A kind of medical dressing and preparation method thereof for external Wound care
Technical field:
The present invention relates to medical material preparation fields, are specifically related to a kind of medical dressing for external Wound care.
Background technology:
Covering of the medical dressing as wound can substitute impaired skin and play temporarily in wound healing process
The barrier action of when property avoids or controls wound infection, is provided with the environment conducive to wound healing.With the aging of population and slowly
The exedens wound of property increases, and the market value of medical dressing also becomes more and more important.
Novel medical dressing is divided into film class, Hydrogels, alginic acid salt, foam class, hydrocolloid class, medicinal class dressing.
Film class dressing is transparent, convenient for observation wound, can attach to surface of a wound surface closely, effectively keep wound fluid, provides advantageous
In the moist environment of wound healing, slough is promoted to fall off, mitigate surface of a wound pain, disadvantage is that water absorbing properties are not good enough.Hydrogel
Class dressing can reduce bacteria breed with the surface of a wound close adhesion of out-of-flatness, and new vessels is accelerated to generate, and promote epithelial cell life
It is long.Hydrocolloid class dressing many thicker than film class dressing, the thickness of glue-line determine that the size of its absorbability, bearing hydrocolloid dressing can
It absorbs on a small quantity to middle amount sepage, is not suitable for the surface of a wound more than diffusate.Foam class dressing has porosity, and surface tension is low, rich
Flexible, plasticity is strong, light, strong to the absorbability of diffusate, almost penetrating to oxygen and carbon dioxide, can be used as medicine
Object carrier.Novel alginic acid salt dressing is softer, is easy to fold, and application is convenient, and soft similar gels are formed on the surface of a wound
Semi-solid material provides a moist environment for the surface of a wound, improves the power of regeneration of epidermal cell, accelerates epidermal cell movement, but
It is that its adhesiveness is poor.Medicinal class dressing has the protection surface of a wound, analgesic, hemostasis, anti-inflammatory, promotes new granulation tissue and epithelial cell
Growth accelerates the functions such as wound healing.
Invention content:
In view of the deficiencies of the prior art, it is an object of the present invention to provide a kind of medical dressing for external Wound care,
The dressing has higher porosity and gas permeability, can effectively facilitate wound healing, and have certain anti-microbial property.
It is a further object to provide the preparation methods of the medical dressing.
To achieve the above object, the present invention uses following technical scheme:
A kind of medical dressing for external Wound care, the medical dressing are made of two shell fabrics, and outer shell fabric is
Polyester fabric, fabric are the fiber weavings by nucleocapsid, and the fiber of the nucleocapsid is using sodium alginate dimension as core, outside
Bread is covered with polyacrylate.
A kind of preparation method of medical dressing for external Wound care, includes the following steps:
(1) sodium alginate is prepared by raw material of kelp, alginic acid fibre is then prepared using electrostatic spinning process;
(2) ethyl acrylate, butyl acrylate and deionized water are mixed, emulsifier are then added, stirs evenly,
It is to slowly warm up to 50-60 DEG C, initiator is added, is stirred to react 10-30min, is cooled to room temperature after reaction, polypropylene is made
Acid esters lotion;
(3) alginic acid fibre is cleaned up using deionized water, is added to after using plasma processing activation above-mentioned
In polyacrylate dispersion obtained, silane coupling agent is then added, 1-4h is stirred to react at 60-80 DEG C, after reaction,
Modified alginic acid fibre is made in filtering;
(4) alginic acid fibre obtained above is combed into networking, then uses needling process that non-woven cloth is made, it will be above-mentioned
Polyester fabric and non-woven cloth are sequentially placed into hot press, and gelatin particle is added between two shell fabrics, and hot-pressing processing is made and applies
Material.
As a preferred embodiment of the above technical solution, in step (2), the emulsifier is cetyl trimethylammonium bromide.
As a preferred embodiment of the above technical solution, in step (2), the initiator is potassium peroxydisulfate.
As a preferred embodiment of the above technical solution, in step (2), each component dosage in parts by weight, respectively acrylic acid second
15-28 parts of ester, 10-15 parts of butyl acrylate, 10-20 parts of deionized water, 0.5-1 parts of emulsifier, 1-2 parts of initiator.
As a preferred embodiment of the above technical solution, in step (3), the time of the corona treatment is 5-10min.
As a preferred embodiment of the above technical solution, in step (3), polyacrylate dispersion, silane coupling agent, alginic acid fibre
Mass ratio be (13-17):(0.1-0.3):5.
As a preferred embodiment of the above technical solution, in step (4), it is 120-150 DEG C that the condition of the hot pressing, which is temperature,
Hot pressing time is 5-15min.
As a preferred embodiment of the above technical solution, in step (4), sterilization treatment is also carried out after hot-pressing processing.
As a preferred embodiment of the above technical solution, in step (4), it is 110- that the condition of the sterilization treatment, which is sterilising temp,
130 DEG C, sterilization time 1-2h.
The invention has the advantages that:
Dressing produced by the present invention is coated with by polyester fabric and surface made from the alginic acid fibre of polyacrylate
Fabric forms, and as surface layer, hydrophobicity is good on terylene surface, the internal layer good water absorption made from alginic acid fibre, in order to improve
Its flexibility and intensity, the method comprises the steps of firstly, preparing poly- polyacrylate dispersions, then carry out plasma work to alginic acid fibre
Change and alginic acid fibre surface is made to carry crosslinkable groups, it is cross-linking under the action of silane coupling agent to be coated with polyacrylic acid
Ester, the advantages of not only having maintained alginic acid fibre good hygroscopicity, but also improve the flexibility and intensity of alginic acid fibre;
After testing, the penetrability of dressing produced by the present invention is 80g/ (hcm2) more than, gas permeability 293-305L/
(s·m2)。
Specific implementation mode:
In order to better understand the present invention, below by embodiment, the present invention is further described, and embodiment is served only for solving
The present invention is released, any restriction will not be constituted to the present invention.
Embodiment 1
A kind of medical dressing for external Wound care, the medical dressing are made of two shell fabrics, and outer shell fabric is
Polyester fabric, fabric are the fiber weavings by nucleocapsid, and the fiber of the nucleocapsid is using sodium alginate dimension as core, outside
Bread is covered with polyacrylate;
Preparation method includes the following steps:
(1) sodium alginate is prepared by raw material of kelp, alginic acid fibre is then prepared using electrostatic spinning process;
(2) ethyl acrylate, butyl acrylate and deionized water are mixed, cetyl trimethyl bromine is then added
Change ammonium, stir evenly, be to slowly warm up to 50-60 DEG C, potassium peroxydisulfate is added, is stirred to react 10min, is cooled to room after reaction
Polyacrylate dispersion is made in temperature;Wherein, each component dosage in parts by weight, respectively 15 parts of ethyl acrylate, acrylic acid fourth
10 parts of ester, 10 parts of deionized water, 0.5 part of cetyl trimethylammonium bromide, 1 part of potassium peroxydisulfate;
(3) alginic acid fibre is cleaned up using deionized water, is added to after using plasma processing activation 5min
In polyacrylate dispersion obtained above, silane coupling agent is then added, 1h is stirred to react at 60 DEG C, after reaction,
Modified alginic acid fibre is made in filtering;Wherein, polyacrylate dispersion, silane coupling agent, alginic acid fibre mass ratio be
13:0.1:5;
(4) alginic acid fibre obtained above is combed into networking, then uses needling process that non-woven cloth is made, it will be above-mentioned
Polyester fabric and non-woven cloth are sequentially placed into hot press, are added gelatin particle between two shell fabrics, hot-pressing processing at 120 DEG C
5min, finally sterilize at 110 DEG C 1h, and dressing is made.
Embodiment 2
A kind of medical dressing for external Wound care, the medical dressing are made of two shell fabrics, and outer shell fabric is
Polyester fabric, fabric are the fiber weavings by nucleocapsid, and the fiber of the nucleocapsid is using sodium alginate dimension as core, outside
Bread is covered with polyacrylate;
Preparation method includes the following steps:
(1) sodium alginate is prepared by raw material of kelp, alginic acid fibre is then prepared using electrostatic spinning process;
(2) ethyl acrylate, butyl acrylate and deionized water are mixed, cetyl trimethyl bromine is then added
Change ammonium, stir evenly, be to slowly warm up to 50-60 DEG C, potassium peroxydisulfate is added, is stirred to react 30min, is cooled to room after reaction
Polyacrylate dispersion is made in temperature;Wherein, each component dosage in parts by weight, respectively 28 parts of ethyl acrylate, acrylic acid fourth
15 parts of ester, 20 parts of deionized water, 1 part of cetyl trimethylammonium bromide, 2 parts of potassium peroxydisulfate;
(3) alginic acid fibre is cleaned up using deionized water, is added to after using plasma processing activation 10min
In polyacrylate dispersion obtained above, silane coupling agent is then added, 4h is stirred to react at 80 DEG C, after reaction,
Modified alginic acid fibre is made in filtering;Wherein, polyacrylate dispersion, silane coupling agent, alginic acid fibre mass ratio be
17:0.3:5;
(4) alginic acid fibre obtained above is combed into networking, then uses needling process that non-woven cloth is made, it will be above-mentioned
Polyester fabric and non-woven cloth are sequentially placed into hot press, are added gelatin particle between two shell fabrics, hot-pressing processing at 150 DEG C
15min, finally sterilize at 130 DEG C 2h, and dressing is made.
Embodiment 3
A kind of medical dressing for external Wound care, the medical dressing are made of two shell fabrics, and outer shell fabric is
Polyester fabric, fabric are the fiber weavings by nucleocapsid, and the fiber of the nucleocapsid is using sodium alginate dimension as core, outside
Bread is covered with polyacrylate;
Preparation method includes the following steps:
(1) sodium alginate is prepared by raw material of kelp, alginic acid fibre is then prepared using electrostatic spinning process;
(2) ethyl acrylate, butyl acrylate and deionized water are mixed, cetyl trimethyl bromine is then added
Change ammonium, stir evenly, be to slowly warm up to 50-60 DEG C, potassium peroxydisulfate is added, is stirred to react 15min, is cooled to room after reaction
Polyacrylate dispersion is made in temperature;Wherein, each component dosage in parts by weight, respectively 17 parts of ethyl acrylate, acrylic acid fourth
11 parts of ester, 12 parts of deionized water, 0.6 part of cetyl trimethylammonium bromide, 1.2 parts of potassium peroxydisulfate;
(3) alginic acid fibre is cleaned up using deionized water, is added to after using plasma processing activation 5min
In polyacrylate dispersion obtained above, silane coupling agent is then added, 2h is stirred to react at 65 DEG C, after reaction,
Modified alginic acid fibre is made in filtering;Wherein, polyacrylate dispersion, silane coupling agent, alginic acid fibre mass ratio be
14:0.2:5;
(4) alginic acid fibre obtained above is combed into networking, then uses needling process that non-woven cloth is made, it will be above-mentioned
Polyester fabric and non-woven cloth are sequentially placed into hot press, are added gelatin particle between two shell fabrics, hot-pressing processing at 130 DEG C
7min, finally sterilize at 115 DEG C 1.2h, and dressing is made.
Embodiment 4
A kind of medical dressing for external Wound care, the medical dressing are made of two shell fabrics, and outer shell fabric is
Polyester fabric, fabric are the fiber weavings by nucleocapsid, and the fiber of the nucleocapsid is using sodium alginate dimension as core, outside
Bread is covered with polyacrylate;
Preparation method includes the following steps:
(1) sodium alginate is prepared by raw material of kelp, alginic acid fibre is then prepared using electrostatic spinning process;
(2) ethyl acrylate, butyl acrylate and deionized water are mixed, cetyl trimethyl bromine is then added
Change ammonium, stir evenly, be to slowly warm up to 50-60 DEG C, potassium peroxydisulfate is added, is stirred to react 20min, is cooled to room after reaction
Polyacrylate dispersion is made in temperature;Wherein, each component dosage in parts by weight, respectively 20 parts of ethyl acrylate, acrylic acid fourth
12 parts of ester, 14 parts of deionized water, 0.7 part of cetyl trimethylammonium bromide, 1.4 parts of potassium peroxydisulfate;
(3) alginic acid fibre is cleaned up using deionized water, is added to after using plasma processing activation 10min
In polyacrylate dispersion obtained above, silane coupling agent is then added, 3h is stirred to react at 70 DEG C, after reaction,
Modified alginic acid fibre is made in filtering;Wherein, polyacrylate dispersion, silane coupling agent, alginic acid fibre mass ratio be
15:0.2:5;
(4) alginic acid fibre obtained above is combed into networking, then uses needling process that non-woven cloth is made, it will be above-mentioned
Polyester fabric and non-woven cloth are sequentially placed into hot press, are added gelatin particle between two shell fabrics, hot-pressing processing at 140 DEG C
9min, finally sterilize at 110-130 DEG C 1.4h, and dressing is made.
Embodiment 5
A kind of medical dressing for external Wound care, the medical dressing are made of two shell fabrics, and outer shell fabric is
Polyester fabric, fabric are the fiber weavings by nucleocapsid, and the fiber of the nucleocapsid is using sodium alginate dimension as core, outside
Bread is covered with polyacrylate;
Preparation method includes the following steps:
(1) sodium alginate is prepared by raw material of kelp, alginic acid fibre is then prepared using electrostatic spinning process;
(2) ethyl acrylate, butyl acrylate and deionized water are mixed, cetyl trimethyl bromine is then added
Change ammonium, stir evenly, be to slowly warm up to 50-60 DEG C, potassium peroxydisulfate is added, is stirred to react 20min, is cooled to room after reaction
Polyacrylate dispersion is made in temperature;Wherein, each component dosage in parts by weight, respectively 22 parts of ethyl acrylate, acrylic acid fourth
13 parts of ester, 16 parts of deionized water, 0.7 part of cetyl trimethylammonium bromide, 1.6 parts of potassium peroxydisulfate;
(3) alginic acid fibre is cleaned up using deionized water, is added to after using plasma processing activation 10min
In polyacrylate dispersion obtained above, silane coupling agent is then added, 3h is stirred to react at 70 DEG C, after reaction,
Modified alginic acid fibre is made in filtering;Wherein, polyacrylate dispersion, silane coupling agent, alginic acid fibre mass ratio be
15:0.2:5;
(4) alginic acid fibre obtained above is combed into networking, then uses needling process that non-woven cloth is made, it will be above-mentioned
Polyester fabric and non-woven cloth are sequentially placed into hot press, are added gelatin particle between two shell fabrics, hot-pressing processing at 130 DEG C
10min, finally sterilize at 120 DEG C 1.6h, and dressing is made.
Embodiment 6
A kind of medical dressing for external Wound care, the medical dressing are made of two shell fabrics, and outer shell fabric is
Polyester fabric, fabric are the fiber weavings by nucleocapsid, and the fiber of the nucleocapsid is using sodium alginate dimension as core, outside
Bread is covered with polyacrylate;
Preparation method includes the following steps:
(1) sodium alginate is prepared by raw material of kelp, alginic acid fibre is then prepared using electrostatic spinning process;
(2) ethyl acrylate, butyl acrylate and deionized water are mixed, cetyl trimethyl bromine is then added
Change ammonium, stir evenly, be to slowly warm up to 50-60 DEG C, potassium peroxydisulfate is added, is stirred to react 25min, is cooled to room after reaction
Polyacrylate dispersion is made in temperature;Wherein, each component dosage in parts by weight, respectively 26 parts of ethyl acrylate, acrylic acid fourth
14 parts of ester, 18 parts of deionized water, 0.9 part of cetyl trimethylammonium bromide, 1.8 parts of potassium peroxydisulfate;
(3) alginic acid fibre is cleaned up using deionized water, is added to after using plasma processing activation 10min
In polyacrylate dispersion obtained above, silane coupling agent is then added, 3.5h is stirred to react at 75 DEG C, reaction terminates
Afterwards, it filters, modified alginic acid fibre is made;Wherein, the mass ratio of polyacrylate dispersion, silane coupling agent, alginic acid fibre
It is 16:0.25:5;
(4) alginic acid fibre obtained above is combed into networking, then uses needling process that non-woven cloth is made, it will be above-mentioned
Polyester fabric and non-woven cloth are sequentially placed into hot press, are added gelatin particle between two shell fabrics, hot-pressing processing at 140 DEG C
10min, finally sterilize at 125 DEG C 1.8h, and dressing is made.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.