A kind of department of anesthesia often uses sterilizing sponge
Technical field
The present invention relates to medical sponge technical field more particularly to a kind of departments of anesthesia often to use sterilizing sponge.
Background technology
Artificial sponge is also known as synthetic sponge.Artificial sponge is polymerisation mutually to occur using macromolecule, while being added not
Same additive and foaming agent, a kind of sponge made of finally drying is made.The wherein difference of raw material and proportioning leads to making for sponge
With range difference.Artificial sponge not only has the porous structure of natural sponge, the features such as also having both heat preservation and high resiliency.It is existing
Artificial sponge is generally referred to as flexible polyurethane blown rubber, is a kind of chemical products, and primary colors is rice white, but for a long time in air
Middle oxidation becomes yellow, and the color of certain sponge is that manual selectivity controls as a result, constantly changing with the demand of people.
In production, with the continuous improvement that people require variety classes and purposes sponge, also prepared using different molds various
The sponge of shape.
Artificial sponge can be divided into number of different types according to the raw material of preparation, elasticity, purposes and density.Wherein prepare artificial sea
Continuous raw material is broadly divided into polyurethane and polyvinyl alcohol;It can be divided into slow elastic sponge, common sea according to the elastic size of sponge
Tender high elasticity sponge;According to the different purposes of sponge, stiffened sponge, flame-retardant sponge, antistatic sponge etc. can be divided into;Structure is tight
Close different artificial sponge can be divided into low-density sponge and high-density sponge.The purposes of sponge in people's daily life is very
Extensively, this difference for also determining sponge shape, color and performance can made to meet the various demands of its practical application
Suitable raw material and additive are selected during standby, prepares different performance artificial sponge, to meet people to sponge items
The requirement of performance.
Existing department of anesthesia is often primarily present following problem with sponge:(1) water absorption rate is low, and then causes anthemorrhagic speed slow;
(2) disinfection effect is poor, does not promote good curative effect to human body in actual use, there are one on
Fixed limitation.
Therefore, the present invention proposes a kind of department of anesthesia often with sterilizing sponge for solving the above problems.
Invention content
The purpose of the present invention is to solve departments of anesthesia in the prior art often with sponge there are anthemorrhagic speeds slow, sterilizing
The technical problem of effect difference, and a kind of department of anesthesia proposed often uses sterilizing sponge.
A kind of department of anesthesia often uses sterilizing sponge, preparation process to include the following steps:
(1) poly-vinyl alcohol solution that configuration concentration is 20~25%;
(2) Chitosan powder and foaming agent are added into poly-vinyl alcohol solution, stirs 40~60min, obtains mixed liquor;Institute
The addition for stating Chitosan powder is 30~40wt% of poly-vinyl alcohol solution;The addition of the foaming agent is that polyvinyl alcohol is molten
5~10wt% of liquid;
(3) pH adjusting agent is added in the mixed liquor obtained to step (2) makes the pH value of mixed liquor be maintained at 6~8, stirs,
Temperature is kept to stablize at 40~45 DEG C;
(4) crosslinking agent is added, stirs 40~60min, sterilization modifying agent is added, continues 40~60min of stirring, takes out production
Object;The crosslinking agent is made of hexa and glyoxal, wherein the weight ratio of hexa and glyoxal is 1:
4~6;The addition of the crosslinking agent is 10~15wt% of poly-vinyl alcohol solution;The addition of the modified fungicide is poly-
10~15wt% of glycohol solution;
(5) product that step (4) is taken out is poured into diaphragm capsule, baking molding;
(6) it takes out the molding product distilled water of step (5) or deionized water is cleaned to dry and be killed to get to department of anesthesia is common
Bacterium disinfection sponge.
Preferably, sterilization modifying agent is made of povidone iodine and compound (I) in step (4), wherein povidone iodine, change
The weight ratio for closing object (I) is 1:3, the structural formula of compound (I) is as follows:
Preferably, baking temperature is 50-70 DEG C in step (5).
Preferably, mixing time is 20~30min in step (3).
Preferably, pH adjusting agent is hydrochloric acid, sulfuric acid, sodium hydroxide, one kind in potassium hydroxide in step (3).
Preferably, foaming agent is Tween-80, Tween-60, Tween-40, one kind in Tween-20 or several in step (2)
Kind.
Department of anesthesia proposed by the present invention is often had the following technical effect that with sterilizing sponge:
(1) crosslinking agent is made of hexa and glyoxal, and by lot of experiment validation, is finally determined best
Crosslinking agent dosage and crosslinking agent in ratio between hexa and glyoxal, so that the water imbibition of sponge is reached most
Best performance.If the ratio control in the dosage or crosslinking agent of crosslinking agent between each component is improper, crosslinking will be caused too weak or handed over
Connection is excessive, and then reduces the water absorption rate of sponge, influences anthemorrhagic speed.
(2) modification liquid is sterilized by addition, and heavy between povidone iodine and compound (I) in rationally control sterilization modification liquid
Ratio is measured, significantly improves the disinfection effect of sponge, and then improve curative effect.
(3) preparation method proposed by the present invention, equipment requirement is low, operation rationally, it is simple, the sponge of preparation can directly into
Treatment of practising medicine uses, easy to spread.
Description of the drawings
Fig. 1 is microstructure of the sponge of the invention being prepared under electron microscope (SEM).
Specific implementation mode
The present invention is made further to explain with reference to specific embodiment.
Embodiment 1
A kind of department of anesthesia often uses sterilizing sponge, preparation process to include the following steps:
(1) poly-vinyl alcohol solution that configuration concentration is 20%;
(2) Chitosan powder and foaming agent are added into poly-vinyl alcohol solution, stirs 40min, obtains mixed liquor;The shell
The addition of glycan powder is the 30wt% of poly-vinyl alcohol solution;The addition of the foaming agent is poly-vinyl alcohol solution
5wt%;
(3) pH adjusting agent is added in the mixed liquor obtained to step (2) makes the pH value of mixed liquor be maintained at 6, stirs, and keeps
Temperature is stablized at 40 DEG C;
(4) crosslinking agent is added, stirs 40min, sterilization modifying agent is added, continues to stir 40min, takes out product;The friendship
Connection agent is made of hexa and glyoxal, wherein the weight ratio of hexa and glyoxal is 1:4;The friendship
The addition for joining agent is the 10wt% of poly-vinyl alcohol solution;The addition of the modified fungicide is poly-vinyl alcohol solution
10wt%;
(5) product that step (4) is taken out is poured into diaphragm capsule, baking molding;
(6) it takes out the molding product distilled water of step (5) or deionized water is cleaned to dry and be killed to get to department of anesthesia is common
Bacterium disinfection sponge.
Wherein, sterilization modifying agent is made of povidone iodine and compound (I) in step (4), wherein povidone iodine, chemical combination
The weight ratio of object (I) is 1:3, the structural formula of compound (I) is as follows:
Wherein, baking temperature is 50 DEG C in step (5), and mixing time is 20min in step (3), and pH is adjusted in step (3)
Agent is hydrochloric acid, sulfuric acid, sodium hydroxide, one kind in potassium hydroxide, and foaming agent is Tween-80 in step (2).
Embodiment 2
A kind of department of anesthesia often uses sterilizing sponge, preparation process to include the following steps:
(1) poly-vinyl alcohol solution that configuration concentration is 23%;
(2) Chitosan powder and foaming agent are added into poly-vinyl alcohol solution, stirs 50min, obtains mixed liquor;The shell
The addition of glycan powder is the 35wt% of poly-vinyl alcohol solution;The addition of the foaming agent is poly-vinyl alcohol solution
8wt%;
(3) pH adjusting agent is added in the mixed liquor obtained to step (2) makes the pH value of mixed liquor be maintained at 7, stirs, and keeps
Temperature is stablized at 43 DEG C;
(4) crosslinking agent is added, stirs 50min, sterilization modifying agent is added, continues to stir 50min, takes out product;The friendship
Connection agent is made of hexa and glyoxal, wherein the weight ratio of hexa and glyoxal is 1:5;The friendship
The addition for joining agent is the 103wt% of poly-vinyl alcohol solution;The addition of the modified fungicide is poly-vinyl alcohol solution
13wt%;
(5) product that step (4) is taken out is poured into diaphragm capsule, baking molding;
(6) it takes out the molding product distilled water of step (5) or deionized water is cleaned to dry and be killed to get to department of anesthesia is common
Bacterium disinfection sponge.
Wherein, sterilization modifying agent is made of povidone iodine and compound (I) in step (4), wherein povidone iodine, chemical combination
The weight ratio of object (I) is 1:3, the structural formula of compound (I) is as follows:
Wherein, baking temperature is 60 DEG C in step (5), and mixing time is 25min in step (3), and pH is adjusted in step (3)
Agent is hydrochloric acid, sulfuric acid, sodium hydroxide, one kind in potassium hydroxide, and foaming agent is Tween-60 in step (2).
Embodiment 3
A kind of department of anesthesia often uses sterilizing sponge, preparation process to include the following steps:
(1) poly-vinyl alcohol solution that configuration concentration is 25%;
(2) Chitosan powder and foaming agent are added into poly-vinyl alcohol solution, stirs 60min, obtains mixed liquor;The shell
The addition of glycan powder is the 40wt% of poly-vinyl alcohol solution;The addition of the foaming agent is poly-vinyl alcohol solution
10wt%;
(3) pH adjusting agent is added in the mixed liquor obtained to step (2) makes the pH value of mixed liquor be maintained at 8, stirs, and keeps
Temperature is stablized at 45 DEG C;
(4) crosslinking agent is added, stirs 60min, sterilization modifying agent is added, continues to stir 60min, takes out product;The friendship
Connection agent is made of hexa and glyoxal, wherein the weight ratio of hexa and glyoxal is 1:6;The friendship
The addition for joining agent is the 15wt% of poly-vinyl alcohol solution;The addition of the modified fungicide is poly-vinyl alcohol solution
15wt%;
(5) product that step (4) is taken out is poured into diaphragm capsule, baking molding;
(6) it takes out the molding product distilled water of step (5) or deionized water is cleaned to dry and be killed to get to department of anesthesia is common
Bacterium disinfection sponge.
Wherein, sterilization modifying agent is made of povidone iodine and compound (I) in step (4), wherein povidone iodine, chemical combination
The weight ratio of object (I) is 1:3, the structural formula of compound (I) is as follows:
Wherein, baking temperature is 70 DEG C in step (5), and mixing time is 30min in step (3), and pH is adjusted in step (3)
Agent is hydrochloric acid, sulfuric acid, sodium hydroxide, one kind in potassium hydroxide, and foaming agent is Tween-40 in step (2).
Comparative example 1~8
Comparative example 1~8 only changes the weight ratio of the pH of mixed liquor, hexa and glyoxal in embodiment 2, and
The weight ratio of povidone iodine and compound (I), other parameters are same as Example 2.
The Parameters variation situation of Examples 1 to 3 and comparative example 1~8 is listed in Table 1 below.
Table 1
Number |
PH of mixed |
Hexa:Glyoxal |
Povidone iodine:Compound (I) |
Embodiment 1 |
6 |
1:4 |
1:3 |
Embodiment 2 |
7 |
1:5 |
1:3 |
Embodiment 3 |
8 |
1:6 |
1:3 |
Comparative example 1 |
5 |
1:5 |
1:3 |
Comparative example 2 |
9 |
1:5 |
1:3 |
Comparative example 3 |
7 |
Only addition hexa |
1:3 |
Comparative example 4 |
7 |
Only addition glyoxal |
1:3 |
Comparative example 5 |
7 |
1:3 |
1:3 |
Comparative example 6 |
7 |
1:7 |
1:3 |
Comparative example 7 |
7 |
1:5 |
1:2 |
Comparative example 8 |
7 |
1:5 |
1:4 |
The present invention characterizes the technique effect of the present invention by water absorbing properties and bactericidal property, and specific assay method is as follows:
Water absorbing properties measure:It takes the styptic sponge with certain specification size in claiming quality on assay balance, is denoted as m0.It will
It is put into distilled water, is pulled out after it fully absorbs water, claims quality after natural draining, be denoted as mt(for very soluble hemostasis
Sponge pours out distilled water then after it fully absorbs water, and claims styptic sponge quality).Then its water absorption rate is ((mt–m0)/m0)×
100%.
Bactericidal property measures:Test uses staphylococcus aureus, and prepared sponge is shredded and is placed after inoculation
Culture dish center is placed in incubator one day under the same conditions.The variation of its pattern is observed, sponge is evaluated with inhibition zone diameter size
Anti-microbial property.
The water absorbing properties measurement result and bactericidal property measurement result of Examples 1 to 3 and comparative example 1~8 are listed in table 2
In.
Table 2
"-" expression does not detect the performance in upper table.
As can be seen from Table 2:(1) there is the present invention best crosslinking agent to form, and the water imbibition of sponge is made to reach best
Performance.If the ratio control in the dosage or crosslinking agent of crosslinking agent between each component is improper, crosslinking will be caused too weak or crosslinking
Excessively, so reduce sponge water absorption rate, influence anthemorrhagic speed;(2) modification liquid is sterilized by addition, and rationally control sterilization changes
Weight ratio between povidone iodine and compound (I), significantly improves the disinfection effect of sponge, and then improve and control in property liquid
More effect.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.