CN108469520B - Dry-type immunochromatography detector and detection method thereof - Google Patents
Dry-type immunochromatography detector and detection method thereof Download PDFInfo
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- CN108469520B CN108469520B CN201810134327.6A CN201810134327A CN108469520B CN 108469520 B CN108469520 B CN 108469520B CN 201810134327 A CN201810134327 A CN 201810134327A CN 108469520 B CN108469520 B CN 108469520B
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
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- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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Abstract
The invention discloses a dry-type immunochromatography detector, wherein a fluorescence detection mechanism, a storage box for storing a reagent card and a movement mechanism for driving the reagent card to pass through the fluorescence detection mechanism are arranged in a shell; still be equipped with the scanning mechanism who is used for scanning reagent card information in the shell, be used for judging whether the thing box of putting has the judgment mechanism of reagent card, be used for starting fluorescence detection mechanism's on-off mechanism, be used for gathering fluorescence detection mechanism's information acquisition module of information and be used for handling the host system who detects information. The invention completes sample sending and detection work by arranging the fluorescence detection mechanism, the movement mechanism, the scanning mechanism, the judgment mechanism, the switching mechanism, the information acquisition module and the main control module, automatically sends sample in the whole process, and has high efficiency and short time consumption.
Description
Technical Field
The invention relates to the technical field of immunochromatography, in particular to a dry-type immunochromatography detector and a detection method thereof.
Background
The immunochromatography is a rapid diagnosis technology which is started in foreign countries in recent years, and the principle is that a specific antibody is firstly fixed in a certain zone of a nitrocellulose membrane, after one end of the dried nitrocellulose membrane is immersed in a sample, the sample moves forwards along the membrane due to capillary action, when the sample moves to a region where the antibody is fixed, a corresponding antigen in the sample is specifically combined with the antibody, and if the region is dyed by immune colloidal gold or immune enzyme, the region can show a certain color, so that the specific immune diagnosis is realized. However, the existing dry-type immunochromatographic detector adopts a sample adding mode of manually sampling a sample and manually sending the sample to a sample mixing or detection area, and the sample sending mode needs a lot of manpower and material resources, so that the detection process becomes slow, and when a large amount of samples need to be detected, a large amount of time can be wasted, and the detection speed can be seriously influenced.
Disclosure of Invention
The invention aims to provide a dry-type immunochromatography detector and a detection method thereof aiming at the defects in the prior art.
The purpose of the invention is realized by the following technical scheme: a dry immunochromatographic detector comprises a housing; a fluorescence detection mechanism, a storage box for storing the reagent card and a movement mechanism for driving the reagent card to pass through the fluorescence detection mechanism are arranged in the shell;
still be equipped with the scanning mechanism who is used for scanning reagent card information in the shell, be used for judging whether the thing box of putting has the judgment mechanism of reagent card, be used for starting fluorescence detection mechanism's on-off mechanism, be used for gathering fluorescence detection mechanism's information acquisition module of information and be used for handling the host system who detects information.
The invention is further provided that the movement mechanism comprises a base arranged in the shell, a sliding rail arranged on the base, a sliding block used for sliding on the sliding rail, a transmission component used for driving the sliding block to slide on the sliding rail and a motor used for driving the transmission component to work; the motor is arranged on the base; the storage box is arranged on the sliding block.
The invention is further provided that the transmission assembly comprises a conveyor belt and an idler wheel arranged on the base; one end of the conveyor belt is in transmission connection with the motor; the other end of the conveyor belt is in transmission connection with an idler wheel; the transmission assembly also comprises a connecting block linked with the conveying belt; the connecting block is connected with the storage box.
The invention is further provided that the fluorescence detection mechanism comprises a fixed seat arranged in the shell and a fluorescence component arranged on the fixed seat;
the fluorescent component comprises a shell; a first light-emitting assembly, a second light-emitting assembly and a third light-emitting assembly are sequentially arranged in the shell along the moving direction of the reagent card;
the first light-emitting component comprises a first light-emitting piece and a first photodiode used for receiving light rays emitted by the first light-emitting piece;
the second light-emitting component comprises a second light-emitting piece, a first plano-convex lens, a first narrow-band filter, a first lens and a second photodiode; the light emitted by the second light-emitting component passes through the first plano-convex lens, the first narrow-band optical filter and the first lens in sequence and then is received by the second photodiode;
the third light-emitting component comprises a laser module, a second plano-convex lens, a second narrow-band filter, a second lens and a third photodiode; and light rays emitted by the laser module sequentially pass through the second plano-convex lens, the second narrow-band filter and the second lens and are received by the third photodiode.
The invention is further arranged that the first light-emitting element comprises two red LEDs and two blue LEDs; the two red light LEDs and the two blue light LEDs are respectively arranged on the periphery of the first photodiode; the second light-emitting piece comprises four purple light LEDs; the four purple light LEDs are respectively arranged on the periphery of the second photodiode.
The invention is further arranged that the judging mechanism comprises an infrared emitter arranged on one side of the shell and an infrared receiver arranged on the other side of the shell, and the storage box is provided with a through hole for infrared rays to pass through.
The invention is further provided that the switch mechanism comprises a photoelectric sensor arranged at one end of the slide rail and a blocking piece arranged on the surface of the storage box.
The invention is further arranged that the scanning mechanism comprises a bar code scanner arranged in the shell and an information card interface arranged on the surface of the shell; the bar code scanner and the information card interface are electrically connected with the main control module.
The invention is further arranged that the surface of the shell is provided with a touch display screen; a thermal printer is arranged in the shell.
A detection method of a dry-type immunochromatography detector comprises the following steps:
a. the moving mechanism drives the article placing box to move into the detection port of the shell;
b. putting the reagent card with the bar code into a storage box;
c. the judging mechanism starts the moving mechanism after judging that the reagent card is placed in the storage box;
d. the moving mechanism drives the reagent card to move back to the original point;
e. after the switching mechanism detects that the movement mechanism moves back to the original point, the scanning mechanism scans the bar code of the reagent card to obtain the name and the batch number of the reagent card;
f. the moving mechanism drives the reagent card to move to the fluorescence detection mechanism for detection;
g. the information acquisition module acquires information of the fluorescence detection mechanism;
h. the main control module calculates a peak position, a peak value and a peak area through an algorithm;
i. and calculating the concentration value of the item corresponding to the sample.
The invention has the beneficial effects that: the invention completes sample sending and detection work by arranging the fluorescence detection mechanism, the movement mechanism, the scanning mechanism, the judgment mechanism, the switching mechanism, the information acquisition module and the main control module, automatically sends sample in the whole process, and has high efficiency and short time consumption.
Drawings
The invention is further illustrated by means of the attached drawings, but the embodiments in the drawings do not constitute any limitation to the invention, and for a person skilled in the art, other drawings can be derived on the basis of the following drawings without inventive effort.
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic structural view from another perspective of the present invention;
FIG. 3 is a schematic view of the motion mechanism of the present invention;
FIG. 4 is a schematic structural view of another perspective of the motion mechanism of the present invention;
FIG. 5 is a schematic view of the structure of the fluorescence detection mechanism of the present invention;
FIG. 6 is a schematic view of another perspective structure of the fluorescence detection mechanism of the present invention;
FIG. 7 is a cross-sectional view of a phosphor assembly of the present invention;
1-a housing; 11-a fluorescence detection mechanism; 12-a motion mechanism; 13-a master control module; 14-a storage box;
21-a base; 221-a slide rail; 222-a slider; 231-an idler wheel; 232-a conveyor belt; 233-connecting block; 24-a motor;
31-a fixed seat; 33-a housing; 341-first light emitting element; 342-a first photodiode; 351-a second light emitting member; 352-first plano-convex lens; 353-a first narrow band filter; 354-first lens; 355-a second photodiode; 361-laser module; 362-second plano-convex lens; 363-a second narrow band filter; 364-a second lens; 365-a third photodiode;
41-an infrared emitter; 42-an infrared receiver; 43-a through hole;
51-a photosensor; 52-a baffle plate;
61-barcode scanner; 62-information card interface; 63-touch control display screen; 64-thermal printer.
Detailed Description
The invention is further described with reference to the following examples.
As can be seen from fig. 1 to 7; the dry immunochromatographic detector of the present embodiment includes a housing 1; a fluorescence detection mechanism 11, an object placing box 14 for placing a reagent card and a movement mechanism 12 for driving the reagent card to pass through the fluorescence detection mechanism 11 are arranged in the shell 1;
the shell 1 is also internally provided with a scanning mechanism for scanning reagent card information, a judging mechanism for judging whether the storage box 14 has a reagent card, a switch mechanism for starting the fluorescence detection mechanism 11, an information acquisition module for acquiring the information of the fluorescence detection mechanism 11 and a main control module 13 for processing detection information.
Specifically, in the dry immunochromatographic assay detector of this embodiment, when detecting a reagent card, the moving mechanism 12 drives the storage box 14 to move to the detection port of the housing 1, then the reagent card with a barcode is placed in the storage box 14, when the judgment mechanism judges that the storage box 14 has the reagent card placed therein, the moving mechanism 12 is started to drive the reagent card to move back to the original point, the switching mechanism detects that the moving mechanism 12 moves back to the original point, the scanning mechanism scans the barcode of the reagent card to obtain the name and lot number of the reagent card, then the moving mechanism 12 drives the reagent card to move to the fluorescence detection mechanism 11 for detection, and the information acquisition module acquires information of the fluorescence detection mechanism 11; the main control module 13 calculates the peak position, the peak value and the peak area through an algorithm to finally calculate the concentration value of the item corresponding to the sample. In the embodiment, the fluorescence detection mechanism 11, the movement mechanism 12, the scanning mechanism, the judgment mechanism, the switch mechanism, the information acquisition module and the main control module 13 are arranged to complete sample sending and detection, the sample is automatically sent in the whole process, the efficiency is high, and the consumed time is short.
In the dry immunochromatographic detector of this embodiment, the movement mechanism 12 includes a base 21 disposed in the housing 1, a slide rail 221 disposed on the base 21, a slider 222 configured to slide on the slide rail 221, a transmission assembly configured to drive the slider 222 to slide on the slide rail 221, and a motor 24 configured to drive the transmission assembly to operate; the motor 24 is arranged on the base 21; the storage box 14 is arranged on the sliding block 222. In the dry immunochromatographic assay of this embodiment, the transmission assembly includes a transmission belt 232 and an idler wheel 231 disposed on the base 21; one end of the conveyor belt 232 is in transmission connection with the motor 24; the other end of the conveyor belt 232 is in transmission connection with an idler wheel 231; the transmission assembly further comprises a connecting block 233 which is linked with the conveying belt 232; the connecting block 233 is connected with the storage box 14.
Specifically, after putting into the reagent card and putting into the thing box 14, control motor 24 starts, motor 24 and idler 231 drive conveyer belt 232 motion jointly, thereby drive connecting block 233 motion, so that slider 222 slides on slide rail 221, thereby make slider 222 make reciprocating motion on slide rail 221 through the positive and negative rotation of motor 24, can control slider 222 through motor 24 and drive assembly and slide on slide rail 221 and send the reagent card to appointed region, accomplish the work of sending a sample, whole automatic sample sending, it is efficient to send a sample, and consuming time is short.
In the dry immunochromatographic detection instrument of this embodiment, the fluorescence detection mechanism 11 includes a fixing seat 31 disposed in the housing 1 and a fluorescence component disposed on the fixing seat 31;
the fluorescent assembly includes a housing 33; a first light-emitting assembly, a second light-emitting assembly and a third light-emitting assembly are sequentially arranged in the shell 33 along the moving direction of the reagent card;
the first light emitting assembly includes a first light emitting element 341 and a first photodiode 342 for receiving light emitted from the first light emitting element 341;
the second light emitting assembly includes a second light emitting element 351, a first plano-convex lens 352, a first narrow band filter 353, a first lens 354 and a second photodiode 355; the light emitted by the second light emitting element 351 passes through the first plano-convex lens 352, the first narrow band filter 353 and the first lens 354 in sequence and is received by the second photodiode 355;
the third light emitting assembly comprises a laser module 361, a second plano-convex lens 362, a second narrow band filter 363, a second lens 364 and a third photodiode 365; the light emitted by the laser module 361 passes through the second plano-convex lens 362, the second narrowband filter 363 and the second lens 364 in sequence and is received by the third photodiode 365.
Specifically, when detecting, place the reagent card that has the sample on putting thing box 14, slider 222 drives the reagent card and passes through first light-emitting component, second light-emitting component and third light-emitting component along slide rail 221 in proper order, measure the sample of reagent card with first light-emitting component 341, second light-emitting component 351 and radium-shine module 361 respectively, obtain accurate data after measuring many times through the light source of difference, in addition, can further strengthen measuring effect through setting up plano-convex lens, narrowband optical filter, and lens.
In the dry immunochromatographic assay of this embodiment, the first light-emitting member 341 includes two red LEDs and two blue LEDs; the two red LEDs and the two blue LEDs are respectively disposed around the first photodiode 342; the second light emitting member 351 includes four violet LEDs; the four violet LEDs are respectively disposed around the second photodiode 355.
Specifically, the present embodiment employs a plurality of light beams with different spectral ranges for detection, which can have the best excitation effect for most fluorescent substances, so that the measurement is more accurate.
In the dry immunochromatographic assay of this embodiment, the determination mechanism includes an infrared emitter 41 disposed on one side of the housing 1 and an infrared receiver 42 disposed on the other side of the housing 1, and the storage box 14 is provided with a through hole 43 for infrared rays to pass through. Through setting up infrared receiver 42 and infrared emitter 41, can judge whether place the reagent card in putting the thing box 14 to the starter motor 24 work realizes automaticly.
In the dry immunochromatographic detector of this embodiment, the switch mechanism includes a photoelectric sensor 51 disposed at one end of the slide rail 221 and a blocking piece 52 disposed on the surface of the storage box 14. Through setting up photoelectric sensor 51, when putting thing box 14 and sliding to the original point, separation blade 52 shelters from photoelectric sensor 51, starts the fluorescence subassembly this moment, realizes automaticly.
In the dry immunochromatographic detector of this embodiment, the scanning mechanism includes a barcode scanner 61 disposed in the housing 1 and an information card interface 62 disposed on the surface of the housing 1; the bar code scanner 61 and the information card interface 62 are electrically connected to the main control module 13. When in use, an information card loaded with model information of various reagent cards can be put into the information card interface 62, so that the main control module 13 can compare the data of the information card with the data scanned by the bar code scanner 61.
In the dry immunochromatographic detector of this embodiment, a touch display screen 63 is disposed on the surface of the housing 1; a thermal printer 64 is provided in the housing 1. The above arrangement facilitates user operation.
In addition, the main control module 13 of this embodiment adopts secondary control, and the middle is communicated through RS 232. The A8 core board mainly performs data calculation, processing, print job and interface control, display drive control, information card reading, and the like. The secondary MCU mainly completes the control of the motor 24, the control of the bar code scanner 61, the control of the origin photoelectric switch, the control of the signal acquisition module and the control of the judgment mechanism.
A detection method of a dry-type immunochromatography detector comprises the following steps:
a. the moving mechanism 12 drives the storage box 14 to move into the detection port of the shell 1;
b. placing the reagent card with the bar code into the storage box 14;
c. the judging mechanism starts the moving mechanism 12 after judging that the reagent card is placed in the placing box 14;
d. the moving mechanism 12 drives the reagent card to move back to the original point;
e. after the switching mechanism detects that the moving mechanism 12 moves back to the original point, the scanning mechanism scans the bar code of the reagent card to obtain the name and the batch number of the reagent card;
f. the moving mechanism 12 drives the reagent card to move to the fluorescence detection mechanism 11 for detection;
g. the information acquisition module acquires information of the fluorescence detection mechanism 11;
h. the main control module 13 calculates a peak position, a peak value and a peak area through an algorithm;
i. and calculating the concentration value of the item corresponding to the sample.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (5)
1. A dry immunochromatography detector is characterized in that: comprising a housing (1); a fluorescence detection mechanism (11), an object placing box (14) for placing a reagent card and a movement mechanism (12) for driving the reagent card to pass through the fluorescence detection mechanism (11) are arranged in the shell (1);
the shell (1) is also internally provided with a scanning mechanism for scanning reagent card information, a judging mechanism for judging whether the storage box (14) has a reagent card, a switch mechanism for starting the fluorescence detection mechanism (11), an information acquisition module for acquiring the information of the fluorescence detection mechanism (11) and a main control module (13) for processing detection information;
the movement mechanism (12) comprises a base (21) arranged in the shell (1), a sliding rail (221) arranged on the base (21), a sliding block (222) used for sliding on the sliding rail (221), a transmission assembly used for driving the sliding block (222) to slide on the sliding rail (221), and a motor (24) used for driving the transmission assembly to work; the motor (24) is arranged on the base (21); the storage box (14) is arranged on the sliding block (222);
the fluorescence detection mechanism (11) comprises a fixed seat (31) arranged in the shell (1) and a fluorescence component arranged on the fixed seat (31);
the fluorescent assembly comprises a shell (33); a first light-emitting component, a second light-emitting component and a third light-emitting component are sequentially arranged in the shell (33) along the moving direction of the reagent card;
the first light-emitting component comprises a first light-emitting piece (341) and a first photodiode (342) for receiving light emitted by the first light-emitting piece (341);
the second light-emitting component comprises a second light-emitting piece (351), a first plano-convex lens (352), a first narrow-band filter (353), a first lens (354) and a second photodiode (355); the light emitted by the second light-emitting piece (351) passes through the first plano-convex lens (352), the first narrow-band filter (353) and the first lens (354) in sequence and then is received by the second photodiode (355);
the third light-emitting component comprises a laser module (361), a second plano-convex lens (362), a second narrow-band filter (363), a second lens (364) and a third photodiode (365); the light emitted by the laser module (361) passes through a second plano-convex lens (362), a second narrow-band filter (363) and a second lens (364) in sequence and then is received by a third photodiode (365);
the first light-emitting component (341) comprises two red LEDs and two blue LEDs; the two red light LEDs and the two blue light LEDs are respectively arranged on the periphery of the first photodiode (342); the second light emitting member (351) comprises four purple light LEDs; the four purple light LEDs are respectively arranged on the periphery of the second photodiode (355);
the scanning mechanism comprises a bar code scanner (61) arranged in the shell (1) and an information card interface (62) arranged on the surface of the shell (1); the bar code scanner (61) and the information card interface (62) are electrically connected with the main control module (13);
the switch mechanism comprises a photoelectric sensor (51) arranged at one end of the sliding rail (221) and a blocking piece (52) arranged on the surface of the storage box (14).
2. The dry immunochromatographic detector according to claim 1, wherein: the transmission assembly comprises a conveyor belt (232) and an idler pulley (231) arranged on the base (21); one end of the conveyor belt (232) is in transmission connection with the motor (24); the other end of the conveyor belt (232) is in transmission connection with an idler wheel (231); the transmission component also comprises a connecting block (233) which is linked with the conveyor belt (232); the connecting block (233) is connected with the storage box (14).
3. The dry immunochromatographic detector according to claim 1, wherein: the judging mechanism comprises an infrared emitter (41) arranged on one side of the shell (1) and an infrared receiver (42) arranged on the other side of the shell (1), and the storage box (14) is provided with a through hole (43) for infrared rays to pass through.
4. The dry immunochromatographic detector according to claim 1, wherein: a touch display screen (63) is arranged on the surface of the shell (1); a thermal printer (64) is arranged in the shell (1).
5. A method of testing a dry immunochromatographic test device according to claim 1, comprising the steps of:
a. the moving mechanism (12) drives the storage box (14) to move into the detection port of the shell (1);
b. putting the reagent card with the bar code into a storage box (14);
c. the judging mechanism starts the moving mechanism (12) after judging that the reagent card is placed in the placing box (14);
d. the moving mechanism (12) drives the reagent card to move back to the original point;
e. after the switching mechanism detects that the moving mechanism (12) moves back to the original point, the scanning mechanism scans the bar code of the reagent card to obtain the name and the batch number of the reagent card;
f. the moving mechanism (12) drives the reagent card to move to the fluorescence detection mechanism (11) for detection;
g. the information acquisition module acquires information of the fluorescence detection mechanism (11);
h. the main control module (13) calculates the peak position, the peak value and the peak area through an algorithm;
i. and calculating the concentration value of the item corresponding to the sample.
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| CN112540170B (en) * | 2019-09-20 | 2022-08-05 | 深圳迎凯生物科技有限公司 | Immunoassay analyzer and analysis method |
| CN111474360B (en) * | 2020-05-18 | 2023-10-10 | 四川新健康成生物股份有限公司 | Dry-type fluorescence immunoassay appearance |
| CN112748245A (en) * | 2020-12-30 | 2021-05-04 | 浙江省智能诊疗设备制造业创新中心 | Multi-channel fluorescence immunochromatography quantitative detector and detection method thereof |
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