CN108478616A

CN108478616A - Compound ketoprofen medicinal composition, pharmaceutical preparation and its application

Info

Publication number: CN108478616A
Application number: CN201810714315.0A
Authority: CN
Inventors: 寇贺红; 周淑贞; 焦伟丽; 元晓琪; 张庆
Original assignee: Foshan Nanhai Eastern Along Pharmaceutical Co Ltd
Current assignee: Foshan Nanhai Eastern Along Pharmaceutical Co Ltd
Priority date: 2018-06-29
Filing date: 2018-06-29
Publication date: 2018-09-04

Abstract

The present invention provides a kind of compound ketoprofen medicinal composition, pharmaceutical preparation and its applications, are related to technical field of medicine.Compound ketoprofen medicinal composition, including the following raw material component：Ketoprofen and Chinese medical extract, the Chinese medical extract include dandelion extract.Compound ketoprofen medicinal composition provided by the invention is using Ketoprofen and dandelion extract as primary raw material, mutual coordinated between each component has significant effect in treatment animal symptoms such as inflammation, fever and pain caused by the various diseases such as pneumonia, enteritis, mammitis and hysteritis.

Description

Compound ketoprofen medicinal composition, pharmaceutical preparation and its application

Technical field

The present invention relates to technical field of medicine, more particularly, to a kind of compound ketoprofen medicinal composition, drug system Agent and its application.

Background technology

With economic rapid development, animal-breeding intensive degree is higher and higher, and Animal diseases are also more and more, more next It is more complicated.Especially infectious diseases, such as pneumonia, enteritis, mammitis and the various diseases of hysteritis, finally body in animals It is now the symptoms such as inflammation, fever and pain.Other than using antibiotic to kill pathogen, it is also necessary to anti-inflammatory drug be coordinated to control It treats.But the symptoms such as inflammation, fever and pain are ineffective with current anti-inflammatory drug treatment animal.

In view of this, special propose the present invention.

Invention content

The first object of the present invention is to provide a kind of compound ketoprofen medicinal composition, be existed in the prior art with alleviating Treatment animal caused by the various diseases such as pneumonia, enteritis, mammitis and hysteritis the symptoms such as inflammation, fever and pain imitate The technical problems such as fruit is bad.

A kind of compound ketoprofen medicinal composition provided by the invention, including the following raw material component：Ketoprofen and Chinese medicine carry It includes dandelion extract to take object, the Chinese medical extract.

Further, the mass ratio of the Ketoprofen and Chinese medical extract is (1-30)：(0.1-30)；

Preferably, the mass ratio of the Ketoprofen and Chinese medical extract is (5-30)：(5-30)；

It is further preferred that the mass ratio of the Ketoprofen and Chinese medical extract is (10-20)：(10-20).

Further, the Chinese medical extract further includes that Honegsukle flower P.E, tripterygium glycosides extract, goldenrod carry Take at least one of object, Herba Patriniae extract, Herba Violae extract and Rabdosia rubescens extract；

Preferably, the dandelion extract, optional Honegsukle flower P.E, optional tripterygium glycosides extract, appoint Select Herba Solidaginis extract, optional Herba Patriniae extract, optional Herba Violae extract and optional Rabdosia rubescens extract Mass ratio be (1-10)：(1-10)：(1-10)：(1-10)：(1-10)：(1-10)：(1-10), further preferably (2-8)： (2-8)：(2-8)：(2-8)：(2-8)：(2-8)：(2-8).

Further, the Honegsukle flower P.E is Flos Lonicerae extractive solution and/or volatile honeysuckle oil；

The dandelion extract is dandelion extracting solution and/or dandelion volatile oil；

The tripterygium glycosides extract is tripterygium glycosides extracting solution and/or tripterygium glycosides volatile oil；

The Herba Solidaginis extract is goldenrod extracting solution and/or goldenrod volatile oil；

The Herba Patriniae extract is field pennycress extracting solution and/or field pennycress volatile oil；

The Herba Violae extract is Chinese violet extracting solution and/or Chinese violet volatile oil；

The Rabdosia rubescens extract is Rabdosia rubescens extracting solution and/or Rabdosia rubescens volatile oil.

The second object of the present invention is to provide a kind of pharmaceutical preparation, which is used cooperatively with antibiotic, can While killing pathogen, additionally it is possible to it is scorching caused by the various diseases such as pneumonia, enteritis, mammitis and hysteritis to treat animal The symptoms such as disease, fever and pain, significant effect.

A kind of pharmaceutical preparation provided by the invention, including above-mentioned compound ketoprofen medicinal composition and pharmaceutically acceptable Auxiliary material；

Preferably, in the pharmaceutical preparation, weight percentage, including Ketoprofen 1-30%, Chinese medical extract 0.1-30%；

It is further preferred that in the pharmaceutical preparation, weight percentage, including Ketoprofen 10-20%, Chinese medicine carry Take object 10-20%.

Further, the pharmaceutical preparation is oral preparation, external preparation or injection.

Further, the oral preparation is granule, tablet, paste or oral administration solution；

Preferably, the pharmaceutical preparation is granule, and the auxiliary material includes filler and adhesive, is further preferably gone back Including at least one of cosolvent, corrigent and solvent；

Preferably, the pharmaceutical preparation is tablet, and the auxiliary material includes filler, adhesive and lubricant, further excellent It is selected as further including at least one of sour agent, alkaline agent, corrigent and solvent；

Preferably, the pharmaceutical preparation is paste, and the auxiliary material includes filler, adhesive, wetting agent and antioxidant, Further preferably further include corrigent and at least one of the preservatives；

Preferably, the pharmaceutical preparation be oral administration solution, the auxiliary material include cosolvent, antioxidant, pH adjusting agent and Solvent further preferably further includes corrigent and at least one of the preservatives.

Further, the pharmaceutical preparation be injection, the auxiliary material include cosolvent, antioxidant, pH adjusting agent and Solvent.

Further, the external preparation is ointment, gel, suppository, dip, hoof bath foam or spray；

Preferably, the pharmaceutical preparation be ointment, the auxiliary material include cosolvent, wetting agent, emulsifier, assistant for emulsifying agent, Oil phase and solvent；

Preferably, the pharmaceutical preparation is gel, and the auxiliary material includes cosolvent, wetting agent, antioxidant and solvent, into One step further includes preferably at least one of gel-type vehicle and gel auxiliary agent；

Preferably, the pharmaceutical preparation is suppository, and the auxiliary material includes suppository base, wetting agent, antioxidant and solvent；

Preferably, the pharmaceutical preparation be dip, hoof bath foam or spray, the auxiliary material include cosolvent, antioxidant, PH adjusting agent and solvent further preferably further include at least one of emollient, bleeding agent and convergence fungicide.

The third object of the present invention is to provide a kind of compound ketoprofen medicinal composition or pharmaceutical preparation is used in preparation Treat the application in the drug of animal pneumonia, enteritis, mammitis and hysteritis.

Compound ketoprofen medicinal composition or pharmaceutical preparation provided by the invention are being prepared for treating animal pneumonia, intestines Application in the drug of scorching, mammitis and hysteritis.

Compared with prior art, the invention has the advantages that：

Compound ketoprofen medicinal composition provided by the invention is using Ketoprofen and dandelion extract as primary raw material, each group / mutual coordinated, it is scorching caused by the various diseases such as pneumonia, enteritis, mammitis and hysteritis in treatment animal The symptoms such as disease, fever and pain have significant effect.

Pharmaceutical preparation provided by the invention is used cooperatively with antibiotic, while capable of killing pathogen, additionally it is possible to treat Animal symptoms such as inflammation, fever and pain caused by the various diseases such as pneumonia, enteritis, mammitis and hysteritis, effect are aobvious It writes.

When the pharmaceutical composition or pharmaceutical preparation of the present invention are used to treat animal pneumonia, enteritis, mammitis and hysteritis, with Antibiotic is used cooperatively, while capable of killing pathogen, additionally it is possible to treat animal due to pneumonia, enteritis, mammitis and uterus The symptoms such as inflammation, fever and pain, cure rate caused by scorching disease significantly improve.

Specific implementation mode

Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is The conventional products that can be obtained by commercially available purchase.

According to an aspect of the present invention, the present invention provides a kind of compound ketoprofen medicinal compositions, including following former Expect component：Ketoprofen and Chinese medical extract, the Chinese medical extract include dandelion extract.

Ketoprofen belongs to non-steroid anti-inflammatory drug (NSAIDs).NSAIDs be with hormone in contrast, because its chemistry knot Lack cyclopentanoperhydro-phenanthrene possessed by hormone in structure, so gaining the name, there is antipyretic, analgesia and anti-inflammatory effect.NSAIDs it mainly by can Inverse property inhibits the activity of cyclooxygenase (COXs), proinflammatory peptide or lipoxidase (LOXs), to inhibit to cause Inflammatory substances prostate The biosynthesis of element (PGs), leukotriene (LTs) and thromboxane (TXs) make bradykinin release reduce, and then it is good to play its Anti-inflammatory, analgesia and refrigeration function.

Dandelion extract is enriched the active ingredient in dandelion medicinal material, containing various active substance, and wherein phenolic acid Kind compound content is abundant, and especially caffeic acid and chlorogenic acid content is higher.With broad-spectrum antibacterial, lidan liver, antiendotoxin, The effects that stomach invigorating and Immune enhancement.For treating：Carbuncle that disappears dissipating bind, cure mainly acute mastitis, lung carbuncle, acute appendicitis, mumps, scrofula, boil poisonous soreness, Red eye, swell pain, cold, fever, property tonsillitis, acute bronchitis, cough, abscess of throat, acute mastitis, adenolymphitis, Gastritis, enteritis, dysentery, hepatitis, cholecystitis, urinary tract infections and snakebite and bugbite etc..

In one preferred embodiment, the mass ratio of the Ketoprofen and Chinese medical extract is (1-30)：(0.1- 30)；

Wherein, the mass ratio of Ketoprofen and Chinese medical extract such as can be, but be not limited to 1：0.1、5：5、5：10、5： 15、5：20、5：30、10：20、10：30、20：10、20：15、20：30 or 30：30.

Compound ketoprofen medicinal composition provided by the invention uses a certain proportion of Ketoprofen and with dandelion extract Chinese medicine composition for primary raw material is primary raw material, cooperates, influences each other between each component, have it is significant it is antipyretic, Analgesia and anti-inflammatory effect.

In one preferred embodiment, the Chinese medical extract further includes that Honegsukle flower P.E, tripterygium glycosides carry Take at least one of object, Herba Solidaginis extract, Herba Patriniae extract, Herba Violae extract and Rabdosia rubescens extract.

The main component of Honegsukle flower P.E is chlorogenic acid.Main pharmacological is as follows：(1) antibacterial and enhancing immune function Effect：Experiments have shown that honeysuckle is to typhoid bacillus, paratyphosum Bacterium, Escherichia coli, proteus, Pseudomonas aeruginosa, pertussis Bacillus, comma bacillus, staphylococcus, streptococcus, Diplococcus pneumopniae, meningococcus etc. have inhibiting effect.(2) inhibit drug resistance Mycoprotein matter synthesizes：Honegsukle flower P.E has notable stimulation to the breathing of staphylococcus aureus resistance plant, is chiefly used in Medicine and Surgery inflammation caused by antibody-resistant bacterium such as treats pulmonary tuberculosis complicated respiratory tract infection, pneumonia, acute bacillary dysentery, diarrhea, Also it is useful for reducing bottleneck throat bacterial bearing rate.

Tripterygium glycosides extract is root, leaf, the Hua Jiguo of Celastraceae tripterygium plant tripterygium wilfordii and Tripterygium regeli Real extract, main active have Diterpenes, triterpenes and alkaloids, these active constituents are also toxic component simultaneously. Nature and flavor bitter, acrid, cold, it is very toxic.For treating：Clearing heat and detoxicating, dispelling wind and eliminating dampness, clearing and activating the channels and collaterals, swelling and pain relieving, desinsection are antipruritic, use In rheumatoid arthritis, ephritis and multiple dermatosis, worm snake bite, tumour etc..

Herba Solidaginis extract is containing compounds such as flavonoids, saponin(es.For treating：Evacuate heat-clearing, removing toxicity for detumescence, acute pharynx Inflammation tonsillitis, carbuncle swells furunculosis, knife wound bleeding, gets ill from overeating, is abdominal distension vomiting, anemopyretic cold, mastitis, inguinal lymph adenoncus, small Youngster's acute infantile convulsions, migraine, infantile malnutrition due to digestive disturbances or intestinalparasites, the fungal infection of the hand, onychomycosis, the ringworm of the foot, traumatic injury, lung carbuncle, traumatic hemorrhage, multiple malignant boil is swollen, sends out Acute diseases such as cholera and sunstroke, heatstroke.General venomous snake bite, soft tissue strain and contusion, ulcer does not close up long after bursting, slough does not take off.

Herba Patriniae extract has the effects that antibacterial, anti-inflammatory, calm, antitumor.Clinically be used for treat chronic pelvic inflammatory disease, Colitis, prostatitis etc., the clearing heat and detoxicating, carbuncle that disappears lose purulence, stasis-dispelling and pain-killing.

Herba Violae extract is cold in nature, bitter, pungent, converge to heart and liver channels.For treating：Clearing heat and detoxicating, cool blood detumescence treats sore Pyogenic infections, ulcer carbuncle on the back, erysipelas, venomous snake bite.

Rabdosia rubescens extract is bitter in taste, sweet, is slightly cold.For treating：Clearing heat and detoxicating, anti-inflammatory analgetic, resists and swells stomach invigorating promoting blood circulation Tumor, bronchitis, tonsillitis, pharyngitis, pelvic infecton, cancer of the esophagus, liver cancer etc..

The Chinese medical extract of compound ketoprofen medicinal composition provided by the invention further includes Honegsukle flower P.E, tripterygium wilfordii At least one in more glucoside extracts, Herba Solidaginis extract, Herba Patriniae extract, Herba Violae extract and Rabdosia rubescens extract Kind, cooperate, influence each other between dandelion extract and Ketoprofen, can further increase it is antipyretic, analgesia and it is anti-inflammatory Effect, improve animal welfare, accelerate Animal diseases rehabilitation.

In a preferred embodiment of present embodiment, the dandelion extract, optional Honegsukle flower P.E, Optional tripterygium glycosides extract, optional Herba Solidaginis extract, optional Herba Patriniae extract, optional Chinese violet carry It is (1-10) to take the mass ratio of object and optional Rabdosia rubescens extract：(1-10)：(1-10)：(1-10)：(1-10)：(1-10)： (1-10), further preferably (2-8)：(2-8)：(2-8)：(2-8)：(2-8)：(2-8)：(2-8).

Wherein, dandelion extract, optional Honegsukle flower P.E, optional tripterygium glycosides extract, one optional The quality of day lily extract, optional Herba Patriniae extract, optional Herba Violae extract and optional Rabdosia rubescens extract Ratio such as can be, but be not limited to 1：1：1：1：1：1：1、2：2：2：3：3：3：3、3：3：3：4：4：4：4、2：2：3：3：4：4：4、 1：2：3：3：4：4：5 or 5：5：5：5：5：5：5、1：1：3：5：8：8：8、10：10：10：10：10：10：10.

In one preferred embodiment, the Honegsukle flower P.E is that Flos Lonicerae extractive solution and/or honeysuckle are volatilized Oil；

Extracting solution or volatilization of the Chinese medical extract of compound ketoprofen medicinal composition provided by the invention using Chinese medicine Oil is effectively retained the active constituent of Chinese medicine, helps to give full play to drug effect, improves antipyretic, analgesia and anti-inflammatory effect.

According to the second aspect of the invention, the present invention provides a kind of pharmaceutical preparations, including above-mentioned compound Ketoprofen medicine Compositions and pharmaceutically acceptable auxiliary material.

In one preferred embodiment, in the pharmaceutical preparation, weight percentage, including Ketoprofen 1- 30%, Chinese medical extract 0.1-30%.

Wherein, Ketoprofen for example can be, but be not limited to 1%, 5%, 10%, 15%, 20%, 25% or 30%；Chinese medicine Extract for example can be, but be not limited to 0.1%, 0.5%, 1%, 5%, 10%, 15%, 20%, 25% or 30%.

In a preferred embodiment of present embodiment, in the pharmaceutical preparation, weight percentage, including Ketoprofen 10-20%, Chinese medical extract 10-20%.

In one preferred embodiment, the pharmaceutical preparation is oral preparation, external preparation or injection.

Pharmaceutical preparation provided by the invention selects a variety of dosage forms, can be oral preparation, external preparation or injection, can It is quickly absorbed by animal body, helps to play drug effect.

In one preferred embodiment, the oral preparation is granule, tablet, paste or oral administration solution.

In a preferred embodiment of present embodiment, the pharmaceutical preparation is granule, and the auxiliary material includes filling out Agent and adhesive are filled, further preferably further includes at least one of cosolvent, corrigent and solvent.

Filler is the weight or volume for filler particles agent, so that granule is had certain weight and shape, is convenient for Molding, it is cost-effective.Filler for example can be, but be not limited to betadex, sucrose, converted starch or lactose.

Adhesive can make certain itself be glued together without the smaller drug powder of viscosity or viscosity.Adhesive for example may be used Think, but is not limited to alcohol, methylcellulose, PVP K30, polyvinylpyrrolidone K15 or starch slurry.

Cosolvent and insoluble drug form complex compound, associated matter or double salt etc. between shla molecule, to increase drug Solubility in a solvent.Cosolvent for example can be, but be not limited to arginine, histidine, methionine or meglumine.

Corrigent makes animal be difficult to perceive the strong hardship of drug to improve or shield adverse drug aroma and flavor Taste (or other peculiar smell it is for example pungent, stimulation etc.) pharmaceutic adjuvant.Flavouring agents such as can be, but be not limited to citric acid, A Si Batan, stevioside or medicinal essence (the savory essence of chicken gizzard or beef flavor).

The stable in physicochemical property of solvent can increase the solubility of drug, can be physiologically adapted with bodily tissue, inhale It receives fast.

In a preferred embodiment of present embodiment, the pharmaceutical preparation is granule, including following percentage contains The raw material components of amount：Ketoprofen 1-30%, Chinese medical extract 0.1-30%, filler 1-96%, adhesive 0.1-10%；

Preferably, further include the raw material components of following percentage composition：Cosolvent 0.1-30%, corrigent 0.1-5%, solvent 0.1-20%.

In a preferred embodiment of present embodiment, the pharmaceutical preparation is tablet, and the auxiliary material includes filling Agent, adhesive and lubricant further preferably further include at least one of sour agent, alkaline agent, corrigent and solvent.Filler It is the weight or volume for filling tablet, makes tablet that there is certain weight and shape, it is cost-effective convenient for molding.Filling Agent for example can be, but be not limited to betadex, sucrose, converted starch or lactose.

Lubricant can play the role of helping stream, anti-stick and lubrication, and frictional force is so as to improve powder between capable of reducing particle Last mobility；Supplementary material is prevented to be adhered to the surface of punch；Reduce the frictional force between preparation and punch die hole wall.Lubricant is for example It can be, but be not limited to magnesium stearate, taste powder silica gel or Macrogol 600.

Disintegrant of the sour agent as effervescent tablet, sour agent generate great amount of carbon dioxide after meeting water and make effervescent tablet with alkaline agent Agent is disintegrated rapidly so that drug effect is rapid, and bioavilability is high.Sour agent for example can be, but be not limited to fumaric acid, malic acid Or citric acid.

Disintegrant of the alkaline agent as effervescent tablet, alkaline agent generate great amount of carbon dioxide after meeting water and make effervescent tablet with sour agent Agent is disintegrated rapidly so that drug effect is rapid, and bioavilability is high.Alkaline agent for example can be, but be not limited to sodium carbonate, bicarbonate Sodium, potassium carbonate or saleratus.

Corrigent makes animal be difficult to perceive the strong bitterness of drug to improve or shield adverse drug aroma and flavor (or other peculiar smell it is for example pungent, stimulation etc.) pharmaceutic adjuvant.Flavouring agents such as can be, but be not limited to saccharin sodium, A Siba Smooth, stevioside or medicinal essence (the savory essence of chicken gizzard or beef flavor).

In a preferred embodiment of present embodiment, the pharmaceutical preparation is effervescent tablet, including following percentage The raw material components of content：Ketoprofen 1-30%, Chinese medical extract 0.1-30%, filler 1-96%, adhesive 0.1-10%, profit Lubrication prescription 0.1-10%, sour agent 0.1-5%, alkaline agent 0.1-5%；

Preferably, further include the raw material components of following percentage composition：Corrigent 0.1-5%, solvent 0.1-20%

In a preferred embodiment of present embodiment, the pharmaceutical preparation is paste, and the auxiliary material includes filling Agent, adhesive, wetting agent and antioxidant further preferably further include corrigent and at least one of the preservatives.

Filler is the weight or volume for filling paste, and paste is made to have certain weight and shape, convenient for being molded, It is cost-effective.Filler for example can be, but be not limited to betadex, sucrose, converted starch or lactose.

Adhesive can make certain itself be glued together without the smaller drug powder of viscosity or viscosity.Adhesive for example may be used Think, but is not limited to methylcellulose, PVP K30, polyvinylpyrrolidone K15 or starch slurry.

Wetting agent can reduce liquid-solid interfacial tension, increase the contact of liquid versus solid surfaces or increase the profit to the surface of solids Wet and extension substance.Wetting agent for example can be, but be not limited to propylene glycol, glycerine or polysorbate.

Antioxidant can protect drug ingedient oxidative damage and go bad.Antioxidant for example can be, but be not limited to Sodium sulfite or sodium thiosulfate.

Preservative can inhibit microbial activities, prevent drug ingedient putrid and deteriorated.Preservative for example can be, but be not limited to Methyl hydroxybenzoate, ethylparaben or propylben.

In a preferred embodiment of present embodiment, the pharmaceutical preparation is paste, including following percentage composition Raw material components：Ketoprofen 1-30%, Chinese medical extract 0.1-30%, filler 1-96%, adhesive 0.1-10%, wetting agent 0.1-10%, antioxidant 0.5-5%.

Preferably, further include the raw material components of following percentage composition：Corrigent 0.1-5%, preservative 0.1-5%

In a preferred embodiment of present embodiment, the pharmaceutical preparation is oral administration solution, and the auxiliary material includes Cosolvent, antioxidant, pH adjusting agent and solvent further preferably further include corrigent and at least one of the preservatives.

Cosolvent and insoluble drug form complex compound, associated matter or double salt etc. between shla molecule, to increase drug Solubility in a solvent.The cosolvent of granule for example can be, but be not limited to arginine, histidine, methionine, Portugal's first Amine, betadex, Tween 80, polyethylene glycol 400 or Macrogol 600.

Antioxidant can protect drug ingedient oxidative damage and go bad.Antioxidant for example can be, but be not limited to Sodium sulfite, sodium thiosulfate or EDTA-2Na.

PH adjusting agent is maintaining or change the substance of drug acid-base value.PH adjusting agent for example can be, but be not limited to hydrogen Sodium oxide molybdena.

Corrigent makes animal be difficult to perceive the strong bitterness of drug to improve or shield adverse drug aroma and flavor (or other peculiar smell it is for example pungent, stimulation etc.) pharmaceutic adjuvant.Flavouring agents such as can be, but be not limited to malt syrup.

Preservative can inhibit microbial activities, prevent drug ingedient putrid and deteriorated.Preservative for example can be, but be not limited to Benzoic acid, sodium benzoate, sorbic acid or potassium sorbate.

In a preferred embodiment of present embodiment, the pharmaceutical preparation is oral administration solution, including following percentage The raw material components of content：Ketoprofen 1-30%, Chinese medical extract 0.1-30%, cosolvent 1-30%, antioxidant 0.2-3%, PH adjusting agent 0.5-1%, surplus are solvent；

Preferably, further include the raw material components of following percentage composition：Corrigent 0.1-10%, preservative 0.1-5%.

In one preferred embodiment, the pharmaceutical preparation is injection, and the auxiliary material includes cosolvent, anti-oxidant Agent, pH adjusting agent and solvent.

Cosolvent and insoluble drug form complex compound, associated matter or double salt etc. between shla molecule, to increase drug Solubility in a solvent.Cosolvent for example can be, but be not limited to arginine, histidine, methionine, meglumine or his ring again Dextrin.

In a preferred embodiment of present embodiment, the pharmaceutical preparation is injection, including following percentage contains The raw material components of amount：Ketoprofen 1-30%, Chinese medical extract 0.1-30%, cosolvent 1-30%, antioxidant 0.2-3%, pH Conditioning agent 0.5-1%, surplus are solvent.

In one preferred embodiment, the external preparation is ointment, gel, suppository, dip, hoof bath foam or spray Agent.

In a preferred embodiment of present embodiment, the pharmaceutical preparation is ointment, and the auxiliary material includes hydrotropy Agent, wetting agent, emulsifier, assistant for emulsifying agent, oil phase and solvent.

Cosolvent and insoluble drug form complex compound, associated matter or double salt etc. between shla molecule, to increase drug Solubility in a solvent.Cosolvent for example can be, but be not limited to betadex.

Wetting agent can reduce liquid-solid interfacial tension, increase the contact of liquid versus solid surfaces or increase the profit to the surface of solids Wet and extension substance.Wetting agent for example can be, but be not limited to glycerine or polyethylene glycol 400.

Emulsifier can improve the various surface tension constituted between phase in emulsification system, form homogeneous dispersion or emulsified body Substance, also referred to as surfactant.Emulsifier for example can be, but be not limited to Tween 80 or sorbester p17.

Assistant for emulsifying agent is for increasing water phase or the viscosity of oil phase.Assistant for emulsifying agent for example can be, but be not limited to propylene glycol.

Oil phase for example can be, but be not limited to isopropyl myristate, vitamin E oil or albolene.

In a preferred embodiment of present embodiment, the pharmaceutical preparation is ointment, including following percentage composition Raw material components：Ketoprofen 1-30%, Chinese medical extract 0.5-20%, cosolvent 1-10%, wetting agent 1-20%, emulsifier 2- 30%, assistant for emulsifying agent 1-10%, oil phase 3-20%, surplus are solvent.

In one preferred embodiment, the pharmaceutical preparation be gel, the auxiliary material include cosolvent, wetting agent, Antioxidant and solvent further preferably further include at least one of gel-type vehicle and gel auxiliary agent.

The pharmaceutical preparation is gel, and the auxiliary material includes cosolvent, wetting agent, antioxidant and solvent, it is preferred that institute It further includes at least one of gel-type vehicle and gel auxiliary agent to state auxiliary material.

Wetting agent can reduce liquid-solid interfacial tension, increase the contact of liquid versus solid surfaces or increase the profit to the surface of solids Wet and extension substance.Wetting agent for example can be, but be not limited to glycerine.

Gel-type vehicle for example can be, but be not limited to carbomer 934 or Acritamer 940

Gel auxiliary agent for example can be, but be not limited to triethanolamine.

In a preferred embodiment of present embodiment, the pharmaceutical preparation is gel, including following percentage contains The raw material components of amount：It is Ketoprofen 1-30%, Chinese medical extract 0.5-20%, cosolvent 1-10%, wetting agent 1-20%, anti-oxidant Agent 0.5-5%, surplus are solvent；

Preferably, further include the raw material components of following percentage composition：Gel-type vehicle 0.1-5%, gel auxiliary agent 0.1-5%.

In a preferred embodiment of present embodiment, the pharmaceutical preparation is suppository, and the auxiliary material includes bolt Agent matrix, wetting agent, antioxidant and solvent.

The pharmaceutical preparation is suppository, and the auxiliary material includes suppository base, wetting agent, antioxidant and solvent.

Suppository base for example can be, but be not limited to carbomer 934, Acritamer 940, Macrogol 4000, polyethylene glycol 6000 or cetomacrogol 1000, glycerin monostearate, mixed aliphatic ester or polyoxyl 40 stearate.

Antioxidant can protect drug ingedient oxidative damage and go bad.Antioxidant for example can be, but be not limited to Sodium sulfite, sodium thiosulfate or vitamin E oil.

In a preferred embodiment of present embodiment, the pharmaceutical preparation is suppository, including following percentage composition Raw material components：It is Ketoprofen 1-30%, Chinese medical extract 0.5-20%, suppository base 1-60%, wetting agent 1-20%, anti-oxidant Agent 0.5-10%, surplus are solvent.

In a preferred embodiment of present embodiment, the pharmaceutical preparation is dip, hoof bath foam or spray, institute It includes cosolvent, antioxidant, pH adjusting agent and solvent to state auxiliary material, further preferably further includes emollient, bleeding agent and receipts Hold back at least one of fungicide.

Cosolvent and insoluble drug form complex compound, associated matter or double salt etc. between shla molecule, to increase drug Solubility in a solvent.Cosolvent for example can be, but be not limited to arginine, histidine, methionine, meglumine, times his ring Dextrin, Tween 80, polyethylene glycol 400 or Macrogol 600.

Emollient can help skin to keep soft, smooth and pliable appearance preparation.Emollient for example can be, but not It is limited to glycerine.

The ingredient that bleeding agent can help some both effectiveness penetrates into the cuticula of skin, plays effect.Bleeding agent is for example It can be, but be not limited to alcohol or Laurocapram.

Restraining fungicide has killing pathogen, also has astriction to wound.Restraining fungicide for example can be, but not It is limited to copper sulphate.

In a preferred embodiment of present embodiment, the pharmaceutical preparation is dip, hoof bath foam or spray, packet Include the raw material components of following percentage composition：It is Ketoprofen 1-30%, Chinese medical extract 0.1-30%, cosolvent 1-30%, anti-oxidant Agent 0.2-3%, pH adjusting agent 0.5-1%, surplus are solvent；

Preferably, further include the raw material components of following percentage composition：Emollient 0.1-20%, it bleeding agent 0.1-20%, receives Hold back fungicide 0.1-30%.

According to the third aspect of the present invention, the present invention provides a kind of compound ketoprofen medicinal composition or pharmaceutical preparations It is preparing for treating the application in animal pneumonia, enteritis, mammitis and the drug of hysteritis.

In order to contribute to the clearer understanding present invention, below in conjunction with embodiment and comparative example to the technical side of the present invention Case is described further.

Embodiment one

A kind of compound Ketoprofen oral solution is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 1%, dandelion extracting solution 30%, arginase 12 0%, betadex 5%, EDTA-2Na 1%, sodium sulfite 0.1%, Sodium hydroxide 0.5%, malt syrup 10%, sodium benzoate 5%, water for injection 27.4%.Wherein, Ketoprofen and Chinese medicine composition Mass ratio be 1：30.

Embodiment two

A kind of compound Ketoprofen oral solution is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 30%, dandelion volatile oil 0.1%, arginine 1%, histidine 10%, betadex 10%, EDTA-2Na 0.1%, sodium sulfite 1%, sodium hydroxide 1%, malt syrup 0.1%, benzoic acid 0.1%, water for injection 46.6%.Wherein, The mass ratio of Ketoprofen and Chinese medicine composition is 30：0.1.

Embodiment three

A kind of compound Ketoprofen oral solution is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 20%, dandelion extracting solution 10%, arginine 7.5%, meglumine 10%, methionine 10%, EDTA-2Na 0.2%, Asia Sodium sulphate 0.3%, sodium thiosulfate 0.5%, sodium hydroxide 0.6%, malt syrup 5%, potassium sorbate 3%, water for injection 32.9%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 20：10.

Example IV

A kind of compound Ketoprofen oral solution is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 5%, dandelion extracting solution 5%, arginine 3%, betadex 1%, EDTA-2Na 0.2%, sodium sulfite 0.5%, Sodium hydroxide 0.6%, malt syrup 5%, water for injection 79.7%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 5： 5。

Embodiment five

A kind of compound Ketoprofen oral solution is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 30%, dandelion extracting solution 5%, Chinese violet extracting solution 5%, field pennycress extracting solution 5%, arginine 10%, histidine 2%, betadex 0.5%, EDTA-2Na 0.2%, sodium thiosulfate 0.5%, sodium hydroxide 0.8%, malt syrup 5%, Potassium sorbate 0.5%, injection 35.5%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 30：15.Dandelion is extracted The mass ratio of liquid, Chinese violet extracting solution and field pennycress extracting solution is 5：5：5.

Embodiment six

A kind of compound Ketoprofen oral solution is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 30%, dandelion volatile oil 1%, volatile honeysuckle oil 1%, tripterygium glycosides volatile oil 1%, goldenrod volatile oil 1%, Rabdosia rubescens volatile oil 1%, arginine 5%, histidine 5%, betadex 5%, EDTA-2Na 0.8%, sodium sulfite 0.2%, sodium hydroxide 0.9%, malt syrup 2%, sodium benzoate 1%, water for injection 45.1%.Wherein, Ketoprofen and Chinese medicine The mass ratio of composition is 30：5, dandelion volatile oil, volatile honeysuckle oil, tripterygium glycosides volatile oil, goldenrod volatilization The mass ratio of oil and Rabdosia rubescens volatile oil is 1：1：1：1：1.

Embodiment seven

A kind of compound Ketoprofen oral solution is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 10%, dandelion extracting solution 5%, Flos Lonicerae extractive solution 2%, goldenrod extracting solution 1%, field pennycress extracting solution 1%, essence Propylhomoserin 15%, betadex 5%, EDTA-2Na 0.7%, sodium sulfite 0.5%, sodium hydroxide 0.5%, malt syrup 6%, potassium sorbate 2%, water for injection 50.3%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 10：10, dandelion Extracting solution, Flos Lonicerae extractive solution, goldenrod extracting solution and field pennycress extracting solution mass ratio be 5：2：1：1.

Embodiment eight

A kind of compound Ketoprofen oral solution is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 10%, dandelion extracting solution 6%, Flos Lonicerae extractive solution 2%, dandelion extracting solution 3%, tripterygium glycosides extracting solution 2%, Goldenrod extracting solution 2%, field pennycress extracting solution 3%, Chinese violet extracting solution 1%, Rabdosia rubescens extracting solution 1%, arginine 25%, EDTA-2Na 0.3%, sodium sulfite 0.4%, sodium hydroxide 0.6%, malt syrup 5%, sodium benzoate 4%, injection With water 34.7%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 10：20, dandelion extracting solution, Flos Lonicerae extractive solution, Dandelion extracting solution, tripterygium glycosides extracting solution, goldenrod extracting solution, field pennycress extracting solution, Chinese violet extracting solution and winter The mass ratio for insulting careless extracting solution is 6：2：3：2：2：3：1.

Embodiment nine

A kind of compound Ketoprofen oral solution is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 30%, dandelion volatile oil 10%, volatile honeysuckle oil 10%, goldenrod volatile oil 10%, arginine 4%, group ammonia Acid 2%, betadex 2%, EDTA-2Na 0.7%, sodium sulfite 0.4%, sodium hydroxide 0.4%, malt syrup 4%, benzene Formic acid 3%, water for injection 23.5%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 30：30, dandelion volatile oil, gold The mass ratio of honeysuckle flower volatile oil and goldenrod volatile oil is 10：10：10.

The preparation method for the compound Ketoprofen oral solution that embodiment one to nine is provided, includes the following steps：

(a) cosolvent is dissolved in solvent, 80r/min stirs 8-10min to being completely dissolved；

(b) preservative and antioxidant are added, 80r/min stirs 5-8min to being completely dissolved；

(c) Ketoprofen is added, 80r/min stirs 15-20min to being completely dissolved；

(d) Chinese medical extract and corrigent is added, stirs evenly；

(e) pH adjusting agent is added, adjusts pH value to 7.0 or so, constant volume sterilizes 121 DEG C, 30min flowing steam sterilizations, i.e., .

Embodiment ten

A kind of compound Ketoprofen granule is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 10%, dandelion extracting solution 10%, Flos Lonicerae extractive solution 6%, goldenrod extracting solution 3%, field pennycress extracting solution 1%, Lactose 42%, alcohol 2%, meglumine 25%, citric acid 1%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 10：20, Dandelion extracting solution, Flos Lonicerae extractive solution, goldenrod extracting solution and field pennycress extracting solution mass ratio be 10：6：3：1.

The preparation method for the compound Ketoprofen granule that embodiment ten is provided, includes the following steps：

(a) Ketoprofen, Chinese medical extract, filler, cosolvent and corrigent are sieved by 80 mesh respectively, then mixing is stirred 8-10min is mixed to being mixed thoroughly；

(b) spray adhesive while stirring into mixture, until making appropriate softwood, that is, that holds is agglomerating, touches i.e. It dissipates；

(c) by 30 mesh swinging screens, particle softwood is made；

(d) it is put into baking oven, 50 DEG C of drying 2h, whole grain to obtain the final product.

Embodiment 11

A kind of compound Ketoprofen effervescent tablet is present embodiments provided, the raw material components of following mass percentage are included： Ketoprofen 25%, dandelion extracting solution 3%, Flos Lonicerae extractive solution 3%, Chinese violet extracting solution 4%, field pennycress extracting solution 5%, Betadex 39.8%, alcohol 8%, polyvinylpyrrolidone K15 2%, Macrogol 6000 0.1%, citric acid 5%, Sodium bicarbonate 5%, stevioside 0.1%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 25：15, dandelion extracting solution, The mass ratio of Flos Lonicerae extractive solution, Chinese violet extracting solution and field pennycress extracting solution is 3：3：4：5.

The preparation method for the compound Ketoprofen effervescent tablet that embodiment 11 is provided, includes the following steps：

(a) Ketoprofen, Chinese medical extract, filler, lubricant, sour agent, alkaline agent and corrigent are sieved by 80 mesh respectively, Then solvent is added, 8-10min is mixed to being mixed thoroughly；

(b) adhesive is added while stirring into mixture, until making appropriate softwood, that is, that holds is agglomerating, touches i.e. It dissipates；

(c) by 30 mesh swinging screens, particle softwood is made；

(d) it is put into baking oven, 50 DEG C of drying 2h, with tabletting machine to obtain the final product.

Embodiment 12

A kind of compound Ketoprofen paste is present embodiments provided, the raw material components of following mass percentage are included：Ketone Lip river Sweet smell 10%, dandelion extracting solution 5%, Flos Lonicerae extractive solution 5%, Rabdosia rubescens extracting solution 5%, converted starch 49.4%, methyl are fine Dimension element 10%, glycerine 10%, antioxidant 0.5%, aspartame 5%, methyl hydroxybenzoate 0.1%.Wherein, Ketoprofen and Chinese medicine The mass ratio of composition is 10：15, the mass ratio of dandelion extracting solution, Flos Lonicerae extractive solution and Rabdosia rubescens extracting solution is 5：5：5.

The preparation method for the compound Ketoprofen paste that embodiment 12 is provided, includes the following steps：

(a) Ketoprofen, Chinese medical extract, filler, adhesive and corrigent are sieved by 80 mesh respectively, is then added molten 8-10min is mixed to being mixed thoroughly in agent；

(b) lubricant and preservative is added while stirring into mixture, is mixed evenly to obtain the final product.

Embodiment 13

A kind of compound Ketoprofen injection is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 5%, dandelion extracting solution 5%, arginine 3%, betadex 1%, EDTA-2Na 0.2%, sodium sulfite 0.5%, Sodium hydroxide 0.6%, water for injection 84.7%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 5：5.

Embodiment 14

A kind of compound Ketoprofen injection is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 30%, dandelion volatile oil 5%, Chinese violet volatile oil 5%, field pennycress volatile oil 5%, arginine 10%, meglumine 3%, betadex 5%, EDTA-2Na 0.2%, sodium thiosulfate 0.2%, sodium hydroxide 1%, water for injection 35.6%. Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 30：15, dandelion volatile oil, Chinese violet volatile oil and field pennycress are waved The mass ratio of hair oil is 5：5：5.

The preparation method for the compound Ketoprofen injection that embodiment 13 to 14 is provided, includes the following steps：

(b) antioxidant is added, 80r/min stirs 5-8min to being completely dissolved；

(d) Ketoprofen is added, 80r/min stirs 15-20min to being completely dissolved；

(e) Chinese medical extract is added, stirs evenly；

(f) pH adjusting agent is added, adjusts pH value to 7.0 or so, constant volume sterilizes 121 DEG C, 30min flowing steam sterilizations, i.e., .

Embodiment 15

A kind of compound Ketoprofen ointment is present embodiments provided, the raw material components of following mass percentage are included：Ketone Lip river Sweet smell 10%, dandelion extracting solution 10%, betadex 6%, polyethylene glycol 400 5%, Tween 80 5%, sorbester p17 5%, Propylene glycol 5%, isopropyl myristate 5%, vitamin E oil 2%, albolene 5%, water for injection 42%.Wherein, Ketoprofen Mass ratio with Chinese medicine composition is 10：10.

The preparation method for the compound Ketoprofen ointment that embodiment 15 is provided, includes the following steps：

(a) by emulsifier, help emulsion and oil phase to mix, be heated to 60 DEG C, 80r/min stirs 8-10min to substantially uniformity, It keeps the temperature spare；

(b) solvent is heated to 60-80 DEG C, is added cosolvent, 100r/min stirs 8-10min to being completely dissolved；

(c) Ketoprofen and Chinese medical extract, 70 DEG C of heat preservations are added into (b) item solution, 120r/min stirs 10-15min To being completely dissolved；

(d) wetting agent is added into (c) item solution, 8-10min is to substantially uniformity for 80r/min stirrings, spare；

(e) (d) item solution is added in (a) item, low speed 60r/min is stirred until homogeneous lotion, is cooled to 40 DEG C into ointment.

Embodiment 16

A kind of compound ketoprofen gel is present embodiments provided, the raw material components of following mass percentage are included：Ketone Lip river Sweet smell 20%, dandelion extracting solution 5%, tripterygium glycosides liquid 5%, Chinese violet extracting solution 5%, Rabdosia rubescens extracting solution 5%, times he Cyclodextrin 6%, glycerine 5%, sodium sulfite 0.5%, carbomer 934 1%, triethanolamine 0.6%, purified water 56.9%.Its In, wherein the mass ratio of Ketoprofen and Chinese medicine composition is 20：20, dandelion extracting solution, tripterygium glycosides liquid, Chinese violet The mass ratio of extracting solution and Rabdosia rubescens extracting solution is 5：5：5：5.

The preparation method for the compound ketoprofen gel that embodiment 16 is provided, includes the following steps：

(a) it takes solvent to stay overnight swell gel matrix, gel auxiliary agent is added, 60r/min is stirred to clear gel matrix；

(b) it heats water to 60-80 DEG C, is added cosolvent, 100r/min stirs 8-10min to being completely dissolved；

(c) Ketoprofen and Chinese medical extract, 70 DEG C of heat preservations are added, 120r/min stirs 10-15min to being completely dissolved；

(d) solution is stopped heating, addition wetting agent and antioxidant, 80r/min stirring 8-10min to substantially uniformity, It is spare；

(e) by (d) item solution be added (a) item in, low speed 60r/min be stirred until homogeneous to get.

Embodiment 17

A kind of compound Ketoprofen suppository is present embodiments provided, the raw material components of following mass percentage are included：Ketone Lip river Sweet smell 15%, Chinese medical extract 15%, polyoxyl 40 stearate 35%, glycerine 10%, vitamin E oil 3%, sodium sulfite 0.2%, purified water 21.8%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 15：15.

The preparation method for the compound Ketoprofen suppository that embodiment 17 is provided, includes the following steps：

(a) suppository base is heated to 70 DEG C of fusings；

(b) Ketoprofen, antioxidant and Chinese medical extract are added in wetting agent and are ground uniformly；

(c) (b) item mixture is added in (a) item, stirs evenly, pour into bolt mould, cooling strikes off and takes out to obtain the final product.

Embodiment 18

A kind of compound Ketoprofen dip is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 10%, dandelion extracting solution 5%, tripterygium glycosides extracting solution 5%, goldenrod extracting solution 5%, arginine 5%, poly- second Glycol 400 1%, Tween 80 1%, EDTA-2Na 0.2%, sodium sulfite 0.5%, sodium hydroxide 0.6%, glycerine 5%, wine Essence 3%, water for injection 58.7%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 10：15.

The preparation method for the compound Ketoprofen dip that embodiment 18 is provided, includes the following steps：

(b) antioxidant is added, 80r/min stirs 5-8min to being completely dissolved；

(d) Chinese medical extract is added to stir evenly；

(e) emollient, bleeding agent and convergence fungicide is added to stir evenly；

(f) pH adjusting agent is added and adjusts pH value to 7.0 or so, constant volume sterilizes 121 DEG C, 30min flowing steam sterilizations, i.e., .

Embodiment 19

A kind of compound Ketoprofen hoof bath foam is present embodiments provided, the raw material components of following mass percentage are included：Ketone Ibuprofen 10%, dandelion extracting solution 5%, tripterygium glycosides extracting solution 5%, goldenrod extracting solution 5%, arginine 5%, tween 80 1%, sodium thiosulfate 0.5%, sodium hydroxide 0.6%, alcohol 3%, Laurocapram 0.5%, copper sulphate 5%, injection Water 59.4%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 10：15.

The preparation method for the compound Ketoprofen hoof bath foam that embodiment 19 is provided, the compound provided with embodiment 18 The preparation method of Ketoprofen dip is identical.

Embodiment 20

A kind of compound Ketoprofen spray is present embodiments provided, the raw material components of following mass percentage are included：Ketone Lip river Sweet smell 10%, dandelion extracting solution 5%, goldenrod extracting solution 2%, field pennycress extracting solution 3%, Chinese violet extracting solution 2%, essence Propylhomoserin 5%, Tween 80 1%, Macrogol 600 1%, sodium thiosulfate 0.5%, sodium hydroxide 0.6%, alcohol 3%, bay Azone 0.5%, copper sulphate 5%, water for injection 61.4%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 10：12.

The preparation method for the compound Ketoprofen spray that embodiment 20 is provided, the compound ketone provided with embodiment 18 The preparation method of ibuprofen dip is identical.

Comparative example one

This comparative example provides a kind of compound Ketoprofen oral solution, is extracted without containing dandelion unlike embodiment three Object.

This comparative example provides a kind of compound Ketoprofen oral solution, including the following raw material component：Ketoprofen 20%, arginine 7.5%, meglumine 10%, methionine 10%, EDTA-2Na 0.2%, sodium sulfite 0.3%, sodium thiosulfate 0.5%, hydrogen-oxygen Change sodium 0.6%, malt syrup 5%, potassium sorbate 3%, water for injection 42.9%.

Comparative example two

This comparative example provides a kind of compound Ketoprofen oral solution, and Ketoprofen is not contained unlike embodiment three.

Present embodiments provide a kind of compound Ketoprofen oral solution, including the following raw material component：Dandelion extracting solution 10%, Arginine 7.5%, meglumine 10%, methionine 10%, EDTA-2Na0.2%, sodium sulfite 0.3%, sodium thiosulfate 0.5%, sodium hydroxide 0.6%, malt syrup 5%, potassium sorbate 3%, water for injection 52.9%.Wherein, Ketoprofen and Chinese medicine The mass ratio of composition is 20：10.

Comparative example three

This comparative example provides a kind of compound Ketoprofen oral solution, and Ketoprofen and dandelion carry unlike embodiment three Take the mass ratio of object not within protection scope of the present invention.

This comparative example provides a kind of compound Ketoprofen oral solution, including the following raw material component：Ketoprofen 0.5%, Pu Gong English extracting solution 35%, arginine 7.5%, meglumine 10%, methionine 10%, EDTA-2Na 0.2%, sodium sulfite 0.3%, Sodium thiosulfate 0.5%, sodium hydroxide 0.6%, malt syrup 5%, potassium sorbate 3%, water for injection 32.4%.Wherein, ketone The mass ratio of ibuprofen and Chinese medicine composition is 0.5：35.

Comparative example four

This comparative example provides a kind of compound Ketoprofen oral solution, each group of Chinese medical extract unlike embodiment seven Point mass ratio not within protection scope of the present invention.

This comparative example provides a kind of compound Ketoprofen oral solution, including the following raw material component：Ketoprofen 10%, dandelion Extracting solution 16.5%, Flos Lonicerae extractive solution 0.5%, dandelion extracting solution 0.5%, tripterygium glycosides extracting solution 0.5%, solidago plant Flower extracting solution 0.5%, field pennycress extracting solution 0.5%, Chinese violet extracting solution 0.5%, Rabdosia rubescens extracting solution 0.5%, arginine 25%, EDTA-2Na 0.3%, sodium sulfite 0.4%, sodium hydroxide 0.6%, malt syrup 5%, sodium benzoate 4%, injection With water 34.7%.Wherein, the mass ratio of Ketoprofen and Chinese medicine composition is 10：20, dandelion extracting solution, Flos Lonicerae extractive solution, Dandelion extracting solution, tripterygium glycosides extracting solution, goldenrod extracting solution, field pennycress extracting solution, Chinese violet extracting solution and winter The mass ratio for insulting careless extracting solution is 16.5：0.5：0.5：0.5：0.5：0.5：0.5.

The preparation method for the compound Ketoprofen oral solution that comparative example one to four is provided, the compound provided with embodiment three The preparation method of Ketoprofen oral solution is identical.

Pharmaceutical stability is tested

The pharmaceutical preparation of each embodiment and comparative example is taken to carry out strong illumination experiment under the conditions of 4500 ± 500lx respectively, Hot test, each group test result such as table are carried out under conditions of taking the pharmaceutical preparation of each embodiment and comparative example to be placed in 60 DEG C respectively Shown in 1.

1 test result of table

By data in table 1 it is found that the pharmaceutical preparation that the embodiment of the present invention one to 20 is provided tests 5 by strong illumination It, 10 days, after 15 days, still maintain original character；PH stablizes, and is maintained at 6.0-8.0；It is not infected by bacterial, remains as Germ-free condition.There is muddiness, very to some extent after strong illumination is tested in the pharmaceutical preparation that comparative example one to four is provided Occur to there is layering.

The pharmaceutical preparation that the embodiment of the present invention one to 20 is provided is after hot test 5 days, 10 days, 15 days, still Keep original character；PH stablizes, and is maintained at 6.0-8.0；It is not infected by bacterial, remains as germ-free condition.Comparative example one to There is muddiness to some extent after hot test in four pharmaceutical preparations provided, or even have layering to occur.

Clinical effect trial

2.1 experiments prepare

Infected cattle inclusion criteria：It is that the milk cow in lactation period breast with actual clinical type mammitis has a tidal wave of through clinical diagnosis The clinical symptoms etc. of red, swelling, fever and pain.

Experiment grouping and administration：90 experiment milk cows are assigned to 6 test groups by random, every group 15, as possible Keep the morbidity severity of every group of milk cow almost the same.

Test method：The application method of compound Ketoprofen oral solution：Gavage milk (is calculated) with Ketoprofen by 5mg/kgbw Ox 1 day 1 time, is used in conjunction 3 days；The application method of compound Ketoprofen injection：Muscle (is calculated) with Ketoprofen by 3mg/kgbw (neck) injection system is administered, and 1 day 1 time, is used in conjunction 3 days；The application method of compound Ketoprofen dip：Using cow breast tissue It is whole to impregnate, it 1 day 2 times, each 10-15min, is used in conjunction 3 days；The application method of control group Cefquinome sulfate：It is noted using breast Enter agent (lactation period) 1 time 1, interval 12h is administered once, is used in conjunction 6 times.The specific drug administration information of each group is as shown in table 2.Entire experiment Period, all experiment milk cows no longer give any other antibacterials and anti-inflammatory drug.

The experiment of table 2 grouping and administration

2.2 infected cattle clinicing symptom observations and evaluation

Before first 0 day of administration, each administration, the 1st, 3,7,14 day after last time administration, the spirit of milk cow is observed Situation, breast local symptom, milk character, and given a mark according to following symptom scores standards, symptom scores mark It is accurate as shown in table 3.

3 symptom scores standard of table

2.3 daily yieldings and the detection of somatic cell from milk number

The the 3rd, 7,14 day after first 0 day of administration, last time administration, the daily yielding of milk cow is counted, and be administered First 0 day, last time be administered after the 7th day, 14 days acquisition milk sample about 50ml use QSCC methods, with somatic cell counting instrument in milk sample Body cell counted.

The acquisition and separation of pathogen in 2.4 milk samples

Milk sample acquires：The 7th day and the 14th day after being administered before administration with last time within 0 day, milk sample was acquired respectively.Sampling Preceding first to be carried out disinfection with disinfecting towel wiping nipple, manual milking discards first three milk, and ox is collected with sterile centrifugation tube by each breast area Milk 5mL-10mL is placed in ice chest preservation, and label send rapidly laboratory, carries out bacterium and is separately cultured.

The separation of pathogen：Will acquisition milk sample shake up, while it is sterile absorption in right amount be inoculated in ordinary nutrient agar culture medium, Blood agar culture-medium, EMB agar medium, maconkey agar culture medium, mannite agar culture medium with high salt, are placed in 37 24-48h is cultivated respectively in DEG C incubator.The case where observing bacterial growth in each tablet records ne ar.According to the life of bacterium Whether long situation, haemolysis, picking single bacterium colony carries out further scribing line separation, 37 DEG C of culture 18- of tablet respectively for colonial morphology etc. 48h carries out Gram's staining, observes ne ar and classification.Nutrient broth culture of the bacterial strain of acquisition containing 30% glycerine Base, -20 DEG C of preservations.

Test results and analysis

3.1 experiment infected cattle clinical manifestations

Observe all infected cattles 0 day before administration, every time before administration, last time be administered after the 1st, 3,7,14 day spiritual shape Condition, breast local symptom, milk character score to it by 5 standard of table.To each group test milk cow breast local symptom, Milk character, mental status scoring are for statistical analysis, are as a result shown in Table 4, table 5, table 6 respectively.

4 different time experimental tests cow breast local symptom appraisal result of table counts

Note：Has identical lowercase letter indication difference significantly (p≤0.05)；" * " indicates significant difference (p≤0.05).

By data in table 4 it is found that the pharmaceutical preparation using the present invention and the acute breast after Cefquinome sulfate combination treatment Room inflammation milk cow can fast and effeciently improve the breast local symptom of milk cow.

5 different time experimental tests dairy cow milk character appraisal result of table counts

By data in table 5 it is found that the pharmaceutical preparation using the present invention and the acute breast after Cefquinome sulfate combination treatment Room inflammation milk cow can fast and effeciently improve the milk character of milk cow.

6 different time experimental tests milk cow state of mind appraisal result of table counts

By data in table 6 it is found that the pharmaceutical preparation using the present invention and the acute breast after Cefquinome sulfate combination treatment Room inflammation milk cow can fast and effeciently improve the state of mind of milk cow.

3.2 experiment infected cattle daily yieldings and somatic cell from milk number statistical result

The the 3rd, 7,14 day after first 0 day of administration, last time administration, the daily yielding of milk cow is counted, and be administered First 0 day, last time be administered after the 7th day, 14 days acquisition milk sample about 50ml use QSCC methods, with somatic cell counting instrument in milk sample Body cell counted.Milk milk crop record sheet, dairy cow milk somatic number record sheet, statistical result are shown in Table 7, table 8.

The 7 different time experimental tests milk cow daily output of table counts (kg)

Note：" * " indicates that significant difference (p≤0.05), " * * " indicate difference extremely significantly (p≤0.01).

By data in table 7 it is found that the pharmaceutical preparation using the present invention and the acute breast after Cefquinome sulfate combination treatment Room inflammation milk cow can fast and effeciently improve the daily yielding of milk cow.

8 different time experimental tests dairy cow milk somatic number of table counts (ten thousand)

Note：" * " indicates significant difference (p≤0.05).

By data in table 8 it is found that the pharmaceutical preparation using the present invention and the acute breast after Cefquinome sulfate combination treatment Room inflammation milk cow, can be effectively reduced dairy cow milk somatic number.

Pathogen inspection result in 3.3 milk samples

Test detection of pathogens result in the preceding milk sample of infected cattle administration

(administration 0 day) and drug withdrawal acquire medication breast area milk sample in 7 days, 14 days respectively before administration, and laboratory is sent to carry out bacterium It is separately cultured.It the results are shown in Table 9.

(0 day), drug withdrawal are tested pathogen recall rate in infected cattle milk sample for 7 days, 14 days and are counted before table 9 is administered

Note：1) n values indicate that the time point collects the case load of data in bracket.2) " G- " indicates Gram-negative bacteria, " G + " indicate gram-positive bacteria.

By data in table 9 it is found that the pharmaceutical preparation using the present invention and the acute breast after Cefquinome sulfate combination treatment Room inflammation milk cow can effectively kill the pathogen in infected cattle body.

3.4 curative effects compare

During administration is extremely discontinued 14 days for 0 day, the breast local symptom of each infected cattle of integrated survey, milk character, spiritual shape The indices such as pathogen detection situation, each experiment is judged by standard respectively in state, daily yielding and somatic cell from milk number, milk sample Infected cattle presses the curative effect after default dosage regimen treatment.The cure rate, effective percentage and inefficiency for counting two groups of infected cattles, the results are shown in Table 10。

The effect of 10 test ox different dosing group of table, counts

Note：1) efficient (%)=(treating effective ox number+healing ox number)/group in test ox number × 100；Cure rate (%) =(cure ox number)/group in test ox number × 100；Inefficiency (%)=(the invalid ox number for the treatment of)/group in test ox number × 100. 2) has identical lowercase letter indication difference significantly (p≤0.05).

By data in table 10 it is found that the pharmaceutical preparation using the present invention and the acute breast after Cefquinome sulfate combination treatment Room inflammation milk cow, cure rate are significant in efficacy up to 86.67% or more.

In conclusion the pharmaceutical preparation of the present invention with antibiotic for when treating mammitis of animal, being used cooperatively, can kill Go out pathogen while, additionally it is possible to treat the animal symptoms such as inflammation, fever and pain, cure rate caused by mammitis disease Height, it is significant in efficacy.

The dosage form not provided in clinical effect trial all has technique effect similar with above-mentioned dosage form, no longer superfluous herein It states.

Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution The range of scheme.

Claims

1. a kind of compound ketoprofen medicinal composition, which is characterized in that including the following raw material component：Ketoprofen and traditional Chinese medicine extraction Object, the Chinese medical extract include dandelion extract.

2. compound ketoprofen medicinal composition according to claim 1, which is characterized in that the Ketoprofen and traditional Chinese medicine extraction The mass ratio of object is (1-30)：(0.1-30)；

3. compound ketoprofen medicinal composition according to claim 1 or 2, which is characterized in that the Chinese medical extract is also Including Honegsukle flower P.E, tripterygium glycosides extract, Herba Solidaginis extract, Herba Patriniae extract, Herba Violae extract At least one of with Rabdosia rubescens extract；

Preferably, the dandelion extract, optional Honegsukle flower P.E, optional tripterygium glycosides extract, optional one The matter of branch day lily extract, optional Herba Patriniae extract, optional Herba Violae extract and optional Rabdosia rubescens extract Amount is than being (1-10)：(1-10)：(1-10)：(1-10)：(1-10)：(1-10)：(1-10), further preferably (2-8)：(2- 8)：(2-8)：(2-8)：(2-8)：(2-8)：(2-8).

4. compound ketoprofen medicinal composition according to claim 3, which is characterized in that the Honegsukle flower P.E is gold Honeysuckle flower extracting solution and/or volatile honeysuckle oil；

5. a kind of pharmaceutical preparation, which is characterized in that include claim 1-4 any one of them compound ketoprofen medicinal compositions With pharmaceutically acceptable auxiliary material；

Preferably, in the pharmaceutical preparation, weight percentage, including Ketoprofen 1-30%, Chinese medical extract 0.1- 30%；

It is further preferred that in the pharmaceutical preparation, weight percentage, including Ketoprofen 10-20%, Chinese medical extract 10-20%.

6. pharmaceutical preparation according to claim 5, which is characterized in that the pharmaceutical preparation is oral preparation, external preparation Or injection.

7. pharmaceutical preparation according to claim 6, which is characterized in that the oral preparation be granule, tablet, paste or Oral administration solution；

Preferably, the pharmaceutical preparation is granule, and the auxiliary material includes filler and adhesive, further preferably further includes At least one of cosolvent, corrigent and solvent；

Preferably, the pharmaceutical preparation is tablet, and the auxiliary material includes filler, adhesive and lubricant, further preferably Further include at least one of sour agent, alkaline agent, corrigent and solvent；

Preferably, the pharmaceutical preparation is paste, and the auxiliary material includes filler, adhesive, wetting agent and antioxidant, into one Step further includes preferably corrigent and at least one of the preservatives；

Preferably, the pharmaceutical preparation is oral administration solution, and the auxiliary material includes cosolvent, antioxidant, pH adjusting agent and solvent, Further preferably further include corrigent and at least one of the preservatives.

8. pharmaceutical preparation according to claim 6, which is characterized in that the pharmaceutical preparation is injection, the accessory package Include cosolvent, antioxidant, pH adjusting agent and solvent.

9. pharmaceutical preparation according to claim 6, which is characterized in that the external preparation is ointment, gel, suppository, medicine Bath foam, hoof bath foam or spray；

Preferably, the pharmaceutical preparation is ointment, and the auxiliary material includes cosolvent, wetting agent, emulsifier, assistant for emulsifying agent, oil phase And solvent；

Preferably, the pharmaceutical preparation is gel, and the auxiliary material includes cosolvent, wetting agent, antioxidant and solvent, further Preferably further include at least one of gel-type vehicle and gel auxiliary agent；

Preferably, the pharmaceutical preparation is dip, hoof bath foam or spray, and the auxiliary material includes cosolvent, antioxidant, pH tune Agent and solvent are saved, further preferably further includes at least one of emollient, bleeding agent and convergence fungicide.

10. a kind of claims require 1-4 any one of them pharmaceutical composition or claim 5-9 any one of them medicines Object preparation is being prepared for treating the application in animal pneumonia, enteritis, mammitis and the drug of hysteritis.