CN108635572A - It is a kind of to treat otitis and the auristilla and preparation method thereof for ear function of feeling well with clear ear - Google Patents

It is a kind of to treat otitis and the auristilla and preparation method thereof for ear function of feeling well with clear ear Download PDF

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Publication number
CN108635572A
CN108635572A CN201810853764.3A CN201810853764A CN108635572A CN 108635572 A CN108635572 A CN 108635572A CN 201810853764 A CN201810853764 A CN 201810853764A CN 108635572 A CN108635572 A CN 108635572A
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China
Prior art keywords
ear
specifically
auristilla
sodium
extract
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CN201810853764.3A
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赵永亮
王卫国
王冠轶
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Zhengzhou Bio Engineering Co Ltd
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Zhengzhou Bio Engineering Co Ltd
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Priority to CN201810853764.3A priority Critical patent/CN108635572A/en
Publication of CN108635572A publication Critical patent/CN108635572A/en
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
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Abstract

The invention belongs to otopathy treatment and ear health care technology fields, and in particular to a kind of to treat otitis and the auristilla and its preparation method of ear function of feeling well with clear ear.The auristilla includes the naturally required agent of anti-inflammatory bacteriostatic agent, cell physiological function regulator, protective agent, agonist, promoting blood circulation and removing obstruction in channels dose, intelligence hardening agent, antioxidant and growth metabolism, and natural anti-inflammatory bacteriostatic agent is made of extracts such as Nantural non-toxic Chinese herbal medicine alcohol extract and honeysuckles；Cell physiological function regulator is made of vitamins and coenzyme substance；Protective agent includes trehalose, allantoin；Agonist includes ATP, cromoci；Promoting blood circulation and removing obstruction in channels dose including Notogineng Extract etc.；Cell normal growth metabolism must agent include amino acids, lactic acid class and inositol.The application is had one's ideas straightened out by tool antibacterial anti-inflammatory, clearing heat and detoxicating, promoting blood circulation and removing blood stasis, dispelling wind, is removed necrosis and promoted granulation, the various ingredients of anti-inflammatory anti-anaphylaxis, nutrition skin effect are made, and is had treatment otitis, ear itching, otalgia, tinnitus, maintenance ear brain and is made the pleasant multiple efficacies of ear brain.

Description

It is a kind of to treat otitis and the auristilla and preparation method thereof for ear function of feeling well with clear ear
Technical field
The invention belongs to ENT diseases（Otopathy）Treatment and ear health care technology field, and in particular to a kind of to treat otitis And the auristilla and preparation method thereof for ear function of feeling well with clear ear.
Background technology
Ear is one of the vitals of human body, according to tcm theory, the seven apertures that ears behaviour weight is wanted（Knowledge mouth and nose） Two, and be directly connected with mouth and nose and brain.So ear diseases can not only injure ear organ itself, if cannot rationally or Treatment in time, can also involve other organs, generate even more serious consequence.Ear is not only important hearing organ and ancients One of the important channel of body and rehabilitation physical efficiency is improved, so, the quality of ear organ directly decides the health status of human body.
It is exactly otitis in addition to Hiccough and deaf in most common ear diseases.So-called otitis refers to just the inflammation that ear occurs, It medically usually can exceptionally two kinds of otitis and tympanitis.Otitis externa refers to the inflammation of external auditory canal.Otitis externa can be divided into two classes, and one Class is circumscribed external otitis, also known as furuncle of external auditory canal；The another kind of diffusivity inflammation for skin of external auditory canal, also known as diffusivity external ear Road is scorching.Tympanitis is to involve middle ear（Including Eustachian tube, tympanum tympanic antrum and mastoid air cell etc.）The inflammatory disease of all or part of structure Become, the overwhelming majority is nonspecific inflammation, can be divided into apyetous and suppurative two major classes.Apyetous includes secretory middle ear Scorching, barotraumatic otitis media；Suppurative person is divided into acute and chronic.Due to environmental factor and self reason, people is added Lack effectively ear's hygienic measures and consciousness, otitis externa and acute and chronic, otitis media suppurative have become ear-nose-throat department outpatient service Common disease and frequently-occurring disease.Naval, air arm, coastal fisherman and swimming fan easily suffer from ear disease, are occupied especially with juvenile More, adult is also very common.Though what serious disease is otitis be not, can often influence the work and life of patient, if be not treated in time or Malpractice can also result in tinnitus or deafness or the tympanic membrane perforation and cause Hearing or forfeiture, or be infected brain etc. Other tissues cause the outer complication of serious encephalic and jeopardize the life security of patient.
Since the diversity and complexity of the otitis cause of disease, such as external auditory canal water inlet and flu, pharyngitis, laryngitis can lead to ear Inflammation, otitis are more than caused by simple aerobic bacteria or anaerobic infection, are likely to mixed infection or other in many cases Reason, along with the complexity and its compactness contacted with the other vitals of body of ear organ structure, so otitis is not only It is multiple, and be also difficult to treat.Currently, the method for reply otitis mainly has both at home and abroad：Doctor trained in Western medicine medication and TCM Therapy.Mesh The preceding Western medicine for clinically being used to treat otitis includes mainly xacin-series antimicrobial, antibiotic and glucocorticoid medicine etc., agent Type mainly has oral or injection and external preparation, and due to the extensive use of antibacterials, antibody-resistant bacterium increases, and causes chemistry anti- The drug effect of bacterium drug is substantially reduced or fails, and has many antibiotic such as aminoglycoside antibiotics to also have different degrees of ear poison Property, direct toxic effect is generated to inner ear, damages cochlea, hearing is influenced, some patients is caused drug-induced deafness or tinnitus occur； A variety of serious toxic side effects of hormone medicine more allow people not go to select unless it is absolutely necessary certainly；And external Chinese medicament is more It for scattered, cream, finish, is difficult to eliminate in addition to patient is also easy to produce earwax after, influences hearing, so that clinical application is restricted outer, Also mostly containing to human body, there may be the Chinese medicines of toxic side effect or western medicine composition in its prescription；Oral or injection Chinese and Western medicine generates The harmfulness of toxic side effect then bigger.Certainly, otitis especially tympanitis is tackled, also a kind of therapy is exactly to perform the operation to control It treats, because otitis is mostly infectious diseases, in addition the uniqueness and complexity of ear structure, operative effect ideal may not be said, wind Dangerous is also that general patient is unwilling to receive.Though said medicine or therapy have certain therapeutic effect to otitis patient, treat Effect and safety it is ideal there is not been reported, even if some cure rates are higher, but because of its potential toxic side effect or harmfulness, Otitis may be cured, but deaf or tinnitus, Hearing or produce other serious toxic side effects, and patient is allowed to obtain Mistake is not repaid, is regretted to the very end of one's life.
In addition, according to the theory of motherland's medicine " sage preventive treatment of disease not treating the disease affected ", otitis is treated, the early ratio that prevents gets sick again It goes to treat even more important.With advances in technology and the improvement of people's living standards, the health care consciousness of people is more and more stronger, various The skin care item and health products of various kinds are also more and more, such as content in freckle cream, eye cream, lipstick, nose patch, but ear health care（With）Product are also rare It reports and emerges, therefore, design, a kind of otitis that is directed to of exploitation has good prevention and treatment and has the refreshing ear function of clear ear And be used conveniently and safely, to ear brain again the auristilla product with certain health care functions with highly important social value and Application prospect.
Invention content
The application be designed to provide it is a kind of treat otitis and with clear ear feel well ear function auristilla and preparation method thereof, The auristilla has significant therapeutic effect for otitis, there is antibacterial anti-inflammatory, clear ear to feel well ear, sterilizing and itch-relieving is promoting blood circulation and removing obstruction in channels, dispelling wind The features such as having one's ideas straightened out, removing necrosis and promoting granulation, is nontoxic, is safe and efficient cannot be only used for otitis caused by many reasons, ear itching, otalgia Etc. symptoms treatment and prevention, also significantly mitigate or alleviate tinnitus effect, meanwhile, also can be used as there is no ear suffer from children And daily ear health treatment of the normal adult for the refreshing ear of clear ear, add its feature easy to use so that the product has There is good society generalization application value.
Details are as follows for the technical solution that the application is taken.
A kind of to treat otitis and the auristilla for ear function of feeling well with clear ear, which includes natural anti-inflammatory bacteriostatic agent, cell life Reason function regulator, cell-protecting, cellular agonist, promoting blood circulation and removing obstruction in channels dose, intelligence hardening agent, antioxidant and cell are normally given birth to The long required agent of metabolism, under preferable case, which further includes preservative, further preferably in the case of, which further includes this hair The acceptable safety barrier of bright preparation or auxiliary material；
The natural anti-inflammatory bacteriostatic agent, including but not limited to Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extraction One of which or several arbitrary proportion mixtures may be selected in object, Angelica Dahurica extract, menthol, peppermint oil；
The cell physiological function regulator makees the physiological function of the relevant soma of ear organ with important adjusting With being made of vitamins and coenzyme substance；
One of which or the mixing of several arbitrary proportions may be selected in the cell-protecting, including but not limited to trehalose, allantoin Object；
One of which or several arbitrary proportions may be selected in the cellular agonist, including but not limited to ATP disodiums, cromoci Mixture；
Described promoting blood circulation and removing obstruction in channels dose, including but not limited to Notogineng Extract, notoginseng total saponin/glycosides, VB12, may be selected one of which or Several arbitrary proportion mixtures；
One of which or several may be selected in the intelligence hardening agent, including but not limited to zinc gluconate, zinc lactate, zinc citrate Kind arbitrary proportion mixture；
One of which or several arbitrary may be selected in the antioxidant, including but not limited to taurine, VC sodium, phytic acid, phytate Scalemic thereof；
The required agent of cell normal growth metabolism, including but not limited to amino acids, lactic acid class, inositol, may be selected wherein one Kind or the combination of several arbitrary proportions；
The preservative should be food grade preservative, including but not limited to potassium sorbate, dehydroactic acid sodium, potassium cinnamate, Radix Glycyrrhizae One of which or several arbitrary proportion mixtures may be selected in acid, glycyrrhetate, propionate；
The acceptable safety barrier of the invention formulation or auxiliary material be prepare solvent needed for auristilla of the present invention and auxiliary agent or Other auxiliary materials.
It is described it is a kind of treat otitis and with clear ear feel well ear function auristilla, the auristilla be liquor, total matter of effective ingredient A concentration of 0.5-20.0% is measured, surplus is solvent；Each composition is in terms of mass fraction in effective ingredient, specially：
The natural anti-inflammatory bacteriostatic agent, is carried by Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica Object, menthol and peppermint oil is taken to constitute, specifically：Nantural non-toxic Chinese herbal medicine alcohol extract 1.0-80.0, Honegsukle flower P.E 0.01-9.0, chrysanthemum extract 0.01-6.0, Angelica Dahurica extract 0.01-6.0, menthol 0.01-10.0, peppermint oil 0.01- 6.0；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 0.01-6.0, vitamin V B2 0.001-1.0, niacinamide 0.01-10.0, VB5 0.01-6.0, VB6 0.01-6.0, niacin 0.01-5.0, Vc 0.01-5.0, Ve 0.001-1.0, biotin 0.001-1.0, Co-Q10 0.001-1.0, Coenzyme I 0.001-2.0, Coenzyme I I 0.001-2.0；
The cell-protecting, is made of trehalose and allantoin, specifically：Trehalose 0.01-9.0, allantoin 0.001- 2.0；
The cellular agonist is made of, specifically ATP disodiums and cromoci：ATP disodiums 0.01-5.0, cell color Plain C 0.001-5.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically：Notogineng Extract 0.01-10.0, notoginseng total saponin/glycosides 0.001-2.0, VB12 0.01-10.0；
The intelligence hardening agent, be zinc gluconate, zinc lactate, zinc citrate, specifically：Zinc gluconate 0.01-4.0, Zinc lactate 0.01-4.0, zinc citrate 0.01-4.0；
The antioxidant is taurine, VC sodium, phytic acid, phytate；Specifically：Taurine 0.01-5.0, VC sodium 0.01- 5.0, phytic acid 0.01-5.0, phytate 0.01-5.0；
The required agent of cell normal growth metabolism, is made of, specifically amino acids, lactic acid class and inositol：
Arginine 0.001-5.0, serine 0.001-5.0, glycine 0.001-9.0, glutamic acid 0.001-1.0, glutamine 0.01-8.0, lactic acid 0.01-5.0, sodium lactate 0.01-5.0, sodium glutamate 0.01-3.0；Inositol 0.01-6.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body：It is potassium sorbate 0.01-2.0, dehydroactic acid sodium 0.01-2.0, potassium cinnamate 0.01-2.0, glycyrrhizic acid 0.01-1.0, sweet Oxalates 0.01-3.0, propionate 0.01-2.0；
The glycyrrhetate is one or two kinds of arbitrary proportion mixtures in potassium glycyrrhizana, sodium glycyrrhetate；
The propionate is one or two kinds of arbitrary proportion mixtures in sodium propionate, calcium propionate.
The solvent refers to or mixtures thereof purified water or 95% ethyl alcohol, and required raw material can be dissolved by being subject to.
The auristilla of the treatment otitis and ear function of feeling well with clear ear, in further optimization formula, effective ingredient it is total Mass concentration is 1.0-18.0%, and surplus is water；Each composition is in terms of mass fraction in effective ingredient, specially：
The natural anti-inflammatory bacteriostatic agent, is carried by Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica Object, menthol and peppermint oil is taken to constitute, specifically：Nantural non-toxic Chinese herbal medicine alcohol extract 2.0-76.0, Honegsukle flower P.E 0.01-8.0, chrysanthemum extract 0.01-5.0, Angelica Dahurica extract 0.01-5.0, menthol 0.01-8.0, peppermint oil 0.01- 5.0；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 0.01-5.0, vitamin V B2 0.001-0.5, niacinamide 0.01-8.0, VB5 0.01-5.0, VB6 0.01-5.0, niacin 0.01-4.0, Vc 0.01-4.0, Ve 0.01-1.0；Biotin 0.001-0.60, Co-Q10 0.01- 1.0, Coenzyme I 0.01-1.20, Coenzyme I I 0.01-1.60；
The cell-protecting, is made of trehalose and allantoin, specifically：Trehalose 0.01-6.0, allantoin 0.01- 1.0；
The cellular agonist is made of, specifically ATP disodiums and cromoci：ATP disodiums 0.01-4.0, cell color Plain C 0.01-4.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically：Notogineng Extract 0.01-8.0, notoginseng total saponin/glycosides 0.01-1.80, VB12 0.01-8.0；
The intelligence hardening agent, be zinc gluconate, zinc lactate, zinc citrate, specifically：Zinc gluconate 0.01-3.0, Zinc lactate 0.01-3.0, zinc citrate 0.01-3.0；
The antioxidant is taurine, VC sodium, phytic acid, phytate；Specifically：Taurine 0.01-4.0, VC sodium 0.01- 4.0, phytic acid 0.01-4.0, phytate 0.01-4.0；
The required agent of cell normal growth metabolism, is made of, specifically amino acids, lactic acid class and inositol：Arginine 0.001-4.0, serine 0.001-3.0, glycine 0.001-6.0, glutamic acid 0.01-1.0, glutamine 0.01-5.0, breast Sour 0.01-3.0, sodium lactate 0.01-4.0, sodium glutamate 0.01-2.0；Inositol 0.01-5.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body：Potassium sorbate 0.01-1.80, dehydroactic acid sodium 0.01-1.80, potassium cinnamate 0.01-1.80, glycyrrhizic acid 0.01- 0.80, glycyrrhetate 0.01-2.0, propionate 0.01-1.80.
The auristilla of the treatment otitis and ear function of feeling well with clear ear, in ear refreshing for tinnitus or clearly ear, cephalomenia Auristilla is instilled by earhole in external auditory canal, massage effect is aided with after drop more preferably by side；In terms of dosage, 1-3 drops/time, 1-3 times/ Day；It is about 0.02-0.04mL per drop volume；When for tinnitus treatment, increase and decrease access times and dosage, tinnitus symptom can be taken the circumstances into consideration Just when serious to drip, tinnitus is just dripped less when mitigating, but must not be dripped more；When the clear refreshing ear of ear is good for Er Shuer, it can take the circumstances into consideration to reduce make With number and dosage, 1 time a day, 1-3 drops/time, it can uninterruptedly use for a long time.
The another object of the application, which also resides in provide, a kind for the treatment of otitis and the preparation for the ear function auristilla of feeling well with clear ear Method.
The preparation method of the treatment otitis and ear function auristilla of feeling well with clear ear, specifically comprises the following steps：
（1）Effective ingredient in auristilla is divided into 4 groups according to material properties and the convenience of preparation and easy property processed, weighs match respectively Dosage is spare in side, specifically：
First group, glycitols compound specifically has：Trehalose, inositol, zinc gluconate；
Second group, amino acids specifically have：Arginine, serine, glycine, glutamic acid, glutamine, glutamic acid Sodium；
Third group, vitamin coenzymes class compound, specifically has：Vitamin V B1, vitamin V B2, niacinamide, VB5, VB6, niacin, Vc、Ve；Biotin, Co-Q10, Coenzyme I, Coenzyme I I, VB12；
4th group, unclassified stores, specifically has in addition to the solvents：Allantoin, ATP disodiums, cromoci, notoginseng total saponin/glycosides, ox Sulfonic acid, potassium sorbate, dehydroactic acid sodium, lactic acid, sodium lactate, zinc lactate, zinc citrate, VC sodium, phytic acid, phytate, cinnamic acid Potassium, glycyrrhizic acid, glycyrrhetate, propionate, Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica carry Take object, menthol and peppermint oil；
（2）By step（1）In second group of material weighing be placed in reaction kettle, the solvent of part formulation amount, stirring is then added Mixing is dissolved, is stood, mixture A is obtained after filtering and impurity removing；
（3）By step（1）In the third group that weighs and the 4th group of material be placed in reaction kettle, the molten of part formulation amount is then added Agent, stirring and dissolving mixing are stood, and mixture B is obtained after filtering and impurity removing；
（4）By step（3）Mixture B be slowly added into step（2）Mixture A in, after the completion of addition, be added step（1） In first group of material component weighing, be eventually adding the solvent and auxiliary agent of remainder formula ratio, dissolving mixing, filtering and impurity removing, PH=3.5 ~ 7.5 are adjusted, this is auristilla product provided herein.
Step（2）, step（3）, step（4）In carry out dissolving mixing operation when, operation temperature should not be greater than 45 DEG C, in order to avoid The stability of drug effect is influenced, but is also not lower than 10 DEG C, in order to avoid influencing dissolving and mixed effect, preferably 24 DEG C or so are dissolved Mixing operates.
Step（2）, step（3）, step（4）In carry out dissolving mixing operation when, it is preferred to use the homogeneous under vacuum condition Emulsifying manner is operated, and can preferably ensure mixed effect.
Wherein, the Nantural non-toxic Chinese herbal medicine alcohol extract in the natural anti-inflammatory bacteriostatic agent contains the group of following mass fraction Divide and is made by following processes：30~90 parts of honeysuckle, 40~80 parts of chrysanthemum, 40~75 parts of licorice, pueraria lobata 40~75 Part, 40~75 parts of Radix Salviae Miltiorrhizae, 20~55 parts of Radix Astragali, 30~60 parts of Radix Notoginseng, 10~50 parts of Radix Angelicae Sinensis, windproof 30~70 parts, schizonepeta 15~ 70 parts, 20~80 parts of peppermint, 15~50 parts of the root of Dahurain angelica, 15~50 parts of akebi, 15~90 parts of Centipeda minima；Its process of preparing packet It includes：The formula Chinese medicine is weighed, the particle that grain size is grain of rice size is crushed to, addition is equivalent to the dense of 5-20 times of quality of mixture Degree is 10-90%（V/V）Ethyl alcohol, then multi-functional in including but not limited to vacuum or/and normal pressure or/and positive pressure environment More than a few hours extracting solution is collected by filtration up to the alcohol extract in extraction under the conditions of set temperature is 20-105 DEG C in extractor.
The major design theory of the application is：The considerations of for safety first principle, raw material prescription of the present invention are same with traditional medicine food Based on the Chinese herbal medicine that there is broad-spectrum antiseptic anti-inflammatory, clearing heat and detoxicating, promoting blood circulation and removing blood stasis, dispelling wind to have one's ideas straightened out in source, remove necrosis and promote granulation, it is aided with state The tool of family's food or health food or food additives and nutrition fortifier or the above standard of National Pharmacopeia grade having no toxic side effect There is anti-inflammatory anti-anaphylaxis and there is important conditioning and rehabilitative action, simultaneously to ear cranial nerve muscle cell and micro- blood circulation system Also it with Nutritional Nursing Care ear brain and the biogenic substances for keeping ear brain pleasant and other effects be food-borne or drug induccd raw material or component, and uses It is a kind of made of a kind of low-temperature environment-friendly technology method is refined can be with the preparation of target administration.According to modern medicine and traditional Chinese medicine The theory of " being imitated in Transdermal absorption, external application " in, auristilla of the present invention not only have the function for the treatment of the ears diseases such as otitis, may be used also Important conditioning and rehabilitative action are played to ear cranial nerve muscle cell and micro- blood circulation system.Simultaneously, it may have nutrition is protected Reason ear brain and the effect for keeping ear brain pleasant.
Compared with traditional treatment otitis product or technical method, the advantages of the application, is mainly manifested in the following aspects：
（1）Compared with traditional treatment otitis drug, the auristilla without any to human body toxic side effect or harmful ingredient, it Be it is a kind of there is broad-spectrum antiseptic anti-inflammatory, clearing heat and detoxicating, promoting blood circulation and removing blood stasis, dispelling wind to have one's ideas straightened out, remove necrosis and promote granulation, anti-inflammatory anti-anaphylaxis, nutrition skin The targeting preparation having no toxic side effect；
（2）Product of the present invention is different from the oral or injectable Western medicine or form of Chinese drug of traditional treatment otitis, not liver " first pass effect ", dosage is few, with obvious effects direct；In addition, its application method is simple and convenient, it is not only not necessarily to health care professional Operation or guidance, can also use whenever and wherever possible；
（3）Auristilla of the present invention can not only be used for the therapeutic agent of otitis patient, but also as the ear health treatment of normal healthy people；
（4）The preparation method mild condition of auristilla of the present invention, simple for process, non-environmental-pollution.Due to the raw materials used in the present invention It is more sensitive to physical and chemical factors such as high temperature and illumination for biogenic substances component, so, by process optimization, establishing one kind can To prepare simple for process, non-environmental-pollution the technical method of auristilla of the present invention under room temperature or low temperature；Not only environmental protection but also section Energy；
（5）The effect of product of the present invention existing drug, but having can be prolonged and repeated edible or the health food that uses and cosmetics Safety.Though product of the present invention is externally applied product, its safety both can reach interior use（It is oral）Health food（Existing adjusting machine The effect of body function will not also generate human body any acute, subacute or chronic hazard food）Standard, meanwhile, it also complies with It can long-term external application《Cosmetics safety technical specification》Etc. national standards.
Specific implementation mode
Explanation is further explained to the application with reference to embodiment.
Embodiment 1
The present embodiment provides it is a kind of treat otitis and with clear ear feel well ear function auristilla, the auristilla be liquor, effectively at The total mass concentration of part is 6%, and surplus is water, pH=5.0；Each composition is in terms of mass fraction in effective ingredient, specially：
The natural anti-inflammatory bacteriostatic agent, is carried by Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica Object, menthol and peppermint oil is taken to constitute, specifically：Nantural non-toxic Chinese herbal medicine alcohol extract 40.0, Honegsukle flower P.E 5.0, chrysanthemum Flower extract 3.0, Angelica Dahurica extract 3.0, menthol 5.0, peppermint oil 3.0；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 5.0, vitamin V B2 0.5, niacinamide 8.0, VB5 4.0, VB6 3.0, niacin 4.0, Vc 1.0, Ve 0.4；Biotin 0.6, Co-Q10 0.6, Coenzyme I 0.8, Coenzyme I I 0.9；
The cell-protecting, is made of trehalose and allantoin, specifically：Trehalose 4.5, allantoin 0.9；
The cellular agonist is made of, specifically ATP disodiums and cromoci：ATP disodiums 4.0 and cromoci 4.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically：Notogineng Extract 4.0, notoginseng total saponin/glycosides 0.6, VB12 8.0；
The intelligence hardening agent, be zinc gluconate, zinc lactate, zinc citrate, specifically：Zinc gluconate 2.0, zinc lactate 3.0, zinc citrate 1.0；
The antioxidant is taurine, VC sodium, phytic acid, phytate；Specifically：Taurine 1.0, VC sodium 2.0, phytic acid 2.0, phytate 2.0；
The required agent of cell normal growth metabolism, is made of, specifically amino acids, lactic acid class and inositol：
Arginine 4.0, serine 1.0, glycine 8.0, glutamic acid 0.9, glutamine 7.0, lactic acid 4.0, sodium lactate 4.0, paddy Propylhomoserin sodium 2.0, inositol 4.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, dipotassium glycyrrhizinate and sodium propionate, tool For body：Potassium sorbate 1.0, dehydroactic acid sodium 0.8, potassium cinnamate 0.8, glycyrrhizic acid 0.5, dipotassium glycyrrhizinate 2.0, sodium propionate 0.9.
Wherein, the Nantural non-toxic Chinese herbal medicine alcohol extract in the natural anti-inflammatory bacteriostatic agent contains the group of following mass fraction Divide and is made by following processes：60 parts of honeysuckle, 60 parts of chrysanthemum, 50 parts of licorice, 50 parts of pueraria lobata, 50 parts of Radix Salviae Miltiorrhizae, Radix Astragali 40 parts, 40 parts of Radix Notoginseng, 35 parts of Radix Angelicae Sinensis, windproof 40 parts, 40 parts of schizonepeta, 50 parts of peppermint, 35 parts of the root of Dahurain angelica, 30 parts of akebi, Centipeda minima 60 parts；Its process of preparing includes：The formula Chinese medicine is weighed, the particle that grain size is grain of rice size is crushed to, is added suitable In a concentration of 10-90% of 5-20 times of quality of mixture（V/V）Ethyl alcohol, then in multi-functional extractor set temperature be 20- A few hours are extracted under the conditions of 105 DEG C, extracting solution is collected by filtration up to the alcohol extract.
Specific when preparing, that steps are as follows is described for preparation method：
（1）Effective ingredient in auristilla is divided into 4 groups according to material properties and the convenience of preparation and easy property processed, weighs match respectively Dosage is spare in side, specifically：
First group, glycitols compound specifically has：Trehalose, inositol, zinc gluconate；
Second group, amino acids specifically have：Arginine, serine, glycine, glutamic acid, glutamine, glutamic acid Sodium；
Third group, vitamin coenzymes class compound, specifically has：Vitamin V B1, vitamin V B2, niacinamide, VB5, VB6, niacin, Vc、Ve；Biotin, Co-Q10, Coenzyme I, Coenzyme I I, VB12；
4th group, unclassified stores, specifically has in addition to the solvents：Allantoin, ATP disodiums, cromoci, notoginseng total saponin/glycosides, ox Sulfonic acid, potassium sorbate, dehydroactic acid sodium, lactic acid, sodium lactate, zinc lactate, zinc citrate, VC sodium, phytic acid, phytate, cinnamic acid Potassium, glycyrrhizic acid, glycyrrhetate, propionate, Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica carry Take object, menthol and peppermint oil；
（2）By step（1）In second group of material weighing be placed in reaction kettle, the solvent of part formulation amount, stirring is then added Mixing is dissolved, is stood, mixture A is obtained after filtering and impurity removing；
（3）By step（1）In the third group that weighs and the 4th group of material be placed in reaction kettle, the molten of part formulation amount is then added Agent, stirring and dissolving mixing are stood, and mixture B is obtained after filtering and impurity removing；
（4）By step（3）Mixture B be slowly added into step（2）Mixture A in, after the completion of addition, be added step（1） In first group of material component weighing, be eventually adding the solvent and auxiliary agent of remainder formula ratio, dissolving mixing, filtering and impurity removing, PH=5.0 are adjusted, this is auristilla product provided herein.
Step（2）, step（3）, step（4）In carry out dissolving mixing operation when, using the emulsifying under vacuum condition Mode carries out dissolving mixing operation at 30 DEG C or so, preferably to ensure mixed effect.
To the skin irritation and pollutant of auristilla product prepared by the present embodiment（Heavy metal）Etc. safety indexes into Detection is gone, as a result as shown in the following table 1, table 2（Every Testing index listed by table 1,2 is by can often eat（It uses）'s The safe standard GB/T 16740-2014 of health food and《Cosmetics safety technical specification》（Version in 2015）New standard is held Row）.
1 skin irritation of table and pollutant（Heavy metal）Testing result
Index name Testing result Health food standarda Cosmetic standardb Remarks
Multiple skin irritation 0 degree 2 degree or less
Mercury (Hg), mg/kg ≤ 0.18 0.3 1
Arsenic (As), mg/kg ≤ 0.6 1 2
Lead（Pb）, mg/kg ≤ 1.5 2 10
Cadmium（Cd）, mg/kg ≤ 1.8 5
Dioxane, mg/kg ≤ 4.2 30
Methanol, mg/kg ≤ 147 2000
Asbestos It is not detected It must not detect
Note： aIt refer to GB 16740-2014 national food safety standard-health food safety standard； bIt refer to state food medicine The new edition that product supervision and management general bureau promulgates《Cosmetics safety technical specification》（Version in 2015）（2015 No. 268）.
2 microbiological indicator of table
Project Index Health food standarda Cosmetic standardb
Total plate count, CFU/g or CFU/mL≤ 89 1000 1000
Heat-resisting coliform MPN/g, or/mL Nothing 0.43 Nothing
Staphylococcus aureus/g, or/mL 0/25g 0/25g 0/25g
Pseudomonas aeruginosa/g, or/mL 0/25g 0/25g 0/25g
Salmonella/g, or/mL 0/25g 0/25g 0/25g
Yeast and mold, CFU/g or CFU/mL≤ 11 50 50
The detection knot of the safety indexes such as pollutants and microorganism such as heavy metal of auristilla of the present invention it can be seen from table 1 and 2 Fruit not only complies fully with the safe standard GB/T 16740-2014 of the health food that can often eat, and also being compliant with can be long-term What is used is newest《Cosmetics safety technical specification》（Version in 2015）Standard.
By taking auristilla product prepared by the present embodiment as an example, inventor has carried out part actual human body application experiment（It is voluntary Person）, detailed process is briefly discussed below.
The practical application effect of otitis patient
220 other normal 7-63 Sui otitis patients of age of sign are selected, are randomly divided into 2 groups：A groups control group and the experiment of B groups Group, every group 110, A groups Ofloxacin class auristilla, B groups auristilla of the present invention.Usage：Cephalomenia side, by auristilla Liquid outlet is directed at duct, instills in ear, and a moment is massaged after drop.Dosage：1-6 drops/time, 1-3 times/day, the course for the treatment of is generally 7-14 days, It can take the circumstances into consideration increase and decrease access times and dosage according to the state of an illness.Efficacy assessment standard：With reference to country《Antibacterials clinical research guidance is former Then》It formulates as follows：Recovery from illness：Otitis inflammatory resolution, other sign symptoms are normal；It is effective：The state of an illness is clearly better but does not restore completely Normally；Effectively：The state of an illness is improved after medication, but not apparent enough；In vain：The state of an illness adds severe one without obviously improving or having after medication. As a result it is：A groups total effective rate 87.8%（P<0.01）, the total effective rate 96.5% of B groups（P<0.01）, illustrate auristilla of the present invention Curative effect is better than Common Antibiotics Ofloxacin class, achieves ideal effect.
The application effect of Normal volunteers
The random non-otitis health men and women volunteer for selecting 196 ages 18-70 Sui tries out product of the present invention, checks trier's With rear feeling.Usage：The liquid outlet of auristilla is directed at duct by cephalomenia side, is instilled one and is picked up the ears interior, massage a moment after drop, separately It does not drip as control side.Dosage：1-3 drops/time, 1-3 times/day, increase and decrease access times and dosage can be taken the circumstances into consideration according to personal like. Effective evaluation is carried out after 2 months on probation.Effective evaluation index or standard：With reference to country《Antibacterials guideline of clinical investigations》 Feel to be divided into following 4 kinds of situations after formulating the use of trier： A：Feel pleasant penetrating, the other side is also intended to seek drop；B:Feel compared with It is good；C:Feel general or insentience；D:Feel to feel bad.As a result it is：A 163（83.2%）, B 24（12.2%）, C 9 （4.6%）, D 0（0.0%）, feel that pleasant penetrating person accounts for 83.2%, in addition feeling preferable person 12.2%, the pleasant rate of panesthesia is 95.4%（P<0.01）, achieve ideal effect.
Overall application effect shows：For newly sending out otitis patient serious, apparent mitigation can have been experienced after instilling for the first time With mitigation；And be directed to healthy population, instill one pick up the ears it is interior after, which can allow the healthy human ear being dropped into be felt more Penetrating, more pleasant, most volunteers can also ask to drip another ear again.
For above-mentioned experiment, just it is described below using the briefly citing of the part model case situation of process：
Lee：Female, 63 years old, certain government functionary was retired, suffers from tympanitis for many years, controls be not cured long, dripped ear using product of the present invention, Dosage：2-5 drops/time, 2-3 times/day or each drop 1 time daily morning and evening.It uses ear sense pleasant for the first time, is had using 1 week symptom apparent Mitigate, was almost recovered using 6 weeks or so.
Mr. Wang, male, 55 years old, certain college professor, aggravation before otitis tinnitus more than 10 years, 4 years, a variety of medical procedures of seeking help It has no result, drips ear, dosage using product of the present invention：2-10 drops/time, it 1-6 times/day, was taken an evident turn for the better using 2 weeks or so.Extremely The present uses auristilla of the present invention more than 3 years, and not only tinnitus symptom is substantially reduced, and otitis also has no other adverse reactions.
Zhao, female, 50 years old, certain college professor, the otitis that arrives because of pharyngitis happened suddenly serious tinnitus 1 day in turn, ear intracerebral diseases caused by external factors Feel hurricane your writing and influence thinking ability, drips ear, dosage using product of the present invention：2-10 drops/time, it 1-6 times/day, uses for the first time Symptom has substantially reduced, is almost recovered using 2 weeks or so.
Zhang：Female, 64 years old, certain government functionary was retired, health, dripped ear, dosage using product side of the present invention： 1-3 drops/time, 1-3 times/day or each drop 1 time daily morning and evening.Using for the first time i.e. have pleasant penetrating more invigorative feeling, the other side Also it is intended to instill.Or so April is used continuously, other than pleasant penetrating more invigorative feeling, has no other adverse reactions.
Liu：Man, 32 years old, certain company manager, health dripped ear, dosage using product side of the present invention：1-3 drops/ It is secondary, 1-3 times/day or each drop 1 time daily morning and evening.Using for the first time i.e. there is pleasant penetrating more invigorative feeling, the other side to be also intended to drip Enter.Continuous use 2 months or so, other than pleasant penetrating more invigorative feeling, has no other adverse reactions.
Hu：Female, 21 years old, certain company clerk, health dripped ear, dosage using product side of the present invention：1-3 drops/ It is secondary, 1-3 times/day.Using having pleasant penetrating more invigorative feeling for the first time, the other side also wants to instill.It is left that June is used continuously The right side has no other adverse reactions other than pleasant penetrating more invigorative feeling.
Embodiment 2
The auristilla product for the treatment of otitis and ear function of feeling well with clear ear that the present embodiment is provided, preparation method is substantially the same as real Example 1 is applied, only adjustment member formula is as follows：
The auristilla is liquor, and the total mass concentration of effective ingredient is 0.5%, and surplus is water, pH=3.5；In effective ingredient respectively at Part is in terms of mass fraction, specially：
The natural anti-inflammatory bacteriostatic agent, is carried by Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica Object, menthol and peppermint oil is taken to constitute, specifically：Nantural non-toxic Chinese herbal medicine alcohol extract 80.0, Honegsukle flower P.E 0.01, Chrysanthemum extract 0.01, Angelica Dahurica extract 0.01, menthol 0.01, peppermint oil 0.01；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 0.01, VB2 0.001, niacinamide 0.01, VB5 0.01, VB6 0.01, niacin 0.01, Vc 0.01, Ve 0.001；Biotin 1.0, Co-Q10 0.001, Coenzyme I 2.0, Coenzyme I I 2.0；
The cell-protecting, is made of trehalose, specifically：Trehalose 0.01；
The cellular agonist is made of, specifically ATP disodiums：ATP disodiums 5.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of notoginseng total saponin/glycosides, specifically：Notoginseng total saponin/glycosides 2.0；
The intelligence hardening agent, be zinc gluconate, zinc lactate, zinc citrate, specifically：Zinc gluconate 4.0, zinc lactate 4.0, zinc citrate 4.0；
The antioxidant is taurine, VC sodium, phytic acid, phytate；Specifically：Taurine 5.0, VC sodium 5.0, phytic acid 5.0, phytate 5.0；
The required agent of cell normal growth metabolism, is made of, specifically amino acids：It is arginine 5.0, serine 5.0, sweet Propylhomoserin 9.0, glutamic acid 1.0；
The preservative, is made of potassium sorbate and dehydroactic acid sodium, specifically：Potassium sorbate 2.0, dehydroactic acid sodium 0.01。
Wherein, the Nantural non-toxic Chinese herbal medicine alcohol extract in the natural anti-inflammatory bacteriostatic agent contains the group of following mass fraction Divide and is made by following processes：90 parts of honeysuckle, 80 parts of chrysanthemum, 75 parts of licorice, 75 parts of pueraria lobata, 75 parts of Radix Salviae Miltiorrhizae, Radix Astragali 255 parts, 60 parts of Radix Notoginseng, 50 parts of Radix Angelicae Sinensis, windproof 30 parts, 15 parts of schizonepeta, 20 parts of peppermint, 15 parts of the root of Dahurain angelica, 15 parts of akebi, Centipeda minima 15 parts；Its process of preparing includes：The formula Chinese medicine is weighed, the particle that grain size is grain of rice size is crushed to, is added suitable In a concentration of 10-90% of 5-20 times of quality of mixture（V/V）Ethyl alcohol, then in multi-functional extractor set temperature be 20- A few hours are extracted under the conditions of 105 DEG C, extracting solution is collected by filtration up to the alcohol extract.
Embodiment 3
The auristilla product for the treatment of otitis and ear function of feeling well with clear ear that the present embodiment is provided, preparation method is substantially the same as real Example 1 is applied, only adjustment member formula is as follows：
The auristilla is liquor, and the total mass concentration of effective ingredient is 20.0%, and surplus is water, pH=7.5；In effective ingredient respectively at Part is in terms of mass fraction, specially：
The natural anti-inflammatory bacteriostatic agent, is carried by Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica Object, menthol and peppermint oil is taken to constitute, specifically：Nantural non-toxic Chinese herbal medicine alcohol extract 1.0, Honegsukle flower P.E 9.0, chrysanthemum Flower extract 6.0, Angelica Dahurica extract 6.0, menthol 10.0, peppermint oil 6.0；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 6.0, VB2 1.0, niacinamide 10.0, VB5 6.0, VB6 6.0, niacin 5.0, Vc 5.0, Ve 1.0；
Biotin 0.001, Co-Q10 1.0, Coenzyme I 0.001, Coenzyme I I 0.001；
The cell-protecting, is made of trehalose and allantoin, specifically：Trehalose 9.0, allantoin 0.001；
The cellular agonist is made of, specifically ATP disodiums and cromoci：ATP disodiums 0.01 and cromoci 5.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically：Notogineng Extract 10.0, notoginseng total saponin/glycosides 0.001, VB12 10.0；
The intelligence hardening agent, be zinc gluconate, zinc lactate, zinc citrate, specifically：Zinc gluconate 0.01, lactic acid Zinc 0.01, zinc citrate 0.01；
The antioxidant is taurine, VC sodium, phytic acid, phytate；Specifically：Taurine 0.01, VC sodium 0.01, phytic acid 0.01, phytate 0.01；
The required agent of cell normal growth metabolism, is made of, specifically amino acids, lactic acid and inositol：
Arginine 0.001, serine 0.001, glycine 0.001, glutamic acid 0.001, glutamine 0.01, lactic acid 0.01, paddy Propylhomoserin sodium 0.01, inositol 0.01；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, Carbenoxolone Sodium and sodium propionate, tool For body：Potassium sorbate 0.01, dehydroactic acid sodium 2.0, potassium cinnamate 0.01, glycyrrhizic acid 0.05, Carbenoxolone Sodium 0.01, sodium propionate 0.01。
Wherein, the Nantural non-toxic Chinese herbal medicine alcohol extract in the natural anti-inflammatory bacteriostatic agent contains the group of following mass fraction Divide and is made by following processes：30 parts of honeysuckle, 40 parts of chrysanthemum, 40 parts of licorice, 40 parts of pueraria lobata, 40 parts of Radix Salviae Miltiorrhizae, Radix Astragali 20 parts, 30 parts of Radix Notoginseng, 10 parts of Radix Angelicae Sinensis, windproof 70 parts, 70 parts of schizonepeta, 80 parts of peppermint, 50 parts of the root of Dahurain angelica, 50 parts of akebi, Centipeda minima 90 parts；Its process of preparing includes：The formula Chinese medicine is weighed, the particle that grain size is grain of rice size is crushed to, is added suitable In a concentration of 10-90% of 5-20 times of quality of mixture（V/V）Ethyl alcohol, then in multi-functional extractor set temperature be 20- A few hours are extracted under the conditions of 105 DEG C, extracting solution is collected by filtration up to the alcohol extract.
Embodiment 4
The auristilla product for the treatment of otitis and ear function of feeling well with clear ear that the present embodiment is provided, preparation method is substantially the same as real Example 1 is applied, only adjustment member formula is as follows：
The auristilla is liquor, and the total mass concentration of effective ingredient is 3%, and surplus is water, pH=4.0；Each composition in effective ingredient In terms of mass fraction, specially：
The natural anti-inflammatory bacteriostatic agent, is carried by Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica Object, menthol and peppermint oil is taken to constitute, specifically：Nantural non-toxic Chinese herbal medicine alcohol extract 10.0, Honegsukle flower P.E 1.0, chrysanthemum Flower extract 1.0, Angelica Dahurica extract 1.0, menthol 1.0, peppermint oil 1.0；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 3.0, VB2 0.5, niacinamide 5.0, VB5 3.0, VB6 3.0, niacin 3.0, Vc 3.0, Ve 0.5；
Biotin 0.5, Co-Q10 0.5, Coenzyme I 1.0, Coenzyme I I 1.0；
The cell-protecting, is made of trehalose and allantoin, specifically：Trehalose 4.0, allantoin 1.0；
The cellular agonist is made of, specifically ATP disodiums and cromoci：ATP disodiums 3.0 and cromoci 2.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of notoginseng total saponin/glycosides and VB12, specifically：Notoginseng total saponin/glycosides 1.0, VB12 5.0；
The intelligence hardening agent is zinc gluconate, specifically：Zinc gluconate 2.0；
The antioxidant is taurine；Specifically：Taurine 3.0；
The required agent of cell normal growth metabolism, is made of, specifically amino acids, sodium lactate and inositol：Arginine 3.0, serine 3.0, glycine 5.0, glutamic acid 0.5, glutamine 4.0, sodium lactate 3.0, sodium glutamate 2.0, inositol 3.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, Carbenoxolone Sodium and calcium propionate, tool For body：Potassium sorbate 1.0, dehydroactic acid sodium 1.0, potassium cinnamate 1.0, glycyrrhizic acid 0.5, Carbenoxolone Sodium 2.0, calcium propionate 1.0.
Embodiment 5
The auristilla product for the treatment of otitis and ear function of feeling well with clear ear that the present embodiment is provided, preparation method is substantially the same as real Example 1 is applied, only adjustment member formula is as follows：
The auristilla is liquor, and the total mass concentration of effective ingredient is 9%, and surplus is water, pH=5.5；Each composition in effective ingredient In terms of mass fraction, specially：
The natural anti-inflammatory bacteriostatic agent, is carried by Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica Object, menthol and peppermint oil is taken to constitute, specifically：Nantural non-toxic Chinese herbal medicine alcohol extract 30.0, Honegsukle flower P.E 3.0, chrysanthemum Flower extract 2.0, Angelica Dahurica extract 2.0, menthol 3.0, peppermint oil 2.0；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 1.0, VB2 0.1, niacinamide 1.0, VB5 1.0, VB6 1.0, niacin 1.0, Vc 0.5, Ve 0.05；
Biotin 0.01, Co-Q10 0.5；
The cell-protecting, is made of trehalose and allantoin, specifically：Trehalose 3.0, allantoin 0.01；
The cellular agonist is made of, specifically ATP disodiums and cromoci：ATP disodiums 0.5 and cromoci 0.05；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically：Notogineng Extract 4.0, notoginseng total saponin/glycosides 0.01, VB12 2.0；
The intelligence hardening agent is zinc gluconate, specifically：Zinc gluconate 0.05；
The antioxidant is taurine；Specifically：Taurine 1.0；
The required agent of cell normal growth metabolism, is made of, specifically amino acids, lactic acid class and inositol：
Arginine 1.0, serine 1.0, glycine 2.0, glutamic acid 0.01, glutamine 1.0, lactic acid 1.0, sodium lactate 1.0, paddy Propylhomoserin sodium 1.0, inositol 1.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, Carbenoxolone Sodium and sodium propionate, tool For body：Potassium sorbate 0.05, dehydroactic acid sodium 0.2, potassium cinnamate 0.05, glycyrrhizic acid 0.5, Carbenoxolone Sodium 0.05, sodium propionate 0.05；
Embodiment 6
The auristilla product for the treatment of otitis and ear function of feeling well with clear ear that the present embodiment is provided, preparation method is substantially the same as real Example 1 is applied, only adjustment member formula is as follows：
The auristilla is liquor, and the total mass concentration of effective ingredient is 12%, and surplus is water, adjusts pH=6.0；It is each in effective ingredient Composition is in terms of mass fraction, specially：
The natural anti-inflammatory bacteriostatic agent, is made of, specifically Honegsukle flower P.E, chrysanthemum extract oil：Honegsukle flower P.E 4.0, chrysanthemum extract 5.0；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 2.0, VB2 0.03, niacinamide 4.0, VB5 2.0, VB6 2.0, niacin 2.0；
Biotin 0.05, Co-Q10 0.5；
The cell-protecting, is made of trehalose and allantoin, specifically：Trehalose 4.0, allantoin 0.05；
The cellular agonist is made of, specifically ATP disodiums and cromoci：ATP disodiums 2.0 and cromoci 0.5；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically：Notogineng Extract 8.0, notoginseng total saponin/glycosides 0.08, VB12 4.0；
The intelligence hardening agent is zinc gluconate, specifically：Zinc gluconate 0.8；
The antioxidant is taurine；Specifically：Taurine 2.0；
The required agent of cell normal growth metabolism, is made of, specifically amino acids, lactic acid class and inositol：
Arginase 12 .0, serine 2.0, glycine 4.0, glutamic acid 0.1, glutamine 5.0, lactic acid 2.0, sodium lactate 2.0, paddy Propylhomoserin sodium 2.0, inositol 2.0；
The preservative is made of, specifically potassium sorbate, dehydroactic acid sodium and potassium cinnamate：Potassium sorbate 0.1, dehydrogenation Sodium acetate 0.2, potassium cinnamate 0.1；
Embodiment 7
The auristilla product for the treatment of otitis and ear function of feeling well with clear ear that the present embodiment is provided, preparation method is substantially the same as real Example 1 is applied, only adjustment member formula is as follows：
The auristilla is liquor, and the total mass concentration of effective ingredient is 16%, and surplus is water, adjusts pH=5.5；It is each in effective ingredient Composition is in terms of mass fraction, specially：
The natural anti-inflammatory bacteriostatic agent, is made of, specifically Nantural non-toxic Chinese herbal medicine alcohol extract：Nantural non-toxic Chinese herbal medicine alcohol extracting Liquid 40.0；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 4.0, VB2 0.03, niacinamide 8.0, VB5 4.0, VB6 4.0, niacin 4.0；Biotin 0.06；
The cell-protecting, is made of allantoin, specifically：Allantoin 1.5；
The cellular agonist, is made of cromoci, specifically：Cromoci 4.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of VB12, specifically：VB12 8.0；
The intelligence hardening agent is zinc gluconate, specifically：Zinc gluconate 3.0；
The antioxidant is taurine；Specifically：Taurine 4.0；
The required agent of cell normal growth metabolism, is made of, specifically inositol：Inositol 4.0；
The preservative, is made of potassium sorbate, specifically：Potassium sorbate 1.5.
The test evaluation method of reference implementation example 1 selects 140 ages 20-65 Sui at random, the course of disease -10 years 2 days is made a definite diagnosis The volunteer that differs of otitis severity, 7 groups, every group of 20 volunteers, respectively prepared by Application Example 1 ~ 7 are set Auristilla product carries out drop ear experiment.
Usage：The liquid outlet of auristilla is directed at duct, instilled in ear, a moment is massaged after drop by cephalomenia side；Dosage：1-3 Drop/time, 1-3 times/day.Efficacy evaluation is carried out after 2 months on probation.
Statistical result shows that auristilla effect prepared by embodiment 1 is best, total effective rate 100.0%（P<0.05）；It is real The auristilla effect for applying the preparation of example 2 is worst, total effective rate 60.0%（P<0.05）；It is other to be followed successively by：
The total effective rate of embodiment 3 is 95.0%（P<0.05）；The total effective rate of embodiment 4 is 90.0%（P<0.05）；
The total effective rate of embodiment 5 is 85.0%（P<0.05）；The total effective rate of embodiment 6 is 75.0%（P<0.05）；
The total effective rate of embodiment 7 is 65.0%（P<0.05）.
Embodiment 8
The auristilla product for the treatment of otitis and ear function of feeling well with clear ear that the present embodiment is provided, preparation method is substantially the same as real Example 1 is applied, only adjustment member formula is as follows：
The auristilla is liquor, and the total mass concentration of effective ingredient is 8%, and surplus is water, adjusts pH=5.0；It is each in effective ingredient Composition is in terms of mass fraction, specially：
The natural anti-inflammatory bacteriostatic agent, is carried by Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica Object, menthol and peppermint oil is taken to constitute, specifically：Nantural non-toxic Chinese herbal medicine alcohol extract 40.0, Honegsukle flower P.E 5.0, chrysanthemum Flower extract 3.0, Angelica Dahurica extract 3.0, menthol 5.0, peppermint oil 3.0；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 0.2, VB2 0.8, niacinamide 0.01, VB5 0.01, VB6 0.01, niacin 0.01, Vc 0.01, Ve 0.001；
Biotin 1.0, Co-Q10 0.001, Coenzyme I 2.0, Coenzyme I I 2.0；
The cell-protecting, is made of trehalose and allantoin, specifically：Trehalose 0.01, allantoin 2.0；
The cellular agonist is made of, specifically ATP disodiums and cromoci：ATP disodiums 5.0 and cromoci 0.001；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically：Notogineng Extract 4.0, notoginseng total saponin/glycosides 2.0, VB12 0.01；
The intelligence hardening agent is zinc gluconate, specifically：Zinc gluconate 4.0；
The antioxidant is taurine；Specifically：Taurine 5.0；
The required agent of cell normal growth metabolism, is made of, specifically amino acids and inositol：Arginine 5.0, serine 5.0, glycine 9.0, glutamic acid 1.0, inositol 6.0；
The preservative, is made of potassium sorbate and dehydroactic acid sodium, specifically：Potassium sorbate 2.0, dehydroactic acid sodium 0.01。
Embodiment 9
The auristilla product for the treatment of otitis and ear function of feeling well with clear ear that the present embodiment is provided, preparation method is substantially the same as real Example 1 is applied, only adjustment member formula is as follows：
The auristilla is liquor, and the total mass concentration of effective ingredient is 8%, and surplus is water, adjusts pH=5.0；It is each in effective ingredient Composition is in terms of mass fraction, specially：
The natural anti-inflammatory bacteriostatic agent, is carried by Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica Object, menthol and peppermint oil is taken to constitute, specifically：Nantural non-toxic Chinese herbal medicine alcohol extract 70.0, Honegsukle flower P.E 7.0, chrysanthemum Flower extract 4.0, Angelica Dahurica extract 4.0, menthol 4.0, peppermint oil 4.0；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 6.0, VB2 1.0, niacinamide 10.0, VB5 6.0, VB6 6.0, niacin 5.0, Vc 5.0, Ve 1.0；
Biotin 0.001, Co-Q10 1.0, Coenzyme I 0.001, Coenzyme I I 0.001；
The cell-protecting, is made of trehalose and allantoin, specifically：Trehalose 9.0, allantoin 0.001；
The cellular agonist is made of, specifically ATP disodiums and cromoci：ATP disodiums 0.01 and cromoci 5.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically：Notogineng Extract 1.0, notoginseng total saponin/glycosides 0.001, VB12 10.0；
The intelligence hardening agent is zinc gluconate, specifically：Zinc gluconate 0.01；
The antioxidant is taurine；Specifically：Taurine 0.01；
The required agent of cell normal growth metabolism, is made of, specifically amino acids and inositol：
Arginine 0.001, serine 0.001, glycine 0.001, glutamic acid 0.001, inositol 0.01；
The preservative, is made of potassium sorbate and dehydroactic acid sodium, specifically：Potassium sorbate 0.01, dehydroactic acid sodium 2.0。
The test evaluation method of reference implementation example 1 selects -12 years 1 week 80 ages 20-66 Sui, the course of disease ears made a definite diagnosis at random 2 groups are arranged in the volunteer that scorching severity differs, and every group of 40 volunteers, Application Example 8, embodiment 9 are made respectively Standby different ratio but the auristilla product of identical mass percentage concentration carry out drop ear experiment.
Usage：The liquid outlet of auristilla is directed at duct, instilled in ear, a moment is massaged after drop by cephalomenia side；Dosage：1-3 Drop/time, 1-3 times/day.Efficacy evaluation is carried out after 2 months on probation.
Statistical result shows that auristilla effect prepared by embodiment 9 is best, total effective rate 95.0%（P<0.05）, implement Auristilla effect prepared by example 8 is weaker than embodiment 9, total effective rate 82.5%（P<0.05）.
Based on the above embodiments and the statistics of prolonged application effect shows that the present invention has following advantageous effect more outstanding：
（1）Clearing heat and detoxicating with antibacterial anti-inflammatory, clear ear is felt well ear, and sterilizing and itch-relieving is promoting blood circulation and removing obstruction in channels, and dispelling wind is had one's ideas straightened out, and removes necrosis and promote granulation, and is resisted Scorching anti-anaphylaxis and other effects.This product is different from conventional medicament, and typical feature is：Has a broad antifungal spectrum, it is with obvious effects；There is disease that can disappear, it is ill-mannered It can prevent；Automatically it oozes, it is easy to use；It is nontoxic, it is safe and efficient.
（2）The treatment and prevention of the symptoms such as otitis caused by many reasons, ear itching, otalgia are not only can be widely used for, also The apparent effect mitigated or alleviate tinnitus symptom.
（3）It is safe, it is widely applicable.Auristilla of the present invention has no toxic side effect, is non-stimulated, without allergy, is suitable for almost All groups.And it is quick, and can be used for a long time.
（4）Auristilla of the present invention not only has the function for the treatment of the ears disease such as otitis, be alternatively arranged as the children that there is no ear to suffer from and Daily ear health treatment of the normal adult for the refreshing ear of clear ear, with significant Nutritional Nursing Care ear brain and the work(for keeping ear pleasant Effect.In implementation " Health China strategy " process of construction, auristilla of the present invention will be made important for the maintenance of the ear brain health of people Contribution.
（5）Auristilla of the present invention may determine that the health status of ear；It is dropped in healthy duct, is not had abnormal sense Feel, penetrating comfort sense of only clearly soothing the spirit；If dropping in otitis tinnitus patient ear, there are treatment and mitigation, after instillation The feeling that sensible, inflammation of releiving mitigates is had, otitis tinnitus is more serious, and sensible sense of releiving is more apparent.

Claims (10)

1. a kind for the treatment of otitis and the auristilla for ear function of feeling well with clear ear, it is characterised in that：The auristilla includes natural anti-inflammatory Bacteriostatic agent, cell physiological function regulator, cell-protecting, cellular agonist, promoting blood circulation and removing obstruction in channels dose, it is intelligence hardening agent, anti-oxidant Agent, the required agent of cell normal growth metabolism；
The natural anti-inflammatory bacteriostatic agent, including but not limited to Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extraction Object, Angelica Dahurica extract, menthol, peppermint oil select one of which or several arbitrary proportion mixtures；
The cell physiological function regulator makees the physiological function of the relevant soma of ear organ with important adjusting With being made of vitamins and coenzyme substance；
The cell-protecting, including but not limited to trehalose, allantoin select one of which or the mixing of several arbitrary proportions Object；
The cellular agonist, including but not limited to ATP disodiums, cromoci select one of which or several arbitrary proportions mixed Close object；
Described promoting blood circulation and removing obstruction in channels dose, including but not limited to Notogineng Extract, notoginseng total saponin/glycosides, VB12 select one of which or several Kind arbitrary proportion mixture；
The intelligence hardening agent, including but not limited to zinc gluconate, zinc lactate, zinc citrate select one of which or several Arbitrary proportion mixture；
The antioxidant, including but not limited to taurine, VC sodium, phytic acid, phytate select one of which or several arbitrary ratios Example mixture；
The required agent of cell normal growth metabolism, including but not limited to amino acids, lactic acid class, inositol, select one of which Or several arbitrary proportion combinations.
2. the auristilla for the treatment of otitis and ear function of feeling well with clear ear as described in claim 1, which is characterized in that the auristilla packet Include preservative；The preservative, including but not limited to potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate, One of which or several arbitrary proportion mixtures may be selected in propionate.
3. auristilla as described in claim 1, it is characterised in that：The auristilla is liquor, the total mass concentration of effective ingredient For 0.5-20.0%, surplus is solvent；Each composition is in terms of mass fraction in effective ingredient, specially：
The natural anti-inflammatory bacteriostatic agent, is carried by Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica Object, menthol and peppermint oil is taken to constitute, specifically：Nantural non-toxic Chinese herbal medicine alcohol extract 1.0-80.0, Honegsukle flower P.E 0.01-9.0, chrysanthemum extract 0.01-6.0, Angelica Dahurica extract 0.01-6.0, menthol 0.01-10.0, peppermint oil 0.01- 6.0；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 0.01-6.0, vitamin V B2 0.001-1.0, niacinamide 0.01-10.0, VB5 0.01-6.0, VB6 0.01-6.0, niacin 0.01-5.0, Vc 0.01-5.0, Ve 0.001-1.0；
Biotin 0.001-1.0, Co-Q10 0.001-1.0, Coenzyme I 0.001-2.0, Coenzyme I I 0.001-2.0；
The cell-protecting, is made of trehalose and allantoin, specifically：Trehalose 0.01-9.0, allantoin 0.001- 2.0；
The cellular agonist is made of, specifically ATP disodiums and cromoci：ATP disodiums 0.01-5.0, cell color Plain C 0.001-5.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically：Notogineng Extract 0.01-10.0, notoginseng total saponin/glycosides 0.001-2.0, VB12 0.01-10.0；
The intelligence hardening agent, be zinc gluconate, zinc lactate, zinc citrate, specifically：Zinc gluconate 0.01-4.0, Zinc lactate 0.01-4.0, zinc citrate 0.01-4.0；
The antioxidant is taurine, VC sodium, phytic acid, phytate；Specifically：Taurine 0.01-5.0, VC sodium 0.01- 5.0, phytic acid 0.01-5.0, phytate 0.01-5.0；
The required agent of cell normal growth metabolism, is made of, specifically amino acids, lactic acid class and inositol：
Arginine 0.001-5.0, serine 0.001-5.0, glycine 0.001-9.0, glutamic acid 0.001-1.0, glutamine 0.01-8.0, lactic acid 0.01-5.0, sodium lactate 0.01-5.0, sodium glutamate 0.01-3.0；Inositol 0.01-6.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body：It is potassium sorbate 0.01-2.0, dehydroactic acid sodium 0.01-2.0, potassium cinnamate 0.01-2.0, glycyrrhizic acid 0.01-1.0, sweet Oxalates 0.01-3.0, propionate 0.01-2.0.
4. auristilla according to claim 3, it is characterised in that：The auristilla is liquor, the gross mass of effective ingredient A concentration of 1.0-18.0%, surplus are water；Each composition is in terms of mass fraction in effective ingredient, specially：
The natural anti-inflammatory bacteriostatic agent, is carried by Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica Object, menthol and peppermint oil is taken to constitute, specifically：Nantural non-toxic Chinese herbal medicine alcohol extract 2.0-76.0, Honegsukle flower P.E 0.01-8.0, chrysanthemum extract 0.01-5.0, Angelica Dahurica extract 0.01-5.0, menthol 0.01-8.0, peppermint oil 0.01- 5.0；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 0.01-5.0, vitamin V B2 0.001-0.5, niacinamide 0.01-8.0, VB5 0.01-5.0, VB6 0.01-5.0, niacin 0.01-4.0, Vc 0.01-4.0, Ve 0.01-1.0；Biotin 0.001-0.60, Co-Q10 0.01- 1.0, Coenzyme I 0.01-1.20, Coenzyme I I 0.01-1.60；
The cell-protecting, is made of trehalose and allantoin, specifically：Trehalose 0.01-6.0, allantoin 0.01- 1.0；
The cellular agonist is made of, specifically ATP disodiums and cromoci：ATP disodiums 0.01-4.0, cell color Plain C 0.01-4.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically：Notogineng Extract 0.01-8.0, notoginseng total saponin/glycosides 0.01-1.80, VB12 0.01-8.0；
The intelligence hardening agent, be zinc gluconate, zinc lactate, zinc citrate, specifically：Zinc gluconate 0.01-3.0, Zinc lactate 0.01-3.0, zinc citrate 0.01-3.0；
The antioxidant is taurine, VC sodium, phytic acid, phytate；Specifically：Taurine 0.01-4.0, VC sodium 0.01- 4.0, phytic acid 0.01-4.0, phytate 0.01-4.0；
The required agent of cell normal growth metabolism, is made of, specifically amino acids, lactic acid class and inositol：Arginine 0.001-4.0, serine 0.001-3.0, glycine 0.001-6.0, glutamic acid 0.01-1.0, glutamine 0.01-5.0, breast Sour 0.01-3.0, sodium lactate 0.01-4.0, sodium glutamate 0.01-2.0；Inositol 0.01-5.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body：Potassium sorbate 0.01-1.80, dehydroactic acid sodium 0.01-1.80, potassium cinnamate 0.01-1.80, glycyrrhizic acid 0.01- 0.80, glycyrrhetate 0.01-2.0, propionate 0.01-1.80.
5. having the auristilla for the treatment of otitis and the refreshing ear function of clear ear as claimed in claim 4, which is characterized in that the drop ear The total mass concentration of agent, effective ingredient is 7.0%；Each composition is in terms of mass fraction in effective ingredient, specially：
The natural anti-inflammatory bacteriostatic agent, is carried by Nantural non-toxic Chinese herbal medicine alcohol extract, Honegsukle flower P.E, chrysanthemum extract, the root of Dahurain angelica Object, menthol and peppermint oil is taken to constitute, specifically：Nantural non-toxic Chinese herbal medicine alcohol extract 40.0, Honegsukle flower P.E 5.0, chrysanthemum Flower extract 3.0, Angelica Dahurica extract 3.0, menthol 5.0, peppermint oil 3.0；
The cell physiological function regulator, is made of, specifically vitamins and coenzyme class：
Vitamin V B1 5.0, vitamin V B2 0.5, niacinamide 8.0, VB5 4.0, VB6 3.0, niacin 4.0, Vc 1.0, Ve 0.4；Biotin 0.6, Co-Q10 0.6, Coenzyme I 0.8, Coenzyme I I 0.9；
The cell-protecting, is made of trehalose and allantoin, specifically：Trehalose 4.5, allantoin 0.9；
The cellular agonist is made of, specifically ATP disodiums and cromoci：ATP disodiums 4.0 and cromoci 4.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically：Notogineng Extract 4.0, notoginseng total saponin/glycosides 0.6, VB12 8.0；
The intelligence hardening agent, be zinc gluconate, zinc lactate, zinc citrate, specifically：Zinc gluconate 2.0, zinc lactate 3.0, zinc citrate 1.0；
The antioxidant is taurine, VC sodium, phytic acid, phytate；Specifically：Taurine 1.0, VC sodium 2.0, phytic acid 2.0, phytate 2.0；
The required agent of cell normal growth metabolism, is made of, specifically amino acids, lactic acid class and inositol：
Arginine 4.0, serine 1.0, glycine 8.0, glutamic acid 0.9, glutamine 7.0, lactic acid 4.0, sodium lactate 4.0, paddy Propylhomoserin sodium 2.0, inositol 4.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, dipotassium glycyrrhizinate and sodium propionate, tool For body：Potassium sorbate 1.0, dehydroactic acid sodium 0.8, potassium cinnamate 0.8, glycyrrhizic acid 0.5, dipotassium glycyrrhizinate 2.0, sodium propionate 0.9.
6. having the application of the auristilla for the treatment of otitis and the refreshing ear function of clear ear as described in claim 1, which is characterized in that use Method is：In ear refreshing for otitis or clearly ear, auristilla is instilled by earhole in external auditory canal, is gently massaged by cephalomenia side A moment.
7. application of the auristilla as claimed in claim 6 in preparing treatment otitis and the refreshing ear function medicament of clear ear, feature exist In, in terms of dosage, 1-3 drops/time, 1-3 times/day；It is 0.02-0.04mL per drop volume.
8. the preparation method of the auristilla for the treatment of otitis and the refreshing ear function of clear ear as described in claim 1, which is characterized in that tool Body includes the following steps：
（1）Effective ingredient in auristilla is divided into 4 groups according to material properties and the convenience of preparation and easy property processed, weighs match respectively Dosage is spare in side, specifically：
First group, glycitols compound；
Second group, amino acids；
Third group, vitamin coenzymes class compound；
4th group, unclassified stores in addition to the solvents；
（2）By step（1）In second group of material weighing be placed in reaction kettle, the solvent of part formulation amount, stirring is then added Mixing is dissolved, is stood, mixture A is obtained after filtering and impurity removing；
（3）By step（1）In the third group that weighs and the 4th group of material be placed in reaction kettle, the molten of part formulation amount is then added Agent, stirring and dissolving mixing are stood, and mixture B is obtained after filtering and impurity removing；
（4）By step（3）Mixture B be slowly added into step（2）Mixture A in, after the completion of addition, be added step（1） In first group of material weighing, be eventually adding the solvent and auxiliary agent of remainder formula ratio, dissolving mixing, filtering and impurity removing are adjusted PH=3.5 ~ 7.5, this is auristilla product provided herein.
9. having the preparation method of the auristilla for the treatment of otitis and the refreshing ear function of clear ear as claimed in claim 8, which is characterized in that Step（2）, step（3）, step（4）In carry out dissolving mixing operation when, operation temperature be not higher than 45 DEG C, be not less than 10 DEG C.
10. the Nantural non-toxic Chinese herbal medicine alcohol extract in natural anti-inflammatory bacteriostatic agent as described in claim 1,3,4,5,8, feature It is, the component that the Nantural non-toxic Chinese herbal medicine alcohol extract contains following mass fraction is simultaneously made by following processes：Gold 30~90 parts of honeysuckle flower, 40~80 parts of chrysanthemum, 40~75 parts of licorice, 40~75 parts of pueraria lobata, 40~75 parts of Radix Salviae Miltiorrhizae, Radix Astragali 20~55 Part, 30~60 parts of Radix Notoginseng, 10~50 parts of Radix Angelicae Sinensis, windproof 30~70 parts, 15~70 parts of schizonepeta, 20~80 parts of peppermint, the root of Dahurain angelica 15~ 50 parts, 15~50 parts of akebi, 15~90 parts of Centipeda minima；Its process of preparing includes：The formula Chinese medicine is weighed, is crushed to Grain size is the particle of grain of rice size, and a concentration of 10-90% for being equivalent to 5-20 times of quality of mixture is added（V/V）Ethyl alcohol, then More than a few hours extracting solution is collected by filtration up to described in extraction under the conditions of set temperature is 20-105 DEG C in multi-functional extractor Alcohol extract.
CN201810853764.3A 2018-07-30 2018-07-30 It is a kind of to treat otitis and the auristilla and preparation method thereof for ear function of feeling well with clear ear Pending CN108635572A (en)

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