CN108652016A - For moisturizing, the health product capsule of eliminating chloasma and its production method - Google Patents
For moisturizing, the health product capsule of eliminating chloasma and its production method Download PDFInfo
- Publication number
- CN108652016A CN108652016A CN201710193789.0A CN201710193789A CN108652016A CN 108652016 A CN108652016 A CN 108652016A CN 201710193789 A CN201710193789 A CN 201710193789A CN 108652016 A CN108652016 A CN 108652016A
- Authority
- CN
- China
- Prior art keywords
- sodium hyaluronate
- moisturizing
- health product
- mass parts
- production method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000002775 capsule Substances 0.000 title claims abstract description 44
- 230000036541 health Effects 0.000 title claims abstract description 38
- 208000003351 Melanosis Diseases 0.000 title claims abstract description 35
- 206010008570 Chloasma Diseases 0.000 title claims abstract description 34
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 23
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 22
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 49
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 47
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 47
- 102000008186 Collagen Human genes 0.000 claims abstract description 22
- 108010035532 Collagen Proteins 0.000 claims abstract description 22
- 229920001436 collagen Polymers 0.000 claims abstract description 22
- 235000002532 grape seed extract Nutrition 0.000 claims abstract description 18
- 229940087603 grape seed extract Drugs 0.000 claims abstract description 18
- 239000001717 vitis vinifera seed extract Substances 0.000 claims abstract description 18
- 241000220317 Rosa Species 0.000 claims abstract description 15
- 229920002472 Starch Polymers 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 10
- 239000008107 starch Substances 0.000 claims abstract description 10
- 235000019698 starch Nutrition 0.000 claims abstract description 10
- 229920002494 Zein Polymers 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 9
- 239000005019 zein Substances 0.000 claims abstract description 9
- 229940093612 zein Drugs 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 238000011049 filling Methods 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 239000011248 coating agent Substances 0.000 claims description 10
- 238000000576 coating method Methods 0.000 claims description 10
- 239000007921 spray Substances 0.000 claims description 9
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 8
- 229920002674 hyaluronan Polymers 0.000 claims description 8
- 229960003160 hyaluronic acid Drugs 0.000 claims description 8
- 238000009835 boiling Methods 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 238000001802 infusion Methods 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 2
- 239000001888 Peptone Substances 0.000 claims description 2
- 108010080698 Peptones Proteins 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims description 2
- 239000001963 growth medium Substances 0.000 claims description 2
- 229960002591 hydroxyproline Drugs 0.000 claims description 2
- 235000019319 peptone Nutrition 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 13
- 231100000252 nontoxic Toxicity 0.000 abstract description 3
- 230000003000 nontoxic effect Effects 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 238000012360 testing method Methods 0.000 description 15
- 239000000523 sample Substances 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000008367 deionised water Substances 0.000 description 9
- 229910021641 deionized water Inorganic materials 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 7
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 7
- 229940097043 glucuronic acid Drugs 0.000 description 7
- UJOBWOGCFQCDNV-UHFFFAOYSA-N 9H-carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 235000013402 health food Nutrition 0.000 description 6
- 239000011347 resin Substances 0.000 description 6
- 229920005989 resin Polymers 0.000 description 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 5
- 235000019441 ethanol Nutrition 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 241000607142 Salmonella Species 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 231100000460 acute oral toxicity Toxicity 0.000 description 3
- 229910021538 borax Inorganic materials 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000002906 microbiologic effect Effects 0.000 description 3
- 239000000419 plant extract Substances 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000004215 skin function Effects 0.000 description 3
- 235000010339 sodium tetraborate Nutrition 0.000 description 3
- 239000004328 sodium tetraborate Substances 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- XGGLLRJQCZROSE-UHFFFAOYSA-K ammonium iron(iii) sulfate Chemical compound [NH4+].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O XGGLLRJQCZROSE-UHFFFAOYSA-K 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000561734 Celosia cristata Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- 229930184591 Fringelite Natural products 0.000 description 1
- 206010034719 Personality change Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
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- 230000000996 additive effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 206010064097 avian influenza Diseases 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 210000001520 comb Anatomy 0.000 description 1
- 229920002770 condensed tannin Polymers 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 235000021245 dietary protein Nutrition 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 125000005909 ethyl alcohol group Chemical group 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000007674 genetic toxicity Effects 0.000 description 1
- 231100000025 genetic toxicology Toxicity 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- -1 oxygen radical Chemical class 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000003359 percent control normalization Methods 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
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- 230000001681 protective effect Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
It being used for moisturizing, the health product capsule of eliminating chloasma and its production method the invention discloses a kind of, the method to include the following steps：Step A：Collagen, rose, grape seed extract, starch are smashed it through 80 mesh respectively to sieve to obtain corresponding fine powder, it is spare；Step B：Microencapsulation Sodium Hyaluronate is obtained with zein embedding Sodium Hyaluronate；Step C：40~50 mass parts of grape seed extract after step A is crushed, 5~8 mass parts of microencapsulation Sodium Hyaluronate mixing, 10~15min in step B are weighed respectively, then 150~200 mass parts of collagen after step A is crushed, 80~100 mass parts of rose, 75~85 mass parts of starch are added, mix 30~40min；It is the filling capsules of 0.4g then according to every capsule quality.The health product capsule of the present invention has significant effect to skin moisture-keeping, eliminating chloasma, and edible safety is reliable, non-toxic.
Description
Technical field
It being used for moisturizing, the health product capsule of eliminating chloasma and its production method the present invention relates to a kind of.
Background technology
Publication number CN104431683A discloses a kind of Chinese medicinal skin care health products, which includes rose, glue
The components such as former albumen, vitamin E, grape seed extract, Sodium Hyaluronate in component include vitamin E in the patent, dimension life
Plain E is at room temperature orange-yellow or pale yellow oily liquid, is dissolved in fat or fatsolvent, more stable to environment such as heat, acid, is met
Alkali is unstable, can aoxidize, and is easily destroyed in rancid grease.Sodium Hyaluronate pH is 6~8, meta-alkalescence, in alkaline item
Stablize under part, it is degradable in acid condition, in the metal ions such as iron, copper and ascorbic acid (vitamin C) or cysteine etc.
Reducing agent coexists down, degrades through oxygen radical or action of ultraviolet radiation, and after not carried out to Sodium Hyaluronate in the patent
Continuous processing, therefore the moisturizing effect of skin-protection health products can be influenced.
Publication No. CN101653256A discloses a kind of production for beautifying face and moistering lotion, the health product capsule of anti-aging
Method, Sodium Hyaluronate therein are obtained from cockscomb, and bird flu is more severe at present, and also some animal epidemics infect
Source is uncontrollable, will necessarily be impacted to product.
The properties of product that the present invention is directed in existing beautifying face and moistering lotion moisturizing capsule are bad, provide a kind of benefit of ecological, environmental protective
Capsule with diuresis promoting function production method.
Invention content
It being used for moisturizing, the health product capsule of eliminating chloasma and its production method the object of the present invention is to provide a kind of.
In order to reach above-mentioned technique effect, the present invention takes following technical scheme：
It is a kind of for moisturizing, eliminating chloasma health product capsule production method, include the following steps：
Step A：Collagen, rose, grape seed extract, starch are smashed it through 80 mesh respectively to sieve to obtain accordingly
Fine powder, it is spare；
Step B：Microencapsulation Sodium Hyaluronate is obtained with zein embedding Sodium Hyaluronate；
Step C：Weigh that 40~50 mass parts of grape seed extract after step A is crushed, microencapsulation is transparent in step B respectively
5~8 mass parts of matter acid sodium mix 10~15min, and 150~200 mass parts of collagen after step A is crushed, rose is then added
It is rare to spend 80~100 mass parts, 75~85 mass parts of starch, mix 30~40min；It is filled for 0.4g then according to every capsule quality
It is encapsulated to get to described for moisturizing, the health product capsule of eliminating chloasma.
Further technical solution be weighed respectively in step C 46 mass parts of grape seed extract after step A is crushed,
6 mass parts of microencapsulation Sodium Hyaluronate mix 10~15min in step B, and the collagen 180 after step A is crushed then is added
Mass parts, 90 mass parts of rose, 78 mass parts of starch mix 30~40min.
Further technical solution is that the collagen is selected from the collagen egg that molecular weight is 1500~3000 dalton
In vain, the hydroxyproline content of collagen is not less than 11%, and the protein content of collagen is not less than 90%.
Further technical solution is that the molecular weight of the Sodium Hyaluronate is 200,000~400,000 dalton.
Further technical solution is, the extracting method of the grape seed extract be use mass fraction for 50~
70% ethanol solution slightly boiling extracts 2~3 times, and 2~3 hours, extracting solution filter while hot every time, and filtered fluid is concentrated in vacuo and spray
Mist is dried.
Further technical solution is that the rose is dehydrated using vacuum freeze drier.
Further technical solution is that the preparation method of the Sodium Hyaluronate is with glucose, yeast powder, peptone
For culture medium, fermented by Malian drainage.
Further technical solution is as follows with zein embedding Sodium Hyaluronate：Zein is dissolved in
In 85~95% ethanol solution, stirring is allowed to be completely dissolved, and the Sodium Hyaluronate coating solution that mass fraction is 4~6% is made；
Sodium Hyaluronate is sent by way of negative pressure feeding in fluid bed, spray gun is sprayed by Sodium Hyaluronate by infusion trolley and bottom
Coating solution carries out embedding treatment to Sodium Hyaluronate, and loose uniform microencapsulation Sodium Hyaluronate is made.
Further technical solution is that it is 0.1-0.5kg/cm that spray gun air pressure is sprayed at the bottom3, hydrojet frequency is 10-
40HZ, wind turbine frequency are 25-45HZ, and inlet air temperature is that 45 DEG C of ± 5 DEG C of leaving air temps are 30 DEG C ± 5 DEG C, and Coating times are 1~2
Hour.
The present invention also provides the use obtained for the production method of moisturizing, the health product capsule of eliminating chloasma
In moisturizing, the health product capsule of eliminating chloasma.
The present invention will be further explained below.
Collagen is selected from the collagen that molecular weight is 1500~3000 dalton, more conducively oral absorption, molecular weight
Too small stability is poor, and the big assimilation effect of molecular weight is poor, and the collagen property of 1500-3000 Dalton molecular weights stabilization and people
Body good absorption effect.
The molecular weight of Sodium Hyaluronate is generally 80,000~4,000,000 dalton, and what is selected in the present invention be molecular weight is 200,000
The Sodium Hyaluronate of~40 ten thousand dalton is conducive to oral absorption, and performance is less than the hyaluronic acid of 200,000 dalton compared with molecular weight
Sodium is more stable.
Rose is dehydrated using vacuum freeze drier, and active constituent and the color for retaining rose as far as possible are fragrant
Taste.Rose has sharp gas, promoting circulation of blood, controls wandering arthritis, and relieve fatigue and ease pain moistens beauty treatment, improves looks, promoting blood circulation, and liver and stomach is protected to support
The healthcare function of liver.
In mixed process, grape seed extract and Sodium Hyaluronate first mix, the reason for this is that Sodium Hyaluronate additive amount
Few, in order to ensure that raw material is sufficiently mixed uniformly, therefore the grape seed extract for first taking Sodium Hyaluronate few with the second amount is passed with equivalent
The mode of increasing is mixed with unclassified stores again after mixing, to ensure that all materials are sufficiently mixed uniformly.
Sodium Hyaluronate ensure that the safety of raw material using being fermented by Malian drainage.
The main composition of grape seed extract is procyanidine, and procyanidine is divided into polymer and oligomer, very
What can just be absorbed and utilized by the body is oligomeric proanthocyanidins, and the present invention is not less than 60% Portugal using oligomer content
Grape seed extract, anti-oxidant and scavenging activated oxygen ability are stronger.
During researching and developing the health food containing Sodium Hyaluronate, once by Sodium Hyaluronate and collagen, vitamin C
Capsule is made by formula ratio mixing, filling, as a result, it has been found that sample property is by off-white color in short 3 months in material combination
Powder turns yellow thick semisolid shape, and hyaluronic acid sodium content is degraded up to 50% or more, and the effect of product should have is lost.By
The particularity for having stronger hygroscopicity in Sodium Hyaluronate, being easy degradation develops ideal, stable, the long-acting guarantor of Sodium Hyaluronate
Health food is those skilled in the art's problem anxious to be resolved.
Since Sodium Hyaluronate has the particularity such as hygroscopicity, easy degradation, sunlight is placed or encountered for a long time in air
Irradiation or temperature all can make its character change when higher, and during industrialized production Orally taken health article, unavoidably
Ground will appear the above situation, and therefore, addition hyaluronic acid or Sodium Hyaluronate can substantially reduce its work(directly in health products
Effect.And nti-freckle health food is taken orally mostly based on the plant extracts with the inoxidizability factor, such as grape seed extract, plant
Object extract water content is high, and qualified and plant extracts complicated component is calculated in general moisture control below 9%, if directly with it is transparent
Matter acid and its sodium salt compatibility easily cause hyaluronic acid and its sodium salt to absorb the moisture in plant extracts or distribute with some groups
Raw degradation reaction is to influence effect.For this purpose, the present invention is first passed through hyaluronic acid in negative pressure using fluidized bed granulation seed-coating machine
The mode of material is sent into fluid bed, then sprays spray gun by infusion trolley and bottom and carry out hyaluronic acid powder at embedding with adhesive
Reason, to thoroughly solve the problems such as the easy moisture absorption of hyaluronic acid, degradable.
Zein is also known as alcohol soluble protein, because 90% or so be food proteins, with more it is cohesives, bright, hydrophobic, hinder oxygen and easy
Film forming and other effects, and be the green production for being widely used in the industries such as medicine, food with the performance of height resistance microbiological attack
Product.The present invention uses corn protein to be embedded to Sodium Hyaluronate for microencapsulation wall material.
Compared with prior art, the present invention having advantageous effect below：
The health product capsule of the present invention has significant effect to skin moisture-keeping, eliminating chloasma, and to removing livid ring around eye
It is had obvious effects on pouch, edible safety is reliable, non-toxic.
Specific implementation mode
With reference to the embodiment of the present invention, the invention will be further elaborated.
Embodiment：
According to the dosage of production 1000 (0.4g/)：
Step A：Collagen, rose, grape seed extract, starch are smashed it through 80 mesh respectively to sieve to obtain accordingly
Fine powder, it is spare；
Step B：Zein is dissolved in 90% ethanol solution, stirring is allowed to be completely dissolved, and 5% hyaluronic acid is made
Sodium coating solution.Sodium Hyaluronate is sent by way of negative pressure feeding in the fluid bed of DBL-3 type fluidized bed granulation seed-coating machines,
Spray gun being sprayed by infusion trolley and bottom, Sodium Hyaluronate coating solution being subjected to embedding treatment to Hyal powder, micro-capsule is made
Change Sodium Hyaluronate.
Step C：The grape seed extract 46g after step A is crushed, the 6g mixing of microencapsulation Sodium Hyaluronate are weighed respectively
Then 10min is added the collagen 180g after step A is crushed, rose 90g, starch 78g, mixes 30min, then according to
Every capsule quality is the filling capsules of 0.4g.
1, organoleptic properties
Table 1：Organoleptic requirements
| Project | Index |
| Color and luster | Content is in lightpink to pink colour |
| Character | Hard capsule, complete appearance is bright and clean, no deformation, crack-free, ne-leakage；Content is powder |
| Flavour, smell | Have the distinctive flavour of this product, a smell, free from extraneous odour, without foreign odor |
| Impurity | The exogenous impurity being visible by naked eyes |
2, physicochemical property
Table 2：Physical and chemical index
3, microbiological indicator
Table 3：Microbiological indicator
4, marker component content measures
Table 4：Significant component content measures
The assay method of Sodium Hyaluronate is as follows：
4.1 instrument：721 type ultraviolet-visible photometers；Electronic balance.
4.2 reagent
4.2.1 borax sulfuric acid solution：Sodium tetraborate 4.77g is weighed, is dissolved in the 500mL concentrated sulfuric acids.
4.2.2 carbazole test solution：Carbazole 0.25g is weighed, is dissolved in 200mL absolute ethyl alcohols, cold place in brown bottle is placed in and preserves.
4.2.3 glucuronic acid reference substance solution：Precision weighs the glucuronic acid pair for being dried under vacuum to constant weight through 105 DEG C
It according to product 50mg, is placed in 100mL volumetric flasks, in addition dissolved dilution shakes up to scale, is diluting 10 times of pairs up to 50 μ g/mL
According to product solution.
4.2.4 sodium hydroxide solution：Sodium hydroxide 20.00g is weighed, deionized water is added to be settled in 100mL capacity, is stirred
Uniformly.
4.2.5 hydrochloric acid solution：Hydrochloric acid 50mL is weighed, adds deionized water to be settled in 100mL capacity, stirs evenly.
4.2.6 2% ammonium ferric sulfate solution：Ammonium ferric sulfate 2g is weighed, with a concentration of 2mol/L dissolving with hydrochloric acid and is settled to
100mL。
4.2.7 chromatographic column：Filler is macroreticular resin (model ADS-8).Pre-treatment：Take ADS-8 resin 100g, spend from
Sub- water impregnates, and pours out soak；Again with 2% (w/v) soaking with sodium hydroxide 4h, soak is poured out, deionized water is used in combination to be washed to
Neutral (pH7)；The salt acid soak punching resin 4h for adding 5% (v/v), pours out soak, in being used in combination deionized water to be washed to
Property (pH7), fills column by resin, deionized water is used in combination to wash, deionized water dosage is about 2 times of resin volume, that is, completes resin
Pre-treatment.
The preparation of 4.3 sample solutions：Precision weighs the sample 2g calculated by dry product in conical flask, and the dilute salt of 15mL is added
Deionized water and hydrochloric acid (are pressed 95 by acid solution:5 volume ratio mixing), the 2% ammonium sulfate ferrous solution of 5mL is added, mixing is set
Boiling water bath flows back, cooling in cooling down immediately after accurate heating 40min.After cooling, sample liquid is slowly poured into chromatographic column, is waited for
After the absorption completely of all product, then with 20mL deionized water drip wash conical flasks, drip wash liquid is also poured into chromatographic column, then take 180mL go from
Sub- moisture, which is poured into chromatographic column for 9 times, washes column, until the anhydrous outflow again of lower section water outlet, that is, collect all effluxes, goes to 250mL appearances
In measuring bottle, deionized water dissolving is added to be diluted to scale, shake up to get.
The preparation of 4.4 standard curves：Precision draws control liquor 0,0.2,0.4,0.6,0.8,1.0mL, is placed in test tube
In, 1mL is respectively added water to, the concentration of corresponding glucuronic acid is respectively 0,10,20,30,40,50 (μ g/mL), shakes up and is cooled to
4 DEG C hereinafter, be slowly added to borax sulfuric acid solution 5mL under shaking, set and 10min are added in boiling water bath, and cooling is taken out, and precision is added
Carbazole test solution 0.2mL, shakes up, sets and heat 15min in boiling water bath, set and heat 15min in boiling water bath, be cooled to room temperature.According to light splitting
Photometry (《Pharmacopoeia of People's Republic of China》The two annex IV A of version in 2010) at 530nm wavelength, absorbance is measured respectively
Value calculates regression equation with the μ g numbers and absorbance value of glucuronic acid.
4.5 samples measure：Precision pipette samples solution 1.0mL, is placed in test tube, by the preparation of 4.3 standard curves
It is lower to be operated in accordance with the law from " being cooled to 4 DEG C ", absorption photometric value is measured, regression equation is substituted into, calculates containing for glucuronic acid
Amount.
4.6 results calculate
X1=(m1×V×10-6)/(m×V1×(1-X3)) × 100%
In formula：
X1The content of glucuronic acid, g/100g in-sample；
M-sample quality, g；
m1The quality of-calculated glucuronic acid, μ g；
X3- loss on drying, %；
The volume of V-sample first time constant volume, mL；
V1- sample measures sample volume, mL.
Hyaluronic acid sodium content (g/100g)=X in sample1×2.0675
5, safety evaluatio
According to《Health food is examined and assessment technique specification》(version in 2003), to acute oral toxicity test, three something lost
It passes toxicity test (Salmonella reversion test, mice bone marrow micronucleus and mouse inbred strain), feed within 30 days
Experiment is tested, and testing result is as follows：
5.1, acute oral toxicity test result：The acute oral MTD of female to Kunming kind, male mouse is all higher than 20.00g/
Kgbw belongs to nontoxic grade.
5.2, three genetic toxicity test results：Salmonella reversion test, mice bone marrow micronucleus, mouse essence
Sub- deformity test result is feminine gender.
5.3,30 days feeding trial results：With the present invention's of 1.0g/kg.bw, 2.0g/kg.bw, 4.0g/kg.bw dosage
Health product capsule was to SD rat oral gavages 30 days, and during experiment, animal growth is good, each dosage group weight, weightening, food profit
Compared with the control group with rate, routine blood indexes, blood biochemistry index, organ weights and internal organs/weight ratio, there was no significant difference (P
>0.05).Gross anatomy and tissue pathology checking have no abnormal change related with sample.The health product capsule is prompted to feed for 30 days
It supports and obvious toxic-side effects is had no to rat.
Table 5：Sample chmice acute Oral toxicity experimental animal weight result
| Gender | Number of animals (only) | Initial weight (g) | One weekend weight (g) | Two weekends weight (g) |
| It is male | 10 | 19.16±0.88 | 26.21±1.45 | 31.08±1.70 |
| It is female | 10 | 20.40±0.77 | 25.90±1.55 | 28.12±1.95 |
Table 6：Sample acute toxicity test in mice result
| Gender | Number of animals (only) | Approach | Dosage (g/kg.bw) | Death toll (only) | MTD(g/kg.bw) |
| It is male | 10 | Orally | 20.00 | 0 | ＞ 20.00 |
| It is female | 10 | Orally | 20.00 | 0 | ＞ 20.00 |
Table 7：Salmonella reversion test result (first time)
Table 8：Salmonella reversion test result (for the second time)
Positive control TA97+S9, TA98+S9, TA100+S9 use 2-AF (10.0 μ g/ wares of dosage)；TA97-S9、TA98-
S9 is intoxicated (0.2 μ g/ wares of dosage) using 9- medicines；TA100-S9 uses NaN3(1.5 μ g/ wares of dosage)；TA 102+S9 use 1,8- bis-
Fringelite (50.0 μ g/ wares of dosage)；TA102-S9 uses MMC (0.5 μ g/ wares of dosage).
6, improve the human feeding trial detection of moisture of skin function
According to《Health food is examined and assessment technique specification》(version in 2003) changes the health product capsule of the present invention
Kind moisture of skin function human feeding trial.Conclusion (of pressure testing) is as follows：Volunteer is randomly divided into according to moisture of skin situation
Test-meal group and control group, respectively eat the present invention health product capsule or placebo, after experiment the result shows that, test-meal group skin water
It point is significantly improved after test-meal, and has comparing difference significant (P ＜ 0.05) before test-meal, difference has significantly compared with the control group
Property (P ＜ 0.05), therefore the health product capsule of the present invention have improve moisture of skin function.The health care of the test-meal present invention
Before and after product capsule, the items Testing index such as blood routine, blood biochemistry does not observe allergy yet and other is bad in normal range (NR)
Reaction.
Table 9：Weight, blood pressure, heart rate, urine, stool, blood routine situation of change (mean+SD) before and after test-meal
Table 10：Changes of biochemical indexes situation before and after test-meal
Table 11：Skin detection result
The moisture of skin of test-meal group significantly improves after test-meal, significant (P ＜ 0.05) with comparing difference before and after test-meal,
Difference is significant (P ＜ 0.05) compared with the control group.
7, chloasma-dispelling function human feeding trial
According to《Health food is examined and assessment technique specification》(version in 2003) dispels to the health product capsule of the present invention
Chloasma function human feeding trial.Test result is as follows：Subject is randomly divided into test-meal group by chloasma color, area situation
Close control group, the health product capsule or placebo of the edible present invention respectively, after 45 days the result shows that, test-meal group chloasma color
Before integral is implemented with itself and control group comparing difference is significant (P ＜ 0.05)；Before and after area of chloasma and itself test-meal
And control group comparing difference is significant (P ＜ 0.05), test-meal group area of chloasma averagely reduces 13.69%；Test-meal group is dispelled
Chloasma total effective rate is 73.58%, and compared with control group (9.43), difference is significant (P ＜ 0.05), and without new yellowish-brown
Spot generates.Therefore the health product capsule of the present invention has chloasma-dispelling function effect.Before the health product capsule of the test-meal present invention
Afterwards, every Testing index such as blood routine, blood biochemistry does not observe allergy and other adverse reactions in normal range (NR) yet.
Table 12：Chloasma color change compares (integral, mean+SD)
| Grouping | Before test-meal | After test-meal | Difference |
| Control group | 2.60±0.36 | 2.57±0.44 | 0.07±0.24 |
| Test-meal group | 2.58±0.35 | 2.18±0.26 | 0.41±0.20 |
Table 13：(mm is compared in area of chloasma variation2, mean+SD)
| Grouping | Before test-meal | After test-meal | Difference | Reduce percentage (%) |
| Control group | 5465.1±1144.8 | 5377.4±1075.1 | 87.7±280.0 | 1.60 |
| Test-meal group | 5470.4±1207.9 | 4721.9±838.6 | 748.7±418.4 | 13.69 |
Table 14：Functions of removing chloasma effect compares
| Grouping | Number of cases | Effectively | In vain | Total effective rate % |
| Control group | 53 | 5 | 48 | 9.43 |
| Test-meal group | 53 | 39 | 14 | 73.58 |
Although reference be made herein to invention has been described for explanatory embodiment of the invention, and above-described embodiment is only this hair
Bright preferable embodiment, embodiment of the present invention are not limited by the above embodiments, it should be appreciated that people in the art
Member can be designed that a lot of other modification and implementations, these modifications and implementations will be fallen in principle disclosed in the present application
Within scope and spirit.
Claims (10)
1. a kind of for moisturizing, the production method of the health product capsule of eliminating chloasma, it is characterised in that include the following steps：
Step A：Collagen, rose, grape seed extract, starch are smashed it through 80 mesh respectively to sieve to obtain accordingly carefully
Powder, it is spare；
Step B：Microencapsulation Sodium Hyaluronate is obtained with zein embedding Sodium Hyaluronate；
Step C：40~50 mass parts of grape seed extract after step A is crushed, microencapsulation hyaluronic acid in step B are weighed respectively
5~8 mass parts of sodium mix 10~15min, and 150~200 mass parts of collagen after step A is crushed, rose is then added
80~100 mass parts, 75~85 mass parts of starch mix 30~40min；It is the filling glue of 0.4g then according to every capsule quality
Capsule to get to described for moisturizing, the health product capsule of eliminating chloasma.
2. according to claim 1 for moisturizing, the production method of the health product capsule of eliminating chloasma, it is characterised in that
46 mass parts of grape seed extract after step A is crushed, 6 mass of microencapsulation Sodium Hyaluronate in step B are weighed in step C respectively
Then 180 mass parts of collagen after step A is crushed, 90 mass parts of rose, starch 78 is added in part 10~15min of mixing
Mass parts mix 30~40min.
3. according to claim 1 for moisturizing, the production method of the health product capsule of eliminating chloasma, it is characterised in that
The collagen is selected from the collagen that molecular weight is 1500~3000 dalton, and the hydroxyproline content of collagen is not
Less than 11%, the protein content of collagen is not less than 90%.
4. according to claim 1 for moisturizing, the production method of the health product capsule of eliminating chloasma, it is characterised in that
The molecular weight of the Sodium Hyaluronate is 200,000~400,000 dalton.
5. according to claim 1 for moisturizing, the production method of the health product capsule of eliminating chloasma, it is characterised in that
The extracting method of the grape seed extract is that mass fraction is used to be extracted 2~3 times for 50~70% ethanol solution slightly boiling,
2~3 hours, extracting solution filter while hot every time, and filtered fluid is concentrated in vacuo and spray drying.
6. according to claim 1 for moisturizing, the production method of the health product capsule of eliminating chloasma, it is characterised in that
The rose is dehydrated using vacuum freeze drier.
7. according to claim 1 for moisturizing, the production method of the health product capsule of eliminating chloasma, it is characterised in that
The preparation method of the Sodium Hyaluronate is using glucose, yeast powder, peptone as culture medium, by Malian drainage
It ferments.
8. according to claim 1 for moisturizing, the production method of the health product capsule of eliminating chloasma, it is characterised in that
It is as follows with zein embedding Sodium Hyaluronate：Zein is dissolved in 85~95% ethanol solution, stirring makes
Be completely dissolved, be made mass fraction be 4~6% Sodium Hyaluronate coating solution；Sodium Hyaluronate is passed through into negative pressure feeding
Mode is sent into fluid bed, and spraying spray gun by infusion trolley and bottom embeds Sodium Hyaluronate Sodium Hyaluronate coating solution
Loose uniform microencapsulation Sodium Hyaluronate is made in processing.
9. according to claim 8 for moisturizing, the production method of the health product capsule of eliminating chloasma, it is characterised in that
The bottom spray spray gun air pressure is 0.1-0.5kg/cm3, hydrojet frequency is 10-40HZ, and wind turbine frequency is 25-45HZ, into wind-warm syndrome
It is 30 DEG C ± 5 DEG C that degree, which is 45 DEG C of ± 5 DEG C of leaving air temps, and Coating times are 1~2 hour.
10. the production method according to claim 1-9 any one of them for moisturizing, the health product capsule of eliminating chloasma obtains
For moisturizing, eliminating chloasma health product capsule.
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Cited By (1)
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