CN108587865A - A kind of magnetic bionanoparticles method extraction serum-virus nucleic acid reagent box - Google Patents
A kind of magnetic bionanoparticles method extraction serum-virus nucleic acid reagent box Download PDFInfo
- Publication number
- CN108587865A CN108587865A CN201810466291.1A CN201810466291A CN108587865A CN 108587865 A CN108587865 A CN 108587865A CN 201810466291 A CN201810466291 A CN 201810466291A CN 108587865 A CN108587865 A CN 108587865A
- Authority
- CN
- China
- Prior art keywords
- fixedly connected
- cylinder
- box body
- wall
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a kind of magnetic bionanoparticles methods to extract serum-virus nucleic acid reagent box, including box body, the upper end of the box body is hinged with box cover, and magnetic means can be magnet or magnetisable material, it can be used to adsorb magnetic bead, the extraction efficiency of serum-virus nucleic acid is effectively improved；When instrument cases need to take out, steel wire is pullled manually, you can easily instrument cases are taken out, can facilitate taking-up classes of agents bottle after taking out instrument cases；Utilize lifting assembly, by connecting external power supply, start motor, motor band moving cam rotates, the effect of reagent bottle fixing device is the placement for facilitating people to stablize and taking and placing classes of agents bottle, save the time, the second cylinder of manual-up promotion, second piston is moved down with respect to the second cylinder, to the movement for making multiple third pistons be located remotely from each other, the movement that multiple clamping plates are located remotely from each other, and then classes of agents bottle can easily be taken out, the taking and placing for conveniently realizing classes of agents bottle, improve test efficiency.
Description
Technical field
The present invention relates to biotechnology, specially a kind of magnetic bionanoparticles method extracts serum-virus nucleic acid reagent
Box.
Background technology
In recent years, with the fast development of biotechnology, functional magnetic bead is gradually applied to using more and more extensive
The isolation and purification of a variety of biological substances such as nucleic acid (RNA and DNA).Compared with the non magnetic method of tradition, step is simple, without
Centrifugation, it is possible to reduce human error.In addition, the research hotspot as nucleic acid extraction medium, paramagnetic particle method also has high sensitivity, fast
The advantages that speed and repeatability.In view of controllability of the magnetic bead under electromagnetic field, have in high flux screening platform extensive
Application prospect.In addition, matching used semi-automatic nucleic acid purifier keeps extraction step easier and quick, also make its popularization
Get up to be more prone to.
Although paramagnetic particle method extracts nucleic acid there is important medical application to be worth, the stability of RNA nucleic acid is less than DNA,
This causes extraction RNA more complicated than extraction DNA.In addition, there are reagent bottles to place shakiness for available reagent box, lead to test efficiency
Lowly.Therefore, the kit of extraction RNA still has much room for improvement in terms of simple operation and improved efficiency in the prior art.
Invention content
The purpose of the present invention is to provide a kind of magnetic bionanoparticles methods to extract serum-virus nucleic acid reagent box, in solution
State the problem of being proposed in background technology.
To achieve the above object, the present invention provides the following technical solutions：
A kind of magnetic bionanoparticles method extraction serum-virus nucleic acid reagent box, including box body, the upper end of the box body are hinged
There is box cover, fixed plate is fixedly connected in the box body, the top of the fixed plate is reagent chamber, and the lower part of fixed plate is to accommodate
Chamber is plugged with pumping case in the accommodating chamber, magnetic means is placed in the pumping case, the upper surface of the fixed plate is placed with down
The upper surface of the installation bucket of end opening, the fixed plate is placed with several ice bags, and the top plate of the installation bucket offers several lead to
The side wall in hole, the box body offers mounting hole, and the side walls hinged of mounting hole has hub cap, the madial wall of the box body to be fixedly connected
There are several snap-gauges, the side wall of the snap-gauge to offer the first groove, the side wall of the first groove is connected with kelly by third spring,
The upper inner wall of the instrument cases offers card slot corresponding with kelly, and the kelly is located at the connection of one end in the first groove
One end of steel wire, the other end of steel wire reach the outside of box body through the side wall of the first groove, box body；
Slide bar is equipped with by lifting assembly in the box body, mounting plate is fixedly connected on the upside of the slide bar, is installed
It is fixedly connected with several reagent bottle fixing devices on the upside of plate, is plugged with respectively in multiple reagent bottle fixing devices for containing
Put the first reagent bottle of the magnetic bionanoparticles reagent of freeze-drying, the second reagent bottle for holding freeze-dried reagent dilution buffer,
For holding the third reagent bottle of serum lysis buffer, the 4th reagent bottle for holding RNA nucleic acid extraction Contrast agents, using
In holding the 5th reagent bottle of washing buffer I, the 6th reagent bottle for holding washing buffer II and for holding
7th reagent bottle of Dnase/Rnase-Free elution buffers.
Preferably, the lifting assembly includes the first cylinder, and the first cylinder is fixedly connected with the lateral wall of box body, and described the
The inner wall of one cylinder slidably connects first piston, and the lower face of first piston is fixedly connected with mounting blocks, the downside of mounting blocks
It is connected in the inner bottom wall of the first cylinder by several first springs, the inner wall of first cylinder is fixedly connected with motor, electricity
The output end of machine is fixedly connected on the rear side of cam, and the cam is flexibly connected with mounting blocks, and first cylinder passes through pipeline
There are two air bag, pipeline fixes the side wall through box body for perforation connection, and the madial wall of the box body symmetrically opens up that there are two bar shapeds
Sliding slot, the side wall of bar shaped sliding slot are fixedly connected with the lower end of air bag, and the upper end of the air bag is fixedly connected on the downside of slide bar, institute
It states and is connected by second spring between the inner roof wall of air bag and inner bottom wall, slide bar is slidably connected with bar shaped sliding slot, the slide bar
Instruction device is installed jointly, the motor and external power supply form a series circuit on left end and box body.
Preferably, the reagent bottle fixing device is the barrel-like structure of upper opening, and the side wall of reagent bottle fixing device is opened
Equipped with several second grooves, the second cylinder is plugged in the second groove, vertical one section of the inner wall of the second cylinder slidably connects
Two pistons, second piston are fixedly connected with one end of the first inserted link, and the other end sliding of the first inserted link through the second cylinder and is consolidated
Surely it is connected on the bottom wall of the second groove, the 5th spring is socketed on first inserted link, the both ends of the 5th spring are separately connected
On the lateral wall of the second cylinder and the bottom wall of the second groove, the inner wall of one section of the second cylinder level slidably connects third
Piston, the side of third piston are fixedly connected with one end of the second inserted link, and the other end sliding of the second inserted link is arrived through the second cylinder
Up to the outside of the second cylinder and it is fixedly connected with clamping plate.
Preferably, movable sleeve is connected to the 6th spring on second inserted link, and the both ends of the 6th spring are connected to third
On the madial wall of the side wall of piston and the second cylinder.
Preferably, the madial wall of the box body is fixedly connected with the gag lever post stablized conducive to sliding bar, and gag lever post sliding is passed through
Wear slide bar.
Preferably, the instruction device includes the first conducting block, and two are offered on the side wall of corresponding bar shaped sliding slot
The side wall of a third groove, third groove is connected with the second conducting block, the second conducting block and the first conducting block by the 4th spring
Flexible connection, the lateral wall of the box body are fixedly connected with corresponding two indicator lights.
Preferably, it is fixedly connected in the fixed plate and is conducive to install the annular rubber ring pad that bucket places stabilization.
Preferably, the gag lever post is L-type structure.
Compared with prior art, the beneficial effects of the invention are as follows：
First, magnetic means can be that magnet or magnetisable material effectively improve serum-virus it can be used to adsorb magnetic bead
The extraction efficiency of nucleic acid；
Second, it installs and offers several through-holes on bucket, by placing multiple ice bags, the cold air in ice bag can pass through through-hole
It is distributed into reagent chamber, suitable environment is provided for the preservation of reagent；
Third, instrument cases take such overlapping mode, placement stabilization and the taking and placing of instrument cases are ensure that, when instrument cases need
When taking out, steel wire is pullled manually, kelly is made to be detached from card slot, you can is easily taken out instrument cases, after taking out instrument cases
Facilitate and takes out classes of agents bottle；
4th, start motor, motor band moving cam rotates, to make peace by connecting external power supply using lifting assembly
Dress block and first piston move down, and then make what slide bar stablized in bar shaped sliding slot to move up, to allow classes of agents bottle
It moves up, realize the promotion of reagent bottle fixing device and falls, effectively conveniently take, put classes of agents bottle, improve experiment
Efficiency；
5th, the effect of instruction device, be easy for people control motor the startup time, when slide bar be moved down into it is minimum
When point, the first conducting block and the contact of underlying second conducting block have connected a circuits, corresponding underlying indicator light
It lights, when slide bar is moved upwards up to peak, b electricity has been connected in the first conducting block and the second conducting block contact being located above
Road, the indicator light being located above accordingly light, and the time for starting motor is controlled convenient for people, time saving and energy saving；
6th, the effect of reagent bottle fixing device is the placement for facilitating people to stablize and taking and placing classes of agents bottle, when saving
Between, the second cylinder of manual-up promotion, second piston is moved down with respect to the second cylinder, to keep multiple third pistons mutually remote
From movement, the movement that multiple clamping plates are located remotely from each other, and then can easily take out classes of agents bottle conveniently realizes
The taking and placing of classes of agents bottle, improve test efficiency.
Description of the drawings
Fig. 1 is schematic structural view of the invention；
Fig. 2 is the portions A structure enlargement diagram；
Fig. 3 is the structural schematic diagram of reagent bottle fixing device；
Fig. 4 is the circuit connection diagram of instruction device.
In figure：Box body 1, pumping case 2, magnetic means 3, ice bag 4, installation bucket 5, rubber ring pad 6, hub cap 7, the first cylinder 8, the
One piston 9, mounting blocks 10, the first spring 11, cam 12, slide bar 13, air bag 14, the first conducting block 15, second spring 16, installation
Plate 17, reagent bottle fixing device 18, gag lever post 19, instrument cases 20, box cover 21, snap-gauge 22, kelly 23, third spring 24, steel wire
25, the second conducting block 26, the 4th spring 27, indicator light 28, the second cylinder 29, second piston 30, the first inserted link 31, the 5th spring
32, third piston 33, the 6th spring 34, the second inserted link 35, clamping plate 36, the first reagent bottle 37, the second reagent bottle 38, third reagent
The 39, the 4th reagent bottle 40 of bottle, the 5th reagent bottle 41, the 6th reagent bottle 42, the 7th reagent bottle 43, fixed plate 44.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
- 4 are please referred to Fig.1, the present invention provides a kind of technical solution：
A kind of magnetic bionanoparticles method extraction serum-virus nucleic acid reagent box, including box body 1, the upper end of box body 1 are hinged with
Box cover 21 is fixedly connected with fixed plate 44 in box body 1, and the top of fixed plate 44 is reagent chamber, and the lower part of fixed plate 44 is to accommodate
Chamber is plugged with pumping case 2 in accommodating chamber, magnetic means 3 is placed in pumping case 2, the upper surface of fixed plate 44 is placed with lower ending opening
Installation bucket 5, the upper surface of fixed plate 44 is placed with several ice bags 4, and the top plate of installation bucket 5 offers several through-holes, box body 1
Side wall offers mounting hole, and the side walls hinged of mounting hole has hub cap 7, the madial wall of box body 1 to be fixedly connected with several snap-gauges 22, card
The side wall of plate 22 offers the first groove, and the side wall of the first groove is connected with kelly 23 by third spring 24, instrument cases 20
Upper inner wall offers card slot corresponding with kelly 23, and kelly 23 is located at the one of the connection of one end in the first groove steel wire 25
End, the other end of steel wire 25 reach the outside of box body 1 through the side wall of the first groove, box body 1；
Slide bar 13 is equipped with by lifting assembly in box body 1, the upside of slide bar 13 is fixedly connected with mounting plate 17, mounting plate
17 upside is fixedly connected with several reagent bottle fixing devices 18, is plugged with respectively in multiple reagent bottle fixing devices 18 for containing
The first reagent bottle 37, the second reagent bottle for holding freeze-dried reagent dilution buffer for putting the magnetic bionanoparticles reagent of freeze-drying
38, the third reagent bottle 39 for holding serum lysis buffer, the 4th reagent for holding RNA nucleic acid extraction Contrast agents
Bottle 40, the 5th reagent bottle 41 for holding washing buffer I, the 6th reagent bottle 42 for holding washing buffer II and use
In the 7th reagent bottle 43 for holding Dnase/Rnase-Free elution buffers, lifting assembly includes the first cylinder 8, the first cylinder
8 are fixedly connected with the lateral wall of box body 1, and the inner wall of the first cylinder 8 slidably connects first piston 9, the lower face of first piston 9
Mounting blocks 10 are fixedly connected with, the downside of mounting blocks 10 is connected to by several first springs 11 in the inner bottom wall of first cylinder 8,
The inner wall of first cylinder 8 is fixedly connected with motor, and the output end of motor is fixedly connected on the rear side of cam 12, cam 12 and installation
Block 10 is flexibly connected, and for the first cylinder 8 by pipeline perforation connection there are two air bag 14, pipeline fixes the side wall through box body 1, box
The madial wall of body 1 is symmetrically opened up there are two bar shaped sliding slot, and the side wall of bar shaped sliding slot is fixedly connected with the lower end of air bag 14, air bag 14
Upper end be fixedly connected on the downside of slide bar 13, connected by second spring 16 between the inner roof wall and inner bottom wall of air bag 14, it is sliding
Bar 13 is slidably connected with bar shaped sliding slot, and instruction device, motor and external power supply are equipped with jointly on the left end and box body 1 of slide bar 13
A series circuit is formed, reagent bottle fixing device 18 is the barrel-like structure of upper opening, the side wall of reagent bottle fixing device 18
Several second grooves are offered, the second cylinder 29 is plugged in the second groove, 29 vertical one section of the inner wall sliding of the second cylinder connects
It is connected to second piston 30, second piston 30 is fixedly connected with one end of the first inserted link 31, and the other end sliding of the first inserted link 31 runs through
It second cylinder 29 and is fixedly connected on the bottom wall of the second groove, the 5th spring 32, the 5th bullet is socketed on the first inserted link 31
The both ends of spring 32 are connected on the lateral wall of the second cylinder 29 and the bottom wall of the second groove, one section of 29 level of the second cylinder
Inner wall slidably connects third piston 33, and the side of third piston 33 is fixedly connected with one end of the second inserted link 35, the second inserted link 35
The other end sliding through the second cylinder 29 reach the second cylinder 29 outside and be fixedly connected with clamping plate 36, the second inserted link 35
Upper movable sleeve is connected to the 6th spring 34, and the both ends of the 6th spring 34 are connected to the side wall and the second cylinder 29 of third piston 33
Madial wall on, the madial wall of box body 1 is fixedly connected conducive to the gag lever post 19 of 13 sliding stability of slide bar, and the sliding of gag lever post 19 runs through
Slide bar 13, instruction device include the first conducting block 15, are opened up on the side wall of corresponding bar shaped sliding slot there are two third groove,
The side wall of third groove is connected with the second conducting block 26,15 activity of the second conducting block 26 and the first conducting block by the 4th spring 27
Connection, the lateral wall of box body 1 are fixedly connected with corresponding two indicator lights 28, are fixedly connected in fixed plate 44 and are conducive to install bucket
5 place stable annular rubber ring pad 6, and gag lever post 19 is L-type structure.
Operation principle：
First, magnetic means 3 can be that magnet or magnetisable material effectively improve serum sickness it can be used to adsorb magnetic bead
The extraction efficiency of malicious nucleic acid；
Second, it installs and offers several through-holes on bucket 5, by placing multiple ice bags 4, the cold air in ice bag 4 can pass through
Through-hole is distributed into reagent chamber, and suitable environment is provided for the preservation of reagent；
Third, instrument cases 20 take such overlapping mode, ensure that placement stabilization and the taking and placing of instrument cases 20, work as tool
When box 20 needs to take out, steel wire 25 is pullled manually, kelly 23 is made to be detached from card slot, you can easily instrument cases 20 are taken out, are taken out
It can facilitate after instrument cases 20 and take out classes of agents bottle；
4th, start motor, motor band moving cam 12 rotates, to make by connecting external power supply using lifting assembly
Mounting blocks 10 and first piston 9 move down, and then make slide bar 13 is stable in bar shaped sliding slot to move up, all kinds of to allow
Reagent bottle moves up, and realizes the promotion of reagent bottle fixing device 18 and falls, and effectively conveniently takes, puts classes of agents bottle, carries
High test efficiency；
5th, the effect of instruction device is easy for the startup time that people control motor, when slide bar 13 is moved down into most
When low spot, a circuits have been connected in the first conducting block 15 and the contact of underlying second conducting block 26, corresponding underlying
Indicator light 28 lights, and when slide bar 13 is moved upwards up to peak, first conducting block 15 and the second conducting block 26 for being located above
Contact, has connected b circuits, and the indicator light 28 being located above accordingly lights, and the time for starting motor is controlled convenient for people, time saving
It is laborsaving；
6th, the effect of reagent bottle fixing device 18 is the placement for facilitating people to stablize and taking and placing classes of agents bottle, is saved
Time, the second cylinder 29 of manual-up promotion, second piston 30 are moved down with respect to the second cylinder 29, to make multiple thirds live
The movement that plug 33 is located remotely from each other, the movement that multiple clamping plates 36 are located remotely from each other, and then classes of agents bottle can easily be taken out, side
Just the taking and placing for efficiently realizing classes of agents bottle, improve test efficiency.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (8)
1. a kind of magnetic bionanoparticles method extracts serum-virus nucleic acid reagent box, including box body (1), it is characterised in that：The box
The upper end of body (1) is hinged with box cover (21), and fixed plate (44) is fixedly connected in the box body (1), the fixed plate (44)
Top is reagent chamber, and the lower part of fixed plate (44) is accommodating chamber, and pumping case (2) is plugged in the accommodating chamber, and the pumping case (2) is interior
It is placed with magnetic means (3), the upper surface of the fixed plate (44) is placed with the installation bucket (5) of lower ending opening, the fixed plate
(44) upper surface is placed with several ice bags (4), and the top plate of the installation bucket (5) offers several through-holes, the box body (1)
Side wall offers mounting hole, and the side walls hinged of mounting hole has a hub cap (7), and the madial wall of the box body (1) is fixedly connected with several
The side wall of snap-gauge (22), the snap-gauge (22) offers the first groove, and the side wall of the first groove is connected by third spring (24)
There are kelly (23), the upper inner wall of the instrument cases (20) to offer card slot corresponding with kelly (23), the kelly (23)
One end of one end connection steel wire (25) in the first groove, the other end of steel wire (25) is through the first groove, box body (1)
Side wall reaches the outside of box body (1)；
Slide bar (13) is equipped with by lifting assembly in the box body (1), installation is fixedly connected on the upside of the slide bar (13)
Plate (17), several reagent bottle fixing devices (18) are fixedly connected on the upside of mounting plate (17), and multiple reagent bottles fix dress
It sets and is plugged with the first reagent bottle (37) of the magnetic bionanoparticles reagent for holding freeze-drying on (18) respectively, for holding freeze-drying
The second reagent bottle (38) of reagent dilutions buffer solution, the third reagent bottle (39) for holding serum lysis buffer, for containing
It puts the 4th reagent bottle (40) of RNA nucleic acid extraction Contrast agents, the 5th reagent bottle (41) for holding washing buffer I, use
In the 6th reagent bottle (42) for holding washing buffer II and for holding Dnase/Rnase-Free elution buffers the 7th
Reagent bottle (43).
2. a kind of magnetic bionanoparticles method according to claim 1 extracts serum-virus nucleic acid reagent box, it is characterised in that：
The lifting assembly includes the first cylinder (8), and the first cylinder (8) is fixedly connected with the lateral wall of box body (1), first cylinder
(8) inner wall slidably connects first piston (9), and the lower face of first piston (9) is fixedly connected with mounting blocks (10), mounting blocks
(10) downside is connected to by several first springs (11) in the inner bottom wall of the first cylinder (8), first cylinder (8) it is interior
Wall is fixedly connected with motor, and the output end of motor is fixedly connected on the rear side of cam (12), the cam (12) and mounting blocks
(10) it is flexibly connected, for first cylinder (8) by pipeline perforation connection there are two air bag (14), pipeline, which is fixed, runs through box body
(1) side wall, the madial wall of the box body (1) symmetrically open up that there are two bar shaped sliding slot, side wall and the air bags (14) of bar shaped sliding slot
Lower end be fixedly connected, the upper end of the air bag (14) is fixedly connected on the downside of slide bar (13), the interior top of the air bag (14)
It is connected by second spring (16) between wall and inner bottom wall, slide bar (13) is slidably connected with bar shaped sliding slot, the slide bar (13)
Instruction device is installed jointly, the motor and external power supply form a series circuit on left end and box body (1).
3. a kind of magnetic bionanoparticles method according to claim 1 extracts serum-virus nucleic acid reagent box, it is characterised in that：
The reagent bottle fixing device (18) is the barrel-like structure of upper opening, and the side wall of reagent bottle fixing device (18) offers several
Second groove is plugged with the second cylinder (29) in the second groove, and vertical one section of the inner wall of the second cylinder (29) slidably connects
Two pistons (30), second piston (30) are fixedly connected with one end of the first inserted link (31), and the other end sliding of the first inserted link (31) is passed through
It wears the second cylinder (29) and is fixedly connected on the bottom wall of the second groove, the 5th spring is socketed on first inserted link (31)
(32), the both ends of the 5th spring (32) are connected on the lateral wall of the second cylinder (29) and the bottom wall of the second groove, described
The inner wall of one section of the second cylinder (29) level slidably connects third piston (33), and the side of third piston (33) is fixedly connected with
The other end sliding of one end of two inserted links (35), the second inserted link (35) reaches the outer of the second cylinder (29) through the second cylinder (29)
Portion and it is fixedly connected with clamping plate (36).
4. extracting serum-virus nucleic acid reagent box according to a kind of magnetic bionanoparticles method that claim 3 is stated, it is characterised in that：Institute
It states movable sleeve on the second inserted link (35) and is connected to the 6th spring (34), the both ends of the 6th spring (34) are connected to third piston
(33) on the madial wall of side wall and the second cylinder (29).
5. a kind of magnetic bionanoparticles method according to claim 2 extracts serum-virus nucleic acid reagent box, it is characterised in that：
The madial wall of the box body (1) is fixedly connected conducive to the gag lever post (19) of slide bar (13) sliding stability, and gag lever post (19) sliding is passed through
Wear slide bar (13).
6. a kind of magnetic bionanoparticles method according to claim 2 extracts serum-virus nucleic acid reagent box, it is characterised in that：
The instruction device includes the first conducting block (15), is opened up on the side wall of corresponding bar shaped sliding slot there are two third groove,
The side wall of third groove is connected with the second conducting block (26), the second conducting block (26) and the first conducting block by the 4th spring (27)
(15) it is flexibly connected, the lateral wall of the box body (1) is fixedly connected with corresponding two indicator lights (28).
7. a kind of magnetic bionanoparticles method according to claim 1 extracts serum-virus nucleic acid reagent box, it is characterised in that：
It is fixedly connected on the fixed plate (44) and is conducive to install the annular rubber ring pad (6) that bucket (5) places stabilization.
8. a kind of magnetic bionanoparticles method according to claim 5 extracts serum-virus nucleic acid reagent box, it is characterised in that：
The gag lever post (19) is L-type structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810466291.1A CN108587865A (en) | 2018-05-16 | 2018-05-16 | A kind of magnetic bionanoparticles method extraction serum-virus nucleic acid reagent box |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810466291.1A CN108587865A (en) | 2018-05-16 | 2018-05-16 | A kind of magnetic bionanoparticles method extraction serum-virus nucleic acid reagent box |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108587865A true CN108587865A (en) | 2018-09-28 |
Family
ID=63631211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810466291.1A Pending CN108587865A (en) | 2018-05-16 | 2018-05-16 | A kind of magnetic bionanoparticles method extraction serum-virus nucleic acid reagent box |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108587865A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109777723A (en) * | 2019-04-04 | 2019-05-21 | 曹怡珺 | A kind of magnetic bionanoparticles method extraction serum-virus nucleic acid reagent box |
| CN111514945A (en) * | 2020-05-13 | 2020-08-11 | 淄博市中心医院 | Biomarker of tumor, application and tumor detection kit |
| CN112023819A (en) * | 2020-08-31 | 2020-12-04 | 刘根 | Liquid mixing arrangement that gets of chemical production usefulness |
| CN113082461A (en) * | 2021-04-14 | 2021-07-09 | 梁大梅 | Medical pipeline fixing device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN206089658U (en) * | 2016-10-13 | 2017-04-12 | 北京国科融智生物技术有限公司 | Biological nanometer paramagnetic particle method extracts serum virus DNA kit |
| CN206089660U (en) * | 2016-10-13 | 2017-04-12 | 北京国科融智生物技术有限公司 | Biological nanometer paramagnetic particle method draws viral RNA kit |
| CN206089659U (en) * | 2016-10-13 | 2017-04-12 | 北京国科融智生物技术有限公司 | Biological nanometer paramagnetic particle method draws viral DNA kit |
-
2018
- 2018-05-16 CN CN201810466291.1A patent/CN108587865A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN206089658U (en) * | 2016-10-13 | 2017-04-12 | 北京国科融智生物技术有限公司 | Biological nanometer paramagnetic particle method extracts serum virus DNA kit |
| CN206089660U (en) * | 2016-10-13 | 2017-04-12 | 北京国科融智生物技术有限公司 | Biological nanometer paramagnetic particle method draws viral RNA kit |
| CN206089659U (en) * | 2016-10-13 | 2017-04-12 | 北京国科融智生物技术有限公司 | Biological nanometer paramagnetic particle method draws viral DNA kit |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109777723A (en) * | 2019-04-04 | 2019-05-21 | 曹怡珺 | A kind of magnetic bionanoparticles method extraction serum-virus nucleic acid reagent box |
| CN111514945A (en) * | 2020-05-13 | 2020-08-11 | 淄博市中心医院 | Biomarker of tumor, application and tumor detection kit |
| CN111514945B (en) * | 2020-05-13 | 2022-06-21 | 淄博市中心医院 | Tumor detection kit containing tumor biomarkers |
| CN112023819A (en) * | 2020-08-31 | 2020-12-04 | 刘根 | Liquid mixing arrangement that gets of chemical production usefulness |
| CN113082461A (en) * | 2021-04-14 | 2021-07-09 | 梁大梅 | Medical pipeline fixing device |
| CN113082461B (en) * | 2021-04-14 | 2022-09-02 | 梁大梅 | Medical pipeline fixing device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108587865A (en) | A kind of magnetic bionanoparticles method extraction serum-virus nucleic acid reagent box | |
| CN206089659U (en) | Biological nanometer paramagnetic particle method draws viral DNA kit | |
| CN201961948U (en) | Permanent magnetic lifter | |
| CN108974577A (en) | A kind of box of slow virus kit | |
| CN206862697U (en) | Sealed electromagnetic formula sampler is used in a kind of soy sauce processing | |
| CN104263633A (en) | Magnetic-separation-based high-flux biological sample treatment device | |
| CN209606575U (en) | A kind of turnover mechanism of chip testing machine | |
| CN208717331U (en) | Magnetic pipettor | |
| CN208791661U (en) | A kind of paramagnetic particle method nucleic acid magnetic frame | |
| CN208588832U (en) | Device for hydrogeologic prospecting | |
| CN106586899A (en) | Heavy object storage device | |
| CN209387380U (en) | A kind of magnetic separating device and device for analyzing samples | |
| CN207623112U (en) | A kind of stirring sampling apparatus of Urine Analyzer | |
| CN206089658U (en) | Biological nanometer paramagnetic particle method extracts serum virus DNA kit | |
| CN214585467U (en) | Full-automatic high flux immunomagnetic bead separator | |
| CN206219032U (en) | A kind of permanent magnet hanger | |
| CN204910865U (en) | Novel solid -phase extraction system | |
| CN208661042U (en) | A kind of biologic test reagent extraction element | |
| CN206857410U (en) | A kind of soy sauce storage tank of achievable multidigit section sampling | |
| CN113533705A (en) | Early detection reagent for diabetic nephropathy based on biomarkers | |
| CN208805337U (en) | A kind of tool for testing mobile phone | |
| CN106348148A (en) | Permanently magnetic lifting appliance | |
| CN206089660U (en) | Biological nanometer paramagnetic particle method draws viral RNA kit | |
| CN208131246U (en) | The metal of rare earth permanent-magnetic material sorts recyclable device | |
| CN212206808U (en) | Sample extraction element for it is biological experiments |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180928 |
|
| RJ01 | Rejection of invention patent application after publication |