CN105251034A - Novel self-expanding composite material with hemostatic and anti-infectious effects and preparation method - Google Patents
Novel self-expanding composite material with hemostatic and anti-infectious effects and preparation method Download PDFInfo
- Publication number
- CN105251034A CN105251034A CN201510762697.0A CN201510762697A CN105251034A CN 105251034 A CN105251034 A CN 105251034A CN 201510762697 A CN201510762697 A CN 201510762697A CN 105251034 A CN105251034 A CN 105251034A
- Authority
- CN
- China
- Prior art keywords
- composite
- infective
- novel self
- stirring
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention discloses a novel self-expanding composite material with the hemostatic and anti-infectious effects and a preparation method. The composite material is prepared from polyvinyl alcohol, an anti-bacterial agent, a cross-linking agent, acid and a foaming agent. The polyvinyl alcohol, the anti-bacterial agent, the cross-linking agent, the acid and the foaming agent are subjected to condensation polymerization in an aqueous solution, a condensation polymer is dried and cut into slices, and the slices are compounded with a semipermeable membrane to obtain the wound composite material. According to the prepared composite material, by adding the semipermeable membrane, the permeability can be reduced to prevent dehydration of a wound, and the composite material is prevented from easily adhering to the wound to prevent secondary mechanical injury to the wound; meanwhile, by using the semipermeable membrane, external microorganisms can not pass easily, and then silver ions can penetrate through the semipermeable membrane to sterilize and disinfect the wound. In this way, the composite material is more effective in use, replacement frequency is reduced, and usage amount is reduced.
Description
Technical field
The present invention relates to medical material tech field, relate to a kind of hemostasis, the novel self-expanding composite of anti-infective and preparation method in particular.
Technical background
Polyvinyl alcohol foam sponge is owing to possessing excellent water absorption, and after water suction, quality is soft and have heat-resisting, wearability preferably, therefore can be applicable to filtering material, sound insulation and heat-barrier material, cleaning wiping cloth and medical material etc.; When sponge uses as medical material, especially with easy infection or infected wound contacts time, just not only require that there is good water absorption, and material also should possess antibiotic property.
Medical dressing refers to the covering covering and have protective effect on wound, can assist Bleeding control, protects from infection and absorb secretions.Modern medical bio bressing is the Novel wound reparation and protective material that grow up in repair in trauma " moistening healing " theoretical basis of Winter and Hinman etc.; compared with traditional medical dressing (as defat cotton yarn), modern medical bio bressing has acceleration wound healing, avoids wound surface adhesion, promotes the feature such as tissue repair, anti-inflammation.In burn treating, the antiseptic dressing containing antibacterials is used to be still one of important measures of prevention wound surface generation invasive infection.Good antiseptic dressing must possess penetrate eschar ability, broad-spectrum antiseptic, not easily produce drug resistance, without local irritation, characteristic without systemic adverse reactions.
But these antiseptic dressings have obvious defect.Such as: permeability is too high, wound surface is dewatered; Adhesion wound surface, more produces mechanical injuries again during change dressings; External microbe easily passes through cross infection; Consumption is many, changes frequent, time-consuming and make patient suffering.
Therefore, be necessary to propose a kind of technical scheme, permeability can be reduced and avoid wound surface to dewater, and wound surface of not easily adhering again mechanical injuries can not occur, external microbe not easily passs through simultaneously, decreases replacing now, reduce consumption, become a kind of new technical need.
Summary of the invention
(1) technical problem that will solve
For above shortcoming, the present invention proposes a kind of technical scheme, be specially a kind of hemostasis, the novel self-expanding composite of anti-infective, can reduce permeability avoids wound surface to dewater, and wound surface of not easily adhering again mechanical injuries can not occur, external microbe not easily passs through simultaneously, decreases replacing now, reduce consumption, become a kind of new technical need.
(2) technical scheme
For solving the problems of the technologies described above, the invention provides described one hemostasis, the novel self-expanding composite of anti-infective, described composite comprises polyvinyl alcohol, antibacterial, cross-linking agent, acid and foaming agent, and the quality of described component than percentage by volume is:
By polyvinyl alcohol, antibacterial, cross-linking agent, acid and foaming agent in aqueous polycondensation reaction form, condensation polymer drying is cut in flakes, obtains wound surface composite with semipermeable membrane compound.
Further, the nanometer silver in described composite is adsorbed in sponge structure, is 0.01-0.1% with nanometer silver quality in the sponge structure after polycondensation reaction than percentage by volume.
Further, described semipermeable membrane is medical optionally thin film, described thin film allow solution by and silver ion pass through.
Further, described composite and semipermeable membrane compound as a whole, the size of described composite film-making and semipermeable membrane film-making adapts, and described semipermeable membrane its center has circular incision.
Further, described polyvinyl alcohol is medical PVA, and the scope of molecular weight is 120,000-18 ten thousand, and alcoholysis degree is 98% ~ 100%; Described antibacterial is silver iron compound or coordination compound, and described cross-linking agent is formaldehyde or glutaraldehyde, and described foaming agent is the combination of one or more in potassium carbonate, potassium bicarbonate, calcium carbonate, sodium carbonate and sodium bicarbonate; Described acid is for being selected from hydrochloric acid, acetic acid, phosphoric acid and acetic acid the combination of one or more; Described nano-Ag particles mean diameter is less than 10 nanometers.
Described hemostasis, the novel self-expanding composite of anti-infective, its preparation method comprises the following steps:
1) polyvinyl alcohol getting certain mass adds hot water uniform stirring to dissolving, and after cooling, adds cross-linking agent and foaming agent, stirs 15-30 minute, then adds antibacterial and acid obtains mixed solution, and agitating solution makes foaming to maximum volume, stirs;
2) curing molding obtains condensation polymer, washs condensation polymer, and washing is extremely neutral, dried.
The preparation method of described hemostasis, the novel self-expanding composite of anti-infective, the stirring used in preparation process is mechanical agitation, and the rotating speed of stirring is 1500-3000 rev/min.
The preparation method of described hemostasis, the novel self-expanding composite of anti-infective, described step 1) in, polyvinyl alcohol adds in the hot water of more than 98 DEG C, mechanical agitation speed is adjusted to the rotating speed of 2000-3000 rev/min, stirs 20-30 minute; Add the formalin that concentration is 37% after stirring, stir that to add concentration after 3-5 minute be 50% acetum;
Described step 2) in, the condensation polymer that curing molding obtains, puts into mould curing molding, and after curing molding, washing is to neutral, freeze-day with constant temperature.
The preparation method of described hemostasis, the novel self-expanding composite of anti-infective, step 1) in after mixed solution is heated to 70-80 DEG C, mechanical agitation speed is adjusted to the rotating speed of 1500-3000 rev/min, stirs after 15 minutes; Addition is that every 100 ml solns add 0.5ml glutaraldehyde solution, then to add concentration be 50% acetum 5ml; Start after stirring to reduce mixing speed, mixing speed is down to 500r/min, stops stirring after 100s;
Step 2) in, put into 50 DEG C of mould curing moldings about 10 hours; Add alkaline wash liquid finally in neutral.
The preparation method of described hemostasis, the novel self-expanding composite of anti-infective, specifically comprises the steps:
1) polyvinyl alcohol getting 25g mixes with 100g deionized water, with 3000 revs/min of mechanical agitation, polyvinyl alcohol is progressively dissolved, prepare mixed solution, be cooled to room temperature, simultaneously every 100g solution adds 0.3g foaming agent, stirs and after being slowly heated to 60 DEG C, mechanical agitation speed is adjusted to the rotating speed of 2500 revs/min, after stirring; In mixed solution, add the formalin of 37%, addition is that every 100 ml solns add 0.5ml formalin, and adding concentration again after continuing to stir certain hour is 50% acetum, and sour addition is that every 100 ml solns add 5ml acid solution; And every 100g solution adds the antibacterial of 5g; Start after stirring to reduce mixing speed, be down to 500r/min, stir, stop after 100s stirring;
2) pour mould into, put into 50 DEG C of mould curing molding 10h;
3) demoulding washing, the sponge after curing molding extrudes at normal temperatures, till having squeezed air, not have bubble to be as the criterion, then adds alkaline detergent solution washing to neutral;
4) extrusion dehydration, extrudes again, till having squeezed air, not have bubble to be as the criterion, then adds alkaline detergent solution washing to neutral;
5) processing and packing, cold preservation.
Beneficial effect of the present invention is:
The composite that the present invention makes can reduce permeability by increase semipermeable membrane and avoid wound surface to dewater, and wound surface of not easily adhering, make wound surface again mechanical injuries can not occur, the application of semipermeable membrane simultaneously makes external microbe not easily pass through, make silver ion can carry out sterilizing through semipermeable membrane to wound surface, make composite use so more effective, decrease replacing now, reduce consumption.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly understand, below in conjunction with detailed description of the invention, the present invention is described in more detail.Should be appreciated that, these describe just exemplary, and do not really want to limit the scope of the invention.In addition, in the following description, the description to known features and technology is eliminated, to avoid unnecessarily obscuring concept of the present invention.
Embodiment 1
A kind of hemostasis, the novel self-expanding composite of anti-infective, described composite comprises polyvinyl alcohol, antibacterial, cross-linking agent, acid and foaming agent, and the quality of described component than percentage by volume is:
By polyvinyl alcohol, antibacterial, cross-linking agent, acid and foaming agent in aqueous polycondensation reaction form, condensation polymer drying is cut in flakes, obtains wound surface composite with semipermeable membrane compound.
Embodiment 2
A kind of hemostasis, the novel self-expanding composite of anti-infective, described composite comprises polyvinyl alcohol, antibacterial, cross-linking agent, acid and foaming agent, and the quality of described component than percentage by volume is:
By polyvinyl alcohol, antibacterial, cross-linking agent, acid and foaming agent in aqueous polycondensation reaction form, condensation polymer drying is cut in flakes, obtains wound surface composite with semipermeable membrane compound.
Embodiment 3
A kind of hemostasis, the novel self-expanding composite of anti-infective, described composite comprises polyvinyl alcohol, antibacterial, cross-linking agent, acid and foaming agent, and the quality of described component than percentage by volume is:
By polyvinyl alcohol, antibacterial, cross-linking agent, acid and foaming agent in aqueous polycondensation reaction form, condensation polymer drying is cut in flakes, obtains wound surface composite with semipermeable membrane compound.
Described hemostasis, the novel self-expanding composite of anti-infective, its preparation method comprises the following steps:
1) polyvinyl alcohol getting certain mass adds hot water uniform stirring to dissolving, and after cooling, adds cross-linking agent and foaming agent, stirs 15 minutes, then adds antibacterial and acid obtains mixed solution, and agitating solution makes to foam to maximum volume, stirs;
2) curing molding obtains condensation polymer, washs condensation polymer, and washing is extremely neutral, dried.
The preparation method of described hemostasis, the novel self-expanding composite of anti-infective, the stirring used in preparation process is mechanical agitation, and the rotating speed of stirring is 3000 revs/min.
Or described hemostasis, the novel self-expanding composite of anti-infective, its preparation method comprises the following steps:
1) polyvinyl alcohol getting certain mass adds hot water uniform stirring to dissolving, and after cooling, adds cross-linking agent and foaming agent, stirs 30 minutes, then adds antibacterial and acid obtains mixed solution, and agitating solution makes to foam to maximum volume, stirs;
2) curing molding obtains condensation polymer, washs condensation polymer, and washing is extremely neutral, dried.
The preparation method of described hemostasis, the novel self-expanding composite of anti-infective, the stirring used in preparation process is mechanical agitation, and the rotating speed of stirring is 1500 revs/min.
The preparation method of described hemostasis, the novel self-expanding composite of anti-infective, described step 1) in, polyvinyl alcohol adds in the hot water of more than 98 DEG C, mechanical agitation speed is adjusted to the rotating speed of 3000 revs/min, stirs 20 minutes; Add the formalin that concentration is 37% after stirring, stir that to add concentration after 3 minutes be 50% acetum;
Described step 2) in, the condensation polymer that curing molding obtains, puts into mould curing molding, and after curing molding, washing is to neutral, freeze-day with constant temperature.
Or the preparation method of described hemostasis, the novel self-expanding composite of anti-infective, described step 1) in, polyvinyl alcohol adds in the hot water of more than 98 DEG C, mechanical agitation speed is adjusted to the rotating speed of 2000 revs/min, stirs 30 minutes; Add the formalin that concentration is 37% after stirring, stir that to add concentration after 5 minutes be 50% acetum;
Described step 2) in, the condensation polymer that curing molding obtains, puts into mould curing molding, and after curing molding, washing is to neutral, freeze-day with constant temperature.
The preparation method of described hemostasis, the novel self-expanding composite of anti-infective, step 1) in after mixed solution is heated to 70 DEG C, mechanical agitation speed is adjusted to the rotating speed of 3000 revs/min, stirs after 15 minutes; Addition is that every 100 ml solns add 0.5ml glutaraldehyde solution, then to add concentration be 50% acetum 5ml; Start after stirring to reduce mixing speed, mixing speed is down to 500r/min, stops stirring after 100s;
Step 2) in, put into 50 DEG C of mould curing moldings about 10 hours; Add alkaline wash liquid finally in neutral.
Or the preparation method of described hemostasis, the novel self-expanding composite of anti-infective, step 1) in after mixed solution is heated to 80 DEG C, mechanical agitation speed is adjusted to the rotating speed of 1500 revs/min, stirs after 15 minutes; Addition is that every 100 ml solns add 0.5ml glutaraldehyde solution, then to add concentration be 50% acetum 5ml; Start after stirring to reduce mixing speed, mixing speed is down to 500r/min, stops stirring after 100s;
Step 2) in, put into 50 DEG C of mould curing moldings about 10 hours; Add alkaline wash liquid finally in neutral.
Method 1
The preparation method of described hemostasis, the novel self-expanding composite of anti-infective, specifically comprises the steps:
1) polyvinyl alcohol getting 25g mixes with 100g deionized water, with 3000 revs/min of mechanical agitation, polyvinyl alcohol is progressively dissolved, prepare mixed solution, be cooled to room temperature, simultaneously every 100g solution adds 0.3g foaming agent, stirs and after being slowly heated to 60 DEG C, mechanical agitation speed is adjusted to the rotating speed of 2500 revs/min, after stirring; In mixed solution, add the formalin of 37%, addition is that every 100 ml solns add 0.5ml formalin, and adding concentration again after continuing to stir certain hour is 50% acetum, and sour addition is that every 100 ml solns add 5ml acid solution; And every 100g solution adds the antibacterial of 5g; Start after stirring to reduce mixing speed, be down to 500r/min, stir, stop after 100s stirring;
2) pour mould into, put into 50 DEG C of mould curing molding 10h;
3) demoulding washing, the sponge after curing molding extrudes at normal temperatures, till having squeezed air, not have bubble to be as the criterion, then adds alkaline detergent solution washing to neutral;
4) extrusion dehydration, extrudes again, till having squeezed air, not have bubble to be as the criterion, then adds alkaline detergent solution washing to neutral;
5) processing and packing, cold preservation.
Method 2
The preparation method of described hemostasis, the novel self-expanding composite of anti-infective, specifically comprises the steps:
1) polyvinyl alcohol getting 20g mixes with 100g deionized water, with 3000 revs/min of mechanical agitation, polyvinyl alcohol is progressively dissolved, prepare mixed solution, be cooled to room temperature, simultaneously every 100g solution adds 0.2g foaming agent, stirs and after being slowly heated to 60 DEG C, mechanical agitation speed is adjusted to the rotating speed of 2500 revs/min, after stirring; In mixed solution, add the formalin of 37%, addition is that every 100 ml solns add 0.5ml formalin, and adding concentration again after continuing to stir certain hour is 50% acetum, and sour addition is that every 100 ml solns add 5ml acid solution; And every 100g solution adds the antibacterial of 4g; Start after stirring to reduce mixing speed, be down to 500r/min, stir, stop after 100s stirring;
2) pour mould into, put into 50 DEG C of mould curing molding 10h;
3) demoulding washing, the sponge after curing molding extrudes at normal temperatures, till having squeezed air, not have bubble to be as the criterion, then adds alkaline detergent solution washing to neutral;
4) extrusion dehydration, extrudes again, till having squeezed air, not have bubble to be as the criterion, then adds alkaline detergent solution washing to neutral;
5) processing and packing, cold preservation.
Method 3
The preparation method of described hemostasis, the novel self-expanding composite of anti-infective, specifically comprises the steps:
1) polyvinyl alcohol getting 30g mixes with 100g deionized water, with 3000 revs/min of mechanical agitation, polyvinyl alcohol is progressively dissolved, prepare mixed solution, be cooled to room temperature, simultaneously every 100g solution adds 0.4g foaming agent, stirs and after being slowly heated to 60 DEG C, mechanical agitation speed is adjusted to the rotating speed of 2500 revs/min, after stirring; In mixed solution, add the formalin of 37%, addition is that every 100 ml solns add 1ml formalin, and adding concentration again after continuing to stir certain hour is 50% acetum, and sour addition is that every 100 ml solns add 5ml acid solution; And every 100g solution adds the antibacterial of 6g; Start after stirring to reduce mixing speed, be down to 500r/min, stir, stop after 100s stirring;
2) pour mould into, put into 50 DEG C of mould curing molding 10h;
3) demoulding washing, the sponge after curing molding extrudes at normal temperatures, till having squeezed air, not have bubble to be as the criterion, then adds alkaline detergent solution washing to neutral;
4) extrusion dehydration, extrudes again, till having squeezed air, not have bubble to be as the criterion, then adds alkaline detergent solution washing to neutral;
5) processing and packing, cold preservation.
The hemostasis prepared as stated above, the novel self-expanding composite of anti-infective, possesses uniform hole, the size range in aperture is 1-10 micron, can effectively absorb water, after water suction, quality is soft, possesses good pliability, to this hemostasis, the novel self-expanding composite of anti-infective carries out antibiotic property test, adopt " antibacterial fabric method for testing performance FZ/T01021-1992 ", with staphylococcus aureus, escherichia coli and bacillus pyocyaneus carry out the antibacterial effect evaluation of material, antibiotic rate can reach more than 99.9%, simultaneously can available protecting wound surface, reduce utilization rate, for original dressing, the time that the present invention uses is original twice, alleviate the misery of patient.
As following table 1:
The antibiotic property test that table 1 is hemostasis, the novel self-expanding composite of anti-infective
Should be understood that, above-mentioned detailed description of the invention of the present invention only for exemplary illustration or explain principle of the present invention, and is not construed as limiting the invention.Therefore, any amendment made when without departing from the spirit and scope of the present invention, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.In addition, claims of the present invention be intended to contain fall into claims scope and border or this scope and border equivalents in whole change and modification.
Claims (10)
1. hemostasis, the novel self-expanding composite of anti-infective, it is characterized in that, described composite comprises polyvinyl alcohol, antibacterial, cross-linking agent, acid and foaming agent, and the quality of described component than percentage by volume is:
By polyvinyl alcohol, antibacterial, cross-linking agent, acid and foaming agent in aqueous polycondensation reaction form, condensation polymer drying is cut in flakes, obtains wound surface composite with semipermeable membrane compound.
2. one hemostasis according to claim 1, the novel self-expanding composite of anti-infective, it is characterized in that: the nanometer silver in described composite is adsorbed in sponge structure, is 0.01-0.1% with nanometer silver quality in the sponge structure after polycondensation reaction than percentage by volume.
3. one hemostasis according to claim 1, the novel self-expanding composite of anti-infective, is characterized in that: described semipermeable membrane is medical optionally thin film, described thin film allow solution by and silver ion pass through.
4. one hemostasis according to claim 1, the novel self-expanding composite of anti-infective, it is characterized in that: described composite and semipermeable membrane compound as a whole, the size of described composite film-making and semipermeable membrane film-making adapts, and described semipermeable membrane its center has circular incision.
5. one hemostasis according to claim 1 and 2, the novel self-expanding composite of anti-infective, it is characterized in that: described polyvinyl alcohol is medical PVA, the scope of molecular weight is 120,000-18 ten thousand, and alcoholysis degree is 98% ~ 100%; Described antibacterial is silver iron compound or coordination compound, and described cross-linking agent is formaldehyde or glutaraldehyde, and described foaming agent is the combination of one or more in potassium carbonate, potassium bicarbonate, calcium carbonate, sodium carbonate and sodium bicarbonate; Described acid is for being selected from hydrochloric acid, acetic acid, phosphoric acid and acetic acid the combination of one or more; Described nano-Ag particles mean diameter is less than 10 nanometers.
6. one hemostasis according to claim 1, the novel self-expanding composite of anti-infective, is characterized in that: its preparation method comprises the following steps:
1) polyvinyl alcohol getting certain mass adds hot water uniform stirring to dissolving, and after cooling, adds cross-linking agent and foaming agent, stirs 15-30 minute, then adds antibacterial and acid obtains mixed solution, and agitating solution makes foaming to maximum volume, stirs;
2) curing molding obtains condensation polymer, washs condensation polymer, and washing is extremely neutral, dried.
7. the preparation method of a kind of hemostasis according to claim 6, the novel self-expanding composite of anti-infective, is characterized in that: the stirring used in preparation process is mechanical agitation, the rotating speed of stirring is 1500-3000 rev/min.
8. the preparation method of a kind of hemostasis according to claim 6, the novel self-expanding composite of anti-infective, it is characterized in that: described step 1) in, polyvinyl alcohol adds in the hot water of more than 98 DEG C, mechanical agitation speed is adjusted to the rotating speed of 2000-3000 rev/min, stirs 20-30 minute; Add the formalin that concentration is 37% after stirring, stir that to add concentration after 3-5 minute be 50% acetum;
Described step 2) in, the condensation polymer that curing molding obtains, puts into mould curing molding, and after curing molding, washing is to neutral, freeze-day with constant temperature.
9. the preparation method of a kind of hemostasis according to claim 6, the novel self-expanding composite of anti-infective, is characterized in that:
Step 1) in after mixed solution is heated to 70-80 DEG C, mechanical agitation speed is adjusted to the rotating speed of 1500-3000 rev/min, stirs after 15 minutes; Addition is that every 100 ml solns add 0.5ml glutaraldehyde solution, then to add concentration be 50% acetum 5ml; Start after stirring to reduce mixing speed, mixing speed is down to 500r/min, stops stirring after 100s;
Step 2) in, put into 50 DEG C of mould curing moldings about 10 hours; Add alkaline wash liquid finally in neutral.
10. the preparation method of a kind of hemostasis according to claim 6, the novel self-expanding composite of anti-infective, is characterized in that: specifically comprise the steps:
1) polyvinyl alcohol getting 25g mixes with 100g deionized water, with 3000 revs/min of mechanical agitation, polyvinyl alcohol is progressively dissolved, prepare mixed solution, be cooled to room temperature, simultaneously every 100g solution adds 0.3g foaming agent, stirs and after being slowly heated to 60 DEG C, mechanical agitation speed is adjusted to the rotating speed of 2500 revs/min, after stirring; The formalin of 37% is added in mixed solution, addition is that every 100 ml solns add 0.5ml formalin, adding concentration again after continuing to stir certain hour is 50% acetum, acid addition is that every 100 ml solns add 5ml acid solution, and every 100g solution adds the antibacterial of 5g; Start after stirring to reduce mixing speed, be down to 500r/min, stir, stop after 100s stirring;
2) pour mould into, put into 50 DEG C of mould curing molding 10h;
3) demoulding washing, the sponge after curing molding extrudes at normal temperatures, till having squeezed air, not have bubble to be as the criterion, then adds alkaline detergent solution washing to neutral;
4) extrusion dehydration, extrudes again, till having squeezed air, not have bubble to be as the criterion, then adds alkaline detergent solution washing to neutral;
5) processing and packing, cold preservation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510762697.0A CN105251034B (en) | 2015-11-11 | 2015-11-11 | It is a kind of hemostasis, anti-infectious surface of a wound composite material |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510762697.0A CN105251034B (en) | 2015-11-11 | 2015-11-11 | It is a kind of hemostasis, anti-infectious surface of a wound composite material |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105251034A true CN105251034A (en) | 2016-01-20 |
CN105251034B CN105251034B (en) | 2019-03-01 |
Family
ID=55091151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510762697.0A Expired - Fee Related CN105251034B (en) | 2015-11-11 | 2015-11-11 | It is a kind of hemostasis, anti-infectious surface of a wound composite material |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105251034B (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105778371A (en) * | 2016-03-21 | 2016-07-20 | 苏州越湖海绵复合厂 | Air-permeable sponge material and preparation method thereof |
CN105778370A (en) * | 2016-03-21 | 2016-07-20 | 苏州越湖海绵复合厂 | High-resilience sponge material and preparation method thereof |
CN105816909A (en) * | 2016-05-10 | 2016-08-03 | 北京科技大学 | Method for preparing high-elasticity high-absorbency hemostatic and bacteriostatic expansive sponge |
CN113693821A (en) * | 2021-08-26 | 2021-11-26 | 北京中杰瑞康科技有限公司 | Self-expansion super-water-absorption water-locking micro-negative pressure dressing and preparation method thereof |
CN114632184A (en) * | 2022-03-22 | 2022-06-17 | 广州华一生物科技有限公司 | Preparation method and application of automatic absorbing and swelling dressing |
CN114796586A (en) * | 2022-05-23 | 2022-07-29 | 广州华一生物科技有限公司 | Anti-adhesion micro-negative pressure self-suction wound protection system |
CN115572558A (en) * | 2022-09-07 | 2023-01-06 | 安徽大地熊新材料股份有限公司 | Environment-friendly magnet fixing material and preparation method and application thereof |
CN116769411A (en) * | 2023-08-24 | 2023-09-19 | 广州博达医疗用品有限公司 | Disposable antibacterial surgical membrane and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1095387A (en) * | 1994-05-09 | 1994-11-23 | 朱铁桥 | Polyvinyl alcohol foam material for medical sanitation |
JP2000167036A (en) * | 1998-12-03 | 2000-06-20 | Kwangju Inst Of Science & Technol | Injury curing medical material |
CN1721003A (en) * | 2004-07-12 | 2006-01-18 | 深圳市清华源兴生物医药科技有限公司 | Medical antibiotic dressing |
CN101954115A (en) * | 2010-10-22 | 2011-01-26 | 佘振定 | Medical antibacterial sponge dressing and preparation method thereof |
CN102286184A (en) * | 2011-06-23 | 2011-12-21 | 威海世创医疗科技有限公司 | Carboxymethyl chitosan/ polyvinyl alcohol porous composite material and preparation method thereof |
-
2015
- 2015-11-11 CN CN201510762697.0A patent/CN105251034B/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1095387A (en) * | 1994-05-09 | 1994-11-23 | 朱铁桥 | Polyvinyl alcohol foam material for medical sanitation |
JP2000167036A (en) * | 1998-12-03 | 2000-06-20 | Kwangju Inst Of Science & Technol | Injury curing medical material |
CN1721003A (en) * | 2004-07-12 | 2006-01-18 | 深圳市清华源兴生物医药科技有限公司 | Medical antibiotic dressing |
CN101954115A (en) * | 2010-10-22 | 2011-01-26 | 佘振定 | Medical antibacterial sponge dressing and preparation method thereof |
CN102286184A (en) * | 2011-06-23 | 2011-12-21 | 威海世创医疗科技有限公司 | Carboxymethyl chitosan/ polyvinyl alcohol porous composite material and preparation method thereof |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105778371A (en) * | 2016-03-21 | 2016-07-20 | 苏州越湖海绵复合厂 | Air-permeable sponge material and preparation method thereof |
CN105778370A (en) * | 2016-03-21 | 2016-07-20 | 苏州越湖海绵复合厂 | High-resilience sponge material and preparation method thereof |
CN105816909A (en) * | 2016-05-10 | 2016-08-03 | 北京科技大学 | Method for preparing high-elasticity high-absorbency hemostatic and bacteriostatic expansive sponge |
CN113693821A (en) * | 2021-08-26 | 2021-11-26 | 北京中杰瑞康科技有限公司 | Self-expansion super-water-absorption water-locking micro-negative pressure dressing and preparation method thereof |
CN113693821B (en) * | 2021-08-26 | 2022-10-21 | 北京中杰瑞康科技有限公司 | Self-expansion super-water-absorption water-locking micro-negative pressure dressing and preparation method thereof |
CN114632184A (en) * | 2022-03-22 | 2022-06-17 | 广州华一生物科技有限公司 | Preparation method and application of automatic absorbing and swelling dressing |
CN114796586A (en) * | 2022-05-23 | 2022-07-29 | 广州华一生物科技有限公司 | Anti-adhesion micro-negative pressure self-suction wound protection system |
CN115572558A (en) * | 2022-09-07 | 2023-01-06 | 安徽大地熊新材料股份有限公司 | Environment-friendly magnet fixing material and preparation method and application thereof |
CN116769411A (en) * | 2023-08-24 | 2023-09-19 | 广州博达医疗用品有限公司 | Disposable antibacterial surgical membrane and preparation method thereof |
CN116769411B (en) * | 2023-08-24 | 2023-10-17 | 广州博达医疗用品有限公司 | Disposable antibacterial surgical membrane and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN105251034B (en) | 2019-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105251034A (en) | Novel self-expanding composite material with hemostatic and anti-infectious effects and preparation method | |
CN102258801B (en) | Sponge calcium alginate medical dressing, and preparation method | |
Cao et al. | Double crosslinking chitosan sponge with antibacterial and hemostatic properties for accelerating wound repair | |
CN104069537B (en) | Sodium alginate-sodium carboxymethyl cellulose-Chitosan in Wound Dressing and preparation method thereof | |
CN101954115B (en) | Medical antibacterial sponge dressing and preparation method thereof | |
EP3044353B1 (en) | Method of producing a swellable polymer fibre | |
CN103736134B (en) | Medical sponge dressing and preparation method thereof | |
US20050287193A1 (en) | Wound dressing made of chitin and alginate and method for forming the same | |
CN101613512B (en) | Rapid-imbibing foamed material with antibacterial property and preparation method thereof | |
CN109942905B (en) | Composite hydrogel material and preparation method thereof | |
WO2014044011A1 (en) | Alginate woven fabrics and method for preparing the same | |
CN105641733A (en) | Preparation method for compound antibacterial haemostatic wound dressing | |
HU186129B (en) | Bsorptive wound ligament and process for the production thereof | |
Cao et al. | Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair | |
CN103656734A (en) | Wound-healing dressing film | |
CN109224116A (en) | A kind of the antibacterial anti hemorrhagic medical dressing and preparation method of high-absorbable | |
CN105381500A (en) | Functional wound surface repairing material and preparation method thereof | |
CN104623719A (en) | Chitosan hydrogel dressing and preparation method of chitosan hydrogel dressing | |
CN109498834B (en) | Antibacterial hydrocolloid dressing and preparation method thereof | |
CN108815562A (en) | A kind of preparation method of compound hemostatic material | |
CN112206342A (en) | Alginate composite dressing and preparation method thereof | |
CN113730645B (en) | Sponge for rapid hemostasis and wound repair and preparation method thereof | |
TWI499436B (en) | Fiber-forming hydrogel composition and preparation method | |
CN113980326A (en) | High-antibacterial-property chitosan-silver composite sponge and preparation method and application thereof | |
CN112760824A (en) | Preparation method of full-biodegradable antibacterial dressing |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190301 Termination date: 20211111 |
|
CF01 | Termination of patent right due to non-payment of annual fee |