CN108593489B - 3D printing magnesium alloy material degradability testing device and application - Google Patents
3D printing magnesium alloy material degradability testing device and application Download PDFInfo
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Abstract
The invention discloses a device for testing degradability of a 3D printing magnesium alloy biological material, which comprises a heart bionic cabin, a sample loading device and a pretreatment device, wherein the heart bionic cabin is fixed on a support; the heart bionic cabin is divided into two independent areas by a non-porous bionic valve plate, the independent areas are respectively provided with a porous bionic valve plate, the two sides of the bottom of the independent areas are provided with outlets and are connected with a liquid storage tank by a power pump, the liquid storage tank is connected with a temperature control system, and the heart bionic cabin is also connected with a temperature detector, a hydrogen detector, a pressure sensor, a gas storage tank, a PH automatic control system and an alarm; a rotating shaft is arranged on the upper support, the sample carrying device is arranged on the rotating shaft and comprises a speed regulating motor, one end of an output shaft of the speed regulating motor is fixed with a drill chuck, and a sample loader is arranged on the drill chuck; the pretreatment device comprises an ultrasonic device, a drying box and a weighing device. The invention has high automation degree, can accurately simulate the degradation behavior of the implanted material in the human body, and has convenient and quick test and accurate and visual result.
Description
Technical Field
The invention belongs to the field of biomedicine, and relates to a device for testing degradability of a 3D printing magnesium alloy material and application thereof.
Background
The magnesium alloy has the advantages of good mechanical property, biocompatibility, degradability in human body physiological fluid and the like, and is expected to become an ideal biomedical metal material. With the development of the 3D printing technology, the magnesium alloy biomaterial with completely fitted shape and size can be prepared by the technology, and customization is realized. However, for materials implanted into a human body, such as bone nails, artificial bones, scaffolds and the like, in the service process, the research on the corrosion degradation behavior of the implanted materials in the body is complex in program flow, harsh in test environment and conditions and difficult to realize, and the corrosion degradation behavior of the implanted materials can be intuitively reflected by establishing an extracorporeal circulation system to simulate the corrosion degradation behavior of the implanted materials, so that the operability is strong and the controllability is high.
The degradation of the implanted material in the body is a closed, sterile and constant-temperature process, most of the existing dynamic simulation test devices do not consider the degradation process, and the influence of factors such as blood flow rate, blood pressure and the like in the body on the implanted material is generally considered when the degradation behavior in the body is accurately simulated. The Chinese patent application No. 201010265183.1 discloses a device for dynamically simulating and testing the biodegradability of magnesium alloy medical instruments in vitro, wherein a horizontal motion platform is introduced to drive an upper sample carrier fixed on the horizontal motion platform to clamp a sample to move, the motion of the sample in a fluid medium is reflected in the process, but the motion state of the medium cannot intuitively reflect the corrosion behavior of the material, and the flow velocity, stability and turbulence of the medium have different influences on the corrosion of the material.
The flow of blood in human blood vessels is a complex process, implanted materials can be subjected to the shearing action of blood, the influence of the blood flow rate and the like on the corrosion performance of the implanted materials is a problem to be solved urgently, the change of the parameters is lower for the visualization of the corrosion degradation behavior of the implanted materials in the human body, dynamic simulation test equipment which is suitable for the biodegradation characteristic of the magnesium alloy is designed and developed, and the dynamic simulation test equipment has higher operability, controllability and the like and is the key point for the research and development of biomedical magnesium alloy technology.
Disclosure of Invention
The invention provides a device for testing degradability of a magnesium alloy material through 3D printing, which aims to solve the problems of inaccurate test result and non-visual result of the existing in-vitro testing equipment for biodegradability of a magnesium alloy medical instrument.
The invention further aims to provide application of the degradation testing device for the 3D printing magnesium alloy material.
The invention is realized by the following technical scheme:
A3D printing magnesium alloy biomaterial degradability testing device comprises a heart bionic cabin, a sample loading device and a preprocessing device, wherein the heart bionic cabin is fixed on a support;
a non-porous bionic valve plate is fixed in the middle position inside the bionic heart cabin, the bionic heart cabin is divided into two independent areas which are not communicated with each other left and right by the non-porous bionic valve plate, the bionic heart cabin on two sides of the non-porous bionic valve plate is respectively provided with a porous bionic valve plate, two sides of the bottom of the bionic heart cabin are respectively provided with an outlet, the two outlets are respectively connected with a liquid supply pipeline provided with a flowmeter and a liquid storage tank through two power pumps, the liquid storage tank is connected with a temperature control system, and the bionic heart cabin is also respectively connected with a temperature detector, a hydrogen detector, a pressure sensor, a gas storage tank, a PH automatic control system and an alarm;
a rotating shaft is arranged on a support at the upper part of the heart bionic cabin, the sample carrying device is arranged on the rotating shaft and comprises a speed regulating motor arranged on the rotating shaft, one end of an output shaft of the speed regulating motor is fixed with a drill chuck, and two sample carriers are clamped on the drill chuck;
the pretreatment device comprises an ultrasonic device, a drying box and a weighing device which are fixed in sequence and are arranged on one side of the bionic heart cabin below the rotating shaft.
Furthermore, the power pump is a variable flow power pump, the flowmeter is a high-precision flowmeter, the liquid supply pipeline is a transparent elastic hose, the variable flow power pump is fixed in the liquid storage tank, and the high-precision flowmeter is arranged at the tail end of the transparent elastic hose close to the heart bionic cabin; the whole degradation process is completed in the heart bionic cabin, and a circulating system is composed of the heart bionic cabin, a liquid storage tank, a variable flow power pump, a transparent elastic hose and a high-precision flowmeter.
The liquid storage tank is fixed on the lower part of the heart bionic cabin and made of organic glass with the thickness of 15mm, and the heart bionic cabin is of a rectangular structure, a cylindrical structure or a wide-mouth bottle-shaped structure and is also made of organic glass with the thickness of 15 mm.
The bionic valvular plate without holes is formed by processing bioplastic, the two sample carriers are respectively arranged in the areas of the bionic cardiac chambers on the left and right sides, the 3D printed magnesium alloy block test sample is fixed on a gripper at the tail end of the sample carrier, outlets are respectively arranged at the bottoms of the left and right sides of the bionic cardiac chambers and are connected with the liquid storage tank through liquid supply pipelines, two power pumps are arranged in the liquid storage tank and are arranged side by side and respectively used for controlling the flow, the flow speed and the pressure of cardiac artery and venous blood input on the left and right sides.
The heart bionic cabin of sclausura bionic valve board both sides in be provided with three porous bionic valve board respectively, the one end of three porous bionic valve board is fixed in left side, right side, the rear side of heart bionic cabin respectively, the other end all is fixed in the top of heart bionic cabin, porous bionic valve board make by biomaterial, thickness is 0.2mm, the punchhole is circular, square, pentagon or hexagon etc. the aperture is 3-8mm, the face porosity is 50-70%.
The heart bionic cabin is characterized by further comprising an industrial high-speed camera, a control system and a terminal display device, wherein the industrial high-speed camera is installed right in front of the heart bionic cabin and is connected with the terminal display device through the control system, the alarm is connected with the control system, and the terminal display device can be a computer or a mobile phone;
the end of the sample carrier is provided with an arc-shaped gripping structure, the outer layer of the gripping structure is coated with an insulating layer, the whole operation process is completed by adopting a thinner arc-shaped gripping structure, the gripping is sheathed with the insulating layer, the fine degree of the gripping can maximize the surface of the alloy exposed in the fluid, the data deviation in the test process is reduced, and the arc-shaped design ensures that the sample is more firmly clamped and has less influence on the flow characteristic of the fluid in the heart bionic cabin.
Furthermore, the 3D printing magnesium alloy biomaterial degradability testing device is applied to other biomedical alloys, particularly magnesium alloys.
The application of the magnesium alloy comprises the following steps:
(1) simulating the stress condition and the degradation rate of the implanted magnesium alloy by using ansys simulation software, optimizing the structure and the components of the implanted magnesium alloy, and then printing and forming the biological magnesium alloy by using a 3D printing device to obtain a sample;
(2) fixing a sample on a sample carrier, starting a speed regulating motor, driving the sample carrier to move to an ultrasonic device by the speed regulating motor, ultrasonically cleaning for 5-10min, continuously driving the sample carrier to move to a drying device by the speed regulating motor, drying for 4-7min, continuously driving the sample carrier to move to a high-precision balance (the precision of the balance is 0.0001) by the speed regulating motor, and finishing initial weighing of the sample;
(3) adding a simulated blood solution into a liquid storage tank, starting a temperature control system, and heating to 37 +/-0.5 ℃ at a heating rate of 2-10 ℃/min; regulating the pH value of the simulated blood to 7.4 +/-0.05 by using a pH automatic control system, starting a power pump fixed in a liquid storage tank, and controlling the outlet flow speed of the simulated blood passing through the power pump and a high-precision flowmeter to be 14 cm/s;
(4) driving the sample carrier to move to the position close to the right of the center of the heart bionic cabin by a speed regulating motor, closing the speed regulating motor, opening a gas storage tank, introducing carbon dioxide gas into the heart bionic cabin, starting a pressure sensor, adjusting the pressure value of the position of the sample to be 15kpa, and monitoring the pressure of the position of the alloy in real time by a control system;
(5) opening a hydrogen detector and an alarm, and setting the hydrogen content value in the alarm to be 0.01 (ml/cm 2) d-1 (the corrosion rate of the magnesium alloy is related to the hydrogen evolution amount); adjusting the distance between the camera and the sample to achieve the optimal photographing distance, and feeding back the information of the picture photographed by the camera to the control system;
(6) after the control system receives the picture information, the corrosion morphology of the alloy surface is obtained through a processing software computer image recognition technology, and the corrosion behavior of the alloy is analyzed;
(7) when the hydrogen value reaches the set value, triggering an alarm, restarting a speed regulating motor, carrying out ultrasonic treatment (ultrasonic treatment is carried out for 5-10min in 200g/LCrO3 and 10g/LAgNO3 solutions), drying (drying for 4-7min), weighing (the precision of a balance is 0.0001), calculating the weight loss rate of the alloy, introducing the weight loss rate data obtained by calculation into a control system, and comprehensively analyzing the degradability of the alloy by combining the alloy surface corrosion morphology obtained by the control system.
The working principle of the invention is as follows: before testing, starting the speed regulating motor, driving the sample carrier to horizontally move to the ultrasonic device at the rotating shaft by the speed regulating motor, carrying out surface treatment on the alloy, after the surface treatment is finished, continuously driving the sample carrier to move to the drying box, carrying out drying treatment on the alloy (for preparing for subsequent weighing), adjusting the temperature of the drying box, after drying for 4-7 minutes, finishing the process, completing initial weighing of the tested alloy at a weighing device such as a high-precision place, finishing weighing, driving the sample carrier by the speed regulating motor to move to a position right to a heart bionic cabinTwo sample carriers are respectively fixed on two sides of a heart bionic cabin separated by a nonporous bionic valve plate, and a degradation test process is started; when a test is started, a temperature control system connected with a liquid storage tank adjusts the temperature of liquid in the liquid storage tank, wherein a simulation medium in the liquid storage tank simulates blood solution, the temperature control system is started before the test, the temperature of the liquid in the liquid storage tank is adjusted to 37 +/-0.5 ℃, a variable flow power pump provides power for a whole circulation loop, the whole circulation loop is communicated through a transparent elastic hose, a high-precision flowmeter is arranged at the outlet end of the transparent elastic hose, the flow of the liquid flowing into a heart bionic cabin is precisely controlled, and the flow velocity of a fluid medium passing through the power pump and the outlet of the high-precision flowmeter is controlled to be about 14 cm/s; the temperature detector connected with the heart bionic cabin detects the temperature of the fluid in the heart bionic cabin, if deviation exists, the temperature can be adjusted by the adjusting temperature control system, and the temperature is based on the temperature of the fluid in the heart bionic cabin; the hydrogen detector collects hydrogen generated in the degradation process and displays the hydrogen in real time through a display screen; the pressure sensor detects the pressure in the whole system and maintains a certain pressure in the system, (the blood pressure value of the internal vein of the human body is 15kpa, and the simulation is more real); the carbon dioxide gas in the gas storage tank can be precisely controlled by a gas flowmeter according to the quantity of the carbon dioxide in the human body; the PH automatic control system adjusts the PH of the fluid in the heart bionic cabin to 7.4 +/-0.05 in real time; the industrial high-speed camera shoots the degradation process in real time, transmits the shot whole degradation process to the control system, and is finally connected to the control system through a terminal display (such as a mobile phone) to check and monitor the whole degradation process; the alarm can set time and hydrogen quantity, when the corresponding time and hydrogen quantity are reached, the alarm is triggered and fed back to the control system to remind workers that the degradation process is finished and follow-up operation is carried out; after degradation, repeating the ultrasonic treatment, drying treatment and weighing processes before testing to complete the whole degradation process; the non-porous bionic valve plate is set based on the principle that artery and vein in human body are not communicated, the non-porous bionic valve plate is utilized to divide the heart bionic cabin into two independent areas which are not communicated with each other at left and right, wherein the left area simulates the heart artery blood flow process, the right area simulates the heart vein blood flow process, and the left area simulates the heart vein blood flow processIn the flowing process of arterial blood, the flow speed and the pressure of a heart blood inlet and outlet are simulated by controlling a pump body, the flow speed is 18-22cm/s, the pressure of a position where a magnesium alloy block test sample is printed in a 3D mode is 14kpa, the flowing process of cardiac venous blood is simulated in a right side area, the flow speed and the pressure of the heart blood inlet and outlet are simulated by controlling the pump body, the flow speed is 7-8cm/s, and the pressure of the position where the magnesium alloy block test sample is printed in the 3D mode is 1 kpa; the porous bionic valve plate simulates a valve between a heart and an aorta and a vein, is similar to a one-way valve, ensures that blood flows at a certain flow rate in a certain direction without flowing back, can simulate the opening and closing according to the rhythmicity of the heart of a human body, pushes the blood to circulate in a single direction, generally contracts and relaxes about 70 times per minute of the heart, has the blood pulsation volume of 70 milliliters each time, has the blood pulsation volume of about 5 liters per 1 minute of the heart, and outputs the pulsating blood per second (namely the aorta volume) Q =8.3x10-5m3And/s, due to the porous design, when blood flows through the porous valve plate, no vortex exists, the cross-valve pressure difference is close to zero, and the blood flow is ensured to flow in a certain direction and a certain steady flow mode without flowing backwards.
Compared with the prior art, the invention has the following advantages:
1) the nonporous bionic valve plate and the porous bionic valve plate are made of biological materials, so that the durability is good, the compatibility with an organism is good, the thrombus-resisting effect is good, the blood components are not damaged, and no obvious rejection reaction exists;
2) the transparent elastic hose is used as a substitute for a simulated blood vessel to convey a medium, because the blood vessel in a human body has elasticity and expansibility, and the transparent elastic hose can reduce the pulsation of fluid and ensure the continuous flow of the fluid;
3) the gas storage tank is used for storing gases such as carbon dioxide and the like contained in human bodies, so that the degradation process of the implant material can be simulated really;
4) a PH automatic control system is added, so that the PH value of the fluid in the circulation loop can be automatically controlled, and the PH is kept constant;
5) before and after the test, the alloy treatment process can utilize a motor to drive a sample loader for clamping a sample to perform operations such as ultrasonic treatment, drying, weighing and the like, and the automation degree is higher;
6) the liquid medium circulation loop is formed by connecting a heart bionic cabin and a liquid storage tank which are arranged up and down through an elastic transparent hose, and the hydrogen generated in the whole degradation process can be directly collected through a hydrogen detector in such a placement mode, so that the degradation rate of the alloy is visually reflected; the industrial high-speed camera can directly shoot the whole degradation process, and the visualization degree is high.
In summary, the invention has high automation degree, can accurately simulate the degradation behavior of the implanted material in the human body, and has convenient and rapid test and accurate and visual result.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic diagram of the sample carrier;
FIG. 3 is a schematic cross-sectional view of a bionic cardiac chamber;
FIG. 4 is a schematic structural view of a porous biomimetic valve plate;
FIG. 5 is a schematic structural view of a bionic cardiac chamber in example 2;
in the figure: the method comprises the following steps of 1-a speed regulating motor, 2-a rotating shaft, 3-a weighing device, 4-a drying box, 5-an ultrasonic device, 6-a temperature control system, 7-a temperature detector, 8-a flow meter, 9-a liquid supply pipeline, 10-a hydrogen detector, 11-a heart bionic cabin, 12-a sample carrier, 13-a porous bionic valve plate, 14-a power pump, 15-a liquid storage tank, 16-an industrial high-speed camera, 17-a control system, 18-a PH automatic control system, 19-a gas storage tank, 20-a gas flow meter, 21-an alarm, 22-a pressure sensor, 23-a drill chuck, 24-a support, 25-a high-precision flow meter and 26-a nonporous bionic valve plate.
Detailed Description
The present invention is further described below with reference to specific examples and drawings, but it should be understood that these examples are only for illustrating the present invention and are not intended to limit the scope of the present invention. Various changes or modifications of the present invention based on the present invention should be made by those skilled in the art within the scope of the present invention.
Example 1
The device for testing the degradability of the 3D printed magnesium alloy biomaterial shown in the figures 1, 2 and 3 comprises a heart bionic cabin 11 fixed on a bracket 24, a sample loading device and a pretreatment device; a non-porous bionic valve plate 26 is fixed in the middle of the inside of the bionic heart chamber 11, the bionic heart chamber 11 is divided into two independent areas which are not communicated with each other left and right by the non-porous bionic valve plate 26, porous bionic valve plates 13 are respectively arranged in the bionic heart chambers on two sides of the non-porous bionic valve plate 26, outlets are respectively arranged on two sides of the bottom of the bionic heart chamber 11, the outside of the bionic heart chamber is connected with a liquid storage tank 15 through two power pumps 14 and a liquid supply pipeline 9 provided with a flow meter 8 and a high-precision flow joint 25, the liquid storage tank 15 is connected with a temperature control system 6, and the bionic heart chamber 11 is further respectively connected with a temperature detector 7, a hydrogen detector 10, a pressure sensor 22, a gas storage tank 19 provided with a gas flow meter 20, a PH automatic control system 18; a rotating shaft 2 is arranged on a support at the upper part of the heart bionic cabin 11, the sample carrying device is arranged on the rotating shaft 2 and comprises a speed regulating motor 1 arranged on the rotating shaft 2, a drill chuck 23 is fixed at one end of an output shaft of the speed regulating motor 1, and two sample carriers 12 are clamped on the drill chuck 23; the pretreatment device comprises an ultrasonic device 5, a drying box 4 and a weighing device 3 which are fixed in sequence and are arranged on one side of the bionic heart cabin below the rotating shaft 2.
The non-porous bionic valve plate 26 is made of biological plastics, and the two sample carriers 12 are respectively arranged in the areas of the left and right heart bionic cabins 11; three porous bionic valve plates 26 are respectively arranged in the heart bionic cabin on two sides of each non-porous bionic valve plate 26, one ends of the three porous bionic valve plates 26 are respectively fixed on the left side, the right side and the rear side of the heart bionic cabin 11, the other ends of the three porous bionic valve plates are respectively fixed on the top of the heart bionic cabin, each porous bionic valve plate 13 is made of a biological material, the structure is shown in figure 4, the thickness is 0.2mm, holes are circular, square, pentagonal or hexagonal, and the like, the aperture is 3-8mm, and the porosity of the plate surface is 50-70%; the power pump 14 is a variable flow power pump, the flowmeter 8 is a high-precision flowmeter, the liquid supply pipeline 9 is a transparent elastic hose, the variable flow power pump is fixed in the liquid storage tank 15, and the high-precision flowmeter is arranged at the tail end of the transparent elastic hose close to the heart bionic cabin 11; the liquid storage tank 15 is fixed at the lower part of the heart bionic cabin 11 and is made of 15mm thick organic glass, and the heart bionic cabin is rectangular and is made of 15mm thick organic glass; the tail end of the sample carrier 12 is of an arc-shaped gripping structure, the surface of the alloy exposed in the fluid can be maximized due to the fineness of the gripping structure coated with the insulating layer on the outer layer, the data deviation in the test process is reduced, the sample is more firmly clamped due to the arc-shaped design, and the influence on the flow characteristic of the fluid in the heart bionic cabin is less; the heart bionic cabin is characterized by further comprising an industrial high-speed camera 16, a control system 17 and a mobile phone, wherein the industrial high-speed camera 16 is installed right in front of the heart bionic cabin 11 and is in wireless connection with the mobile phone through the control system 17, and the alarm 21 is connected with the control system 17.
The testing steps are as follows:
(1) simulating the stress condition and the degradation rate of the AZ91D magnesium alloy by using ansys simulation software, optimizing the structure and the components of the AZ91D magnesium alloy, and then printing and forming the AZ91D biological magnesium alloy by using a 3D printing method;
(2) starting a power system for controlling the sample carrier, driving the sample carrier 12 to horizontally move on the rotating shaft 2 to the ultrasonic device 5 by the motor 1, carrying out surface treatment on the alloy, carrying out ultrasonic cleaning for 5-10min, after the surface treatment is finished, continuously driving the sample carrier 12 to move to the drying box 4 by the motor 1, carrying out drying treatment on the alloy (preparing for subsequent weighing), adjusting the temperature of the drying box 4, finishing the process after drying for 5min, finishing initial weighing of the tested alloy at the weighing device 3 (a high-precision balance with the precision of 0.0001), finishing weighing, driving the sample carrier 12 to move right above the heart bionic cabin by the motor 1, and starting a degradation test process;
(3) adding a simulated blood solution into the liquid storage tank 15, starting the temperature control system 6, fixing the temperature control system 6 on the left side of the liquid storage tank 15, and heating to 37 +/-0.5 ℃ at a heating rate of 2-10 ℃/min; adjusting the pH value of the simulated blood to 7.4 +/-0.05 by using an automatic pH control system 18, starting a power pump 14 fixed in a liquid storage tank 15 to provide power for the whole circulation loop, controlling the simulated blood to enter a heart bionic cabin 11 through the power pump 14, a flowmeter 8 and a high-precision flowmeter 15, and controlling the outlet flow speed of the high-precision flowmeter 15 to be 14 cm/s;
(4) the sample carrier 12 is driven by the speed regulating motor 1 to move to the position close to the right of the center of the heart bionic cabin 11, the speed regulating motor 1 is closed, the gas storage tank 19 is opened, carbon dioxide gas is introduced into the heart bionic cabin 11, the pressure sensor 22 is started, the pressure value of the position where the sample is located is adjusted to be 15kpa, and the control system 14 monitors the pressure of the position where the alloy is located in real time;
(5) opening a hydrogen detector and an alarm, and setting the hydrogen content value in the alarm to be 0.01 (ml/cm 2) d-1 (the corrosion rate of the magnesium alloy is related to the hydrogen evolution amount); adjusting the distance between the camera and the sample to achieve the optimal photographing distance, and feeding back the information of the picture photographed by the camera to the control system;
a hydrogen detector above the heart bionic cabin 11 collects hydrogen generated in the degradation process, the hydrogen is displayed in real time through a display screen, a pressure sensor 22 detects the pressure in the whole system and maintains the pressure in the system to be certain (the pressure in a human body is certain, the simulation is more real), and the PH of fluid in the heart bionic cabin can be adjusted to 7.4 in real time through a gas flow 20 precision control system and a PH automatic control system 18 according to the value of carbon dioxide in the human body; when the experiment is started, the volume of the fluid in the bionic heart chamber 11 is unchanged, the flow rate of the fluid medium is 14cm/s (the flow rate is consistent with the flow rate of blood in a human body) through the outlets of the flow meter 8 and the high-precision flow meter 25, and the pressure value of the position where the degradable material is located is adjusted to be 15kpa equal to the value of the blood pressure of the internal vein through the pressure sensor 22;
(6) after the control system receives the picture information, the corrosion morphology of the alloy surface is obtained through a processing software computer image recognition technology, and the corrosion behavior of the alloy is analyzed;
(7) when the hydrogen value reaches the set value, triggering an alarm, restarting a speed regulating motor, carrying out ultrasonic treatment (ultrasonic treatment is carried out for 5-10min in 200g/LCrO3 and 10g/LAgNO3 solutions), drying (drying for 4-7min), weighing (the precision of a balance is 0.0001), calculating the weight loss rate of the alloy, introducing the weight loss rate data obtained by calculation into a control system, and comprehensively analyzing the degradability of the alloy by combining the alloy surface corrosion morphology obtained by the control system.
Example 2
The device for testing the degradability of the 3D printed magnesium alloy biomaterial shown in the figures 1, 2 and 3 comprises a heart bionic cabin 11 fixed on a bracket 24, a sample loading device and a pretreatment device; a non-porous bionic valve plate 26 is fixed in the middle of the inside of the bionic heart chamber 11, the bionic heart chamber 11 is divided into two independent areas which are not communicated with each other left and right by the non-porous bionic valve plate 26, porous bionic valve plates 13 are respectively arranged in the bionic heart chambers on two sides of the non-porous bionic valve plate 26, outlets are respectively arranged on two sides of the bottom of the bionic heart chamber 11, the outside of the bionic heart chamber is connected with a liquid storage tank 15 through two power pumps 14 and a liquid supply pipeline 9 provided with a flow meter 8 and a high-precision flow joint 25, the liquid storage tank 15 is connected with a temperature control system 6, and the bionic heart chamber 11 is further respectively connected with a temperature detector 7, a hydrogen detector 10, a pressure sensor 22, a gas storage tank 19 provided with a gas flow meter 20, a PH automatic control system 18; a rotating shaft 2 is arranged on a support at the upper part of the heart bionic cabin 11, the sample carrying device is arranged on the rotating shaft 2 and comprises a speed regulating motor 1 arranged on the rotating shaft 2, a drill chuck 23 is fixed at one end of an output shaft of the speed regulating motor 1, and two sample carriers 12 are clamped on the drill chuck 23; the pretreatment device comprises an ultrasonic device 5, a drying box 4 and a weighing device 3 which are fixed in sequence and are arranged on one side of the bionic heart cabin below the rotating shaft 2.
The non-porous bionic valve plate 26 is made of biological plastics, and the two sample carriers 12 are respectively arranged in the areas of the left and right heart bionic cabins 11; three porous bionic valve plates 26 are respectively arranged in the heart bionic cabin on two sides of each non-porous bionic valve plate 26, one end of each porous bionic valve plate 26 is respectively fixed on the left side, the right side and the rear side of the heart bionic cabin 11, the other end of each porous bionic valve plate is fixed on the top of the heart bionic cabin, each porous bionic valve plate 13 is made of a biological material, the thickness of each porous bionic valve plate is 0.2mm, the holes are round, square, pentagonal or hexagonal, the aperture is 3-8mm, and the porosity of the plate surface is 50-70%; the power pump 14 is a variable flow power pump, the flowmeter 8 is a high-precision flowmeter, the liquid supply pipeline 9 is a transparent elastic hose, the variable flow power pump is fixed in the liquid storage tank 15, and the high-precision flowmeter is arranged at the tail end of the transparent elastic hose close to the heart bionic cabin 11; as shown in fig. 5, the heart bionic cabin is cylindrical and is made of organic glass with the thickness of 15 mm; the power pump is a variable flow power pump, the flowmeter is a high-precision flowmeter, the liquid supply pipeline is a transparent elastic hose, the variable flow power pump is fixed in the liquid storage tank, and the high-precision flowmeter is arranged at the tail end of the transparent elastic hose close to the heart bionic cabin; the liquid storage tank is fixed at the lower part of the heart bionic cabin and is made of organic glass with the thickness of 15 mm; the heart bionic cabin is characterized by further comprising an industrial high-speed camera, a control system and a computer, wherein the industrial high-speed camera is installed right ahead the heart bionic cabin and is in wired or wireless connection with the computer through the control system, and the alarm is connected with the control system.
The testing steps are as follows:
(1) simulating the stress condition and the degradation rate of the AZ91D magnesium alloy by using ansys simulation software, optimizing the structure and the components of the AZ91D magnesium alloy, and then printing and forming the AZ91D biological magnesium alloy by using a 3D printing method;
(2) starting a speed regulating motor, driving a sample carrier to move to an ultrasonic device by the speed regulating motor, carrying out ultrasonic cleaning for 5min, after the ultrasonic cleaning is finished, continuously driving the sample carrier to move to a drying device by the speed regulating motor, drying for 4min, and after the drying is finished, continuously driving the sample carrier to move to a high-precision balance (the precision of the balance is 0.0001) by the speed regulating motor to finish the initial weighing of the sample;
(3) adding the simulated blood solution into the liquid storage tank, starting a temperature control system, raising the temperature at a rate of 3 ℃/min to 36.5 ℃, and keeping the temperature constant. Regulating the pH value of the simulated blood to 7.4 by using a pH automatic control system, starting a power pump fixed in a liquid storage tank, and controlling the outlet flow speed of the simulated blood passing through the power pump and a high-precision flowmeter to be 14 cm/s;
(4) the speed regulating motor drives the sample carrier to move to the position close to the right of the center of the heart bionic cabin, the speed regulating motor is closed, the gas storage tank is opened, carbon dioxide gas is introduced into the heart bionic cabin, the pressure sensor is started, the pressure value of the position where the alloy is located is regulated to be 15kpa, and the control system monitors the pressure of the position where the alloy is located in real time;
(5) opening a hydrogen detector and an alarm, and setting the hydrogen content value in the alarm to be 0.01 (ml/cm 2) d-1 (the corrosion rate of the magnesium alloy is related to the hydrogen evolution amount);
(6) adjusting the distance between the camera and the alloy to achieve the optimal photographing distance, and feeding back the information of the picture photographed by the camera to the control system;
(7) after receiving the picture information, the control system obtains the surface corrosion morphology of the alloy through a processing software computer image recognition technology; and analyzing the corrosion behavior of the alloy by the control system according to the obtained corrosion morphology of the alloy surface. Then storing the information to provide guidance for subsequent magnesium alloy component design;
(8) when the hydrogen value reaches the set value, an alarm is triggered to remind a worker that the current experiment is finished, the speed regulating motor is restarted, ultrasonic treatment is carried out (ultrasonic treatment is carried out for 5min in 200g/LCrO3 and 10g/LAgNO3 solution), drying is carried out for 4min, weighing is carried out (the precision of a balance is 0.0001), the weight loss rate of the alloy is calculated, the calculated weight loss rate data is led into a control system, the corrosion morphology of the surface of the alloy is obtained by combining the control system, and the degradability of the alloy is comprehensively analyzed.
Example 3
The 3D printing magnesium alloy biomaterial degradability testing device shown in figures 1, 2 and 3 comprises a 3D printing magnesium alloy biomaterial degradability testing device fixed on figures 1, 2 and 3, and comprises a heart bionic cabin 11 fixed on a bracket 24, a sample loading device and a pretreatment device; a non-porous bionic valve plate 26 is fixed in the middle of the inside of the bionic heart chamber 11, the bionic heart chamber 11 is divided into two independent areas which are not communicated with each other left and right by the non-porous bionic valve plate 26, porous bionic valve plates 13 are respectively arranged in the bionic heart chambers on two sides of the non-porous bionic valve plate 26, outlets are respectively arranged on two sides of the bottom of the bionic heart chamber 11, the outside of the bionic heart chamber is connected with a liquid storage tank 15 through two power pumps 14 and a liquid supply pipeline 9 provided with a flow meter 8 and a high-precision flow joint 25, the liquid storage tank 15 is connected with a temperature control system 6, and the bionic heart chamber 11 is further respectively connected with a temperature detector 7, a hydrogen detector 10, a pressure sensor 22, a gas storage tank 19 provided with a gas flow meter 20, a PH automatic control system 18; a rotating shaft 2 is arranged on a support at the upper part of the heart bionic cabin 11, the sample carrying device is arranged on the rotating shaft 2 and comprises a speed regulating motor 1 arranged on the rotating shaft 2, a drill chuck 23 is fixed at one end of an output shaft of the speed regulating motor 1, and two sample carriers 12 are clamped on the drill chuck 23; the pretreatment device comprises an ultrasonic device 5, a drying box 4 and a weighing device 3 which are fixed in sequence and are arranged on one side of the bionic heart cabin below the rotating shaft 2.
The non-porous bionic valve plate 26 is made of biological plastics, and the two sample carriers 12 are respectively arranged in the areas of the left and right heart bionic cabins 11; three porous bionic valve plates 26 are respectively arranged in the heart bionic cabin on two sides of each non-porous bionic valve plate 26, one end of each porous bionic valve plate 26 is respectively fixed on the left side, the right side and the rear side of the heart bionic cabin 11, the other end of each porous bionic valve plate is fixed on the top of the heart bionic cabin, each porous bionic valve plate 13 is made of a biological material, the thickness of each porous bionic valve plate is 0.2mm, the holes are round, square, pentagonal or hexagonal, the aperture is 3-8mm, and the porosity of the plate surface is 50-70%; the power pump 14 is a variable flow power pump, the flowmeter 8 is a high-precision flowmeter, the liquid supply pipeline 9 is a transparent elastic hose, the variable flow power pump is fixed in the liquid storage tank 15, and the high-precision flowmeter is arranged at the tail end of the transparent elastic hose close to the heart bionic cabin 11; the liquid storage tank 15 is fixed at the lower part of the heart bionic cabin 11 and is made of organic glass with the thickness of 15mm, and the heart bionic cabin 11 is of a wide-mouth bottle-shaped structure and is made of organic glass with the thickness of 15 mm; the power pump is a variable flow power pump, the flowmeter is a high-precision flowmeter, the liquid supply pipeline is a transparent elastic hose, the variable flow power pump is fixed in the liquid storage tank, and the high-precision flowmeter is arranged at the tail end of the transparent elastic hose close to the heart bionic cabin; the liquid storage tank is fixed at the lower part of the heart bionic cabin and is made of organic glass with the thickness of 15 mm; the heart bionic cabin is characterized by further comprising an industrial high-speed camera, a control system and a computer, wherein the industrial high-speed camera is installed right ahead the heart bionic cabin and is in wired or wireless connection with the computer through the control system, and the alarm is connected with the control system.
The application steps are as follows:
(1) simulating the stress condition and the degradation rate of the ZK30 magnesium alloy by using ansys simulation software, optimizing the structure and the components of the ZK30 magnesium alloy, and then printing and forming the ZK30 biological magnesium alloy by using a 3D printing method;
(2) starting a speed regulating motor, driving a sample carrier to move to an ultrasonic device by the speed regulating motor, carrying out ultrasonic cleaning for 7min, after the ultrasonic cleaning is finished, continuously driving the sample carrier to move to a drying device by the speed regulating motor, drying for 5min, and after the drying is finished, continuously driving the sample carrier to move to a high-precision balance (the precision of the balance is 0.0001) by the speed regulating motor to finish the initial weighing of the sample;
(3) adding the simulated blood solution into the liquid storage tank, starting a temperature control system, raising the temperature at a rate of 5 ℃/min to 36.8 ℃, and keeping the temperature constant. Regulating the pH value of the simulated blood to 7.4 by using a pH automatic control system, starting a power pump fixed in a liquid storage tank, and controlling the outlet flow speed of the simulated blood passing through the power pump and a high-precision flowmeter to be 14 cm/s;
(4) the speed regulating motor drives the sample carrier to move to the position close to the right of the center of the heart bionic cabin, the speed regulating motor is closed, the gas storage tank is opened, carbon dioxide gas is introduced into the heart bionic cabin, the pressure sensor is started, the pressure value of the position where the alloy is located is regulated to be 15kpa, and the control system monitors the pressure of the position where the alloy is located in real time;
(5) opening a hydrogen detector and an alarm, and setting the hydrogen content value in the alarm to be 0.01 (ml/cm 2) d-1 (the corrosion rate of the magnesium alloy is related to the hydrogen evolution amount);
(6) adjusting the distance between the camera and the alloy to achieve the optimal photographing distance, and feeding back the information of the picture photographed by the camera to the control system;
(7) after receiving the picture information, the control system obtains the surface corrosion morphology of the alloy through a processing software computer image recognition technology; and analyzing the corrosion behavior of the alloy by the control system according to the obtained corrosion morphology of the alloy surface. Then storing the information to provide guidance for subsequent magnesium alloy component design;
(8) when the hydrogen value reaches the set value, an alarm is triggered to remind a worker that the current experiment is finished, the speed regulating motor is restarted, ultrasonic treatment (ultrasonic treatment is carried out for 7min in 200g/LCrO3 and 10g/LAgNO3 solution), drying (drying for 5min), weighing (the precision of a balance is 0.0001) treatment is carried out, the weight loss rate of the alloy is calculated, the calculated weight loss rate data is led into a control system, the corrosion morphology of the surface of the alloy is obtained by combining the control system, and the degradability of the alloy is comprehensively analyzed.
Example 4
The application steps are as follows:
(1) simulating the stress condition and the degradation rate of Mg-Zn-Ca series magnesium alloy by using ansys simulation software, optimizing the structure and the components of the Mg-Zn-Ca magnesium alloy, and then printing and forming the Mg-Zn-Ca biological magnesium alloy by using a 3D printing method;
(2) starting a speed regulating motor, driving a sample carrier to move to an ultrasonic device by the speed regulating motor, carrying out ultrasonic cleaning for 8min, after the ultrasonic cleaning is finished, continuously driving the sample carrier to move to a drying device by the speed regulating motor, drying for 6min, and after the drying is finished, continuously driving the sample carrier to move to a high-precision balance (the precision of the balance is 0.0001) by the speed regulating motor to finish the initial weighing of the sample;
(3) adding the simulated blood solution into the liquid storage tank, starting a temperature control system, raising the temperature at a rate of 7 ℃/min to 37.2 ℃, and keeping the temperature constant. Regulating the pH value of the simulated blood to 7.4 by using a pH automatic control system, starting a power pump fixed in a liquid storage tank, and controlling the outlet flow speed of the simulated blood passing through the power pump and a high-precision flowmeter to be 14 cm/s;
(4) the speed regulating motor drives the sample carrier to move to the position close to the right of the center of the heart bionic cabin, the speed regulating motor is closed, the gas storage tank is opened, carbon dioxide gas is introduced into the heart bionic cabin, the pressure sensor is started, the pressure value of the position where the alloy is located is regulated to be 15kpa, and the control system monitors the pressure of the position where the alloy is located in real time;
(5) opening a hydrogen detector and an alarm, and setting the hydrogen content value in the alarm to be 0.01 (ml/cm 2) d-1 (the corrosion rate of the magnesium alloy is related to the hydrogen evolution amount);
(6) adjusting the distance between the camera and the alloy to achieve the optimal photographing distance, and feeding back the information of the picture photographed by the camera to the control system;
(7) after receiving the picture information, the control system obtains the surface corrosion morphology of the alloy through a processing software computer image recognition technology; and analyzing the corrosion behavior of the alloy by the control system according to the obtained corrosion morphology of the alloy surface. Then storing the information to provide guidance for subsequent magnesium alloy component design;
(8) when the hydrogen value reaches the set value, an alarm is triggered to remind a worker that the current experiment is finished, the speed regulating motor is restarted, ultrasonic treatment (ultrasonic treatment is carried out for 8min in 200g/LCrO3 and 10g/LAgNO3 solution), drying (drying for 6min), weighing (the precision of a balance is 0.0001) treatment is carried out, the weight loss rate of the alloy is calculated, the calculated weight loss rate data is led into a control system, the corrosion morphology of the surface of the alloy is obtained by combining the control system, and the degradability of the alloy is comprehensively analyzed.
Example 5
The application steps are as follows:
(1) simulating the stress condition and the degradation rate of Mg-Nd-Zn-Ca series magnesium alloy by using ansys simulation software, optimizing the structure and the components of the Mg-Nd-Zn-Ca magnesium alloy, and then printing and forming the Mg-Nd-Zn-Ca biological magnesium alloy by using a 3D printing method;
(2) starting a speed regulating motor, driving a sample carrier to move to an ultrasonic device by the speed regulating motor, carrying out ultrasonic cleaning for 10min, after the ultrasonic cleaning is finished, continuously driving the sample carrier to move to a drying device by the speed regulating motor, drying for 7min, and after the drying is finished, continuously driving the sample carrier to move to a high-precision balance (the precision of the balance is 0.0001) by the speed regulating motor to finish the initial weighing of the sample;
(3) adding the simulated blood solution into the liquid storage tank, starting a temperature control system, raising the temperature at a rate of 7 ℃/min to 37.3 ℃, and keeping the temperature constant. Regulating the pH value of the simulated blood to 7.35 by using a pH automatic control system, starting a power pump fixed in a liquid storage tank, and controlling the outlet flow speed of the simulated blood passing through the power pump and a high-precision flowmeter to be 14 cm/s;
(4) the speed regulating motor drives the sample carrier to move to the position close to the right of the center of the heart bionic cabin, the speed regulating motor is closed, the gas storage tank is opened, carbon dioxide gas is introduced into the heart bionic cabin, the pressure sensor is started, the pressure value of the position where the alloy is located is regulated to be 15kpa, and the control system monitors the pressure of the position where the alloy is located in real time;
(5) opening a hydrogen detector and an alarm, and setting the hydrogen content value in the alarm to be 0.01 (ml/cm 2) d-1 (the corrosion rate of the magnesium alloy is related to the hydrogen evolution amount);
(6) adjusting the distance between the camera and the alloy to achieve the optimal photographing distance, and feeding back the information of the picture photographed by the camera to the control system;
(7) after receiving the picture information, the control system obtains the surface corrosion morphology of the alloy through a processing software computer image recognition technology; and analyzing the corrosion behavior of the alloy by the control system according to the obtained corrosion morphology of the alloy surface. Then storing the information to provide guidance for subsequent magnesium alloy component design;
(8) when the hydrogen value reaches the set value, an alarm is triggered to remind a worker that the current experiment is finished, the speed regulating motor is restarted, ultrasonic treatment is carried out (ultrasonic treatment is carried out for 10min in 200g/LCrO3 and 10g/LAgNO3 solution), drying is carried out for 7min, weighing is carried out (the precision of a balance is 0.0001), the weight loss rate of the alloy is calculated, the calculated weight loss rate data is led into a control system, the corrosion morphology of the surface of the alloy is obtained by combining the control system, and the degradability of the alloy is comprehensively analyzed.
Claims (8)
1. A3D printing magnesium alloy biomaterial degradability testing device comprises a heart bionic cabin, a sample loading device and a preprocessing device, wherein the heart bionic cabin is fixed on a support;
a non-porous bionic valve plate is fixed in the middle position inside the heart bionic cabin, the non-porous bionic valve plate is processed by biological plastics,
the heart bionic cabin is divided into two independent areas which are not communicated with each other left and right by the nonporous bionic valve plate, three porous bionic valve plates are respectively arranged in the heart bionic cabin on two sides of the nonporous bionic valve plate, one ends of the three porous bionic valve plates are respectively fixed on the left side, the right side and the rear side of the heart bionic cabin, the other ends of the three porous bionic valve plates are respectively fixed on the top of the heart bionic cabin, the porous bionic valve plates are made of biological materials, the thickness of the porous bionic valve plates is 0.2mm, the holes are circular, square, pentagonal or hexagonal, the aperture is 3-8mm, and the porosity of the plate surface is 50-70%; outlets are arranged on two sides of the bottom of the heart bionic cabin and are respectively connected with a liquid supply pipeline provided with a flow meter through two power pumps, the liquid supply pipeline is connected with a liquid storage tank, the liquid storage tank is connected with a temperature control system, and the heart bionic cabin is also respectively connected with a temperature detector, a hydrogen detector, a pressure sensor, a gas storage tank, a PH automatic control system and an alarm;
a rotating shaft is arranged on a support at the upper part of the heart bionic cabin, the sample carrying device is arranged on the rotating shaft and comprises a speed regulating motor arranged on the rotating shaft, one end of an output shaft of the speed regulating motor is fixed with a drill chuck, and two sample carriers are clamped on the drill chuck;
the pretreatment device comprises an ultrasonic device, a drying box and a weighing device which are fixed in sequence and are arranged on one side of the bionic heart cabin below the rotating shaft.
2. The 3D printing magnesium alloy biomaterial degradability testing device of claim 1, characterized in that the power pump is a variable flow power pump, the flow meter is a high-precision flow meter, the liquid supply pipeline is a transparent elastic hose, the variable flow power pump is fixed in the liquid storage tank, and the high-precision flow meter is installed at the end of the transparent elastic hose close to the bionic chamber of the heart.
3. The 3D printing magnesium alloy biomaterial degradability test device of claim 1 or 2, characterized in that, the liquid storage tank is fixed at the lower part of the bionic heart chamber, the liquid storage tank and the bionic heart chamber are made of organic glass with the thickness of 15mm, and the bionic heart chamber is in a rectangular, cylindrical or jar-shaped structure.
4. The device for testing the degradability of the 3D printed magnesium alloy biomaterial according to claim 1, wherein the plurality of porous bionic valve plates are vertically fixed at the middle position inside the bionic heart cabin.
5. The 3D printing magnesium alloy biomaterial degradability test device according to claim 1 or 2, further comprising an industrial high-speed camera, wherein the industrial high-speed camera is installed right in front of the bionic heart cabin.
6. The 3D printing magnesium alloy biomaterial degradability testing device of claim 5, further comprising a control system and a terminal display device, wherein the industrial high-speed camera is connected with the terminal display device through the control system, and the alarm is connected with the control system.
7. The 3D printing device for testing the degradability of the magnesium alloy biomaterial according to claim 1 or 2, wherein the tail end of the sample carrier is of an arc-shaped hand grip structure, and an insulating layer is coated on the outer layer of the hand grip structure.
8. The application of the 3D printing magnesium alloy biomaterial degradability test device according to any one of claims 1-7 on biomedical magnesium alloy comprises the following steps:
(1) simulating the stress condition and the degradation rate of the implanted magnesium alloy by using ansys simulation software, optimizing the structure and the components of the implanted magnesium alloy, and then printing and forming the biological magnesium alloy by using a 3D printing device to obtain a sample;
(2) fixing a sample on a sample carrier, starting a speed regulating motor, driving the sample carrier to move to an ultrasonic device by the speed regulating motor, ultrasonically cleaning for 5-10min, continuously driving the sample carrier to move to a drying device by the speed regulating motor, drying for 4-7min, continuously driving the sample carrier to move to a high-precision balance by the speed regulating motor, and finishing initial weighing of the sample;
(3) adding a simulated blood solution into a liquid storage tank, starting a temperature control system, and heating to 37 +/-0.5 ℃ at a heating rate of 2-10 ℃/min; regulating the pH value of the simulated blood to 7.4 +/-0.05 by using a pH automatic control system, starting a power pump fixed in a liquid storage tank, and controlling the outlet flow speed of the simulated blood passing through the power pump and a high-precision flowmeter to be 14 cm/s;
(4) driving the sample carrier to move to the position close to the right of the center of the heart bionic cabin by a speed regulating motor, closing the speed regulating motor, opening a gas storage tank, introducing carbon dioxide gas into the heart bionic cabin, starting a pressure sensor, and adjusting the pressure value of the position of the sample to be 15 kpa;
(5) opening a hydrogen detector and an alarm, adjusting the distance between the camera and the sample, and feeding back picture information shot by the camera to a control system;
(6) after the control system receives the picture information, the corrosion morphology of the alloy surface is obtained through a processing software computer image recognition technology, and the corrosion behavior of the alloy is analyzed;
(7) when the hydrogen value reaches the set value, triggering an alarm, restarting a speed regulating motor, carrying out ultrasonic treatment, drying and weighing treatment, calculating the weight loss rate, importing the weight loss rate data obtained by calculation into a control system, and comprehensively analyzing the degradability of the alloy by combining the surface corrosion morphology of the alloy.
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