CN108635407A - For the compound essential oil composition of cold, fever, preparation and its preparation method and application - Google Patents
For the compound essential oil composition of cold, fever, preparation and its preparation method and application Download PDFInfo
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Abstract
The present invention provides a kind of compound essential oil compositions for cold, fever,Preparation and its preparation method and application,It is related to functional essential oil technical field,This is used for the compound essential oil composition of cold, fever mainly by radix bupleuri essential oil,Windproof essential oil,Rhizoma Et Radix Notopterygii essential oil,Peppermint essential oil,Schizonepeta essential oil,Lavender and chamomile essential oil composition,By said components be prepared for dosage forms such as the compound essential oil composition of cold, fever and its patches that further prepares,All have significant effect of bringing down a fever,Fragrant odour,It makes simple,Advantage easy to use,Without any toxicity and side effects compared to existing anti-cold and abating fever Western medicine,It is green and healthy,The side effect of oral medication is avoided simultaneously,Percutaneous absorption biological availability greatly improves,It is big that existing anti-cold and abating fever Western medicine toxic side effect has been effectively relieved,It is of high cost,It is also easy to produce drug resistance and takes inconvenient problem.
Description
Technical field
The present invention relates to functional essential oil technical fields, are combined more particularly, to a kind of compound essential oil for cold, fever
Object, preparation and its preparation method and application.
Background technology
Flu refers to one kind in infection of the upper respiratory tract disease, show as nasal obstruction, runny nose, sneeze, headache, aversion to cold, fever,
The clinical symptoms such as general malaise.Currently, being the Western medicine of symptomatic treatment, such as compound Ah Si for most for the treatment of cold-treating preparation
The Tri-Biocins such as woods, paracetamol, Indomethacin and penicillin, cephalosporin, macrolides or quinolones
Object.These Western medicine often toxic side effect it is big, it is of high cost, be also easy to produce drug resistance and take it is also more inconvenient.
Essential oil is in the flower from plant, leaf, stem, root or fruit, passes through steam distillation, extrusion, cold-maceration or molten
Agent extraction method refines the volatile flavor of extraction.Essential oil has lipophilicity, so being easy to infiltration in skin, by means of skin
Abundant capillary under lower fat and enter it is internal, to play the effect for improving local organization metabolism.It is usually used in killing
Bacterium is anti-inflammatory, improves skin, toxin expelling, pleasure mood etc..
Therefore, in view of the above-mentioned problems, researching and developing one kind safely and effectively, of low cost while easy to use is used to feel
Emit the compound essential oil composition of fever, alleviate existing anti-cold and abating fever Western medicine toxic side effect it is big, it is of high cost, be also easy to produce drug resistance and
Inconvenient problem is taken, becomes very necessary and urgent.
In view of this, special propose the present invention.
Invention content
The first object of the present invention is to provide a kind of compound essential oil composition for cold, fever, described for catching a cold
The compound essential oil composition of fever is brought down a fever significant effect, fragrant odour, make it is simple, it is easy to use, moved back compared to existing anti-sense
Hot Western medicine is without any toxicity and side effects, green and healthy, while avoiding the side effect of oral medication, and percutaneous absorption biological availability is significantly
Improve, be effectively relieved existing anti-cold and abating fever Western medicine toxic side effect it is big, it is of high cost, be also easy to produce drug resistance and take inconvenient ask
Topic.
The second object of the present invention is to provide a kind of system that the compound essential oil composition for cold, fever is prepared
Agent, said preparation have many advantages, such as to can be made into a variety of dosage forms.
The third object of the present invention is to provide a kind of preparation method of preparation, and this method technological process is simple, prepares
Special process equipment is not needed in journey, is suitble to large-scale industrial production and with economical well.
The fourth object of the present invention is to provide a kind of compound essential oil composition for cold, fever and its is prepared
Preparation application, which can be widely applied to prepare
In the external preparation for treating cold, fever symptom.
A kind of compound essential oil composition for cold, fever provided by the invention, is counted in parts by weight, described for feeling
The compound essential oil composition for emitting fever is mainly made of the following raw material：3~25 parts of radix bupleuri essential oil, 2~15 parts of windproof essential oil, Rhizoma Et Radix Notopterygii
1~10 part of essential oil, 2~15 parts of Peppermint essential oil, 1~10 part of schizonepeta essential oil, 2~15 parts of Lavender and chamomile essential oil 1~
10 parts.
Further, it counts in parts by weight, the compound essential oil composition for cold, fever is mainly by the following raw material
It is made：8~20 parts of radix bupleuri essential oil, 4~14 parts of windproof essential oil, 2~8 parts of Rhizoma Et Radix Notopterygii essential oil, 4~14 parts of Peppermint essential oil, schizonepeta essential oil 2
2~8 parts of~8 parts, 4~14 parts of Lavender and chamomile essential oil.
Further, it counts in parts by weight, the compound essential oil composition for cold, fever is mainly by following former
Material is made：12~18 parts of radix bupleuri essential oil, 8~12 parts of windproof essential oil, 4~6 parts of Rhizoma Et Radix Notopterygii essential oil, 8~12 parts of Peppermint essential oil, schizonepeta essence
4~6 parts of 4~6 parts of oil, 8~12 parts of Lavender and chamomile essential oil；
Preferably, it counts in parts by weight, the compound essential oil composition for cold, fever is mainly by the following raw material system
At：15 parts of radix bupleuri essential oil, 10 parts of windproof essential oil, 5 parts of Rhizoma Et Radix Notopterygii essential oil, 10 parts of Peppermint essential oil, 5 parts of schizonepeta essential oil, Lavender
10 parts and 5 parts of chamomile essential oil.
Further, the radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii essential oil, Peppermint essential oil, schizonepeta essential oil, Lavender
It is made by natural purpose plant extract with chamomile essential oil；
Preferably, the extracting method is carbon dioxide supercritical extraction method, steam distillation or physical squeezing extraction
Method.
The preparation that a kind of above-mentioned compound essential oil composition for cold, fever provided by the invention is prepared.
Further, the dosage form of the preparation is any one in finish, patch, suppository, paste or gelling agent.
A kind of preparation method of above-mentioned preparation provided by the invention, the preparation method include being used for cold, fever by above-mentioned
Compound essential oil composition and pharmaceutically acceptable auxiliary material be processed into preparation.
Further, the preparation method of the finish includes the following steps：
By radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii essential oil, Peppermint essential oil, schizonepeta essential oil, Lavender and chamomile essential oil
It is added sequentially among base plants oil, is then sufficiently stirred mixing, finish preparation is made；
Preferably, the weight ratio of the compound essential oil composition for cold, fever and base plants oil is 1：5~10；
It is furthermore preferred that the base plants oil is one in Sweet Almond Oil, grape seed oil, SIMMONDSIA CHINENSIS SEED OIL, wheat-germ oil
Kind.
Further, the preparation method of the patch includes the following steps：
By for the compound essential oil composition of cold, fever with thickening matrix with 1：1~2 volume ratio mixing then heats
20~30min of stirring obtains the semisolid fluid of sticky shape, and semisolid fluid is coated on aluminium foil with the thickness of 0.3~0.8mm
On back sheet, it is placed at room temperature for 10~15min solidifications and volatilizes, then cover eva film and adhesion layer and seal, obtain patch system
Agent；
Preferably, the thickening matrix is one kind in carbomer, HPMC, PVA, PEG, hexadecanol or propylene glycol.
A kind of above-mentioned compound essential oil composition for cold, fever provided by the invention or above-mentioned preparation are caught a cold improving
Application in heating paresthesia.
Compared with prior art, beneficial effects of the present invention are：
Provided by the present invention for cold, fever compound essential oil composition mainly by radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii
Essential oil, Peppermint essential oil, schizonepeta essential oil, Lavender and chamomile essential oil composition.Above-mentioned the answering for cold, fever of the present invention
Square essential oil composition under the basis that traditional Chinese medicine compatibility theory and essential oil blending technology are combined, with it is antipyretic, bring down a fever, calm, town
Bitterly, the radix bupleuri essential oil of antibacterial be monarch drug in a prescription, be equipped with expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, relieving convulsion the effect of windproof essential oil, cold dispelling expelling pathogenic factors from muscles and skin,
Wind-dispelling dampness elimination, numbness relieving and pain relieving Rhizoma Et Radix Notopterygii essential oil, cure cold fever laryngalgia Peppermint essential oil, the schizonepeta essential oil for the promoting eruption that expels pathogenic wind from the body surface,
Assistant with clearing heat and detoxicating, calm, antibacterial anti-inflammatory lavender and analgesic, antiallergy, antiemetic, ventosity of dispelling, calm sharp spleen of bringing down a fever,
It is to make medicine to urge the chamomile essential oil of sweat.It is brought down a fever effect by the compound essential oil composition for cold, fever that said components are prepared
Fruit is notable, fragrant odour, makes simply, easy to use, and without any toxicity and side effects compared to existing anti-cold and abating fever Western medicine, green is strong
Health, while the side effect of oral medication is avoided, percutaneous absorption biological availability greatly improves, and existing anti-sense has been effectively relieved and has moved back
Hot Western medicine toxic side effect is big, it is of high cost, be also easy to produce drug resistance and take inconvenient problem.
The preparation that the above-mentioned compound essential oil composition for cold, fever provided by the invention is prepared, said preparation are brought down a fever
Significant effect, fragrant odour, meanwhile, also have many advantages, such as to can be made into a variety of dosage forms.
The preparation method of preparation provided by the invention, the preparation method include by the above-mentioned compound essence for cold, fever
Fluid composition and pharmaceutically acceptable auxiliary material are processed into preparation.The preparation method is simple with preparation, simple operation, can make
The advantages that at a variety of dosage forms.This method utmostly remains the medicinal efficacy of each medicinal material, realizes treatment conveniently, drug effect is long
Long, the advantages that preparation can be carried around, and curative effect is stablized, and preparation economy is strong.
It can be widely applied to prepare provided by the present invention for the compound essential oil composition or above-mentioned preparation of cold, fever
In the external preparation for improving cold, fever symptom.
Specific implementation mode
Technical scheme of the present invention is clearly and completely described below in conjunction with embodiment, it is clear that described reality
It is a part of the embodiment of the present invention to apply example, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
The every other embodiment that art personnel are obtained without making creative work belongs to the model that the present invention protects
It encloses.
According to an aspect of the present invention, a kind of compound essential oil composition for cold, fever, is counted, institute in parts by weight
It states and is mainly made of the following raw material for the compound essential oil composition of cold, fever：3~25 parts of radix bupleuri essential oil, windproof essential oil 2~
15 parts, 1~10 part of Rhizoma Et Radix Notopterygii essential oil, 2~15 parts of Peppermint essential oil, 1~10 part of schizonepeta essential oil, 2~15 parts of Lavender and ocean are sweet
1~10 part of chrysanthemum essential oil.
Each raw material of the present invention is act as played in above-mentioned anti-cold and abating fever compounding essential oil：
Radix bupleuri essential oil is the ingredient that radix bupleuri goes out by water distillation or subcritical low-temperature extraction, and radix bupleuri has in inducing diaphoresis, dredges
Liver solution is strongly fragrant, yang invigorating, bring down a fever preventing malaria the effect of, essential oil prepared therefrom have it is antipyretic, bring down a fever, calm, analgesia, antibacterial, in advance
Anti- anti-liver injury and antiviral effect.In the present invention, above-mentioned radix bupleuri essential oil is typical but non-limiting parts by weight are：3 parts,
5 parts, 8 parts, 10 parts, 15 parts, 18 parts, 20 parts and 25 parts.
Windproof essential oil is the windproof ingredient gone out by water distillation or subcritical low-temperature extraction, is had by the essential oil of windproof preparation
It expels pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, the effect of relieving convulsion.In the present invention, above-mentioned windproof essential oil is typical but non-limiting parts by weight are：
2 parts, 5 parts, 8 parts, 10 parts, 12 parts and 15 parts.
Rhizoma Et Radix Notopterygii essential oil is the ingredient that Rhizoma Et Radix Notopterygii goes out by water distillation or subcritical low-temperature extraction, and Rhizoma Et Radix Notopterygii has cold dispelling expelling pathogenic factors from muscles and skin, dispels
The effect of weathering is wet, numbness relieving and pain relieving, essential oil prepared therefrom can be used for catching cold, is headache and adiapneustia, cold-dampness numbness, upper limb arthritis pain
The diseases such as pain.In the present invention, above-mentioned Rhizoma Et Radix Notopterygii essential oil is typical but non-limiting parts by weight are：1 part, 2 parts, 4 parts, 6 parts, 8 parts and
10 parts.
Peppermint essential oil is the ingredient that peppermint goes out by water distillation or subcritical low-temperature extraction, and peppermint is labiate, is used
In controlling influenza fever laryngalgia, have a headache, conjunctival congestion with ophthalmalgia, myalgia, itchy skin with rubella, the diseases such as measles without adequate eruption.The present invention
In, above-mentioned Peppermint essential oil is typical but non-limiting parts by weight are：2 parts, 5 parts, 8 parts, 10 parts, 12 parts and 15 parts.
Schizonepeta essential oil is the ingredient that schizonepeta goes out by water distillation or subcritical low-temperature extraction, and schizonepeta is inducing sweat and dispelling exogenous evils preparation,
Essential oil prepared therefrom can be used for influenza, headache fever and chills sweating, the diseases such as vomiting.In the present invention, above-mentioned schizonepeta essential oil is typical
But non-limiting parts by weight are：1 part, 2 parts, 4 parts, 6 parts, 8 parts and 10 parts.
Lavender is the ingredient that lavender goes out by water distillation or subcritical low-temperature extraction, and lavender has significant
The biological actions such as antibacterial, anti-oxidant, essential oil prepared therefrom has the function of clearing heat and detoxicating, calm, antibacterial anti-inflammatory；This
In invention, above-mentioned Lavender is typical but non-limiting parts by weight are：2 parts, 5 parts, 8 parts, 10 parts, 12 parts and 15 parts.
Chamomile essential oil is the ingredient that chamomile goes out by water distillation or subcritical low-temperature extraction, and chamomile is that composite family is planted
Object, mildly bitter flavor, Gan Xiang.With improving eyesight, move back irascibility, treatment insomnia, the effect of reducing blood pressure.In chamomile essential oil containing sobrerone,
The substances such as firpene, amphene, sabinene, laurene, cineole and China pink (terpene) alkene can alleviate anxiety, anxiety, indignation and fear, make
People, which loosens, patience, feels happy and auspicious.In the present invention, above-mentioned chamomile essential oil is typical but non-limiting parts by weight are：1 part, 2
Part, 4 parts, 6 parts, 8 parts and 10 parts.
Provided by the present invention for cold, fever compound essential oil composition mainly by radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii
Essential oil, Peppermint essential oil, schizonepeta essential oil, Lavender and chamomile essential oil composition.Above-mentioned the answering for cold, fever of the present invention
Square essential oil composition under the basis that traditional Chinese medicine compatibility theory and essential oil blending technology are combined, with it is antipyretic, bring down a fever, calm, town
Bitterly, the radix bupleuri essential oil of antibacterial be monarch drug in a prescription, be equipped with expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, relieving convulsion the effect of windproof essential oil, cold dispelling expelling pathogenic factors from muscles and skin,
Wind-dispelling dampness elimination, numbness relieving and pain relieving Rhizoma Et Radix Notopterygii essential oil, cure cold fever laryngalgia Peppermint essential oil, the schizonepeta essential oil for the promoting eruption that expels pathogenic wind from the body surface,
Assistant with clearing heat and detoxicating, calm, antibacterial anti-inflammatory lavender and analgesic, antiallergy, antiemetic, ventosity of dispelling, calm sharp spleen of bringing down a fever,
It is to make medicine, then be aided with oil based on Sweet Almond Oil or SIMMONDSIA CHINENSIS SEED OIL or grape seed oil or wheat-germ oil to urge the chamomile essential oil of sweat
Compound essential oil composition.It is shown by the compound essential oil composition for cold, fever that said components are prepared effect of bringing down a fever
It writes, fragrant odour, makes simply, it is easy to use, it is without any toxicity and side effects compared to existing anti-cold and abating fever Western medicine, green and healthy, together
When avoid the side effect of oral medication, percutaneous absorption biological availability greatly improves.
In the preferred embodiment of the present invention, it counts in parts by weight, the compound essential oil for cold, fever
Composition is mainly made of the following raw material：8~20 parts of radix bupleuri essential oil, 4~14 parts of windproof essential oil, 2~8 parts of Rhizoma Et Radix Notopterygii essential oil, peppermint
2~8 parts of 4~14 parts of essential oil, 2~8 parts of schizonepeta essential oil, 4~14 parts of Lavender and chamomile essential oil.
It in above-mentioned preferred embodiment, counts in parts by weight, the compound essential oil for cold, fever combines owner
It to be made of the following raw material：12~18 parts of radix bupleuri essential oil, 8~12 parts of windproof essential oil, 4~6 parts of Rhizoma Et Radix Notopterygii essential oil, Peppermint essential oil 8~
4~6 parts of 12 parts, 4~6 parts of schizonepeta essential oil, 8~12 parts of Lavender and chamomile essential oil；
Preferably, it counts in parts by weight, the compound essential oil composition for cold, fever is mainly by the following raw material system
At：15 parts of radix bupleuri essential oil, 10 parts of windproof essential oil, 5 parts of Rhizoma Et Radix Notopterygii essential oil, 10 parts of Peppermint essential oil, 5 parts of schizonepeta essential oil, Lavender
10 parts and 5 parts of chamomile essential oil.
In the present invention, by the further adjustment and optimization to each component raw material dosage ratio, to advanced optimize
Drug effect of the present invention for the compound essential oil composition of cold, fever.
In the preferred embodiment of the present invention, the above-mentioned compound essential oil composition for cold, fever further includes orange
1~10 part of 1~10 part of flower essential oil and lemon grass (Cymbopogon citratus) essential oil.
Flores aurantii essential oil is extracted from bigarabe white petal, is had calming nerves effect, is treated the benefit side of insomnia, can also change
Ormazd's dysmenorrhoea, have a headache and dazzle it is dizzy, the present invention for cold, fever compound essential oil composition in be added flores aurantii essential oil can be effective
Improve the symptom of the headache and dizziness of cold, fever patient.
Lemon grass (Cymbopogon citratus) essential oil is a kind of essential oil for extracting from lemon grass (Cymbopogon citratus), has extraordinary anti-depression, antibacterial, sterilizes, stomach of dispelling
Flatulence deodorization, helps digest, diuresis, killing fungus, lactagogue, insecticidal, prevents disease, excitation, benefit body and other effects.The present invention uses
It is dispirited can be effectively improved cold, fever patient's gold body for addition lemon grass (Cymbopogon citratus) essential oil in the compound essential oil composition of cold, fever
Symptom.
In the preferred embodiment of the present invention, the radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii essential oil, Peppermint essential oil,
Schizonepeta essential oil, Lavender and chamomile essential oil are made by natural purpose plant extract；
Preferably, the extracting method is carbon dioxide supercritical extraction method, steam distillation or physical squeezing extraction
Method.
As a preferred embodiment, above-mentioned each raw material essential oil is made by carbon dioxide supercritical extraction method.It answers
There is no dissolvent residual, active constituent not to pollute with the essential oil that carbon dioxide supercritical extraction method is prepared, effectively prevent heat
The oxidation and loss of quick property and substance effectively maintain whole effects of natural material during extraction.
According to an aspect of the present invention, a kind of system that the above-mentioned compound essential oil composition for cold, fever is prepared
Agent.
The preparation that the above-mentioned compound essential oil composition for cold, fever provided by the invention is prepared, effect of bringing down a fever are aobvious
It writes, fragrant odour, meanwhile, also have many advantages, such as to can be made into a variety of dosage forms.
In the preferred embodiment of the present invention, the dosage form of the preparation is finish, patch, suppository, paste or solidifying
Any one in jelly.
In above-mentioned preferred embodiment, the above-mentioned compound essential oil composition for cold, fever can be further processed into
One kind in finish, patch, suppository, paste or gelling agent, to realize that preparation uses more, the applied widely advantage of dosage form.
According to an aspect of the present invention, a kind of preparation method of above-mentioned preparation, the preparation method include by above-mentioned use
It is processed into preparation in the compound essential oil composition of cold, fever and pharmaceutically acceptable auxiliary material.
The preparation method of preparation provided by the invention, the preparation method include by the above-mentioned compound essence for cold, fever
Fluid composition and pharmaceutically acceptable auxiliary material are processed into preparation.The preparation method is simple with preparation, simple operation, can make
The advantages that at a variety of dosage forms.This method utmostly remains the medicinal efficacy of each medicinal material, realizes treatment conveniently, drug effect is long
Long, the advantages that preparation can be carried around, and curative effect is stablized, and preparation economy is strong.
In the preferred embodiment of the present invention, the preparation method of the finish includes the following steps：
By radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii essential oil, Peppermint essential oil, schizonepeta essential oil, Lavender and chamomile essential oil
It is added sequentially among base plants oil, is then sufficiently stirred mixing, finish preparation is made；
Preferably, the weight ratio of the compound essential oil composition for cold, fever and base plants oil is 1：5~10；
It is furthermore preferred that the base plants oil is one in Sweet Almond Oil, grape seed oil, SIMMONDSIA CHINENSIS SEED OIL, wheat-germ oil
Kind.
In the preferred embodiment of the present invention, the preparation method of the patch includes the following steps：
By anti-cold and abating fever essential oil composition with thickening matrix with 1：1~2 volume ratio mixing, subsequent heating stirring 20~
30min obtains the semisolid fluid of sticky shape, and semisolid fluid is coated on the thickness of 0.3~0.8mm on aluminium foil back sheet,
It is placed at room temperature for 10~15min solidifications to volatilize, then covers eva film and adhesion layer and seal, obtain patch preparation；
Preferably, the thickening matrix is one kind in carbomer, HPMC, PVA, PEG, hexadecanol or propylene glycol.
According to an aspect of the present invention, a kind of above-mentioned to exist for the compound essential oil composition of cold, fever or above-mentioned preparation
Improve the application in cold, fever symptom.
Technical scheme of the present invention is described further below in conjunction with embodiment.
Embodiment 1
A kind of anti-cold and abating fever composite essential oil, is counted in parts by weight, and the anti-cold and abating fever composite essential oil is mainly by the following raw material
It is made：3 parts of radix bupleuri essential oil, 2 parts of windproof essential oil, 1 part of Rhizoma Et Radix Notopterygii essential oil, 2 parts of Peppermint essential oil, 1 part of schizonepeta essential oil, Lavender 15
1 part of part and chamomile essential oil and 900 parts of base plants oil.
The preparation method of above-mentioned anti-cold and abating fever composite essential oil includes the following steps：By radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii essence
Oil, Peppermint essential oil, schizonepeta essential oil, Lavender and chamomile essential oil are added sequentially among base plants oil, then fully
It stirs and evenly mixs, anti-cold and abating fever composite essential oil is made.
Embodiment 2
A kind of anti-cold and abating fever composite essential oil, is counted in parts by weight, and the anti-cold and abating fever composite essential oil is mainly by the following raw material
It is made：25 parts of radix bupleuri essential oil, 15 parts of windproof essential oil, 10 parts of Rhizoma Et Radix Notopterygii essential oil, 15 parts of Peppermint essential oil, 10 parts of schizonepeta essential oil, lavender
10 parts of 15 parts of essential oil and chamomile essential oil and 1000 parts of base plants oil.
Above-mentioned anti-cold and abating fever composite essential oil preparation method includes the following steps：By radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii essence
Oil, Peppermint essential oil, schizonepeta essential oil, Lavender and chamomile essential oil are added sequentially among base plants oil, then fully
It stirs and evenly mixs, anti-cold and abating fever composite essential oil is made.
Embodiment 3
A kind of anti-cold and abating fever composite essential oil, is counted in parts by weight, and the anti-cold and abating fever composite essential oil is mainly by the following raw material
It is made：8 parts of radix bupleuri essential oil, 4 parts of windproof essential oil, 2 parts of Rhizoma Et Radix Notopterygii essential oil, 4 parts of Peppermint essential oil, 2 parts of schizonepeta essential oil, Lavender 4
2 parts of part and chamomile essential oil and 920 parts of base plants oil.
The preparation method of above-mentioned anti-cold and abating fever composite essential oil includes the following steps：By radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii essence
Oil, Peppermint essential oil, schizonepeta essential oil, Lavender and chamomile essential oil are added sequentially among base plants oil, then fully
It stirs and evenly mixs, anti-cold and abating fever composite essential oil is made.
Embodiment 4
A kind of anti-cold and abating fever composite essential oil, is counted in parts by weight, and the anti-cold and abating fever composite essential oil is mainly by the following raw material
It is made：20 parts of radix bupleuri essential oil, 14 parts of windproof essential oil, 8 parts of Rhizoma Et Radix Notopterygii essential oil, 14 parts of Peppermint essential oil, 8 parts of schizonepeta essential oil, lavender essence
8 parts of 14 parts of oil and chamomile essential oil and 980 parts of base plants oil.
The preparation method of above-mentioned anti-cold and abating fever composite essential oil includes the following steps：By radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii essence
Oil, Peppermint essential oil, schizonepeta essential oil, Lavender and chamomile essential oil are added sequentially among base plants oil, then fully
It stirs and evenly mixs, anti-cold and abating fever composite essential oil is made.
Embodiment 5
A kind of anti-cold and abating fever composite essential oil, is counted in parts by weight, and the anti-cold and abating fever composite essential oil is mainly by the following raw material
It is made：15 parts of radix bupleuri essential oil, 10 parts of windproof essential oil, 5 parts of Rhizoma Et Radix Notopterygii essential oil, 10 parts of Peppermint essential oil, 5 parts of schizonepeta essential oil, lavender essence
950 parts of 10 parts of oil, 5 parts of chamomile essential oil, 5 parts of flores aurantii essential oil, 5 parts of lemon grass (Cymbopogon citratus) essential oil and base plants oil.
The preparation method of above-mentioned anti-cold and abating fever composite essential oil includes the following steps：By radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii essence
Oil, Peppermint essential oil, schizonepeta essential oil, Lavender, chamomile essential oil, flores aurantii essential oil and lemon grass (Cymbopogon citratus) essential oil are added sequentially to basis
Among vegetable oil, it is then sufficiently stirred mixing, anti-cold and abating fever composite essential oil is made.
Embodiment 6
A kind of anti-cold and abating fever patch, is counted in parts by weight, and the anti-cold and abating fever composite essential oil is mainly made of the following raw material：
15 parts of radix bupleuri essential oil, 10 parts of windproof essential oil, 5 parts of Rhizoma Et Radix Notopterygii essential oil, 10 parts of Peppermint essential oil, 5 parts of schizonepeta essential oil, Lavender 10
Part, 5 parts of chamomile essential oil, 5 parts of flores aurantii essential oil and 5 parts of lemon grass (Cymbopogon citratus) essential oil.
The preparation method of above-mentioned anti-cold and abating fever patch includes the following steps：
(a) by radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii essential oil, Peppermint essential oil, schizonepeta essential oil, Lavender, chamomile essence
Oil, flores aurantii essential oil and lemon grass (Cymbopogon citratus) essential oil mix successively, are then sufficiently stirred mixing, and anti-cold and abating fever composite essential oil is made.
(b) by anti-cold and abating fever composite essential oil and carbomer with 1：1 volume ratio mixing, subsequent heating stirring 25min are obtained
Semisolid fluid is coated on the thickness of 0.5mm on aluminium foil back sheet, is placed at room temperature for 12min by the semisolid fluid of sticky shape
Solidification volatilizes, and then covers eva film and adhesion layer and seals, and obtains anti-cold and abating fever composite essential oil patch.
1 anti-inflammatory experiment of experimental example --- the influence of paraxylene induced mice auricle edema
(1) animal subject：Kunming mouse, half male and half female, weight 20g ± 2g.
(2) laboratory apparatus, reagent：Card punch, electronic balance, syringe, dexamethasone sodium phosphate injection,
(3) test method：Healthy Kunming mouse 110 is taken, half male and half female is random to be grouped, control group, positive group, reality
The high, medium and low dosage groups of group 1-3 are tested, every group 10, are marked.Administration 3 days is smeared, twice daily, after the 3rd day end administration half an hour,
Dimethylbenzene, which is applied to auris dextra exterior feature two sides, causes inflammation, left ear to compare.After 1 hour, draws neck to put to death mouse, left and right ear is cut, with punching
Device is punched along left and right ear same area, and both sides auricle is weighed respectively, using left and right auricle weight difference as swelling, and calculates swelling
Inhibiting rate.
(4) preparation grouping and preparation method：
Control group：Distilled water
Western medicine group：Dexamethasone is injected intraperitoneally
Test group 1：Anti- cold and abating fever composite essential oil is prepared according to embodiment 1
Test group 2：Anti- cold and abating fever composite essential oil is prepared according to embodiment 2
Test group 3：Anti- cold and abating fever composite essential oil is prepared according to embodiment 3
(5) anti-inflammatory experimental result is as shown in table 1.
Table 1：The influence of paraxylene induced mice auricle edema
Note：Compared with the control group, * * P<0.01, * P<0.05
By above-mentioned experimental result it is found that compared with the control group, three groups of test groups of the invention can significantly inhibit dimethylbenzene institute
Cause mice auricle swelling；Inhibit dimethylbenzene induced mice auricle edema effect suitable with Western medicine group.The composition of three groups of experiments it
Between compare, the formula inhibition of experimental group 3 is good.
2 analgesic experiment of experimental example --- Dichlorodiphenyl Acetate causes the effect of mouse writhing reaction
(1) test method:Take healthy Kunming mouse 110, half male and half female is random to be grouped, control group, Western medicine group (Ah
Take charge of a woods, 0.2g/kg), the high, medium and low dosage groups of experimental group 1-3, every group 10, label.Administration 3 days is smeared, twice daily, the
After the last half an hour of administration in 3 days, intraperitoneal injection glacial acetic acid 0.2ml/ is only.With abdomen indent, buttocks is raised, and stretching, extension hind leg refers to for writhing
The number of interior writhing after acetic acid is injected in mark, observation, and calculates analgesia rate.
(2) preparation is grouped and the preparation method is the same as that of Example 1.
(3) analgesic effect the results are shown in Table 2：
2 Dichlorodiphenyl Acetate of table causes the effect of mouse writhing reaction
By above-mentioned experimental result it is found that compared with the control group, three groups of test groups of the invention can significantly inhibit Dichlorodiphenyl Acetate cause
The effect of mouse writhing reaction；It is suitable with Western medicine group analgesic effect.It is compared between the composition of three groups of experiments, experimental group 3 is matched
Square inhibition is good.
3 antipyretic effect of embodiment --- the influence of fever in rabbits is caused to bacterial endotoxin
(1) animal subject：Rabbit, 38.6~39.5 DEG C of body temperature, fluctuation are no more than 0.2 DEG C
(2) test method：The healthy rabbits 55 for taking body temperature qualification are divided into 11 groups by weight stratified random, every group 5,
Anus temperature is surveyed respectively 2 times, 30min is spaced, using mean value as its normal body temperature.It is orally according to dosage given respectively into rabbit stomach with catheter
Test group 1-3 senior middle schools low dosage, the animal filling of Western medicine group (aspirin), control group is in the distilled water of volume.Each group is in administration
After 1h, every rabbit presses the dosage bacterial injection endotoxin of 14 units/kg from auricular vein, and observation animal heat changes, every
30min surveys anus temperature 1 time, METHOD FOR CONTINUOUS DETERMINATION 6h, using normal body temperature before administration as radix, calculates the hundred of each minute rabbit Temperature changing
Divide rate.
(3) preparation is grouped and the preparation method is the same as that of Example 1.
(4) antipyretic effect the results are shown in Table 3.
Table 3：The influence of fever in rabbits is caused to bacterial endotoxin
Note：Compared with the control group, * * P<0.01, * P<0.05
By above-mentioned experimental result it is found that compared with the control group, three groups of test groups of the invention can be significantly inhibited in bacterium
Toxin causes the influence of fever in rabbits；High dose group and Western medicine group effect of bringing down a fever are suitable.It is compared between the composition of three groups of experiments, it is real
Test group 3 formula inhibition it is good, and high dose group bring down a fever it is better.
In conclusion provided by the present invention for cold, fever compound essential oil composition mainly by radix bupleuri essential oil, windproof
Essential oil, Rhizoma Et Radix Notopterygii essential oil, Peppermint essential oil, schizonepeta essential oil, Lavender, chamomile essential oil composition.The present invention is above-mentioned for catching a cold
The compound essential oil composition of fever under the basis that traditional Chinese medicine compatibility theory and essential oil blending technology are combined, with it is antipyretic, bring down a fever,
Calm, analgesia, antibacterial radix bupleuri essential oil be monarch drug in a prescription, be equipped with expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, relieving convulsion the effect of windproof essential oil, dissipate
Cold expelling pathogenic factors from muscles and skin, wind-dispelling dampness elimination, numbness relieving and pain relieving Rhizoma Et Radix Notopterygii essential oil, the Peppermint essential oil for the fever laryngalgia that cures cold, the chaste tree for the promoting eruption that expels pathogenic wind from the body surface
Mustard essential oil is helped with clearing heat and detoxicating, calm, antibacterial anti-inflammatory lavender and analgesic, antiallergy, antiemetic, ventosity of dispelling, town of bringing down a fever
Quiet profit spleen urges the chamomile essential oil of sweat to make medicine, then is aided with Sweet Almond Oil or SIMMONDSIA CHINENSIS SEED OIL or grape seed oil or wheat-germ oil
Based on oily compound essential oil composition.It is brought down a fever by the compound essential oil composition for cold, fever that said components are prepared
Significant effect, fragrant odour make simply, easy to use, without any toxicity and side effects compared to chemical drug, green and healthy, avoid simultaneously
The side effect of oral medication, percutaneous absorption biological availability greatly improve, and the existing anti-secondary work of cold and abating fever Western medicine poison has been effectively relieved
With problem that is big, of high cost, being also easy to produce drug resistance and take inconvenience.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to
So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into
Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of compound essential oil composition for cold, fever, which is characterized in that it counts in parts by weight, it is described for hair of catching a cold
The compound essential oil composition of heat is mainly made of the following raw material：3~25 parts of radix bupleuri essential oil, 2~15 parts of windproof essential oil, Rhizoma Et Radix Notopterygii essential oil
1~10 part of 1~10 part, 2~15 parts of Peppermint essential oil, 1~10 part of schizonepeta essential oil, 2~15 parts of Lavender and chamomile essential oil.
2. the compound essential oil composition according to claim 1 for cold, fever, which is characterized in that in parts by weight
Meter, the compound essential oil composition for cold, fever are mainly made of the following raw material：8~20 parts of radix bupleuri essential oil, windproof essence
4~14 parts of oil, 2~8 parts of Rhizoma Et Radix Notopterygii essential oil, 4~14 parts of Peppermint essential oil, 2~8 parts of schizonepeta essential oil, 4~14 parts of Lavender and ocean
2~8 parts of camomile essential oil.
3. the compound essential oil composition according to claim 1 for cold, fever, which is characterized in that in parts by weight
Meter, the compound essential oil composition for cold, fever are mainly made of the following raw material：12~18 parts of radix bupleuri essential oil, windproof essence
8~12 parts of oil, 4~6 parts of Rhizoma Et Radix Notopterygii essential oil, 8~12 parts of Peppermint essential oil, 4~6 parts of schizonepeta essential oil, 8~12 parts of Lavender and ocean
4~6 parts of camomile essential oil；
Preferably, it counts in parts by weight, the compound essential oil composition for cold, fever is mainly made of the following raw material：Bavin
15 parts of Hu essential oil, 10 parts of windproof essential oil, 5 parts of Rhizoma Et Radix Notopterygii essential oil, 10 parts of Peppermint essential oil, 5 parts of schizonepeta essential oil, 10 parts of Lavender and
5 parts of chamomile essential oil.
4. being used for the compound essential oil composition of cold, fever according to claims 1 to 3 any one of them, which is characterized in that institute
Radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii essential oil, Peppermint essential oil, schizonepeta essential oil, Lavender and chamomile essential oil are stated by natural
Purpose plant extract is made；
Preferably, the extracting method is carbon dioxide supercritical extraction method, steam distillation or physical squeezing extraction method.
What 5. a kind of compound essential oil composition being used for cold, fever according to claims 1 to 3 any one of them was prepared
Preparation.
6. preparation according to claim 5, which is characterized in that the dosage form of the preparation is finish, patch, suppository, paste
Or any one in gelling agent.
7. a kind of preparation method according to the preparation of claim 5 or 6, which is characterized in that the preparation method includes that will weigh
Profit requires 1~3 any one of them to be processed into for the compound essential oil composition of cold, fever and pharmaceutically acceptable auxiliary material
For preparation.
8. the preparation method of preparation according to claim 7, which is characterized in that the preparation method of the finish includes following step
Suddenly：
Successively by radix bupleuri essential oil, windproof essential oil, Rhizoma Et Radix Notopterygii essential oil, Peppermint essential oil, schizonepeta essential oil, Lavender and chamomile essential oil
It is added among base plants oil, is then sufficiently stirred mixing, finish preparation is made；
Preferably, the weight ratio of the compound essential oil composition for cold, fever and base plants oil is 1：6~10；
It is furthermore preferred that the base plants oil is one kind in Sweet Almond Oil, grape seed oil, SIMMONDSIA CHINENSIS SEED OIL, wheat-germ oil.
9. the preparation method of preparation according to claim 7, which is characterized in that the preparation method of the patch includes following step
Suddenly：
By for the compound essential oil composition of cold, fever with thickening matrix with 1：1~2 volume ratio mixing, subsequent heating stirring
20~30min obtains the semisolid fluid of sticky shape, and semisolid fluid is coated on aluminium foil backing with the thickness of 0.3~0.8mm
On layer, it is placed at room temperature for 10~15min solidifications and volatilizes, then cover eva film and adhesion layer and seal, obtain patch preparation；
Preferably, the thickening matrix is one kind in carbomer, HPMC, PVA, PEG, hexadecanol or propylene glycol.
10. a kind of compound essential oil composition or claim being used for cold, fever according to Claims 1 to 4 any one of them
Application of the preparation in improving cold, fever symptom described in 5 or 6.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110302139A (en) * | 2019-07-29 | 2019-10-08 | 河南官渡生物工程有限公司 | A kind of Neopap and preparation method thereof |
| CN111150829A (en) * | 2020-03-11 | 2020-05-15 | 柳州市中医医院 | Essential oil for relieving exterior syndrome and eliminating dampness |
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| CN101112417A (en) * | 2007-07-26 | 2008-01-30 | 山东轻工业学院 | Rheum defervescence liniment and method for preparing the same |
| CN105663360A (en) * | 2016-02-29 | 2016-06-15 | 芜湖禧来旺农业有限公司 | Traditional Chinese medicine composition for treating wind-cold type common cold |
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- 2018-08-10 CN CN201810913271.4A patent/CN108635407A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112417A (en) * | 2007-07-26 | 2008-01-30 | 山东轻工业学院 | Rheum defervescence liniment and method for preparing the same |
| CN105663360A (en) * | 2016-02-29 | 2016-06-15 | 芜湖禧来旺农业有限公司 | Traditional Chinese medicine composition for treating wind-cold type common cold |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110302139A (en) * | 2019-07-29 | 2019-10-08 | 河南官渡生物工程有限公司 | A kind of Neopap and preparation method thereof |
| CN110302139B (en) * | 2019-07-29 | 2022-12-09 | 河南官渡生物工程有限公司 | Acetaminophen suppository and preparation method thereof |
| CN111150829A (en) * | 2020-03-11 | 2020-05-15 | 柳州市中医医院 | Essential oil for relieving exterior syndrome and eliminating dampness |
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