KR20180075689A - 키메라 항원 수용체에 관한 방법 및 조성물 - Google Patents

키메라 항원 수용체에 관한 방법 및 조성물 Download PDF

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KR20180075689A
KR20180075689A KR1020187017328A KR20187017328A KR20180075689A KR 20180075689 A KR20180075689 A KR 20180075689A KR 1020187017328 A KR1020187017328 A KR 1020187017328A KR 20187017328 A KR20187017328 A KR 20187017328A KR 20180075689 A KR20180075689 A KR 20180075689A
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protein interaction
cell
polypeptide
interaction domain
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Korean (ko)
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윌슨 웡
장환 조
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트르스티스 오브 보스톤 유니버시티
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Priority to KR1020257028281A priority Critical patent/KR20250134209A/ko
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
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    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
    • A61K2239/29—Multispecific CARs
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2319/00—Fusion polypeptide
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    • C12N2510/00—Genetically modified cells

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020187017328A 2015-11-23 2016-11-22 키메라 항원 수용체에 관한 방법 및 조성물 Ceased KR20180075689A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257028281A KR20250134209A (ko) 2015-11-23 2016-11-22 키메라 항원 수용체에 관한 방법 및 조성물

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562258712P 2015-11-23 2015-11-23
US62/258,712 2015-11-23
PCT/US2016/063257 WO2017091546A1 (en) 2015-11-23 2016-11-22 Methods and compositions relating to chimeric antigen receptors

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KR1020257028281A Division KR20250134209A (ko) 2015-11-23 2016-11-22 키메라 항원 수용체에 관한 방법 및 조성물

Publications (1)

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KR20180075689A true KR20180075689A (ko) 2018-07-04

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KR1020187017328A Ceased KR20180075689A (ko) 2015-11-23 2016-11-22 키메라 항원 수용체에 관한 방법 및 조성물
KR1020257028281A Pending KR20250134209A (ko) 2015-11-23 2016-11-22 키메라 항원 수용체에 관한 방법 및 조성물

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KR1020257028281A Pending KR20250134209A (ko) 2015-11-23 2016-11-22 키메라 항원 수용체에 관한 방법 및 조성물

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US (2) US11530252B2 (https=)
EP (1) EP3380602A4 (https=)
JP (1) JP7621053B2 (https=)
KR (2) KR20180075689A (https=)
CN (1) CN108495927A (https=)
HK (1) HK1259190A1 (https=)
WO (1) WO2017091546A1 (https=)

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US11091546B2 (en) * 2015-04-15 2021-08-17 The Scripps Research Institute Optimized PNE-based chimeric receptor T cell switches and uses thereof
US11701387B2 (en) 2018-01-04 2023-07-18 Miltenyi Biotec B.V. & Co. KG Chimeric antigen receptor specific for BDCA2 antigen
WO2019152957A1 (en) * 2018-02-02 2019-08-08 Arizona Board Of Regents On Behalf Of Arizona State University Dna-chimeric antigen receptor t cells for immunotherapy
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EP3836944A4 (en) * 2018-08-16 2022-05-11 Memorial Sloan Kettering Cancer Center LEUCINE ZIPPER BASED COMPOSITIONS AND METHODS OF USE
EP4588483A3 (en) * 2018-10-03 2025-09-24 University of Pittsburgh- Of the Commonwealth System of Higher Education Covalent adaptor synnotch and chimeric antigen receptors (cars) for programmable antigen-targeting
EP3873540A4 (en) 2018-10-31 2022-07-27 Mayo Foundation for Medical Education and Research METHODS AND MATERIALS FOR THE TREATMENT OF CANCER
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ES3051182T3 (en) 2019-01-23 2025-12-26 Miltenyi Biotec Bv & Co Kg A combination of compositions for elimination and enhanced engraftment of hematopoietic stem cells in the bone marrow of a subject
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WO2021007580A1 (en) 2019-07-11 2021-01-14 Valkyr, Inc. System and methods relating to chimeric autoantibody receptors
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JP2023500799A (ja) 2019-10-18 2023-01-11 トラスティーズ オブ ボストン ユニバーシティ Ｃａｌ－ｔコンストラクトおよびその使用
CN115052887B (zh) 2019-12-11 2026-03-31 A2生物治疗公司 基于lilrb1的嵌合抗原受体
WO2021143826A1 (zh) * 2020-01-17 2021-07-22 信达生物制药(苏州)有限公司 重组抗程序性死亡受体1和抗分化抗原簇137双特异性抗体制剂及其用途
CN111234033B (zh) * 2020-01-21 2021-05-11 南京北恒生物科技有限公司 多链嵌合抗原受体及其用途
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CA3171906A1 (en) 2020-03-16 2021-09-23 University Of Southern California Novel antigen binding domains and synthetic antigen receptors incorporating the same
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