Oriental arborvitae, 10-15 parts of radix rehmanniae preparata, 10-15 parts of Radix Rehmanniae, 6-24 parts of Radix Salviae Miltiorrhizae, 15 parts of Schisandra chinensis, the fruit of glossy privet 6-12 parts.
2. Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition by following parts by weight bulk pharmaceutical chemicals It is prepared：50 parts of Radix Astragali, 20 parts of Radix Codonopsis, 15 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of radix bupleuri, 8 parts of cimicifugae foetidae, 8 parts of Radix Angelicae Sinensis, 5 parts of Radix Glycyrrhizae, 4 parts of dried orange peel, 8 parts of matrimony vine, 10 parts of dogwood fruit, 8 parts of mulberries, 12 parts of Chinese yam, 20 parts of spina date seed, 10 parts of the seed of Oriental arborvitae, 12 parts of radix rehmanniae preparata, 12 parts of Radix Rehmanniae, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of Schisandra chinensis, 10 parts of the fruit of glossy privet.
3. a kind of pharmaceutical preparation for treating myasthenia gravis, which is characterized in that the pharmaceutical preparation is by claims 1 or 2 institute The Chinese medicine composition stated is added pharmaceutically acceptable auxiliary material and is prepared.
4. pharmaceutical preparation according to claim 3, which is characterized in that the pharmaceutical preparation includes peroral dosage form.
5. pharmaceutical preparation according to claim 4, which is characterized in that the oral preparation includes pill, tablet, flexible glue Wafer, powder, granule, capsule, oral solution.
6. the preparation method of Chinese medicine composition as claimed in claim 1 or 2, which is characterized in that the preparation method includes：It will power Profit requires 1 or 2 bulk pharmaceutical chemicals to add water or alcohol extracting, filters, concentration.
7. preparation method according to claim 6, which is characterized in that the preparation method includes：By claims 1 or 2 The bulk pharmaceutical chemicals, smash into coarse powder to pieces, and the 8-10 times of water for measuring volume is added to decoct twice, 2 hours every time, merge extracting solution；Decompression The Chinese medicine composition is made in concentration.
8. the preparation method of the pharmaceutical preparation described in any one of claim 3-5, which is characterized in that the preparation method packet It includes：Chinese medicine composition is prepared according to the method for claim 6, is added and pharmaceutically commonly uses auxiliary material, is prepared with galenic pharmacy routine techniques At the pharmaceutical preparation described in any one of claim 3-5.
9. application of the Chinese medicine composition of claims 1 or 2 in the drug for preparing treatment myasthenia gravis.
10. application according to claim 9, which is characterized in that the myasthenia gravis is that deficiency of both qi and yin adds deficiency of heart-blood Myasthenia gravis.
CN201810769810.1A 2018-07-13 2018-07-13 Traditional Chinese medicine formula for treating myasthenia gravis Active CN108653526B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810769810.1A CN108653526B (en) 2018-07-13 2018-07-13 Traditional Chinese medicine formula for treating myasthenia gravis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810769810.1A CN108653526B (en) 2018-07-13 2018-07-13 Traditional Chinese medicine formula for treating myasthenia gravis

Publications (2)

Publication Number Publication Date
CN108653526A true CN108653526A (en) 2018-10-16
CN108653526B CN108653526B (en) 2021-03-16

Family

ID=63772768

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810769810.1A Active CN108653526B (en) 2018-07-13 2018-07-13 Traditional Chinese medicine formula for treating myasthenia gravis

Country Status (1)

Country Link
CN (1) CN108653526B (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104069339A (en) * 2014-06-18 2014-10-01 乞国艳 Traditional Chinese medicine composition for treating myasthenia gravis and preparation method thereof
CN104147455A (en) * 2014-08-27 2014-11-19 中南林业科技大学 Preparation for treating ocular myasthenia gravis
CN105535448A (en) * 2016-03-07 2016-05-04 乞国艳 Traditional Chinese medicine composition for treating child myasthenia gravis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104069339A (en) * 2014-06-18 2014-10-01 乞国艳 Traditional Chinese medicine composition for treating myasthenia gravis and preparation method thereof
CN104147455A (en) * 2014-08-27 2014-11-19 中南林业科技大学 Preparation for treating ocular myasthenia gravis
CN105535448A (en) * 2016-03-07 2016-05-04 乞国艳 Traditional Chinese medicine composition for treating child myasthenia gravis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
顾维超: "《中医内科学》", 31 October 1998, 东南大学出版社 *

Also Published As

Publication number Publication date
CN108653526B (en) 2021-03-16

Similar Documents

Publication Publication Date Title
CN104873705A (en) Medicinal composition for treating angina pectoris of coronary heart disease and application thereof
CN102526498A (en) Chinese medicine for eliminating toxic and side effects after nasopharyngeal carcinoma radiotherapy and preparation method and administration way thereof
CN103341092B (en) Preparation method of powder for treating atrophic vaginitis
CN104524071A (en) Pharmaceutical composition for treating primary renal disease and application thereof
CN103301353B (en) Pharmaceutical composition for treating atrophic vaginitis
CN105106872A (en) Traditional Chinese medicine composition for treating coronary heart diseases and preparation method of traditional Chinese medicine composition
CN102293985B (en) Traditional Chinese medicine composition used for treating coronary heart disease and preparation method thereof
CN103860773A (en) Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof
CN105497262A (en) Medicine composition for treating liver-yin and kidney-yin deficiency type polycystic ovarian syndrome
CN108653526A (en) The prescription of Chinese traditional treatment myasthenia gravis
CN105233078A (en) Traditional Chinese medicine composition for treating viral hepatitis
CN104998158A (en) Pharmaceutical composition for treating liver cirrhosis and application thereof
CN110101800A (en) It is a kind of to treat malignant pleural effusion Chinese medicine composition and its application
CN103330896B (en) Preparation method of powder for treating postpartum nonspecific vaginitis
CN103301374B (en) Pharmaceutical composition for treating postpartum non-specificity vaginitis
CN106266334A (en) A kind of Chinese medicine composition treating fat concurrent hyperlipemia and acupuncture and drugs application
CN105920436A (en) Medicinal preparation for treating lung cancer and preparation method thereof
CN105535199A (en) Pharmaceutical preparation for treating polycystic ovarian syndromes accompanied with mammary gland hyperplasia
CN105287829A (en) Chinese herb composition for treating nephritic syndrome and preparation method
CN104491182A (en) Traditional Chinese medicine for reducing side effects of chemotherapy and preparation method
CN104800568A (en) Traditional Chinese medicinal capsules used for alleviating postpartum constipation
CN104208427A (en) Pharmaceutical preparation for treating nephritic syndrome and preparation method thereof
CN104096212A (en) Traditional Chinese medicine application for treating myocardial infarction and application for same
CN103356970A (en) Traditional Chinese medicine composition for treating mammary gland hyperplasia
CN103316270A (en) Preparation method of powder of medicine for treating postnatal perineum mucosal lesion

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant