CN1085548C - Traditional Chinese medicinal prepns. for treating hepatitis B virus, and method for preparing same - Google Patents
Traditional Chinese medicinal prepns. for treating hepatitis B virus, and method for preparing same Download PDFInfo
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- CN1085548C CN1085548C CN99116108A CN99116108A CN1085548C CN 1085548 C CN1085548 C CN 1085548C CN 99116108 A CN99116108 A CN 99116108A CN 99116108 A CN99116108 A CN 99116108A CN 1085548 C CN1085548 C CN 1085548C
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Abstract
The present invention relates to a traditional Chinese medicine preparation for treating chronic hepatitis B viruses and a preparation method thereof. The Chinese patent medicine preparation prepared by compounding and processing about dry products of about ten kinds of Chinese herbal medicine is characterized in that the dry products of ten kinds of Chinese herbal medicine including bupleurum, radix astragau, rhiizoma dioscoreae, glossy privet fruit, tuckahoe, red sage root, capillary wormwood, giant knotweed rhizome, cyrtomium rhizome and liquorice are compounded and processed into the dosage forms of granules, mixtures and oral liquid. Compared with import interferon, the traditional Chinese medicine preparation has the advantages of similar negative conversion effect, easy acquisition of materials, rich medicine source, convenient administration (oral administration), obvious curative effect, few end-of-dose failure, no toxic or side effect and low required cost. Compared with other traditional Chinese medicine preparations, the traditional Chinese medicine preparation has the characteristics of favorable effect of liver protection and enzyme reduction on hepatitis b viruses besides favorable negative conversion therapeutic effect, increase of the immunological function of human bodies, clinically quick treatment of symptoms of patients, recovery of the liver function and negative conversion of HBV.
Description
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of Chinese medicine preparation for the treatment of chronic HBV and preparation method thereof belongs to the technical field of Chinese patent medicine and application process thereof.
At present the Chinese medicine preparation of the treatment chronic hepatitis B sold of market mostly is hepatoprotective, falls enzyme, and the Chinese medicine preparation of specially controlling hepatitis B virus converting negative seldom, cuts gradually because of uncertain therapeutic efficacy and eliminated as oral AOTAILE electuary, ZHULINGDUOTANG ZHUSHEYE.Treatment at present hepatitis b virus infected generally acknowledged be interferon than active drug, but there is following shortcoming in interferon: (1) medication inconvenience (needing continuous intramuscular injection), patient is not easy to accept; (2) toxic and side effects big (heating, systemic pain, alopecia, peripheral hemogram minimizing etc. can appear in patient in therapeutic process); (3) drug withdrawal is easily recurred; (4) required expense big (about 30,000 yuan to 50,000 yuan an of course of treatment), general patient can't bear expensive expense.
Because the unsatisfactory curative effect of Western medicine aspect treatment hepatitis B, therefore medical circle is studied the treatment by Chinese herbs method emphatically, Chinese patent discloses the Chinese medicine preparation of three kinds of treatment hepatitis ies, for example: the patent application of patent publication No. CN1192918A, " medicinal powder for treatment of hepatitis B and preparation method thereof " by name, product by dry big heat of suffering such as Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Ramulus Cinnamomi are formed, the physiological characteristics of liver is that " body is cloudy with sun ", sun are had a surplus and deficiency of YIN, and the hepatopath more should avoid hot warm-dryness syndrome heat and heavily yin nourishing; This prescription removes at the northwest cold district individual, is difficult in other most of area and uses and obtain effect.The patent application of patent publication No. CN1171257A, " a kind of Chinese herbal and crude drugs preparations and outfit method thereof of controlling hepatitis B " by name, its prescription is piled up and is formed by blood circulation and stasis-eliminating medicine (Radix Curcumae, Radix Notoginseng, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra etc.) and heat and toxic materials clearing away medicine (Radix Isatidis, Herba Scutellariae Barbatae, Caulis Lonicerae, Radix Scutellariae, Herba Patriniae, Herba Hedyotidis Diffusae etc.) two class medicines, not by traditional Chinese medical science principle-method-recipe-medicines principle prescription, and mostly be the product that bitter cold is invigorated blood circulation, prolonged application easily causes deteriorated blood, impairment of YANG, consumption the moon, there is not the spleen invigorating yin nourishing, the effect of human body immunity improving function.The patent application of patent publication No. CN1083712A, " a kind of medicine of preventing and treating hepatitis B " by name, its prescription stresses nourishing the liver and kidney, only be applicable to the liver-kidney yin deficiency hepatitis B, and the hepatitis B patient is not suitable for taking.Because above-mentioned its medicine group 5 of three Chinese medicine preparation is unreasonable, treatment hepatitis B treating rate is not high, do not see clinically and apply, and or not ideal therapeutic agent for hepatitis B therefore.
The objective of the invention is that the toxic and side effects that interferon exists is big, drug withdrawal is easily recurred in order to overcome, medication inconvenience, the high shortcoming of treatment cost, Chinese medicine preparation of the treatment hepatitis B virus that provide a kind of and have no side effect, drug withdrawal is difficult for recurrence, medication is convenient, the treatment cost is low and preparation method thereof.
Purpose of the present invention can reach by taking following measure: the Chinese medicine preparation of treatment chronic HBV, be characterized in: mainly be dissolved granule, mixture and the oral liquid of being made by following column weight amount Chinese medicinal raw materials, the shared weight ratio of described each raw material of Chinese medicine is as follows: Radix Bupleuri 5～25, Radix Astragali 10～40, Fructus Ligustri Lucidi 6～30, capillary wormwood 10～40, Rhizoma Polygoni Cuspidati 5～30, Rhizoma Osmundae 5-30, Radix Glycyrrhizae 3～10.
The purpose of invention also can reach by taking following measure:
Raw material of Chinese medicine also comprises as previously mentioned: Poria 10～30, Rhizoma dioscoreae 10～40, Radix Salviae Miltiorrhizae 5～30.
Raw material of Chinese medicine also comprises as previously mentioned: Rhizoma dioscoreae 10～40, Herba Patriniae 5～30, Herba Abri 10～40.
Raw material of Chinese medicine also comprises as previously mentioned: the Rhizoma Atractylodis Macrocephalae 5～25, Fructus Hordei Germinatus 10～40, Radix Salviae Miltiorrhizae 5～30.
Raw material of Chinese medicine also comprises as previously mentioned: Radix Curcumae 5～25, Fructus Hordei Germinatus 10～40, white Dorsal root leaf 5～25.
Raw material of Chinese medicine also comprises as previously mentioned: Semen Coicis 10～40, downy rosemyrtle root 10～30, Radix Salviae Miltiorrhizae 5～30.
The preparation method of the Chinese medicine preparation of foregoing treatment chronic HBV is characterized in: after taking by weighing each medicinal raw material dry product by weight, crude drug is decocted with water secondary, boiled the leaching medicinal liquid 2 hours for the first time; Added water boil again 1 hour, the leaching medicinal liquid; The medicinal liquid that merges twice leaching refilters, and filtered liquid medicine is concentrated into the gross weight of dried medical material; The ethanol precipitation of weight such as adding and concentrated solution left standstill 48 hours, filtered, and reclaimed ethanol; Add adjuvant after medicinal liquid concentrates and make granule, drying is calculated every bag grain amount by recipe quantity, makes dissolved granule.
The preparation method of the Chinese medicine preparation of foregoing treatment chronic HBV, be characterized in: after taking by weighing each medicinal raw material dry product by weight, use warm water soaking 1 hour earlier, decoct secondary, boiled 2 hours for the first time, boiled 1 hour for the second time, filter, merging filtrate also is concentrated into filtrate the gross weight of dried medical material; The ethanol precipitation of weight such as adding and concentrated solution leaves standstill, and filters, and reclaims ethanol; Be dissolved in water, filter, finished product is sterilized in embedding, is mixed with oral liquid.
The preparation method of the Chinese medicine preparation of foregoing treatment chronic HBV, be characterized in: after taking by weighing each medicinal raw material dry product by weight, crude drug is decocted with water secondary, boiled 2 hours for the first time, boiled 1 hour for the second time, filter, merging filtrate is with filtrate the being concentrated into weight that feeds intake, add ethanol precipitation, left standstill 48 hours, and filtered, reclaim ethanol; Medicinal liquid concentrates, and adds flavoring agent, calculates each oral dose by recipe quantity, is mixed with mixture.
The present invention has following outstanding advantage:
1. this Chinese medicine preparation is similar to the import efficacy of interferon therapy to the effect of turning out cloudy of hepatitis B virus, has to draw materials easily, and the medicine source is abundant, convenient drug administration (oral) determined curative effect, and end-of-dose failure is few, has no side effect, the advantage that required expense is few.
2. hepatitis B, Chinese medical discrimination often classify dampness-heat in the liver and gallbladder (initial stage, acute stage), stagnation of liver-QI with deficiency of the spleen (mid-term, chronic phase), the hepatic and renal YIN deficiency (middle and late stage, chronic phase), qi depression to blood stasis (latter stage) four types, the damp folder of holding concurrently between each pattern of syndrome of being everlasting.The clinical manifestation of chronic hepatitis B and chronic HbsAg carrier is with the wet major part that accounts for of stagnation of liver-QI with deficiency of the spleen folder.Modern medicine study shows; The imbalance of the persistent infection of hepatitis B virus and body's immunity is closely related, the hyperfunction and cellular immunity deficiency of hepatitis b patient liquid immunity.The prompting of modern Chinese medicine pharmacology; Drugs for nourishing yin has effect, the heat and toxic materials clearing away medicine of regulating cellular immunization and humoral immunization that stronger inhibition hepatitis B virus effect is arranged, and has antiinflammatory to suppress the humoral immunization effect.This preparation closes ginseng with Chinese and Western, and dialectical differential diagnosis of diseases is integrated as principle, at the wet cause of disease of stagnation of liver-QI with deficiency of the spleen folder, controls with spleen invigorating nourishing the liver, clearing away heat-damp and promoting diuresis, promptly suppresses hepatitis B virus, again the human body immunity improving function.It is monarch drug altogether that Radix Astragali air making-up and spleen enlivening in the side, Fructus Ligustri Lucidi are taken a tonic or nourishing food to build up one's health liver-yin, Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI; Poria invigorating spleen to remove dampness, Rhizoma dioscoreae spleen reinforcing (the moon) nourishing the stomach, are passed through from heat-clearing and toxic substances removing altogether for ministerial drug capillary wormwood, Rhizoma Polygoni Cuspidati; The Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling is an adjuvant drug; The Radix Glycyrrhizae mediation property of medicine is messenger drug.Full side becomes invigorating spleen to remove dampness altogether, yin nourishing is soothing the liver, the effect of the heat-clearing and toxic substances removing of invigorating blood circulation.
3. this preparation is except that having the good curative effect of turning out cloudy to hepatitis B virus, also have good hepatoprotective, fall the enzyme effect, and can improve the immunologic function of human body, can improve patient's symptom soon clinically, recover liver function, HBV is turned out cloudy, and energy stimulating appetite, reduce " flu ", health invigorating has that cost is low, the advantage of the definite effect of turning out cloudy.
Describe the present invention below in conjunction with embodiment:
Fig. 1 is the flow chart of preparation dissolved granule.
Fig. 2 is the flow chart of preparation oral liquid.
Fig. 3 is the flow chart of preparation mixture.
Embodiments of the invention 1 are: formed by 10 flavor Chinese herbal medicine dry product groups 5, this 10 flavor Chinese herbal medicine dry product is Radix Bupleuri, Radix Astragali, Rhizoma dioscoreae, Poria, Fructus Ligustri Lucidi, Radix Salviae Miltiorrhizae, capillary wormwood, Rhizoma Polygoni Cuspidati, Rhizoma Osmundae, Radix Glycyrrhizae group 5, the shared weight ratio of each component is Radix Bupleuri 6, Radix Astragali 20, Rhizoma dioscoreae 20, Poria 15, Fructus Ligustri Lucidi 10, Radix Salviae Miltiorrhizae 6, capillary wormwood 20, Rhizoma Polygoni Cuspidati 10, Rhizoma Osmundae 10, Radix Glycyrrhizae 10, by the good Chinese medicine dry product of aforementioned weight ratio weighing.
Preparation flow according to Fig. 1 is made dissolved granule.
According to Fig. 2 is that preparation flow is made oral liquid.
According to Fig. 3 is that preparation flow is made mixture.
Embodiments of the invention 2 are: formed by 10 flavor Chinese herbal medicine dry product groups 5, this 10 flavor Chinese herbal medicine dry product is Radix Bupleuri, Radix Astragali, Rhizoma dioscoreae, Poria, Fructus Ligustri Lucidi, Radix Salviae Miltiorrhizae, capillary wormwood, Rhizoma Polygoni Cuspidati, Rhizoma Osmundae, Radix Glycyrrhizae group 5, the shared weight ratio of each component is Radix Bupleuri 12, Radix Astragali 32, Rhizoma dioscoreae 33, Poria 12, Fructus Ligustri Lucidi 23, Radix Salviae Miltiorrhizae 12, capillary wormwood 33, Rhizoma Polygoni Cuspidati 23, Rhizoma Osmundae 18, Radix Glycyrrhizae 3, by the good Chinese medicine dry product of aforementioned weight ratio weighing.
Preparation flow according to Fig. 1 is made dissolved granule.
According to Fig. 2 is that preparation flow is made oral liquid.
According to Fig. 3 is that preparation flow is made mixture.
Embodiments of the invention 4 are: formed by 10 flavor Chinese herbal medicine dry product groups 5, this 10 flavor Chinese herbal medicine dry product is Radix Bupleuri, Radix Astragali, Rhizoma dioscoreae, Fructus Ligustri Lucidi, Herba Patriniae, capillary wormwood, Rhizoma Polygoni Cuspidati, Rhizoma Osmundae, Radix Glycyrrhizae, Herba Abri group 5, the shared weight ratio of each component is Radix Bupleuri 5～25, Radix Astragali 10～40, Rhizoma dioscoreae 10～40, Fructus Ligustri Lucidi 10～30, Herba Patriniae 5～30, capillary wormwood 10～40, Rhizoma Polygoni Cuspidati 5～30, Rhizoma Osmundae 3～30, Radix Glycyrrhizae 3～10, Herba Abri 10～40
Preparation flow according to Fig. 1 is made dissolved granule.
According to Fig. 2 is that preparation flow is made oral liquid.
According to Fig. 3 is that preparation flow is made mixture.
Embodiments of the invention 5 are: formed by 10 flavor Chinese herbal medicine dry product groups 5, this 10 flavor Chinese herbal medicine dry product is Radix Bupleuri, Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Fructus Hordei Germinatus, Radix Salviae Miltiorrhizae, capillary wormwood, Rhizoma Polygoni Cuspidati, Rhizoma Osmundae, Radix Glycyrrhizae group 5, the shared weight ratio of each component is Radix Bupleuri 5～25, Radix Astragali 10～40, the Rhizoma Atractylodis Macrocephalae 5～25, Fructus Ligustri Lucidi 10～30, Fructus Hordei Germinatus 10～40, Radix Salviae Miltiorrhizae 5～30, capillary wormwood 10～40, Rhizoma Polygoni Cuspidati 5～30, Rhizoma Osmundae 3～30, Radix Glycyrrhizae 3～10
Preparation flow according to Fig. 1 is made dissolved granule.
According to Fig. 2 is that preparation flow is made oral liquid.
According to Fig. 3 is that preparation flow is made mixture.
Embodiments of the invention 6 are: formed by 9 flavor Chinese herbal medicine dry product groups 5, this 9 flavor Chinese herbal medicine dry product is Radix Bupleuri, Radix Astragali, Rhizoma dioscoreae, Fructus Ligustri Lucidi, Radix Curcumae, capillary wormwood, Herba Abri, Rhizoma Osmundae, Radix Glycyrrhizae group 5, the shared weight ratio of each component is Radix Bupleuri 5～25, Radix Astragali 10～40, Rhizoma dioscoreae 10～40, Fructus Ligustri Lucidi 10～30, Radix Curcumae 5～25, capillary wormwood 10～40, Herba Abri 10～40, Rhizoma Osmundae 5～30, Radix Glycyrrhizae 3～10
Preparation flow according to Fig. 1 is made dissolved granule.
According to Fig. 2 is that preparation flow is made oral liquid.
According to Fig. 3 is that preparation flow is made mixture.
Embodiments of the invention 7 are: formed by 9 flavor Chinese herbal medicine dry product groups 5, this 9 flavor Chinese herbal medicine dry product is Radix Bupleuri, Radix Astragali, Fructus Ligustri Lucidi, Radix Curcumae, Fructus Hordei Germinatus, white Dorsal root leaf, capillary wormwood, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae group 5, the shared weight ratio of each component is Radix Bupleuri 5～25, Radix Astragali 10～40, Fructus Ligustri Lucidi 10～30, Radix Curcumae 5～25, Fructus Hordei Germinatus 10～40, white Dorsal root leaf 5～25, capillary wormwood 10～40, Rhizoma Polygoni Cuspidati 5～30, Radix Glycyrrhizae 3～10
Preparation flow according to Fig. 1 is made dissolved granule.
According to Fig. 2 is that preparation flow is made oral liquid.
According to Fig. 3 is that preparation flow is made mixture.
Embodiments of the invention 8 are: formed by 9 flavor Chinese herbal medicine dry product groups 5, this 9 flavor Chinese herbal medicine dry product is Radix Bupleuri, Radix Astragali, Fructus Ligustri Lucidi, Semen Coicis, capillary wormwood, downy rosemyrtle root, Radix Salviae Miltiorrhizae, Rhizoma Osmundae, Radix Glycyrrhizae group 5, the shared weight ratio of each component is Radix Bupleuri 5～25, Radix Astragali 10～40, Fructus Ligustri Lucidi 10～30, Semen Coicis 10～40, capillary wormwood 10～40, downy rosemyrtle root 10～30, Radix Salviae Miltiorrhizae 5～30, Rhizoma Osmundae 5～30, Radix Glycyrrhizae 3～10, is processed into dissolved granule, mixture, oral liquid type.
Preparation flow according to Fig. 1 is made dissolved granule.
Preparation flow according to Fig. 2 is made oral liquid.
According to Fig. 3 is that preparation flow is made mixture.
Claims (9)
1. treat the Chinese medicine preparation of chronic HBV, it is characterized in that: mainly be dissolved granule, mixture and the oral liquid of being made by following Chinese medicine raw materials by weight proportion, the shared weight ratio of described each raw material of Chinese medicine is Radix Bupleuri 5～25, Radix Astragali 10～40, Fructus Ligustri Lucidi 6～30, capillary wormwood 10～40, Rhizoma Polygoni Cuspidati 5～30, Rhizoma Osmundae 5-30, Radix Glycyrrhizae 3～10.
2. the Chinese medicine preparation of treatment chronic HBV according to claim 1 is characterized in that: described raw material of Chinese medicine also comprises: Poria 10～30, Rhizoma dioscoreae 10～40, Radix Salviae Miltiorrhizae 5～30.
3. the Chinese medicine preparation of treatment chronic HBV according to claim 1 is characterized in that: described raw material of Chinese medicine also comprises: Rhizoma dioscoreae 10～40, Herba Patriniae 5～30, Herba Abri 10～40.
4. the Chinese medicine preparation of treatment chronic HBV according to claim 1 is characterized in that: described raw material of Chinese medicine also comprises: the Rhizoma Atractylodis Macrocephalae 5～25, Fructus Hordei Germinatus 10～40, Radix Salviae Miltiorrhizae 5～30.
5. the Chinese medicine preparation of treatment chronic HBV according to claim 1 is characterized in that: described raw material of Chinese medicine also comprises: Radix Curcumae 5～25, Fructus Hordei Germinatus 10～40, white Dorsal root leaf 5～25.
6. the Chinese medicine preparation of treatment chronic HBV according to claim 1 is characterized in that: described raw material of Chinese medicine also comprises: Semen Coicis 10～40, downy rosemyrtle root 10～30, Radix Salviae Miltiorrhizae 5～30.
7. as the preparation method of the Chinese medicine preparation of the described treatment chronic HBV of arbitrary claim in the claim 1 to 6, it is characterized in that: after taking by weighing each medicinal raw material dry product by weight, crude drug is decocted with water secondary, boiled the leaching medicinal liquid 2 hours for the first time; Added water boil again 1 hour, the leaching medicinal liquid; The medicinal liquid that merges twice leaching refilters, and filtered liquid medicine is concentrated into the gross weight of dried medical material; The ethanol precipitation of weight such as adding and concentrated solution left standstill 48 hours, filtered, and reclaimed ethanol; Add adjuvant after medicinal liquid concentrates and make granule, drying is made dissolved granule.
8. as the preparation method of the Chinese medicine preparation of the described treatment chronic HBV of arbitrary claim in the claim 1 to 6, it is characterized in that: after taking by weighing each medicinal raw material dry product by weight, use warm water soaking 1 hour earlier, decoct secondary, boiled 2 hours for the first time, boiled 1 hour for the second time, filter, merging filtrate also is concentrated into filtrate the gross weight of dried medical material; The ethanol precipitation of weight such as adding and concentrated solution leaves standstill, and filters, and reclaims ethanol; Be dissolved in water, filter, finished product is sterilized in embedding, is mixed with oral liquid.
9. as the preparation method of the Chinese medicine preparation of the described treatment chronic HBV of arbitrary claim in the claim 1 to 6, it is characterized in that: after taking by weighing each medicinal raw material dry product by weight, crude drug is decocted with water secondary, boiled 2 hours for the first time, boiled 1 hour for the second time, filter, merging filtrate is with filtrate the being concentrated into weight that feeds intake, add ethanol precipitation, left standstill 48 hours, and filtered, reclaim ethanol; Medicinal liquid concentrates, and adds flavoring agent, is mixed with mixture.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99116108A CN1085548C (en) | 1999-03-31 | 1999-03-31 | Traditional Chinese medicinal prepns. for treating hepatitis B virus, and method for preparing same |
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| Application Number | Priority Date | Filing Date | Title |
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| CN99116108A CN1085548C (en) | 1999-03-31 | 1999-03-31 | Traditional Chinese medicinal prepns. for treating hepatitis B virus, and method for preparing same |
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| CN1233501A CN1233501A (en) | 1999-11-03 |
| CN1085548C true CN1085548C (en) | 2002-05-29 |
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| CN99116108A Expired - Fee Related CN1085548C (en) | 1999-03-31 | 1999-03-31 | Traditional Chinese medicinal prepns. for treating hepatitis B virus, and method for preparing same |
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| CN103330034A (en) * | 2013-07-16 | 2013-10-02 | 太仓市伟基生物科技有限公司 | Liver soothing and toxin removal tea |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101281A (en) * | 1994-03-15 | 1995-04-12 | 赵壁修 | Preparation of ke'ao Jiugan Lin |
| CN1102591A (en) * | 1993-11-06 | 1995-05-17 | 薛洪涛 | "Sanmiao" compound mixture and its prescription |
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1999
- 1999-03-31 CN CN99116108A patent/CN1085548C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1102591A (en) * | 1993-11-06 | 1995-05-17 | 薛洪涛 | "Sanmiao" compound mixture and its prescription |
| CN1101281A (en) * | 1994-03-15 | 1995-04-12 | 赵壁修 | Preparation of ke'ao Jiugan Lin |
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