CN108652016B - Health-care product capsule for supplementing water and removing chloasma and production method thereof - Google Patents
Health-care product capsule for supplementing water and removing chloasma and production method thereof Download PDFInfo
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- CN108652016B CN108652016B CN201710193789.0A CN201710193789A CN108652016B CN 108652016 B CN108652016 B CN 108652016B CN 201710193789 A CN201710193789 A CN 201710193789A CN 108652016 B CN108652016 B CN 108652016B
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- sodium hyaluronate
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- removing chloasma
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- 239000002775 capsule Substances 0.000 title claims abstract description 42
- 206010008570 Chloasma Diseases 0.000 title claims abstract description 34
- 208000003351 Melanosis Diseases 0.000 title claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 17
- 230000001502 supplementing effect Effects 0.000 title claims abstract description 12
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 62
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 62
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 62
- 102000008186 Collagen Human genes 0.000 claims abstract description 22
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- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 2
- 239000001888 Peptone Substances 0.000 claims description 2
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- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims description 2
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- 229910021641 deionized water Inorganic materials 0.000 description 11
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- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 7
- 229940097043 glucuronic acid Drugs 0.000 description 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 6
- UJOBWOGCFQCDNV-UHFFFAOYSA-N 9H-carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
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- 238000002791 soaking Methods 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
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- 159000000000 sodium salts Chemical class 0.000 description 3
- 235000010339 sodium tetraborate Nutrition 0.000 description 3
- 239000004328 sodium tetraborate Substances 0.000 description 3
- FPFSGDXIBUDDKZ-UHFFFAOYSA-N 3-decyl-2-hydroxycyclopent-2-en-1-one Chemical compound CCCCCCCCCCC1=C(O)C(=O)CC1 FPFSGDXIBUDDKZ-UHFFFAOYSA-N 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
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- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- QBPFLULOKWLNNW-UHFFFAOYSA-N chrysazin Chemical compound O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O QBPFLULOKWLNNW-UHFFFAOYSA-N 0.000 description 2
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- 210000003743 erythrocyte Anatomy 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
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- 241000561734 Celosia cristata Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
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- 239000003513 alkali Substances 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
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- 239000010949 copper Substances 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
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- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- IMBKASBLAKCLEM-UHFFFAOYSA-L ferrous ammonium sulfate (anhydrous) Chemical compound [NH4+].[NH4+].[Fe+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O IMBKASBLAKCLEM-UHFFFAOYSA-L 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a health-care product capsule for supplementing water and removing chloasma and a production method thereof, wherein the method comprises the following steps of: step A: respectively pulverizing collagen, flos Rosae Rugosae, grape seed extract and starch, sieving with 80 mesh sieve to obtain corresponding fine powder; and (B) step (B): embedding sodium hyaluronate with zein to obtain microencapsulated sodium hyaluronate; step C: weighing 40-50 parts by mass of the grape seed extract crushed in the step A, 5-8 parts by mass of microencapsulated sodium hyaluronate in the step B, mixing for 10-15 min, adding 150-200 parts by mass of collagen crushed in the step A, 80-100 parts by mass of rose and 75-85 parts by mass of starch, and mixing for 30-40 min; then filling capsules according to the mass of 0.4g of each capsule. The health product capsule has remarkable effects of moisturizing skin and removing chloasma, and is safe and reliable to eat and nontoxic.
Description
Technical Field
The invention relates to a health-care product capsule for supplementing water and removing chloasma and a production method thereof.
Background
Publication number CN104431683a discloses a traditional Chinese medicine skin care health care product, which comprises rose, collagen, vitamin E, grape seed extract, sodium hyaluronate and other components, wherein the components in the patent comprise vitamin E which is orange or pale yellow oily liquid at room temperature, is dissolved in fat or fat solvent, is relatively stable to heat, acid and other environments, is unstable when meeting alkali, can be oxidized, and is easily damaged in rancid grease. The pH of the sodium hyaluronate is 6-8, the sodium hyaluronate is alkaline, the sodium hyaluronate is stable under alkaline condition and is easy to degrade under acidic condition, and the sodium hyaluronate is degraded under the action of oxygen free radicals or ultraviolet rays in the coexistence of metal ions such as iron, copper and the like and reducing agents such as ascorbic acid (vitamin C) or cysteine and the like, and the subsequent treatment of the sodium hyaluronate is not carried out in the patent, so that the moisturizing effect of the skin care health care product is affected.
The publication number CN101653256A discloses a production method of a health care product capsule for maintaining beauty and keeping young and delaying aging, wherein sodium hyaluronate is obtained from cockscomb, and at present, the avian influenza is more severe, and also some animal epidemic infectious sources are uncontrollable, so that the product is influenced necessarily.
The invention provides an ecological and environment-friendly production method of a moisturizing capsule aiming at the problem that the existing moisturizing capsule is poor in product performance.
Disclosure of Invention
The invention aims to provide a health-care product capsule for supplementing water and removing chloasma and a production method thereof.
In order to achieve the technical effects, the invention adopts the following technical scheme:
a method for producing a health product capsule for supplementing water and removing chloasma comprises the following steps:
step A: respectively pulverizing collagen, flos Rosae Rugosae, grape seed extract and starch, sieving with 80 mesh sieve to obtain corresponding fine powder;
and (B) step (B): embedding sodium hyaluronate with zein to obtain microencapsulated sodium hyaluronate;
step C: weighing 40-50 parts by mass of the grape seed extract crushed in the step A, 5-8 parts by mass of microencapsulated sodium hyaluronate in the step B, mixing for 10-15 min, adding 150-200 parts by mass of collagen crushed in the step A, 80-100 parts by mass of rose and 75-85 parts by mass of starch, and mixing for 30-40 min; and then filling capsules according to the mass of 0.4g of each capsule, thus obtaining the health-care product capsule for supplementing water and removing chloasma.
The further technical scheme is that 46 parts by mass of grape seed extract crushed in the step A and 6 parts by mass of microencapsulated sodium hyaluronate in the step B are respectively weighed and mixed for 10-15 min in the step C, and then 180 parts by mass of collagen, 90 parts by mass of rose and 78 parts by mass of starch crushed in the step A are added and mixed for 30-40 min.
The further technical proposal is that the collagen is selected from collagen with molecular weight of 1500-3000 daltons, the hydroxyproline content of the collagen is not less than 11 percent, and the protein content of the collagen is not less than 90 percent.
The further technical proposal is that the molecular weight of the sodium hyaluronate is 20 ten thousand to 40 ten thousand daltons.
The further technical scheme is that the grape seed extract is extracted by micro-boiling ethanol solution with the mass fraction of 50-70% for 2-3 times, each time for 2-3 hours, the extract is filtered while hot, and the filtrate is concentrated in vacuum and spray-dried.
The further technical scheme is that the rose is dehydrated and dried by a vacuum freeze dryer.
The preparation method of the sodium hyaluronate is characterized by taking glucose, yeast powder and peptone as culture media and fermenting streptococcus equi subspecies zooepidemicus.
The further technical proposal is that the concrete steps of embedding sodium hyaluronate by zein are as follows: dissolving zein in 85-95% ethanol solution, stirring to dissolve completely, and preparing sodium hyaluronate coating solution with mass fraction of 4-6%; sodium hyaluronate is fed into a fluidized bed in a negative pressure feeding mode, and sodium hyaluronate coating liquid is used for embedding sodium hyaluronate through a transfusion trolley and a bottom spraying gun, so that loose and uniform microencapsulated sodium hyaluronate is prepared.
The further technical proposal is that the air pressure of the bottom spray gun is 0.1-0.5kg/cm 3 The spraying frequency is 10-40HZ, the fan frequency is 25-45HZ, the air inlet temperature is 45+/-5 ℃, the air outlet temperature is 30+/-5 ℃, and the coating time is 1-2 hours.
The invention also provides the health-care product capsule for supplementing water and removing chloasma, which is obtained by the production method of the health-care product capsule for supplementing water and removing chloasma.
The invention is further explained and illustrated below.
The collagen is selected from collagen with molecular weight of 1500-3000 dalton, which is more favorable for oral absorption, has small molecular weight, poor stability, poor absorption effect due to large molecular weight, and stable property and good human absorption effect due to molecular weight of 1500-3000 dalton.
The molecular weight of the sodium hyaluronate is generally 8-400 kilodaltons, the sodium hyaluronate with the molecular weight of 20-40 kilodaltons is selected in the invention, the oral absorption is facilitated, and the performance is more stable than the sodium hyaluronate with the molecular weight of less than 20 kilodaltons.
The rose is dehydrated and dried by a vacuum freeze dryer, so that the active ingredients, color, smell and taste of the rose are kept as much as possible. The rose has the health-care functions of promoting qi circulation, promoting blood circulation, treating wind arthralgia, relieving fatigue and pain, moistening and beautifying, protecting skin and beautifying, activating blood, protecting liver, harmonizing stomach and nourishing liver.
In the mixing process, the grape seed extract and the sodium hyaluronate are mixed firstly, and the reason is that the adding amount of the sodium hyaluronate is small, so that in order to ensure that the raw materials are fully and uniformly mixed, the sodium hyaluronate and the grape seed extract with small second amount are firstly taken and uniformly mixed in an equal and incremental mode and then are mixed with other materials, so that the full and uniform mixing of all the materials is ensured.
The sodium hyaluronate is fermented by streptococcus equi subspecies zooepidemicus, so that the safety of raw materials is ensured.
The main functional components of the grape seed extract are procyanidine, procyanidine polymer and oligomer, and the oligomer procyanidine can be truly absorbed and utilized by human bodies, and the grape seed extract with the oligomer content not lower than 60 percent has stronger oxidation resistance and oxygen free radical removal capability.
In the process of developing the health-care food containing sodium hyaluronate, the sodium hyaluronate is mixed with collagen and vitamin C raw materials at one time, and the raw materials are mixed according to the formula amount and are filled into capsules, so that the result shows that the sample property is changed from white-like powder into yellow viscous semisolid in a short period of 3 months, the sodium hyaluronate content is degraded to more than 50%, and the due efficacy of the product is lost. Because sodium hyaluronate has strong hygroscopicity and easy degradation specificity, the development of ideal, stable and long-acting health-care food of sodium hyaluronate is a difficult problem to be solved by the technicians in the field.
Because sodium hyaluronate has the characteristics of hygroscopicity, easy degradation and the like, the properties of the sodium hyaluronate can be changed when the sodium hyaluronate is placed in the air for a long time or is exposed to sunlight or has higher temperature, and the conditions can be inevitably generated in the process of industrially producing oral health care products, so that the efficacy of the sodium hyaluronate can be greatly reduced by directly adding the sodium hyaluronate or the sodium hyaluronate into the health care products. The oral health food mainly comprises plant extracts with oxidation resistance factors, such as grape seed extracts, wherein the water content of the plant extracts is high, the plant extracts are generally qualified when the water content is controlled below 9%, and the plant extracts have complex components, and if the oral health food is directly matched with hyaluronic acid and sodium salt thereof, the hyaluronic acid and sodium salt thereof are extremely easy to cause the hyaluronic acid and sodium salt thereof to absorb the water content in the plant extracts or to cause degradation reaction with some components, so that the efficacy is affected. Therefore, the invention adopts the fluidized bed granulating and coating machine to send the hyaluronic acid into the fluidized bed through a negative pressure feeding mode, and then uses the adhesive to embed the hyaluronic acid powder through the transfusion trolley and the bottom spray gun, thereby thoroughly solving the problems that the hyaluronic acid is easy to absorb moisture, degrade and the like.
Corn protein is also called alcohol soluble protein, because about 90% is food protein, the corn protein has the effects of bonding, brightening, hydrophobicity, oxygen resistance, easy film formation and the like, has the property of highly resisting microbial attack, and is a green product widely applied to industries such as medicines, foods and the like. The invention adopts zein as a microencapsulation wall material to embed sodium hyaluronate.
Compared with the prior art, the invention has the following beneficial effects:
the health product capsule has obvious effects of moisturizing skin and removing chloasma, and has obvious effects of removing dark circles and bags, and the capsule is safe and reliable to eat and has no toxicity.
Detailed Description
The invention is further illustrated and described below in connection with the following examples of the invention.
Examples:
according to the dosage of 1000 (0.4 g/grain):
step A: respectively pulverizing collagen, flos Rosae Rugosae, grape seed extract and starch, sieving with 80 mesh sieve to obtain corresponding fine powder;
and (B) step (B): zein is dissolved in 90% ethanol solution and stirred to be completely dissolved, so as to prepare 5% sodium hyaluronate coating liquid. Sodium hyaluronate is fed into a fluidized bed of a DBL-3 fluidized bed granulating and coating machine in a negative pressure feeding mode, and sodium hyaluronate coating liquid is used for embedding sodium hyaluronate powder through an infusion trolley and a bottom spray gun to prepare microencapsulated sodium hyaluronate.
Step C: and D, weighing 46g of the grape seed extract crushed in the step A and 6g of microencapsulated sodium hyaluronate, mixing for 10min, then adding 180g of collagen, 90g of rose and 78g of starch crushed in the step A, mixing for 30min, and then filling capsules according to the mass of 0.4g of each capsule.
1. Sensory properties
Table 1: sensory requirements
Project | Index (I) |
Color | The content is light pink to pink |
Traits (3) | The hard capsule has complete and smooth appearance, no deformation, no rupture and no leakage; the content is powder |
Taste, smell | Has special flavor and smell, no peculiar smell, and no foreign odor |
Impurity(s) | No macroscopic foreign matter |
2. Physical and chemical properties
Table 2: physical and chemical index
3. Microorganism index
Table 3: microorganism index
4. Determination of the content of marker Components
Table 4: content determination of marker ingredient
The method for measuring sodium hyaluronate comprises the following steps:
4.1 instrument: 721 type ultraviolet visible photometer; an electronic balance.
4.2 reagents
4.2.1 borax sulfuric acid solution: 4.77g of sodium tetraborate are weighed and dissolved in 500mL of concentrated sulfuric acid.
4.2.2 carbazole test solution: carbazole 0.25g was weighed, dissolved in 200mL absolute ethanol, and stored in a brown bottle at cold place.
4.2.3 glucuronic acid control solution: precisely weighing the glucuronic acid reference substance 50mg which is dried to constant weight in vacuum at 105 ℃, placing the glucuronic acid reference substance in a100 mL volumetric flask, adding the solution to be diluted to a scale, shaking the flask evenly, and diluting the flask by 10 times to obtain the reference substance solution of 50 mug/mL.
4.2.4 sodium hydroxide solution: weighing 20.00g of sodium hydroxide, adding deionized water to a volume of 100mL, and stirring uniformly.
4.2.5 hydrochloric acid solution: weighing 50mL of hydrochloric acid, adding deionized water to a volume of 100mL, and stirring uniformly.
4.2.6 2% ferric ammonium sulfate solution: 2g of ferric ammonium sulfate is weighed, dissolved by hydrochloric acid with the concentration of 2mol/L and fixed to 100mL.
4.2.7 chromatography column: the filler is macroporous resin (model ADS-8). Pretreatment: taking 100g of ADS-8 resin, soaking the ADS-8 resin in deionized water, and pouring out the soaking solution; soaking with 2% (w/v) sodium hydroxide for 4 hr, pouring out the soaking solution, and washing with deionized water to neutrality (pH 7); then adding 5% (v/v) hydrochloric acid to soak the punching resin for 4 hours, pouring out the soaking liquid, washing the resin to be neutral (pH 7) by deionized water, filling the resin into a column, washing the resin by deionized water, wherein the dosage of the deionized water is about 2 times of the volume of the resin, and thus finishing the pretreatment of the resin.
4.3 preparation of sample solution: accurately weighing 2g of a sample calculated according to a dried product, placing the sample in a conical flask, adding 15mL of dilute hydrochloric acid solution (mixing deionized water and hydrochloric acid according to the volume ratio of 95:5), adding 5mL of 2% ammonium iron sulfate solution, uniformly mixing, placing in a boiling water bath for refluxing, accurately heating for 40min, and immediately cooling. After cooling, slowly pouring the sample liquid into a chromatographic column, after the sample is completely adsorbed, dripping and washing the conical flask by using 20mL of deionized water, pouring the dripping and washing liquid into the chromatographic column, pouring 180mL of deionized water into the chromatographic column for 9 times, washing the column until no water flows out from a water outlet below, namely collecting all effluent liquid, transferring the effluent liquid into a 250mL volumetric flask, adding deionized water for dissolving and diluting to scale, and shaking uniformly to obtain the composite material.
4.4 preparation of standard curve: precisely sucking control solution 0, 0.2, 0.4, 0.6, 0.8 and 1.0mL, placing in test tubes, adding water to 1mL respectively, shaking up and cooling to below 4deg.C, slowly adding borax sulfuric acid solution 5mL under shaking, adding into boiling water bath for 10min, taking out and cooling, precisely adding carbazole test solution 0.2mL, shaking up, heating in boiling water bath for 15min, and cooling to room temperature. The absorbance values were measured by spectrophotometry (appendix IV A of the second edition of the pharmacopoeia of the people's republic of China, 2010) at a wavelength of 530nm, and the regression equation was calculated from the mug number of glucuronic acid and the absorbance values.
4.5 sample measurement: and (3) accurately sucking 1.0mL of the sample solution, placing the sample solution in a test tube, performing normal operation from' cooling to 4 ℃ under the preparation item of a 4.3 standard curve, measuring the absorbance value, substituting the absorbance value into a regression equation, and calculating the content of the glucuronic acid.
4.6 results calculation
X 1 =(m 1 ×V×10 -6 )/(m×V 1 ×(1-X 3 ))×100%
Wherein:
X 1 -the glucuronic acid content in the sample, g/100g;
m-sample mass, g;
m 1 -calculated mass of glucuronic acid, μg;
X 3 -loss of dry,%;
v-the volume of the first constant volume of the sample, mL;
V 1 sample measurement sampling volume, mL.
Sodium hyaluronate content in sample (g/100 g) =x 1 ×2.0675
5. Safety evaluation
According to the technical Specification for testing and evaluating health food (2003 edition), the acute oral toxicity test, three genetic toxicity tests (Ames test, mice marrow multiple-infected erythrocyte micronucleus test, mice sperm malformation test) and 30-day feeding test are tested, and the test results are as follows:
5.1, acute oral toxicity test results: the acute oral MTD of the Kunming female and male mice is more than 20.00 g/kg.bw, and the Kunming female and male mice belong to non-toxic grade.
5.2, three genotoxicity test results: the Ames test, the mice marrow multiple-staining erythrocyte micronucleus test and the mice sperm malformation test result are all negative.
Feeding test results for 5.3 and 30 days: the SD rats are filled with the health care product capsules of the invention in doses of 1.0g/kg.bw, 2.0g/kg.bw and 4.0g/kg.bw for 30 days, and animals grow well during the experimental period, and the weight, the weight gain, the food utilization rate, the blood routine index, the blood biochemical index, the organ weight and the organ/weight ratio of each dose group are compared with the comparison group, and have no significant difference (P is more than 0.05). Gross anatomic and histopathological examination did not see any abnormal changes associated with the samples. The health product capsule is indicated to have no obvious toxic or side effect on rats after 30 days of feeding.
Table 5: sample mice acute oral toxicity test animal weight results
Sex (sex) | Animal number (only) | Initial weight (g) | Weekend weight (g) | Two weekends weight (g) |
Male male | 10 | 19.16±0.88 | 26.21±1.45 | 31.08±1.70 |
Female | 10 | 20.40±0.77 | 25.90±1.55 | 28.12±1.95 |
Table 6: acute toxicity test results of sample mice
Sex (sex) | Animal number (only) | Pathway | Dosage (g/kg. Bw) | Number of deaths (only) | MTD(g/kg.bw) |
Male male | 10 | Oral cavity | 20.00 | 0 | >20.00 |
Female | 10 | Oral cavity | 20.00 | 0 | >20.00 |
Table 7: ames test results (first time)
Table 8: ames test results (second time)
Positive controls ta97+s9, ta98+s9, ta100+s9 used 2-AF (dose 10.0 μg/dish); TA97-S9 and TA98-S9 were 9-snore (dose 0.2. Mu.g/dish); TA100-S9 NaN 3 (dose 1.5. Mu.g/dish); TA 102+S9 1, 8-dihydroxyanthraquinone (dose 50.0. Mu.g/dish); TA102-S9 used MMC (dose 0.5. Mu.g/dish).
6. Human body test food test detection for improving skin moisture function
According to the technical specifications for inspection and evaluation of health food (2003 edition), the health product capsule of the invention is subjected to human body test feeding test for improving skin moisture function. The test results are as follows: the voluntary subjects are randomly divided into a test food group and a control group according to skin moisture, and the test result shows that the skin moisture of the test food group is obviously improved after test food, and the difference between the test food group and the test food is significant (P < 0.05) and the difference between the test food group and the control group is significant (P < 0.05), so that the health food capsule has the function of improving skin moisture. Before and after the capsule of the health care product is tried, various detection indexes such as blood routine, blood biochemistry and the like are all in a normal range, and allergy and other adverse reactions are not observed.
Table 9: weight, blood pressure, heart rate, urine, stool and blood routine changes (average value.+ -. Standard deviation) before and after test feeding
Table 10: biochemical index change condition before and after test food
Table 11: skin test results
The skin moisture of the test group is obviously improved after test, and the difference between the skin moisture and the test group is significant (P is less than 0.05) compared with the difference between the skin moisture and the test group (P is less than 0.05).
7. Human body test feeding test with chloasma removing function
According to the technical specification of inspection and evaluation of health food (2003 edition), the health product capsule of the invention is subjected to a human body test food test with the function of removing chloasma. The test results are as follows: the subjects are randomly divided into test food combination control groups according to the color and area conditions of chloasma, and the results after 45 days show that the color integral of the test food group and the comparison difference between the test food group and the test food group before implementation and the comparison group are significant (P is less than 0.05); the area of chloasma has significance (P is less than 0.05) compared with the difference between the area of chloasma and the area of chloasma before and after the self test food and the comparison group, the area of chloasma in the test feeding group is reduced by 13.69 percent on average; the total effective rate of the test group for removing chloasma is 73.58%, compared with the control group (9.43), the difference is significant (P is less than 0.05), and no new chloasma is generated. Therefore, the health product capsule of the invention has the function of removing chloasma. Before and after the capsule of the health care product is tried, various detection indexes such as blood routine, blood biochemistry and the like are all in a normal range, and allergy and other adverse reactions are not observed.
Table 12: chloasma color change comparison (integral, mean value.+ -. Standard deviation)
Grouping | Before taking the test food | After taking the food | Difference value |
Control group | 2.60±0.36 | 2.57±0.44 | 0.07±0.24 |
Test food group | 2.58±0.35 | 2.18±0.26 | 0.41±0.20 |
Table 13: chloasma area variation comparison (mm) 2 Mean ± standard deviation
Grouping | Before taking the test food | After taking the food | Difference value | Percent reduction (%) |
Control group | 5465.1±1144.8 | 5377.4±1075.1 | 87.7±280.0 | 1.60 |
Test food group | 5470.4±1207.9 | 4721.9±838.6 | 748.7±418.4 | 13.69 |
Table 14: efficacy comparison for removing chloasma
Grouping | Number of examples | Effective and effective | Invalidation of | The total effective rate is% |
Control group | 53 | 5 | 48 | 9.43 |
Test food group | 53 | 39 | 14 | 73.58 |
Although the invention has been described herein with reference to the above-described illustrative embodiments thereof, the above-described embodiments are merely preferred embodiments of the present invention, and the embodiments of the present invention are not limited by the above-described embodiments, it should be understood that numerous other modifications and embodiments can be devised by those skilled in the art that will fall within the scope and spirit of the principles of this disclosure.
Claims (8)
1. The production method of the health product capsule for supplementing water and removing chloasma is characterized by comprising the following steps of:
step A: respectively pulverizing collagen, flos Rosae Rugosae, grape seed extract and starch, sieving with 80 mesh sieve to obtain corresponding fine powder;
and (B) step (B): embedding sodium hyaluronate with zein to obtain microencapsulated sodium hyaluronate; the specific steps of embedding sodium hyaluronate with zein are as follows: dissolving zein in 85-95% ethanol solution, stirring to dissolve completely, and preparing sodium hyaluronate coating solution with mass fraction of 4-6%; sodium hyaluronate is fed into a fluidized bed in a negative pressure feeding mode, and sodium hyaluronate coating liquid is used for embedding sodium hyaluronate through a transfusion trolley and a bottom spray gun to prepare uniformly loosened microencapsulated sodium hyaluronate; the air pressure of the bottom spraying spray gun is 0.1-0.5kg/cm 3 The spraying frequency is 10-40HZ, the fan frequency is 25-45HZ, the air inlet temperature is 45+/-5 ℃, the air outlet temperature is 30+/-5 ℃, and the coating time is 1-2 hours;
step C: weighing 40-50 parts by mass of the grape seed extract crushed in the step A, 5-8 parts by mass of microencapsulated sodium hyaluronate in the step B, mixing for 10-15 min, adding 150-200 parts by mass of collagen crushed in the step A, 80-100 parts by mass of rose and 75-85 parts by mass of starch, and mixing for 30-40 min; and then filling capsules according to the mass of 0.4g of each capsule, thus obtaining the health-care product capsule for supplementing water and removing chloasma.
2. The method for producing a health care product capsule for moisturizing and removing chloasma according to claim 1, wherein 46 parts by mass of grape seed extract crushed in the step A and 6 parts by mass of microencapsulated sodium hyaluronate in the step B are respectively weighed and mixed for 10-15 min in the step C, and then 180 parts by mass of collagen crushed in the step A, 90 parts by mass of rose and 78 parts by mass of starch are added and mixed for 30-40 min.
3. The method for producing a health care product capsule for moisturizing and removing chloasma according to claim 1, wherein the collagen is selected from collagen with molecular weight of 1500-3000 daltons, the hydroxyproline content of the collagen is not less than 11%, and the protein content of the collagen is not less than 90%.
4. The method for producing the health care product capsule for moisturizing and removing chloasma according to claim 1, wherein the molecular weight of the sodium hyaluronate is 20-40 kilodaltons.
5. The method for producing a health care product capsule for moisturizing and removing chloasma according to claim 1, wherein the extraction method of the grape seed extract is characterized in that ethanol solution with the mass fraction of 50-70% is adopted for micro-boiling extraction for 2-3 times, each time for 2-3 hours, the extract is filtered while the extract is hot, and the filtrate is concentrated in vacuum and spray-dried.
6. The method for producing the health product capsule for moisturizing and removing chloasma according to claim 1, wherein the rose is dehydrated and dried by a vacuum freeze dryer.
7. The method for producing the health care product capsule for supplementing water and removing chloasma according to claim 1, wherein the preparation method of the sodium hyaluronate is characterized in that glucose, yeast powder and peptone are used as culture mediums, and the sodium hyaluronate is fermented by streptococcus equi subspecies zooepidemicus.
8. The health-care product capsule for moisturizing and removing chloasma obtained by the production method of the health-care product capsule for moisturizing and removing chloasma according to any one of claims 1 to 7.
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Publication number | Priority date | Publication date | Assignee | Title |
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CN102885309A (en) * | 2012-10-19 | 2013-01-23 | 中科乐仁(北京)科技发展有限公司 | Chloasma removing healthcare food composite and preparation method thereof |
CN103005471A (en) * | 2013-01-10 | 2013-04-03 | 三门峡山水方正生物科技有限公司 | Healthcare capsule for improving skin moisture |
CN104622842A (en) * | 2014-12-23 | 2015-05-20 | 北京京丰制药集团有限公司 | Calcium dobesilate capsule and preparation method thereof |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101653256A (en) * | 2009-06-09 | 2010-02-24 | 厦门市丝浓食品有限公司 | Producing method of health product capsule for beautifying face and moistering lotion |
CN102885309A (en) * | 2012-10-19 | 2013-01-23 | 中科乐仁(北京)科技发展有限公司 | Chloasma removing healthcare food composite and preparation method thereof |
CN103005471A (en) * | 2013-01-10 | 2013-04-03 | 三门峡山水方正生物科技有限公司 | Healthcare capsule for improving skin moisture |
CN104622842A (en) * | 2014-12-23 | 2015-05-20 | 北京京丰制药集团有限公司 | Calcium dobesilate capsule and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
玉米朊包埋乳酸菌素的缓释作用研究;董英等;《食品科学》;20081231;第29卷(第2期);第82-85页 * |
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