CN108602848B - 1，1’-硫烷二基-二-β-D-吡喃半乳糖苷作为半乳糖凝集素的抑制剂 - Google Patents

1，1’-硫烷二基-二-β-D-吡喃半乳糖苷作为半乳糖凝集素的抑制剂 Download PDF

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Publication number
CN108602848B
CN108602848B CN201680076549.6A CN201680076549A CN108602848B CN 108602848 B CN108602848 B CN 108602848B CN 201680076549 A CN201680076549 A CN 201680076549A CN 108602848 B CN108602848 B CN 108602848B
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galectin
compound
group
formula
alkyl
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Chinese (zh)
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CN108602848A (zh
Inventor
F·塞特贝里
U·尼尔松
H·莱弗勒
A·彼得森
H·尚比
T·布里默特
R·约翰森
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Galecto Biotech AB
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Galecto Biotech AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201680076549.6A 2015-11-09 2016-11-08 1，1’-硫烷二基-二-β-D-吡喃半乳糖苷作为半乳糖凝集素的抑制剂 Expired - Fee Related CN108602848B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15193657.2 2015-11-09
EP15193657 2015-11-09
EP16172358 2016-06-01
EP16172358.0 2016-06-01
PCT/EP2016/076918 WO2017080973A1 (en) 2015-11-09 2016-11-08 1,1 '-sulfanediyl-di-beta-d-galactopyranosides as inhibitors of galectins

Publications (2)

Publication Number Publication Date
CN108602848A CN108602848A (zh) 2018-09-28
CN108602848B true CN108602848B (zh) 2022-01-18

Family

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CN201680076549.6A Expired - Fee Related CN108602848B (zh) 2015-11-09 2016-11-08 1，1’-硫烷二基-二-β-D-吡喃半乳糖苷作为半乳糖凝集素的抑制剂

Country Status (7)

Country Link
US (1) US10730902B2 (https=)
EP (1) EP3374368B1 (https=)
JP (1) JP6892859B2 (https=)
CN (1) CN108602848B (https=)
CA (1) CA3000924A1 (https=)
ES (1) ES2921500T3 (https=)
WO (1) WO2017080973A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3025867A1 (en) * 2016-07-12 2018-01-18 Galecto Biotech Ab Alpha-d-galactoside inhibitors of galectins
CA3062648A1 (en) 2017-05-12 2018-11-15 Galectin Sciences, Llc Compounds for the prevention and treatment of diseases and the use thereof
AU2018308088B2 (en) * 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
WO2019067702A1 (en) 2017-09-27 2019-04-04 Bristol-Myers Squibb Company INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3
WO2019075045A1 (en) 2017-10-11 2019-04-18 Bristol-Myers Squibb Company INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3
CN111566117A (zh) 2017-12-29 2020-08-21 糖模拟物有限公司 E-选择蛋白和半乳凝素-3的异双功能抑制剂
JP7190513B2 (ja) 2018-06-15 2022-12-15 ブリストル－マイヤーズ スクイブ カンパニー ガレクチン－３抑制剤を模したテトラヒドロピラン系チオ二糖類
JP2022511094A (ja) 2018-12-06 2022-01-28 ブリストル－マイヤーズ スクイブ カンパニー ガレクチン－３の低分子阻害剤
CN118373810A (zh) 2018-12-27 2024-07-23 糖模拟物有限公司 抑制c-糖苷的半乳凝素-3
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
AU2020214796A1 (en) 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
WO2021081881A1 (zh) * 2019-10-31 2021-05-06 深圳先进技术研究院 一种基于tdg分子骨架的功能糖类分子及其制备方法
CN113521283A (zh) * 2020-04-14 2021-10-22 中国医学科学院药物研究所 Galectin-3作为靶标在寻找保护胰岛功能药物或者生物制剂中的应用
KR20230006547A (ko) 2020-05-05 2023-01-10 브리스톨-마이어스 스큅 컴퍼니 갈렉틴-3의 소분자 억제제
EP4149939A1 (en) 2020-05-11 2023-03-22 Bristol-Myers Squibb Company Small molecule inhibitors of galectin-3
WO2021242776A2 (en) 2020-05-26 2021-12-02 Truebinding, Inc. Methods of treating inflammatory diseases by blocking galectin-3
EP4157833A1 (en) 2020-05-28 2023-04-05 Bristol-Myers Squibb Company Galectin-3 inhibitors
US20240059728A1 (en) * 2021-02-10 2024-02-22 Galecto Biotech Ab Novel galactoside inhibitor of galectins

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002057284A1 (en) * 2001-01-22 2002-07-25 Ulf Nilsson New inhibitors against galectins
WO2005113569A1 (en) * 2004-05-21 2005-12-01 Forskapatent I Syd Ab Novel 3-triazolyl-galactoside inhibitors of galectins
CN102066393A (zh) * 2008-05-16 2011-05-18 佛斯卡专利公司 半乳糖苷抑制剂的新颖的合成
CN102439021A (zh) * 2009-04-28 2012-05-02 南方佛斯卡专利公司 半乳凝素的新型半乳糖苷抑制剂
CN104755088A (zh) * 2012-10-31 2015-07-01 格莱克特生物技术公司 半乳凝集素-3的半乳糖苷抑制剂及其用于治疗肺纤维化的应用
CN104955471A (zh) * 2012-11-15 2015-09-30 塔夫斯大学 使用半乳糖凝集素蛋白抑制剂用于治疗、调节或预防受试者的眼部血管生成或者纤维化的方法、组合物以及试剂盒
WO2016005311A1 (en) * 2014-07-09 2016-01-14 Galecto Biotech Ab Novel hybrid galactoside inhibitor of galectins
WO2016113335A1 (en) * 2015-01-16 2016-07-21 Galecto Biotech Ab Novel galactoside inhibitor of galectins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0401300D0 (sv) 2004-05-21 2004-05-21 Forskarpatent I Syd Ab Novel Galactoside Inhibitors of Galectins
US8828971B2 (en) 2012-10-10 2014-09-09 Galectin Therapeutics, Inc. Galactose-pronged carbohydrate compounds for the treatment of diabetic nephropathy and associated disorders
JP6904906B2 (ja) 2015-01-30 2021-07-21 ガレクト・バイオテック・エイビイ ガレクチンの新規なガラクトシド阻害剤

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002057284A1 (en) * 2001-01-22 2002-07-25 Ulf Nilsson New inhibitors against galectins
WO2005113569A1 (en) * 2004-05-21 2005-12-01 Forskapatent I Syd Ab Novel 3-triazolyl-galactoside inhibitors of galectins
CN102066393A (zh) * 2008-05-16 2011-05-18 佛斯卡专利公司 半乳糖苷抑制剂的新颖的合成
CN102439021A (zh) * 2009-04-28 2012-05-02 南方佛斯卡专利公司 半乳凝素的新型半乳糖苷抑制剂
CN104755088A (zh) * 2012-10-31 2015-07-01 格莱克特生物技术公司 半乳凝集素-3的半乳糖苷抑制剂及其用于治疗肺纤维化的应用
CN104955471A (zh) * 2012-11-15 2015-09-30 塔夫斯大学 使用半乳糖凝集素蛋白抑制剂用于治疗、调节或预防受试者的眼部血管生成或者纤维化的方法、组合物以及试剂盒
WO2016005311A1 (en) * 2014-07-09 2016-01-14 Galecto Biotech Ab Novel hybrid galactoside inhibitor of galectins
WO2016113335A1 (en) * 2015-01-16 2016-07-21 Galecto Biotech Ab Novel galactoside inhibitor of galectins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors;Bader A. Salameh, et al.;《Bioorganic & Medicinal Chemistry》;20100520;第18卷;第5367-5378页 *

Also Published As

Publication number Publication date
CN108602848A (zh) 2018-09-28
EP3374368B1 (en) 2022-06-01
CA3000924A1 (en) 2017-05-18
ES2921500T3 (es) 2022-08-26
WO2017080973A1 (en) 2017-05-18
US10730902B2 (en) 2020-08-04
US20180327440A1 (en) 2018-11-15
EP3374368A1 (en) 2018-09-19
JP2018534301A (ja) 2018-11-22
JP6892859B2 (ja) 2021-06-23

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