CN108606220A - A kind of anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type and preparation method thereof - Google Patents
A kind of anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type and preparation method thereof Download PDFInfo
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- CN108606220A CN108606220A CN201810238366.0A CN201810238366A CN108606220A CN 108606220 A CN108606220 A CN 108606220A CN 201810238366 A CN201810238366 A CN 201810238366A CN 108606220 A CN108606220 A CN 108606220A
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- exocarpium citri
- citri rubrum
- supernatant
- solid beverage
- medicinal material
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- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 title claims abstract description 76
- 235000013361 beverage Nutrition 0.000 title claims abstract description 53
- 239000007787 solid Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000000463 material Substances 0.000 claims abstract description 35
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 claims abstract description 27
- 241001247821 Ziziphus Species 0.000 claims abstract description 17
- 241000723353 Chrysanthemum Species 0.000 claims abstract description 16
- 235000007516 Chrysanthemum Nutrition 0.000 claims abstract description 16
- 235000019640 taste Nutrition 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 11
- 239000006228 supernatant Substances 0.000 claims description 57
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 23
- 235000019441 ethanol Nutrition 0.000 claims description 16
- 238000006243 chemical reaction Methods 0.000 claims description 15
- 238000002390 rotary evaporation Methods 0.000 claims description 15
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical group O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- RPMNUQRUHXIGHK-PYXJVEIZSA-N apigenin 7-O-neohesperidoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C=C(C=3C=CC(O)=CC=3)OC2=C1 RPMNUQRUHXIGHK-PYXJVEIZSA-N 0.000 claims description 10
- 229930034861 apigenin-7-O-neohesperidoside Natural products 0.000 claims description 10
- 238000005119 centrifugation Methods 0.000 claims description 10
- RPMNUQRUHXIGHK-SBDOOABHSA-N rhoifolin Natural products O([C@@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1Oc1cc(O)c2C(=O)C=C(c3ccc(O)cc3)Oc2c1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1 RPMNUQRUHXIGHK-SBDOOABHSA-N 0.000 claims description 10
- 239000005913 Maltodextrin Substances 0.000 claims description 9
- 229920002774 Maltodextrin Polymers 0.000 claims description 9
- 229940035034 maltodextrin Drugs 0.000 claims description 9
- 238000012545 processing Methods 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 8
- 229930182470 glycoside Natural products 0.000 claims description 8
- 150000002338 glycosides Chemical class 0.000 claims description 8
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 claims description 8
- 235000009815 Momordica Nutrition 0.000 claims description 7
- 241000218984 Momordica Species 0.000 claims description 7
- 229920000858 Cyclodextrin Polymers 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000001116 FEMA 4028 Substances 0.000 claims description 3
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 3
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 3
- 229960004853 betadex Drugs 0.000 claims description 3
- 230000018044 dehydration Effects 0.000 claims description 3
- 238000006297 dehydration reaction Methods 0.000 claims description 3
- 238000004811 liquid chromatography Methods 0.000 claims description 3
- 239000001606 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one Substances 0.000 claims description 2
- 239000002075 main ingredient Substances 0.000 claims description 2
- 229940052490 naringin Drugs 0.000 claims description 2
- 229930019673 naringin Natural products 0.000 claims description 2
- 241001409321 Siraitia grosvenorii Species 0.000 claims 6
- 244000185386 Thladiantha grosvenorii Species 0.000 abstract description 22
- 230000000694 effects Effects 0.000 abstract description 6
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 4
- 229930006000 Sucrose Natural products 0.000 abstract description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract description 3
- 235000009508 confectionery Nutrition 0.000 abstract description 3
- 239000005720 sucrose Substances 0.000 abstract description 3
- 239000008122 artificial sweetener Substances 0.000 abstract 1
- 235000021311 artificial sweeteners Nutrition 0.000 abstract 1
- 230000002633 protecting effect Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 29
- 238000003304 gavage Methods 0.000 description 14
- 241000699666 Mus <mouse, genus> Species 0.000 description 13
- 206010011224 Cough Diseases 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000002245 particle Substances 0.000 description 8
- 239000011780 sodium chloride Substances 0.000 description 8
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 7
- 235000019658 bitter taste Nutrition 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 6
- 244000276331 Citrus maxima Species 0.000 description 5
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 4
- 235000001759 Citrus maxima Nutrition 0.000 description 4
- 238000012449 Kunming mouse Methods 0.000 description 4
- 239000000908 ammonium hydroxide Substances 0.000 description 4
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- 238000002474 experimental method Methods 0.000 description 4
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- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
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- 239000007788 liquid Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- VHLJDTBGULNCGF-UHFFFAOYSA-N Limonin Natural products CC1(C)OC2CC(=O)OCC23C4CCC5(C)C(CC(=O)C6OC56C4(C)C(=O)CC13)c7cocc7 VHLJDTBGULNCGF-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
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- 208000006673 asthma Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
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- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 235000015092 herbal tea Nutrition 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- KBDSLGBFQAGHBE-MSGMIQHVSA-N limonin Chemical compound C=1([C@H]2[C@]3(C)CC[C@H]4[C@@]([C@@]53O[C@@H]5C(=O)O2)(C)C(=O)C[C@@H]2[C@]34COC(=O)C[C@@H]3OC2(C)C)C=COC=1 KBDSLGBFQAGHBE-MSGMIQHVSA-N 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
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- 238000009736 wetting Methods 0.000 description 2
- GHBNZZJYBXQAHG-KUVSNLSMSA-N (2r,3r,4s,5s,6r)-2-[[(2r,3s,4s,5r,6r)-6-[[(3s,8s,9r,10r,11r,13r,14s,17r)-17-[(2r,5r)-5-[(2s,3r,4s,5s,6r)-4,5-dihydroxy-3-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy Chemical group C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@H](CC[C@@H](C)[C@@H]1[C@]2(C[C@@H](O)[C@@]3(C)[C@H]4C(C([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]6[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O6)O)O5)O)CC4)(C)C)=CC[C@H]3[C@]2(C)CC1)C)C(C)(C)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GHBNZZJYBXQAHG-KUVSNLSMSA-N 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 201000008197 Laryngitis Diseases 0.000 description 1
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- 206010036790 Productive cough Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
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- 230000006978 adaptation Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 235000012171 hot beverage Nutrition 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
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- 230000031700 light absorption Effects 0.000 description 1
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- 229930189775 mogroside Natural products 0.000 description 1
- TVJXHJAWHUMLLG-UHFFFAOYSA-N mogroside V Natural products CC(CCC(OC1OC(COC2OC(CO)C(O)C(O)C2OC3OC(CO)C(O)C(O)C3O)C(O)C(O)C1O)C(C)(C)O)C4CCC5(C)C6CC=C7C(CCC(OC8OC(COC9OC(CO)C(O)C(O)C9O)C(O)C(O)C8O)C7(C)C)C6(C)C(O)CC45C TVJXHJAWHUMLLG-UHFFFAOYSA-N 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
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- 231100000614 poison Toxicity 0.000 description 1
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- 238000003672 processing method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses anti-fog haze solid beverages of a kind of Exocarpium Citri Rubrum Sugarless type and preparation method thereof, and solid beverage includes medicinal material composition, and the medicinal material composition includes the medicinal material component of following mass percent：Exocarpium Citri Rubrum 25~35%, Siraitia grosvenorii 35~45%, chrysanthemum 1~5%, jujube 19~35%.The present invention is by being refined and being processed to Exocarpium Citri Rubrum fruit, and it is reasonably matched using Siraitia grosvenorii, chrysanthemum, jujube etc., it can effectively play and drive effect that is bitter and protecting effect, it is added without sucrose and artificial sweetener compared with other Exocarpium Citri Rubrum drinks or formula beverage, taste and sweet mouthfeel smoothes out, and fat and diabetic is suitble to use.
Description
Technical field
The present invention relates to a kind of solid beverages and preparation method thereof, belong to beverage products technical field, refer in particular to one kind
Anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type and preparation method thereof.
Background technology
Contain there are many poisonous and harmful element in haze, intrapulmonary can be inhaled into, and be detained in depths, cause injury of lungs, easily lure
The diseases such as gas producing tube inflammation, laryngitis, asthma and chronic obstructive pulmonary disease.Exocarpium Citri Rubrum is mainly derived from rue as common integration of drinking and medicinal herbs Chinese medicine
The nearly maturation of section's plant Citrus grandis (Citrus grandis ' Tomentosa ') or shaddock (Citrus grandis Osbeck) is dry
Dry exocarp.Its nature and flavor acrid, bitter, warm, primary efficacy are resolving sputum, qi-regulating, control stagnant phlegm in the heart, cough and asthma, vomit eating accumulation,
It is the good medicine that anti-fog haze generates pulmonary disease.Modern pharmacy is the study found that Exocarpium Citri Rubrum main component is aurantiin, Rhoifolin, shaddock
Pi Su, limonin, obakunone etc., but these functional components are also the primary source of Exocarpium Citri Rubrum bitter taste simultaneously.Therefore, how to realize
It drives bitter protect to imitate, is the difficult point and key of Exocarpium Citri Rubrum processing or preparation allotment.
Traditional commercially available Exocarpium Citri Rubrum medicine materical crude slice or preparation go to hide bitter and taste masking by the method for honey refining, sugaring and sweetener mostly,
Pungent, bitter mouthfeel is largely improved, but is not suitable for diabetic use.In addition, during driving bitter, tradition
Salt marsh and alkali washing process, the content of aurantiin can be caused to reduce.Also, traditional Exocarpium Citri Rubrum herbal tea or drink mainly hot drink
Based on, but during becoming cold by heat, due to the conversion of the ingredients such as limonin, generate " rear bitter " effect, also exacerbate drink
Bitter taste.Therefore, how to inhibit the rear conversion of bitter taste and do not reduce the content of aurantiin in medicinal material, be to reduce Exocarpium Citri Rubrum drink bitter taste
Important channel.
Invention content
It is an object of the invention to overcome the problems of the prior art, a kind of anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type is provided
And preparation method thereof, the present invention is closed by the way that Exocarpium Citri Rubrum fruit is refined and processed, and using Siraitia grosvenorii, chrysanthemum, jujube etc.
The proportioning of reason can effectively play the effect driven hardship and protect effect, without sucrose and manually compared with other Exocarpium Citri Rubrum drinks or formula beverage
Sweetener adds, taste and sweet mouthfeel smooth-going, and fat and diabetic is suitble to use.
To achieve the goals above, the present invention is realized according to following technical scheme：
A kind of anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type comprising there is the medicinal material composition, the medicinal material composition to include
The medicinal material component of following mass percent：Exocarpium Citri Rubrum 25~35%, Siraitia grosvenorii 35~45%, chrysanthemum 1~5%, jujube 19~35%.
Further, in the medicinal material composition, Exocarpium Citri Rubrum and Siraitia grosvenorii are main ingredient, and chrysanthemum and jujube are auxiliary.
Further, the medicinal material composition accounts for the mass ratio of fixed beverage no more than 40%.
The preparation method of the above-mentioned anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type comprising have following steps：
S1, the processing of Exocarpium Citri Rubrum medicinal material：Exocarpium Citri Rubrum fruit is taken, crushes after clean dry, is soaked with saturated brine, set in hermetic bag and place
6~8h is poured into reaction kettle, and 6~9 times of 50% ethyl alcohol of volume is added to stir evenly, and adjusts pH value to 7.8~8.5, at 85~95 DEG C
4~6h is reacted, centrifugation point takes supernatant, 55 DEG C of rotary evaporations of supernatant to be concentrated into no alcohol taste, and 0.1~1% β-ring paste is added
Essence stirs evenly, spare；
S2, the processing of other medicinal materials：Siraitia grosvenorii, chrysanthemum and jujube are taken, crushes, sets in reaction kettle after clean dry respectively, add 6
~9 times of volume distilled water stir evenly, and 4h are reacted at 85~95 DEG C, centrifugation point takes supernatant, spare；
S3, supernatant made from supernatant made from S1 steps and S2 steps is merged, 4 DEG C of 6~8h of standing, centrifuging and taking is closed
And rear supernatant, it is spare；
S4, will made from S3 steps merge after 55 DEG C of rotary evaporations of supernatant be concentrated into relative density be 1.05~1.25,
5~25% maltodextrin and 0.1~0.5% CMC-Na is added, it is spare in 5~15min of 20MPa~30MPa homogeneous；
S5, with 145~220 DEG C of inlet temperature, 40~75 DEG C of outlet temperature, 0.5~1.2m of intake3/ min, into material temperature
The parameter of 35~70 DEG C of degree is spray-dried homogeneous object made from above-mentioned S4, extract obtained fine powder, crosses 200 mesh sieve, very
Empty package, the anti-fog haze solid beverage of every bag of 10g, as Exocarpium Citri Rubrum Sugarless type.
Further, the Exocarpium Citri Rubrum active principle is aurantiin and Rhoifolin, and Siraitia grosvenorii active principle is mogroside
V, using high effective liquid chromatography for measuring aurantiin, Rhoifolin and momordica glycoside V content, it is desirable that naringin content >=
6.40%, Rhoifolin content >=4.70%, momordica glycoside V content >=12.50%.
Further, the Siraitia grosvenorii is the Siraitia grosvenorii that vacuum dehydration to water content is 14%~34%.
Compared with prior art, the present invention advantage is：
1, conventional Exocarpium Citri Rubrum is formulated herbal tea or drink, because taste is acute bitter, is not liked by people, and to add sucrose or protein sugar
Deng mode be not suitable for diabetic although mouthfeel can be improved；The formula of the present invention is added Siraitia grosvenorii, jujube etc. and contains
There is the medicinal material of natural sweet taste ingredient, can generate and hide bitter effect and play synergistic effect, adaptation population is more wide
It is general；
2, the bitter taste that can effectively reduce Exocarpium Citri Rubrum to Exocarpium Citri Rubrum powder pre-treating using brine promotes its sugariness, and energy
Further increase the dissolution of the ingredients such as Exocarpium Citri Rubrum active ingredient aurantiin；Further packet is made to Exocarpium Citri Rubrum extract using cyclodextrin
It wraps up in, its bitter taste can be reduced in the case where not reducing active ingredient such as aurantiin, Rhoifolin equal size；
3, the advantages of Siraitia grosvenorii dried using vacuum dehydration, is to improve sweet sense caused by mogroside.
In order to the understanding present invention being more clear, the specific implementation mode of the present invention described in detail below.But it does not answer
It is interpreted as the scope of the present invention and is only limitted to following embodiment, it is all to be accordingly to be regarded as belonging to based on the technology that technical solution of the present invention is realized
The scope of the present invention.
Specific implementation mode
The embodiment of the present invention is provided in the formula of the anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type, includes medicinal material composition, medicine
Material composition includes the medicinal material component of following mass percent：Exocarpium Citri Rubrum 25~35%, Siraitia grosvenorii 30~45%；Chrysanthemum 1~
5%；Jujube 20~35%.
On this basis, it by individually being extracted to Exocarpium Citri Rubrum, and is added into extracting solution after beta-cyclodextrin wrapped up,
It is mixed again with the extracting solution of other medicinal material components, bitter taste can be mitigated to the full extent, the mouthfeel without influencing other flavor components.
The further method that maltodextrin and CMC-Na is added as excipient using spray drying obtains extract fine powder, 200 mesh sieve
Whole grain, vacuum packaging, the as described anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type.
Specific embodiment is as described below：
Embodiment 1
S1, Exocarpium Citri Rubrum fruit 2.5kg is taken, clean, crushed after being dried crosses 8 mesh sieve, is soaked with saturated brine, sets in hermetic bag and place
8h is poured into reaction kettle, and 50% ethyl alcohol that 9 times of medicinal material weight are added stirs evenly, and is adjusted pH value to 8.0, is reacted 4h at 85 DEG C,
3000rpm centrifuges 15min, divides and takes supernatant；55 DEG C of rotary evaporations of supernatant are concentrated into no alcohol taste, and 0.3% β-ring paste is added
Essence stirs evenly, spare；
S2, Siraitia grosvenorii 3.5kg, chrysanthemum 0.5kg and jujube 3.5kg are taken, respectively clean dry, crushed 8 mesh sieve, sets reaction
In kettle, 9 times of volume distilled water is added to stir evenly, 4h is reacted at 95 DEG C, centrifugation point takes supernatant, spare；
S3 is by remaining medicinal material component extract supernatant made from Exocarpium Citri Rubrum extract supernatant made from step S1 and step S2
Liquid merges, 4 DEG C of standing 8h, and supernatant after centrifuging and taking merges is spare；
S4, will made from S3 steps merge after 55 DEG C of rotary evaporations of supernatant be concentrated into relative density be 1.25, be added
15% maltodextrin and 0.25% CMC-Na, it is spare in 22MPa homogeneous 10min；
S5, with 190 DEG C of inlet temperature, 55 DEG C of outlet temperature, intake 0.8m3The parameter pair of/min, 50 DEG C of feeding temperature
Homogeneous object is spray-dried obtained by above-mentioned S4 steps, extract obtained particle, crosses 200 mesh sieves, is vacuum-packed, every bag
The anti-fog haze solid beverage of 10g, as Exocarpium Citri Rubrum Sugarless type.
Embodiment 2
S1, Exocarpium Citri Rubrum fruit 3.0kg is taken, clean, crushed after being dried crosses 8 mesh sieve, is soaked with saturated brine, sets in hermetic bag and place
8h is poured into reaction kettle, and 50% ethyl alcohol that 9 times of medicinal material weight are added stirs evenly, and is adjusted pH value to 8.0, is reacted 4h at 85 DEG C,
3000rpm centrifuges 15min, divides and takes supernatant；55 DEG C of rotary evaporations of supernatant are concentrated into no alcohol taste, and 0.3% β-ring paste is added
Essence stirs evenly, spare；
S2, Siraitia grosvenorii 4.5kg, chrysanthemum 0.2kg and jujube 2.3kg are taken, respectively clean dry, crushed 8 mesh sieve, sets reaction
In kettle, 9 times of volume distilled water is added to stir evenly, 4h is reacted at 95 DEG C, centrifugation point takes supernatant, spare；
S3, by remaining medicinal material component extract supernatant made from Exocarpium Citri Rubrum extract supernatant made from S1 steps and S2 steps
Liquid merges, 4 DEG C of standing 8h, and supernatant after centrifuging and taking merges is spare；
S4, will made from S3 steps merge after 55 DEG C of rotary evaporations of supernatant be concentrated into relative density be 1.25, be added
15% maltodextrin and 0.25% CMC-Na, it is spare in 22MPa homogeneous 10min；
S5, with 170 DEG C of inlet temperature, 55 DEG C of outlet temperature, intake 0.8m3The parameter pair of/min, 50 DEG C of feeding temperature
Homogeneous object is spray-dried obtained by above-mentioned S4 steps, extract obtained particle, crosses 200 mesh sieves, is vacuum-packed, every bag
The anti-fog haze solid beverage of 10g, as Exocarpium Citri Rubrum Sugarless type.
Embodiment 3
S1, Exocarpium Citri Rubrum fruit 2.5kg is taken, 8 mesh sieve is crushed after clean dry, is soaked with saturated brine, is set in hermetic bag and place
8h is poured into reaction kettle, and 50% ethyl alcohol that 6 times of medicinal material weight are added stirs evenly, and is adjusted pH value to 8.0, is reacted 4h at 85 DEG C,
3000rpm centrifuges 15min, divides and takes supernatant；55 DEG C of rotary evaporations of supernatant are concentrated into no alcohol taste, and 0.3% β-ring paste is added
Essence stirs evenly, spare；
S2, Siraitia grosvenorii 3.5kg, chrysanthemum 0.5kg and jujube 3.5kg are taken, respectively clean dry, crushed 8 mesh sieve, sets reaction
In kettle, 6 times of volume distilled water is added to stir evenly, 4h is reacted at 95 DEG C, centrifugation point takes supernatant, spare；
S3, remaining medicinal material component extract supernatant made from Exocarpium Citri Rubrum extract supernatant and S2 steps is made in S1 steps
Merge, 4 DEG C of standing 8h, supernatant after centrifuging and taking merges is spare；
S4, will made from S3 steps merge after 55 DEG C of rotary evaporations of supernatant be concentrated into relative density be 1.25, be added
20% maltodextrin and 0.25% CMC-Na, it is spare in 28MPa homogeneous 15min；
S5, with 215 DEG C of inlet temperature, 70 DEG C of outlet temperature, intake 1.2m3The parameter pair of/min, 60 DEG C of feeding temperature
Homogeneous object is spray-dried obtained by above-mentioned S4 steps, extract obtained particle, crosses 200 mesh sieves, is vacuum-packed, every bag
The anti-fog haze solid beverage of 10g, as Exocarpium Citri Rubrum Sugarless type.
Comparative example 1
S1, Exocarpium Citri Rubrum fruit 4.5kg is taken, clean, crushed after being dried crosses 8 mesh sieve, with saturated brine wetting, sets in hermetic bag and places
8h is poured into reaction kettle, and 50% ethyl alcohol that 9 times of medicinal material weight are added stirs evenly, and is adjusted pH value to 8.0, is reacted 4h at 85 DEG C,
3000rpm centrifuges 15min, divides and takes supernatant；55 DEG C of rotary evaporations of supernatant are concentrated into no alcohol taste, and 0.3% β-ring paste is added
Essence stirs evenly, spare；
S2, chrysanthemum 0.5kg and jujube 4.0kg are taken, cleans respectively, dry, pulverize 8 mesh sieve, sets in reaction kettle, add 9 times
Volume distilled water stirs evenly, and 4h is reacted at 95 DEG C, centrifugation point takes supernatant, spare；
S3, remaining raw extract supernatant described in Exocarpium Citri Rubrum extract supernatant described in S1 steps and S2 steps is merged, 4
DEG C 8h is stood, centrifuging and taking supernatant is spare；
S4,55 DEG C of rotary evaporations of S3 steps supernatant are concentrated into relative density be 1.25,15% maltodextrin is added
With 0.25% CMC-Na, it is spare in 22MPa homogeneous 10min；
S5, with 190 DEG C of inlet temperature, 55 DEG C of outlet temperature, intake 0.8m3The parameter pair of/min, 50 DEG C of feeding temperature
Homogeneous object is spray-dried obtained by above-mentioned S2, extract obtained particle, crosses 200 mesh sieves, is vacuum-packed, every bag of 10g, i.e.,
For the anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type.
Comparative example 2
S1, Exocarpium Citri Rubrum fruit 3.0kg is taken, cleaned, crushed after being dried crosses 8 mesh sieve, the 50% ethyl alcohol stirring of 9 times of medicinal material weight of addition
Uniformly, it adjusts pH value to 8.0,4h is reacted at 85 DEG C, 3000rpm centrifuges 15min, divides and takes supernatant；55 DEG C of rotations of supernatant are steamed
Hair is concentrated into no alcohol taste, spare；
S2, Siraitia grosvenorii 4.5kg, chrysanthemum 0.2kg and jujube 2.3kg are taken, cleans respectively, dry, pulverize 8 mesh sieve, sets anti-
It answers in kettle, 9 times of volume distilled water is added to stir evenly, 4h is reacted at 95 DEG C, centrifugation point takes supernatant, spare；
S3, remaining raw extract supernatant described in Exocarpium Citri Rubrum extract supernatant described in S1 steps and S2 steps is merged, 4
DEG C 8h is stood, centrifuging and taking supernatant is spare；
S4,55 DEG C of rotary evaporations of S3 steps supernatant are concentrated into relative density be 1.25,40% maltodextrin is added
With 0.25% CMC-Na, it is spare in 22MPa homogeneous 10min；
S5, with 170 DEG C of inlet temperature, 55 DEG C of outlet temperature, intake 0.8m3The parameter pair of/min, 50 DEG C of feeding temperature
Homogeneous object is spray-dried obtained by above-mentioned S2, extract obtained particle, crosses 200 mesh sieves, is vacuum-packed, every bag of 10g, i.e.,
For the anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type.
Comparative example 3
S1, Exocarpium Citri Rubrum fruit 3.0kg is taken, clean, crushed after being dried crosses 8 mesh sieve, with saturated brine wetting, sets in hermetic bag and places
8h is poured into reaction kettle, and 50% ethyl alcohol that 9 times of medicinal material weight are added stirs evenly, and is adjusted pH value to 8.0, is reacted 4h at 85 DEG C,
3000rpm centrifuges 15min, divides and takes supernatant；55 DEG C of rotary evaporations of supernatant are concentrated into no alcohol taste, and 0.3% β-ring paste is added
Essence stirs evenly, spare；
S2, Siraitia grosvenorii 3.5kg, chrysanthemum 0.5kg and jujube 3.0kg are taken, cleans respectively, dry, pulverize 8 mesh sieve, sets anti-
It answers in kettle, 9 times of volume distilled water is added to stir evenly, 4h is reacted at 95 DEG C, centrifugation point takes supernatant, spare；
S3, remaining raw extract supernatant described in Exocarpium Citri Rubrum extract supernatant described in S1 steps and S2 steps is merged, 4
DEG C 8h is stood, centrifuging and taking supernatant is spare；
S4,55 DEG C of rotary evaporations of S3 steps supernatant are concentrated into relative density be 1.55, it is standby in 22MPa homogeneous 10min
With；
S5, with 260 DEG C of inlet temperature, 75 DEG C of outlet temperature, intake 1.2m3The parameter pair of/min, 50 DEG C of feeding temperature
Homogeneous object is spray-dried obtained by above-mentioned S2, extract obtained particle, crosses 200 mesh sieves, is vacuum-packed, every bag of 10g, i.e.,
For the anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type.
The contrast verification of embodiment and comparative example
In order to more preferably illustrate the implementation result of the present invention, to the Exocarpium Citri Rubrum Sugarless type of embodiment 1 to 3 and the preparation of comparative example 1 to 3
Anti-fog haze solid beverage sample carries out sensory evaluation, evaluation method is as follows：It takes respectively obtained by above-described embodiment and comparative example
Exocarpium Citri Rubrum Sugarless type 1 bag of 10g of anti-fog haze solid beverage, observes its particle color and luster, the uniformity and hygroscopicity；It sets in transparent glass cup,
It is separately added into boiling water 250ml.It is evaluated respectively from color, taste and dissolubility, the results are shown in Table 1.
The anti-fog haze solid beverage flavor evaluation of 1. Exocarpium Citri Rubrum Sugarless type of table
As shown in Table 1, the hardship that Siraitia grosvenorii can greatly improve in the beverage caused by Exocarpium Citri Rubrum is added to feel, and lacks
Beta-cyclodextrin, which wraps up, and salt oozes processing can promote bitter sense；The solid beverage particle can be improved by being suitably added maltodextrin and CMC-Na
The uniformity and dissolubility, but excessive be added can influence mouthfeel.
The anti-fog haze solid of Exocarpium Citri Rubrum Sugarless type provided for further instruction embodiment of the present invention 1-3 and comparative example 1-3
The content of beverage active principle, the present invention utilize aurantiin, wild paint in high effective liquid chromatography for measuring embodiment and comparative example
The content of glycosides and momordica glycoside V is set, method is as follows：According to Chinese Pharmacopoeia one appended claims of version in 2015, prepare sample and
Aurantiin, Rhoifolin and momordica glycoside V standard items, are measured using high performance liquid chromatography, the results are shown in Table 2.
The anti-fog haze solid beverage active principle content of 2. Exocarpium Citri Rubrum Sugarless type of table
In conjunction with Tables 1 and 2 result it is found that embodiment 2 and comparative example 2 all use identical Exocarpium Citri Rubrum dosage, but embodiment 2
The dissolution of aurantiin in Exocarpium Citri Rubrum, Rhoifolin can be effectively increased by oozing processing using salt, promote the raising of product concentration of active substance.
Play bitter protect of suppression to the anti-fog haze solid beverage of the Exocarpium Citri Rubrum Sugarless type using the processing method of above-described embodiment 1-3 to imitate.
In order to illustrate further the treatment for the anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type that the embodiment of the present invention 1 to 3 is provided
Effect carries out following eliminating phlegm and relieving cough experiment using the mouse of 6 week old：
1, experiment material：Healthy Kunming mouse weight (20.8 ± 2.1) g, by Guangdong medical university Experimental Animal Center
It provides.
2, rearing conditions：Special room sub-cage rearing, the next day replace bedding and padding, freely take the photograph water, ingest (fed standard chow), weekly
It weighs primary.
3, experimental design and grouping：By the KM mouse of health, adaptability raises 3~5d, and it is sensitive to carry out the stimulation of mouse ammonium hydroxide
Property experiment.It is first placed in 500ml glass bell jars, with the ammonium hydroxide 5s of ultrasonic ultrasonic delay line memory spraying 25%, takes out mouse then immediately
By mouse, the interior numbers of coughing of record 2min.By continuous 3d, interior mouse of the cough number more than 10 times of 3min is determined as that stimulation is sensitive
Property qualification mouse, choose 70 mouse and be randomly divided into 7 groups, and be grouped, be administered by the processing mode of table 2.Successive administration 3d,
1 time/d, after 60min is administered, sensitivity testing method is stimulated by aforementioned ammonium hydroxide.When observing and remembering the cough for the first time in mouse 3min
Between (cough latent period) and cough number.
3. experimental animal of table is grouped and dosage
| Group | Dosage | Quantity | Mode of administration |
| Saline control group | 10g/kg | 10 | Gavage gives physiological saline |
| Embodiment 1 | 10g/kg | 10 | Gavage gives the solid beverage prepared by formula of embodiment 1 |
| Embodiment 2 | 10g/kg | 10 | Gavage gives the solid beverage prepared by formula of embodiment 3 |
| Embodiment 3 | 10g/kg | 10 | Gavage gives the solid beverage prepared by formula of embodiment 3 |
| Comparative example 1 | 10g/kg | 10 | Gavage gives the solid beverage prepared by formula of comparative example 1 |
| Comparative example 2 | 10g/kg | 10 | Gavage gives the solid beverage prepared by formula of comparative example 2 |
| Comparative example 3 | 10g/kg | 10 | Gavage gives the solid beverage prepared by formula of comparative example 3 |
4, experimental result：1 to 3 group of embodiment and the incubation period of 1 to 3 group mouse cough number of comparative example and induction cough are equal
Substantially less than saline control group, difference is statistically significant (P ＜ 0.05, P ＜ 0.01), from the knot of embodiment and comparative example
From the point of view of fruit, there are its induction cough latent period of the embodiment and comparative example of Siraitia grosvenorii formula and cough number to be better than no Siraitia grosvenorii and match
The comparative example 2 of side.It is shown in Table 4.
The anti-fog haze solid beverage of 4. Exocarpium Citri Rubrum Sugarless type of table induces ammonium hydroxide the influence of mouse cough number
* the P compared with saline control group is indicated<0.05, * * indicates the P compared with saline control group<0.01
It is that eliminating the phlegm is tested below：
1, experiment material：Healthy Kunming mouse weight (20.5 ± 2.2) g, by Guangdong medical university Experimental Animal Center
It provides.
2, rearing conditions：Special room sub-cage rearing, the next day replace bedding and padding, freely take the photograph water, ingest (fed standard chow), weekly
It weighs primary.
3, experimental design and grouping：Healthy kunming mice 70 is taken, is randomly divided into 7 groups, and carry out by the processing mode of table 4
Grouping, administration.Successive administration 3d, 1 time/d, after last dose 30min, every mouse peritoneal injects 0.25% phenol red solution
0.5mL, after 30min, carbon dioxide smother play puts to death mouse, is rapidly separated escape pipe, the syringe needle polished is inserted
Enter tracheal strips and fixed with surgical thread, injects tracheal strips lavation with 5% NaOH solution 0.5mL, be then gently sucked out, repeat 3
It is secondary, sucking liquid is merged, 3000rpm centrifuges 5min and draws supernatant, and blank is done with 5% NaOH solution, is measured at 546nm
Light absorption value A.Phenol red concentration is calculated using phenol red calibration curve equation, and calculates phenol red secretion increase rate.
5. experimental animal of table is grouped and dosage
| Group | Dosage | Quantity | Mode of administration |
| Saline control group | 10g/kg | 10 | Gavage gives physiological saline |
| Embodiment 1 | 10g/kg | 10 | Gavage gives the solid beverage prepared by formula of embodiment 1 |
| Embodiment 2 | 10g/kg | 10 | Gavage gives the solid beverage prepared by formula of embodiment 3 |
| Embodiment 3 | 10g/kg | 10 | Gavage gives the solid beverage prepared by formula of embodiment 3 |
| Comparative example 1 | 10g/kg | 10 | Gavage gives the solid beverage prepared by formula of comparative example 1 |
| Comparative example 2 | 10g/kg | 10 | Gavage gives the solid beverage prepared by formula of comparative example 2 |
| Comparative example 3 | 10g/kg | 10 | Gavage gives the solid beverage prepared by formula of comparative example 3 |
4, experimental result：Embodiment 1-3 groups increase with the phenol red secretory volume of comparative example 1-3 group airway of mice, and with
Saline control group is statistically significant (P ＜ 0.05, P ＜ 0.01) compared to difference, comes from the result of embodiment and comparative example
See there is the embodiment of the Siraitia grosvenorii formula comparative example higher than no Siraitia grosvenorii formula same as the phenol red secretory volume of comparative example airway of mice
2.It is shown in Table 6.
Influence of the anti-fog haze solid beverage of 6. Exocarpium Citri Rubrum Sugarless type of table to the phenol red excretion of mouse tracheae
* the P compared with saline control group is indicated<0.05, * * indicates the P compared with saline control group<0.01.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than the present invention is protected
The limitation of range is protected, although being explained in detail to the present invention with reference to preferred embodiment, those skilled in the art answer
Work as understanding, technical scheme of the present invention can be modified or replaced equivalently, without departing from the reality of technical solution of the present invention
Matter and range.
Claims (6)
1. a kind of anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type, it is characterised in that include medicinal material composition, the medicinal material composition
It include the medicinal material component of following mass percent：Exocarpium Citri Rubrum 25~35%, Siraitia grosvenorii 35~45%, chrysanthemum 1~5%, jujube 19
~35%.
2. the anti-fog haze solid beverage of a kind of Exocarpium Citri Rubrum Sugarless type according to claim 1, it is characterised in that：The medicinal material composition
In, Exocarpium Citri Rubrum and Siraitia grosvenorii are main ingredient, and chrysanthemum and jujube are auxiliary.
3. a kind of anti-fog haze of Exocarpium Citri Rubrum Sugarless type fixes beverage according to claim 1, it is characterised in that：The medicinal material composition
The mass ratio for accounting for fixed beverage is no more than 40%.
4. the preparation method of the anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type as described in claim 1, it is characterised in that include following
Step：
S1, the processing of Exocarpium Citri Rubrum medicinal material：Take Exocarpium Citri Rubrum fruit, crush after clean dry, soaked with saturated brine, set in hermetic bag place 6~
8h is poured into reaction kettle, and 6~9 times of 50% ethyl alcohol of volume is added to stir evenly, and adjusts pH value to 7.8~8.5, anti-at 85~95 DEG C
4~6h, centrifugation point is answered to take supernatant, 55 DEG C of rotary evaporations of supernatant to be concentrated into no alcohol taste, 0.1~1% beta-cyclodextrin is added
It stirs evenly, it is spare；
S2, the processing of other medicinal materials：Siraitia grosvenorii, chrysanthemum and jujube are taken, crushes, sets in reaction kettle after clean dry respectively, add 6~9
Times volume distilled water stirs evenly, and 4h is reacted at 85~95 DEG C, centrifugation point takes supernatant, spare；
S3, supernatant made from supernatant made from S1 steps and S2 steps is merged, 4 DEG C of 6~8h of standing, after centrifuging and taking merges
Supernatant, it is spare；
S4, will made from S3 steps merge after 55 DEG C of rotary evaporations of supernatant be concentrated into relative density be 1.05~1.25, be added 5
~25% maltodextrin and 0.1~0.5% CMC-Na, it is spare in 5~15min of 20MPa~30MPa homogeneous；
S5, with 145~220 DEG C of inlet temperature, 40~75 DEG C of outlet temperature, 0.5~1.2m of intake3/ min, feeding temperature 35~
70 DEG C of parameter is spray-dried homogeneous object made from above-mentioned S4, extract obtained fine powder, crosses 200 mesh sieve, is vacuum-packed,
The anti-fog haze solid beverage of every bag of 10g, as Exocarpium Citri Rubrum Sugarless type.
5. the preparation method of the anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type according to claim 4, it is characterised in that：The Exocarpium Citri Rubrum
Active principle is aurantiin and Rhoifolin, and Siraitia grosvenorii active principle is momordica glycoside V, using high effective liquid chromatography for measuring
Aurantiin, Rhoifolin and momordica glycoside V content, it is desirable that naringin content >=6.40%, Rhoifolin content >=4.70%,
Momordica glycoside V content >=12.50%.
6. the preparation method of the anti-fog haze solid beverage of Exocarpium Citri Rubrum Sugarless type according to claim 4, it is characterised in that：The arhat
Fruit is the Siraitia grosvenorii that vacuum dehydration to water content is 14%~34%.
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| CN112903835A (en) * | 2021-01-12 | 2021-06-04 | 广州泽力医药科技有限公司 | Fingerprint spectrum construction method and detection method of momordica grosvenori and red tangerine peel solid beverage |
| WO2023012283A1 (en) * | 2021-08-04 | 2023-02-09 | Esserre Pharma Srl | Plant extract-based composition and its use for treating glucose metabolism disorders |
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| CN104146220A (en) * | 2013-05-16 | 2014-11-19 | 史安宝 | Cucumber powder and processing method thereof |
| CN103330026A (en) * | 2013-06-14 | 2013-10-02 | 莫丕向 | Tea formula |
| CN103610205A (en) * | 2013-11-28 | 2014-03-05 | 刘菊 | Method for preparing bitter gourd instant beverage |
| CN105360522A (en) * | 2015-12-03 | 2016-03-02 | 彭楚铭 | Special health-care tea capable of clearing lung, for fog and haze |
| CN105663362A (en) * | 2016-03-07 | 2016-06-15 | 广东美华农业生物科技有限公司 | Citri grandis decoction piece and preparation method thereof |
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| CN112903835A (en) * | 2021-01-12 | 2021-06-04 | 广州泽力医药科技有限公司 | Fingerprint spectrum construction method and detection method of momordica grosvenori and red tangerine peel solid beverage |
| CN112903835B (en) * | 2021-01-12 | 2022-08-12 | 广州泽力医药科技有限公司 | Fingerprint spectrum construction method and detection method of momordica grosvenori and red tangerine peel solid beverage |
| WO2023012283A1 (en) * | 2021-08-04 | 2023-02-09 | Esserre Pharma Srl | Plant extract-based composition and its use for treating glucose metabolism disorders |
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