CN108618141A - It is a kind of can strengthen immunity, preserving moisture and protecting skin bird's nest composition and preparation method thereof - Google Patents
It is a kind of can strengthen immunity, preserving moisture and protecting skin bird's nest composition and preparation method thereof Download PDFInfo
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- CN108618141A CN108618141A CN201810190448.2A CN201810190448A CN108618141A CN 108618141 A CN108618141 A CN 108618141A CN 201810190448 A CN201810190448 A CN 201810190448A CN 108618141 A CN108618141 A CN 108618141A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of energy strengthen immunity, the bird's nest compositions and preparation method thereof of preserving moisture and protecting skin, belong to field of health care products.The bird's nest composition of the energy strengthen immunity, preserving moisture and protecting skin, includes the raw material of following parts by weight：5 30 parts of bird's nest, 5 30 parts of matrimony vine, 5 30 parts of jujube.It is safe healthy food material that bird's nest composition provided by the invention is raw materials used, and production technology meets food hygiene related request, and edible safety is without any side effects, can be eaten for a long time, and has the function of that immunity, preserving moisture and protecting skin is remarkably reinforced.
Description
Technical field
The present invention relates to a kind of energy strengthen immunity, the bird's nest compositions and preparation method thereof of preserving moisture and protecting skin, belong to health care
Product field.
Background technology
Hypoimmunity or immunity it is unsound be the pathogenetic underlying causes of many diseases.Human immune system is perfect, then
Bodily harmony, health；Otherwise body damage shows as easy infection or easily sick state." in healthy tendency deposits, heresy can not be done, the institute of heresy
Gather, gas must be empty ", healthy tendency refers to just the disease resistance of human body, that is, immunity, and positive unsaturated vapor shows as the chronic diseases marked by deficiency of vital energy, pays attention to protecting
It is without damage most important to protect immune system.
The crowd of hypoimmunity, is easy to be attacked by the disease, and further affects the health of people, to shadow
Ring daily life, working and learning.Strengthen immunity safeguards health, heavy to closing for present people
It wants.In order to prevent the invasion of disease, under immunity of organism cooperation, therefore, to assure that immune system function normally plays a role,
The mankind could resist the invasion of cause of disease.When there is cause of disease invasion, immune function generates strong " human body self-healing strength " to gulp down
Cause of disease is bitten, the normal balanced capacity of immune system is restored.Also, nowadays people have new concept to the understanding of health and pursuit,
Not sick physiological status is no longer rested on, but the various obstacles that consciousness is brought from various aspects, these obstacles be not good for
Within the scope of health.The product for researching and developing strengthen immunity, can not only enhance fitness, moreover it is possible to improve people’s lives matter
Amount.
Moisturizing, to maintaining the eubolism of Skin Cell and the normal function of skin histology to suffer from important meaning.
Skin keeps itself moisture to be realized by following two approach：First, smegma sebum film and being covered in skin table
Face prevents moisture evaporation；Second is that skin keratin formed cell secrete a kind of water-soluble moisture absorption being called natural moisturizing factor at
Point, help moisture absorption.Currently there are can not piece number moisturizing class cosmetics, the mechanism of action base of these cosmetics
All it is the natural moisture preserving system of simulated skin in sheet, that is, increases the water content of epidermis, promotes the water absorbing capacity of skin,
Mitigate dry skin, furfur situation, skin is helped to restore barrier function, rough skin is made to become soft, smooth.But it is imitated
Fruit is not satisfactory, and too many chemical synthesis ingredient is added, and has certain side effect to skin.
The prior art is less about the correlative study of strengthen immunity, preserving moisture and protecting skin：
102106502 A of CN disclose a kind of health food for having and improving moisture of skin and strengthen immunity function, should
Health food includes following components by weight percentage：Collagen Gly-His-Lys 1.0%-80%；Glucosamine 0.1%-
40%；Aloe extract 0.1%-30.0%；Vitamin C (ascorbic acid) 0.1%-50.0%；Auxiliary material 0.0%-90.0%.It should
Product cannot comprehensively help improve moisture of skin and strengthen immunity, while not account for character and the consumer of raw material
Hobby, mostly chemical synthesis substance or the substance of addition auxiliary chemicals extraction, might have potential side effect.
105030651 A of CN disclose a kind of composition with beautification function and its application, by the group of following parts by weight
Point：100-180 parts of red heart flue fruit powder, 120-180 parts of aloe vera extract, 35-50 parts of haw thorn extract, tea polyphenols
20-50 parts, 30-60 parts of vitamin C, 2-5 parts of Se-enriched yeast.The composition has anti-oxidant, strengthen immunity and improves skin
The effect of moisture.But its processing technology is complicated, and certain chemical industry substance can equally be added, it cannot be guaranteed that the safety of raw material, it can
There can be certain side effect.
In fact no matter in real life, or in beauty practice, people shall not go to talk beauty far from health, just
As in medicine, health be unable to do without sound immunity function, the same beautiful body for be unableing to do without health, be immunized with health, health with
It is beautiful, it will to become the new concept of modern beauty.Therefore a kind of energy strengthen immunity and preserving moisture and protecting skin, and safety comprehensively are developed
Reliable product is present the technical issues of needing to be badly in need of solving.
Invention content
The present invention in order to solve the above-mentioned technical problem, provide it is a kind of can strengthen immunity, preserving moisture and protecting skin bird's nest composition
And preparation method thereof.
The technical solution that the present invention solves above-mentioned technical problem is as follows：It is a kind of can strengthen immunity, preserving moisture and protecting skin bird's nest
Composition includes the raw material of following parts by weight：
5-30 parts of bird's nest, 5-30 parts of matrimony vine, 5-30 parts of jujube.
Product provided by the invention is the composition naturally extracted, and raw materials used is safe healthy food material, food
It is without any side effects with safety, it can be eaten for a long time, and have the function of that immunity, preserving moisture and protecting skin is remarkably reinforced.
There is significant collaboration multiplication between composition each component, by Optimal Experimental and carries out analysis and find：1. Chinese holly
The synergistic effect of Qi jujube compound and bird's nest is apparent, and can greatly improve bird's nest improves the effect of moisture of skin；2. bird's nest with
The combination of matrimony vine jujube can significant strengthen immunity.
Based on the above technical solution, the present invention can also be improved as follows.
Further, the bird's nest composition, includes the raw material of following parts by weight：
15-30 parts of bird's nest, 15-30 parts of matrimony vine, 15-30 parts of jujube.
Further, the bird's nest composition, includes the raw material of following parts by weight：
5 parts of bird's nest, 5 parts of matrimony vine, 5 parts of jujube.
Further, the bird's nest composition, includes the raw material of following parts by weight：
5 parts of bird's nest, 5 parts of matrimony vine, 30 parts of jujube.
Further, the bird's nest composition, includes the raw material of following parts by weight：
30 parts of bird's nest, 30 parts of matrimony vine, 5 parts of jujube.
Further, the bird's nest composition, includes the raw material of following parts by weight：
5 parts of bird's nest, 30 parts of matrimony vine, 30 parts of jujube.
Further, the bird's nest composition, includes the raw material of following parts by weight：
30 parts of bird's nest, 5 parts of matrimony vine, 5 parts of jujube.
Further, the bird's nest composition, includes the raw material of following parts by weight：
15 parts of bird's nest, 30 parts of matrimony vine, 20 parts of jujube.
Further, the bird's nest composition, includes the raw material of following parts by weight：
15 parts of bird's nest, 20 parts of matrimony vine, 30 parts of jujube.
Further, the bird's nest composition, includes the raw material of following parts by weight：
15 parts of bird's nest, 30 parts of matrimony vine, 20 parts of jujube, 15 parts of agar, 45 parts of rock sugar.
Further, the bird's nest composition, includes the raw material of following parts by weight：
15 parts of bird's nest, 20 parts of matrimony vine, 30 parts of jujube, 15 parts of agar, 45 parts of rock sugar.
The present invention also provides it is a kind of it is as described above can strengthen immunity, preserving moisture and protecting skin bird's nest composition preparation side
Method, including：
1. taking bird's nest, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, cleans, and drying must be handled
Bird's nest afterwards, it is spare；
2. matrimony vine and jujube are mixed, water boiling and extraction 1-3 times, water consumption is 5-10 times of matrimony vine and jujube total weight,
Extraction 1-5h every time, filtering, merging filtrate obtain decoction liquor, and the dregs of a decoction discard, and decoction liquor is concentrated into the 35%- of finished weight
40%, concentrate is obtained, it is spare；
3. treated bird's nest and concentrate are mixed, it is added that purified water is quantitative to stir evenly to 259 parts by weight, it is filling,
Up to matrimony vine jujube instant cubilose.
The present invention also provides it is a kind of it is as described above can strengthen immunity, preserving moisture and protecting skin bird's nest composition preparation side
Method, including：
1. taking bird's nest, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, cleans, and drying must be handled
Bird's nest afterwards, it is spare；
2. matrimony vine and jujube are mixed, water boiling and extraction 1-3 times, water consumption is 5-10 times of matrimony vine and jujube total weight,
Extraction 1-5h every time, filtering, merging filtrate obtain decoction liquor, and the dregs of a decoction discard, and decoction liquor is concentrated into the 35%- of finished product total weight
40%, concentrate is obtained, it is spare；
3. agar and rock sugar are mixed, the purified water of 5-8 times of agar and rock sugar total weight is added, is uniformly dissolved, obtains agar
Rock sugar liquid, it is spare；
4. by treated, bird's nest, agar rock sugar liquid and concentrate mix, and add purified water quantitative to 700 parts by weight, stirring
Uniformly, filling to get matrimony vine jujube bird's nest soup with white funguses.
Although it is above-mentioned describe can strengthen immunity, preserving moisture and protecting skin bird's nest composition preparation method, be not limited to
The above method also can pre-process bird's nest, matrimony vine, jujube according to actual demand, pulvis, piece is made in actual production operation
The different product form such as agent and capsule.
The beneficial effects of the invention are as follows：
1. product provided by the invention is the composition naturally extracted, raw materials used is safe healthy food material,
Production technology meets food hygiene related request, therefore this composition edible safety, without any side effects, can be eaten for a long time.
2. it was proved that：Composition provided by the invention has the function of that immunity, preserving moisture and protecting skin is remarkably reinforced.
3. there is significant collaboration multiplication between other the composition each component, by Optimal Experimental and analysis hair is carried out
It is existing：1. the synergistic effect of matrimony vine jujube compound and bird's nest is apparent, can greatly improve bird's nest improves the effect of moisture of skin；②
Bird's nest is combined with matrimony vine jujube can significant strengthen immunity.
4. matrimony vine, jujube and bird's nest are combined together by the present invention, by improving inherent health and external skin water simultaneously
Point, the two complements each other, to achieve the effect that better beautifying face and moistering lotion.
Specific implementation mode
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
Embodiment 1
5 parts by weight bird's nests are weighed, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, cleans, drying,
Treated bird's nest, it is spare；
5 parts by weight matrimony vines and 5 parts by weight jujubes are weighed, are mixed, water boiling and extraction 1 time, water consumption is that matrimony vine and jujube are total
5 times of weight, extract 1h every time, and filtering, merging filtrate obtains decoction liquor, and the dregs of a decoction discard.Above-mentioned decoction liquor is concentrated into finished product weight
The 35%-40% of amount obtains concentrate, spare；
Treated bird's nest and concentrate are mixed, add purified water is quantitative to be stirred evenly to 259 parts by weight, it is filling to get
Matrimony vine jujube instant cubilose.
Embodiment 2
30 parts by weight bird's nests are weighed, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, and cleaning is got rid of
Dry, the bird's nest that obtains that treated is spare；
30 parts by weight matrimony vines and 30 parts by weight jujubes are weighed, are mixed, water boiling and extraction 3 times, water consumption is matrimony vine and jujube
10 times of total weight, extract 5h every time, and filtering, merging filtrate obtains decoction liquor, and the dregs of a decoction discard.Above-mentioned decoction liquor is concentrated into
The 35%-40% of product weight obtains concentrate, spare；
Treated bird's nest and concentrate are mixed, then add purified water is quantitative to be stirred evenly to 259 parts by weight, it is filling, i.e.,
Obtain matrimony vine jujube instant cubilose.
Embodiment 3
5 parts by weight bird's nests are weighed, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, cleans, drying,
Treated bird's nest, it is spare；
5 parts by weight matrimony vines and 30 parts by weight jujubes are weighed, are mixed, water boiling and extraction 1 time, water consumption is that matrimony vine and jujube are total
5 times of weight, extract 5h every time, and filtering, merging filtrate obtains decoction liquor, and the dregs of a decoction discard.Above-mentioned decoction liquor is concentrated into finished product weight
The 35%-40% of amount obtains concentrate, spare；
Treated bird's nest and concentrate are mixed, then add purified water is quantitative to be stirred evenly to 259 parts by weight, it is filling, i.e.,
Obtain matrimony vine jujube instant cubilose.
Embodiment 4
30 parts by weight bird's nests are weighed, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, and cleaning is got rid of
Dry, the bird's nest that obtains that treated is spare；
30 parts by weight matrimony vines and 5 parts by weight jujubes are weighed, are mixed, water boiling and extraction 3 times, water consumption is that matrimony vine and jujube are total
10 times of weight, extract 1h every time, and filtering, merging filtrate obtains decoction liquor, and the dregs of a decoction discard.Above-mentioned decoction liquor is concentrated into finished product
The 35%-40% of weight obtains concentrate, spare；
Treated bird's nest and concentrate are mixed, then add purified water is quantitative to be stirred evenly to 259 parts by weight, it is filling, i.e.,
Obtain matrimony vine jujube instant cubilose.
Embodiment 5
5 parts by weight bird's nests are weighed, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, cleans, drying,
Treated bird's nest, it is spare；
30 parts by weight matrimony vines and 30 parts by weight jujubes are weighed, are mixed, water boiling and extraction 1 time, water consumption is matrimony vine and jujube
10 times of total weight, extract 5h every time, and filtering, merging filtrate obtains decoction liquor, and the dregs of a decoction discard.Above-mentioned decoction liquor is concentrated into
The 35%-40% of product weight obtains concentrate, spare；
Treated bird's nest and concentrate are mixed, then add purified water is quantitative to be stirred evenly to 259 parts by weight, it is filling, i.e.,
Obtain matrimony vine jujube instant cubilose.
Embodiment 6
30 parts by weight bird's nests are weighed, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, and cleaning is got rid of
Dry, the bird's nest that obtains that treated is spare；
5 parts by weight matrimony vines and 5 parts by weight jujubes are weighed, are mixed, water boiling and extraction 3 times, water consumption is that matrimony vine and jujube are total
5 times of weight, extract 1h every time, and filtering, merging filtrate obtains decoction liquor, and the dregs of a decoction discard.Above-mentioned decoction liquor is concentrated into finished product weight
The 35%-40% of amount obtains concentrate, spare；
Bird's nest and concentrate are mixed, then add purified water is quantitative to be stirred evenly to 259 parts by weight, it is filling big to get matrimony vine
Jujube instant cubilose.
Embodiment 7
15 parts by weight bird's nests are weighed, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, and cleaning is got rid of
Dry, the bird's nest that obtains that treated is spare；
15 parts by weight matrimony vines and 15 parts by weight jujubes are weighed, are mixed, water boiling and extraction 2 times, water consumption is matrimony vine and jujube
8 times of total weight, extract 3h every time, and filtering, merging filtrate obtains decoction liquor, and the dregs of a decoction discard.Above-mentioned decoction liquor is concentrated into finished product
The 35%-40% of weight obtains concentrate, spare；
Treated bird's nest and concentrate are mixed, then add purified water is quantitative to be stirred evenly to 259 parts by weight, it is filling, i.e.,
Obtain matrimony vine jujube instant cubilose.
Embodiment 8
15 parts by weight bird's nests are weighed, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, and cleaning is got rid of
Dry, the bird's nest that obtains that treated is spare；
30 parts by weight matrimony vines and 20 parts by weight jujubes are weighed, are mixed, water boiling and extraction 2 times, water consumption is matrimony vine and jujube
8 times of total weight, extract 2h every time, and filtering, merging filtrate obtains decoction liquor, and the dregs of a decoction discard.Above-mentioned decoction liquor is concentrated into finished product
The 35%-40% of weight obtains concentrate, spare；
Treated bird's nest and concentrate are mixed, then add purified water is quantitative to be stirred evenly to 259 parts by weight, it is filling, i.e.,
Obtain matrimony vine jujube instant cubilose.
Embodiment 9
15 parts by weight bird's nests are weighed, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, and cleaning is got rid of
Dry, the bird's nest that obtains that treated is spare；
20 parts by weight matrimony vines and 30 parts by weight jujubes are weighed, are mixed, water boiling and extraction 2 times, water consumption is matrimony vine and jujube
8 times of total weight, extract 3h every time, and filtering, merging filtrate obtains decoction liquor, and the dregs of a decoction discard.Above-mentioned decoction liquor is concentrated into finished product
The 35%-40% of weight obtains concentrate, spare；
Treated bird's nest and concentrate are mixed, then add purified water is quantitative to be stirred evenly to 259 parts by weight, it is filling, i.e.,
Obtain matrimony vine jujube instant cubilose.
Embodiment 10
15 parts by weight bird's nests are weighed, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, and cleaning is got rid of
Dry, the bird's nest that obtains that treated is spare；
30 parts by weight matrimony vines and 20 parts by weight jujubes are weighed, are mixed, water boiling and extraction 2 times, water consumption is matrimony vine and jujube
8 times of total weight, extract 2h every time, and filtering, merging filtrate obtains decoction liquor, and the dregs of a decoction discard, and above-mentioned decoction liquor is concentrated into finished product
The 35%-40% of weight obtains concentrate, spare；
15 parts by weight of agar are weighed, the purified water of 5 times of agar and rock sugar total weight is added in 45 parts by weight of rock sugar, and dissolving is equal
It is even, agar rock sugar liquid is obtained, it is spare.
By treated, bird's nest, concentrate and rock sugar agar solution mix, then add purified water quantitative to 700 parts by weight, stir
It mixes uniformly, it is filling to get matrimony vine jujube bird's nest soup with white funguses.
Embodiment 11
15 parts by weight bird's nests are weighed, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, and cleaning is got rid of
Dry, the bird's nest that obtains that treated is spare；
20 parts by weight matrimony vines and 30 parts by weight jujubes are weighed, are mixed, water boiling and extraction 2 times, water consumption is matrimony vine and jujube
8 times of total weight, extract 3h every time, and filtering, merging filtrate obtains decoction liquor, and spare, the dregs of a decoction discard, and above-mentioned decoction liquor is concentrated
To the 35-40% of finished weight, concentrate is obtained, it is spare；
15 parts by weight of agar are weighed, the purified water of 5 times of agar and rock sugar total weight is added in 45 parts by weight of rock sugar, and dissolving is equal
It is even, agar rock sugar liquid is obtained, it is spare；
By treated, bird's nest, concentrate and rock sugar agar solution mix, then add purified water quantitative to 700 parts by weight, stir
It mixes uniformly, it is filling to get matrimony vine jujube bird's nest soup with white funguses.
Experimental section
One, toxicological experiment：
The product that embodiment 10 is prepared carries out acute oral toxicity test, three genetic toxicity tests (Ames examinations
Test, mice bone marrow micronucleus and mouse inbred strain), rat feed experiment, sample property within 30 days
For liquid, human oral's recommended dose is daily 70g, and because recommended amounts are larger, we are removed partial supplementary material sample and try
It tests, it is 6g/ days to remove partial supplementary material sample dose, and adult's weight is calculated by 60kg, equivalent to remove partial supplementary material sample recommended dose
For 0.1g/kgbw.With reference to《Health food is examined and assessment technique specification》(version in 2003) is carried out acute using conventional mouse
Oral toxicity experiment, Salmonella reversion test, mouse marrow cell micro nuclear test, mouse inbred strain examine product toxicity.
It was found that the maximum tolerated dose (MTD) of product mouse female to Kunming kind, male is more than 15.00g/kgbw, belong to nothing
Malicious grade.Ames experiments, mouse bone marrow polychromatic erythrocytes micronucleus test, mouse sperm deformity experimental result are feminine gender.With
2.50%, sample incorporation feed is fed with rat 30 days by 5.00%, 10.00% ratio, and control group is raised with basal feed.Experiment
Period, animal growth is good, each group dosage group weight, weightening, food utilization, routine blood indexes, blood biochemistry index, dirty
Compared with the control group, there was no significant difference (P ＞ 0.05) for the amount of thinking highly of and internal organs/weight ratio.Gross anatomy and histopathology inspection
It looks into and has no obviously abnormal change related with sample.Illustrate that the sample is fed for 30 days and obvious toxic-side effects are had no to rat.
Two, improve moisture of skin human experimentation：
The product that embodiment 1 to 11 is prepared according to《Health food is examined and assessment technique specification》(version in 2003)
Improve the human experiment experiment (moisture of test forehead glabella skin) of moisture of skin.
This experiment all subjects' age at 30-50 Sui, moisture of skin≤12, exclude gestation or women breast-feeding their children and
There are the patients such as cardiovascular and cerebrovascular, liver, kidney, haematopoietic disorder.210 subjects are randomly divided into 14 groups, every group of 15 people.
Control group takes placebo, 37g/ times, 1 time a day；
One group of positive control takes matrimony vine and jujube mixture (proportioning is matrimony vine 3g, jujube 2g), 5g/ times, 1 time a day；
Two groups of positive control takes bird's nest, 4.29g/ times, 1 time a day；
It tests one group and takes the composition prepared in the embodiment of the present invention 1,37g/ times, (wherein contain bird's nest 1 time a day
0.71g, matrimony vine 0.71g, jujube 0.71g)；
It tests two groups and takes the composition prepared in the embodiment of the present invention 2,37g/ times, (wherein contain bird's nest 1 time a day
4.29g, matrimony vine 4.29g, jujube 4.29g)；
It tests three groups and takes the composition prepared in the embodiment of the present invention 3,37g/ times, (wherein contain bird's nest 1 time a day
0.71g, matrimony vine 0.71g, jujube 4.29g)；
It tests four groups and takes the composition prepared in the embodiment of the present invention 4,37g/ times, (wherein contain bird's nest 1 time a day
4.29g, matrimony vine 4.29g, jujube 0.71g)；
Experiment five group takes the composition prepared in the embodiment of the present invention 5,37g/ times, (wherein contains bird's nest 1 time a day
0.71g, matrimony vine 4.29g, jujube 4.29g)；
It tests six groups and takes the composition prepared in the embodiment of the present invention 6,37g/ times, (wherein contain bird's nest 1 time a day
4.29g, matrimony vine 0.71g, jujube 0.71g)；
It tests seven groups and takes the composition prepared in the embodiment of the present invention 7,37g/ times, (wherein contain bird's nest 1 time a day
2.14g, matrimony vine 2.14g, jujube 2.14g)；
It tests eight groups and takes the composition prepared in the embodiment of the present invention 8,37g/ times, (wherein contain bird's nest 1 time a day
2.14g, matrimony vine 4.29g, jujube 2.86g)；
It tests nine groups and takes the composition prepared in the embodiment of the present invention 9,37g/ times, (wherein contain bird's nest 1 time a day
2.14g, matrimony vine 2.86g, jujube 4.29g)；
It tests ten groups and takes the composition prepared in the embodiment of the present invention 10,70g/ times, (wherein contain bird's nest 1 time a day
1.5g, matrimony vine 3g, jujube 2g)；
It tests 11 groups and takes the composition prepared in the embodiment of the present invention 11,70g/ times, (wherein contain bird's nest 1 time a day
1.5g, matrimony vine 2g, jujube 3g).
It is continuously taken 90 days according to above-mentioned experimental method, subject does not change original life during experiment and diet is practised
It is used, normal diet.
Table 1 tests the variation of the moisture of front and back subject's volume glabella
| Group | Moisture of skin before experiment | Moisture of skin after experiment | Rise percentage % |
| Control group | 8.78±0.44 | 8.86±0.46 | 0.91% |
| One group of positive control | 8.77±0.38 | 8.99±0.3 | 2.51% |
| Two groups of positive control | 8.69±0.38 | 8.96±0.28 | 3.11% |
| Test one group | 8.83±0.42 | 10.89±0.7** | 24.69% |
| Test two groups | 8.94±0.36 | 11.89±0.66** | 24.05% |
| Test three groups | 8.66±0.43 | 10.73±0.86** | 25.75% |
| Test four groups | 8.69±0.43 | 11.4±1.04** | 23.36% |
| Experiment five group | 8.8±0.52 | 11.01±0.79** | 23.86% |
| Test six groups | 8.9±0.41 | 10.49±0.67** | 21.12% |
| Test seven groups | 8.51±0.41 | 11±1** | 26.09% |
| Test eight groups | 8.93±0.34 | 11.86±1.01** | 33.15% |
| Test nine groups | 8.7±0.38 | 11.31±1.11** | 22.30% |
| Test ten groups | 8.77±0.49 | 11.33±1.03** | 29.99% |
| Test 11 groups | 8.69±0.48 | 11.38±0.84** | 20.71% |
Note：Compared with before take, * is p ＜ 0.05, and * * are P ＜ 0.01.
As can be seen from the table, after taking the present composition, the moisture improvement of volume glabella skin is extremely notable, bird's nest
And matrimony vine jujube mixture improves moisture of skin almost without effect, but the reciprocation of matrimony vine jujube compound and bird's nest is aobvious
It writes, can greatly improve bird's nest improves the effect of moisture of skin.Illustrate that bird's nest uses simultaneously with matrimony vine jujube compound, improves skin
The effect of skin moisture doubles.
Three, strengthen immunity functional experiment：
Using ten groups of preparations of embodiment sample composition according to《Health food is examined and assessment technique specification》(2003
Version) it is tested.
1 material and method
1.1 sample：Ten groups of samples of embodiment, character are liquid, and human oral's recommended dose is daily 70g, because of recommended amounts
It is larger, therefore tested after removing partial supplementary material.It is (to be wherein converted into raw material in 6g/ days to remove partial supplementary material sample dose
1.5g containing bird's nest, matrimony vine 3g, jujube 2g), adult's weight is calculated by 60kg, is converted into and is gone the partial supplementary material sample recommended dose to be
0.1g/kg·bw。
1.2 experimental animals and grouping：SPF grades of ICR female mices 200, weight 18-22g, by Hunan Si Laike scapes up in fact
Company of Animals Ltd.'s offer is tested, experimental animal production licence number is SCXK (Hunan) 2014-0011.Every 40 mouse are one big
Group, totally five big groups.It is 1 group immune, carry out carbonic clearance experiment；2 groups immune, the mouse lymphocyte conversion for carrying out ConA inductions is real
It tests, the determination of activity of NK cells；Immune 3 groups, carry out dirty body ratio measurement, half hemolytic value (HC50) measurement and antibody tormation
The measurement of cell number；It is 4 groups immune, carry out delayed allergy experiment；It is 5 groups immune, carry out Turnover of Mouse Peritoneal Macrophages phagocytosis
Chicken red blood cell is tested.Per 40 mouse of group greatly 4 groups, i.e. control group and low, middle and high dose groups are randomly divided by weight, every group
10 mouse.
1.3 experiment condition：For barrier environment, 22 DEG C -24 DEG C of environment temperature during experiment, humidity 54%-60% is tested dynamic
Object is SYXK (Hunan) 2015-0012 using credit number.
1.4 dosage select and sample treatment：According to human oral's recommended amounts, if product removes basic, normal, high dose of partial supplementary material sample
Amount is respectively that 0.50g/kgbw, 1.00g/kgbw, 3.00g/kgbw (are respectively equivalent to 5,10, the 30 of human body recommended amounts
Times).When experiment, take partial supplementary material sample 5.00g, 10.00g, 30.00g that distilled water is added to be settled to 200ml respectively, by 0.2ml/
10gbw volumes are to intragastric administration on mice, once a day, continuous gavage at least 30 days.Control group gavage gives isometric distilled water.
1.5 key instruments and reagent：Animal platform balance, assay balance, clean bench, carbon dioxide incubator, centrifuge,
722S spectrophotometers, constant water bath box, microplate reader, microscope etc..
Sterile surgical instrument, vernier caliper, micro syringe, cell counter, the flat tissue culture plate in 24 holes and 96 holes,
The U-shaped tissue culture plate in 96 holes, glass dish, gauze, test tube, glass frame etc..
SRBC, physiological saline, Hank ' s liquid, RPMH640 culture solutions, calf serum, mycillin, ConA, 1% ice vinegar
Acid, the HCL solution of 1mol/L, acid isopropyl alcohol, MTT, PBS buffer solution (pH7.2-7.4), complement (guinea pig serum), SA buffering
Liquid, agarose, Dou Shi reagents, YAC-1 cells, sodium lactate, nitro tetrazolium chloride, Phenazine Dimethyl Sulfate, oxidized form are auxiliary
Enzyme I, the Tris-HCL buffer solutions of 0.2mol/L, 2.5%Triton, india ink, 0.1% sodium carbonate, chicken red blood cell, first
Alcohol, Giemsa dye liquors etc..
1.6 experimental method：
1.6.1 delayed allergy (DTH)：Mouse peritoneal is injected after SRBC sensitization 4 days, and it is thick to measure left back toes portion
Degree measures left back toes portion thickness for 24 hours then in measuring point injection SRBC (20 μ l/ mouse) after injection.
1.6.2 the mouse lymphocyte transformation experiment of ConA inductions：It is sterile to take spleen, cell suspension is made, microscopy counts,
Culture, the colorimetric estimation on spectrophotometer.
1.6.3 antibody-producting cell detection：Sheep blood, brine 3 times, every mouse is taken to be taken through intraperitoneal injection 2%
Spleen is ground with tweezers, and cell suspension is made, and counts hemolysis plaque number.
1.6.4 the measurement of half hemolytic value：Sheep blood, brine 3 times, every mouse is taken to be taken through intraperitoneal injection 2%
Spleen collects serum, measures OD value.
1.6.5 mouse carbonic clearance test：4 times of india ink is diluted from mouse tail vein injection by weight, with light splitting light
Degree meter measures.
1.6.6 Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell experiment：Mouse peritoneal injects 20% chicken red blood cell, and calculating gulps down
Bite rate and phagocytic index.
1.6.7 NK cell activity：Target cell is subjected to secondary culture for 24 hours before experiment, in microplate reader densitometric value, meter
Calculate NK cell activity.
2 results
2.1 samples influence mouse delayed allergy (DTH)：2 are shown in Table, middle and high dosage group mouse delayed is abnormal
Respond significantly improves (P ＜ 0.05) compared with the control group.
Influence of 2 sample of table to mouse delayed allergy (DTH)
Influence of 2.2 samples to the mouse ConA lymphocyte transfer capabilities induced：3 are shown in Table, each dosage of sample is to mouse
Lymphocyte transformation ability does not make significant difference (P ＞ 0.05).
Influence of 3 sample of table to mouse lymphocyte conversion capability
Influence of 2.3 samples to mouse antibodies cellulation number：4 are shown in Table, middle and high dosage group mouse antibodies cellulation number
It significantly improves compared with the control group (P ＜ 0.05).
Influence of 4 sample of table to mouse antibodies cellulation number
| Grouping | Number of animals (only) | Hemolysis plaque number (a/106A splenocyte) | P values |
| Control group | 10 | 133±50 | |
| Low dosage | 10 | 170±57 | 0.35 |
| Middle dosage | 10 | 209±71 | 0.015 |
| High dose | 10 | 225±48 | 0.003 |
2.4 samples are to mouse half hemolytic value (HC50) influence：5 are shown in Table, middle and high dosage group mouse half hemolytic value
(HC50) significantly improve compared with the control group (P ＜ 0.05).
Influence of 5 sample of table to mouse half hemolytic value
| Grouping | Number of animals (only) | Half hemolytic value | P values |
| Control group | 10 | 156.02±46.37 | |
| Low dosage | 10 | 184.03±53.65 | 0.413 |
| Middle dosage | 10 | 209.16±50.44 | 0.042 |
| High dose | 10 | 215.49±35.83 | 0.021 |
Influence of 2.5 samples to mouse monokaryon-macrophage carbonic clearance：6 are shown in Table, each dosage of sample is to mouse carbonic clearance
Ability does not make significant difference (P ＞ 0.05).
Influence of 6 sample of table to mouse monokaryon-macrophage carbonic clearance
| Grouping | Number of animals (only) | Phagocytic index (a) | P values |
| Control group | 10 | 5.75±0.65 | |
| Low dosage | 10 | 6.01±0.99 | 0.187 |
| Middle dosage | 10 | 6.29±0.77 | |
| High dose | 10 | 6.46±0.51 |
2.6 samples swallow mouse macrophage the influence of chicken red blood cell ability：7,8 are shown in Table, each dosage of sample is to mouse
Macrophage phagocytosis chicken red blood cell ability does not make significant difference (P ＞ 0.05).
7 sample of table swallows mouse macrophage the influence of chicken red blood cell phagocytic rate
8 sample of table swallows mouse macrophage the influence of chicken red blood cell phagocytic index
| Grouping | Number of animals (only) | Phagocytic index | P values |
| Control group | 10 | 0.89±0.25 | |
| Low dosage | 10 | 0.94±0.28 | 0.274 |
| Middle dosage | 10 | 1.05±0.26 | |
| High dose | 10 | 1.10±0.24 |
The influence of mouse NK cell activity in 2.7 samples：It is shown in Table 9, middle and high dosage group NK cells in mice activity and control group
Compare and significantly improves (P ＜ 0.05).
9 sample of table significantly improves NK cells in mice activity compared with the control group
It summarizes：Under this laboratory condition, oral gavage give mouse 0.50g/kgbw, 1.00g/kgbw,
The sample 30 days for going partial supplementary material of 3.00g/kgbw dosage, compared with the control group, 1.00g/kgbw, 3.00g/kgbw
Dosage can significantly improve mouse delayed allergy ability, antibody-producting cell number, half hemolytic value, NK cell activity (P ＜
0.05), each dosage is red to mouse monokaryon-macrophage carbonic clearance ability, lymphocyte transformation ability and macrophage phagocytosis chicken
Cell ability does not make significant difference (P ＞ 0.05).The sample is prompted to have the function of strengthen immunity.
Equally, above-mentioned experiment is also carried out to embodiment 1-9 and embodiment 11, the experimental results showed that, embodiment 1-9, reality
The result for applying example 11 is similar with the effect of above-described embodiment 10, has the effect of strengthen immunity.
In addition, inventor also attempts to be combined using various other common raw materials of immunoassay product to take under study for action
Match, such as：Matrimony vine is replaced using ginseng, is made the cubilose product in embodiment 10, under same experiment condition, though the cubilose product
There is an immune function, but its with obvious effects is weaker than cubilose product of the present invention.
Inventor is sieved by consulting amount of literature data and actual experiment to nearly hundred kinds of traditional Chinese and western medicine correlation function raw materials
After choosing, the composite formula selected：Bird's nest 5-30 parts by weight, matrimony vine 5-30 parts by weight, jujube 5-30 parts by weight, immune function
And improve the combination with obvious effects for being better than other raw materials of moisture of skin.
Especially when formula is：Bird's nest 15-30 parts by weight, matrimony vine 15-30 parts by weight, jujube 15-30 parts by weight improve
The effect of moisture of skin and strengthen immunity is best.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Claims (10)
1. the bird's nest composition of a kind of energy strengthen immunity, preserving moisture and protecting skin, which is characterized in that include the raw material of following parts by weight：
5-30 parts of bird's nest, 5-30 parts of matrimony vine, 5-30 parts of jujube.
2. bird's nest composition according to claim 1, which is characterized in that include the raw material of following parts by weight：
15-30 parts of bird's nest, 15-30 parts of matrimony vine, 15-30 parts of jujube.
3. bird's nest composition according to claim 1, which is characterized in that include the raw material of following parts by weight：
5 parts of bird's nest, 5 parts of matrimony vine, 30 parts of jujube.
4. bird's nest composition according to claim 1, which is characterized in that include the raw material of following parts by weight：
30 parts of bird's nest, 30 parts of matrimony vine, 5 parts of jujube.
5. bird's nest composition according to claim 1, which is characterized in that include the raw material of following parts by weight：
5 parts of bird's nest, 30 parts of matrimony vine, 30 parts of jujube.
6. bird's nest composition according to claim 1, which is characterized in that include the raw material of following parts by weight：
30 parts of bird's nest, 5 parts of matrimony vine, 5 parts of jujube.
7. bird's nest composition according to claim 1, which is characterized in that include the raw material of following parts by weight：
15 parts of bird's nest, 30 parts of matrimony vine, 20 parts of jujube；
Or 15 parts of bird's nest, 20 parts of matrimony vine, 30 parts of jujube；
Or 5 parts of bird's nest, 5 parts of matrimony vine, 5 parts of jujube.
8. bird's nest composition according to claim 1, which is characterized in that include the raw material of following parts by weight：
15 parts of bird's nest, 30 parts of matrimony vine, 20 parts of jujube, 15 parts of agar, 45 parts of rock sugar；
Or 15 parts of bird's nest, 20 parts of matrimony vine, 30 parts of jujube, 15 parts of agar, 45 parts of rock sugar.
9. a kind of such as claim 1-7 any one of them energy strengthen immunity, the preparation side of the bird's nest composition of preserving moisture and protecting skin
Method, which is characterized in that including：
1. taking bird's nest, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, and cleaning dries, and obtains that treated
Bird's nest, it is spare；
2. matrimony vine and jujube are mixed, water boiling and extraction 1-3 times, water consumption is 5-10 times of matrimony vine and jujube total weight, every time
1-5h, filtering are extracted, merging filtrate obtains decoction liquor, and the dregs of a decoction discard, and decoction liquor is concentrated into the 35%-40% of finished weight, is obtained
Concentrate, it is spare；
3. treated bird's nest and concentrate are mixed, be added that purified water is quantitative to stir evenly to 259 parts by weight, it is filling to get
Matrimony vine jujube instant cubilose.
10. a kind of preparation method of the bird's nest composition of energy strengthen immunity as claimed in claim 8, preserving moisture and protecting skin, special
Sign is, including：
1. taking bird's nest, the purified water that 3.5-4.5 times of bird's nest weight is added is soaked, foreign bodies, and cleaning dries, and obtains that treated
Bird's nest, it is spare；
2. matrimony vine and jujube are mixed, water boiling and extraction 1-3 times, water consumption is 5-10 times of matrimony vine and jujube total weight, every time
1-5h, filtering are extracted, merging filtrate obtains decoction liquor, and the dregs of a decoction discard, and decoction liquor is concentrated into the 35%-40% of finished weight, is obtained
Concentrate, it is spare；
3. agar and rock sugar are mixed, the purified water of 5-8 times of agar and rock sugar total weight is added, is uniformly dissolved, obtains agar rock sugar
Liquid, it is spare；
4. by treated, bird's nest, concentrate and agar rock sugar liquid mix, and add purified water is quantitative to be stirred evenly to 700 parts by weight,
It is filling to get matrimony vine jujube bird's nest soup with white funguses.
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| CN111084377A (en) * | 2019-02-20 | 2020-05-01 | 陈喆 | Instant edible bird's nest soup and preparation method thereof |
| CN113367334A (en) * | 2021-06-27 | 2021-09-10 | 中食如宝(珠海)健康科技有限公司 | Instant edible bird's nest for warming kidney and tonifying yang and preparation method thereof |
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