CN108472246A - 用于在药物中使用的胶体颗粒 - Google Patents

用于在药物中使用的胶体颗粒 Download PDF

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Publication number
CN108472246A
CN108472246A CN201680073237.XA CN201680073237A CN108472246A CN 108472246 A CN108472246 A CN 108472246A CN 201680073237 A CN201680073237 A CN 201680073237A CN 108472246 A CN108472246 A CN 108472246A
Authority
CN
China
Prior art keywords
composition
composition according
amphipathic lipids
dspe
colloidal solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680073237.XA
Other languages
English (en)
Chinese (zh)
Inventor
威廉·亨利
理查德·沃尔夫-加拉韦
约翰·梅奥
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cantab Biopharmaceuticals Patents Ltd
Original Assignee
Cantab Biopharmaceuticals Patents Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cantab Biopharmaceuticals Patents Ltd filed Critical Cantab Biopharmaceuticals Patents Ltd
Publication of CN108472246A publication Critical patent/CN108472246A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680073237.XA 2015-10-14 2016-10-14 用于在药物中使用的胶体颗粒 Pending CN108472246A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1518172.0A GB201518172D0 (en) 2015-10-14 2015-10-14 Colloidal particles for use in medicine
GB1518172.0 2015-10-14
PCT/EP2016/074759 WO2017064276A1 (en) 2015-10-14 2016-10-14 Colloidal particles for use in medicine

Publications (1)

Publication Number Publication Date
CN108472246A true CN108472246A (zh) 2018-08-31

Family

ID=55131025

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680073237.XA Pending CN108472246A (zh) 2015-10-14 2016-10-14 用于在药物中使用的胶体颗粒

Country Status (15)

Country Link
US (3) US20190192664A1 (enExample)
EP (1) EP3362039A1 (enExample)
JP (1) JP7160678B2 (enExample)
KR (1) KR20180067616A (enExample)
CN (1) CN108472246A (enExample)
AU (1) AU2016336929B2 (enExample)
BR (1) BR112018007399A2 (enExample)
CA (1) CA3036111C (enExample)
EA (1) EA201890703A1 (enExample)
GB (1) GB201518172D0 (enExample)
HK (1) HK1256814A1 (enExample)
IL (1) IL258567B2 (enExample)
MX (1) MX391574B (enExample)
SG (2) SG10202010711UA (enExample)
WO (1) WO2017064276A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115190883A (zh) * 2019-11-07 2022-10-14 伊利诺伊大学评议会 治疗脓毒症、动脉粥样硬化、血栓形成、中风、心脏病发作和炎症的肽和方法
GB202111759D0 (en) * 2021-08-17 2021-09-29 Cantab Biopharmaceuticals Patents Ltd Modified colloidal particles
GB202111758D0 (en) * 2021-08-17 2021-09-29 Cantab Biopharmaceuticals Patents Ltd Modified colloidal particles for use in the treatment of haemophilia A
GB202111757D0 (en) * 2021-08-17 2021-09-29 Cantab Biopharmaceuticals Patents Ltd Modified colloidal particles for use in the treatment of haemophilia A

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030232075A1 (en) * 2002-05-06 2003-12-18 University Of Minnesota, A Minnesota Corporation Compositions for producing factor Xa
CN1774281A (zh) * 2003-04-15 2006-05-17 奥珀百思控股公司 包含蛋白质和/或多肽以及胶体颗粒的药物组合物
US20070141135A1 (en) * 2005-06-29 2007-06-21 Balu-Lyer Sathy V Compositions and methods for less immunogenic protein-lipid complexes
WO2014136086A1 (en) * 2013-03-08 2014-09-12 Novartis Ag Lipids and lipid compositions for the delivery of active agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
WO1995004524A1 (en) 1993-08-06 1995-02-16 Opperbas Holding B.V. A method for high loading of vesicles with biopolymeric substances
ATE283034T1 (de) 1998-04-27 2004-12-15 Opperbas Holding Bv Pharmazeutische zusammensetzungen enthaltend faktor viii und neutrale liposomen
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
HUP0202177A3 (en) 1999-07-14 2004-05-28 Alza Corp Mountain View Neutral lipopolymer and liposomal compositions containing same
CN102639113A (zh) 2009-06-03 2012-08-15 J·C·梅奥 用于治疗深部组织疼痛的制剂
KR20120129864A (ko) 2009-08-21 2012-11-28 타겟티드 딜리버리 테크놀러지스 리미티드 소포성 제형
GB201007356D0 (en) 2010-04-30 2010-06-16 Leverton Licence Holdings Ltd Conjugated factor VIIa
GB201007357D0 (en) 2010-04-30 2010-06-16 Leverton Licence Holdings Ltd Conjugated factor VIII
AP2014008049A0 (en) 2012-04-16 2014-11-30 Cantab Biopharmaceuticals Patents Ltd Optimised subcuraneous therapeutic agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030232075A1 (en) * 2002-05-06 2003-12-18 University Of Minnesota, A Minnesota Corporation Compositions for producing factor Xa
CN1774281A (zh) * 2003-04-15 2006-05-17 奥珀百思控股公司 包含蛋白质和/或多肽以及胶体颗粒的药物组合物
US20070141135A1 (en) * 2005-06-29 2007-06-21 Balu-Lyer Sathy V Compositions and methods for less immunogenic protein-lipid complexes
WO2014136086A1 (en) * 2013-03-08 2014-09-12 Novartis Ag Lipids and lipid compositions for the delivery of active agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AARON PENG ET AL.: "PEGylation of a Factor VIII–Phosphatidylinositol Complex: Pharmacokinetics and Immunogenicity in Hemophilia A Mice", 《THE AAPS JOURNAL》 *

Also Published As

Publication number Publication date
JP7160678B2 (ja) 2022-10-25
AU2016336929A1 (en) 2018-05-10
EP3362039A1 (en) 2018-08-22
US20250170244A1 (en) 2025-05-29
CA3036111A1 (en) 2017-04-20
US20210093721A1 (en) 2021-04-01
IL258567B2 (en) 2025-08-01
GB201518172D0 (en) 2015-11-25
IL258567A (en) 2018-05-31
SG10202010711UA (en) 2020-12-30
JP2018535952A (ja) 2018-12-06
AU2016336929B2 (en) 2022-09-29
BR112018007399A2 (pt) 2018-10-16
WO2017064276A1 (en) 2017-04-20
IL258567B1 (en) 2025-04-01
US20190192664A1 (en) 2019-06-27
EA201890703A1 (ru) 2018-11-30
KR20180067616A (ko) 2018-06-20
HK1256814A1 (zh) 2019-10-04
CA3036111C (en) 2023-06-06
SG11201802956RA (en) 2018-05-30
MX391574B (es) 2025-03-21
MX2018004445A (es) 2018-08-14

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