CN108478485A - 一种温敏型水凝胶面膜及其制备方法 - Google Patents
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Abstract
本发明提供了一种温敏型水凝胶面膜及其制备方法,该面膜通过喷涂使用,水凝胶的固化温度控制在30‑35℃,满足人体面部温度条件下的胶凝化,不仅有利于水分的保持,对活性成分的吸收也具有促进作用;而通过尿囊素与丙二醇的联合使用还起到了促进活性成分渗透的作用。
Description
技术领域
本发明涉及化妆品领域,尤其涉及水凝胶面膜领域。
背景技术
面膜主要包括基质和活性成分两大部分。其中基质即为面膜的载体,常用的基质有水凝胶、无纺布等;营养成分则多种多样,例如动植物提取物、氨基酸、精油等。粉状面膜为一种细腻、均匀、无杂质的混合粉末状物质,对皮肤无刺激,使用时将适量的面膜粉末与水调合成糊状,涂敷于面部,随着水分的蒸发,在面部形成一层较厚的膜状物;膏状面膜大多含有较多的黏土类成分(如高岭土、硅藻土等)、润肤剂油性成分以及各种护肤功能性成分等,使用时也是直接涂敷于面部,使用后一般不能成膜剥离,需用吸水海绵擦洗;剥离面膜一般为软膏状和凝胶状,使用时将面膜涂敷于面部,待其干后将其揭去,面部的污垢、皮屑也粘附在面膜上同时被揭去,达到清洁皮肤的目的;成型面膜,是将面膜液浸入无纺布类的基质上,使用时只需将布贴牢于面部,经15-20分钟后,面膜液逐渐被吸收干燥,将布取下即可。成型面膜因其使用方便简单受到消费者的青睐,是目前使用最为广泛的一类面膜。
现有面膜存如下问题:(1)成型面膜因形状固定,使用时无法完全贴合每个人的面部,特别是在眼下部,鼻翼周边以及嘴两侧部位,不能很好地与皮肤贴合;(2)成型面膜的基质多为无纺布,其在湿态下的韧性和贴肤性不高,使用时要求面部必须保持静止,一旦有张弛作用就会造成面膜脱离皮肤。(3)成型面膜中承担营养作用的面膜液的粘度通常都比较低,其粘度低于膏状面膜和剥离面膜中的软膏和凝胶的粘度,在使用过程中面膜液容易洒落和流向颈部;(4)泥膏状面膜清洁力度较强,但使用后需用清水清洗;(5)现有的喷涂面膜存在皮肤有益成分吸收程度低的问题。
发明内容
为了解决上述技术问题,本发明提供了一种温敏型的水凝胶面膜。
本发明提供了一种温敏型水凝胶面膜,其特点是包含如下组分:凝胶基质、乳酸、尿囊素、保湿剂、防腐剂,生物活性分子。
进一步,凝胶基质包含温敏型凝胶材料,选自壳聚糖、透明质酸、可溶性丝素蛋白、羟丙甲基纤维素、聚乙烯醇中的一种或组合;
进一步,保湿剂选自甘油、丙二醇、山梨醇中的一种或组合;
进一步,防腐剂选自羟苯甲酯、羟苯丙酯中的一种或两种组合;
进一步,生物活性分子选自表皮生长因子、北美金缕梅提取物、酵母提取物、抗坏血酸、茶多酚中的一种或组合;
本发明进一步提供了一种温敏型水凝胶面膜,包含如下组分:壳聚糖、透明质酸、可溶性丝素蛋白、尿囊素、乳酸、甘油、丙二醇、表皮生长因子、羟苯甲酯,余量为水;
本发明进一步提供了一种温敏型水凝胶面膜,以重量百分比计,包含如下组分:壳聚糖1-5%、透明质酸0.5-2%、可溶性丝素蛋白0.5-2%、尿囊素0.01-0.02%、乳酸0.1-0.2%、甘油0.3-0.6%、丙二醇0.5-1%、表皮生长因子0-0.001%、羟苯甲酯0-0.01%,余量为水;
本发明进一步提供了一种温敏型水凝胶面膜,以重量百分比计,包含如下组分:壳聚糖2%、透明质酸1%、可溶性丝素蛋白1%、尿囊素0.02%、乳酸0.2%、甘油0.6%、丙二醇1%、表皮生长因子0.001%、羟苯甲酯0.01%,余量为水;
本发明进一步提供了一种温敏型水凝胶面膜的制备方法:将乳酸溶于水,配制2%的乳酸溶液,加入壳聚糖(90%脱乙酰度),加热至50℃,搅拌溶解;依次加入尿囊素、甘油、丙二醇,冷却至20℃以下,得混合溶液A;将透明质酸、可溶性丝素蛋白、表皮生长因子、羟苯甲酯溶于剩余水中,加热至50℃,搅拌,使完全溶解,冷却至20℃以下,得混合溶液B;将溶液B缓慢加入到溶液A中,搅拌,高速剪切,使混合均匀,得水凝胶面膜溶液;将水凝胶面膜溶液填充到喷雾瓶中,得产品。
本发明具有以下有益效果:
本发明面膜通过喷涂使用,通过联合使用壳聚糖、透明质酸、可溶性丝素蛋白使得水凝胶的固化温度控制在30-35℃,以满足在人体面部温度条件下的胶凝化,不仅有利于水分的保持,对活性成分的吸收也具有促进作用;而尿囊素的加入不仅起到了保持水分、促进细胞增长,新陈代谢,软化角质的作用,本发明还发现了通过尿囊素与丙二醇的联合使用还起到了促进活性成分渗透的作用。
具体实施方式
下面结合实施例对本发明做进一步的说明。
实施例1
一种温敏型水凝胶面膜,以重量百分比计,组分如下:壳聚糖2%、透明质酸1%、可溶性丝素蛋白1%、尿囊素0.02%、乳酸0.2%、甘油0.6%、丙二醇1%、表皮生长因子0.001%、羟苯甲酯0.01%,余量为水;
制备方法如下:准确称取上述组分,将乳酸溶于水,配制2%的乳酸溶液,加入壳聚糖(90%脱乙酰度),加热至50℃,搅拌溶解;依次加入尿囊素、甘油、丙二醇,冷却至20℃以下,得混合溶液A;将透明质酸、可溶性丝素蛋白、表皮生长因子、羟苯甲酯溶于剩余水中,加热至50℃,搅拌,使完全溶解,冷却至20℃以下,得混合溶液B;将溶液B缓慢加入到溶液A中,搅拌,高速剪切,使混合均匀,得水凝胶面膜溶液;将水凝胶面膜溶液填充到喷雾瓶中,得产品。
实施例2
按实施例1制备方法制备水凝胶面膜,不同的是按如下重量百分比配制水凝胶面膜:
一种温敏型水凝胶面膜,以重量百分比计,组分如下:壳聚糖1%、透明质酸2%、可溶性丝素蛋白2%、尿囊素0.02%、乳酸0.2%、甘油0.6%、丙二醇1%、表皮生长因子0.001%、羟苯甲酯0.01%,余量为水;
实施例3
按实施例1制备方法制备水凝胶面膜,不同的是按如下重量百分比配制水凝胶面膜:壳聚糖5%、透明质酸0.5%、可溶性丝素蛋白0.5%、尿囊素0.02%、乳酸0.2%、甘油0.6%、丙二醇1%、表皮生长因子0.001%、羟苯甲酯0.01%,余量为水;
实施例4
按实施例1制备方法制备水凝胶面膜,不同的是按如下重量百分比配制水凝胶面膜:一种温敏型水凝胶面膜,以重量百分比计,组分如下:壳聚糖2%、透明质酸1%、尿囊素0.02%、乳酸0.2%、甘油0.6%、丙二醇1%、表皮生长因子0.001%、羟苯甲酯0.01%,余量为水;
实施例5
按实施例1制备方法制备水凝胶面膜,不同的是按如下重量百分比配制水凝胶面膜:壳聚糖2%、可溶性丝素蛋白1%、尿囊素0.02%、乳酸0.2%、甘油0.6%、丙二醇1%、表皮生长因子0.001%、羟苯甲酯0.01%,余量为水;
实施例6
按实施例1制备方法制备水凝胶面膜,不同的是按如下重量百分比配制水凝胶面膜:一种温敏型水凝胶面膜,以重量百分比计,组分如下:壳聚糖5%、透明质酸1%、可溶性丝素蛋白1%、尿囊素0.02%、乳酸0.2%、甘油0.6%、丙二醇1%、表皮生长因子0.001%、羟苯甲酯0.01%,余量为水;
实施例7
按实施例1制备方法制备水凝胶面膜,不同的是按如下重量百分比配制水凝胶面膜:一种温敏型水凝胶面膜,以重量百分比计,组分如下:壳聚糖5%、可溶性丝素蛋白1%、尿囊素0.02%、乳酸0.2%、甘油0.6%、丙二醇1%、表皮生长因子0.001%、羟苯甲酯0.01%,余量为水;
实施例8
按实施例1制备方法制备水凝胶面膜,不同的是按如下重量百分比配制水凝胶面膜:一种温敏型水凝胶面膜,以重量百分比计,组分如下:壳聚糖2%、透明质酸1%、可溶性丝素蛋白1%、乳酸0.2%、甘油0.6%、丙二醇1%、表皮生长因子0.001%、羟苯甲酯0.01%,余量为水;
实施例9
按实施例1制备方法制备水凝胶面膜,不同的是按如下重量百分比配制水凝胶面膜:一种温敏型水凝胶面膜,以重量百分比计,组分如下:壳聚糖2%、透明质酸1%、可溶性丝素蛋白1%、尿囊素0.02%、乳酸0.2%、甘油0.6%、表皮生长因子0.001%、羟苯甲酯0.01%,余量为水;
实施例10
按实施例1制备方法制备水凝胶面膜,不同的是按如下重量百分比配制水凝胶面膜:一种温敏型水凝胶面膜,以重量百分比计,组分如下:壳聚糖2%、透明质酸1%、可溶性丝素蛋白1%、尿囊素0.02%、乳酸0.2%、甘油0.6%、丙二醇0.5%、表皮生长因子0.001%、羟苯甲酯0.01%,余量为水;
凝胶固化温度试验测试:
分别取实施例1-10中水凝胶面膜溶液6mL,平均分为6份,置于试管中,将试管置于10℃、20℃、25℃、30℃、35℃、40℃的水浴条件下,观察其胶凝情况,结果见下表:
由上表可以看出,实施例1-3,8-10均可形成稳定的凝胶状物质,而实施例4-7不能形成稳定的水凝胶,由此可见,壳聚糖、透明质酸和可溶性丝素蛋白的组合对于凝胶的形成起到了至关重要的作用,缺少任何一个组分,均不能形成凝胶状物;
活性物质的吸收检测:
取大鼠背部皮肤(剪切至相同面积),将其放入Franze扩散池中,32℃水浴加热,将实施例1-10的水凝胶面膜等量的喷涂于皮肤上方(距离皮肤10厘米,喷涂10次),进行扩散实验,30分钟后取样检测表皮生长因子的累计透过量,结果如下:
累计透过量(μg/cm2) | |
实施例1 | 201 |
实施例2 | 198 |
实施例3 | 199 |
实施例4 | 110 |
实施例5 | 121 |
实施例6 | 101 |
实施例7 | 99 |
实施例8 | 96 |
实施例9 | 100 |
实施例10 | 156 |
由此可见,实施例1-3均具有较强的透皮吸收的效果,而未形成凝胶的实施例4-7透皮吸收效果较差,实施例8-9与实施例1相比,分别减少了尿囊素和丙二醇,而透皮吸收效果明显下降,实施例10减少了丙二醇的用量,透皮吸收较实施例1降低,由此可见,尿囊素和丙二醇联合使用对表皮生长因子的透皮吸收是有意义的。
本发明的水凝胶面膜,通过喷涂的方式施用,通过皮肤表面的温度,迅速形成凝胶,有利于水分的保持,同时,凝胶的形成也有利于活性成分的透皮吸收,尿囊素和丙二醇的联合应用对于活性成分的吸收也具有重要意义。
Claims (9)
1.一种温敏型水凝胶面膜,其特征在于包含如下组分:凝胶基质、乳酸、尿囊素、保湿剂、防腐剂、生物活性分子。
2.如权利要求1所述的温敏型水凝胶面膜,其特征在于,凝胶基质包含温敏型凝胶材料,选自壳聚糖、透明质酸、可溶性丝素蛋白、羟丙甲基纤维素、聚乙烯醇中的一种或组合。
3.如权利要求1所述的水凝胶面膜,其特征在于,保湿剂选自甘油、丙二醇、山梨醇中的一种或组合。
4.如权利要求1所述的水凝胶面膜,其特征在于,防腐剂选自羟苯甲酯、羟苯丙酯中的一种或两种组合。
5.如权利要求1所述的水凝胶面膜,其特征在于,生物活性分子选自表皮生长因子、北美金缕梅提取物、酵母提取物、抗坏血酸、茶多酚中的一种或组合。
6.如权利要求1所述的水凝胶面膜,其特征在于,包含如下组分:壳聚糖、透明质酸、可溶性丝素蛋白、尿囊素、乳酸、甘油、丙二醇、表皮生长因子、羟苯甲酯,余量为水。
7.如权利要求1所述的温敏型水凝胶面膜,其特征在于,以重量百分比计,包含如下组分:壳聚糖1-5%、透明质酸0.5-2%、可溶性丝素蛋白0.5-2%、尿囊素0.01-0.02%、乳酸0.1-0.2%、甘油0.3-0.6%、丙二醇0.5-1%、表皮生长因子0-0.001%、羟苯甲酯0-0.01%,余量为水。
8.如权利要求1所述的温敏型水凝胶面膜,其特征在于,以重量百分比计,包含如下组分:壳聚糖2%、透明质酸1%、可溶性丝素蛋白1%、尿囊素0.02%、乳酸0.2%、甘油0.6%、丙二醇1%、表皮生长因子0.001%、羟苯甲酯0.01%,余量为水。
9.一种温敏型水凝胶面膜的制备方法,其特征在于,包含如下步骤:将乳酸溶于水,配制2%的乳酸溶液,加入壳聚糖,加热至50℃,搅拌溶解;依次加入尿囊素、甘油、丙二醇,冷却至20℃以下,得混合溶液A;将透明质酸、可溶性丝素蛋白、表皮生长因子、羟苯甲酯溶于剩余水中,加热至50℃,搅拌,使完全溶解,冷却至20℃以下,得混合溶液B;将溶液B缓慢加入到溶液A中,搅拌,高速剪切,使混合均匀,得水凝胶面膜溶液;将水凝胶面膜溶液填充到喷雾瓶中,得产品。
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