CN108495927A - 嵌合抗原受体相关的方法和组合物 - Google Patents

嵌合抗原受体相关的方法和组合物 Download PDF

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CN108495927A
CN108495927A CN201680079790.4A CN201680079790A CN108495927A CN 108495927 A CN108495927 A CN 108495927A CN 201680079790 A CN201680079790 A CN 201680079790A CN 108495927 A CN108495927 A CN 108495927A
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protein interaction
cells
polypeptide
cell
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威尔逊·翁
赵章桓
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Boston University
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/23—On/off switch
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding

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CN201680079790.4A 2015-11-23 2016-11-22 嵌合抗原受体相关的方法和组合物 Pending CN108495927A (zh)

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US201562258712P 2015-11-23 2015-11-23
US62/258,712 2015-11-23
PCT/US2016/063257 WO2017091546A1 (en) 2015-11-23 2016-11-22 Methods and compositions relating to chimeric antigen receptors

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CN108495927A true CN108495927A (zh) 2018-09-04

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US (2) US11530252B2 (https=)
EP (1) EP3380602A4 (https=)
JP (1) JP7621053B2 (https=)
KR (2) KR20180075689A (https=)
CN (1) CN108495927A (https=)
HK (1) HK1259190A1 (https=)
WO (1) WO2017091546A1 (https=)

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CN110151999A (zh) * 2019-05-22 2019-08-23 中国人民解放军第四军医大学 用于抑制恶性黑色素瘤进展的靶向药物
CN111234033A (zh) * 2020-01-21 2020-06-05 南京北恒生物科技有限公司 多链嵌合抗原受体及其用途
CN111454909A (zh) * 2019-01-22 2020-07-28 北京大学深圳研究生院 天然配体介导的多靶点识别可调控基因工程化免疫细胞的制备方法
WO2021143826A1 (zh) * 2020-01-17 2021-07-22 信达生物制药(苏州)有限公司 重组抗程序性死亡受体1和抗分化抗原簇137双特异性抗体制剂及其用途
CN115175935A (zh) * 2019-10-18 2022-10-11 波士顿大学董事会 Cal-t构建体及其用途

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CN115052887B (zh) 2019-12-11 2026-03-31 A2生物治疗公司 基于lilrb1的嵌合抗原受体
WO2021156277A1 (en) 2020-02-04 2021-08-12 Miltenyi Biotec B.V. & Co. KG Immune cell expressing adapter chimeric antigen receptor for sensing soluble antigens
CN115298209A (zh) * 2020-02-20 2022-11-04 森迪生物科学公司 抑制性嵌合受体构造体
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