CN108653513A - A kind of Chinese medicine composition for treating dizziness - Google Patents
A kind of Chinese medicine composition for treating dizziness Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions for treating dizziness, include the raw material of following parts by weight:45~55 parts of Radix Salviae Miltiorrhizae, 18~22 parts of Poria cocos, 18~22 parts of Rhizoma Atractylodis Macrocephalae, 18~22 parts of the tuber of pinellia, 18~22 parts of dried orange peel, 18~22 parts of the dried immature fruit of citron orange, 15~25 parts of pueraria lobata, 15~25 parts of rhodiola root, 25~35 parts of ginkgo leaf, 25~35 parts of radix achyranthis bidentatae, 10~20 parts of Radix Angelicae Sinensis, 12~18 parts of uncaria, 20~30 parts of Prunella vulgaris, 18~22 parts of Cortex Eucommiae, 4~8 parts of Radix Glycyrrhizae.Chinese medicine composition proposed by the present invention, formula is reasonable, and stability is good, and drug effect is high, Small side effects, cure rate is high, recurrence rate is low, convenient to take, and there is Huatan Zhuyu, the promoting flow of qi and blood circulation, ceases wind to stop dizzy effect, dizziness is fast and effectively treated from root, and preparation process is simple, extraction efficiency is high, small to the destruction of active ingredient, extracted amount is big.
Description
Technical field
The invention belongs to biopharmaceutical technology more particularly to a kind of Chinese medicine compositions for treating dizziness.
Background technology
Dizziness is one of illness common in daily life, is found in a variety of diseases of doctor trained in Western medicine, as cerebral arteriosclerosis,
High blood pressure, hyperlipidemia, transient ischemic attack, labyrinthine syndrome, vertebral-basilar artery insufficiency etc..Mechanism of qi is strongly fragrant
Stagnant, with the passing of time gas stops blood stasis, body fluid dysbolism, forms phlegm wet, and phlegm wet can aggravate hemostasis, and phlegm-blood stasis often mutually becomes disease.《Bright doctor is miscellaneous
It》In " if blood foul smell is stagnant, cohesion be phlegm, the deficiency of vital energy bloody sputum drink for speech." clearly propose phlegm-blood stasis and often mutually become disease.Modern age cures
Family controls dizzy side and mostly sets about from phlegm-blood stasis.It can be seen that phlegm, the stasis of blood are all to lead to the common disease factor of dizziness.Phlegm-blood stasis cause is dizzy to be divided into following two
Kind:On the one hand, phlegm and blood stasis, burnt in retardance, lucid yang failing to raise, blood is not upper flourish and causes dizzy;On the other hand, the direct superinverse of phlegm-blood stasis is covered
It covers clear key and causes dizzy.The common dizziness of phlegm and blood stasis dizziness, tinnitus, dizzy heavy, limb fiber crops are heavy, heaviness of the head as if it were tightly bandaged, limbs are sleepy, tongue nature
It is purple it is dim, tongue fur is satiny, wiry and rolling pulse even it is simultaneous see hiccup, vomiting, the obstruction of qi in the chest have a pain, have a sleepless night, palpitaition.
The Western medicine side effect of traditional treatment dizziness is bigger, and dependence is strong, only palliative;And compared to Western medicine,
The therapy of Chinese medicine both took stopgap measures or effected a permanent cure, and toxic side effect is small, but there are still certain drawbacks, such as existing treatment dizziness
Chinese medicine be mostly decoction, mouthfeel is not good enough, takes inconvenience, and the recovery rate of medicinal material is low, and quality standard is uncontrollable etc..Based on the prior art
Existing deficiency, the present invention propose a kind of Chinese medicine composition of the rational treatment dizziness of formula.
Invention content
The purpose of the present invention is to solve disadvantages existing in the prior art, and a kind of Chinese medicine that treating dizziness proposed
Composition.
A kind of Chinese medicine composition for treating dizziness, includes the raw material of following parts by weight:45~55 parts of Radix Salviae Miltiorrhizae, Poria cocos 18~22
Part, 18~22 parts of Rhizoma Atractylodis Macrocephalae, 18~22 parts of the tuber of pinellia, 18~22 parts of dried orange peel, 18~22 parts of the dried immature fruit of citron orange, 15~25 parts of pueraria lobata, rhodiola root 15
~25 parts, 25~35 parts of ginkgo leaf, 25~35 parts of radix achyranthis bidentatae, 10~20 parts of Radix Angelicae Sinensis, 12~18 parts of uncaria, Prunella vulgaris 20~30
Part, 18~22 parts of Cortex Eucommiae, 4~8 parts of Radix Glycyrrhizae.
Preferably, the Chinese medicine composition includes the raw material of following parts by weight:50 parts of Radix Salviae Miltiorrhizae, 20 parts of Poria cocos, Rhizoma Atractylodis Macrocephalae 20
Part, 20 parts of the tuber of pinellia, 20 parts of dried orange peel, 20 parts of the dried immature fruit of citron orange, 20 parts of pueraria lobata, 20 parts of rhodiola root, 30 parts of ginkgo leaf, 30 parts of radix achyranthis bidentatae, Radix Angelicae Sinensis
15 parts, 15 parts of uncaria, 25 parts of Prunella vulgaris, 20 parts of Cortex Eucommiae, 6 parts of Radix Glycyrrhizae.
Preferably, the Radix Salviae Miltiorrhizae, pueraria lobata, rhodiola root, ginkgo leaf, radix achyranthis bidentatae, Radix Angelicae Sinensis mass ratio be 2.25~5.5:
0.75~2.5:0.75~2.5:1.25~3.5:1.25~3.5:1.
Preferably, the preparation type of the Chinese medicine composition is capsule.
The invention also provides a kind of preparation methods of Chinese medicine composition that treating dizziness, include the following steps:
S1, the pueraria lobata for taking corresponding parts by weight, rhodiola root, ginkgo leaf, radix achyranthis bidentatae, uncaria and Cortex Eucommiae add the second of 6~8 times of amounts
Alcohol extracting 1~3 time, 0.5~2h, Extracting temperature are 70~80 DEG C every time, and filtering is concentrated under reduced pressure, vacuum drying, then crushes, mistake
Sieve gets dry extract powder A, spare;
S2, the Poria cocos for taking corresponding parts by weight, the tuber of pinellia, Prunella vulgaris and Radix Glycyrrhizae add the ethanol water of 8~10 times of amounts to decoct 4~6h,
Filtering is concentrated under reduced pressure, flocculate with chitosan, then crush, be sieved the powder B of getting dry extract, spare;
S3, the white book for taking corresponding parts by weight, the dried immature fruit of citron orange, dried orange peel and Radix Angelicae Sinensis supercritical CO2Fluid extraction volatile oil, and will wave
Hair oil is detached with the dregs of a decoction, and the volatile oil cyclic dextrin clathrate of separation obtains volatile oil inclusion complex, spare, and phase is added in the remaining dregs of a decoction
The Radix Salviae Miltiorrhizae and entrainer for answering parts by weight carry out supercritical CO again2Fluid extraction is concentrated under reduced pressure, is dried in vacuo, crushing, being sieved i.e. again
Get dry extract powder C, spare;
S4, dried cream powder A, dried cream powder B, dried cream powder C and volatile oil inclusion complex prepared by above-mentioned steps are uniformly mixed, and added
Add auxiliary material, then is pelletized, the encapsulated Chinese medicine composition up to treatment dizziness.
Preferably, the size of the sieve used in being sieved in the S1 steps, S2 steps and S3 steps is 100 mesh or more.
Preferably, the relative density of concentrate is 1.05~1.15 after being concentrated under reduced pressure in the S1 steps, the S2 steps
The relative density of concentrate is 1.20~1.24 after middle reduced pressure, and concentrate is relatively close after being concentrated under reduced pressure in the S3 steps
Degree is 1.15~1.25.
Preferably, in the S2 steps part of flocculate with chitosan be related to using asterism-effect surface method flocculates.
Chinese medicine composition proposed by the present invention, formula is reasonable, and stability is good, and drug effect is high, Small side effects, and cure rate is high, multiple
Hair rate is low, convenient to take, and there is Huatan Zhuyu, the promoting flow of qi and blood circulation, ceases wind to stop dizzy effect, fast and effectively treated from root dizzy
Dizzy, and preparation process is simple, extraction efficiency is high, small to the destruction of active ingredient, extracted amount is big;Rational proportion is added in composition
Radix Salviae Miltiorrhizae, pueraria lobata, rhodiola root, ginkgo leaf, radix achyranthis bidentatae and Radix Angelicae Sinensis, mutually collaboration coordinate other traditional Chinese medicine ingredients to play resolving sputum jointly again
Stop dizzy effect by the stasis of blood, the promoting flow of qi and blood circulation, ceases wind, the illness of dizziness is solved from root, not only took stopgap measures but also effected a permanent cure, Western medicine is avoided only to take stopgap measures
The phenomenon that not effecting a permanent cure;Different extracting methods is used according to the difference of Chinese medicine property in preparation process, extraction is carried out at the same time, carries
The extraction efficiency of high active ingredient, and supercritical CO is used to volatile oil2Fluids extraction extracts, and solves vapor and steams
Extraction efficiency when evaporating method extraction volatile oil is low, problem that extracted amount is few, and can be effectively retained heat sensitivity in Chinese medicine
Ingredient, then coordinate supercritical CO2Fluid adds entrainer to carry out second extraction, the active ingredient being sufficiently reserved in medicinal material, Jin Erti
The extraction efficiency of high medicinal material;Flocculate with chitosan part use Star point design-effect surface optimization, optimum condition predictability it is good,
Accuracy is high;And the dosage form of Chinese medicine composition proposed by the present invention is capsule, can cover the bad odor of drug, facilitate clothes
With, improve the stability of drug, and the action speed of drug in vivo can be improved, moreover it is possible to which the rate of release for delaying drug helps
In positioning release medicine.
Specific implementation mode
The present invention is made further to explain with reference to specific embodiment.
Embodiment one
The present invention proposes a kind of Chinese medicine composition for treating dizziness, includes the raw material of following parts by weight:50 parts of Radix Salviae Miltiorrhizae, Fu
20 parts of Siberian cocklebur, 20 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of the tuber of pinellia, 20 parts of dried orange peel, 20 parts of the dried immature fruit of citron orange, 20 parts of pueraria lobata, 20 parts of rhodiola root, 30 parts of ginkgo leaf, bosom
30 parts of the root of bidentate achyranthes, 15 parts of Radix Angelicae Sinensis, 15 parts of uncaria, 25 parts of Prunella vulgaris, 20 parts of Cortex Eucommiae, 6 parts of Radix Glycyrrhizae.
Preparation method includes the following steps:
S1, the pueraria lobata for taking corresponding parts by weight, rhodiola root, ginkgo leaf, radix achyranthis bidentatae, uncaria and Cortex Eucommiae add the ethyl alcohol of 7 times of amounts to carry
It takes 2 times, each 1h, Extracting temperature is 75 DEG C, and it is 1.05~1.15 to filter, be concentrated under reduced pressure into relative density, vacuum drying, then powder
Broken, sieving gets dry extract powder A, spare;
S2, the Poria cocos for taking corresponding parts by weight, the tuber of pinellia, Prunella vulgaris and Radix Glycyrrhizae add the ethanol water of 9 times of amounts to decoct 5h, filter, subtract
It is 1.20~1.24 that pressure, which is concentrated into relative density, flocculate with chitosan, then crush, be sieved the powder B of getting dry extract, spare;
S3, the white book for taking corresponding parts by weight, the dried immature fruit of citron orange, dried orange peel and Radix Angelicae Sinensis supercritical CO2Fluid extraction volatile oil, and will wave
Hair oil is detached with the dregs of a decoction, and the volatile oil cyclic dextrin clathrate of separation obtains volatile oil inclusion complex, spare, and phase is added in the remaining dregs of a decoction
The Radix Salviae Miltiorrhizae and entrainer for answering parts by weight carry out supercritical CO again2Fluid extraction, be concentrated under reduced pressure into again relative density be 1.15~
1.25, it is dried in vacuo, crushes, being sieved up to dried cream powder C, it is spare;
S4, dried cream powder A, dried cream powder B, dried cream powder C and volatile oil inclusion complex prepared by above-mentioned steps are uniformly mixed, and added
Add auxiliary material, then is pelletized, the encapsulated Chinese medicine composition up to treatment dizziness.
In the present invention, the size for the sieve used that is sieved in the S1 steps, S2 steps and S3 steps is 100 mesh or more;
In the S2 steps part of flocculate with chitosan be related to using asterism-effect surface method flocculates.
Embodiment two
The present invention proposes a kind of Chinese medicine composition for treating dizziness, includes the raw material of following parts by weight:50 parts of Radix Salviae Miltiorrhizae, Fu
20 parts of Siberian cocklebur, 18 parts of Rhizoma Atractylodis Macrocephalae, 22 parts of the tuber of pinellia, 20 parts of dried orange peel, 20 parts of the dried immature fruit of citron orange, 25 parts of pueraria lobata, 15 parts of rhodiola root, 30 parts of ginkgo leaf, bosom
30 parts of the root of bidentate achyranthes, 15 parts of Radix Angelicae Sinensis, 15 parts of uncaria, 30 parts of Prunella vulgaris, 20 parts of Cortex Eucommiae, 6 parts of Radix Glycyrrhizae.
Preparation method includes the following steps:
S1, the pueraria lobata for taking corresponding parts by weight, rhodiola root, ginkgo leaf, radix achyranthis bidentatae, uncaria and Cortex Eucommiae add the ethyl alcohol of 8 times of amounts to carry
It taking 3 times, each 0.5h, Extracting temperature is 80 DEG C, and it is 1.05~1.15 to filter, be concentrated under reduced pressure into relative density, vacuum drying, then
It crushes, sieving gets dry extract powder A, spare;
S2, the Poria cocos for taking corresponding parts by weight, the tuber of pinellia, Prunella vulgaris and Radix Glycyrrhizae add the ethanol water of 10 times of amounts to decoct 6h, filter,
It is 1.20~1.24 to be concentrated under reduced pressure into relative density, flocculate with chitosan, then crush, be sieved the powder B of getting dry extract, spare;
S3, the white book for taking corresponding parts by weight, the dried immature fruit of citron orange, dried orange peel and Radix Angelicae Sinensis supercritical CO2Fluid extraction volatile oil, and will wave
Hair oil is detached with the dregs of a decoction, and the volatile oil cyclic dextrin clathrate of separation obtains volatile oil inclusion complex, spare, and phase is added in the remaining dregs of a decoction
The Radix Salviae Miltiorrhizae and entrainer for answering parts by weight carry out supercritical CO again2Fluid extraction, be concentrated under reduced pressure into again relative density be 1.15~
1.25, it is dried in vacuo, crushes, being sieved up to dried cream powder C, it is spare;
S4, dried cream powder A, dried cream powder B, dried cream powder C and volatile oil inclusion complex prepared by above-mentioned steps are uniformly mixed, and added
Add auxiliary material, then is pelletized, the encapsulated Chinese medicine composition up to treatment dizziness.
In the present invention, the size for the sieve used that is sieved in the S1 steps, S2 steps and S3 steps is 100 mesh or more;
In the S2 steps part of flocculate with chitosan be related to using asterism-effect surface method flocculates.
Embodiment three
The present invention proposes a kind of Chinese medicine composition for treating dizziness, includes the raw material of following parts by weight:55 parts of Radix Salviae Miltiorrhizae, Fu
20 parts of Siberian cocklebur, 20 parts of Rhizoma Atractylodis Macrocephalae, 22 parts of the tuber of pinellia, 18 parts of dried orange peel, 20 parts of the dried immature fruit of citron orange, 20 parts of pueraria lobata, 25 parts of rhodiola root, 25 parts of ginkgo leaf, bosom
35 parts of the root of bidentate achyranthes, 15 parts of Radix Angelicae Sinensis, 15 parts of uncaria, 25 parts of Prunella vulgaris, 20 parts of Cortex Eucommiae, 8 parts of Radix Glycyrrhizae.
Preparation method includes the following steps:
S1, the pueraria lobata for taking corresponding parts by weight, rhodiola root, ginkgo leaf, radix achyranthis bidentatae, uncaria and Cortex Eucommiae add the ethyl alcohol of 8 times of amounts to carry
It takes 1 time, extracts 2h, Extracting temperature is 80 DEG C, and it is 1.05~1.15 to filter, be concentrated under reduced pressure into relative density, vacuum drying, then powder
Broken, sieving gets dry extract powder A, spare;
S2, the Poria cocos for taking corresponding parts by weight, the tuber of pinellia, Prunella vulgaris and Radix Glycyrrhizae add the ethanol water of 8 times of amounts to decoct 5h, filter, subtract
It is 1.20~1.24 that pressure, which is concentrated into relative density, flocculate with chitosan, then crush, be sieved the powder B of getting dry extract, spare;
S3, the white book for taking corresponding parts by weight, the dried immature fruit of citron orange, dried orange peel and Radix Angelicae Sinensis supercritical CO2Fluid extraction volatile oil, and will wave
Hair oil is detached with the dregs of a decoction, and the volatile oil cyclic dextrin clathrate of separation obtains volatile oil inclusion complex, spare, and phase is added in the remaining dregs of a decoction
The Radix Salviae Miltiorrhizae and entrainer for answering parts by weight carry out supercritical CO again2Fluid extraction, be concentrated under reduced pressure into again relative density be 1.15~
1.25, it is dried in vacuo, crushes, being sieved up to dried cream powder C, it is spare;
S4, dried cream powder A, dried cream powder B, dried cream powder C and volatile oil inclusion complex prepared by above-mentioned steps are uniformly mixed, and added
Add auxiliary material, then is pelletized, the encapsulated Chinese medicine composition up to treatment dizziness.
In the present invention, the size for the sieve used that is sieved in the S1 steps, S2 steps and S3 steps is 100 mesh or more;
In the S2 steps part of flocculate with chitosan be related to using asterism-effect surface method flocculates.
Example IV
The present invention proposes a kind of Chinese medicine composition for treating dizziness, includes the raw material of following parts by weight:50 parts of Radix Salviae Miltiorrhizae, Fu
18 parts of Siberian cocklebur, 22 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of the tuber of pinellia, 20 parts of dried orange peel, 20 parts of the dried immature fruit of citron orange, 25 parts of pueraria lobata, 25 parts of rhodiola root, 30 parts of ginkgo leaf, bosom
30 parts of the root of bidentate achyranthes, 20 parts of Radix Angelicae Sinensis, 15 parts of uncaria, 25 parts of Prunella vulgaris, 20 parts of Cortex Eucommiae, 4 parts of Radix Glycyrrhizae.
Preparation method includes the following steps:
S1, the pueraria lobata for taking corresponding parts by weight, rhodiola root, ginkgo leaf, radix achyranthis bidentatae, uncaria and Cortex Eucommiae add the ethyl alcohol of 6 times of amounts to carry
It takes 2 times, each 2h, Extracting temperature is 70 DEG C, and it is 1.05~1.15 to filter, be concentrated under reduced pressure into relative density, vacuum drying, then powder
Broken, sieving gets dry extract powder A, spare;
S2, the Poria cocos for taking corresponding parts by weight, the tuber of pinellia, Prunella vulgaris and Radix Glycyrrhizae add the ethanol water of 8 times of amounts to decoct 6h, filter, subtract
It is 1.20~1.24 that pressure, which is concentrated into relative density, flocculate with chitosan, then crush, be sieved the powder B of getting dry extract, spare;
S3, the white book for taking corresponding parts by weight, the dried immature fruit of citron orange, dried orange peel and Radix Angelicae Sinensis supercritical CO2Fluid extraction volatile oil, and will wave
Hair oil is detached with the dregs of a decoction, and the volatile oil cyclic dextrin clathrate of separation obtains volatile oil inclusion complex, spare, and phase is added in the remaining dregs of a decoction
The Radix Salviae Miltiorrhizae and entrainer for answering parts by weight carry out supercritical CO again2Fluid extraction, be concentrated under reduced pressure into again relative density be 1.15~
1.25, it is dried in vacuo, crushes, being sieved up to dried cream powder C, it is spare;
S4, dried cream powder A, dried cream powder B, dried cream powder C and volatile oil inclusion complex prepared by above-mentioned steps are uniformly mixed, and added
Add auxiliary material, then is pelletized, the encapsulated Chinese medicine composition up to treatment dizziness.
In the present invention, the size for the sieve used that is sieved in the S1 steps, S2 steps and S3 steps is 100 mesh or more;
In the S2 steps part of flocculate with chitosan be related to using asterism-effect surface method flocculates.
500 people of patients with vertigo is chosen, is divided into five groups, and patient's severity is suitable between group and group, first group of patient
Take the Chinese medicine composition of the preparation of embodiment one, second group of patient takes the Chinese medicine composition of the preparation of embodiment two, third group is suffered from
Person takes the Chinese medicine pentahapto object of the preparation of embodiment three, the 4th group of patient takes Chinese medicine composition prepared by example IV, and five groups are
Control group takes QIANGLI DINGXUAN PIAN according to routine clinical medication, carries out randomized controlled treatment, and the course for the treatment of is 1 month, must not during treatment
Simultaneously using other Chinese patent drugs for having similar effect, and the equal less salt of diet, low fat diet during treating, wine for giving off smoking, harmonizing emotions,
It strikes a proper balance between work and rest, every group of dizziness Cure is counted after 1 month, and track and record 6 months to the patient of healing, count recurrence rate,
As a result as follows:
First group | Second group | Third group | 4th group | Control group | |
Cure rate % | 86% | 82% | 82% | 84% | 67% |
Recurrence rate % | 1% | 3% | 4% | 2% | 7% |
Experimental result shows that the rate of curing the disease that patients with vertigo takes the Chinese medicine composition of the preparation of embodiment one~tetra- can reach
80% or more, it is much better than the cure rate of control group;And the recurrence rate of first group~third group is below the recurrence rate of control group, table
Bright Chinese medicine composition proposed by the present invention is good to the therapeutic effect of vertiginous disorder, and has not only taken stopgap measures but also effected a permanent cure, and recurrence rate is low.And it takes
85% or more the patient of the Chinese medicine composition prepared with embodiment one~tetra- reacts that the Chinese medicine composition taken is more daily to be taken
Traditional Chinese herbal decoction is easy to take.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (8)
1. a kind of Chinese medicine composition for treating dizziness, which is characterized in that include the raw material of following parts by weight:45~55 parts of Radix Salviae Miltiorrhizae,
18~22 parts of Poria cocos, 18~22 parts of Rhizoma Atractylodis Macrocephalae, 18~22 parts of the tuber of pinellia, 18~22 parts of dried orange peel, 18~22 parts of the dried immature fruit of citron orange, pueraria lobata 15~25
Part, 15~25 parts of rhodiola root, 25~35 parts of ginkgo leaf, 25~35 parts of radix achyranthis bidentatae, 10~20 parts of Radix Angelicae Sinensis, 12~18 parts of uncaria, summer
20~30 parts of withered grass, 18~22 parts of Cortex Eucommiae, 4~8 parts of Radix Glycyrrhizae.
2. a kind of Chinese medicine composition for treating dizziness according to claim 1, which is characterized in that including following parts by weight
Raw material:50 parts of Radix Salviae Miltiorrhizae, 20 parts of Poria cocos, 20 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of the tuber of pinellia, 20 parts of dried orange peel, 20 parts of the dried immature fruit of citron orange, 20 parts of pueraria lobata, rhodiola root 20
Part, 30 parts of ginkgo leaf, 30 parts of radix achyranthis bidentatae, 15 parts of Radix Angelicae Sinensis, 15 parts of uncaria, 25 parts of Prunella vulgaris, 20 parts of Cortex Eucommiae, 6 parts of Radix Glycyrrhizae.
3. a kind of Chinese medicine composition for treating dizziness according to claim 1, which is characterized in that the Radix Salviae Miltiorrhizae, pueraria lobata, red
Red-spotted stonecrop, ginkgo leaf, radix achyranthis bidentatae, Radix Angelicae Sinensis mass ratio be 2.25~5.5:0.75~2.5:0.75~2.5:1.25~3.5:1.25
~3.5:1.
4. a kind of Chinese medicine composition for treating dizziness according to claim 1, which is characterized in that the Chinese medicine composition
Preparation type is capsule.
5. a kind of Chinese medicine composition for treating dizziness according to claim 1-4, which is characterized in that preparation method includes
Following steps:
S1, the pueraria lobata for taking corresponding parts by weight, rhodiola root, ginkgo leaf, radix achyranthis bidentatae, uncaria and Cortex Eucommiae add the ethyl alcohol of 6~8 times of amounts to carry
It takes 1~3 time, 0.5~2h, Extracting temperature are 70~80 DEG C every time, and filtering is concentrated under reduced pressure, vacuum drying, then crushes, is sieved
Dried cream powder A, it is spare;
S2, the Poria cocos for taking corresponding parts by weight, the tuber of pinellia, Prunella vulgaris and Radix Glycyrrhizae add the ethanol water of 8~10 times of amounts to decoct 4~6h, mistake
Filter is concentrated under reduced pressure, flocculate with chitosan, then crush, be sieved the powder B of getting dry extract, spare;
S3, the white book for taking corresponding parts by weight, the dried immature fruit of citron orange, dried orange peel and Radix Angelicae Sinensis supercritical CO2Fluid extraction volatile oil, and by volatile oil
It is detached with the dregs of a decoction, the volatile oil cyclic dextrin clathrate of separation obtains volatile oil inclusion complex, spare, in the remaining dregs of a decoction plus corresponding heavy
The Radix Salviae Miltiorrhizae and entrainer for measuring part carry out supercritical CO again2Fluid extraction is concentrated under reduced pressure, is dried in vacuo, crushing, being sieved up to dry again
Cream powder C, it is spare;
S4, dried cream powder A, dried cream powder B, dried cream powder C and volatile oil inclusion complex prepared by above-mentioned steps are uniformly mixed, and added auxiliary
Material, then pelletized, the encapsulated Chinese medicine composition up to treatment dizziness.
6. a kind of Chinese medicine composition for treating dizziness according to claim 1, which is characterized in that the S1 steps, S2 steps
The size of sieve used in being sieved in rapid and S3 steps is 100 mesh or more.
7. a kind of Chinese medicine composition for treating dizziness according to claim 1, which is characterized in that depressurized in the S1 steps
The relative density of concentrate is 1.05~1.15 after concentration, and the relative density of concentrate is after being concentrated under reduced pressure in the S2 steps
1.20~1.24, the relative density of concentrate is 1.15~1.25 after being concentrated under reduced pressure in the S3 steps.
8. a kind of Chinese medicine composition for treating dizziness according to claim 1, which is characterized in that shell is poly- in the S2 steps
The flocculated part of sugar is related to using asterism-and effect surface method flocculates.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101244144A (en) * | 2008-03-03 | 2008-08-20 | 姚付山 | Chinese medicine composition for treating vertigo and method of preparing the same |
CN102283964A (en) * | 2011-09-07 | 2011-12-21 | 中国人民解放军第三七一医院 | Chinese medicinal preparation for treating vertigo |
CN103800846A (en) * | 2012-11-11 | 2014-05-21 | 郭以慧 | Traditional Chinese medicine for treating dizziness |
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2018
- 2018-07-27 CN CN201810839131.7A patent/CN108653513A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101244144A (en) * | 2008-03-03 | 2008-08-20 | 姚付山 | Chinese medicine composition for treating vertigo and method of preparing the same |
CN102283964A (en) * | 2011-09-07 | 2011-12-21 | 中国人民解放军第三七一医院 | Chinese medicinal preparation for treating vertigo |
CN103800846A (en) * | 2012-11-11 | 2014-05-21 | 郭以慧 | Traditional Chinese medicine for treating dizziness |
Non-Patent Citations (1)
Title |
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钟赣生主编: "《中药学》", 31 August 2016, 中国中医药出版社 * |
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