CN108553528A - Anti-additive medicament and preparation method thereof - Google Patents
Anti-additive medicament and preparation method thereof Download PDFInfo
- Publication number
- CN108553528A CN108553528A CN201810812066.9A CN201810812066A CN108553528A CN 108553528 A CN108553528 A CN 108553528A CN 201810812066 A CN201810812066 A CN 201810812066A CN 108553528 A CN108553528 A CN 108553528A
- Authority
- CN
- China
- Prior art keywords
- parts
- weight
- drug
- additive medicament
- raw material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A kind of anti-additive medicament of present invention proposition and preparation method thereof, belongs to biologic product technology field, can have specific drug abstinence for opium drug habituation, have the characteristics that rapid-action, effect is strong.The anti-additive medicament is made of the raw material of following parts by weight：Premna microphylla Turez 15 25, small pheasant tail grass 10 15, Sculellaria barbata 15 30, Radix Polygalae 10 15, phoenix-tail fern 15 30, spina date seed 10 30, ganoderma lucidum 49, cordyceps sinensis 39 and mock-strawberry 15 30.Anti-additive medicament provided by the invention can play excellent effect to the detoxification of opioid addiction person.
Description
Technical field
The invention belongs to biologic product technology fields more particularly to a kind of anti-additive medicament and preparation method thereof.
Background technology
Drugs refer to those using the rear substance for allowing behavior, mood, attention, thinking and the will of people to change,
It can make one to generate psychological dependence and physiological dependence.Drugs have illegal drug and legal drugs, wherein legal drugs refer to perfume (or spice)
Cigarette, alcohol, hypnotic sedative agent and stable class drug etc., illegal drug refer to opium, heroin, morphine, cocaine, hemp,
An Feita, methamphetamine etc..
Drugs can damage the brain of people first, influence central nervous system function, and unconsciousness, anxiety, depression can occur
Deng.Some generates hostility conflict to people, induces amentia, bigoted and vain hope；Secondly, cardio cerebral function is influenced, brain can be made to remember
Recall power and attention, calculate power and judgment decline, make one thought slowness, react force difference, and immune function is made to decline, be easy by
Various viruses and bacterium infection；Again, normal reproductive ability and the imbalance function of muscular movement can be influenced.
The sides such as international so far, domestic generally use " frozen sleep " " diminishing method " " method of combatting poison with poison " " with mild toxicity for big poison "
Method is treated, but the above therapy is unscientific, fundamentally can't resolve influence and presence of the drugs in the person.Example
Such as, methadone inherently morphine belongs to substance, and the drug rehabilitation time is long, it is important to which relapse rate is high, and thorough drug rehabilitation is finally not achieved
Ideal and requirement.Chinese herbal medicine is the medical rarity of my Chinese nation, and Chinese herbal medicine can not only cure the disease, more can comprehensively regulating human body machine
Can, it enhances human immunity, therefore, it is that drug research circle and pharmacy corporation are urgently captured to develop efficient Chinese herbal medicine class drug-breaking medicine
Problem.
Invention content
A kind of anti-additive medicament of present invention proposition and preparation method thereof, the anti-additive medicament have opium drug habituation bright
True drug abstinence has the characteristics that rapid-action, effect is strong.
In order to achieve the above object, the present invention provides a kind of anti-additive medicaments, are made of the raw material of following parts by weight：
Premna microphylla Turez 15-25, small pheasant tail grass 10-15, Sculellaria barbata 15-30, Radix Polygalae 10-15, phoenix-tail fern 15-30, spina date seed
10-30, ganoderma lucidum 4-9, cordyceps sinensis 3-9 and mock-strawberry 15-30.
Preferably, being made of the bulk pharmaceutical chemicals of following parts by weight：
Premna microphylla Turez 20-25, small pheasant tail grass 10-15, Sculellaria barbata 20-30, Radix Polygalae 10-15, phoenix-tail fern 20-30, spina date seed
15-30, ganoderma lucidum 6-9, cordyceps sinensis 5-9 and mock-strawberry 20-30.
The preparation method for the anti-additive medicament that the present invention also provides a kind of as described in above-mentioned technical proposal, including following step
Suddenly：
By picking of raw material decontamination, clean, dry after, according to parts by weight mixture, packed after crushing；
The sterile purified water of sacked material and 8-20 times of weight is impregnated 1-5 days in sterile chamber；
Soak is put into togerther first intense fire in container with the sacked material impregnated to boil, then slow boiling is kept for 30-60 points
Clock obtains lysate, filtering, and the bottling of filtrate high temperature sterilization is made.
The preparation method for the anti-additive medicament that the present invention also provides a kind of as described in above-mentioned technical proposal, including following step
Suddenly：
By picking of raw material decontamination, clean, dry after, according to parts by weight mixture, packed after crushing；
The sterile purified water of sacked material and 8-20 times of weight is impregnated 1-5 days in sterile chamber；
Soak is put into togerther first intense fire in container with the sacked material impregnated to boil, then slow boiling is kept for 30-60 points
Clock obtains lysate, filtering, filtrate is condensed into thick paste, dry, crushing, then be incorporated appropriate medical accessory and can be made into medicine
Upper acceptable any dosage form.
Compared with prior art, the advantages and positive effects of the present invention are：
Anti-additive medicament provided by the present invention is suitable for having a running nose caused by abuse opioid drug, sneeze, disposition is tired
The symptoms such as hot-tempered, irritability, shortness of breath uncomfortable in chest, weak, can enhance body immunity, improve a poor appetite, tranquilizing the mind relieving restlessness, improve sleep quality,
Excellent effect is played for the detoxification of opioid addiction person.The drug itself be free of anesthetic composition, long term usage not will produce according to
Lai Xing, taking the breaking-out of 20 minutes or so drug addiction, symptoms start to alleviate, and even served four to seven days patients can be from mentally breaking away from drugs
Temptation.
Specific implementation mode
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
The every other embodiment that technical staff is obtained without making creative work belongs to the model that the present invention protects
It encloses.
An embodiment of the present invention provides a kind of anti-additive medicaments, are made of the raw material of following parts by weight：It is Premna microphylla Turez 15-25, small
HERBA ONYCHII grass 10-15, Sculellaria barbata 15-30, Radix Polygalae 10-15, phoenix-tail fern 15-30, spina date seed 10-30, ganoderma lucidum 4-9, cordyceps sinensis
3-9 and mock-strawberry 15-30.
Each raw material effect in above-mentioned formula is as follows：
Premna microphylla Turez [pharmacological property] is salty pungent, cold.Channel tropism《Fujian east book on Chinese herbal medicine》：Enter liver, courage two passes through.It is nontoxic.[effect] is clearing heat and detoxicating, disappears
The swollen scattered stasis of blood.It cures mainly：Venomous snake bite, children Liang wind, stomatitis, furuncle, carbuncle, urinary tract infections, tympanitis, rheumatic arthritis etc..
Small pheasant tail grass [pharmacological property] is bitter, cold.The thoughts of returning home, liver, lung, stomach, small intestine, large intestine channel.[effect] clearing heat and detoxicating, dampness removing,
Hemostasis.Main anemopyretic cold, pharyngalgia, diarrhea, dysentery, urine leaching pain, jaundice with damp-heat pathogen, haematemesis, hemoptysis, is had blood in stool, hemorrhoid blood, urine at cough
Blood, sore, traumatic injury, venomous snake bite, burn and scald.
Ganoderma lucidum [pharmacological property] is sweet in flavor, warm-natured.The thoughts of returning home, spleen, kidney, the spleen channel.[effect] there is anti-cancer and cancer-preventing, liver detoxification to drop blood
Sugared function.Mainly improve cardiovascular and cerebrovascular, to insufficiency of vital energy and blood, neurasthenia, promote longevity, improve immunity, improve sleep, easypro
Muscle is active, has a delicate constitution.
Cordyceps sinensis [pharmacological property] returns kidney, lung channel.[effect] there is empty tonifying lung, kidney tonifying, adjusting liver, supporing yang, raising to be immunized
Power and other effects.
Sculellaria barbata [pharmacological property] acrid flavour, slight bitter, cold nature.Return lung, liver and kidney channel.[effect] is clearing heat and detoxicating, detumescence is stopped blooding, profit
Water is subsided a swelling, applied to caused by heat toxin carbuncle swells, furunculosis, venomous snake bite, stagnant heat haematemesis, ascites, oedema, be now usually used in it is a variety of swollen
Tumor.
It is the sour micro-pungent of Radix Polygalae [pharmacological property], mild-natured.The channel tropism heart, liver, spleen.[effect] tranquilize the mind and promote the intelligence, eliminating the phlegm have one's ideas straightened out, dissipation carbuncle
It is swollen, for tranquilize the mind and promote the intelligence, carbuncle swells, swollen ulcer drug etc..
Phoenix-tail fern [pharmacological property] bitter is trembled with fear.Channel tropism liver, stomach, lung, great Yang, bladder warp.[effect] removing damp-heat, cooling blood and hemostasis,
Subdhing swelling and detoxicating；Control U dog bites, phosphorus decomposing, opium, arsenic poisoning.
Spina date seed [pharmacological property] is mild-natured, sweet in flavor.[effect] arrest sweating, nourishing the liver.Control polydipsia, abnormal sweating, dysphoria, palpitation with fear palpitation etc..
Mock-strawberry [pharmacological property] is sweet in flavor, sour, cold in nature slightly poisonous.Channel tropism lung, stomach, liver.[effect] clearing heat and detoxicating, cooling blood and hemostasis, uses
In high fever frightened epilepsy, abscess of throat, carbuncle swells, furunculosis, erysipelas, venomous snake bite, herba fibraureae recisae, arsenic poisoning etc..
In above-mentioned formula, Premna microphylla Turez, small pheasant tail grass, Sculellaria barbata, mock-strawberry, phoenix-tail fern are the key medicine for solving a variety of Ai, together
When the effect of also acting as heat-clearing, eliminating stasis to subdue swelling, anti-inflammatory etc.；Spina date seed is with pleasant the effect of relieving pain also with eliminating stasis to subdue swelling；Far
Will have it is calm, calm the nerves and stronger anti-Liang faints effect.Each component with the use of play tranquilizing the mind relieving restlessness, it is pleasant analgesic, diuresis dissipate
The effect of malicious block up, dispelling toxicity, detoxicating, for Ai in venomous snake bite, herba fibraureae recisae, phosphorus arsenic, poisonous fungus.Itself is free of anesthetic composition, and long term usage is not
It will produce dependence.Taking the breaking-out of 20 minutes or so drug addiction, symptoms start to alleviate, and even served 4-6 days patients can be from mentally breaking away from
The temptation of drugs.It is understood that above-mentioned each raw material combines each raw material dosage that can effectively play said effect.
In a preferred embodiment, which is made of the raw material of following parts by weight：Premna microphylla Turez 20-25, small pheasant
Tail grass 10-15, Sculellaria barbata 20-30, Radix Polygalae 10-15, phoenix-tail fern 20-30, spina date seed 15-30, ganoderma lucidum 6-9, cordyceps sinensis 5-9 and
Mock-strawberry 20-30.
Effect is given up to opioid drug in order to verify the pharmaceutical formulation that the embodiment of the present invention is provided, carries out following medicines
Object toxicity test and pharmacodynamics test, to illustrate that the drug itself has no toxic side effect, and the withrawal symptom tool of morphine addicted rabbit
There is the alleviation suppression therapy improvement result of highly significant.
Embodiment 1
By picking of raw material decontamination, clean, dry after, in parts by weight, by 15 parts of Premna microphylla Turez, 10 parts of small pheasant tail grass,
15 parts of 15 parts of Sculellaria barbata, 10 parts of Radix Polygalae, 15 parts of phoenix-tail fern, 10 parts of spina date seed, 4 parts of ganoderma lucidum, 3 parts of cordyceps sinensis and mock-strawberry mixtures,
It is packed after crushing；
Weather and temperature variations is combined to impregnate 1- in sterile chamber sacked material and the sterile purified water of 8 times of weight
5 days；
Soak is put into togerther first intense fire in container with the sacked material impregnated to boil, then slow boiling is kept for 30-60 points
Clock obtains lysate, filtering, and the bottling of filtrate high temperature sterilization is made.
Embodiment 2
By picking of raw material decontamination, clean, dry after, in parts by weight, by 20 parts of Premna microphylla Turez, 10 parts of small pheasant tail grass,
20 parts of 20 parts of Sculellaria barbata, 10 parts of Radix Polygalae, 20 parts of phoenix-tail fern, 15 parts of spina date seed, 6 parts of ganoderma lucidum, 5 parts of cordyceps sinensis and mock-strawberry mixtures,
It is packed after crushing；
Weather and temperature variations is combined to impregnate 1- in sterile chamber sacked material and the sterile purified water of 8 times of weight
5 days；
Soak is put into togerther first intense fire in container with the sacked material impregnated to boil, then slow boiling is kept for 30-60 points
Clock obtains lysate, filtering, and the bottling of filtrate high temperature sterilization is made.
Embodiment 3
By picking of raw material decontamination, clean, dry after, in parts by weight, by 25 parts of Premna microphylla Turez, 15 parts of small pheasant tail grass,
30 parts of 30 parts of Sculellaria barbata, 15 parts of Radix Polygalae, 30 parts of phoenix-tail fern, 30 parts of spina date seed, 9 parts of ganoderma lucidum, 9 parts of cordyceps sinensis and mock-strawberry mixtures,
It is packed after crushing；
Weather and temperature variations is combined to impregnate 1- in sterile chamber sacked material and the sterile purified water of 8 times of weight
5 days；
Soak is put into togerther first intense fire in container with the sacked material impregnated to boil, then slow boiling is kept for 30-60 points
Clock obtains lysate, filtering, and the bottling of filtrate high temperature sterilization is made.
Embodiment 4
By picking of raw material decontamination, clean, dry after, in parts by weight, by 20 parts of Premna microphylla Turez, 10 parts of small pheasant tail grass,
20 parts of 20 parts of Sculellaria barbata, 10 parts of Radix Polygalae, 20 parts of phoenix-tail fern, 15 parts of spina date seed, 6 parts of ganoderma lucidum, 5 parts of cordyceps sinensis and mock-strawberry mixtures,
It is packed after crushing；
Weather and temperature variations is combined to impregnate 1- in sterile chamber sacked material and the sterile purified water of 8 times of weight
5 days；
Soak is put into togerther first intense fire in container with the sacked material impregnated to boil, then slow boiling is kept for 30-60 points
Clock obtains lysate, filtering, filtrate is condensed into thick paste, dry, crushing, then be incorporated appropriate medical accessory, is packed into capsule later
Drug-dropping capsule is made.
Embodiment 5
By picking of raw material decontamination, clean, dry after, in parts by weight, by 25 parts of Premna microphylla Turez, 15 parts of small pheasant tail grass,
30 parts of 30 parts of Sculellaria barbata, 15 parts of Radix Polygalae, 30 parts of phoenix-tail fern, 30 parts of spina date seed, 9 parts of ganoderma lucidum, 9 parts of cordyceps sinensis and mock-strawberry mixtures,
It is packed after crushing；
Weather and temperature variations is combined to impregnate 1- in sterile chamber sacked material and the sterile purified water of 8 times of weight
5 days；
Soak is put into togerther first intense fire in container with the sacked material impregnated to boil, then slow boiling is kept for 30-60 points
Clock obtains lysate, filtering, filtrate is condensed into thick paste, dry, crushing, then be incorporated appropriate medical accessory and tablet, pill is made
Or electuary or other pharmaceutically acceptable dosage forms.
Toxicity trial
The acute experiment of high dose rabbit gastric infusion is carried out to drug of the present invention, 1h animal activities subtract after each dosage group
It is few, peace and quiet, but exaggerated respiration are shown, 3h restores rest state, occurs without death rabbit.Later continuous use 5 days, daily
Observation 3 times, general physical signs, behavioral activity, the state of mind, the animal survival no abnormality seen phenomenon of animal subject.Wherein one
All smoothly produce lower rabbit son within more than ten days after 2 pregnant rabbits of group are tested, and without there are deformity and the phenomena of mortality.Other test rabbits
They were put to death in 7th day, the major organs no abnormality seen such as its heart, liver, spleen, lung, stomach, kidney, intestines, brain, rabbit are visually observed after dissection
Sub- heart has no that blutpunkte, the intact each organs and tissues no exceptions of stomach mucosa change.In summary long term toxicity test table
Bright, which can effectively control acute withdrawal symptom, and curative effect affirmative is used alone in this medicine, safe, does not find malicious pair
Effect.
Pharmacodynamics test
Method：Rabbit is established using gradually increment hair, the animal experiment relied on is generated to morphine.Observe medicine oral liquid pair
There is the therapeutic effect of typical withrawal symptom in morphine animal after morphine receptor antagonist-naloxone urges addiction.The result shows that should
Drug has specific drug abstinence to opium drug habituation, has the characteristics that rapid-action, effect is strong, moreover, the drug sheet
Body is not belonging to m orphine addictive drug, drug safety, and long term usage not will produce dependence.
Specifically, this experiment uses the gradual incremental method of morphine administration dosage, hydrochloric acid is injected intraperitoneally to experiment rabbit in 2 days
Injection of morphia liquid 6 times forms the animal of Syndrome of Morphine Dependent.Then giving morphine receptor antagonist-naloxone urges addiction, can make
There is hopping response, the typical withrawal symptom of the substantially reduced equal addictive drugs of constitution in coffee dependent form rabbit.Pass through the drug pair
The influence for the withrawal symptom that morphine type rabbit generates after urging addiction with naloxone, observe the anti-opium drug of the drug at
Addiction acts on.
Animal：Rabbit 1kg/5,1.5kg/5 are only, only (two pregnant rabbits) is divided into three groups to 2.5kg/5.Rabbit is given in two days
Son injects morphine hydrochloride injection 4 times (respectively at 9:00、11:00、13:00、15:00) dosage be sequentially incremented by 8mg/kg,
16mg/kg、25mg/kg、50mg/kg.Each group animal injection-naloxone is urged and being jumped in 20 minutes after addiction, administration group
Number of skips is significantly reduced compared with morphine group, and there is the inhibiting effect of morphine addicted rabbit hopping response preferable amount-effect to close
System.Show that the drug has calm and stable effect.This shows that anxious, mood is irritated, quiet when breaking out patient's drug addiction
Only the symptoms such as difficulty have ideal inhibiting effect.Especially morphine group animal rabbit urges addiction 4h, 8h, 12h, animal body in naloxone
It more decreased significantly with before urging addiction again, especially 6h weight loss is the most apparent after naloxone urges addiction；Remaining each animal body
Though weight has downward trend compared with being urged before addiction with naloxone, without significant difference.Test result shows the drug morphine addicted rabbit
Withrawal symptom there is apparent treatment improvement result, and the quick recovery of its body can be promoted.Each group animal experiment first time,
Second of naloxone urges the withrawal symptom occurred after addiction to find out, morphine rabbit is after naloxone urges addiction, the table of withrawal symptom
It is now the most serious.And the withrawal symptom of medicine group is significantly lower than morphine group, illustrates the withrawal symptom of the drug morphine addicted rabbit
Alleviation suppression therapy improvement result with highly significant.
To further demonstrate that the curative effect of the present invention, 307 hospitals of commission guard against the application formula treatment opiates addiction
The effect of disconnected syndrome, has carried out clinical observation, specific as follows：
Observation index is respectively：Methadone dosage during treatment, Allylnoroxymorphone challenge test (voluntary) result after treatment.
For the ease of comparing, transfer what the same period quit drug abuse, gas absorption dosage is formulated treatment group patient similar 12 with the application is taken
The conventional clinical data taken methadone and substitute the patient that successively decreases of example, observation and comparison result are as follows：
1. case selection：
14 Opioid dependence patients, man 10, woman 4, the age is 23 years old minimum, 47 years old maximum, average
32.15 years old.Average daily gas absorption dosage is 0.64g, and the time of taking drugs is 7.02, previously minimum drug rehabilitation 1 time, at most quits drug abuse 40
It is secondary.All patients meet opiates addiction standard, voluntarily receive the application formula group and treat and endorsed informed consent
Book.
The same period is hospitalized, the conventional patient for using methadone step-down therapy, selects its gas absorption dosage and is treated with the application formula group
The similar person of group patient in group, observes object as a contrast, totally 12, and man 9, woman 3, the age is 25 years old minimum, maximum 47
It is year, 35.59 years old average.Average daily gas absorption dosage is 0.62g, and the time of taking drugs is 7 years, and previously minimum drug rehabilitation 1 time, at most quits drug abuse
22 times.All patients meet opiates addiction standard.Refer to table one, table two.
One ordinary circumstance of table
Table two uses drugs situation
2. therapy and curative effect determinate standard
2.1 therapy：
2.1.1 the application is formulated treatment group：It is admitted to hospital and signs to start after informed consent form to give the application formula group and control
It treats, the application formula group 100ml 12h/ times, continuously takes 4-5 days, and treatment end carries out Allylnoroxymorphone according to patient personal inclination
Challenge test, challenge test negative patient give the treatment of naltrexone preventing suction again.When withrawal symptom control it is bad, add the application and match
Side group 50ml.Withrawal symptom still without improver, can give methadone and take orally, to ensure the treatment of the basic no pain drug rehabilitation of patient
Effect.All medications are required to strictly record.
The application is formulated treatment group patient and forward and backward detects index giving the treatment of the application formula group：1 serum opium
Substance is quantitative, 2 hepatic and renal functions, 3 blood, routine urinalysis, and 4 urine morphine detections are carried out before medication, after medication after 72h, treatment end,
5 withrawal symptom scales, evaluation is primary daily for craving intensity ratings.
2.1.2 methadone step-down therapy group：It is admitted to hospital and gives conventional methadone according to patient's drug abuse amount and substitute step-down therapy.
Record all medications.
2.2 efficacy determination：
2.2.1 leading indicator：
2.2.1.1 it quits drug abuse success rate：It is negative that morphine detection is urinated when treatment end, Allylnoroxymorphone challenge test feminine gender.Refer to table
Three.
Table three urinates morphine detection and Allylnoroxymorphone challenge test inventory
2.2.1.2 methadone dosage：With cethadone treatment group ratio, it is invalid that methadone dosage is equal therewith；
It is effective that dosage, which reduces 50%,；It is effective that dosage, which is reduced to 80% or more,.
3 results
Drug rehabilitation success rate：
Exit 2 in 14,1 because of intolerable gastrointestinal reaction, 1 controls bad for withrawal symptom, recalls and knows
Feelings letter of consent.12 completion clinical observations, urine morphine detection 72h negative rates reach 80% (8/10), are 100% after treatment.8
It is feminine gender voluntarily to receive Allylnoroxymorphone challenge test person.Allylnoroxymorphone challenge test success rate 100%, general comment drug rehabilitation success rate are
85.71%.It can be seen that this formula has specific drug abstinence to opium drug habituation, there is rapid-action, effect is strong etc.
Feature, and this formula itself is not belonging to m orphine addictive drug, drug safety, long term usage not will produce dependence.
Claims (4)
1. a kind of anti-additive medicament, which is characterized in that be made of the raw material of following parts by weight：
Premna microphylla Turez 15-25, small pheasant tail grass 10-15, Sculellaria barbata 15-30, Radix Polygalae 10-15, phoenix-tail fern 15-30, spina date seed 10-
30, ganoderma lucidum 4-9, cordyceps sinensis 3-9 and mock-strawberry 15-30.
2. anti-additive medicament according to claim 1, which is characterized in that be made of the bulk pharmaceutical chemicals of following parts by weight：
Premna microphylla Turez 20-25, small pheasant tail grass 10-15, Sculellaria barbata 20-30, Radix Polygalae 10-15, phoenix-tail fern 20-30, spina date seed 15-
30, ganoderma lucidum 6-9, cordyceps sinensis 5-9 and mock-strawberry 20-30.
3. the preparation method of anti-additive medicament according to claim 1 or 2, which is characterized in that include the following steps：
By picking of raw material decontamination, clean, dry after, according to parts by weight mixture, packed after crushing；
The sterile purified water of sacked material and 8-20 times of weight is impregnated 1-5 days in sterile chamber；
Soak is put into togerther first intense fire in container with the sacked material impregnated to boil, then slow boiling is kept for 30-60 minutes, is obtained
To lysate, the bottling of filtrate high temperature sterilization is made for filtering.
4. the preparation method of anti-additive medicament according to claim 1 or 2, which is characterized in that include the following steps：
By picking of raw material decontamination, clean, dry after, according to parts by weight mixture, packed after crushing；
The sterile purified water of sacked material and 8-20 times of weight is impregnated 1-5 days in sterile chamber；
Soak is put into togerther first intense fire in container with the sacked material impregnated to boil, then slow boiling is kept for 30-60 minutes, is obtained
To lysate, filtrate is condensed into thick paste by filtering, dry, crush, then is incorporated appropriate medical accessory and be can be made into and can pharmaceutically connect
Any dosage form received.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810812066.9A CN108553528A (en) | 2018-07-23 | 2018-07-23 | Anti-additive medicament and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810812066.9A CN108553528A (en) | 2018-07-23 | 2018-07-23 | Anti-additive medicament and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108553528A true CN108553528A (en) | 2018-09-21 |
Family
ID=63555868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810812066.9A Pending CN108553528A (en) | 2018-07-23 | 2018-07-23 | Anti-additive medicament and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108553528A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1195539A (en) * | 1997-04-07 | 1998-10-14 | 夏小平 | Narcotics-giving up medicine made from pure Chinese medicinal herbs |
| CN1359679A (en) * | 2001-12-24 | 2002-07-24 | 中国人民解放军第一军医大学 | Medicine for dropping off drug and its preparing process |
| CN1513509A (en) * | 2003-07-17 | 2004-07-21 | 童亚林 | Formula of chinese herbal medicine composition for whole life abstaining drug habit |
| CN1533789A (en) * | 2003-03-27 | 2004-10-06 | 姚建设 | Medicine for giving up toxin and its preparation method |
| CN1593486A (en) * | 2004-06-23 | 2005-03-16 | 吉林天药科技有限公司 | Pharmaceutical composition for stopping drug addiction and its preparing process |
-
2018
- 2018-07-23 CN CN201810812066.9A patent/CN108553528A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1195539A (en) * | 1997-04-07 | 1998-10-14 | 夏小平 | Narcotics-giving up medicine made from pure Chinese medicinal herbs |
| CN1359679A (en) * | 2001-12-24 | 2002-07-24 | 中国人民解放军第一军医大学 | Medicine for dropping off drug and its preparing process |
| CN1533789A (en) * | 2003-03-27 | 2004-10-06 | 姚建设 | Medicine for giving up toxin and its preparation method |
| CN1513509A (en) * | 2003-07-17 | 2004-07-21 | 童亚林 | Formula of chinese herbal medicine composition for whole life abstaining drug habit |
| CN1593486A (en) * | 2004-06-23 | 2005-03-16 | 吉林天药科技有限公司 | Pharmaceutical composition for stopping drug addiction and its preparing process |
Non-Patent Citations (1)
| Title |
|---|
| STEVEN D. PASSIK等: "Psychiatric and Pain Characteristics of Prescription Drug Abusers Entering Drug Rehabilitation", 《JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103099959B (en) | Traditional Chinese medicine preparation for treating ulcerative colitis and preparation method thereof | |
| CN100998843A (en) | Medicinal composition for treating cholecystitis | |
| CN101732558A (en) | Traditional Chinese medicine granules used for treating chronic pharyngitis | |
| CN102772781B (en) | Traditional Chinese medicine preparation for treating chronic colitis and preparation method thereof | |
| CN103405697A (en) | Medicament for treating pulmonary tuberculosis | |
| CN100409883C (en) | Chinese medicinal composition for treating agrypnia, functional gastricism and astriction and its preparation method | |
| CN103520505A (en) | Traditional Chinese medicine preparation for treating neurasthenia and preparation method thereof | |
| CN101732500A (en) | Medicine for preventing and treating acute and chronic pharyngitis and sphagitis | |
| CN108553528A (en) | Anti-additive medicament and preparation method thereof | |
| CN103007145B (en) | Traditional Chinese medicine composition for treating children rotavirus enteritis and preparation method of composition | |
| CN102940677B (en) | Medicine composition for treating diabetic foot | |
| CN102861289B (en) | Chinese medicinal drug addiction stopping and three-hyper lowering capsule | |
| CN102552841B (en) | Traditional Chinese medicine for treating apoplexy sequelae | |
| CN107137504B (en) | Health food for improving sleep and enhancing immunity | |
| CN100394976C (en) | Chinese medicine for withdrawal of drug dependence | |
| CN104257803A (en) | Pharmaceutical composition for treating snore as well as preparation method and application of pharmaceutical composition | |
| CN102266426B (en) | Drug composition for drug quit | |
| CN112245435B (en) | Composition for rescuing gelsemium intoxication and application thereof | |
| CN107737259A (en) | A kind of Chinese prescription for improving male's sexual | |
| CN101632729A (en) | Application of Chinese medicinal composition in preparing medicament for treating involution syndrome | |
| CN100389809C (en) | Chinese medicinal composition for treating asthma, and its preparation and use | |
| CN107260749B (en) | Drug, pharmaceutical composition and the application for treating sleep apnea syndrome | |
| CN105031499A (en) | Traditional Chinese medicine composition for treating duodenal ulcer | |
| CN103127301A (en) | Traditional Chinese medicine transdermal absorption administration carrier, traditional Chinese medicine clothes, and medicine clothes with disease control effect | |
| CN104189610A (en) | Traditional Chinese medicine composition for treating bronchitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180921 |