CN108619287A

CN108619287A - Treat Chinese medicine composition, the pill and preparation method thereof of caput femoris necrosis liver void muscle impotence card

Info

Publication number: CN108619287A
Application number: CN201810947832.2A
Authority: CN
Inventors: 曹玉举; 张大鹏; 郭永昌; 胡建庚; 宋京博; 张洪赞; 孙宝霞
Original assignee: ZHENGZHOU TRADITIONAL CHINESE HOSPITAL OF ORTHOPAWDICS
Current assignee: ZHENGZHOU TRADITIONAL CHINESE HOSPITAL OF ORTHOPAWDICS
Priority date: 2018-08-20
Filing date: 2018-08-20
Publication date: 2018-10-09
Anticipated expiration: 2038-08-20
Also published as: CN108619287B

Abstract

The invention discloses a kind of Chinese medicine compositions for treating caput femoris necrosis liver void muscle impotence card, pill and preparation method thereof, which includes the raw material of following parts by weight：44~60 parts of 129~153 parts of prepared fleece flower root, 129~153 parts of Radix Paeoniae Alba, 63~83 parts of radix paeoniae rubra, 63~83 parts of Radix Angelicae Sinensis, 29~45 parts of China rose, 129~153 parts of Canton love-pea vine, 63~83 parts of dalbergia wood, 44~60 parts of green peel, 63~83 parts of Ramulus Taxilli, 44~60 parts of vinegar tortoise plastron, 44~60 parts of Asian puccoon, 44~60 parts of madder and ramulus mori.The Chinese medicine composition of the present invention is using prepared fleece flower root, Radix Paeoniae Alba as monarch drug in a prescription, using radix paeoniae rubra, Radix Angelicae Sinensis, China rose, Canton love-pea vine, dalbergia wood, green peel as ministerial drug, using Ramulus Taxilli, tortoise plastron, Asian puccoon, madder as adjutant, it is to make medicine with ramulus mori, tonification and purgation in combination, giving consideration to both the incidental and fundamental, have nourish liver blood, relaxing tendons and activating collaterals, strengthen muscles and bones, relieving spasm to stop pain, it is easing joint movement the effect of, for caput femoris necrosis liver void muscle impotence demonstrate,prove it is significant in efficacy.

Description

Treat Chinese medicine composition, pill and its preparation of caput femoris necrosis liver void muscle impotence card Method

Technical field

The present invention relates to Chinese medicine compound prescription technical fields, and caput femoris necrosis liver void muscle impotence card is treated in particular to a kind of Chinese medicine composition, pill and preparation method thereof.

Background technology

Caput femoris necrosis is femoral head venous stasis, arterial blood for impaired or interrupting keeps osteocyte and marrow components part dead Subsequent reparation is died and occurred, bone necrosis are then caused, causes femur header structure to change and collapse, causes hip arthralgia And the disease of dysfunction.Caput femoris necrosis can be divided into traumatic necrosis of bone and atraumatic osteonecrosis, and traumatic necrosis of bone is Refer to Hip Fracture caused by a variety of causes, the main inducing of atraumatic restorative technique is to drink and largely use hormone.Such as Malpractice, 80% or so patient can develop into collapse of femoral head in 1~4 year, and then it is arthritic to develop into serious hipbone Stage, it has to take hip replacement.Caput femoris necrosis is apt to occur in 20~50 years old person between twenty and fifty, average age 36 years old, to trouble Person's life brings inconvenience, seriously endangers between twenty and fifty health.

Currently, the means for the treatment of caput femoris necrosis include operative treatment and Chinese medicine, operative treatment includes that marrow core subtracts Pressure art, vessel bundle implantation art, bone grafting operation, osteotomy, arthroplasty of hip, the treatment of porous tantalum stick, mesenchymal stem cell are controlled Treat etc..But operative treatment is very big to human injury, and curative effect cannot also be affirmed；And operative treatment is there are certain risk, and it is postoperative It is easy recurrence.

Caput femoris necrosis claims the scopes such as " bone erosion ", " atrophic debility of bones ", " heumatism ", " hipbone numbness " in Chinese medicine, based on Chinese medicine Guarantor's hip therapy certain effect is achieved in the treatment of early metaphase atraumatic restorative technique, pass through traditional Chinese medicine protect hip treatment Patient can be made to obtain the hip joint relatively painless, function is normal, to delay or avoid to carry out prosthetic replacement.It is many Scholar carries out differentiation of symptoms and signs for classification of syndrome according to traditional Chinese medical theory to this disease, be such as divided into syndrome of qi stagnation and blood stasis, phlegm-stasis in channels, demonstrate,proved through vessle-Bi symptom-complex resistance, The cards types such as caused by liver and kidney deficiency card, and because card legislation choosing side achieves certain effect.But existing differentiation of symptoms and signs for classification of syndrome is still not perfect, cannot Cover all implant treatments.It is common in clinic to arrive a kind of patient not in the range of above-mentioned differentiation of symptoms and signs for classification of syndrome, do not meet yet The characteristics of stating card type, it is that liver void muscle impotence is demonstrate,proved that it is dialectical, which to show us, according to it, and specific clinical manifestation is：It walks lamely, hip pain, abdomen stock Ditch midpoint pain based on secret anguish, or is shown in shouting pain, and lower limb arrested anxious pain, activity is unfavorable, and dimly red tongue lacks tongue, the thin and delicate case of arteries and veins, We are dialectical to demonstrate,prove for liver void muscle impotence.Therefore, there is presently no controlled for the traditional Chinese medicine for treating caput femoris necrosis liver void muscle impotence card Treatment method.

Invention content

In view of this, it is provided by the invention it is a kind of treat caput femoris necrosis liver void muscle impotence card Chinese medicine composition, pill and Preparation method preferably overcomes the above-mentioned problems of the prior art and defect, the treatment caput femoris necrosis liver void muscle impotence The Chinese medicine composition of card selects natural Chinese traditional medicines raw material, using prepared fleece flower root, Radix Paeoniae Alba as monarch drug in a prescription, with radix paeoniae rubra, Radix Angelicae Sinensis, China rose, Canton love-pea vine, dalbergia wood, green peel are ministerial drug, are to make medicine with ramulus mori, in comprehensive utilization using Ramulus Taxilli, tortoise plastron, Asian puccoon, madder as adjutant It states the Action advantage of each Chinese herb and mutually synergistic effect, tonification and purgation in combination, giving consideration to both the incidental and fundamental is lived with nourishing liver blood, relaxing muscles and tendons Network, strengthen muscles and bones, relieving spasm to stop pain, it is easing joint movement the effect of, for caput femoris necrosis liver void muscle impotence demonstrate,prove significant in efficacy, user Just.

A kind of Chinese medicine composition for treating caput femoris necrosis liver void muscle impotence card, includes the raw material of following parts by weight：How is system 129~153 parts of the tuber of multiflower knotweed, 129~153 parts of Radix Paeoniae Alba, 63~83 parts of radix paeoniae rubra, 63~83 parts of Radix Angelicae Sinensis, 29~45 parts of China rose, Canton love-pea vine 129~153 parts, 63~83 parts of dalbergia wood, 44~60 parts of green peel, 63~83 parts of Ramulus Taxilli, 44~60 parts of vinegar tortoise plastron, Asian puccoon 44~60 44~60 parts of part, 44~60 parts of madder and ramulus mori.

Further, the prepared fleece flower root is 134~148 parts, and the Radix Paeoniae Alba is 134~148 parts.

Further, the radix paeoniae rubra is 67~79 parts, and described when being classified as 67~79 parts, the China rose is 33~41 parts, The Canton love-pea vine is 134~148 parts, and the dalbergia wood is 67~79 parts, and the green peel is 49~55 parts.

Further, the Ramulus Taxilli is 67~79 parts, and the vinegar tortoise plastron is 49~55 parts, and the Asian puccoon is 49~55 Part, the madder is 49~55 parts, and the ramulus mori is 49~55 parts.

Further, the prepared fleece flower root is 141 parts, and the Radix Paeoniae Alba is 141 parts, and the radix paeoniae rubra is 73 parts, the Radix Angelicae Sinensis It it is 73 parts, the China rose is 37 parts, and the Canton love-pea vine is 141 parts, and the dalbergia wood is 73 parts, and the green peel is 52 parts, described Ramulus Taxilli is 73 parts, and the vinegar tortoise plastron is 52 parts, and the Asian puccoon is 52 parts, and the madder is 52 parts, and the ramulus mori is 52 parts.

The present invention also provides a kind of pills for treating caput femoris necrosis liver void muscle impotence card, and the pill includes above-mentioned controls Treat the Chinese medicine composition of caput femoris necrosis liver void muscle impotence card.

Further, 1~3 part of starch and 10~20 parts of honey have been additionally added in every 100 parts of Chinese medicine compositions.

The present invention also provides a kind of preparation methods of pill that treating caput femoris necrosis liver void muscle impotence card：The pill packet Include the Chinese medicine composition of above-mentioned treatment caput femoris necrosis liver void muscle impotence card；The preparation method includes：The raw material is crushed After be uniformly mixed so as to obtain powder.

The preparation method further includes：By 100 parts of powders, 1~3 part of starch, 10~20 parts of honey and 28~40 Wet ball is made after being mixed in part pure water.

The present invention also provides drying the wet ball to moisture 5wt% or less to obtain vegetable pill, and the vegetable pill is used Active charcoal bag charcoal clothing and with talcum powder polishing, wherein every 100 parts of vegetable pills use 0.45~0.55 part of activated carbon and 0.45 ~0.55 part of talcum powder.

Compared with prior art, a kind of Chinese medicine composition for treating caput femoris necrosis liver void muscle impotence card of the invention, pill And preparation method thereof advantageous effect be：

The Chinese medicine composition of the treatment caput femoris necrosis liver void muscle impotence card of the present invention selects natural Chinese traditional medicines raw material, with system The fleece-flower root, Radix Paeoniae Alba are monarch drug in a prescription, using radix paeoniae rubra, Radix Angelicae Sinensis, China rose, Canton love-pea vine, dalbergia wood, green peel as ministerial drug, with Ramulus Taxilli, tortoise plastron, purple Grass, madder are adjutant, are to make medicine with ramulus mori, comprehensively utilize the Action advantage and mutually synergistic effect of above-mentioned each Chinese herb, Tonification and purgation in combination, giving consideration to both the incidental and fundamental, have nourish liver blood, relaxing tendons and activating collaterals, strengthen muscles and bones, relieving spasm to stop pain and it is easing joint movement the effect of, it is right It is significant in efficacy in caput femoris necrosis liver void muscle impotence card, it is easy to use.In addition, the treatment caput femoris necrosis liver void muscle impotence card of the present invention Pill preparation method it is simple, manufacturing cost is low, and safe to use, no pain has no toxic side effect.

To enable the above objects, features and advantages of the present invention to be clearer and more comprehensible, preferred embodiment cited below particularly is made detailed It is described as follows.

Specific implementation mode

To facilitate the understanding of the present invention, it elaborates to technical scheme of the present invention with reference to the mode of embodiment, Many details are elaborated in the following description in order to fully understand the present invention.

But the invention can be embodied in many other ways as described herein, those skilled in the art can be with Similar improvement is done without violating the connotation of the present invention, therefore the present invention is not limited to the specific embodiments disclosed below.

A kind of Chinese medicine composition for treating caput femoris necrosis liver void muscle impotence card, includes the raw material of following parts by weight：

129~153 parts of prepared fleece flower root as 129 parts, 132 parts, 134 parts, 137 parts, 139 parts, 141 parts, 143 parts, 145 parts, 148 parts, 150 parts or 153 parts etc.；

Such as 129 parts of 129~153 parts of parts of Radix Paeoniae Alba, 132 parts, 134 parts, 137 parts, 139 parts, 141 parts, 143 parts, 145 parts, 148 Part, 150 parts or 153 parts etc.；

Such as 63 parts, 65 parts, 67 parts, 69 parts, 71 parts, 73 parts, 76 parts, 79 parts, 81 parts or 83 parts of 63~83 parts of radix paeoniae rubra；

Such as 63 parts, 65 parts, 67 parts, 69 parts, 71 parts, 73 parts, 76 parts, 79 parts, 81 parts or 83 parts of 63~83 parts of Radix Angelicae Sinensis；

Such as 29 parts, 31 parts, 33 parts, 35 parts, 37 parts, 39 parts, 41 parts, 43 parts or 45 parts of 29~45 parts of China rose；

129~153 parts of Canton love-pea vine as 129 parts, 132 parts, 134 parts, 137 parts, 140 parts, 143 parts, 145 parts, 148 parts, 150 Part or 153 parts etc.；

Such as 63 parts, 65 parts, 67 parts, 69 parts, 71 parts, 73 parts, 76 parts, 79 parts, 81 parts or 83 parts of 63~83 parts of dalbergia wood；

Such as 44 parts, 46 parts, 49 parts, 50 parts, 52 parts, 53 parts, 55 parts, 58 parts or 60 parts of 44~60 parts of green peel；

Such as 63 parts, 65 parts, 67 parts, 69 parts, 71 parts, 73 parts, 76 parts, 79 parts, 81 parts or 83 parts of 63~83 parts of Ramulus Taxilli；

Such as 44 parts, 46 parts, 49 parts, 50 parts, 52 parts, 53 parts, 55 parts, 58 parts or 60 parts of 44~60 parts of vinegar tortoise plastron；

Such as 44 parts, 46 parts, 49 parts, 50 parts, 52 parts, 53 parts, 55 parts, 58 parts or 60 parts of 44~60 parts of Asian puccoon；

Such as 44 parts, 46 parts, 49 parts, 50 parts, 52 parts, 53 parts, 55 parts, 58 parts or 60 parts of 44~60 parts of madder；

Such as 44 parts, 46 parts, 49 parts, 50 parts, 52 parts, 53 parts, 55 parts, 58 parts or 60 parts of 44~60 parts of ramulus mori.

It should be noted that prepared fleece flower root, is the Preparation process product of the fleece-flower root, bitter, sweet, puckery, tepor；Return liver, the heart, Kidney channel.The effect of prepared fleece flower root has filling liver kidney, benefiting essence-blood, black beard and hair, strengthening the bones and muscles and changes turbid lipid-loweringing；It is mainly used for the deficiency of blood and withers Under Huang, dizziness and tinnitus, poliosis, soreness and weakness of waist and knees, extremity numbness, uterine bleeding band and hyperlipidemia etc..What pharmaceutical research proves The tuber of multiflower knotweed has the effects that reducing blood lipid, anti arteriosclerosis, platelet aggregation-against；Fleece-flower root water decoction-alcohol sedimentation liquid is thin to mouse bone marrow granulocyte ancestral Intracellular growth has facilitation；RADIX POLYGONI MULTIFLORI PREPARATA, to hemorrhagic deficiency of blood intragastric administration on mice, can make blood rbc number and blood red egg with warm immersion liquid Bai Hanliang increases, and has the function of promoting hematopoiesis function.《The fleece-flower root is recorded》：Long muscle strengthening the essence, benefiting energy, macrobiosis.《Kaibao Bencao》： Beneficial vim and vigour.《Drugization justice》：Beneficial liver holds back blood, enriching yin.Waist and knee weakness is controlled, muscles and bones is ached.《Compendium of Materia Medica》：The fleece-flower root, white person enter Qi leel, red person enter blood system.Kidney master closes Tibetan, liver controlling conveyance and dispersion, this object temperature bitter and puckery flavor, bitter kidney tonifying, and temperature compensation liver can restrain vital essence, institute With energy blood-nourishing benefit liver, controlling nocturnal emission with astringent drugs kidney-nourishing, muscle reinforcing and bone strengthening is tonic medicine, and not cold not dry, work(is on glutinous rehmannia, all medicines of lucid asparagus.Qi and blood Taihe county, then wind void, carbuncle swells, all diseases of scrofula understand (removing).《Herbal justice》：The tuber of multiflower knotweed specially enters liver kidney, tonic Kidney-Yin, and taste is solid Very thick, slightly and bitter, property is then mild, and all the reason with lower burnt envelope Tibetan meets, therefore can fill out strengthening the essence gas, and there are negative and positive to put down secret effect, non- Relatively the moon such as glutinous rehmannia is solidifying comparable.《Jiangxi herbal medicine》：Make ripe filling liver kidney, benefiting essence-blood.

Radix Paeoniae Alba is the dry root of cohosh Chinese herbaceous peony, and bitter, acid are slightly cold；Return liver, the spleen channel.Radix Paeoniae Alba has blood-nourishing tune Through, astringing YIN to stop sweating, the analgesic of soft liver and suppressing liver-YANG and other effects, it is mainly used for blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat, the side of body Bitterly, abdominal pain, four limbs contraction pain and dizziness of having a headache.Pharmaceutical research shows that Radix Paeoniae Alba has apparent analgesic activity, sedation, smooth Flesh spasmolysis, expansion blood vessel increase the effect of organic blood flow volume, platelet aggregation-against, improve anaemia effect.《This warp》：It removes Blood-arthralgia breaks hard product.It does not record》：Clear and coherent blood vessels, in delaying, dispelling malignant blood, expelling extravasated blood.《The southern regions of the Yunnan Province book on Chinese herbal medicine》：Liver qi invasion pain is received, conscience is raised The spleen channel blood relaxes and is relieved pain through sending down abnormally ascending.

Radix paeoniae rubra, is the dry root of ranunculaceae plant Chinese herbaceous peony or river radix paeoniae rubra, and bitter is slightly cold；Return liver warp.Radix paeoniae rubra has heat-clearing Cool blood and removing blood stasis and analgesics and other effects are mainly used for thermal man's ying blood, febrile virulent maculae, hematemesis and epistaxis, red eye, swell pain, liver-depressed hypochondrium pain, warp Close dysmenorrhoea, Disorder lump in the abdomen is suffered from abdominal pain, injury from falling down and carbuncle swells sore etc..Pharmaceutical research shows that radix paeoniae rubra has antithrombus formation, anti-blood small The effects that plate aggregation, reducing blood lipid and anti arteriosclerosis.

Radix Angelicae Sinensis is the dry root of umbelliferae angelica, sweet in flavor, pungent, warm；Return liver, the heart, the spleen channel.Radix Angelicae Sinensis, which has, enriches blood It promoting blood circulation, menstruction regulating and pain relieving and relaxes bowel and other effects；It is mainly used for blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, void Cold abdominal pain, arthralgia pain due to rheumatism, injury from falling down, ulcer sores and dry constipation of intestines.Pharmaceutical research proves that Radix Angelicae Sinensis has reducing blood lipid, resists and move Pulse atherosclerosis inhibits platelet aggregation, promotes the effects that hemoglobin and RBC acceptor garland rate, antalgic and inflammation relieving.《It does not record》：Middle benefit gas Analgesic, except plug in objective blood, mend five Tibetan, myogenic meat.《Japan hanako materia medica》：A wind cutting is controlled, all blood mend all labor, break extravesated blood, support New blood is Ji Zhu Disorder addictions.《Detailed outline》：Headache, all pains of trusted subordinate are controlled, ease constipation stomach muscles and bones skin and blood are enriched blood.《Book on Chinese herbal medicine is just》：Nutrition can be supported Blood, tonifying Qi production of sperm, five viscera settling, strengthen body, beneficial mind, all tangible deficient diseases are omni-benefiting.Dispel pain, relieving rigidity of muscles and joints, control contraction, The cards such as paralysis, dry, puckery.

China rose is the dry flower of rosaceous plant Chinese rose, sweet in flavor, warm；Return liver warp.China rose has blood menstruation regulating and dredges The strongly fragrant effect of liver solution, is mainly used for qi depression to blood stasis, irregular menstruation, dysmenorrhoea, amenorrhoea and distending pain in the chest and hypochondrium.

Canton love-pea vine is the drying complete stool of legume abrus cantoniensis Hance；It is its sweet in flavor, slight bitter, cool；Return liver, stomach.Canton love-pea vine Have effects that removing dampness through diuresis and removing jaundice, clearing heat and detoxicating and dispersing the depressed liver-qi and alleviating pain, is mainly used for not easypro damp and hot yellow subcutaneous ulcer, side of body rib, epigastric distending pain and breast Carbuncle and painful swelling.

Dalbergia wood, is the dry duramen of legume dalbergia wood wingceltis trunk and root, and taste is acrid in flavour and warm in nature；Return liver, the spleen channel.Dalbergia wood has The effect of removing blood stasis and hemostasis and regulating qi-flowing for relieving pain；It is mainly used for haematemesis, bleeding from five sense organs or subcutaneous tissue, traumatic hemorrhage, liver-depressed hypochondrium pain, obstruction of qi in the chest shouting pain, falls and flutter wound Pain and vomiting abdominal pain etc..Pharmaceutical research shows that dalbergia wood has the effects that reducing blood lipid, antalgic and sedative.

Green peel is rutaceae orange and its drying young fruit of variety or the pericarp of immature fruit；Its bitter, It is pungent, warm；Return liver, courage, stomach.Green peel is with the stagnant effect of soothing the liver relieving stagnant Qi and disperse accumulationization；It is mainly used for distending pain in the chest and hypochondrium, hernia pain Bitterly, newborn addiction, acute mastitis, stagnation of QI due to dyspepsia and abdominal distention etc..

Ramulus Taxilli is the drying stem and branch with leaf of Loranthaceae plant Ramulus Taxilli；Its taste bitter, sweet, flat；Return liver and kidney channel.Mulberry is posted It is raw to have effects that wind-damp dispelling, filling liver kidney, strengthening the bones and muscles and tocolysis member；Be mainly used for arthralgia pain due to rheumatism, soreness and weakness of waist and knees, muscles and bones it is powerless, Uterine bleeding is through more, blood leaking in gestation, fetal irritability and has a dizzy spell.

Tortoise plastron is the carapace and plastron of Testudinidae animal tortoise；Its taste is salty, sweet, is slightly cold；Return liver, kidney, the heart channel of Hang-Shaoyin.Tortoise plastron has The effect of nourishing and suppressing Yang, the strong bone of kidney-nourishing, blood-nourishing bushing and solid warp only collapse；It is mainly used for deficiency of Yin hectic fever, hectic fever due to yin night sweat, dizzy mesh Dizzy, endogenous deficient wind, muscles and bones impotence, forgetful and uterine bleeding of having a guilty conscience are through more.

Asian puccoon is the dry root of comfrey lithospermum euchromum Royle or arnebia guttata Bunge；Its is sweet in flavor, salty, trembles with fear；Converge to heart and liver channels.It is purple Grass has the effect of clearing heat and cooling blood, promoting blood circulation and detoxication and promoting eruption ecchymose removing；It is mainly used for blood-heat and toxin exuberance, atropurpureus macula, measles without adequate eruption, sore Ulcer, eczema and scald.

Madder is the dry root and rhizome of madder wort madder；Its bitter is trembled with fear；Return liver warp.Madder has cool blood, dispels The effect of stasis of blood, hemostasis and promoting menstruation；Be mainly used for haematemesis, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, traumatic hemorrhage, stasis blocking Amenorrhea, joint pain and falling flutter it is swollen Bitterly.

Ramulus mori is the dry twig of moraceae plants mulberry；Its mildly bitter flavor is put down；Return liver warp.Ramulus mori has wind-damp dispelling and sharp joint The effect of；It is numb to be mainly used for Bi condition, shoulder arm and joint pain.

Caput femoris necrosis liver void muscle impotence card clinical manifestation be：Limping, hip pain, groin midpoint pain, secret anguish are It is main, or see shouting pain, lower limb arrested anxious pain, activity is unfavorable, and dimly red tongue lacks tongue.

The course of disease with the passing of time, qi and blood consumption wound, blood stored in the liver main reinforcement, then lose in supporting liver-blood deficiency by tendon and vessel, therefore sees below limb aggregation pain, Muscle arteries and veins contraction.The foster then limb activity of liver blood deficiency tendon and vessel mistake is unfavorable, wasting and atrophy of muscle.Liver-blood deficiency, part, which is lost, supports, then pain is indistinct, Pathogen usually intruding into collateral in protracted disease also visible shouting pain.Liver Channel row is in few abdomen, liver-blood deficiency, therefore groin pain.Blood stored in the liver, chong channel are the sea of blood, the two It mutually nourishes, liver governing tendons, chong channel is sea of channels, main infiltrating irrigation trench, bright together in penis with sun, penis main beam bone and sharp organ .Liver-blood deficiency, not only tendon and vessel is lost and is supported, chong channel also virtual loss, and penis organ is unfavorable, therefore lower limb exercise is unfavorable.The dark red few tongue of tongue, Arteries and veins is thin and delicate be liver void muscle impotence as.

The present invention is for caput femoris necrosis liver void muscle impotence card mainly using the nourishing therapies such as liver blood and relaxing tendons and activating collaterals.

In the raw material of the Chinese medicine composition of the treatment caput femoris necrosis liver void muscle impotence card of the present invention, prepared fleece flower root has tonifying liver It the effect of kidney, benefiting essence-blood and strengthening the bones and muscles, can tonifying liver blood and strengthening the bones and muscles；There is Radix Paeoniae Alba blood-nourishing to hold back cloudy and soft liver relieving spasm to stop pain work( Effect, is suitable for muscle arteries and veins contraction especially；This two medicine shares, and is altogether monarch drug in a prescription, the energy of existing nourishing the liver blood and strengthening the bones and muscles, and has the analgesic of Yanggan muscle It is used.

Radix paeoniae rubra has effects that clearing heat and cooling blood and removing blood stasis and analgesics, and can dissipate the strongly fragrant of Liver Channel；There is Radix Angelicae Sinensis blood-nourishing to enrich blood and change The effect of stasis of blood relieves pain；China rose has effects that promoting blood circulation for regulating menstruation and soothing liver-qi stagnation；Canton love-pea vine has clearing heat and promoting diuresis and dispersing the depressed liver-qi and alleviating pain The effect of；Dalbergia wood has effects that removing blood stasis and hemostasis and regulating qi-flowing for relieving pain；Green peel is with the stagnant effect of soothing the liver relieving stagnant Qi and disperse accumulationization.This six Taste medicine is ministerial drug altogether, existing tonifying liver blood, liver depression of relaxing energy, and there is blood-nourishing myospasm relaxing and regulating qi-flowing for relieving pain to be used.

Mulberry, which is posted, has effects that raw filling liver kidney and strengthening the bones and muscles；Tortoise plastron has nourishing and suppressing Yang, the strong bone of kidney-nourishing and blood-nourishing bushing Effect can treat muscles and bones Impotence numbness；Asian puccoon has effects that clearing heat and cooling blood and promoting blood circulation and detoxication；Madder has cool blood, dissolving stasis, hemostasis and leads to Through the effect of, be longer than treatment joint pain and tendon and vessel numbness resistance.The four traditional Chinese medicine shares, and is altogether adjutant, can nourish the moon blood of liver, with Tendon and vessel, and energy cool blood dissipates the stasis of blood are supported, livering the moon is held back.

Ramulus mori has effects that degrading the channel and sharp joint, is longer than treatment extremities joint and aches numbness, draws all medicines and guide drugs to illness station To make medicine.

The present invention comprehensively utilizes the Action advantage of above-mentioned each Chinese herb and mutually acts synergistically, tonification and purgation in combination, sample Take into account, nourish liver blood with it is soothing the liver, hold back liver with using, it is smooth with China rose, the Canton love-pea vine tune of light peaceful sum with the essence and blood of RADIX POLYGONI MULTIFLORI PREPARATA tonifying liver The item of liver reaches and the disadvantage of lossless impariment of the liver the moon, and to hold back the Radix Paeoniae Alba Gu Huganyin of liver, nourishing the liver blood, relax liver depression, protect liver are cloudy.Nourish liver blood and Real chong channel, strengthening the bones and muscles and sharp organ are suitable for lower limb unfavorable, blood nourishing acupuncture-stimulating, the analgesic of soft liver can effectively release pain, the side's of sending use especially Medicine, more with ramulus mori to make, is enabled drug guide drugs to illness station, has and nourish liver blood, relaxing tendons and activating collaterals, strengthen muscles and bones, delay based on Liver Channel drug It is anxious the effect of relieving pain and is easing joint movement, significant in efficacy for caput femoris necrosis liver void muscle impotence card, it is easy to use.

Preferably, the prepared fleece flower root is 134~148 parts, and the Radix Paeoniae Alba is 134~148 parts.

Preferably, the radix paeoniae rubra is 67~79 parts, and described when being classified as 67~79 parts, the China rose is 33~41 parts, institute It is 134~148 parts to state Canton love-pea vine, and the dalbergia wood is 67~79 parts, and the green peel is 49~55 parts.

Preferably, the Ramulus Taxilli is 67~79 parts, and the vinegar tortoise plastron is 49~55 parts, and the Asian puccoon is 49~55 parts, The madder is 49~55 parts, and the ramulus mori is 49~55 parts.

More preferably, the prepared fleece flower root is 141 parts, and the Radix Paeoniae Alba is 141 parts, and the radix paeoniae rubra is 73 parts, described to be classified as 73 parts, the China rose is 37 parts, and the Canton love-pea vine is 141 parts, and the dalbergia wood is 73 parts, and the green peel is 52 parts, the mulberry Parasitism is 73 parts, and the vinegar tortoise plastron is 52 parts, and the Asian puccoon is 52 parts, and the madder is 52 parts, and the ramulus mori is 52 parts.

Preferably, 1~3 part such as 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 has been additionally added in every 100 parts of Chinese medicine compositions Part starch and 10~20 parts such as 10 parts, 12 parts, 15 parts, 18 parts or 20 parts honey.Preferably, every 100 parts of Chinese traditional medicine compositions 2 parts of starch and 15 parts of honey have been additionally added in object.

Preferably, the preparation method includes：By prepared fleece flower root, Radix Paeoniae Alba, radix paeoniae rubra, Radix Angelicae Sinensis, Canton love-pea vine, dalbergia wood, green peel, mulberry Parasitic, vinegar tortoise plastron and ramulus mori are ground into fine powder as after one group of mixing with pulverizer, using China rose, Asian puccoon and madder as one group It is ground into fine powder with pulverizer after mixing, is then uniformly mixed two groups of traditional Chinese medicine fine powders.Can ensure in this way China rose, Asian puccoon and Madder these itself the lighter raw material of weight also can fully be crushed so that finally obtain powder evenly.

The preparation method further includes by 100 parts of powders, 1~3 part of starch, 10~20 parts of honey and 28~40 parts Wet ball is made after being mixed in pure water.

Preferably, the wet ball is dried to moisture 5% (weight) below to obtain vegetable pill, and the vegetable pill is active Charcoal bag charcoal clothing and with talcum powder polishing, wherein every 100 parts of vegetable pills using 0.45~0.55 part as 0.45 part, 0.48 part, Such as 0.45 part, 0.48 part, 0.5 part, 0.52 part or 0.55 of 0.5 part, 0.52 part or 0.55 part activated carbon and 0.45~0.55 part Part talcum powder.

The Chinese medicine composition and its pill of the present invention is safe to use, has no toxic side effect.Because pill makes simple, easy clothes With easy to carry, when preparation can be not added with or less plus auxiliary material, at low cost, be suitable for big production, therefore dosage form is preferably pill.Certainly, Other dosage forms, such as tablet, capsule, granule etc. can be made as needed.

To facilitate the understanding of the present invention, the technical side further illustrated the present invention with reference to embodiment and specific case Case.

Embodiment 1

(1) Chinese medicine material is weighed：129 parts of prepared fleece flower root, 153 parts of Radix Paeoniae Alba, 63 parts of radix paeoniae rubra, 63 parts of Radix Angelicae Sinensis, Canton love-pea vine 129 Part, 83 parts of dalbergia wood, 60 parts of green peel, 63 parts of Ramulus Taxilli, 60 parts of vinegar tortoise plastron and 44 parts of ramulus mori are crushed after mixing with TF300B type twin-stages Machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(2) Chinese medicine material is weighed：60 parts of 29 parts of China rose, 44 parts of Asian puccoon and madder use TF300B type twin-stage powder after mixing Broken machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(3) above-mentioned two groups of traditional Chinese medicine fine powders are placed in the efficient three-dimensional motion mixer of the types of GH~200 (Harbin medication chemistry is set Standby Co., Ltd produces) in be uniformly mixed to get powder.

(4) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 types trough type mixing machine Equipment Science and Technology Ltd. produces) in, 2 parts of starch first are added and 15 parts of honey are stirred 10min, adds 34 parts of pure water and stirs About 20min is mixed, softwood is obtained.

(5) above-mentioned softwood is placed in YUJ-17B type intelligent and high-efficiencies full automatic machine for producing pills (Tianshui city Hua Yuan pharmaceutical equipments section Skill Co., Ltd produces) in tie rod, rub ball with the hands, obtain the wet ball that rounding is uniform, appearance is consistent, a diameter of 4.0~4.3mm.

(6) the wet ball of above-mentioned preparation is placed in HWL15-1 microwave drying sterilization cases (Tianshui city China garden pharmaceutical equipment science and technology Co., Ltd produces) under the conditions of 50 DEG C of hot winds, 80 DEG C of the temperature inside the box, it is 50~60 minutes dry, solid carbon dioxide point is obtained below 5% Vegetable pill.

(7) above-mentioned vegetable pill is placed in the coating pans of TG~1000 (production of Tianshui city Hua Yuan pharmaceutical equipments Science and Technology Ltd.) Middle packet charcoal clothing, talcum powder polishing, every 100 parts of vegetable pills can be added each 0.5 part of activated carbon, talcum powder, obtain pill.

Embodiment 2

(1) Chinese medicine material is weighed：132 parts of prepared fleece flower root, 150 parts of Radix Paeoniae Alba, 65 parts of radix paeoniae rubra, 65 parts of Radix Angelicae Sinensis, Canton love-pea vine 132 Part, 81 parts of dalbergia wood, 58 parts of green peel, 65 parts of Ramulus Taxilli, 58 parts of vinegar tortoise plastron and 46 parts of ramulus mori are crushed after mixing with TF300B type twin-stages Machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(2) Chinese medicine material is weighed：58 parts of 31 parts of China rose, 46 parts of Asian puccoon and madder use TF300B type twin-stage powder after mixing Broken machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(4) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 types trough type mixing machine Equipment Science and Technology Ltd. produces) in, 1 part of starch first is added and 12 parts of honey are stirred 10min, adds 35 parts of pure water and stirs About 20min is mixed, softwood is obtained.

(7) above-mentioned vegetable pill is placed in TG-1000 coating pans (production of Tianshui city Hua Yuan pharmaceutical equipments Science and Technology Ltd.) Middle packet charcoal clothing, talcum powder polishing, every 100 parts of vegetable pills can be added each 0.45 part of activated carbon, talcum powder, obtain pill.

Embodiment 3

(1) Chinese medicine material is weighed：134 parts of prepared fleece flower root, 148 parts of Radix Paeoniae Alba, 67 parts of radix paeoniae rubra, 67 parts of Radix Angelicae Sinensis, Canton love-pea vine 134 Part, 79 parts of dalbergia wood, 55 parts of green peel, 67 parts of Ramulus Taxilli, 55 parts of vinegar tortoise plastron and 49 parts of ramulus mori are crushed after mixing with TF300B type twin-stages Machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(2) Chinese medicine material is weighed：55 parts of 33 parts of China rose, 49 parts of Asian puccoon and madder use TF300B type twin-stage powder after mixing Broken machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(4) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 types trough type mixing machine Equipment Science and Technology Ltd. produces) in, 1.5 parts of starch first are added and 15 parts of honey are stirred 10min, add 35 parts of pure water Stir about 20min, obtains softwood.

(7) above-mentioned vegetable pill is placed in TG-1000 coating pans (production of Tianshui city Hua Yuan pharmaceutical equipments Science and Technology Ltd.) Middle packet charcoal clothing, talcum powder polishing, every 100 parts of vegetable pills can be added each 0.5 part of activated carbon, talcum powder, obtain pill.

Embodiment 4

(1) Chinese medicine material is weighed：137 parts of prepared fleece flower root, 145 parts of Radix Paeoniae Alba, 71 parts of radix paeoniae rubra, 69 parts of Radix Angelicae Sinensis, Canton love-pea vine 137 Part, 76 parts of dalbergia wood, 53 parts of green peel, 69 parts of Ramulus Taxilli, 53 parts of vinegar tortoise plastron and 50 parts of ramulus mori are crushed after mixing with TF300B type twin-stages Machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(2) Chinese medicine material is weighed：53 parts of 35 parts of China rose, 50 parts of Asian puccoon and madder use TF300B type twin-stage powder after mixing Broken machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(4) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 types trough type mixing machine Equipment Science and Technology Ltd. produces) in, 2 parts of starch first are added and 15 parts of honey are stirred 10min, adds 35 parts of pure water and stirs About 20min is mixed, softwood is obtained.

(7) above-mentioned vegetable pill is placed in TG-1000 coating pans (production of Tianshui city Hua Yuan pharmaceutical equipments Science and Technology Ltd.) Middle packet charcoal clothing, talcum powder polishing, every 100 parts of vegetable pills can be added each 0.48 part of activated carbon, talcum powder, obtain pill.

Embodiment 5

(1) Chinese medicine material is weighed：141 parts of prepared fleece flower root, 141 parts of Radix Paeoniae Alba, 73 parts of radix paeoniae rubra, 73 parts of Radix Angelicae Sinensis, Canton love-pea vine 141 Part, 73 parts of dalbergia wood, 52 parts of green peel, 73 parts of Ramulus Taxilli, 52 parts of vinegar tortoise plastron and 52 parts of ramulus mori are crushed after mixing with TF300B type twin-stages Machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(2) Chinese medicine material is weighed：52 parts of 37 parts of China rose, 52 parts of Asian puccoon and madder use TF300B type twin-stage powder after mixing Broken machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(4) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 types trough type mixing machine Equipment Science and Technology Ltd. produces) in, 1.5 parts of starch first are added and 18 parts of honey are stirred 10min, add 38 parts of pure water Stir about 20min, obtains softwood.

(7) above-mentioned vegetable pill is placed in TG-1000 coating pans (production of Tianshui city Hua Yuan pharmaceutical equipments Science and Technology Ltd.) Middle packet charcoal clothing, talcum powder polishing, every 100 parts of vegetable pills can be added each 0.52 part of activated carbon, talcum powder, obtain pill.

Embodiment 6

(1) Chinese medicine material is weighed：143 parts of prepared fleece flower root, 139 parts of Radix Paeoniae Alba, 76 parts of radix paeoniae rubra, 76 parts of Radix Angelicae Sinensis, Canton love-pea vine 139 Part, 71 parts of dalbergia wood, 50 parts of green peel, 76 parts of Ramulus Taxilli, 50 parts of vinegar tortoise plastron and 53 parts of ramulus mori are crushed after mixing with TF300B type twin-stages Machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(2) Chinese medicine material is weighed：50 parts of 39 parts of China rose, 53 parts of Asian puccoon and madder use TF300B type twin-stage powder after mixing Broken machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(4) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 types trough type mixing machine Equipment Science and Technology Ltd. produces) in, 1.5 parts of starch first are added and 12 parts of honey are stirred 10min, add 30 parts of pure water Stir about 20min, obtains softwood.

Embodiment 7

(1) Chinese medicine material is weighed：148 parts of prepared fleece flower root, 134 parts of Radix Paeoniae Alba, 67 parts of radix paeoniae rubra, 67 parts of Radix Angelicae Sinensis, Canton love-pea vine 134 Part, 79 parts of dalbergia wood, 55 parts of green peel, 79 parts of Ramulus Taxilli, 49 parts of vinegar tortoise plastron and 55 parts of ramulus mori are crushed after mixing with TF300B type twin-stages Machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(2) Chinese medicine material is weighed：49 parts of 41 parts of China rose, 55 parts of Asian puccoon and madder use TF300B type twin-stage powder after mixing Broken machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(4) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 types trough type mixing machine Equipment Science and Technology Ltd. produces) in, 3 parts of starch first are added and 20 parts of honey are stirred 10min, adds 30 parts of pure water and stirs About 20min is mixed, softwood is obtained.

(7) above-mentioned vegetable pill is placed in TG-1000 coating pans (production of Tianshui city Hua Yuan pharmaceutical equipments Science and Technology Ltd.) Middle packet charcoal clothing, talcum powder polishing, every 100 parts of vegetable pills can be added each 0.55 part of activated carbon, talcum powder, obtain pill.

Embodiment 8

(1) Chinese medicine material is weighed：150 parts of prepared fleece flower root, 132 parts of Radix Paeoniae Alba, 81 parts of radix paeoniae rubra, 81 parts of Radix Angelicae Sinensis, Canton love-pea vine 132 Part, 65 parts of dalbergia wood, 46 parts of green peel, 81 parts of Ramulus Taxilli, 46 parts of vinegar tortoise plastron and 58 parts of ramulus mori are crushed after mixing with TF300B type twin-stages Machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(2) Chinese medicine material is weighed：46 parts of 43 parts of China rose, 58 parts of Asian puccoon and madder use TF300B type twin-stage powder after mixing Broken machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(4) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 types trough type mixing machine Equipment Science and Technology Ltd. produces) in, 2.5 parts of starch first are added and 18 parts of honey are stirred 10min, add 38 parts of pure water Stir about 20min, obtains softwood.

Embodiment 9

(1) Chinese medicine material is weighed：153 parts of prepared fleece flower root, 129 parts of Radix Paeoniae Alba, 83 parts of radix paeoniae rubra, 83 parts of Radix Angelicae Sinensis, Canton love-pea vine 153 Part, 63 parts of dalbergia wood, 44 parts of green peel, 83 parts of Ramulus Taxilli, 44 parts of vinegar tortoise plastron and 60 parts of ramulus mori are crushed after mixing with TF300B type twin-stages Machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(2) Chinese medicine material is weighed：44 parts of 45 parts of China rose, 60 parts of Asian puccoon and madder use TF300B type twin-stage powder after mixing Broken machine (production of Tianjin Chinese traditional medicine machine factory) is ground into fine powder, spare.

(4) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 types trough type mixing machine Equipment Science and Technology Ltd. produces) in, 1 part of starch first is added and 10 parts of honey are stirred 10min, adds 40 parts of pure water and stirs About 20min is mixed, softwood is obtained.

Comparative example 1

As different from Example 1, the dosage of prepared fleece flower root is 100 parts, and the dosage of Radix Paeoniae Alba is 160 parts, other compositions and Preparation method is same as Example 1.

Comparative example 2

As different from Example 1, the dosage of radix paeoniae rubra is 50 parts, and the dosage of Radix Angelicae Sinensis is 90 parts of other compositions and preparation method It is same as Example 1.

Comparative example 3

As different from Example 1, the dosage of China rose is 20 parts, and the dosage of Asian puccoon is 40 parts, and the dosage of madder is 70 Part, other compositions and preparation method are same as Example 1.

Comparative example 4

As different from Example 1, the dosage of Canton love-pea vine is 120 parts, and the dosage of dalbergia wood is 90 parts, other compositions and preparation Method is same as Example 1.

Comparative example 5

As different from Example 1, the dosage of green peel is 40 parts, and the dosage of Ramulus Taxilli is 90 parts, other compositions and preparation Method is same as Example 1.

Comparative example 6

As different from Example 1, the dosage of vinegar tortoise plastron is 70 parts, and the dosage of ramulus mori is 40 parts, other compositions and preparation Method is same as Example 1.

It is as follows that compliance test result is carried out to the pill of the treatment caput femoris necrosis of the present invention：

By the patient of 450 caput femoris necrosis, the age is 18~65 years old, is randomly divided into 9 groups, originally by above-mentioned application method The Chinese medicine composition of inventive embodiments 1~9 is treated.

The following diagnostic criteria of patient of above-mentioned 450 caput femoris necrosis judges：

With reference to 2015《Caput femoris necrosis clinic diagnosis specification-plum is flourish》Middle caput femoris necrosis diagnostic criteria.

A. have long-term a large amount of excessive drinking histories, using Adrenal Glucocorticoid history, hip trauma history more.

B. symptom is mainly hip arthralgia, and early function is normal or only abduction and interior receipts is slight limited, the experiment of " 4 " word The positive, with progression of the disease hip abduction and anteflexion, interior outward turning can be limited obviously, until hip joint function completely loses.

C.X line pieces：Necrosis region is hardened band wrapping, segmental, meniscus sign, collapse of femoral head but joint space dimension It holds.

d.MRI：Diagnose the goldstandard of caput femoris necrosis.T1WI:Band-like low signal wrapping fatty (middle high RST) or necrosis Bone (middle signal) is caput femoris necrosis typical image.T2W1：Two-wire is levied, and T2W1 presses fat：Femoral head and cervix removes focal zone bone marrow Oedema and the band-like low signals of T1WI.

Case is included in and exclusion criteria：

1. case selection and inclusion criteria

A. subject signs informed consent form；

B. it is diagnosed as the diagnosis of caput femoris necrosis doctor trained in Western medicine, and ARCO locates I, II, III-a phase by stages；

C., the patient of the state of an illness can independently be described；

D. inpatient.

2. case exclusion criteria

A. merge patient, tumour of severe osteoporosis, severe hypertension and serious cardio-cerebrovascular disorder etc. or mental disease Patient；

B. hip joint function obstacle caused by the other reasons such as osteomyelitis, bone tumour, bone tuberculosis；

C. merge unstable joint, non-union bone fractures, arthroncus, after artificial joint replacement, undue pain, joint live It is dynamic to spend the patient to become larger；

D. patient compliance difference or refusal participate in the patient of this research；

E. other clinical trial persons are being participated in；

F. gestation or nursing period obtain female patient.

Curative effect judges：

The research of hip method for estimating curative effect is protected with reference to Harris grade forms, hip VAS scorings, the caput femoris necrosis based on x-ray Deng formulation the standard of curative effect evaluation.Harris scoring symptoms mitigate computational methods：Improvement degree=(before treatment post-treatment)/treatment Before × 100%.VAS scorings improve level calculating method：Improvement degree=and (before treatment-after treatment)/before treating × 100%.

It cures：Symptom and sign disappears substantially, and Harris, VAS score improvement degree in 51%-100%.

Effectively：Symptom and sign is alleviated, and Harris, VAS score improvement degree in 26%-50%.

In vain：Symptom and sign is preceding without improvement with treatment, and Harris, VAS score improvement degree below 25%.

Application method：It is oral, a 9g, 3 times a day；10 days as a treatment course are used continuously in 3 course for the treatment of present invention After drug composition, statistical result such as the following table 1：

Table 1

Group	Total number of persons	It cures	Effectively	In vain	Total effective rate
						Embodiment 1	50	36	7	7	86%
Embodiment 2	50	38	7	5	90%
						Embodiment 3	50	40	6	4	92%
Embodiment 4	50	42	5	3	94%
						Embodiment 5	50	45	4	1	98%
Embodiment 6	50	42	6	2	96%
						Embodiment 7	50	43	4	3	94%
Embodiment 8	50	40	6	4	88%
						Embodiment 9	50	35	8	7	86%

By upper table 1 it is found that after traditional Chinese medicine composition for treating of the present invention, work well, efficient 86% or more, cure rate Up to 70% or more, it can be seen that, the treatment that pill of the invention demonstrate,proves caput femoris necrosis liver void muscle impotence has preferable effect.Separately Outside, in general from cure rate and effective percentage, the therapeutic effect of embodiment 5 is best.

In addition, inventor also utilize pill made of comparative example 1-6 respectively to 8 groups of patients (every group of 8 caput femoris necrosis Patient, age are 18~65 years old) it is treated, it is all very poor (efficient not surpass without therapeutic effect or therapeutic effect It crosses 50%).

Clinical case 1：Bao so-and-so, man, 37 years old, Henan Province Changyuan County force Qiu village people.Patient goes out after fatigue in May, 2017 Existing double hip pains, can mitigate after rest, not give treatment.Pain aggravates afterwards, shows until Zhongning County institute of traditional Chinese medicine looks into MRI：Bilateral femur Head necrosis, does not give treatment.With later our hospital, outpatient service is that tentative diagnosis is hospitalized and is admitted to hospital with " bilateral femoral head necrosis ", be admitted to hospital symptoms include： It walks lamely, double hip pain are squatted down still, and tongue is dark red, few tongue, and arteries and veins is thin and delicate.

Through training inspection：Bilateral inguinal midpoint tenderness is apparent, percussion pain at the greater trochanter of left side, and double lower limb power is III grade left, IV grade of right side, left side Thomas sign is positive, and the full Deng Baozheng in left side is positive, and the experiment of left side " 4 " word is positive, and right side is negative, Ellis Sign is negative, double hip mobilities：30 ° of left side abduction, interior 10 ° of receipts, 120 ° of buckling, 15 ° of inward turning, 20 ° of outward turning, 40 ° of right side abduction are interior 15 ° of receipts, 130 ° of buckling, 20 ° of inward turning, 15 ° of outward turning.

Auxiliary examination：Positive axle position DR (2017.08.21DR~068337) Findings of pelvis：Left femur head morphology is still Can, show that bone density unevenness, bone trabecula are fuzzy in femoral head, it is seen that capsule sample low-density shadow and patch shape increase in density shadow, left hip Joint space is fine；Right side femoral head density owes uniform, and femur head morphology is fine, and hip joint space can.

Tentative diagnosis：Tcm diagnosis：Bone loses liver void muscle impotence card；Doctor trained in Western medicine diagnoses：Bilateral femoral head necrosis (II phases of ARCO).

The pill of the preparation of the embodiment of the present invention 1 is taken, is taken orally, 3 times a day, each 9g.After a week, the double hips of Patients Patients Symptom improves earlier above.The pill of the preparation of the embodiment of the present invention 1 is taken after 2 weeks, patient pain mitigates earlier above, and function improves earlier above, Vital sign is steady, does not tell special discomfort, it is desirable that discharge.Continue to take drug of the present invention after advising it to leave hospital, takes regular exercise, use with caution Hormone, periodic review liver kidney function.Checked after three months, basic without pain, range of motion is preferable, can normal life, liver kidney Function is normal.

Clinical case 2：Ma, female, 71 years old, the Hui ethnic group, Henan Province Taikang County area just outside a city gate Hui ethnic group people from town.Patient was in nothing in 2011 There is right hip pain in obvious cause, and secret anguish can mitigate after rest.Toss about mostly to see a doctor for many years, with " sciatica " Treatment, gives oral pain alleviating class drug and externally applied ointment (specifically unknown), curative effect is not good enough.Piece is taken the photograph in local hospital within 2015 to be diagnosed as " right side caput femoris necrosis ", does not give treatment.It is in November, 2017, to our hospital, outpatient service with " right side caput femoris necrosis " hospitalize into Institute.Be admitted to hospital symptoms include：Walk lamely, right hip pain is squatted down limited with function limitation, and mind is clear, spirit can, receive dormancy can, two is just normal, Tongue is dark red, few tongue, and arteries and veins is thin and delicate.

Training inspection：1 grade of right side groin midpoint tenderness, percussion pain at greater trochanter of femur, the experiment of bilateral " 4 " word：Left side Feminine gender, right side do not finish.Bilateral allis' sign is negative, and bilateral Thomas sign is positive, and the full Deng Baozheng of bilateral is positive, and double hip joint is lived Dynamic degree：Right side：100 ° of buckling, after stretch in 15 ° 20 ° of 25 ° of abduction, 15 ° of inward turning, 20 ° of outward turning, 30 ° of abductions of receipts.Double lower limb muscular strength：Left side IV grade, IV grade of right side, Negative straight-leg raising test, very abdomen negative of lying on the back, neck sign is negative, and bilateral knee jerk is just Often, Achilles jerk is not drawn.

Auxiliary examination：Double hip joint MRI (the courts 2017.11.01 11986) shows：1. right Hip osteoarthritis；2, right Ischemic focus under side femoral head and right side articular surface of acetabulum；3, soft tissue oedema at the attachment of bilateral greater trochanter of femur considers inflammation；4、 The left a small amount of hydrops of hip joint；5, fibroid.

Tentative diagnosis：Tcm diagnosis：Hip numbness disease, liver void muscle impotence card；Doctor trained in Western medicine diagnoses：1, right Hip osteoarthritis；2、 Right side caput femoris necrosis.

Every inspection is improved after being admitted to hospital, in conjunction with patient over sixty-year-old, long-term illness, wasting QI-blood, liver-blood deficiency.Liver master Muscle, liver blood deficiency then support by muscles and bones mistake, and the dark red few tongue of tongue, thready rapid pulse is the card of liver void muscle impotence.According to tcm treatment according to syndrome differentiation, it then follows mark This is with principle is controlled, and is therapy to nourish liver blood, relaxing tendons and activating collaterals, the pill prepared using the embodiment of the present invention 2 is taken orally, daily 3 It is secondary, each 9g.The pill of the preparation of the embodiment of the present invention 2 is taken after 1 week, patient tells to be delayed when right hip pain discomfort is relatively admitted to hospital Solution continues the pill oral medication for giving the preparation of the embodiment of the present invention 2, and adheres to leaning on crutches walking, coordinates appropriate functional training. On November 20th, 2017, the right hip pain of patient was substantially reduced earlier above, and hip joint function improves earlier above, and ordinary circumstance is good, whole Sb.'s illness took a favorable turn, patient requests' discharge, permits its discharge through higher level doctor's approval.Pay attention to after discharge：1, crutches walking is leant on；2, wind sheltering is advised Cold-dampness, untired, anti-wound, appropriate functional training；3, continue pill oral medication prepared by the embodiment of the present invention 2, it is periodically multiple Look into liver function, kidney function.It is checked in the court after three months, for hip substantially without pain, functional activity is good, can meet daily life, liver Renal function is without exception.

Clinical case 3：Mr. Wang, gender man, 31 years old age, national Han nationality, address：Henan Province Kaifeng County.Patient in Occur double hip pains after fatigue in November, 2015 based on aching to alleviate after rest, does not give treatment.It extremely breaks a seal within 2 months 2016 The double hip MRI inspections of county people's hospital's row are diagnosed as " bilateral femoral head necrosis ", and row operative treatment (specifically unknown), pain is not delayed Solution, after do not carry out system diagnosis and treatment.(specifically unknown) treatment of oral drugs more than 1 year is taken in interruption at most clinic, and pain is not alleviated. To ask system diagnosis and treatment, in November, 2017 to move in our hospital.Be admitted to hospital symptoms include：Crutches walking is leant on, walks lamely, squats down limited, double hip pain companions Function limitation, receive dormancy can, two just adjust, and tongue is dark red, few tongue, and arteries and veins is thin and delicate.

Training inspection：It walks lamely, squats down limited, bilateral inguinal area, iliotibial tract, adductor, gluteus medius tenderness, bilateral turn greatly Son is without tenderness and percussion pain, and for bilateral gluteus maximus without tenderness, double lower limb is isometric, and double lower limb muscular strength is III grade, double ankle maximum spacing 86cm, 10cm fleshes Zhou Jing on kneecap：The equal 43cm in left and right, double hip joint mobility：Equal 90 ° of buckling bilateral, equal 0 ° of interior outward turning bilateral, outside Open up equal 20 ° of bilateral, equal 15 ° of interior receipts bilateral." 4 " word experiment bilateral does not finish, and Thomas sign bilateral is positive, and full Deng Baozheng is bis- Side is positive, and allis' sign bilateral is negative.

Auxiliary examination：The positive axle position of pelvis (2017.11.28X-068405) is shown：Bilateral femoral head form becomes flat, inside shows that bone is close Degree is uneven, and bone trabecula is fuzzy, and interior visible capsule sample low-density shadow and patch shape high density shadow, bilateral femoral head and acetabular bone periphery are visible Osteoproliferation shadow, double hip joint gap turn narrow, 1 lamina of sacrum are not combined.Double hip joint CT (2017.11.28, the court) shows：1、 Bilateral femoral head ischemic necrosis 2, double hip joint chamber hydrops 3, double hip joint regression.Double hip joint MRI (2017.11.28, this Institute) show：1, bilateral femoral head ischemic necrosis 2, double hip joint chamber hydrops 3, bilateral femoral head, neck of femur bone marrow edema.

Tentative diagnosis：Tcm diagnosis：Bone loses, liver void muscle impotence card；Doctor trained in Western medicine diagnoses：Bilateral femoral head necrosis (the equal ARCO in left and right IV phase)

Improved after being admitted to hospital it is every check, be middle-aged male in conjunction with patient, long-term habits of smoking and alcohol drinking, the course of disease with the passing of time, wasting QI-blood, Blood stored in the liver, liver governing tendons, liver-blood deficiency then lose in supporting by muscles and bones, sends out and is lost for bone, and tongue is dark red, and arteries and veins is thin and delicate, dialectical category liver void muscle impotence card. According to tcm treatment according to syndrome differentiation, it then follows simultaneous treatment of principal and subordinate symptoms principle, to nourish liver blood, relaxing tendons and activating collaterals is therapy, using the embodiment of the present invention 3 The pill of preparation takes orally, 3 times a day, each 9g.On December 9th, 2017, patient's ordinary circumstance is good, and double hip pain reliefs are double Side iliac region, iliotibial tract, adductor, gluteus medius tenderness mitigate, and double hip joint mobility improves earlier above, and function improves, patient It is required that discharge, permits its discharge through higher level doctor's approval.Pay attention to after discharge：1, crutches walking, appropriate functional training are leant on；2, not labor is advised Tired, anti-wound uses hormone with caution；3, continue to take drug oral treatment of the present invention, periodic review liver function, kidney function.After three months in The court checks, and for hip substantially without pain, functional activity is good, does not influence daily life, and hepatic and renal function is without exception.

Clinical case 4：Liu, female, 29 years old age, national Han nationality, Shandong Province Laiwu City people from Gangcheng District.Patient is in 2016 It is uncomfortable to occur left hip knee pain after year fatigue in November, in duration secret anguish, shouting pain, tired or activity postemphasis mitigates after rest, Without fever night sweat, do not treat.In January, 2017, pain aggravated, and to certain local hospital admission, takes the photograph after piece and is diagnosed as that " femoral head is bad Extremely ", calcium tablet is given, XIANLING GUBAO JIAONANG takes orally and acupuncture and moxibustion therapy, pain are alleviated.October in 2017 4 Zhu Ru our hospital.It is admitted to hospital Symptoms include：Walk lamely, left hip knee pain, activity and tired postemphasis are alleviated after rest, and left limited hip motion, mind is clear, spirit can, Receive dormancy can, tongue is dark red, few tongue, and arteries and veins is thin and delicate.

Training inspection：Left side groin midpoint tenderness is apparent, there is percussion pain at the greater trochanter of left side, left side gluteus medius tenderness, IV grade on the left of bilateral quadriceps strength, V grade of right side, bilateral Negative straight-leg raising test, Thomas sign is positive, full Deng Baozheng The positive, the experiment of left side " 4 " word is positive, and allis' sign is positive, double hip mobilities：Right side：120 ° of buckling, interior 15 ° of receipts, 20 ° of abduction, 15 ° of inward turning, 15 ° of outward turning, left side：100 ° of buckling, interior 10 ° of receipts, 10 ° of abduction, 5 ° of inward turning, 5 ° of outward turning.Neck sign is negative, lies on the back Very abdomen negative, knee jerk, Achilles jerk are normal, and babinski's sign is negative.

Auxiliary examination：Pelvis positive axis bit slice (the courts number 2017.10.04 068691) shows：Left femur head morphology slightly becomes flat, Show that bone density unevenness, bone trabecula are fuzzy in femoral head, it is seen that capsule sample low-density shadow and patch shape increase in density shadow, left femur The visible osteoproliferation shadow of head periphery, left hip joint space narrow；Right hip joint bony structures, density and hip joint space have no bright It is aobvious abnormal.5 left side transverse process hypertrophy of waist forms pseudarthrosis with auricular plane of sacral bone, and visible lumps shape is high in bilateral ilium periphery soft tissue Density shadow.Double hip joint MRI (the courts number 2017.10.04 11150) shows：1. left femoral head ischemic necrosis：2. left side hip closes Save chamber hydrops.

Tentative diagnosis：Tcm diagnosis：Bone loses, liver void muscle impotence card；Doctor trained in Western medicine diagnoses：Left femur head is downright bad (IV phases of ARCO), left Hip osteoarthritis.

Every inspection is improved after being admitted to hospital, is young women in conjunction with patient, and the inadequate natural endowment mistake day after tomorrow is supported, and liver-blood deficiency, liver is hidden Blood main reinforcement, then tendon and vessel marrow loses and supports liver-blood deficiency, the dark red few tongue of tongue, arteries and veins is thin and delicate be all liver void muscle impotence as.According to Chinese medical discrimination It treating, it then follows simultaneous treatment of principal and subordinate symptoms principle, to nourish liver blood, relaxing tendons and activating collaterals is therapy, the pill prepared using the embodiment of the present invention 4, It is oral, 3 times a day, each 9g.On October 17th, 2017, patient's ordinary circumstance is good, and left hip pain mitigates when being relatively admitted to hospital, work( Can improve, receive dormancy can, two just adjust, and the state of an illness integrally improves, patient requests discharge, through higher level doctor approval permit its discharge.After discharge Pay attention to：1, crutches walking, appropriate functional training are leant on；2, untired, anti-wound uses hormone with caution；3, continue to take drug of the present invention Oral medication, periodic review liver function, kidney function.It is checked in the court after three months, hip is substantially painless, and functional activity is good, not shadow Daily life is rung, hepatic and renal function is without exception.

Clinical case 5：Guo so-and-so, man, 64 years old, national Han nationality, people from Zhengzhou City Henan Province.Patient was in fatigue in 04 month in 2017 Occur double hip pains afterwards, activity postemphasis gives until Zhengzhou pain of neck, shoulder, waist and leg hospital diagnosis is " protrasion of the lumbar intervertebral disci " Institute treats, and gives the treatments such as massage, important hot compress, traction, leaves hospital after malaise symptoms change-session.Malaise symptoms after fatigue in May, 2017 Occur again, until Zhengzhou First People Hospital is diagnosed as " protrasion of the lumbar intervertebral disci ", in hospital and give Sofflower injection and by Treatments, the malaise symptoms such as rub are not affected significantly, and are treated then in June, 2017 to the court.Be admitted to hospital symptoms include：It walks lamely, double hip pain, Activity postemphasis cannot be alleviated after rest.Walk and squat down equal difficulty, mind is clear, spirit can, for weight without significant change, tongue is dark Red, tongue, arteries and veins are thin and delicate less.

Training inspection：Bilateral inguinal midpoint tenderness, tenderness at bilateral greater trochanter, lumbosacral region tenderness, percussion pain, hip joint Musculus flexor muscular strength is IV grade left, IV grade right；Double hip mobilities：Left side：30 ° of abduction, interior 25 ° of receipts, 110 ° of buckling, 20 ° of inward turning, outward turning 20 °, right side：25 ° of abduction, interior 20 ° of receipts, 100 ° of buckling, 15 ° of inward turning, 15 ° of outward turning.Bilateral Thomas sign is positive, and bilateral side is stepped on entirely Fort sign is positive, and the experiment of bilateral " 4 " word is positive, and right side is notable, and bilateral allis' sign is positive, and heel string, knee jerk weaken, babinski sign It is negative.Lumbar vertebrae mobility：Anteflexion 70 °, after stretch 15 °, 15 ° of left and right lateral bending.

Auxiliary examination：Double hip positive axis bit slices (the courts 2017.05.19 067203) are shown：Bilateral femoral head form is fine, femur Show that bone density unevenness, bone trabecula are fuzzy in head, it is seen that capsule sample low-density shadow and high density patch shape increase in density shadow, double hips close Internode gap is fine, and 1 hidden ridge of sacrum is split.

Tentative diagnosis：Tcm diagnosis：Bone loses, liver void muscle impotence card；Doctor trained in Western medicine diagnoses：1. bilateral femoral head necrosis (II phases of ARCO) 2. 3. high blood pressure of the protrasion of the lumbar intervertebral disci.

Every inspection is improved after being admitted to hospital, in conjunction with patient age, and is toiled away, and inadequate natural endowment will be lost and supported, and undermine gas the day after tomorrow Blood.Blood stored in the liver main reinforcement, then tendon and vessel marrow loses and supports liver-blood deficiency, the dark red few tongue of tongue, arteries and veins is thin and delicate be all liver void muscle impotence as.In Cure diagnosis and treatment based on an overall analysis of the illness and the patient's condition, it then follows simultaneous treatment of principal and subordinate symptoms principle, to nourish liver blood, relaxing tendons and activating collaterals is therapy, is prepared using the embodiment of the present invention 5 Pill takes orally, 3 times a day, each 9g.On July 11st, 2017, patient's hip pain was substantially reduced compared with when being admitted to hospital, hip joint function Improve earlier above, ordinary circumstance is good, and whole sb.'s illness took a favorable turn, patient requests' discharge, permits its discharge through higher level doctor's approval.After discharge Pay attention to：1, crutches walking, appropriate functional training are leant on；2, untired, anti-wound uses hormone with caution；3, continue to take drug of the present invention Oral medication, periodic review liver function, kidney function.It is checked in the court after three months, for hip without pain, functional activity is good, does not influence Daily life, hepatic and renal function are without exception.

It should be noted that the pill for the treatment of caput femoris necrosis liver void muscle impotence card prepared by the embodiment of the present invention 1~5 is replaced It is changed to the medicine pill of the treatment caput femoris necrosis liver void muscle impotence card of the preparation of the embodiment of the present invention 6~9, can reach above-mentioned same Experiment effect.

The preferred embodiment of the present invention is above are only, is not intended to restrict the invention, for those skilled in the art For member, inventive formulation and preparation process can have various modifications and variations.All within the spirits and principles of the present invention, institute Any modification, equivalent substitution, improvement and etc. of work, should all be included in the protection scope of the present invention.

Claims

1. a kind of Chinese medicine composition for treating caput femoris necrosis liver void muscle impotence card, it is characterised in that：Including following parts by weight Raw material：129~153 parts of prepared fleece flower root, 129~153 parts of Radix Paeoniae Alba, 63~83 parts of radix paeoniae rubra, 63~83 parts of Radix Angelicae Sinensis, China rose 29~45 Part, 129~153 parts of Canton love-pea vine, 63~83 parts of dalbergia wood, 44~60 parts of green peel, 63~83 parts of Ramulus Taxilli, 44~60 parts of vinegar tortoise plastron, 44~60 parts of 44~60 parts of Asian puccoon, 44~60 parts of madder and ramulus mori.

2. the Chinese medicine composition for the treatment of caput femoris necrosis liver void muscle impotence card according to claim 1, it is characterised in that：It is described Prepared fleece flower root is 134~148 parts, and the Radix Paeoniae Alba is 134~148 parts.

3. the Chinese medicine composition for the treatment of caput femoris necrosis liver void muscle impotence card according to claim 1, it is characterised in that：It is described Radix paeoniae rubra is 67~79 parts, and described when being classified as 67~79 parts, the China rose is 33~41 parts, and the Canton love-pea vine is 134~148 Part, the dalbergia wood is 67~79 parts, and the green peel is 49~55 parts.

4. the Chinese medicine composition for the treatment of caput femoris necrosis liver void muscle impotence card according to claim 1, it is characterised in that：It is described Ramulus Taxilli is 67~79 parts, and the vinegar tortoise plastron is 49~55 parts, and the Asian puccoon is 49~55 parts, and the madder is 49~55 parts, The ramulus mori is 49~55 parts.

5. the Chinese medicine composition for the treatment of caput femoris necrosis liver void muscle impotence card according to claim 1, it is characterised in that：It is described Prepared fleece flower root is 141 parts, and the Radix Paeoniae Alba is 141 parts, and the radix paeoniae rubra is 73 parts, and described when being classified as 73 parts, the China rose is 37 Part, the Canton love-pea vine is 141 parts, and the dalbergia wood is 73 parts, and the green peel is 52 parts, and the Ramulus Taxilli is 73 parts, the vinegar tortoise First is 52 parts, and the Asian puccoon is 52 parts, and the madder is 52 parts, and the ramulus mori is 52 parts.

6. a kind of pill for treating caput femoris necrosis liver void muscle impotence card, it is characterised in that：The pill includes Claims 1 to 5 Any one of described in treatment caput femoris necrosis liver void muscle impotence card Chinese medicine composition.

7. the pill for the treatment of caput femoris necrosis liver void muscle impotence card according to claim 6, it is characterised in that：Every 100 parts of institutes It states and has been additionally added 1~3 part of starch and 10~20 parts of honey in Chinese medicine composition.

8. a kind of preparation method of pill that treating caput femoris necrosis liver void muscle impotence card：It is characterized in that：The pill includes power Profit requires the Chinese medicine composition that the treatment caput femoris necrosis liver void muscle impotence described in any one of 1~5 is demonstrate,proved；The preparation method packet It includes：It is uniformly mixed so as to obtain powder after the raw material is crushed.

9. the preparation method of the pill for the treatment of caput femoris necrosis liver void muscle impotence card according to claim 8, it is characterised in that： Further include：It is made after 100 parts of powders, 1~3 part of starch, 10~20 parts of honey and 28~40 parts of pure water are mixed Wet ball.

10. the preparation method of the pill for the treatment of caput femoris necrosis liver void muscle impotence card according to claim 9, feature exist In：The wet ball is dried to moisture 5wt% or less to obtain vegetable pill, and by the vegetable pill active charcoal bag charcoal clothing and uses talcum Powder polishing, wherein every 100 parts of vegetable pills use 0.45~0.55 part of activated carbon and 0.45~0.55 part of talcum powder.