CN108498387B - Plant composite peptide and preparation method thereof - Google Patents
Plant composite peptide and preparation method thereof Download PDFInfo
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- CN108498387B CN108498387B CN201810495895.9A CN201810495895A CN108498387B CN 108498387 B CN108498387 B CN 108498387B CN 201810495895 A CN201810495895 A CN 201810495895A CN 108498387 B CN108498387 B CN 108498387B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
Abstract
The invention discloses a plant composite peptide, which consists of the following raw materials in parts by weight: 40-50 parts of tremella, 40-50 parts of agaric, 40-50 parts of black tea fungus and 5-10 parts of calcium aspartate. The application provides a plant composite peptide to the micromolecular peptide that auricularia auriculajudae, tremella and black tea fungus were made is the principal ingredients, and above-mentioned three kinds of compositions have the effect of gain in coordination, when the cooperation is used, and is amazing safe to skin, for the cell provides deep moisturizing, has better moisturizing, anti-wrinkle effect, can show improvement skin state, still promotes the absorption of skin to the micromolecular peptide through adding calcium aspartate. The application also provides a preparation method of the plant composite peptide, which has the characteristics of simple operation and convenience for batch production.
Description
Technical Field
The invention relates to the field of health care products, in particular to a plant composite peptide and a preparation method thereof.
Background
The small molecule active peptide is a biochemical substance between amino acid and protein, has a molecular weight smaller than that of the protein and larger than that of the amino acid, and is a fragment of the protein. Two or more amino acids are linked by peptide bonds to form an "amino acid chain" or "amino acid string" called a peptide. Among them, peptides consisting of 10 to 15 or more amino acids are called polypeptides, peptides consisting of 2 to 9 amino acids are called oligopeptides, and peptides consisting of 2 to 15 amino acids are called small peptides or small peptides. Small molecule peptides are increasingly used as cosmetics because of their remarkable effects in the field of skin repair, but most of the small molecule peptide raw materials on the market are synthetic products, and their activities are obviously lower than those of natural products.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide the plant composite peptide which has a better cell repairing effect and has a remarkable effect on whitening and anti-wrinkle of skin.
The second object of the present invention is to provide a method for preparing the above-mentioned plant complex peptide.
One of the purposes of the invention is realized by adopting the following technical scheme:
a plant composite peptide is composed of the following raw materials in parts by weight: 40-50 parts of tremella, 40-50 parts of agaric, 40-50 parts of black tea fungus and 5-10 parts of calcium aspartate.
Further comprises purified water, and the using amount of the purified water is 150-200 parts.
Further, the feed additive comprises the following raw materials in parts by weight: 45 parts of tremella, 45 parts of agaric, 45 parts of black tea fungus, 10 parts of calcium aspartate and 150 parts of purified water.
The second purpose of the invention is realized by adopting the following technical scheme:
the preparation method of the plant composite peptide comprises the following steps:
(1) removing impurities: sorting edible fungus, tremella and black tea fungus to remove impurities;
(2) fermentation: fermenting the agaric, the tremella and the black tea fungus which are subjected to impurity removal under an anaerobic condition to obtain a mixture of tremella peptide, agaric peptide and black tea fungus peptide;
(3) and (3) drying: drying the fermented mixed material until the water content is less than or equal to 8 percent
(4) Superfine grinding: adding calcium aspartate into the dried mixture in the step (3) for superfine grinding;
(5) and (3) sterilization: adding purified water into the mixture obtained in the step (3), uniformly mixing, and then sterilizing by adopting ozone;
(6) filling: and filling and sealing the sterilized plant composite peptide to obtain a finished product.
Further, the fermentation temperature in the step (2) is 35-40 ℃, and the fermentation time is 35-40 h.
Further, the drying temperature in the step (3) is 55-60 ℃, and the drying time is 30-40 min.
Further, the step (4) is performed until the particle fineness is 800-100 meshes.
Further, the amount of ozone added in the step (5) is 10 g/h.
Further, the step (2), the step (3), the step (4), the step (5) and the step (6) in the method are all completed in a D-grade clean zone, the external environment temperature is 18-26 ℃, and the humidity is 45-65%.
Compared with the prior art, the invention has the beneficial effects that: the application provides a plant composite peptide uses the micromolecular peptide that auricularia auriculajudae, tremella and black tea fungus fermentation made as the principal ingredients, and above-mentioned three kinds of compositions have the effect of gain in coordination, when the cooperation is used, and is safe to skin not have stimulation, for the cell provides deep moisturizing, has better moisturizing, anti-wrinkle effect, can show improvement skin state, still promotes the absorption of skin to the micromolecular peptide through adding calcium aspartate. The application also provides a preparation method of the plant composite peptide, which has the characteristics of simple operation and convenience for batch production.
Detailed Description
The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment.
Example 1
The plant composite peptide consists of the following raw materials in parts by weight: 45 parts of tremella, 45 parts of agaric, 45 parts of black tea fungus, 10 parts of calcium aspartate and 150 parts of purified water.
The preparation method of the plant composite peptide comprises the following steps:
(1) removing impurities: sorting edible fungus, tremella and black tea fungus to remove impurities;
(2) fermentation: fermenting the agaric, the tremella and the black tea fungus which are subjected to impurity removal for 40h at 35 ℃ under an anaerobic condition;
(3) drying the fermented Auricularia peptide, Tremella peptide and black tea fungus peptide at 55 deg.C for 40min until the water content is less than or equal to 8%;
(4) adding calcium aspartate into the mixture fermented in the step (3) and carrying out superfine grinding until the particle fineness is 80 meshes;
(5) adding purified water into the mixture obtained in the step (4), uniformly mixing, and then sterilizing by adopting ozone, wherein the ozone introducing speed is 10 g/h;
(6) and filling and sealing the sterilized plant composite peptide to obtain a finished product.
The step (2), the step (3), the step (4), the step (5) and the step (6) in the method are all completed in a D-level clean area, the external environment temperature is 18 ℃, and the humidity is 45%.
Example 2
The plant composite peptide consists of the following raw materials in parts by weight: 40 parts of tremella, 40 parts of agaric, 40 parts of black tea fungus, 5 parts of calcium aspartate and 180 parts of purified water.
The preparation method of the plant composite peptide comprises the following steps:
(1) removing impurities: sorting edible fungus, tremella and black tea fungus to remove impurities;
(2) fermentation: fermenting the agaric, the tremella and the black tea fungus which are subjected to impurity removal for 36 hours at 38 ℃ under an anaerobic condition;
(3) drying the mixture of Auricularia peptide, Tremella peptide and black tea fungus peptide at 58 deg.C for 35min until the water content is less than 8%
(4) Adding calcium aspartate into the mixture fermented in the step (3) and carrying out superfine grinding until the particle fineness is 90 meshes;
(5) adding purified water into the mixture obtained in the step (4), uniformly mixing, and then sterilizing by adopting ozone, wherein the ozone introducing speed is 10 g/h;
(6) and filling and sealing the sterilized plant composite peptide to obtain a finished product.
The steps (2), (3), (4), (5) and (6) in the method are all completed in a D-level clean area, the external environment temperature is 20 ℃, and the humidity is 50%.
Example 3
The plant composite peptide consists of the following raw materials in parts by weight: 50 parts of tremella, 50 parts of agaric, 50 parts of black tea fungus, 10 parts of calcium aspartate and 200 parts of purified water.
The preparation method of the plant composite peptide comprises the following steps:
(1) removing impurities: sorting edible fungus, tremella and black tea fungus to remove impurities;
(2) fermentation: fermenting the agaric, the tremella and the black tea fungus which are subjected to impurity removal for 35 hours at 40 ℃ under an anaerobic condition;
(3) drying the mixture of Auricularia peptide, Tremella peptide and black tea fungus peptide at 60 deg.C for 30min until the water content is less than or equal to 8%;
(4) adding calcium aspartate into the mixture fermented in the step (3) and carrying out superfine grinding until the particle fineness is 100 meshes;
(5) adding purified water into the mixture obtained in the step (4), uniformly mixing, and then sterilizing by adopting ozone, wherein the ozone introducing speed is 10 g/h;
(6) and filling and sealing the sterilized plant composite peptide to obtain a finished product.
The step (2), the step (3), the step (4), the step (5) and the step (6) in the method are all completed in a D-level clean area, the external environment temperature is 26 ℃, and the humidity is 65%.
Comparative example 1
Comparative example 1 provides a plant composite peptide, which is different from example 1 in that tremella is omitted, the total amount of agaric and black tea fungus is adjusted to 135 parts, and the rest is the same as example 1.
Comparative example 2
Comparative example 2 provides a plant composite peptide, which is different from example 1 in that agaric is omitted, the total amount of tremella and black tea fungus is adjusted to 135 parts, and the rest is the same as example 1.
Comparative example 3
Comparative example 3 provides a plant composite peptide, which is different from example 1 in that black tea fungus is omitted, the total amount of agaric and tremella is adjusted to 135 parts, and the rest is the same as example 1.
Comparative example 4
Comparative example 4 provides a plant composite peptide, which is different from example 1 in that calcium aspartate is replaced with calcium chloride, and the rest is the same as example 1.
Comparative example 5
Comparative example 5 provides a plant composite peptide, which is different from example 1 in that calcium aspartate is replaced with calcium gluconate, and the rest is the same as example 1.
Performance detection
Skin irritation test: 180 female volunteers were selected and divided into 3 groups of 60 in each of examples 1 to 3, and the plant composite peptides obtained in examples 1, 2 and 3 according to the present invention were administered, 0.1g of the sample was placed in a chamber of a spot test tape, and the spot test tape with the sample placed therein was immediately attached to the normal skin of the left forearm from the lower part in the longitudinal direction while gently pressing the chamber one by one to expel the air and uniformly distribute the test substances. The test site is marked for easy observation. The patch was applied once every 24 hours and then peeled off for a half hour, and the patch was examined in accordance with the CTFA guideline terms for 6 patch tests, and on the 7 th day after the completion of the patch, additional examination was performed to observe delayed reactions. The results of the last examination were compared and are shown in tables 1 and 2 below.
TABLE 1 evaluation of skin irritation test identification criteria
| Grade | Symbol | Identification criteria |
| 0 | - | Negative reaction: has no irritation and erythema |
| 1 | ± | And (3) suspicious reaction: mild erythema |
| 2 | + | Weak positive reaction: erythema |
| 3 | ++ | Strong positive reaction: erythema, papules, blisters |
TABLE 2
| Number of times of skin sticking | Example 1 | Example 2 | Example 3 |
| 1 | - | - | - |
| 2 | - | - | - |
| 3 | - | - | - |
| 4 | - | - | - |
| 5 | - | - | - |
| 6 | - | - | - |
| 7 th day after completion | - | - | - |
The detection data show that the composite plant peptide provided by the invention has no positive reaction in the test process, and the skin irritation level is 0, which indicates that the composite plant peptide provided by the invention is mild, safe and non-irritant to skin.
And (3) detecting the moisturizing effect: and (3) detecting the moisturizing effect of the composite plant peptide by using a digital skin moisture tester (SK-IV). 0.05g of the complex vegetable peptide prepared in example 1 and comparative examples 1 to 5 was applied to the inside of the arm in a test area of 3 cm. times.3 cm, respectively, and the results were expressed as an average of the moisture content of skin at 6 times, and are shown in Table 3.
TABLE 3
| Group of | Base value | 1 hour | 2 hours | 4 hours |
| Example 1 | 27.32％ | 52.38％ | 50.15％ | 48.32％ |
| Comparative example 1 | 27.87％ | 38.45％ | 35.78％ | 30.87％ |
| Comparative example 2 | 27.99％ | 37.69％ | 32.47％ | 31.65％ |
| Comparative example 3 | 28.23％ | 38.76％ | 34.22％ | 32.71％ |
| Comparative example 4 | 27.67％ | 45.12％ | 44.78％ | 41.21％ |
| Comparative example 5 | 27.55％ | 44.88％ | 43.23％ | 41.62％ |
As can be seen from table 3, the plant composite peptide of example 1 has a good moisturizing effect, the moisture content of the skin is high after use, and the retention time is long, and comparative examples 1 to 3 omit one of the agaric peptide, the tremella peptide and the black tea fungus peptide, and even if the amounts of other components are increased, the plant composite peptide of the present application still has a moisturizing effect superior to that of the plant composite peptide of the present application, which indicates that the agaric peptide, the tremella peptide and the black tea fungus peptide in the plant composite peptide of the present application have a mutual gain effect after being compounded, and when one of the components is omitted, the synergistic effect among the components disappears, and the effect is significantly reduced. In comparative examples 4 and 5, the calcium aspartate is replaced by calcium chloride or calcium gluconate, and although the moisturizing effect is better than that of comparative examples 1 to 3, the moisturizing effect is obviously inferior to that of example 1, which shows that the calcium aspartate is adopted to effectively promote the absorption of the plant composite peptide by the skin and prolong the moisturizing time.
125 subjects with dry and astringent skin, dark color and severe pigmentation were tried for 1 month and divided into 5 groups of 25 subjects, and the effects of the phytopeptides provided in example 1 and comparative examples 1 to 5 were externally applied to the subjects, respectively, to observe the effects.
TABLE 4 evaluation criteria for skin improvement
TABLE 5
| Group of | Show effect | Is effective | Invalidation |
| Example 1 | 25 | 0 | 0 |
| Comparative example 1 | 12 | 11 | 2 |
| Comparative example 2 | 10 | 14 | 2 |
| Comparative example 3 | 11 | 13 | 1 |
| Comparative example 4 | 15 | 10 | 0 |
| Comparative example 5 | 14 | 11 | 0 |
It can be seen from table 5 that the plant composite peptides provided by the invention all have significant effects after being used, can obviously brighten skin color, and enable skin to be tender and glossy, and have light fine lines, and only part of comparative examples 1 to 3 have significant effects, which shows that one of agaric, tremella and black tea fungus omits the synergistic gain effect and disappears, so that the water supplementing and anti-wrinkle effects of the agaric, tremella and black tea fungus are deteriorated when the plant composite peptides are used, the application is inferior to example 1 in the aspect of improving skin after calcium aspartate is replaced by calcium chloride or calcium gluconate, and shows that calcium aspartate can promote the skin to absorb small peptides of agaric peptides, tremella peptides and black tea fungus peptides, and the effects disappear after the plant composite peptides are replaced by other calcium agents.
According to the test results, the plant composite peptide powder provided by the application is prepared by fermenting the agaric, the tremella and the black tea fungus serving as raw materials into the small molecular peptide, and the comparative example shows that the moisturizing and anti-wrinkle effects are poor after any one of the components is omitted, so that the three components have synergistic effects in the plant composite peptide.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (7)
1. The plant composite peptide is characterized by comprising the following raw materials in parts by weight: 40-50 parts of tremella, 40-50 parts of agaric, 40-50 parts of black tea fungus, 5-10 parts of calcium aspartate and 200 parts of purified water 150-;
the preparation method of the plant composite peptide comprises the following steps:
(1) removing impurities: sorting edible fungus, tremella and black tea fungus to remove impurities;
(2) fermentation: fermenting the agaric, the tremella and the black tea fungus which are subjected to impurity removal under an anaerobic condition to obtain a mixture of tremella peptide, agaric peptide and black tea fungus peptide;
(3) and (3) drying: drying the fermented mixed material until the water content is less than or equal to 8%;
(4) superfine grinding: adding calcium aspartate into the dried mixture in the step (3) for superfine grinding;
(5) and (3) sterilization: adding purified water into the mixture obtained in the step (3), uniformly mixing, and then sterilizing by adopting ozone;
(6) filling: and filling and sealing the sterilized plant composite peptide to obtain a finished product.
2. The plant composite peptide as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 45 parts of tremella, 45 parts of agaric, 45 parts of black tea fungus, 10 parts of calcium aspartate and 150 parts of purified water.
3. The phytocomplex peptide according to claim 1, wherein the fermentation temperature in the step (2) is 35-40 ℃ and the fermentation time is 35-40 hours.
4. The phytocomplex peptide according to claim 1, wherein the drying temperature in the step (3) is 55-60 ℃ for 30-40 min.
5. The plant composite peptide according to claim 1, wherein the grinding in the step (4) is carried out to a particle fineness of 80 to 100 mesh.
6. The phytocomplex peptide according to claim 1, wherein the amount of ozone added in the step (5) is 10 g/h.
7. The plant composite peptide according to claim 1, wherein the steps (2), (3), (4), (5) and (6) in the above method are all completed in a class D clean zone, the external environment temperature is 18-26 ℃, and the humidity is 45-65%.
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| CN201810495895.9A CN108498387B (en) | 2018-05-22 | 2018-05-22 | Plant composite peptide and preparation method thereof |
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| CN201810495895.9A CN108498387B (en) | 2018-05-22 | 2018-05-22 | Plant composite peptide and preparation method thereof |
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| CN108498387B true CN108498387B (en) | 2020-11-06 |
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| CN115804455A (en) * | 2021-09-14 | 2023-03-17 | 锐肽生物科技(大连)集团股份有限公司 | Preparation method of organic sea-buckthorn auricularia auricula active small-molecular peptide liquid |
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| CN101209096A (en) * | 2006-12-31 | 2008-07-02 | 中国科学院过程工程研究所 | Edible porridge and preparation method thereof |
| CN103734694B (en) * | 2013-11-21 | 2016-01-27 | 威海百合生物技术股份有限公司 | A kind of Calcium-supplementinhealth health food and preparation method thereof |
| CN105533351A (en) * | 2016-01-08 | 2016-05-04 | 黑龙江省聚拢乾坤农业技术开发有限公司 | Black fungus health-care beverage and production technology thereof |
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