CN108478652A - A kind of Chinese medicine preparation and preparation method thereof preventing transmissible gastroenteritis of swine - Google Patents

Abstract

The present invention relates to a kind of Chinese medicine preparations and preparation method thereof preventing transmissible gastroenteritis of swine, it is made of following raw material：Lactobacillus acidophilus 30 ~ 60, Cortex Phellodendri 20 ~ 50, pueraria lobata 40 ~ 60, Radix Astragali 10 ~ 30, yellow mustard 5 ~ 20 and kuh-seng 10 ~ 25；Specific preparation method is first to mix each raw material powder other than lactobacillus acidophilus to decoct, and is condensed into dry powder, the product for being then uniformly mixed dry powder with lactobacillus acidophilus；The drug with transmissible gastroenteritis of swine with good therapeutic effect, is had no toxic side effect, is had no drug resistance, it is cheap the advantages that.

Description

A kind of Chinese medicine preparation and preparation method thereof preventing transmissible gastroenteritis of swine

Technical field

The invention belongs to veterinary drug technical fields, and in particular to a kind of Chinese medicine preparation and its system preventing transmissible gastroenteritis of swine Preparation Method.

Background technology

Transmissible gastroenteritis of swine is a kind of high degree in contact alimentary infection for causing pig by transmissible gastro-enteritis virus Disease.Characterized by vomiting, watery diarrhea and dehydration.OIE is classified as B class animal epidemics.The reservoir host of TGE viruses is at least Four kinds, the first is pig farm of the virus diffusion in inferior clinical symptom, such as fattens pig farm or constantly has the pig farm of newborn piglet, TGE Virus is sustainable to be present in these pig farms, once arrive the adaptation season of morbidity, you can cause the outburst of this disease.It is for second Dog, cat, fox, cowbird, fly etc. are with poison, toxin expelling, the propagation of machinery this disease；The third is that the malicious pig of band or morbid pig pass through nose Endocrine, excrement, milk toxin expelling；4th kind is the spoil for having infected TGE viruses.It is proved that blood and after butchering Waste can by TGE viruses be passed to swinery.TGE virus titers are up in some tissues such as kidney of viral toxaemia phase 10TCID50/ml.The meat of these slaughter pigs also can transmitted virus.

According to the neurological susceptibility of all ages and classes pig, TGE can be in three kinds of popular forms.One is in popularity, for susceptible pig Group can usually rapidly result in the pig morbidity at various ages after TGE poisoning intrusions, and especially in winter, most of pig performances are not With the clinical symptom of degree；Secondly being in endemicity, it is confined to the pig farm for often having piglet to be born or is continuously increased susceptible pig As fattening pig pig farm in, although piglet can obtain passive immunity after immune or from sow milk, by the time and exempt from The limitation of epidemic disease ability, when virus infectivity is more than the immunity of pig, pig will be infected.So TGE viruses can deposit for a long time It is in these swinerys；Thirdly being in periodic epidemic, often betides TGE viruses and invade the pig farm for having immune sow again, due to Previous winter infected pigs have been butchered in summer or autumn, newly into feeder pig and deliver pig for sale and become as susceptible pig.

It will appear vomiting within 12~24 hours after Infection in Piglets within general 2 week old, serious water sample or paste then occur Shape diarrhea, excrement are in yellow, often accompany indigested ziega, stench, and weight declines rapidly, and piglet is obviously dehydrated, and morbidity 2~ Death in 7 days, the death rate is up to 100%；In the piglet of 2~3 week old, the death rate is 0~10%.It falls ill within 2~4 days after pig of weaning infects, Watery diarrhea is showed, is in spurting, excrement gray or brown, individual pig vomitings, diarrhea stops after 5~8 days, few dead, but Weight loss often shows depauperation, becomes cad pig.Some sows and illness piglet close contact repeated infection, symptom is heavier, Body temperature increases, and lactation stops, vomiting, loss of appetite and diarrhea, and also some milking sows do not show clinical symptom.

Since transmissible gastroenteritis of swine harm is serious, need effectively to prevent it.

Invention content

In order to solve the above technical problem, the present invention provides it is a kind of prevent transmissible gastroenteritis of swine Chinese medicine preparation and its Preparation method, the drug is with, with good therapeutic effect, having no toxic side effect, have no drug resistance to transmissible gastroenteritis of swine, valence The advantages that lattice are cheap.

To achieve the above object, the technical solution that the present invention takes is：

The present invention relates to a kind of Chinese medicine preparations preventing transmissible gastroenteritis of swine, it is made of following raw material：Acidophilus Lactobacillus 30 ~ 60, Cortex Phellodendri 20 ~ 50, pueraria lobata 40 ~ 60, Radix Astragali 10 ~ 30, yellow mustard 5 ~ 20 and kuh-seng 10 ~ 25.

According to the Chinese medicine preparation of above-mentioned prevention transmissible gastroenteritis of swine, it is made of following raw material：Acidophilus Lactobacillus 30 ~ 50, Cortex Phellodendri 35 ~ 50, pueraria lobata 40 ~ 50, Radix Astragali 20 ~ 30, yellow mustard 5 ~ 10 and kuh-seng 10 ~ 15.

According to the Chinese medicine preparation of above-mentioned prevention transmissible gastroenteritis of swine, it is made of following raw material：Acidophilus Lactobacillus 50 ~ 60, Cortex Phellodendri 20 ~ 35, pueraria lobata 50 ~ 60, Radix Astragali 10 ~ 20, yellow mustard 10 ~ 20 and kuh-seng 15 ~ 25.

According to the Chinese medicine preparation of above-mentioned prevention transmissible gastroenteritis of swine, it is made of following raw material：Acidophilus Lactobacillus 50, Cortex Phellodendri 35, pueraria lobata 60, Radix Astragali 25, yellow mustard 15 and kuh-seng 20.

According to the preparation method of the Chinese medicine preparation of above-mentioned prevention transmissible gastroenteritis of swine, it includes the following steps：

（1）Weigh each raw material Cortex Phellodendri, pueraria lobata, Radix Astragali, yellow mustard and kuh-seng by the parts by weight of constitutive material, then mix raw material is mixed Object is closed, is decocted 2 times with water, collecting decoction, is concentrated under reduced pressure into the clear cream that density is 1.14 ~ 1.28g/ml, being subject to clear cream weight is The ethanol water mixing of 1 ~ 2 times of amount of benchmark, stands 24 ~ 30 hours, takes supernatant, ethyl alcohol is recovered under reduced pressure, be condensed into density For the thick paste of 1.69 ~ 1.82g/ml, it is concentrated under reduced pressure into dry powder at a temperature of 90 ~ 95 DEG C；

（2）Lactobacillus acidophilus is weighed by weight ratio, with step（1）In obtained dry powder be put into blending tank and be sufficiently mixed It is even to get to prevent transmissible gastroenteritis of swine Chinese medicine preparation.

The drug effect of each raw material in the present invention：

Lactobacillus acidophilus：There is antagonism to pathogenic microorganisms.Lactobacillus acidophilus can secrete antibiotin substance (acidophilus breast Rhzomorph (acidolin), bacillus acidophilus plain (acidophilin), lactein (1aetocidon)), pathogenic entero becteria is generated Antagonism.

Cortex Phellodendri：Bitter, it is cold in nature.Return kidney, bladder, large intestine channel.Heat-clearing and damp-drying drug；Purging intense heat and detonicating.Main damp-heat dysentery, diarrhea, Huang Subcutaneous ulcer；Under nocturnal emission, stranguria with turbid discharge, band；Hectic fever due to yin labor heat；And aphthae；Red eye, swell pain；Skin sore；Skin eczema.

Pueraria lobata：It is sweet in flavor, pungent, it is cool in nature.It brings down a fever with expelling pathogenic factors from muscles and skin, promoting eruption promotes the production of body fluid to quench thirst, the work(of Shengyang Zhixie.It is usually used in exterior syndrome Fever, stiff nape and back, measles without adequate eruption, pyreticosis is thirsty, and the deficiency of Yin is quenched one's thirst, and heat is purged heat dysentery, splenasthenic diarrhea.

Radix Astragali：It is sweet in flavor, slightly warm in nature.Return lung, spleen, liver and kidney channel.Invigorating qi for strengthening superficies, pus draining and toxin expelling, diuresis, myogenic.For the deficiency of vital energy The long disunion of weak, rush down prolapse of the anus for a long time, spontaneous perspiration, oedema, sub-official prolapses, chronic rephrilis protinuria, diabetes, the open sore part.

Yellow mustard：Its pharmacological action is summarized as follows：1. 2. refrigeration function of antibacterial action, 3. anti-inflammatory effect, 4. calmness, anticonvulsion work With 5. spasmolysis, 6. cholagogic, hepatoprotective effect.

Kuh-seng：Bitter, it is cold in nature.Enter the heart, lung, kidney, large intestine channel.It cures mainly：Heat-clearing and damp-drying drug, desinsection, diuresis.For hot dysentery, just Blood, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy；Control trichomonas vaginitis etc. outside.

Compared with prior art, beneficial effects of the present invention：

1, it is monarch drug in a prescription that the present invention, which selects Cortex Phellodendri, pueraria lobata, Radix Astragali, and dispersing stagnated hepatoqi, inducing diuresis for removing edema help digestion and stomach, and matrix is helped to eliminate The malaise symptoms such as the watery diarrhea, the vomiting that are brought because stomach Qi rising, and lactobacillus acidophilus is added with auxiliary adjustment gastrointestinal tract ring Border；Using yellow mustard as ministerial drug, promoting blood circulation and cooling blood, relieving restlessness analgesic, dispelling wind and eliminating dampness, sharp gas promoting menstruation assist monarch drug in a prescription, body blood are promoted to follow Ring helps system promoting blood circulation and stopping pain, while eliminating the cold of internal body, and has the effect of clearing away the heart fire and tranquillizing；Think kuh-seng adjutant, it is auxiliary During principal drug assistance and ministerial drug promoting qi circulation and relieving pain, lower gas are wide, Li Shui stimulates the menstrual flow, open and strongly fragrant be amusing, be clearing heat and detoxicating.The present invention selects above-mentioned all medicines, It cooperates, to adjust based on stomach qi-regulating, supplemented by promoting blood circulation and stopping pain, the above-mentioned all survival doses of rational allocation, pleasant and stomach, promoting blood circulation and stopping pain, Strongly fragrant tranquilizing the mind is opened, preferable prevention transmissible gastroenteritis of swine effect is reached.

2, drug matching science of the present invention, collocation are reasonable.Both table, i.e. dissipate stasis of blood hemostasis can be acted on, may also act on In, i.e., it is clearing heat and detoxicating.Meanwhile it being equipped with qi-regulating drug and Qi-tonifying drug, promote the rehabilitation of animal body.

3, the present invention is constituted simple, and raw material is easier to obtain, of low cost, can bring good economic benefit.

Specific implementation mode

With reference to embodiment, the invention will be further described, and the design parameter in example is merely to illustrate the present invention Rather than range is limited, those skilled in that art can be with suitably modified parameter of the present invention；

Embodiment 1：

A kind of Chinese medicine preparation preventing transmissible gastroenteritis of swine, it is made of following raw material：Lactobacillus acidophilus 50, Huang Cypress 35, pueraria lobata 60, Radix Astragali 25, yellow mustard 15 and kuh-seng 20.

The preparation method of the Chinese medicine preparation of the prevention transmissible gastroenteritis of swine, it includes the following steps：

（1）Weigh lactobacillus acidophilus, Cortex Phellodendri, Radix Glycyrrhizae, the membrane of a chicken's gizzard, pueraria lobata, Radix Astragali, yellow mustard and kuh-seng respectively by weight ratio, point It Jia Ru not be crushed in micronizer machine, and all lead to sieve with 100 mesh sieve respectively；

（2）Talcum powder is weighed respectively by weight ratio, with step（1）Lactobacillus acidophilus, Cortex Phellodendri, Radix Glycyrrhizae, chicken after middle sieving Interior gold, pueraria lobata, Radix Astragali, yellow mustard, kuh-seng, which are put into togerther in blending tank, to be sufficiently mixed uniformly to get to preventing transmissible gastroenteritis of swine Chinese medicine preparation.

Embodiment 2：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 30, Cortex Phellodendri 50, pueraria lobata 40, Radix Astragali 30, yellow mustard 5 and kuh-seng 25.

Embodiment 3：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 50, Cortex Phellodendri 50, pueraria lobata 45, Radix Astragali 20, yellow mustard 15 and kuh-seng 20.

Embodiment 4：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 35, Cortex Phellodendri 45, pueraria lobata 46, Radix Astragali 28, yellow mustard 6 and kuh-seng 23.

Embodiment 5：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 38, Cortex Phellodendri 47, pueraria lobata 42, Radix Astragali 26, yellow mustard 8 and kuh-seng 20.

Embodiment 6：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 40, Cortex Phellodendri 46, pueraria lobata 48, Radix Astragali 24, yellow mustard 9 and kuh-seng 23.

Embodiment 7：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 43, Cortex Phellodendri 40, pueraria lobata 49, Radix Astragali 22, yellow mustard 10 and kuh-seng 20.

Embodiment 8：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 50, Cortex Phellodendri 35, pueraria lobata 51, Radix Astragali 20, yellow mustard 12 and kuh-seng 18.

Embodiment 9：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 52, Cortex Phellodendri 33, pueraria lobata 52, Radix Astragali 18, yellow mustard 17 and kuh-seng 16.

Embodiment 10：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 53, Cortex Phellodendri 30, pueraria lobata 54, Radix Astragali 16, yellow mustard 18 and kuh-seng 14.

Embodiment 11：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 55, Cortex Phellodendri 28, pueraria lobata 56, Radix Astragali 15, yellow mustard 19 and kuh-seng 13.

Embodiment 12：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 56, Cortex Phellodendri 25, pueraria lobata 58, Radix Astragali 14, yellow mustard 20 and kuh-seng 12.

Embodiment 13：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 58, Cortex Phellodendri 24, pueraria lobata 59, Radix Astragali 13, yellow mustard 6 and kuh-seng 13.

Embodiment 14：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 36, Cortex Phellodendri 35, pueraria lobata 42, Radix Astragali 12, yellow mustard 13 and kuh-seng 15.

Embodiment 15：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 46, Cortex Phellodendri 40, pueraria lobata 40, Radix Astragali 14, yellow mustard 12 and kuh-seng 24.

Embodiment 16：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 49, Cortex Phellodendri 39, pueraria lobata 43, Radix Astragali 12, yellow mustard 18 and kuh-seng 21.

Embodiment 17：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 53, Cortex Phellodendri 24, pueraria lobata 45, Radix Astragali 13, yellow mustard 9 and kuh-seng 23.

Embodiment 18：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 56, Cortex Phellodendri 22, pueraria lobata 59, Radix Astragali 16, yellow mustard 13 and kuh-seng 22.

Embodiment 19：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 48, Cortex Phellodendri 38, pueraria lobata 43, Radix Astragali 18, yellow mustard 12 and kuh-seng 21.

Embodiment 20：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 50, Cortex Phellodendri 27, pueraria lobata 45, Radix Astragali 22, yellow mustard 6 and kuh-seng 24.

Embodiment 21：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 38, Cortex Phellodendri 42, pueraria lobata 52, Radix Astragali 28, yellow mustard 8 and kuh-seng 25.

Embodiment 22：

The present embodiment place same as Example 1 no longer repeats, the difference is that it is made of following raw material：It is thermophilic Lactobacillus lactis 60, Cortex Phellodendri 20, pueraria lobata 60, Radix Astragali 10, yellow mustard 20 and kuh-seng 10.

Preventive trial：

On the pig farm that epidemic situation occurs, 100 non-morbid pigs of health are randomly divided into 2 groups, every group 50, the 1st group is chemoprophylaxis Group；2nd group is control group；Drug 16g prepared by the embodiment of the present invention 1 is fed in the daily feed addition of 1st group of every pig（Piggy subtracts Half）, even feed 7 days；2nd group is not added；Two groups of other measures of pig all normally sterilize immune programme by pig farm.

The result shows that：The incidence of chemoprophylaxis group transmissible gastroenteritis of swine is 3.8%, and control group incidence is 72.0%, and the spirit of medicine group morbid pig, appetite are all better than control group, illness symptom is also light compared with control group.Prevention group is being fallen ill After give treatment after, cure rate 78.0%；And control group is 43.0%.

Above with respect to the specific descriptions of the present invention, it is merely to illustrate the present invention and is not limited to the embodiment of the present invention and is retouched The technical solution stated, it will be understood by those of ordinary skill in the art that, still can to row of the present invention change or equivalent replacement, with Reach identical technique effect；Needs are used as long as meeting, all within protection scope of the present invention.

Claims (5)

1. a kind of Chinese medicine preparation preventing transmissible gastroenteritis of swine, it is characterised in that it is made of following raw material：It is thermophilic Lactobacillus lactis 30 ~ 60, Cortex Phellodendri 20 ~ 50, pueraria lobata 40 ~ 60, Radix Astragali 10 ~ 30, yellow mustard 5 ~ 20 and kuh-seng 10 ~ 25.

2. the Chinese medicine preparation according to claim 1 for preventing transmissible gastroenteritis of swine, it is characterised in that it is by weighing as follows Amount part raw material is made：Lactobacillus acidophilus 30 ~ 50, Cortex Phellodendri 35 ~ 50, pueraria lobata 40 ~ 50, Radix Astragali 20 ~ 30, yellow mustard 5 ~ 10 and kuh-seng 10 ~ 15。

3. the Chinese medicine preparation according to claim 1 for preventing transmissible gastroenteritis of swine, it is characterised in that it is by weighing as follows Amount part raw material is made：Lactobacillus acidophilus 50 ~ 60, Cortex Phellodendri 20 ~ 35, pueraria lobata 50 ~ 60, Radix Astragali 10 ~ 20, yellow mustard 10 ~ 20 and kuh-seng 15 ~ 25。

4. the Chinese medicine preparation according to claim 1 for preventing transmissible gastroenteritis of swine, it is characterised in that it is by weighing as follows Amount part raw material is made：Lactobacillus acidophilus 50, Cortex Phellodendri 35, pueraria lobata 60, Radix Astragali 25, yellow mustard 15 and kuh-seng 20.

5. the preparation method of the Chinese medicine preparation according to claim 1 for preventing transmissible gastroenteritis of swine, it is characterised in that it Include the following steps：

（1）Weigh each raw material Cortex Phellodendri, pueraria lobata, Radix Astragali, yellow mustard and kuh-seng by the parts by weight of constitutive material, then mix raw material is mixed Object is closed, is decocted 2 times with water, collecting decoction, is concentrated under reduced pressure into the clear cream that density is 1.14 ~ 1.28g/ml, being subject to clear cream weight is The ethanol water mixing of 1 ~ 2 times of amount of benchmark, stands 24 ~ 30 hours, takes supernatant, ethyl alcohol is recovered under reduced pressure, be condensed into density For the thick paste of 1.69 ~ 1.82g/ml, it is concentrated under reduced pressure into dry powder at a temperature of 90 ~ 95 DEG C；

（2）Lactobacillus acidophilus is weighed by weight ratio, with step（1）In obtained dry powder be put into blending tank and be sufficiently mixed It is even to get to prevent transmissible gastroenteritis of swine Chinese medicine preparation.