CN108524777A - A kind of preparation method of stem of noble dendrobium eye ointment - Google Patents
A kind of preparation method of stem of noble dendrobium eye ointment Download PDFInfo
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Abstract
The invention discloses a kind of stem of noble dendrobium eye ointment and preparation method thereof, and eye ointment is made of stone flower, Radix Ophiopogonis, cicada slough, snake slough, Equisetum hiemale Linne, cassia seed, the bark of ash, vaseline, eucalyptus oil, tea oil, bacteriostatic agent, conditioning agent, isotonic agent and thickener.Stem of noble dendrobium eye ointment prepared by the present invention, preparation process is simple, to improving and curing eye fatigue significant effect, while can also effectively improve eyesight, without side-effects to human body.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of preparation method of stem of noble dendrobium eye ointment.
Background technology
Often there is the phenomenon that eye fatigue since people watch TV, computer, using mobile phone for a long time in modern society,
It is mainly reflected in that the phenomenon that dry and astringent, sour swollen, eye-blurred or even visual impairment occur in eyes, while also resulting in the neck of people, shoulder
There is pain in equal corresponding sites, can also cause and aggravate various eye disease, seriously affect the work and life of people.
In actual life, people are often used the symptom that eyedrops carrys out relieving eye strain, but eyedrops is mostly Western medicine system
At containing micro preservative, for a long time using normal tear film can be caused to be destroyed, corneal epithelial tissue is damaged, right
Eyes are harmful.
Invention content
The purpose of the present invention is for existing problem, provide a kind of preparation method of stem of noble dendrobium eye ointment.
The present invention is achieved by the following technical solutions：
A kind of stem of noble dendrobium eye ointment, by weight component are as follows：5-15 parts of stone flower, Radix Ophiopogonis 10-20 part, 10-30 parts of cicada slough, snake slough
10-25 parts, 10-20 parts of Equisetum hiemale Linne, 5-15 parts of cassia seed, 5-10 parts of the bark of ash, 30-50 parts of vaseline, 1-3 parts of eucalyptus oil, tea tree
1-2 parts oily, 1-3 parts of bacteriostatic agent, 2-5 parts of conditioning agent, 1-5 parts of isotonic agent, 5-10 parts of thickener.
Preferably, a kind of stem of noble dendrobium eye ointment, the preparation method of wherein bacteriostatic agent are as follows：
1）5-15 parts of borneol, 5-10 parts of folium artemisiae argyi, 5-20 parts of cloves, 5-15 parts of blackberry lily are taken, 20-50 parts of 50-80% of addition after mixing
Ethyl alcohol carries out centrifugation oscillation, hunting power 200-500W, and duration of oscillation 20-30min waits being evaporated under reduced pressure back after vibrating
Ethyl alcohol is received, takes filtrate spare after solution is filtered；
2）By 1）In filtrate with pure water dilute 5-8 times can be prepared by.
Preferably, the preparation process one of a kind of stem of noble dendrobium eye ointment, wherein conditioning agent is as follows：
1）100-800 parts of pure water is taken, 1-5 parts of anhydrous sodium dihydrogen phosphate is added, vibrates and stirs evenly after mixing, it is spare；
2）100-500 parts of pure water is taken, 1-3 parts of Anhydrous Disodium Phosphate is added, vibrates and stirs evenly after mixing, it is spare；
3）Take 1）With 2）In solution according to 1-2:The solution that pH is 6-8 is made in the weight proportion of 2-3.
Preferably, a kind of stem of noble dendrobium eye ointment, isotonicity agent are the grapes of the sodium chloride solution and 20-40% by 0.6-1.2%
Sugar juice is according to 1-2:What the weight proportion of 2-3 was mixed with.
Preferably, a kind of stem of noble dendrobium eye ointment, wherein thickener are by methylcellulose, hydroxypropyl methyl cellulose and poly- sorb
Ester is according to 1-2:1-3:The weight proportion of 2-3 is mixed and made into viscosity and can be prepared by for 4.0-5.0cpa.s.
Preferably, a kind of preparation method of stem of noble dendrobium eye ointment, is as follows：
1）Take Radix Ophiopogonis 10-20 part, 10-30 parts of cicada slough, 10-25 parts of snake slough, 10-20 parts of Equisetum hiemale Linne, 5-15 parts of cassia seed, bark of ash 5-
10 parts, 50-100 parts of pure water is added after mixing, is decocted, obtained concoction is added to D101 large pore resin absorption columns
On, it is eluted with the ethyl alcohol of 20-30%, collects 20-30 parts of eluents, then eluted with the ethyl alcohol of 50-80%, collect 20-
40 parts of eluents will be recovered under reduced pressure ethyl alcohol after mixing by eluent twice, and take filtrate spare after filtering；
2）A container is taken, has one layer of latticed baffle, baffle to take 30-80 parts of stone flower apart from bottom 10-15cm inside container,
It is laid on baffle, lay thickness is 2-5cm, and bottom is equipped with 1）In filtrate, container inner pressure is down to 2-5Kpa, container is close
It is honored as a queen and is heated to 30-40 DEG C, fumigate 10-30min；
3）The stone flower after fumigating is taken out, the particle that 400-600 mesh is crushed to after drying is spare；
4）Take 30-50 parts of vaseline, 1-3 parts of eucalyptus oil, 1-2 parts of tea oil, after mixing be added 5-10 parts of pure water in into
Row heating, heating temperature are 70-90 DEG C, after vaseline is melted into viscous pasty state, sequentially add 3）In particle, bacteriostatic agent 1-
3 parts, 2-5 parts of conditioning agent, 1-5 parts of isotonic agent, 5-10 parts of thickener, carry out oscillation stirring, rotating speed 100-300r/min, stirring
After natural cooling air-dry can be prepared by a kind of stem of noble dendrobium eye ointment.
The present invention has the following advantages compared with prior art：
1. the borneol that the present invention is extracted using ethyl alcohol extractive technique from borneol, folium artemisiae argyi, cloves, blackberry lily, is penetrated Eugenol
Dry ketone has efficient sterilization and anticorrosion effect, can effectively extend the pot life of eye ointment, while being free from side effects to human body.
2. eye ointment main component prepared by the present invention is the stem of noble dendrobium, the dendrobine and dendrobium polysaccharide contained in the stem of noble dendrobium is to because of gala
Enzymatic activity anomalous variation caused by sugar missing has inhibition and role of correcting, can also prevent the crystalline substance caused by galactolipin lacks
The total esters of shape body and total cholesterol it is out of proportion, while dyshaemia can also be improved, improved caused by cell ischemic, anoxic
The effect of metabolic dysfunction, can enhance local organization metabolic capability, and promotion does not lose function, under holddown completely
Nerve fibre by repair make its play compensation, contribute to aggrieved visual cell and optic nerve fiber functional recovery, play
Eyesight is improved, the effect of eye fatigue is cured, all there is fine curative effect for cataract, optic neuritis.
3. eye ointment prepared by the present invention is added with isotonic agent so that eye ointment can accelerate the suction of skin under massage effect
It receives, improves rate at 3 times or more, while dehydration and the oedema phenomenon of cell will not be caused.
Stem of noble dendrobium eye ointment prepared by the present invention, is made of Chinese medicine preparation, to a variety of eye diseases, has apparent curative effect,
Action time is fast simultaneously, has no toxic side effect.
Specific embodiment
The present invention will be further described With reference to embodiment.
Embodiment 1：
A kind of stem of noble dendrobium eye ointment, by weight component are as follows：5 parts of stone flower, 10 parts of Radix Ophiopogonis, 10 parts of cicada slough, 10 parts of snake slough, Equisetum hiemale Linne
10 parts, 5 parts of cassia seed, 5 parts of the bark of ash, 30 parts of vaseline, 1 part of eucalyptus oil, 1 part of tea oil, 1 part of bacteriostatic agent, 2 parts of conditioning agent, etc.
1 part of penetration enhancer, 5 parts of thickener.
A kind of preparation method of stem of noble dendrobium eye ointment, is as follows：
1）10 parts of Radix Ophiopogonis, 10 parts of cicada slough, 10 parts of snake slough, 10 parts of Equisetum hiemale Linne, 5 parts of cassia seed, 5 parts of the bark of ash are taken, is added after mixing pure
50 parts of water purification, is decocted, and obtained concoction is added on D101 large pore resin absorption columns, is eluted with 20% ethyl alcohol,
20 parts of eluents are collected, then are eluted with 50% ethyl alcohol, 20 parts of eluents are collected, eluent will be depressurized back after mixing twice
Ethyl alcohol is received, takes filtrate spare after filtering；
2）A container is taken, has one layer of latticed baffle, baffle to take 30 parts of stone flower apart from bottom 10cm, be laid in inside container
On baffle, lay thickness is 2cm, and bottom is equipped with 1）In filtrate, container inner pressure is down to 2Kpa, is heated to after container sealing
30 DEG C, fumigate 10min；
3）The stone flower after fumigating is taken out, the particle that 400 mesh are crushed to after drying is spare；
4）30 parts of vaseline, 1 part of eucalyptus oil, 1 part of tea oil are taken, is added in 5 parts of pure water and is heated after mixing, heated
Temperature is 70 DEG C, after vaseline is melted into viscous pasty state, sequentially adds 3）In particle, 1 part of bacteriostatic agent, 2 parts of conditioning agent, etc.
1 part of penetration enhancer, 5 parts of thickener carry out oscillation stirring, and rotating speed 100r/min, natural cooling is air-dried and be can be prepared by after stirring
A kind of stem of noble dendrobium eye ointment.
Wherein, the preparation process of bacteriostatic agent is as follows：
1）5 parts of borneol, 5 parts of folium artemisiae argyi, 5 parts of cloves, 5 parts of blackberry lily are taken, 20 part 50% of ethyl alcohol is added after mixing and carries out centrifugation oscillation,
Hunting power is 200W, duration of oscillation 20min, waits vacuum distillation recycling ethyl alcohol after vibrating, filter is taken after solution is filtered
Liquid is spare；
2）By 1）In filtrate with pure water dilute 5 times can be prepared by.
The preparation process of conditioning agent is as follows：
1）100 parts of pure water is taken, 1 part of anhydrous sodium dihydrogen phosphate is added, vibrates and stirs evenly after mixing, it is spare；
2）100 parts of pure water is taken, 1 part of Anhydrous Disodium Phosphate is added, vibrates and stirs evenly after mixing, it is spare；
3）Take 1）With 2）In solution according to 1:The solution that pH is 6.0 is made in 2 weight proportion.
Isotonic agent is by 0.6% sodium chloride solution and 20% glucose solution according to 1:2 weight proportion is mixed with
's.
Thickener is by methylcellulose, hydroxypropyl methyl cellulose and polysorbate according to 1:1:2 weight proportion is mixed
Conjunction is made viscosity and can be prepared by for 4.0cpa.s.
Embodiment 2：
A kind of stem of noble dendrobium eye ointment, by weight component are as follows：10 parts of stone flower, 15 parts of Radix Ophiopogonis, 20 parts of cicada slough, 15 parts of snake slough, scouring rush
15 parts of grass, 10 parts of cassia seed, 7 parts of the bark of ash, 40 parts of vaseline, 2 parts of eucalyptus oil, 1.5 parts of tea oil, 2 parts of bacteriostatic agent, conditioning agent 3
Part, 3 parts of isotonic agent, 7 parts of thickener.
A kind of preparation method of stem of noble dendrobium eye ointment, is as follows：
1）15 parts of Radix Ophiopogonis, 20 parts of cicada slough, 15 parts of snake slough, 15 parts of Equisetum hiemale Linne, 10 parts of cassia seed, 7 parts of the bark of ash are taken, is added after mixing pure
70 parts of water purification, is decocted, and obtained concoction is added on D101 large pore resin absorption columns, is eluted with 25% ethyl alcohol,
25 parts of eluents are collected, then are eluted with 70% ethyl alcohol, 30 parts of eluents are collected, eluent will be depressurized back after mixing twice
Ethyl alcohol is received, takes filtrate spare after filtering；
2）A container is taken, has one layer of latticed baffle, baffle to take 50 parts of stone flower apart from bottom 12cm, be laid in inside container
On baffle, lay thickness is 3cm, and bottom is equipped with 1）In filtrate, container inner pressure is down to 3Kpa, is heated to after container sealing
35 DEG C, fumigate 20min；
3）The stone flower after fumigating is taken out, the particle that 500 mesh are crushed to after drying is spare；
4）40 parts of vaseline, 2 parts of eucalyptus oil, 1.5 parts of tea oil are taken, is added in 7 parts of pure water and is heated after mixing, added
Hot temperature is 80 DEG C, after vaseline is melted into viscous pasty state, sequentially adds 3）In particle, 2 parts of bacteriostatic agent, 3 parts of conditioning agent,
3 parts of isotonic agent, 7 parts of thickener carry out oscillation stirring, and rotating speed 200r/min, natural cooling is air-dried and can be made after stirring
Obtain a kind of stem of noble dendrobium eye ointment.
Wherein, the preparation process of bacteriostatic agent is as follows：
1）10 parts of borneol, 7 parts of folium artemisiae argyi, 15 parts of cloves, 10 parts of blackberry lily are taken, the ethyl alcohol of 30 part 60% of addition centrifuge and shaken after mixing
It swings, hunting power 300W, duration of oscillation 25min, waits vacuum distillation recycling ethyl alcohol after vibrating, taken after solution is filtered
Filtrate is spare；
2）By 1）In filtrate with pure water dilute 6 times can be prepared by.
The preparation process of conditioning agent is as follows：
1）200 parts of pure water is taken, 2 parts of anhydrous sodium dihydrogen phosphate is added, vibrates and stirs evenly after mixing, it is spare；
2）230 parts of pure water is taken, 2 parts of Anhydrous Disodium Phosphate is added, vibrates and stirs evenly after mixing, it is spare；
3）Take 1）With 2）In solution according to 1.5:The solution that pH is 7 is made in 2.5 weight proportion.
Isotonic agent is by 1.0% sodium chloride solution and 30% glucose solution according to 1.5:2.5 weight proportion mixing
It prepares.
Thickener is by methylcellulose, hydroxypropyl methyl cellulose and polysorbate according to 1.5:2:2.5 weight match
It can be prepared by for 4.5cpa.s than being mixed and made into viscosity.
Embodiment 3：
A kind of stem of noble dendrobium eye ointment, by weight component are as follows：15 parts of stone flower, 20 parts of Radix Ophiopogonis, 30 parts of cicada slough, 25 parts of snake slough, scouring rush
20 parts of grass, 15 parts of cassia seed, 10 parts of the bark of ash, 50 parts of vaseline, 3 parts of eucalyptus oil, 2 parts of tea oil, 3 parts of bacteriostatic agent, conditioning agent 5
Part, 5 parts of isotonic agent, 10 parts of thickener.
A kind of preparation method of stem of noble dendrobium eye ointment, is as follows：
1）20 parts of Radix Ophiopogonis, 30 parts of cicada slough, 25 parts of snake slough, 20 parts of Equisetum hiemale Linne, 15 parts of cassia seed, 10 parts of the bark of ash are taken, is added after mixing
100 parts of pure water, is decocted, and obtained concoction is added on D101 large pore resin absorption columns, is washed with 30% ethyl alcohol
It is de-, 30 parts of eluents are collected, then eluted with 80% ethyl alcohol, collect 40 parts of eluents, eluent will depressurized after mixing twice
Ethyl alcohol is recycled, takes filtrate spare after filtering；
2）A container is taken, has one layer of latticed baffle, baffle to take 80 parts of stone flower apart from bottom 15cm, be laid in inside container
On baffle, lay thickness is 5cm, and bottom is equipped with 1）In filtrate, container inner pressure is down to 5Kpa, is heated to after container sealing
40 DEG C, fumigate 30min；
3）The stone flower after fumigating is taken out, the particle that 600 mesh are crushed to after drying is spare；
4）50 parts of vaseline, 3 parts of eucalyptus oil, 2 parts of tea oil are taken, is added in 10 parts of pure water and is heated after mixing, added
Hot temperature is 90 DEG C, after vaseline is melted into viscous pasty state, sequentially adds 3）In particle, 3 parts of bacteriostatic agent, 5 parts of conditioning agent,
5 parts of isotonic agent, 10 parts of thickener carry out oscillation stirring, and rotating speed 300r/min, natural cooling is air-dried and can be made after stirring
Obtain a kind of stem of noble dendrobium eye ointment.
Wherein, the preparation process of bacteriostatic agent is as follows：
1）15 parts of borneol, 10 parts of folium artemisiae argyi, 20 parts of cloves, 15 parts of blackberry lily are taken, the ethyl alcohol of 50 part 80% of addition centrifuge and shaken after mixing
It swings, hunting power 500W, duration of oscillation 30min, waits vacuum distillation recycling ethyl alcohol after vibrating, taken after solution is filtered
Filtrate is spare；
2）By 1）In filtrate with pure water dilute 8 times can be prepared by.
The preparation process of conditioning agent is as follows：
1）800 parts of pure water is taken, 5 parts of anhydrous sodium dihydrogen phosphate is added, vibrates and stirs evenly after mixing, it is spare；
2）500 parts of pure water is taken, 3 parts of Anhydrous Disodium Phosphate is added, vibrates and stirs evenly after mixing, it is spare；
3）Take 1）With 2）In solution according to 2:The solution that pH is 8 is made in 3 weight proportion.
Isotonic agent is by 1.2% sodium chloride solution and 40% glucose solution according to 2:3 weight proportion is mixed with
's.
Thickener is by methylcellulose, hydroxypropyl methyl cellulose and polysorbate according to 2:3:3 weight proportion is mixed
Conjunction is made viscosity and can be prepared by for 5.0cpa.s.
Experimental example：It is random to select 300 myopias, clinical test is carried out, patient age is put down between 10-50 Sui
At equal 30 years old age, patient is divided into 3 groups, respectively experimental group, control group and blank group.Experimental group patient is carried using embodiment 1
The eye ointment of confession is massaged at eight acupuncture points coated in circumference of eyes, and twice a day, each coating is primary sooner or later；Control group makes
Manually tear eyedrops, twice a day, each drop is primary sooner or later；Blank group patient does eight caves of the eye exercises to circumference of eyes
Position is massaged, and twice a day, once in the morning and once at night, observes patient profiles after a week, record is as shown in Table 1：
Table one
As can be seen from Table I, experimental group patient has 76 people's eyesights to be improved, increase rate 76%, has 24 people's eyesights not change,
, there is not the case where visual impairment in inefficiency 24%；Wherein there are the disappearance of 82 human eye feeling of fatigue, cure rate 82% there are 17 human eyes
Eyeball fatigue is improved, improvement rate 17%, and only 1 people is invalid, inefficiency 1%.Compare control group and blank group, and effect is bright
It is aobvious, therefore eye ointment provided by the invention has the function of curing eye fatigue well, improves eyesight
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, it is any without
That crosses that creative work expects transforms or replaces, and should all cover within the scope of the present invention.
Claims (6)
1. a kind of stem of noble dendrobium eye ointment, which is characterized in that component is as follows by weight：5-15 parts of stone flower, Radix Ophiopogonis 10-20 part, cicada slough
10-30 parts, 10-25 parts of snake slough, 10-20 parts of Equisetum hiemale Linne, 5-15 parts of cassia seed, 5-10 parts of the bark of ash, 30-50 parts of vaseline, eucalyptus
1-3 parts oily, 1-2 parts of tea oil, 1-3 parts of bacteriostatic agent, 2-5 parts of conditioning agent, 1-5 parts of isotonic agent, 5-10 parts of thickener.
2. a kind of stem of noble dendrobium eye ointment as described in claim 1, which is characterized in that the preparation process of bacteriostatic agent is as follows：
1）5-15 parts of borneol, 5-10 parts of folium artemisiae argyi, 5-20 parts of cloves, 5-15 parts of blackberry lily are taken, 20-50 parts of 50-80% of addition after mixing
Ethyl alcohol carries out centrifugation oscillation, hunting power 200-500W, and duration of oscillation 20-30min waits being evaporated under reduced pressure back after vibrating
Ethyl alcohol is received, takes filtrate spare after solution is filtered；
2）By 1）In filtrate with pure water dilute 5-8 times can be prepared by.
3. a kind of stem of noble dendrobium eye ointment as described in claim 1, it is characterised in that the preparation process of conditioning agent is as follows：
1）100-800 parts of pure water is taken, 1-5 parts of anhydrous sodium dihydrogen phosphate is added, vibrates and stirs evenly after mixing, it is spare；
2）100-500 parts of pure water is taken, 1-3 parts of Anhydrous Disodium Phosphate is added, vibrates and stirs evenly after mixing, it is spare；
3）Take 1）With 2）In solution according to 1-2:The solution that pH is 6-8 is made in the weight proportion of 2-3.
4. a kind of stem of noble dendrobium eye ointment as described in claim 1, it is characterised in that isotonic agent is the sodium chloride solution by 0.6-1.2%
Glucose solution with 20-40% is according to 1-2:What the weight proportion of 2-3 was mixed with.
5. a kind of stem of noble dendrobium eye ointment as described in claim 1, it is characterised in that thickener is by methylcellulose, hydroxypropyl methyl
Cellulose and polysorbate are according to 1-2:1-3:The weight proportion of 2-3 is mixed and made into viscosity and can be prepared by for 4.0-5.0cpa.s.
6. a kind of preparation method of stem of noble dendrobium eye ointment as described in claim 1, specific preparation process are as follows：
1）Take Radix Ophiopogonis 10-20 part, 10-30 parts of cicada slough, 10-25 parts of snake slough, 10-20 parts of Equisetum hiemale Linne, 5-15 parts of cassia seed, bark of ash 5-
10 parts, 50-100 parts of pure water is added after mixing, is decocted, obtained concoction is added to D101 large pore resin absorption columns
On, it is eluted with the ethyl alcohol of 20-30%, collects 20-30 parts of eluents, then eluted with the ethyl alcohol of 50-80%, collect 20-
40 parts of eluents will be recovered under reduced pressure ethyl alcohol after mixing by eluent twice, and take filtrate spare after filtering；
2）A container is taken, has one layer of latticed baffle, baffle to take 30-80 parts of stone flower apart from bottom 10-15cm inside container,
It is laid on baffle, lay thickness is 2-5cm, and bottom is equipped with 1）In filtrate, container inner pressure is down to 2-5Kpa, container is close
It is honored as a queen and is heated to 30-40 DEG C, fumigate 10-30min；
3）The stone flower after fumigating is taken out, the particle that 400-600 mesh is crushed to after drying is spare；
4）Take 30-50 parts of vaseline, 1-3 parts of eucalyptus oil, 1-2 parts of tea oil, after mixing be added 5-10 parts of pure water in into
Row heating, heating temperature are 70-90 DEG C, after vaseline is melted into viscous pasty state, sequentially add 3）In particle, bacteriostatic agent 1-
3 parts, 2-5 parts of conditioning agent, 1-5 parts of isotonic agent, 5-10 parts of thickener, carry out oscillation stirring, rotating speed 100-300r/min, stirring
After natural cooling air-dry can be prepared by a kind of stem of noble dendrobium eye ointment.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102648968A (en) * | 2011-02-26 | 2012-08-29 | 晏素琼 | External traditional Chinese medicine composition for eye health |
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| CN102648968A (en) * | 2011-02-26 | 2012-08-29 | 晏素琼 | External traditional Chinese medicine composition for eye health |
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Application publication date: 20180914 |