CN108478766A - A kind of drug and preparation method thereof for treating internal moisture and microcirculation silting - Google Patents
A kind of drug and preparation method thereof for treating internal moisture and microcirculation silting Download PDFInfo
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- CN108478766A CN108478766A CN201810495765.5A CN201810495765A CN108478766A CN 108478766 A CN108478766 A CN 108478766A CN 201810495765 A CN201810495765 A CN 201810495765A CN 108478766 A CN108478766 A CN 108478766A
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- leaf
- preparation
- folium artemisiae
- artemisiae argyi
- dried peppermint
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
The present invention relates to a kind of drugs and preparation method thereof for treating internal moisture and microcirculation silting.The preparation process of drug：Folium artemisiae argyi, dried peppermint leaf and mulberry leaf are mixed, mixture is obtained；The mixture is steamed with water smoking, zanthoxylum powder and ginger powder, then vacuum freeze drying is then added, obtains dried object, is shaped, then spontaneous fermentation 3 years or more at 10~35 DEG C；Wherein, the mass ratio of folium artemisiae argyi, dried peppermint leaf and mulberry leaf is 6~10:0.5~2:0.5~2, the dosage of the zanthoxylum powder be the folium artemisiae argyi, the dried peppermint leaf and the mulberry leaf gross mass 2~4%, the dosage of the ginger powder be the folium artemisiae argyi, dried peppermint leaf and mulberry leaf gross mass 1~3%.The present invention can be such that the active constituent in medicinal material releases, while preparation flow is simple, be not necessarily to complex operations condition or complex device, it is more easy to industrialization promotion, drug has higher curative effect to internal moisture and microcirculation silting, and cure rate is up to 90% or more, and treatment cycle is short.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly, to a kind of drug for treating internal moisture and microcirculation silting and
Preparation method.
Background technology
Microcirculation is the blood circulation in capillary between arteriole and venule, is the knot of circulatory system Zhong bases
Structure and functional unit.It includes the body fluid circulatory in arteriole, venule, capillary lymph duct and tissue tract.The each device of human body
Official, each histocyte are intended to provide oxygen, nutriment by microcirculation, transmit energy, and exchange of information excludes carbon dioxide and metabolism
Waste.Therefore, the normal operation of microcirculation is of crucial importance to health.
Microcirculation disorder is the change of blood physicochemical property, makes luminal stenosis, velocity of blood flow or is slowed down or thrombosis, is made
The even necrosis of local organization hypoxic-ischemic, causes a series of clinical symptoms, the unimpeded all kinds of diseases and ailments of microcirculation not to be given birth to, microcirculation disorder is hundred
The source of disease, main performance is silting.Sound microcirculation function be ensure internal important organ execute normal function it is primary before
It carries, medicine is proved：The aging of human body, the generation of tumour, hypertension, diabetes and many cardio-cerebrovascular diseases are mainly
Caused by microcirculation disorder, thus microcirculation normally whether, be human body whether health important symbol.Life style now, drink
Food, pressure, pollution etc. are all to cause the primary outer reason of microcirculation disorder.With advancing age, the cell and blood of human body
Liquid can gradual aging, function also degenerates therewith naturally, this is to cause microcirculation disorder internal cause.Obstacle, which occurs, for microcirculation to make
Many people are in sub-health state, other major diseases such as heart infarction or apoplexy can be caused when serious.
Internal moisture is often accompanied with microcirculation disorder.Chinese medicine thinks：Spleen energy transmitting and distributing the fluids.Spleen happiness it is dry and dislike it is wet,
If spleen sun rouses oneself, the strong fortune of spleen, the fortune wet function of water skiing is normal, and damp evil is then not easy to cause a disease.Conversely, after moisture causes ill very much again,
Patient often occur it is dizzy it is nose heave, four limbs are listless and aching, body is heavy and pain, joint joint stuffiness, depressed and oppressed sensation in the chest, abdominal fullness and distention, nausea desire
It spits, lose the appetite, the symptoms such as diarrhea, thick greasy fur.
Current traditional Chinese medicine is fresh few in relation to the report for treating internal moisture and microcirculation silting, therefore works out a kind of efficient
The Chinese medicine for curing internal moisture and microcirculation silting is extremely urgent.
In view of this, special propose the present invention.
Invention content
The first object of the present invention is to provide a kind of preparation method of drug that treating internal moisture and microcirculation silting,
The preparation method can be such that the active constituent in medicinal material releases, and become silted up by the internal moisture of appropriate fermentation generation treatment and microcirculation
Stifled a variety of effective components, while preparation flow is simple, is not necessarily to complex operations condition or complex device, is more easy to industrialization promotion.
The second object of the present invention is to provide a kind of drug for treating internal moisture and microcirculation silting, and the drug is to body
Interior moisture and microcirculation silting have higher curative effect, and cure rate is up to 90% or more, and treatment cycle is short.
In order to achieve the goal above, the present invention provides following technical schemes：
A kind of preparation method of drug that treating internal moisture and microcirculation silting, includes the following steps：
Folium artemisiae argyi, dried peppermint leaf and mulberry leaf are mixed, mixture is obtained；
The mixture is steamed with water smoking, zanthoxylum powder and ginger powder, then vacuum freeze drying are then added thereto, is done
Dry object；
The dried object is shaped, then spontaneous fermentation 3 years or more at 10~35 DEG C；
Wherein, the mass ratio of the folium artemisiae argyi, the dried peppermint leaf and the mulberry leaf is 6~10:0.5~2:0.5~2, it is described
The dosage of zanthoxylum powder be the folium artemisiae argyi, the dried peppermint leaf and the mulberry leaf gross mass 2~4%, the dosage of the ginger powder
It is the 1~3% of the gross mass of the folium artemisiae argyi, dried peppermint leaf and mulberry leaf.
The present invention selects folium artemisiae argyi, dried peppermint leaf, mulberry leaf, zanthoxylum powder and ginger powder, with the proportioning prescription of science, and by smoked
It steams, be freeze-dried, spontaneous fermentation (especially anaerobic fermentation), so that active constituent in medicinal material is completely retained, and fully discharge
Out, it is conducive to absorption of human body, some, which are also difficult to the ingredient absorbed fermentation, is decomposed into the active constituent that can be quickly absorbed by the body.
In summary technique, drug produced by the present invention have good curative effect, effective percentage to reach internal moisture and microcirculation silting
100%, cure rate reaches 90% or more.
Suitable for being applied with, application method is drug obtained by the present invention：Drug is broken into pieces with one's fingers and is impregnated with boiling water, then with the solution
Bubble foot is bathed, or cleans whole body, or cleans affected part.Internal moisture is treated using the above method, daily using 10~20 grams, 20
It can be cured in it.Microcirculation silting is treated using the above method, using can cure in 10~20 grams, 30 days daily.
Method made above can also be further improved, specific as follows to improve drug effect.
Preferably, the stifling condition is：70~100 DEG C, 0.5~1h.
It is stifling vapor to be made to be sufficiently submerged in medicinal material, as solvent, be added the leaching of effective component in medicinal material with
And mutually fusion, stifling temperature can be the arbitrary temp within the scope of 70~100 DEG C, can also be controlled and become with constant temperature
Change within the scope of little temperature, for example, 70 DEG C, 75 DEG C, 80 DEG C, 85 DEG C, 90 DEG C, 95 DEG C, 100 DEG C, 70~75 DEG C, 75~80 DEG C,
80~85 DEG C, 85~90 DEG C etc..
In addition, the unsuitable process of fumigation time, is excellent with 0.5~1h.
It is highly preferred that the stifling condition is：80~100 DEG C, 0.5~1h.
Preferably, the condition of the vacuum freeze drying is：- 60~-40 DEG C, vacuum degree -0.08MPa~-0.06MPa,
120~144 hours time.
Vacuum freeze drying can occur physically or chemically to go bad to avoid medicinal material or organized enzyme inactivates, and makes all drug effects
Ingredient utmostly retains, and preferably operating condition is as above.
Preferably, the temperature of the spontaneous fermentation is 20~35 DEG C.
The temperature of spontaneous fermentation can be the arbitrary value within the scope of 20~35 DEG C, with constant temperature or can be maintained at relatively narrow range
It is interior.
The mass ratio of the folium artemisiae argyi, the dried peppermint leaf and the mulberry leaf is 6~10:0.5~2:Arbitrary ratio in 0.5~2,
Such as 7~10:0.5~2:0.5~2,6.5~10:1~2:0.5~2,7.5~10:0.5~2:1.5~2,6~10:0.5~
1.5:0.5~2 etc..
Wherein it is preferred to which the mass ratio of the folium artemisiae argyi, the dried peppermint leaf and the mulberry leaf is 8~10:1~2:0.5~2；
It is highly preferred that the mass ratio of the folium artemisiae argyi, the dried peppermint leaf and the mulberry leaf is 8~10:1~2:0.5~1.
Preferably, the dosage of the zanthoxylum powder be the folium artemisiae argyi, the dried peppermint leaf and the mulberry leaf gross mass 3~
4%, such as 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4% etc..
Preferably, the dosage of the ginger powder be the folium artemisiae argyi, dried peppermint leaf and mulberry leaf gross mass 1~2%., such as
1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 4% etc..
Preferably, before the mixing, the folium artemisiae argyi, the dried peppermint leaf and the mulberry leaf are dried to biodiversity and is contained
Amount is 8%~12%,
On the one hand, be conducive to the mixing of three kinds of medicinal materials and zanthoxylum powder, ginger powder, on the other hand, the medicine after drying after drying
Material is more conducive to rub, biodiversity content more preferable 8%~10%.
Preferably, the addition zanthoxylum powder and ginger powder further include later and before the vacuum freeze drying：Rubbing is extremely
Uniformly.Zanthoxylum powder and ginger powder is set to be evenly affixed to interlobar part or surface, it is proposed that be twisted into strip.
Preferably, the method for the sizing is：It is pressed into pie.
The shape of sizing can also be changed as needed.
In addition, in order to promote the degree of anaerobic fermentation in spontaneous fermentation, it is proposed that ferment indoors.
Further include after fumigating and before vacuum freeze drying：Natural cooling.
Natural cooling can destroy the shape and active ingredient of medicinal material to avoid temperature decrease.
Preferably, the folium artemisiae argyi, the dried peppermint leaf and the mulberry leaf select fresh leaf.
To sum up, compared with prior art, invention achieves following technique effects：
(1) there is higher curative effect to internal moisture and microcirculation silting；
(2) the problems such as application method is simple, and there is no palatability, compliance, stomach first pass effects；
(3) without side-effects to human body；
(4) formula is simple, and medicinal material is common raw material, at low cost；
(5) preparation method can carry out at normal temperatures and pressures, and flow is simple, not be related to complex device, therefore easily
Industrialization promotion.
Specific implementation mode
Technical scheme of the present invention is clearly and completely described below in conjunction with specific implementation mode, but ability
Field technique personnel will be understood that following described embodiments are some of the embodiments of the present invention, instead of all the embodiments,
It is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.Based on the embodiments of the present invention, the common skill in this field
The every other embodiment that art personnel are obtained without making creative work belongs to the model that the present invention protects
It encloses.The person that is not specified actual conditions in embodiment, carries out according to conventional conditions or manufacturer's recommended conditions.Agents useful for same or instrument
Production firm person is not specified, is the conventional products that can be obtained by commercially available purchase.
Embodiment 1
A kind of preparation method of drug that treating internal moisture and microcirculation silting, includes the following steps：
(1) feeding：Folium artemisiae argyi 800g, dried peppermint leaf 100g, mulberry leaf 100g.
(2) it pre-processes：Folium artemisiae argyi, dried peppermint leaf, mulberry leaf are cleaned, re-dry to biodiversity content is 10wt%.Leaf at this time
At spiritless state, it is twisted into curling item.
(3) it fumigates：Leaf is steamed with water smoking, temperature controls at 70~80 DEG C, fumigates 0.5h, make in water fully penetrated to blade.
(4) it mixes：Zanthoxylum powder 30g and ginger powder 20g is added into the leaf after above-mentioned fumigate.
(5) it rubs：Material is obtained to (4) to rub repeatedly, until zanthoxylum powder and ginger powder are adsorbed in or are involved in flap.
(6) vacuum freeze drying：The condition of vacuum freeze drying is：- 60~-50 DEG C, vacuum degree -0.08MPa~-
0.06MPa, 120 hours time；Then take out medicinal material, natural cooling.
(7) it shapes：It is pressed into pie with tablet press machine.
(8) spontaneous fermentation：Under room temperature disposed within, control temperature is fermented 3 years at 10~25 DEG C.
The application method of the drug is：10g~20g is taken, is impregnated with boiling water or warm water, impregnates trouble while hot with the soup bubbled out
Place.
Embodiment 2
A kind of preparation method of drug that treating internal moisture and microcirculation silting, includes the following steps：
(1) feeding：Folium artemisiae argyi 800g, dried peppermint leaf 100g, mulberry leaf 100g.
(2) it pre-processes：Folium artemisiae argyi, dried peppermint leaf, mulberry leaf are cleaned, re-dry to biodiversity content is 10wt%.Leaf at this time
At spiritless state, it is twisted into curling item.
(3) it fumigates：The material that (2) obtain is steamed with water smoking, temperature controls at 70~80 DEG C, fumigates 0.5h, water is made fully to ooze
Thoroughly in blade.
(4) it mixes：Zanthoxylum powder 30g and ginger powder 20g is added into the leaf after above-mentioned fumigate.
(5) it rubs：Material is obtained to (4) to rub repeatedly, until zanthoxylum powder and ginger powder are adsorbed in or are involved in flap.
(6) vacuum freeze drying：The condition of vacuum freeze drying is：- 50~-40 DEG C, vacuum degree -0.08MPa~-
0.06MPa, 144 hours time；Then take out medicinal material, natural cooling.
(7) it shapes：It is pressed into pie with tablet press machine.
(8) spontaneous fermentation：Under room temperature disposed within, control temperature is fermented 3 years at 10~25 DEG C.
The application method of the drug is：10g~20g is taken, is impregnated with boiling water or warm water, impregnates trouble while hot with the soup bubbled out
Place.
Embodiment 3
A kind of preparation method of drug that treating internal moisture and microcirculation silting, includes the following steps：
(1) feeding：Folium artemisiae argyi 600g, dried peppermint leaf 200g, mulberry leaf 200g.
(2) it pre-processes：Folium artemisiae argyi, dried peppermint leaf, mulberry leaf are cleaned, re-dry to biodiversity content is 10wt%.Leaf at this time
At spiritless state, it is twisted into curling item.
(3) it fumigates：The material that (2) obtain is steamed with water smoking, temperature controls at 70~80 DEG C, fumigates 0.5h, water is made fully to ooze
Thoroughly in blade.
(4) it mixes：Zanthoxylum powder 20g and ginger powder 30g is added into above-mentioned leaf.
(5) it rubs：Material is obtained to (4) to rub repeatedly, until zanthoxylum powder and ginger powder are adsorbed in or are involved in flap.
(6) vacuum freeze drying：The condition of vacuum freeze drying is：- 60~-50 DEG C, vacuum degree -0.08MPa~-
0.06MPa, 120 hours time；Then take out medicinal material, natural cooling.
(7) it shapes：It is pressed into pie with tablet press machine.
(8) spontaneous fermentation：Under room temperature disposed within, control temperature is fermented 3 years at 10~25 DEG C.
The application method of the drug is：10g~20g is taken, is impregnated with boiling water or warm water, impregnates trouble while hot with the soup bubbled out
Place.
Embodiment 4
A kind of preparation method of drug that treating internal moisture and microcirculation silting, includes the following steps：
(1) feeding：Folium artemisiae argyi 800g, dried peppermint leaf 50g, mulberry leaf 150g.
(2) it pre-processes：Folium artemisiae argyi, dried peppermint leaf, mulberry leaf are cleaned, re-dry to biodiversity content is 10wt%.Leaf at this time
At spiritless state, it is twisted into curling item.
(3) it fumigates：The material that (2) obtain is steamed with water smoking, temperature controls at 70~80 DEG C, fumigates 0.5h, water is made fully to ooze
Thoroughly in blade.
(4) it mixes：Zanthoxylum powder 40g and ginger powder 10g is added into the leaf after above-mentioned drying.
(5) it rubs：Material is obtained to (4) to rub repeatedly, until zanthoxylum powder and ginger powder are adsorbed in or are involved in flap.
(6) vacuum freeze drying：The condition of vacuum freeze drying is：- 60~-50 DEG C, vacuum degree -0.08MPa~-
0.06MPa, 120 hours time；Then take out medicinal material, natural cooling.
(7) it shapes：It is pressed into pie with tablet press machine.
(8) spontaneous fermentation：Under room temperature disposed within, control temperature is fermented 3 years at 10~25 DEG C.
The application method of the drug is：10g~20g is taken, is impregnated with boiling water or warm water, impregnates trouble while hot with the soup bubbled out
Place.
Embodiment 5
A kind of preparation method of drug that treating internal moisture and microcirculation silting, includes the following steps：
(1) feeding：Folium artemisiae argyi 1000g, dried peppermint leaf 50g, mulberry leaf 50g.
(2) it pre-processes：Folium artemisiae argyi, dried peppermint leaf, mulberry leaf are cleaned, re-dry to biodiversity content is 10wt%.Leaf at this time
At spiritless state, it is twisted into curling item.
(3) it fumigates：The material that (2) obtain is steamed with water smoking, temperature controls at 70~80 DEG C, fumigates 0.5h, water is made fully to ooze
Thoroughly in blade.
(4) it mixes：Zanthoxylum powder 30g and ginger powder 20g is added into the leaf after above-mentioned drying.
(5) it rubs：Material is obtained to (4) to rub repeatedly, until zanthoxylum powder and ginger powder are adsorbed in or are involved in flap.
(6) vacuum freeze drying：The condition of vacuum freeze drying is：- 60~-50 DEG C, vacuum degree -0.08MPa~-
0.06MPa, 120 hours time；Then take out medicinal material, natural cooling.
(7) it shapes：It is pressed into pie with tablet press machine.
(8) spontaneous fermentation：Under room temperature disposed within, control temperature is fermented 3 years at 10~25 DEG C.
The application method of the drug is：10g~20g is taken, is impregnated with boiling water or warm water, impregnates trouble while hot with the soup bubbled out
Place.
Embodiment 6
A kind of preparation method of drug that treating internal moisture and microcirculation silting, includes the following steps：
(1) feeding：Folium artemisiae argyi 800g, dried peppermint leaf 100g, mulberry leaf 100g.
(2) it pre-processes：Folium artemisiae argyi, dried peppermint leaf, mulberry leaf are cleaned, re-dry to biodiversity content is 10wt%.Leaf at this time
At spiritless state, it is twisted into curling item.
(3) it fumigates：The material that (2) obtain is steamed with water smoking, temperature controls at 70~80 DEG C, fumigates 0.5h, water is made fully to ooze
Thoroughly in blade.
(4) it mixes：Zanthoxylum powder 40g and ginger powder 30g is added into the leaf after above-mentioned drying.
(5) it rubs：Material is obtained to (4) to rub repeatedly, until zanthoxylum powder and ginger powder are adsorbed in or are involved in flap.
(6) vacuum freeze drying：The condition of vacuum freeze drying is：- 60~-50 DEG C, vacuum degree -0.08MPa~-
0.06MPa, 120 hours time；Then take out medicinal material, natural cooling.
(7) it shapes：It is pressed into pie with tablet press machine.
(8) spontaneous fermentation：Under room temperature disposed within, control temperature is fermented 3 years at 10~25 DEG C.
The application method of the drug is：10g~20g is taken, is impregnated with boiling water or warm water, impregnates trouble while hot with the soup bubbled out
Place.
Embodiment 7
A kind of preparation method of drug that treating internal moisture and microcirculation silting, includes the following steps：
(1) feeding：Folium artemisiae argyi 800g, dried peppermint leaf 100g, mulberry leaf 100g.
(2) it pre-processes：Folium artemisiae argyi, dried peppermint leaf, mulberry leaf are cleaned, re-dry to biodiversity content is 10wt%.Leaf at this time
At spiritless state, it is twisted into curling item.
(3) it fumigates：The material that (2) obtain is steamed with water smoking, temperature controls at 90~100 DEG C, fumigates 1h, make water fully penetrated
Into blade.
(4) it mixes：Zanthoxylum powder 30g and ginger powder 20g is added into the leaf after above-mentioned drying.
(5) it rubs：Material is obtained to (4) to rub repeatedly, until zanthoxylum powder and ginger powder are adsorbed in or are involved in flap.
(6) vacuum freeze drying：The condition of vacuum freeze drying is：- 60~-50 DEG C, vacuum degree -0.08MPa~-
0.06MPa, 120 hours time；Then take out medicinal material, natural cooling.
(7) it shapes：It is pressed into pie with tablet press machine.
(8) spontaneous fermentation：Under room temperature disposed within, control temperature is fermented 3 years at 10~25 DEG C.
The application method of the drug is：10g~20g is taken, is impregnated with boiling water or warm water, impregnates trouble while hot with the soup bubbled out
Place.
The clinical application situation of 1 gained drug of embodiment is as shown in table 1 below.
The effect of 1 drug of table is to internal moisture and microcirculation silting
Note：Internal moisture 102, microcirculation silting 112, the application method of drug are：10g~15g is taken, is soaked with boiling water
Bubble, impregnates affected part while hot with the soup bubbled out.To being cured completely within internal moisture 20, to being controlled completely within microcirculation silting 30
More.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to
So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into
Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of preparation method of drug that treating internal moisture and microcirculation silting, which is characterized in that include the following steps：
Folium artemisiae argyi, dried peppermint leaf and mulberry leaf are mixed, mixture is obtained；
The mixture is steamed with water smoking, zanthoxylum powder and ginger powder, then vacuum freeze drying are then added thereto, obtains drying
Object；
The dried object is shaped, then spontaneous fermentation 3 years or more at 10~35 DEG C；
Wherein, the mass ratio of the folium artemisiae argyi, the dried peppermint leaf and the mulberry leaf is 6~10:0.5~2:0.5~2, the Chinese prickly ash
The dosage of powder be the folium artemisiae argyi, the dried peppermint leaf and the mulberry leaf gross mass 2~4%, the dosage of the ginger powder is institute
State folium artemisiae argyi, the dried peppermint leaf and the mulberry leaf gross mass 1~3%.
2. preparation method according to claim 1, which is characterized in that the stifling condition is：70~100 DEG C, 0.5~
1h；
Preferably, the stifling condition is：80~100 DEG C, 0.5~1h.
3. preparation method according to claim 1, which is characterized in that the condition of the vacuum freeze drying is：- 60~-
40 DEG C, vacuum degree -0.08MPa~-0.06MPa, 120~144 hours time.
4. preparation method according to claim 1, which is characterized in that the temperature of the spontaneous fermentation is 20~35 DEG C.
5. according to claim 1-4 any one of them preparation methods, which is characterized in that the folium artemisiae argyi, the dried peppermint leaf and institute
The mass ratio for stating mulberry leaf is 8~10:1~2:0.5~2；
Preferably, the mass ratio of the folium artemisiae argyi, the dried peppermint leaf and the mulberry leaf is 8~10:1~2:0.5~1.
6. according to claim 1-4 any one of them preparation methods, which is characterized in that the dosage of the zanthoxylum powder is the Chinese mugwort
The 3~4% of the gross mass of leaf, the dried peppermint leaf and the mulberry leaf.
7. according to claim 1-4 any one of them preparation methods, which is characterized in that the dosage of the ginger powder is the Chinese mugwort
The 1~2% of the gross mass of leaf, the dried peppermint leaf and the mulberry leaf.
8. preparation method according to claim 1, which is characterized in that before the mixing, by the folium artemisiae argyi, described thin
It is 8%~12%, preferably 8%~10% that lotus leaf and the mulberry leaf, which are dried to biodiversity content,.
9. preparation method according to claim 1, which is characterized in that after the addition zanthoxylum powder and ginger powder and described
Further include before vacuum freeze drying：It rubs to uniform；
Preferably, the method for the sizing is：It is pressed into pie.
10. a kind of drug for treating internal moisture and microcirculation silting, which is characterized in that using any one of claim 1-9 institutes
The preparation method stated is made.
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