CN108567125A - The soft capsule and preparation method prepared with wolfberry fruit extract with royal jelly or propolis - Google Patents
The soft capsule and preparation method prepared with wolfberry fruit extract with royal jelly or propolis Download PDFInfo
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- CN108567125A CN108567125A CN201710145460.7A CN201710145460A CN108567125A CN 108567125 A CN108567125 A CN 108567125A CN 201710145460 A CN201710145460 A CN 201710145460A CN 108567125 A CN108567125 A CN 108567125A
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- fruit extract
- royal jelly
- wolfberry fruit
- propolis
- soft capsule
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- 244000241838 Lycium barbarum Species 0.000 title claims abstract description 172
- 235000015459 Lycium barbarum Nutrition 0.000 title claims abstract description 172
- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 123
- 229940109850 royal jelly Drugs 0.000 title claims abstract description 123
- 235000015468 Lycium chinense Nutrition 0.000 title claims abstract description 122
- 241000241413 Propolis Species 0.000 title claims abstract description 73
- 229940069949 propolis Drugs 0.000 title claims abstract description 73
- 239000007901 soft capsule Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 238000002156 mixing Methods 0.000 claims abstract description 43
- 238000000034 method Methods 0.000 claims abstract description 24
- 239000012535 impurity Substances 0.000 claims abstract description 19
- 230000008569 process Effects 0.000 claims abstract description 15
- 239000000654 additive Substances 0.000 claims abstract description 13
- 230000000996 additive effect Effects 0.000 claims abstract description 13
- 238000004806 packaging method and process Methods 0.000 claims abstract description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 22
- 230000003213 activating effect Effects 0.000 claims description 16
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- 229920001778 nylon Polymers 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 238000004108 freeze drying Methods 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 8
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 239000003708 ampul Substances 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 4
- 235000012680 lutein Nutrition 0.000 claims description 4
- 229960005375 lutein Drugs 0.000 claims description 4
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims description 4
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- 239000001656 lutein Substances 0.000 claims description 4
- 229920001282 polysaccharide Polymers 0.000 claims description 4
- 239000005017 polysaccharide Substances 0.000 claims description 4
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims description 4
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- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Jellies, Jams, And Syrups (AREA)
Abstract
The invention belongs to medicines and health protection technical fields, and in particular to the soft capsule and preparation method prepared with wolfberry fruit extract with royal jelly or propolis.The invention discloses the soft capsules prepared with wolfberry fruit extract with royal jelly or propolis, and the soft capsule includes royal jelly or propolis wolfberry fruit extract includes：85%~90% royal jelly or propolis, 9%~14% wolfberry fruit extract and 1%~3% additive.Also disclose the preparation method of the royal jelly or propolis wolfberry fruit extract soft capsule, including the processes such as removal of impurities, charging, preliminary mixing, secondary mixing, vacuum dehydrating at lower temperature, packaging.The present invention provides the soft capsule prepared with wolfberry fruit extract with royal jelly or propolis and preparation methods, matrimony vine bee product is set to be integrated with enhancing possessed by anti-oxidant, anti-aging, hypoglycemic, reducing blood lipid and matrimony vine possessed by royal jelly or propolis immune and other effects, the perfect adaptation for realizing matrimony vine and bee product makes the nutrition of matrimony vine bee product, color and luster, mouthfeel, physical and chemical index obtain keeping to greatest extent.
Description
Technical field
The invention belongs to medicines and health protection technical fields, and in particular to be prepared with wolfberry fruit extract with royal jelly or propolis soft
Capsule and preparation method.
Background technology
Although China is the first in the world bee-keeping big country, but be not bee-keeping power.It quickly rises abruptly with developed country and some apicultures
The country risen compares, and there are still certain poor in production, processing, scientific research of bee raising and honey etc. for China's bee industry
Away from.In recent years 2000 beautiful yuan/ton or so, more beautiful than world honey export market price 2000-3000 yuan/ton of China's honey outlet average price
It is low.At a low price so that China's honey becomes the target of external trade barrier, the anti-dumping in the U.S., European Union's green barrier, Japan repeatedly
The limitation that positive list etc. exports China's bee product so that the road of bee product outlet is extremely difficult.
Ningxia is the authentic source area of matrimony vine, and matrimony vine is unique genuine precious Chinese herbal medicine named with Ningxia zone name,
China and foreign countries are enjoyed great prestige from ancient times, and there is very high pharmaceutical value and healthcare function.In recent years, under the support of industrial policy, whole district matrimony vine
Cultivated area constantly expands, and quality is promoted steadily, and sales volume and the output value are significantly increased.But there is also producing region resources advantages simultaneously not
The problems such as enough apparent, excellent rearing new varieties are not rapid enough, brand protection system is incomplete, market circulation network is not well established.
The key of lycium barbarum industry development is the drive of deep processing project and promotes ability.Lycium barbarum industry is due to deep processing item
Mesh development relatively lags behind in base development, there is a problem of that deep processing conversion ratio and appreciation rate are low.Matrimony vine product is mostly with dry fruit
Therefore the terminal consumer goods are limited by market capacity, Sales Channel, bring stability to matrimony vine planting income and increase wind
Dangerous factor influences the coordinated development of industry health.
Invention content
The problem of based on background technology, the present invention provides what is prepared with wolfberry fruit extract with royal jelly or propolis
Soft capsule and preparation method, make matrimony vine bee product be integrated with anti-oxidant, anti-aging possessed by royal jelly or propolis, it is hypoglycemic,
Reducing blood lipid and the possessed enhancing of matrimony vine are immune and other effects, realize the perfect adaptation of matrimony vine and bee product, make matrimony vine bee product
Nutrition, color and luster, mouthfeel, physical and chemical index obtained keeping to greatest extent, health-care efficacy is better than general bee product and matrimony vine product,
Product efficacy differentiation is apparent, and market prospects are very wide.
To realize the above-mentioned technical purpose, the technical solution adopted by the present invention is as follows：
The soft capsule prepared with wolfberry fruit extract with royal jelly or propolis, the soft capsule includes royal jelly or propolis matrimony vine
Extract includes：85%~90% royal jelly or propolis, 9%~14% wolfberry fruit extract and 1%~3% additive.
Preferably, the additive includes wolfberry fruit extract activating agent.Such design, it is ensured that matrimony vine has
Effect activity, can be that matrimony vine plays a significant role.
With the preparation method for the soft capsule that royal jelly or propolis are prepared with wolfberry fruit extract, include the following steps：
Step 1：Removal of impurities；The royal jelly or propolis are melted under the conditions of 50 DEG C~60 DEG C, equivalent is then added
Distilled water stirs evenly, then is filtered with 80~100 mesh nylon gauzes, removes impurity therein；
Step 2：Charging；The wolfberry fruit extract is added in royal jelly or propolis after step 1 removal of impurities；
Step 3：Preliminary mixing；By containing wolfberry fruit extract in step 3 royal jelly or propolis carried out in canister just
Step mixes and additive is added；
Step 4：Secondary mixing；By through tentatively mixing royal jelly or propolis and wolfberry fruit extract input in big tank, carry out
Secondary mixing；
Step 5：Vacuum dehydrating at lower temperature；By the royal jelly containing wolfberry fruit extract of secondary mixing or propolis with 100~
150 mesh nylon gauzes filter, and the filtered royal jelly containing wolfberry fruit extract or propolis are distributed into vacuum freeze drier
Pallet in, the thickness of royal jelly or propolis containing wolfberry fruit extract is 8mm~10mm, or is carried filtered containing matrimony vine
It takes the royal jelly of object or propolis to be packed into the ampulla on ampulla frame, wouldn't seal, it is indoor to put freeze-drying into.Start vacuum refrigeration
The temperature of vacuum drying cabinet is down to -40 DEG C by drying machine, then by vacuum degree control in 10 ± 1mmHg, make it is filtered containing
The royal jelly of wolfberry fruit extract or the temperature of propolis are maintained at -25 ± 2 DEG C, and the temperature of condenser is controlled at -50 ± 2 DEG C, simultaneously
The heating of freeze drying chamber component is given, is transmitted to charging tray, promotes water sublimed, detects the royal jelly containing wolfberry fruit extract or propolis
Moisture is 1.5%~2.5%, that is, drying process is completed, by the royal jelly containing wolfberry fruit extract to dry out or bee
Dry powder is made after rubber pulverizing；
Step 6：Tabletting；By matrimony vine bee product freeze-dried powder made from step 5 through tableting process, it is 300 millis that dosage, which is made,
Gram/piece tablet, releasing agent is added in tablet forming technique；
Step 7：Packaging；Tablet in step 6 is fitted into soft capsule.
Preferably, the wolfberry fruit extract in the step 2 includes polysaccharides, matrimony vine lutein, bata-carotene,
The polysaccharides, matrimony vine lutein, bata-carotene are in micro mist shape, such design, can make the wolfberry fruit extract include
The important active ingredient beneficial to human body in matrimony vine is in micro mist shape, can make to be easier to be uniformly mixed when stirring.
Preferably, incorporation time in the step 3 is 4h~6h, such design can make to stir evenly
In the case of, incorporation time is reduced, working efficiency is increased.
Preferably, mixing speed when being mixed in the step 4 is 40r/min~60r/min, such design,
The mixture of viscosity higher can be enable effectively to mix, and prevent from generating heat in whipping process, make the performance of product by
It influences.
Preferably, wolfberry fruit extract described in the step 3 uses ultrasonic sterilization, such design can be with
The activity of wolfberry fruit extract is set to keep more permanent.
Preferably, the power 250W of the ultrasonic wave, ultrasonic treatment time is 15 ± 2min, such design,
Effectively wolfberry fruit extract can be sterilized.
Preferably, envionmental humidity is less than 60% in the step 7, such design, it is ensured that product exists
When packaging, the influence of moisture in air is reduced.
Preferably, wolfberry fruit extract in the step 2 is filtered with the mesh nylon yarn of 100 mesh~120, it is such to set
Meter, it is ensured that wolfberry fruit extract can be uniformly mixed in mixing below, keep product unaffected.
The method have the benefit that：
1. royal jelly, propolis and the significant lycium barbarum of medical health effect that raw material selects green pure natural, one is clear, and one
It mends, there is benefit, bowl spares to have clearly in clear, clear mend combines, and controls to support and lay equal stress on, is modern high technology technique and motherland's Traditional Chinese Medicine theory
Perfect adaptation；
2. according to formula material chemical composition property, the physical condition of the needs and production of healthcare function and target user
Etc. consider, soft capsule preparation has biological utilisation compared with other the in the market dosage forms such as common tablet, pulvis
The characteristics of spending accurate height, good airproof performance, content, good appearance, not only improves the healthcare function for giving full play to matrimony vine bee product, again
Suitable for industrialized production, simple process, cost are relatively low, and instant edible, and easy to carry, transport, storage can effectively meet applicable
The needs of crowd；
3. have both the unique bioactive substance contained by royal jelly or propolis and matrimony vine, effective integration royal jelly or bee
Enhancing possessed by anti-oxidant possessed by glue, anti-aging, hypoglycemic, reducing blood lipid and matrimony vine is immune and other effects, realizes matrimony vine
With the perfect adaptation of bee product, the nutrition of matrimony vine bee product, color and luster, mouthfeel, physical and chemical index is made to have obtained keeping to greatest extent, protected
Strong effect is better than general bee product and matrimony vine product, and product efficacy differentiation is apparent, and market prospects are very wide.
Description of the drawings
The present invention can be further illustrated by the nonlimiting examples that attached drawing provides；
Fig. 1 is the flow chart of the preparation method for the soft capsule that present invention royal jelly or propolis are prepared with wolfberry fruit extract.
Specific implementation mode
In order to make those skilled in the art that the present invention may be better understood, with reference to the accompanying drawings and examples to this hair
Bright technical solution further illustrates.
The soft capsule of the present invention prepared with wolfberry fruit extract with royal jelly or propolis, component include royal jelly or propolis,
Wolfberry fruit extract, additive, wherein the weight ratio of royal jelly or propolis is：85%~90%, the weight ratio of wolfberry fruit extract
Example be：9%~14%, the weight ratio of additive is：1%~3%, additive includes wolfberry fruit extract activating agent.
It should be pointed out that additive includes wolfberry fruit extract activating agent, such design, it is ensured that matrimony vine it is effective
Activity can be that matrimony vine plays a significant role.In fact, can also consider specific additive types according to actual conditions.
As shown in Figure 1, the preparation method of the soft capsule prepared with wolfberry fruit extract with royal jelly or propolis, can by with
Under several specific embodiments be expanded on further.
Embodiment one
By royal jelly, wolfberry fruit extract, wolfberry fruit extract activating agent according to weight ratio royal jelly：Wolfberry fruit extract：It includes
Wolfberry fruit extract activating agent is：85%：14%：1% is tested；
Step 1：Removal of impurities；The royal jelly is melted under the conditions of 50 DEG C, the distilled water of equivalent, stirring is then added
Uniformly, then with 80 mesh nylon gauzes it filters, removes impurity therein；
Step 2：Charging；The wolfberry fruit extract is passed through into ultrasonic sterilization 15min, then passes through 100 nylon gauzes
Filtering is added in the royal jelly after step 1 removal of impurities；
Step 3：Preliminary mixing；Royal jelly containing wolfberry fruit extract in step 3 is carried out in canister tentatively mixing,
And it is added and includes wolfberry fruit extract activating agent；
Step 4：Secondary mixing；Royal jelly through tentatively mixing is inputted with wolfberry fruit extract in big tank, is carried out secondary mixed
It closes, mixing speed 40r/min；
Step 5：Vacuum dehydrating at lower temperature；By the royal jelly containing wolfberry fruit extract of secondary mixing or propolis with 100 mesh Buddhist nuns
Imperial gauze filtering, the filtered royal jelly containing wolfberry fruit extract is distributed into the pallet of vacuum freeze drier, is contained
The thickness of the royal jelly of wolfberry fruit extract is 8mm, and it is indoor to put freeze-drying into.Vacuum freeze drier is started, will be dried in vacuo
The temperature of room is down to -40 DEG C, then by vacuum degree control in 9mmHg, make the filtered royal jelly containing wolfberry fruit extract or
The temperature of propolis is maintained at -23 DEG C, and the temperature of condenser is controlled at -50 DEG C, while being heated to freeze drying chamber component, and material is transmitted to
Disk promotes water sublimed, and the moisture for detecting the royal jelly containing wolfberry fruit extract or propolis is 1.5%, that is, completes drying
Dry powder is made after crushing the royal jelly containing wolfberry fruit extract or propolis that dry out in process；
Step 6：Tabletting；By matrimony vine bee product freeze-dried powder made from step 5 through tableting process, it is 300 millis that dosage, which is made,
Gram/piece tablet, releasing agent is added in tablet forming technique；
Step 7：Packaging；Tablet in step 6 is fitted into soft capsule, product is obtained.
In this way, in process of production, royal jelly can melt completely at 50 DEG C, and when mixing, product can be uniformly mixed,
Obtained shelf life of products is longer, ensure that the performance of royal jelly and the activity of wolfberry fruit extract.
Embodiment two
By royal jelly, wolfberry fruit extract, wolfberry fruit extract activating agent according to weight ratio royal jelly：Wolfberry fruit extract：It includes
Wolfberry fruit extract activating agent is：90%：9%：1% is tested；
Step 1：Removal of impurities；The royal jelly is melted under the conditions of 60 DEG C, the distilled water of equivalent, stirring is then added
Uniformly, then with 80 mesh nylon gauzes it filters, removes impurity therein；
Step 2：Charging；The wolfberry fruit extract is passed through into ultrasonic sterilization 15min, then passes through 120 nylon gauzes
Filtering is added in the royal jelly after step 1 removal of impurities；
Step 3：Preliminary mixing；Royal jelly containing wolfberry fruit extract in step 3 is carried out in canister tentatively mixing,
And it is added and includes wolfberry fruit extract activating agent；
Step 4：Secondary mixing；Royal jelly through tentatively mixing is inputted with wolfberry fruit extract in big tank, is carried out secondary mixed
It closes, mixing speed 60r/min；
Step 5：Vacuum dehydrating at lower temperature；By the royal jelly containing wolfberry fruit extract of secondary mixing or propolis with 150 mesh Buddhist nuns
Imperial gauze filtering, the filtered royal jelly containing wolfberry fruit extract is distributed into the pallet of vacuum freeze drier, is contained
The thickness of the royal jelly of wolfberry fruit extract is 10mm, and it is indoor to put freeze-drying into.Vacuum freeze drier is started, will be dried in vacuo
The temperature of room is down to -40 DEG C, then by vacuum degree control in 11mmHg, make the filtered royal jelly containing wolfberry fruit extract or
The temperature of propolis is maintained at -27 DEG C, and the temperature of condenser is controlled at -50 DEG C, while being heated to freeze drying chamber component, and material is transmitted to
Disk promotes water sublimed, and the moisture for detecting the royal jelly containing wolfberry fruit extract or propolis is 2.5%, that is, completes drying
Dry powder is made after crushing the royal jelly containing wolfberry fruit extract or propolis that dry out in process；
Step 6：Tabletting；By matrimony vine bee product freeze-dried powder made from step 5 through tableting process, it is 300 millis that dosage, which is made,
Gram/piece tablet, releasing agent is added in tablet forming technique；
Step 7：Packaging；Tablet in step 6 is fitted into soft capsule, product is obtained.
In this way, in process of production, royal jelly can melt completely at 60 DEG C, and will not cause temperature is excessively high to cause
The reduced performance of royal jelly, when mixing, product can be uniformly mixed, and be not in the excessively high reduced performance for leading to product of fever
The problem of, obtained shelf life of products is longer, ensure that the performance of royal jelly and the activity of wolfberry fruit extract.
Embodiment three
By royal jelly, wolfberry fruit extract, wolfberry fruit extract activating agent according to weight ratio royal jelly：Wolfberry fruit extract：It includes
Wolfberry fruit extract activating agent is：85%：12%：3% is tested；
Step 1：Removal of impurities；The royal jelly is melted under the conditions of 55 DEG C, the distilled water of equivalent, stirring is then added
Uniformly, then with 80 mesh nylon gauzes it filters, removes impurity therein；
Step 2：Charging；The wolfberry fruit extract is passed through into ultrasonic sterilization 14min, then passes through 100 nylon gauzes
Filtering is added in the royal jelly after step 1 removal of impurities；
Step 3：Preliminary mixing；Royal jelly containing wolfberry fruit extract in step 3 is carried out in canister tentatively mixing,
And it is added and includes wolfberry fruit extract activating agent；
Step 4：Secondary mixing；Royal jelly through tentatively mixing is inputted with wolfberry fruit extract in big tank, is carried out secondary mixed
It closes, mixing speed 50r/min；
Step 5：Vacuum dehydrating at lower temperature；By the royal jelly containing wolfberry fruit extract of secondary mixing or propolis with 120 mesh Buddhist nuns
Imperial gauze filtering, the filtered royal jelly containing wolfberry fruit extract is distributed into the pallet of vacuum freeze drier, is contained
The thickness of the royal jelly of wolfberry fruit extract is 10mm, and it is indoor to put freeze-drying into.Vacuum freeze drier is started, will be dried in vacuo
The temperature of room is down to -40 DEG C, then by vacuum degree control in 10mmHg, make the filtered royal jelly containing wolfberry fruit extract or
The temperature of propolis is maintained at -25 DEG C, and the temperature of condenser is controlled at -50 DEG C, while being heated to freeze drying chamber component, and material is transmitted to
Disk promotes water sublimed, and the moisture for detecting the royal jelly containing wolfberry fruit extract or propolis is 2%, that is, is completed dried
Dry powder is made after crushing the royal jelly containing wolfberry fruit extract or propolis that dry out in journey；
Step 6：Tabletting；By matrimony vine bee product freeze-dried powder made from step 5 through tableting process, it is 300 millis that dosage, which is made,
Gram/piece tablet, releasing agent is added in tablet forming technique；
Step 7：Packaging；Tablet in step 6 is fitted into soft capsule, product is obtained.
In this way, in process of production, royal jelly can melt completely, and will not cause temperature is excessively high to lead to royal jelly
Reduced performance, when mixing, product can be uniformly mixed, and be not in asking for the excessively high reduced performance for leading to product of fever
Topic, obtained shelf life of products is longer, ensure that the performance of royal jelly and the activity of wolfberry fruit extract.
Example IV
By royal jelly, wolfberry fruit extract, wolfberry fruit extract activating agent according to weight ratio royal jelly：Wolfberry fruit extract：It includes
Wolfberry fruit extract activating agent is：88%：10%：2% is tested；
Step 1：Removal of impurities；The royal jelly is melted under the conditions of 55 DEG C, the distilled water of equivalent, stirring is then added
Uniformly, then with 80 mesh nylon gauzes it filters, removes impurity therein；
Step 2：Charging；The wolfberry fruit extract is passed through into ultrasonic sterilization 14min, then passes through 120 nylon gauzes
Filtering is added in the royal jelly after step 1 removal of impurities；
Step 3：Preliminary mixing；Royal jelly containing wolfberry fruit extract in step 3 is carried out in canister tentatively mixing,
And it is added and includes wolfberry fruit extract activating agent；
Step 4：Secondary mixing；Royal jelly through tentatively mixing is inputted with wolfberry fruit extract in big tank, is carried out secondary mixed
It closes, mixing speed 50r/min；
Step 5：Vacuum dehydrating at lower temperature；By the royal jelly containing wolfberry fruit extract of secondary mixing or propolis with 100 mesh Buddhist nuns
Imperial gauze filtering, the filtered royal jelly containing wolfberry fruit extract is distributed into the pallet of vacuum freeze drier, is contained
The thickness of the royal jelly of wolfberry fruit extract is 10mm, and it is indoor to put freeze-drying into.Vacuum freeze drier is started, will be dried in vacuo
The temperature of room is down to -40 DEG C, then by vacuum degree control in 10mmHg, make the filtered royal jelly containing wolfberry fruit extract or
The temperature of propolis is maintained at -25 DEG C, and the temperature of condenser is controlled at -50 DEG C, while being heated to freeze drying chamber component, and material is transmitted to
Disk promotes water sublimed, and the moisture for detecting the royal jelly containing wolfberry fruit extract or propolis is 2%, that is, is completed dried
Dry powder is made after crushing the royal jelly containing wolfberry fruit extract or propolis that dry out in journey；
Step 6：Tabletting；By matrimony vine bee product freeze-dried powder made from step 5 through tableting process, it is 300 millis that dosage, which is made,
Gram/piece tablet, releasing agent is added in tablet forming technique；
Step 7：Packaging；Tablet in step 6 is fitted into soft capsule, product is obtained.
In this way, in process of production, royal jelly can melt completely, and will not cause temperature is excessively high to lead to royal jelly
Reduced performance, when mixing, product can be uniformly mixed, and be not in asking for the excessively high reduced performance for leading to product of fever
Topic, obtained shelf life of products is longer, ensure that the performance of royal jelly and the activity of wolfberry fruit extract.
By product that embodiment one, two, three, four obtains and royal jelly product and matrimony vine product be distributed to six groups it is different old
People is edible, after a period of time, to old man's body data index with eat before be detected, obtained data are shown in Table one.
Table one
| It is anti-oxidant | Blood glucose | Blood fat | Immunity | |
| Royal jelly product | Increase by 5.1% | Reduce by 10.1% | Reduce by 7.3% | Increase by 13.2% |
| Matrimony vine product | Increase by 3.2% | Reduce by 6.8% | Reduce by 4.9% | Increase by 15.6% |
| Embodiment one | Increase by 5.6% | Reduce by 10.8% | Reduce by 7.8% | Increase by 16.2% |
| Embodiment two | Increase by 6.3% | Reduce by 10.6% | Reduce by 7.6% | Increase by 16.7% |
| Embodiment three | Increase by 6.1% | Reduce by 10.3% | Reduce by 8.0% | Increase by 15.9% |
| Example IV | Increase by 5.9% | Reduce by 11.2% | Reduce by 8.3% | Increase by 16.8% |
It should be pointed out that the content of the ester matter Peroxidation Product malonaldehyde in determination oxidative blood is reflected
It is fixed.
As shown in chart one, for product produced by the present invention relative to royal jelly product, oxidation resistant raising is not apparent
Gap, but all improve, relative to matrimony vine product, there is larger promotion, and blood glucose, blood fat are produced relative to royal jelly
Product decrease, and have apparent reduction, while also increased immunity relative to matrimony vine product, and pass through the anti-of the old men
Feedback, product of the invention is relatively preferable relative to general royal jelly product and matrimony vine product color, keeps the appetite of people preferable, and
And its mouthfeel is also superior to general royal jelly product and matrimony vine product, and product of the present invention is eaten, the spiritual gas of old man is preferable, has
The effect of delaying senility.
It should be pointed out that the product obtained with propolis and matrimony vine, can also obtain producing better than general propolis product and matrimony vine
Product.
Above-described embodiment is merely exemplary to illustrate the principle of the present invention and its effect, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology can all carry out modifications and changes to above-described embodiment without violating the spirit and scope of the present invention.Cause
This, all those of ordinary skill in the art are completed without departing from the spirit and technical ideas disclosed in the present invention
All equivalent modifications or change, should by the present invention claim be covered.
Claims (10)
1. the soft capsule prepared with wolfberry fruit extract with royal jelly or propolis, it is characterised in that：Component include royal jelly or propolis,
The weight ratio of wolfberry fruit extract, additive, the royal jelly or propolis is：85%~90%, the weight of the wolfberry fruit extract
Amount ratio is：9%~14%, the weight ratio of the additive is：1%~3%.
2. the soft capsule according to claim 1 prepared with wolfberry fruit extract with royal jelly or propolis, it is characterised in that：Institute
It includes wolfberry fruit extract activating agent to state additive.
3. a kind of preparation side of soft capsule for being prepared as claimed in claim 2 with wolfberry fruit extract with royal jelly or propolis
Method, it is characterised in that：Include the following steps：
Step 1：Removal of impurities；The royal jelly or propolis are melted under the conditions of 50 DEG C~60 DEG C, the distillation of equivalent is then added
Water stirs evenly, then is filtered with 80~100 mesh nylon gauzes, removes impurity therein；
Step 2：Charging；The wolfberry fruit extract is added in royal jelly or propolis after step 1 removal of impurities；
Step 3：Preliminary mixing；By containing wolfberry fruit extract in step 3 royal jelly or propolis tentatively mixed in canister
It closes and additive is added；
Step 4：Secondary mixing；By through tentatively mixing royal jelly or propolis and wolfberry fruit extract input in big tank, carry out secondary
Mixing；
Step 5：Vacuum dehydrating at lower temperature；By 100~150 mesh of the royal jelly containing wolfberry fruit extract of secondary mixing or propolis
Nylon gauze filters, and the filtered royal jelly containing wolfberry fruit extract or propolis are distributed into the pallet of vacuum freeze drier
In, the thickness of royal jelly or propolis containing wolfberry fruit extract is 8mm~10mm, or by filtered containing wolfberry fruit extract
Royal jelly or propolis are packed into the ampulla on ampulla frame, wouldn't be sealed, and are put freeze-drying interior into, are started vacuum freeze drying
The temperature of vacuum drying cabinet is down to -40 DEG C by machine, then makes vacuum degree control filtered containing matrimony vine in 10 ± 1mmHg
The royal jelly of extract or the temperature of propolis are maintained at -25 ± 2 DEG C, and the temperature of condenser is controlled at -50 ± 2 DEG C, while to cold
Freeze the heating of hothouse component, be transmitted to charging tray, promote water sublimed, detects the moisture of the royal jelly containing wolfberry fruit extract or propolis
Content is 1.5%~2.5%, that is, completes drying process, the royal jelly or bee glue powder containing wolfberry fruit extract that will be dried out
Dry powder is made after broken；
Step 6：Tabletting；By matrimony vine bee product freeze-dried powder made from step 5 through tableting process, it is 300 millis gram/piece that dosage, which is made,
Tablet, releasing agent is added in tablet forming technique；
Step 7：Packaging；Tablet in step 6 is fitted into soft capsule.
4. the preparation method of the soft capsule according to claim 3 prepared with wolfberry fruit extract with royal jelly or propolis,
It is characterized in that：Wolfberry fruit extract in the step 2 includes polysaccharides, matrimony vine lutein, bata-carotene, the matrimony vine
Polysaccharide, matrimony vine lutein, bata-carotene are in micro mist shape.
5. the preparation method of the soft capsule according to claim 4 prepared with wolfberry fruit extract with royal jelly or propolis,
It is characterized in that：Incorporation time in the step 3 is 4h~6h.
6. the preparation method of the soft capsule according to claim 5 prepared with wolfberry fruit extract with royal jelly or propolis,
It is characterized in that：Mixing speed when being mixed in the step 4 is 40r/min~60r/min.
7. the soft capsule prepared with wolfberry fruit extract with royal jelly or propolis according to any one of claim 3~6
Preparation method, it is characterised in that：Wolfberry fruit extract described in the step 3 uses ultrasonic sterilization.
8. the preparation method of the soft capsule according to claim 7 prepared with wolfberry fruit extract with royal jelly or propolis,
It is characterized in that：The power 250W of the ultrasonic wave, ultrasonic treatment time are 15 ± 2min.
9. the preparation method of the soft capsule according to claim 8 prepared with wolfberry fruit extract with royal jelly or propolis,
It is characterized in that：Envionmental humidity is less than 60% in the step 7.
10. the preparation method of the soft capsule according to claim 9 prepared with wolfberry fruit extract with royal jelly or propolis,
It is characterized in that：Wolfberry fruit extract in the step 2 is filtered with the mesh nylon yarn of 100 mesh~120.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109567188A (en) * | 2018-12-28 | 2019-04-05 | 江苏鸿祺生物科技有限公司 | A kind of health-care food composition and its preparation method and application of propolis-containing extract |
| CN109601936A (en) * | 2018-12-28 | 2019-04-12 | 江苏鸿祺生物科技有限公司 | A kind of propolis extract and its health-care food composition preventing senile dementia |
| CN109619511A (en) * | 2018-12-28 | 2019-04-16 | 江苏鸿祺生物科技有限公司 | A kind of composition and its preparation method and application of propolis-containing extract |
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| CN114081154A (en) * | 2021-12-08 | 2022-02-25 | 宁夏天然蜂产品科技开发有限责任公司 | High-nutrition propolis product and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109567188A (en) * | 2018-12-28 | 2019-04-05 | 江苏鸿祺生物科技有限公司 | A kind of health-care food composition and its preparation method and application of propolis-containing extract |
| CN109601936A (en) * | 2018-12-28 | 2019-04-12 | 江苏鸿祺生物科技有限公司 | A kind of propolis extract and its health-care food composition preventing senile dementia |
| CN109619511A (en) * | 2018-12-28 | 2019-04-16 | 江苏鸿祺生物科技有限公司 | A kind of composition and its preparation method and application of propolis-containing extract |
| CN113040394A (en) * | 2021-04-19 | 2021-06-29 | 江苏鸿祺生物科技有限公司 | Royal jelly polypeptide and preparation method and application thereof |
| CN115707478A (en) * | 2021-08-18 | 2023-02-21 | 昆药集团股份有限公司 | Composition with anti-aging effect and preparation method and application thereof |
| CN115707478B (en) * | 2021-08-18 | 2024-01-30 | 昆药集团股份有限公司 | Composition with anti-aging effect and preparation method and application thereof |
| CN114052230A (en) * | 2021-12-02 | 2022-02-18 | 宁夏天然蜂产品科技开发有限责任公司 | Bee product soft capsule food and preparation method thereof |
| CN114081154A (en) * | 2021-12-08 | 2022-02-25 | 宁夏天然蜂产品科技开发有限责任公司 | High-nutrition propolis product and preparation method thereof |
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