CN108543108B - Common sterilization sponge for anesthesia department - Google Patents
Common sterilization sponge for anesthesia department Download PDFInfo
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- CN108543108B CN108543108B CN201810409754.0A CN201810409754A CN108543108B CN 108543108 B CN108543108 B CN 108543108B CN 201810409754 A CN201810409754 A CN 201810409754A CN 108543108 B CN108543108 B CN 108543108B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/07—Aldehydes; Ketones
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/16—Nitrogen-containing compounds
- C08K5/34—Heterocyclic compounds having nitrogen in the ring
- C08K5/3467—Heterocyclic compounds having nitrogen in the ring having more than two nitrogen atoms in the ring
- C08K5/3477—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/202—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with halogen atoms, e.g. triclosan, povidone-iodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention discloses a commonly-used sterilization and disinfection sponge for anesthesia department, which is prepared by the following steps: (1) preparing a polyvinyl alcohol solution; (2) adding chitosan powder and a foaming agent into the polyvinyl alcohol solution; (3) adding a pH regulator into the mixed solution obtained in the step (2) to keep the pH value of the mixed solution at 6-8; (4) adding a cross-linking agent, stirring, adding a sterilization modifier, continuously stirring, and taking out a product; (5) pouring the product taken out in the step (4) into a mold box, and baking and forming; (6) and (5) taking out the product formed in the step (5), washing with distilled water or deionized water, and airing to obtain the common sterilizing sponge for the anesthesia department. The sponge provided by the invention has the advantages of high hemostatic effect, high sterilization and disinfection effect, low equipment requirement, reasonable and simple operation, and easy popularization, and the prepared sponge can be directly used for medical treatment.
Description
Technical Field
The invention relates to the technical field of medical sponges, in particular to a commonly-used sterilization and disinfection sponge for an anesthesia department.
Background
The artificial sponge is also called synthetic sponge. The artificial sponge is prepared by utilizing polymers to mutually generate polymerization reaction, simultaneously adding different additives and foaming agents, and finally drying. The sponge has different application ranges due to different raw materials and proportions. The artificial sponge not only has a porous structure of natural sponge, but also has the characteristics of heat preservation, high elasticity and the like. The existing artificial sponge generally refers to polyurethane soft foamed rubber, is a chemical product, has a primary color of off-white, but is oxidized in the air for a long time to become yellow, and the color of the sponge is a result of manual selective control and continuously changes according to the requirements of people. In production, with the continuous improvement of requirements of people on different types and purposes of sponges, sponges with various shapes can be prepared by utilizing different molds.
Artificial sponges can be classified into many types according to the raw materials, elasticity, use and density of the preparation. The raw materials for preparing the artificial sponge are mainly divided into polyurethane and polyvinyl alcohol; the sponge can be divided into slow elastic sponge, common sponge and high elastic sponge according to the elasticity of the sponge; according to different purposes of the sponge, the sponge can be divided into a hardened sponge, a flame-retardant sponge, an antistatic sponge and the like; artificial sponges with closely differing structures can be classified as low density sponges and high density sponges. The sponge has wide application in daily life, determines the difference of sponge shape, color and performance, can select proper raw materials and additives in the preparation process to prepare artificial sponges with different performances in order to meet various requirements of practical application, and further meets the requirements of people on various performances of the sponge.
The existing common sponge for anesthesia department mainly has the following problems: (1) the water absorption rate is low, so that the hemostasis speed is low; (2) the sterilization and disinfection effect is poor, the good cure effect on human bodies is not promoted in the actual use process, and certain limitation exists in the use.
Therefore, the invention provides a commonly-used sterilization and disinfection sponge for anesthesia department to solve the problems.
Disclosure of Invention
The invention aims to solve the technical problems of low hemostasis speed and poor sterilization and disinfection effects of common sponges used in the anesthesia department in the prior art, and provides a common sterilization and disinfection sponge used in the anesthesia department.
A commonly-used sterilization and disinfection sponge for anesthesia department is prepared by the following steps:
(1) preparing a polyvinyl alcohol solution with the concentration of 20-25%;
(2) adding chitosan powder and a foaming agent into the polyvinyl alcohol solution, and stirring for 40-60 min to obtain a mixed solution; the addition amount of the chitosan powder is 30-40 wt% of the polyvinyl alcohol solution; the addition amount of the foaming agent is 5-10 wt% of the polyvinyl alcohol solution;
(3) adding a pH regulator into the mixed solution obtained in the step (2) to keep the pH value of the mixed solution at 6-8, stirring, and keeping the temperature stable at 40-45 ℃;
(4) adding a cross-linking agent, stirring for 40-60 min, adding a sterilization modifier, continuously stirring for 40-60 min, and taking out a product; the cross-linking agent consists of hexamethylenetetramine and glyoxal, wherein the weight ratio of the hexamethylenetetramine to the glyoxal is 1: 4-6; the addition amount of the cross-linking agent is 10-15 wt% of the polyvinyl alcohol solution; the addition amount of the modified bactericide is 10-15 wt% of the polyvinyl alcohol solution;
(5) pouring the product taken out in the step (4) into a mold box, and baking and forming;
(6) and (5) taking out the product formed in the step (5), washing with distilled water or deionized water, and airing to obtain the common sterilizing sponge for the anesthesia department.
Preferably, the sterilization modifier in the step (4) is composed of povidone iodine and a compound (I), wherein the weight ratio of the povidone iodine to the compound (I) is 1:3, and the structural formula of the compound (I) is as follows:
preferably, the baking temperature in step (5) is 50-70 ℃.
Preferably, the stirring time in the step (3) is 20-30 min.
Preferably, the pH regulator in step (3) is one of hydrochloric acid, sulfuric acid, sodium hydroxide and potassium hydroxide.
Preferably, the foaming agent in the step (2) is one or more of tween-80, tween-60, tween-40 and tween-20.
The common sterilizing sponge for the anesthesia department provided by the invention has the following technical effects:
(1) the cross-linking agent consists of hexamethylenetetramine and glyoxal, and a large number of experiments verify that the optimal dosage of the cross-linking agent and the proportion of the hexamethylenetetramine and the glyoxal in the cross-linking agent are finally determined, so that the water absorption of the sponge achieves the optimal performance. If the amount of the cross-linking agent or the ratio of the components in the cross-linking agent is improperly controlled, the cross-linking is too weak or excessive, so that the water absorption of the sponge is reduced, and the hemostasis speed is affected.
(2) By adding the sterilization modified liquid and reasonably controlling the weight ratio of the povidone iodine to the compound (I) in the sterilization modified liquid, the sterilization and disinfection effects of the sponge are obviously improved, and the healing effect is further improved.
(3) The preparation method provided by the invention has the advantages of low equipment requirement, reasonable and simple operation, and the prepared sponge can be directly used for medical treatment and is easy to popularize.
Drawings
FIG. 1 shows the microstructure of a sponge prepared according to the present invention under an electron microscope (SEM).
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
Example 1
A commonly-used sterilization and disinfection sponge for anesthesia department is prepared by the following steps:
(1) preparing a polyvinyl alcohol solution with the concentration of 20%;
(2) adding chitosan powder and a foaming agent into the polyvinyl alcohol solution, and stirring for 40min to obtain a mixed solution; the addition amount of the chitosan powder is 30 wt% of the polyvinyl alcohol solution; the addition amount of the foaming agent is 5 wt% of the polyvinyl alcohol solution;
(3) adding a pH regulator into the mixed solution obtained in the step (2) to keep the pH value of the mixed solution at 6, stirring, and keeping the temperature stable at 40 ℃;
(4) adding cross-linking agent, stirring for 40min, adding sterilizing modifier, stirring for 40min, and taking out the product; the cross-linking agent consists of hexamethylenetetramine and glyoxal, wherein the weight ratio of the hexamethylenetetramine to the glyoxal is 1: 4; the addition amount of the cross-linking agent is 10 wt% of the polyvinyl alcohol solution; the addition amount of the modified bactericide is 10 wt% of the polyvinyl alcohol solution;
(5) pouring the product taken out in the step (4) into a mold box, and baking and forming;
(6) and (5) taking out the product formed in the step (5), washing with distilled water or deionized water, and airing to obtain the common sterilizing sponge for the anesthesia department.
The sterilization modifier in the step (4) is composed of povidone iodine and a compound (I), wherein the weight ratio of the povidone iodine to the compound (I) is 1:3, and the structural formula of the compound (I) is as follows:
wherein the baking temperature in the step (5) is 50 ℃, the stirring time in the step (3) is 20min, the pH regulator in the step (3) is one of hydrochloric acid, sulfuric acid, sodium hydroxide and potassium hydroxide, and the foaming agent in the step (2) is tween-80.
Example 2
A commonly-used sterilization and disinfection sponge for anesthesia department is prepared by the following steps:
(1) preparing a polyvinyl alcohol solution with the concentration of 23%;
(2) adding chitosan powder and a foaming agent into the polyvinyl alcohol solution, and stirring for 50min to obtain a mixed solution; the addition amount of the chitosan powder is 35 wt% of the polyvinyl alcohol solution; the addition amount of the foaming agent is 8 wt% of the polyvinyl alcohol solution;
(3) adding a pH regulator into the mixed solution obtained in the step (2) to keep the pH value of the mixed solution at 7, stirring, and keeping the temperature stable at 43 ℃;
(4) adding cross-linking agent, stirring for 50min, adding sterilizing modifier, stirring for 50min, and taking out the product; the cross-linking agent consists of hexamethylenetetramine and glyoxal, wherein the weight ratio of the hexamethylenetetramine to the glyoxal is 1: 5; the addition amount of the cross-linking agent is 103 wt% of the polyvinyl alcohol solution; the addition amount of the modified bactericide is 13 wt% of the polyvinyl alcohol solution;
(5) pouring the product taken out in the step (4) into a mold box, and baking and forming;
(6) and (5) taking out the product formed in the step (5), washing with distilled water or deionized water, and airing to obtain the common sterilizing sponge for the anesthesia department.
The sterilization modifier in the step (4) is composed of povidone iodine and a compound (I), wherein the weight ratio of the povidone iodine to the compound (I) is 1:3, and the structural formula of the compound (I) is as follows:
wherein the baking temperature in the step (5) is 60 ℃, the stirring time in the step (3) is 25min, the pH regulator in the step (3) is one of hydrochloric acid, sulfuric acid, sodium hydroxide and potassium hydroxide, and the foaming agent in the step (2) is tween-60.
Example 3
A commonly-used sterilization and disinfection sponge for anesthesia department is prepared by the following steps:
(1) preparing a polyvinyl alcohol solution with the concentration of 25%;
(2) adding chitosan powder and a foaming agent into the polyvinyl alcohol solution, and stirring for 60min to obtain a mixed solution; the addition amount of the chitosan powder is 40 wt% of the polyvinyl alcohol solution; the addition amount of the foaming agent is 10 wt% of the polyvinyl alcohol solution;
(3) adding a pH regulator into the mixed solution obtained in the step (2) to keep the pH value of the mixed solution at 8, stirring, and keeping the temperature stable at 45 ℃;
(4) adding a cross-linking agent, stirring for 60min, adding a sterilization modifier, continuously stirring for 60min, and taking out a product; the cross-linking agent consists of hexamethylenetetramine and glyoxal, wherein the weight ratio of the hexamethylenetetramine to the glyoxal is 1: 6; the addition amount of the cross-linking agent is 15 wt% of the polyvinyl alcohol solution; the addition amount of the modified bactericide is 15 wt% of the polyvinyl alcohol solution;
(5) pouring the product taken out in the step (4) into a mold box, and baking and forming;
(6) and (5) taking out the product formed in the step (5), washing with distilled water or deionized water, and airing to obtain the common sterilizing sponge for the anesthesia department.
The sterilization modifier in the step (4) is composed of povidone iodine and a compound (I), wherein the weight ratio of the povidone iodine to the compound (I) is 1:3, and the structural formula of the compound (I) is as follows:
wherein the baking temperature in the step (5) is 70 ℃, the stirring time in the step (3) is 30min, the pH regulator in the step (3) is one of hydrochloric acid, sulfuric acid, sodium hydroxide and potassium hydroxide, and the foaming agent in the step (2) is tween-40.
Comparative examples 1 to 8
Comparative examples 1 to 8 only changed the pH of the mixed solution in example 2, the weight ratio of hexamethylenetetramine and glyoxal, and the weight ratio of povidone-iodine and compound (I), and other parameters were the same as in example 2.
The parameter changes of examples 1 to 3 and comparative examples 1 to 8 are shown in Table 1.
TABLE 1
| Numbering | pH of the mixture | Hexamethylenetetramine: glyoxal | Povidone iodine: compound (I) |
| Example 1 | 6 | 1:4 | 1:3 |
| Example 2 | 7 | 1:5 | 1:3 |
| Example 3 | 8 | 1:6 | 1:3 |
| Comparative example 1 | 5 | 1:5 | 1:3 |
| Comparative example 2 | 9 | 1:5 | 1:3 |
| Comparative example 3 | 7 | With addition of hexamethylenetetramine only | 1:3 |
| Comparative example 4 | 7 | Addition of glyoxal only | 1:3 |
| Comparative example 5 | 7 | 1:3 | 1:3 |
| Comparative example 6 | 7 | 1:7 | 1:3 |
| Comparative example 7 | 7 | 1:5 | 1:2 |
| Comparative example 8 | 7 | 1:5 | 1:4 |
The technical effect of the invention is represented by the water absorption performance and the sterilization performance, and the specific determination method comprises the following steps:
and (3) water absorption performance measurement: weighing hemostatic sponge with certain specification and size on an analytical balance, and recording as m0. Putting the powder into distilled water, taking out the powder after the powder fully absorbs water, naturally draining the water, weighing the powder, and recording the mass as mt(for very soluble hemostatic sponge, after it fully absorbs water, pour out the distilled water, called hemostatic sponge quality). The water absorption is ((m)t–m0)/m0)×100％。
And (3) sterilization performance determination: the test uses staphylococcus aureus, and the prepared sponge is cut into pieces and placed in the center of a culture dish after inoculation, and is placed in an incubator for one day under the same conditions. Observing the shape change of the sponge, and evaluating the antibacterial performance of the sponge according to the diameter of the bacteriostatic ring.
The results of the water absorption property measurement and the bactericidal property measurement of examples 1 to 3 and comparative examples 1 to 8 are shown in table 2.
TABLE 2
In the above table, "-" indicates that the property was not detected.
As can be seen from table 2: (1) the sponge has the best cross-linking agent composition, so that the water absorption of the sponge achieves the best performance. If the dosage of the cross-linking agent or the proportion of the components in the cross-linking agent is improperly controlled, the cross-linking is too weak or excessive, so that the water absorption of the sponge is reduced, and the hemostasis speed is influenced; (2) by adding the sterilization modified liquid and reasonably controlling the weight ratio of the povidone iodine to the compound (I) in the sterilization modified liquid, the sterilization and disinfection effects of the sponge are obviously improved, and the healing effect is further improved.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (5)
1. A sterilization and disinfection sponge commonly used in anesthesia department is characterized in that the preparation process of the sponge comprises the following steps:
(1) preparing a polyvinyl alcohol solution with the concentration of 20-25%;
(2) adding chitosan powder and a foaming agent into the polyvinyl alcohol solution, and stirring for 40-60 min to obtain a mixed solution; the addition amount of the chitosan powder is 30-40 wt% of the polyvinyl alcohol solution; the addition amount of the foaming agent is 5-10 wt% of the polyvinyl alcohol solution;
(3) adding a pH regulator into the mixed solution obtained in the step (2) to keep the pH value of the mixed solution at 6-8, stirring, and keeping the temperature stable at 40-45 ℃;
(4) adding a cross-linking agent, stirring for 40-60 min, adding a sterilization modifier, continuously stirring for 40-60 min, and taking out a product; the cross-linking agent consists of hexamethylenetetramine and glyoxal, wherein the weight ratio of the hexamethylenetetramine to the glyoxal is 1: 4-6; the addition amount of the cross-linking agent is 10-15 wt% of the polyvinyl alcohol solution; the addition amount of the modified bactericide is 10-15 wt% of the polyvinyl alcohol solution;
(5) pouring the product taken out in the step (4) into a mold box, and baking and forming;
(6) taking out the product formed in the step (5), washing with distilled water or deionized water, and airing to obtain the common sterilizing sponge for the anesthesia department;
the sterilization modifier in the step (4) consists of povidone iodine and a compound (I), wherein the weight ratio of the povidone iodine to the compound (I) is 1:3, and the structural formula of the compound (I) is as follows:
2. the sterilization and disinfection sponge for general anesthesia department as claimed in claim 1, wherein the baking temperature in the step (5) is 50-70 ℃.
3. The sterilization and disinfection sponge for general use in anesthesia department according to claim 1, wherein the stirring time in the step (3) is 20-30 min.
4. The sterilization and disinfection sponge for general use in anesthesia department as claimed in claim 1, wherein the pH regulator in step (3) is one of hydrochloric acid, sulfuric acid, sodium hydroxide and potassium hydroxide.
5. The sterilization and disinfection sponge for general use in anesthesia department according to claim 1, wherein the foaming agent in step (2) is one or more of tween-80, tween-60, tween-40 and tween-20.
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