CN1061885C - Specific infusion for hepatitis B and producing process thereof - Google Patents
Specific infusion for hepatitis B and producing process thereof Download PDFInfo
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- CN1061885C CN1061885C CN97118326A CN97118326A CN1061885C CN 1061885 C CN1061885 C CN 1061885C CN 97118326 A CN97118326 A CN 97118326A CN 97118326 A CN97118326 A CN 97118326A CN 1061885 C CN1061885 C CN 1061885C
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Abstract
The present invention relates to specific infusion for hepatitis B, which is novel traditional Chinese preparation prepared by compounding fifteen kinds of traditional Chinese medicine comprising ganoderma, etc. through preparation and pulverization. The present invention can be soaked by boiled water at 80 to 100 DEG C, and obtained juice can be drunk. The clinical verification of more than 1000 patients of chronic hepatitis B and asymptomatic HBV carriers shows that the present invention has the functions of regulating immunologic mechanisms, resisting HBV and hepatic lesion, replenishing blood, protecting the liver, reducing enzymes and preventing liver cirrhosis and cancerization. When patients are systemically treated for 3 to 5 months, both e antigen negative converting rate and e antibody positive converting rate are above 90%, and both surface antigen negative converting rate and surface antibody positive converting rate are as high as 60 to 80%.
Description
The present invention relates to a kind of Chinese medicine preparation and processing method thereof, exactly is a kind of bubble powder and processing method thereof for the treatment of hepatitis B.
Hepatitis B (abbreviation hepatitis B) is infected by hepatitis B virus (HBV) and causes, is the infectious disease of principal character with immune liver injury.Hepatitis B is worldwide popular.China is the district occurred frequently.Confirm that according to for the second time national viral hepatitis Epidemiological study national hepatitis B prevalence rate is 9.75%.Hepatitis B is not only popular wide, and the treatment difficulty is big, is prone to knock-on after patient's drug withdrawal, the relapse rate height, and part patient can develop into liver cirrhosis and hepatocarcinoma, and human beings'health in serious threat.
The medicine of treatment hepatitis B is broadly divided into following four classes at present:
One class is an antiviral agents, mainly contains interferon and several nucleoside analog.Wherein interferon suppresses the hbv replication effect certainly, after 3～6 months courses of treatment, and e antigen and HBV～DNA negative conversion rate 30～60%, but the surface antigen negative conversion rate is low, and cost an arm and a leg, certain toxic and side effects is arranged.
One class is an immunomodulator, mainly contains thymosin, transfer factor, interleukin-2 etc.Many and other drug is united use.
One class is a hepatoprotective, mainly contains bifendate, glycyrrhizin, silymarin, left-handed catechin etc.The anti-hepatocellular damage of this type of medicine, recovery liver function aspect curative effect are affirmed, but not anti-HBV.
One class is to protect the liver and the comprehensive medicine that uses of anti-HBV, and this type of mostly is Chinese medicine, and is various in style, is the gesture that a hundred flowers blossom.Its composition principle is used methods such as heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, nourishing YIN and invigorating YANG, strengthening the body resistance, spleen invigorating dehumidifying, easing the affected liver resolving depression more, the Chinese medicine of the anti-hepatic injury of compatibility, anti-HBV, the prescription of composition " cocktail type ".It is at the liver protecting and ALT lowering and prevent aspect the hepatic fibrosis certain curative effect is arranged.The part curative effect is being arranged aspect the anti-HBV.This type of medicine multi-processing becomes powder, when taking or fry in shallow oil or boil or soak, and drink juice waste.It is fast to decoct absorption, and the drug effect performance is fast, but very inconvenient concerning long-term pill taker, decocts utensil inconvenience and carries, and in addition, the different phenomenon of a medicine also can appear in amount of water, decocting time, affects the treatment.Though boiling water soaks more convenient than decocting, the boiling water consumption, soak number of times, Time of Administration etc. and can't unify, again and again drink as health promoting beverage still can, not proper as medicine.
The present invention improves traditional powder, develops Chinese medicine novel form bubble powder, and being intended to provides a kind of specific Chinese medicine for hepatitis B patient.
The hepatitis B patient immunologic function disorder, especially cellular immunity is low, thereby can not remove HBV effectively.Because HBV invades and harasses for a long time, forces body constantly to carry out immunoreation, finally cause the immunological liver infringement, as a series of pathological changes such as hepatic necrosis, immune complex deposit and hepatic fibrosis.Based on above theory, the present invention treats hepatitis B by immunity and two of antiviral by way of the synergism of anti-HBV and protecting the liver of assisting, anti-hepatic injury, specifically select for use following ten Chinese medicine of the five flavours after special handling in proportion (mass ratio) be processed into bubble powder;
Processed with wine Ganoderma powder 4.5% decoction of black soybean yellow wine Radix Polygoni Multiflori Preparata powder 4.5%
Processed with wine Cortex Magnoliae Officinalis powder 4.5% Radix Glycyrrhizae (processed with honey) powder 4.5%
Processed with wine turmeric powder 6.0% Radix Scutellariae (processed with wine) powder 6.0%
Herba Dendranthematis indici pollen 6.0% processed with wine Poria powder 7.4%
Processed with wine Fructus Ligustri Lucidi powder 7.4% processed with wine Radix Bupleuri powder 7.4%
Processed with wine Rhizoma Polygoni Cuspidati powder 7.4% Fructrs Jujubae Powder 7.4%
Radix Salviae Miltiorrhizae (processed with wine) powder 9.0% Radix Angelicae Sinensis (processed with wine) powder 9.0%
Radix Astragali (processed with Mel) powder 9.0%
In the above prescription, pair cell immunity such as Ganoderma, the Radix Polygoni Multiflori, the Radix Astragali, Fu Ling, Fructus Ligustri Lucidi and humoral immunization have dual regulation, and low immunologic function is strengthened, and are unlikely hyperfunction again.Radix Bupleuri, Rhizoma Polygoni Cuspidati, Radix Curcumae, Cortex Magnoliae Officinalis, Flos Chrysanthemi Indici etc. can effectively be alleviated the clinical symptoms of hepatitis B patient such as abdominal distention, liver pain, jaundice etc., and surface antigen and e antigen are had significant inhibitory effect.Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Radix Curcumae have blood circulation promoting and blood stasis dispelling, microcirculation improvement, the effect of increase hepatic blood flow, can effectively remove sedimentary immune complex.There are most of medicine such as Ganoderma, the Radix Polygoni Multiflori, Radix Scutellariae, Fructus Ligustri Lucidi, the Radix Astragali, Fructus Jujubae, Radix Glycyrrhizae, Poria, Radix Angelicae Sinensis, Radix Bupleuri, Radix Curcumae etc. that in various degree hepatoprotective effect is all arranged in the prescription, pass through antiallergic action, the anti-hepatic injury of effect such as blocking immunity medium release, as prevent immunological liver infringement and autoimmune hepatitis etc.
More than 15 flavor medicines be powdery, obviously its processing needs dry and pulverizes, can be dry after removing impurity as Flos Chrysanthemi Indici, Fructus Jujubae (enucleation), pulverize then and obtain Herba Dendranthematis indici pollen and Fructrs Jujubae Powder.Described special handling is meant that other 13 flavor medicines big guns before drying process processing.Division is as follows:
The preparation of radix polygoni multiflori powder: get Radix Polygoni Multiflori with Semen sojae atricolor juice, yellow wine in 1: 0.2～0.3: 0.2～0.3 ratio (mass ratio, down with) mix is even, put in the container airtight, place water-bath to heat in container, treat that Semen sojae atricolor juice and yellow wine are adsorbed the back fully by the Radix Polygoni Multiflori and take out, crushed after being dried obtains decoction of black soybean yellow wine Radix Polygoni Multiflori Preparata powder again.
Semen sojae atricolor juice adds water boil by Semen sojae atricolor, reconcentration and getting after filtering, 1 part of Semen sojae atricolor process 2～3 portions of juice.
The preparation of Fructus Ligustri Lucidi powder: it is even in 1: 0.1～0.2 ratio mix with yellow wine to get Fructus Ligustri Lucidi, and it is interior airtight to put container, places water-bath to heat in container, treats that yellow wine is adsorbed the back fully by Fructus Ligustri Lucidi and takes out, and crushed after being dried obtains the processed with wine Fructus Ligustri Lucidi powder again.
The preparation of other processed with wine powder: it is even in 1: 0.1～0.2 ratio mix with yellow wine to get the product of giving birth to decoction pieces, put in the container airtight, moistening is 4～24 hours under the room temperature, takes out then to pulverize after drying to obtain processed with wine Ganoderma powder, processed with wine volt Siberian cocklebur powder, Radix Angelicae Sinensis (processed with wine) powder, processed with wine Radix Bupleuri powder, processed with wine Rhizoma Polygoni Cuspidati powder, processed with wine Cortex Magnoliae Officinalis powder, Radix Salviae Miltiorrhizae (processed with wine) powder, Radix Scutellariae (processed with wine) powder, processed with wine turmeric powder.
The preparation of processed with honey powder: it is even in 1: 0.2～0.3 ratio mix with Mel to get the product of giving birth to decoction pieces, and it is interior airtight to put container, and moistening is 4～24 hours under the room temperature, takes out then to pulverize after drying to obtain Radix Astragali (processed with Mel) powder, Radix Glycyrrhizae (processed with honey) powder.
Above-mentioned 15 flavor medicated powder are mixed in proportion, behind sterilization, metering packing, promptly get and steep powder.
Bubble powder is different from traditional powder.Patient in timing, quantitatively brew its juice of drink with 80～100 ℃ boiled water.Because most of medicine is processed through meticulous big gun and is powdery, thus with decoct agent equally have effective ingredient discharge fast, discharge thoroughly, the patient absorbs soon, the drug effect advantage of performance rapidly, the comparable decoction agent saving of same effect medical material 1/3～1/2.Bubble powder dosage is unified, and volume is little, easily stores and carries, and the patient that needs are taken medicine for a long time is particularly convenient.
The applicant is through the arduous exploration of more than ten years, perfect prescription and preparation technology at the beginning of 94, routine chronic viral hepatitis B patient and the clinical verification of asymptomatic HBV carrier surplus 1000 again in the past few years, the present invention have the function of regulating immunologic mechanism, anti-HBV and anti-hepatic injury and enrich blood, protect the liver, fall enzyme, prevent the effect of liver cirrhosis and canceration.The patient is through 3～5 months systematic treating, and e antigen is cloudy to be changeed, e antibody male rotary rate is all more than 90%, and surface antigen is cloudy to be changeed, surface antibody sun rate of rotation reaches 60～80%, and wherein the patient 50% or more can be healed after treating in 3 months entirely.Have no side effect and untoward reaction.
Embodiment:
1, get each 1 kilogram in Flos Chrysanthemi Indici, Fructus Jujubae (enucleation), remove in the rearmounted vacuum drying oven of impurity, drying is 2～3 hours under 60～80 ℃ of conditions, pulverizes sieve after the cooling No. two, promptly gets Herba Dendranthematis indici pollen and Fructrs Jujubae Powder.Standby.
2, get 1 kilogram of Radix Polygoni Multiflori piece, 0.25 kilogram of decoction of black soybean 0.3, yellow wine, one mix is even, puts in the container and seals, and container is put in the water-bath heated, treat that juice and yellow wine are by absorption back discharging fully, the Radix Polygoni Multiflori of absorption juice and yellow wine is put in the vacuum drying oven, and drying is 3～5 hours under 80 ℃ of conditions, pulverizes sieve after the cooling No. two, promptly get decoction of black soybean yellow wine Radix Polygoni Multiflori Preparata powder, standby.
3, get 1 kilogram of Fructus Ligustri Lucidi, even with 0.2 kilogram of yellow wine mix, put in the container and seal, container put in the water-bath heat, treat that yellow wine by absorption back discharging fully, puts the Fructus Ligustri Lucidi that is adsorbed with yellow wine in the vacuum drying oven, drying is 3～5 hours under 80 ℃ of conditions, pulverize sieve after the cooling No. two, promptly got the processed with wine Fructus Ligustri Lucidi powder, standby
4, get 1 kilogram of the product of giving birth to decoction pieces Radix Angelicae Sinensis, even with 0.1～0.2 kilogram yellow wine mix, put airtight container inner room relaxing the bowels with purgatives of warm nature moistening 4～24 hours, taking-up is put in the vacuum drying oven, drying is 2～3 hours under 60～80 ℃ of conditions, pulverizes sieve after the cooling No. two, promptly gets the Radix Angelicae Sinensis (processed with wine) powder.The processing that uses the same method obtains processed with wine Ganoderma powder, processed with wine volt Siberian cocklebur powder, processed with wine Radix Bupleuri powder, processed with wine Rhizoma Polygoni Cuspidati powder, processed with wine turmeric powder, processed with wine Cortex Magnoliae Officinalis powder, Radix Salviae Miltiorrhizae (processed with wine) powder, Radix Scutellariae (processed with wine) powder, and is standby.
5, get each 1 kilogram in the Radix Astragali, Radix Glycyrrhizae, even with 0.25 kilogram Mel mix respectively, put airtight container inner room relaxing the bowels with purgatives of warm nature moistening 4～24 hours, take out in the rearmounted vacuum drying oven, drying is 3～5 hours under 70 ℃ of conditions, pulverize sieve after the cooling No. two, promptly got Radix Astragali (processed with Mel) powder and Radix Glycyrrhizae (processed with honey) powder, standby.
The method that the traditional slow fire of the also available traditional Chinese medical science of exsiccant method bakes, but must not material is burned.
Got 4 hours summer moistening time, got winter 24 hours.
Cross No. two sieve series and must be coarse powder, thinner in theory its effective ingredient more easily disengages, but empirical evidence, the coarse powder of crossing No. two sieves has adapted to the requirement of clinical treatment.
6, get processed with wine Ganoderma powder 300 grams, decoction of black soybean yellow wine Radix Polygoni Multiflori Preparata powder 300 grams, processed with wine Cortex Magnoliae Officinalis powder 300 grams, Radix Glycyrrhizae (processed with honey) powder 300 grams, Herba Dendranthematis indici pollen 400 grams, processed with wine turmeric powder 400 grams, Radix Scutellariae (processed with wine) powder 400 grams, processed with wine Poria powder 500 grams, processed with wine Fructus Ligustri Lucidi powder 500 grams, processed with wine Radix Bupleuri powder 500 grams, processed with wine Rhizoma Polygoni Cuspidati powder 500 grams, Fructrs Jujubae Powder 500 grams, Radix Salviae Miltiorrhizae (processed with wine) powder 600 grams, Radix Angelicae Sinensis (processed with wine) powder 600 grams, Radix Astragali (processed with Mel) powder 600 grams, add up to 6700 grams, in mixer, stir together, ultraviolet sterilization again, at last, pack with small plastic bag, every bag of net weight 33.5 grams add up to 200 bags.
Instructions of taking: 33.5 gram mixed powders are placed cup, add 80～100 ℃ 300～350 milliliters in boiled water, fully stir, add a cover and leave standstill half an hour approximately, treat the medicinal residues post precipitation, a drink-service medicine juice, slag stays in cup.Add 250～300 milliliters in 80～100 ℃ of boiled water after two hours again, fully stir, add a cover and leave standstill half an hour approximately, a drink-service medicine juice, slag discards.The medicine juice sepia, mildly bitter flavor can add an amount of sucrose flavoring.
Coming-of-Age Day obeys twice, each one bag.10～15 one full year of life minors reduce by half.Three months first courses of treatment, two months second courses of treatment.Drug withdrawal is 20 days between two courses of treatment.It is yellow that patient's period in a medicine urine is, and promptly changes clear after the drug withdrawal.Febrile disease, anemia of pregnant woman, infant forbidding.
Claims (2)
1, a kind of bubble powder for the treatment of hepatitis B, the Chinese medicine after being processed by big gun is formed, and it is characterized in that:
Processed with wine Ganoderma powder 4.5% decoction of black soybean yellow wine Radix Polygoni Multiflori Preparata powder 4.5%
Processed with wine Cortex Magnoliae Officinalis powder 4.5% Radix Glycyrrhizae (processed with honey) powder 4.5%
Processed with wine turmeric powder 6.0% Radix Scutellariae (processed with wine) powder 6.0%
Herba Dendranthematis indici pollen 6.0% processed with wine Poria powder 7.4%
Processed with wine Fructus Ligustri Lucidi powder 7.4% processed with wine Radix Bupleuri powder 7.4%
Processed with wine Rhizoma Polygoni Cuspidati powder 7.4% Fructrs Jujubae Powder 7.4%
Radix Salviae Miltiorrhizae (processed with wine) powder 9.0% Radix Angelicae Sinensis (processed with wine) powder 9.0%
Radix Astragali (processed with Mel) powder 9.0%.
2, the processing method of the bubble powder of the treatment hepatitis B of claim 1, by big gun process, dry, pulverize and mix sterilization, pack each unit process and constituted, it is characterized in that:
(1) it is even in 1: 0.2～0.3: 0.2～0.3 ratio mix with Semen sojae atricolor juice and yellow wine to get Radix Polygoni Multiflori, puts in the hermetic container and heats in water-bath, treats that juice and yellow wine are taken out by absorption back fully, dry again, pulverize;
(2) it is even in 1: 0.1～0.2 ratio mix with yellow wine to get Fructus Ligustri Lucidi, puts in the hermetic container and heats in water-bath, treats that yellow wine is taken out by absorption back fully, dry again, pulverize;
(3) it is even in 1: 0.1～0.2 ratio mix with yellow wine respectively to get Ganoderma, Fu Ling, Radix Angelicae Sinensis, Radix Bupleuri, Rhizoma Polygoni Cuspidati, Cortex Magnoliae Officinalis, Radix Salviae Miltiorrhizae, Radix Scutellariae, Radix Curcumae, puts hermetic container inner room relaxing the bowels with purgatives of warm nature moistening and takes out after 4～24 hours, dry again, pulverize;
(4) it is even in 1: 0.2～0.3 ratio mix with Mel respectively to get the Radix Astragali, Radix Glycyrrhizae, puts hermetic container inner room relaxing the bowels with purgatives of warm nature moistening and takes out after 4～24 hours, dry again, pulverize.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97118326A CN1061885C (en) | 1997-09-18 | 1997-09-18 | Specific infusion for hepatitis B and producing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97118326A CN1061885C (en) | 1997-09-18 | 1997-09-18 | Specific infusion for hepatitis B and producing process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1175459A CN1175459A (en) | 1998-03-11 |
| CN1061885C true CN1061885C (en) | 2001-02-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN97118326A Expired - Fee Related CN1061885C (en) | 1997-09-18 | 1997-09-18 | Specific infusion for hepatitis B and producing process thereof |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100381160C (en) * | 2005-12-07 | 2008-04-16 | 陈计强 | Chinese medicine for treating B-type hepatitis |
| CN107362329A (en) * | 2017-07-20 | 2017-11-21 | 闫鹏生 | A kind of Chinese medicine treated hepatitis B great three positive and turned out cloudy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1104903A (en) * | 1994-01-03 | 1995-07-12 | 张志霖 | Prepairing method for liver curing pill |
| CN1136939A (en) * | 1995-10-10 | 1996-12-04 | 卢颖 | Chinese drugs for curing hepatitis B |
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1997
- 1997-09-18 CN CN97118326A patent/CN1061885C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1104903A (en) * | 1994-01-03 | 1995-07-12 | 张志霖 | Prepairing method for liver curing pill |
| CN1136939A (en) * | 1995-10-10 | 1996-12-04 | 卢颖 | Chinese drugs for curing hepatitis B |
Non-Patent Citations (3)
| Title |
|---|
| 《四川中医》13(7) 1995.7.31 宋代义，益肝解毒汤治疗慢性肝炎的临床研究 * |
| 《福建中医药》23(2) 1991.2.28 吴克山，乙肝病毒携带者100例 * |
| 《福建中医药》23(2) 1991.2.28 吴克山，乙肝病毒携带者100例;《四川中医》13(7) 1995.7.31 宋代义，益肝解毒汤治疗慢性肝炎的临床研究 * |
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| Publication number | Publication date |
|---|---|
| CN1175459A (en) | 1998-03-11 |
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