CN108434201A - Treat the Chinese medicine composition and preparation method thereof of lumbocrural pain - Google Patents
Treat the Chinese medicine composition and preparation method thereof of lumbocrural pain Download PDFInfo
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
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Abstract
The present invention relates to a kind of Chinese medicine composition and preparation method thereof for treating lumbocrural pain, the Chinese medicine composition of the treatment lumbocrural pain is prepared by following raw materials：Radix Angelicae Sinensis, Herba Lycopi, akebi, cassia twig.The present invention treats the Chinese medicine composition of lumbocrural pain, chooses natural traditional Chinese medicine scientific compatibility, and formula is simple, each bulk pharmaceutical chemicals synergistic effect plays promote breath and open depression, promoting blood circulation and stopping pain, expelling wind and eliminating dampness, the effect of eliminating cold to stop pain, quick, treating both manifestation and root cause of disease has no toxic side effect, and preparation method is simple, convenient to take, at low cost, cure rate is high.
Description
Technical field
The present invention relates to a kind of Chinese medicines, specifically, being related to a kind of Chinese medicine composition that treating lumbocrural pain and its preparation
Method.
Background technology
Lumbocrural pain refers to lumbago, buttocks pain, skelagia, the aching and limp numbness of legs and feet etc., is a kind of clinically very common disease
Shape, incidence are only second to catch a cold, and are even more to be related to orthopaedics, massage section and department of acupuncture and moxibustion about its treatment.Induce lumbocrural pain
The possible cause of disease has：Lesion tissue by bone, joint and soft tissue lesions, especially backbone and ridge, such as acute lumbar muscle sprain, lumber ertebral disc
Herniation, waist chronic strain and lumbar vertebrae congenital abnormality etc.；It is also possible that the referred pain and vertebra by viscera disease are anxious
Chronic inflammation and pain caused by tumour, such as kidney trouble, chronic pancreatitis, diabetes, coronary heart disease and vertebra；It is also possible to
Caused by being psychiatric disease, such as depression.
At present to there are some following in the treatment of lumbocrural pain and diagnosis, it is treatment to disease first and examines
Disconnected to think little of, this is for patient and doctor are common.Because the course of disease of the disease is slow, general people are less heavy
Do not have pain to being all not very willing to see a doctor when influencing Working Life depending on, most of people, so as to cause the state of an illness delay and control
Therapeutic effect it is bad, some even can be difficult to cure, and cause lifelong pain.Also some situations are exactly, some doctors in face of
Take exception to when patient assessment, it is believed that it is that disease is inessential to be diagnosed to be, and can finally pass through operative treatment；Followed by it treats
Method is lack of standardization, and when in face of different doctors, either Different hospital is medical, some are said to perform the operation such as same patient, have
A bit we were telling you not having to, some theory will take medicine, and have we were telling you take medicine it is useless, such that patient does not know how to cope with the disease of oneself
Feelings；Also it is exactly treatment thoughts extramalization, the thinking that the doctor also having can have treatment thoughts extramalization in arms goes to treat the disease of patient
Feelings, the doctor specially to perform an operation will be considered that this is performed an operation, not perform an operation and have no other way, and encounter the doctor for being bad to perform an operation,
It can then say that operation risk is big, effect is bad, may also have sequelae, and patient can be advised to carry out expectant treatment.These situations pair
It is not best in patient, is delayed conditions of patients sometimes.
Lumbocrural pain is constantly accelerated in social economy's rapid development, people's Working Life rhythm, is increasingly becoming a kind of common
In the case of disease, even there is lumbocrural pain section in the also attention for increasingly causing people slowly, some institutes of traditional Chinese medicine.When
So, lumbocrural pain has become one of the main problem in order to perplex modern life, so can effectively be controlled with regard to how to develop one kind
The Chinese medicine composition for treating lumbocrural pain is one and needs the research constantly explored.
Invention content
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine compositions and preparation method thereof for treating lumbocrural pain.
The present invention is achieved through the following technical solutions：
A kind of Chinese medicine composition for treating lumbocrural pain, is prepared by following raw materials：Radix Angelicae Sinensis, Herba Lycopi, akebi, cassia twig.
Preferably, a kind of Chinese medicine composition for treating lumbocrural pain, is prepared by the raw material of following weight parts：Radix Angelicae Sinensis
20-40 parts, 20-40 parts of Herba Lycopi, 20-40 parts of akebi, 20-40 parts of cassia twig.
The preparation method of the Chinese medicine composition for the treatment of lumbocrural pain of the present invention, includes the following steps：
(1) each raw material is weighed by weight ratio；
(2) Radix Angelicae Sinensis, Herba Lycopi, akebi, cassia twig are uniformly mixed to obtain the final product.
Preferably, the preparation method of the Chinese medicine composition of the treatment lumbocrural pain, includes the following steps：
(1) each raw material is weighed by weight ratio；
(2) Radix Angelicae Sinensis, Herba Lycopi, akebi, cassia twig be crushed into 20-50 mesh sieve respectively, is uniformly mixed, obtains Chinese medicine coarse powder；
(3) Chinese medicine coarse powder, auxiliary agent are added in ball mill and carry out ball milling, the Chinese medicine composition for the lumbocrural pain that obtains medical treatment.
The Chinese medicine coarse powder, auxiliary agent mass ratio be 10：(0.01-0.03).
The auxiliary agent is beta-cyclodextrin.
Preferably, the auxiliary agent is functionalization beta-cyclodextrin.
The functionalization beta-cyclodextrin is prepared by following methods：By beta-cyclodextrin, lauric monoglyceride, sucrose dodecane
Acid esters is 1 in mass ratio：(0.03-0.06)：(0.01-0.05) is uniformly mixed, and be crushed 80-120 mesh sieve, is obtained mixture；
The water for adding mixture into mixture weight 10-30% is uniformly mixed, and twin (double) screw extruder is then added and is squeezed, first segment
Temperature is 40-60 DEG C, and second segment temperature is 70-90 DEG C, and third section temperature is 110-140 DEG C, rotating speed 100-200r/min, into
Doses is 2-4kg/h, and obtained material crushed 30-80 mesh in 50-60 DEG C of dry 1-3h, then by obtained material after drying after extruding
Sieve to get.
Preferably, the functionalization beta-cyclodextrin is prepared by following methods：By beta-cyclodextrin, lauric monoglyceride, sugarcane
Sugared dodecylate, phytosterin ester are 1 in mass ratio：(0.03-0.06)：(0.01-0.05)：(0.005-0.02) mixing is equal
It is even, 80-120 mesh sieve is crushed, mixture is obtained；The water for adding mixture into mixture weight 10-30% is uniformly mixed, then
Twin (double) screw extruder is added to be squeezed, first segment temperature is 40-60 DEG C, and second segment temperature is 70-90 DEG C, and third section temperature is
110-140 DEG C, rotating speed 100-200r/min, inlet amount 2-4kg/h, after extruding obtained material in 50-60 DEG C of dry 1-3h,
Again by obtained material after drying crushed 30-80 mesh sieve to get.
The phytosterin ester is gallic acid phytosterin ester and/or phytosterol cinnamate.Preferably, described
Phytosterin ester is made of 65-75wt% gallic acids phytosterin ester and 25-35wt% phytosterol cinnamates.
The rotating speed of the ball mill is 150-250r/min, Ball-milling Time 40-80min.
The application method of the Chinese medicine composition of above-mentioned treatment lumbocrural pain：Be decocted in water for oral dose 2 times/day or or with drug it is acceptable
Carrier mix and according to galenic pharmacy routine techniques Chinese medicine preparation be made.
Compared with prior art, the present invention has the advantages that following prominent and effect：
The present invention treats the Chinese medicine composition of lumbocrural pain, chooses natural traditional Chinese medicine scientific compatibility, formula is simple, each bulk pharmaceutical chemicals
Synergistic effect plays promote breath and open depression, promoting blood circulation and stopping pain, expelling wind and eliminating dampness, the effect of eliminating cold to stop pain, quick, treating both manifestation and root cause of disease, nontoxic pair
Effect, and preparation method is simple, and convenient to take, at low cost, cure rate is high.
Specific implementation mode
Below by specific implementation mode, the present invention is further described.
Radix Angelicae Sinensis in embodiment is provided, source area Gansu by Bozhou Bai Chuan pharmaceutcal corporation, Ltds.
Herba Lycopi in embodiment is provided, source area Sichuan by Hong Tai prepared slices of Chinese crude drugs Co., Ltd of Minyue County.
Akebi in embodiment is provided, source area Jiangsu by Hong Tai prepared slices of Chinese crude drugs Co., Ltd of Minyue County.
Cassia twig in embodiment is provided, source area Yunnan by Xichou County Xiang Guang medicinal materials Co., Ltd.
Gallic acid phytosterin ester in the Chinese patent application No. is 201510051931.9 according to implementing in embodiment
Prepared by method shown in example 1, embodiment 2 and embodiment 5 (first synthesizes triacetyl gallic acid, then according to reality according to embodiment 1
It applies example 2 and triacetyl gallic acid phytosterin ester is synthesized by triacetyl gallic acid, do not eaten by triacetyl according to embodiment 5 finally
Sub- acid phytosterin ester synthesizing gallic acid phytosterin ester).
Lauric monoglyceride in embodiment, i.e. glyceryl laurate ester, No. CAS：142-18-7.
Beta-cyclodextrin is provided by one dream bio tech ltd of Zhejiang in embodiment, and rank is food-grade.
Sucrose dodecanoate in embodiment, No. CAS：25339-99-5.
Ball mill is the PBM-2 that crystallization work Machinery Co., Ltd. provides in Changsha in embodiment, and structure type is planetary.
Phytosterol cinnamate is according to embodiment in the Chinese patent application No. is 201310412305.9 1 in embodiment
It is prepared by shown method.
Embodiment 1
The Chinese medicine composition for treating lumbocrural pain, is prepared by the raw material of following weight parts：30 parts of Radix Angelicae Sinensis, Herba Lycopi 30
Part, 30 parts of akebi, 30 parts of cassia twig.
The preparation method of the Chinese medicine composition of the treatment lumbocrural pain, includes the following steps：
(1) each raw material is weighed by weight ratio；
(2) Radix Angelicae Sinensis, Herba Lycopi, akebi, cassia twig are uniformly mixed to obtain the final product.
Embodiment 2
The Chinese medicine composition for treating lumbocrural pain, is prepared by the raw material of following weight parts：30 parts of Radix Angelicae Sinensis, Herba Lycopi 30
Part, 30 parts of akebi, 30 parts of cassia twig.
The preparation method of the Chinese medicine composition of the treatment lumbocrural pain, includes the following steps：
(1) each raw material is weighed by weight ratio；
(2) Radix Angelicae Sinensis, Herba Lycopi, akebi, cassia twig be crushed into 40 mesh sieve respectively, is uniformly mixed, obtains Chinese medicine coarse powder；
(3) it is 10 in mass ratio by Chinese medicine coarse powder, auxiliary agent：0.02 after mixing be added ball mill in carry out ball milling, institute
The rotating speed for stating ball mill is 200r/min, Ball-milling Time 60min, the Chinese medicine composition for the lumbocrural pain that obtains medical treatment.
The auxiliary agent is beta-cyclodextrin.
Embodiment 3
The Chinese medicine composition for treating lumbocrural pain, is prepared by the raw material of following weight parts：30 parts of Radix Angelicae Sinensis, Herba Lycopi 30
Part, 30 parts of akebi, 30 parts of cassia twig.
The preparation method of the Chinese medicine composition of the treatment lumbocrural pain, includes the following steps：
(1) each raw material is weighed by weight ratio；
(2) Radix Angelicae Sinensis, Herba Lycopi, akebi, cassia twig be crushed into 40 mesh sieve respectively, is uniformly mixed, obtains Chinese medicine coarse powder；
(3) it is 10 in mass ratio by Chinese medicine coarse powder, auxiliary agent：0.02 after mixing be added ball mill in carry out ball milling, institute
The rotating speed for stating ball mill is 200r/min, Ball-milling Time 60min, the Chinese medicine composition for the lumbocrural pain that obtains medical treatment.
The auxiliary agent is functionalization beta-cyclodextrin.
The functionalization beta-cyclodextrin is prepared by following methods：By beta-cyclodextrin, lauric monoglyceride, sucrose dodecane
Acid esters, gallic acid phytosterin ester are 1 in mass ratio：0.04：0.02：0.01 is uniformly mixed, and crushing sieves with 100 mesh sieve, and obtains
Mixture；The distilled water for adding mixture into mixture weight 20% is uniformly mixed, and twin (double) screw extruder is then added and is squeezed
Pressure, first segment temperature are 50 DEG C, and second segment temperature is 80 DEG C, and third section temperature is 120 DEG C, rotating speed 150r/min, inlet amount
For 3kg/h, obtained material crushed 40 mesh sieve to get functionalization in 55 DEG C of dry 2h, then by obtained material after drying after extruding
Beta-cyclodextrin.
Embodiment 4
The Chinese medicine composition for treating lumbocrural pain, is prepared by the raw material of following weight parts：30 parts of Radix Angelicae Sinensis, Herba Lycopi 30
Part, 30 parts of akebi, 30 parts of cassia twig.
The preparation method of the Chinese medicine composition of the treatment lumbocrural pain, includes the following steps：
(1) each raw material is weighed by weight ratio；
(2) Radix Angelicae Sinensis, Herba Lycopi, akebi, cassia twig be crushed into 40 mesh sieve respectively, is uniformly mixed, obtains Chinese medicine coarse powder；
(3) it is 10 in mass ratio by Chinese medicine coarse powder, auxiliary agent：0.02 after mixing be added ball mill in carry out ball milling, institute
The rotating speed for stating ball mill is 200r/min, Ball-milling Time 60min, the Chinese medicine composition for the lumbocrural pain that obtains medical treatment.
The auxiliary agent is functionalization beta-cyclodextrin.
The functionalization beta-cyclodextrin is prepared by following methods：By beta-cyclodextrin, lauric monoglyceride, sucrose dodecane
Acid esters is 1 in mass ratio：0.04：0.02 is uniformly mixed, and crushing sieves with 100 mesh sieve, and obtains mixture；Add mixture into mixture
The distilled water of weight 20% is uniformly mixed, and twin (double) screw extruder is then added and is squeezed, and first segment temperature is 50 DEG C, second segment
Temperature is 80 DEG C, and third section temperature is 120 DEG C, and rotating speed 150r/min, inlet amount 3kg/h, obtained material is in 55 after extruding
DEG C dry 2h, then obtained material after drying be crushed into 40 mesh sieve to get functionalization beta-cyclodextrin.
Embodiment 5
The Chinese medicine composition for treating lumbocrural pain, is prepared by the raw material of following weight parts：30 parts of Radix Angelicae Sinensis, Herba Lycopi 30
Part, 30 parts of akebi, 30 parts of cassia twig.
The preparation method of the Chinese medicine composition of the treatment lumbocrural pain, includes the following steps：
(1) each raw material is weighed by weight ratio；
(2) Radix Angelicae Sinensis, Herba Lycopi, akebi, cassia twig be crushed into 40 mesh sieve respectively, is uniformly mixed, obtains Chinese medicine coarse powder；
(3) it is 10 in mass ratio by Chinese medicine coarse powder, auxiliary agent：0.02 after mixing be added ball mill in carry out ball milling, institute
The rotating speed for stating ball mill is 200r/min, Ball-milling Time 60min, the Chinese medicine composition for the lumbocrural pain that obtains medical treatment.
The auxiliary agent is functionalization beta-cyclodextrin.
The functionalization beta-cyclodextrin is prepared by following methods：By beta-cyclodextrin, lauric monoglyceride, sucrose dodecane
Acid esters, phytosterol cinnamate are 1 in mass ratio：0.04：0.02：0.01 is uniformly mixed, and crushing sieves with 100 mesh sieve, and is mixed
Close material；The distilled water for adding mixture into mixture weight 20% is uniformly mixed, and twin (double) screw extruder is then added and is squeezed,
First segment temperature is 50 DEG C, and second segment temperature is 80 DEG C, and third section temperature is 120 DEG C, rotating speed 150r/min, and inlet amount is
3kg/h, obtained material crushed 40 mesh sieve to get functionalization β-in 55 DEG C of dry 2h, then by obtained material after drying after extruding
Cyclodextrin.
Embodiment 6
The Chinese medicine composition for treating lumbocrural pain, is prepared by the raw material of following weight parts：30 parts of Radix Angelicae Sinensis, Herba Lycopi 30
Part, 30 parts of akebi, 30 parts of cassia twig.
The preparation method of the Chinese medicine composition of the treatment lumbocrural pain, includes the following steps：
(1) each raw material is weighed by weight ratio；
(2) Radix Angelicae Sinensis, Herba Lycopi, akebi, cassia twig be crushed into 40 mesh sieve respectively, is uniformly mixed, obtains Chinese medicine coarse powder；
(3) it is 10 in mass ratio by Chinese medicine coarse powder, auxiliary agent：0.02 after mixing be added ball mill in carry out ball milling, institute
The rotating speed for stating ball mill is 200r/min, Ball-milling Time 60min, the Chinese medicine composition for the lumbocrural pain that obtains medical treatment.
The auxiliary agent is functionalization beta-cyclodextrin.
The functionalization beta-cyclodextrin is prepared by following methods：By beta-cyclodextrin, lauric monoglyceride, sucrose dodecane
Acid esters, gallic acid phytosterin ester, phytosterol cinnamate are 1 in mass ratio：0.04：0.02：0.007：0.003 mixing
Uniformly, crushing sieves with 100 mesh sieve, and obtains mixture；The distilled water for adding mixture into mixture weight 20% is uniformly mixed, then
Twin (double) screw extruder is added to be squeezed, first segment temperature is 50 DEG C, and second segment temperature is 80 DEG C, and third section temperature is 120 DEG C,
Rotating speed is 150r/min, inlet amount 3kg/h, after extruding obtained material in 55 DEG C of dry 2h, then will it is dry after obtained material powder
40 mesh of broken mistake sieves to get functionalization beta-cyclodextrin.
Test case 1
The Chinese medicine composition of the treatment lumbocrural pain of embodiment 2-6 is subjected to treatment knee osteoarthritis measure of merit.
1, patient data
150 Patients with Knee Osteoarthritis are selected, the course of disease was at 2 years to 3 years, age 50-65 Sui, average age 55 years old；By 150
Example patient is randomly divided into 5 groups, uses the Chinese medicine composition of the treatment lumbocrural pain of embodiment 1-5 respectively.
2, diagnostic criteria
Reference《Rheumatism branch of Chinese Medical Association arthritis diagnosis and treatment draft guidelines gonitis diagnostic criteria in 2002》It is quasi-
It is fixed：
1. nearly one month frequent gonalgia repeatedly；2. X-ray film (erect position or Weight carrying position) joint space narrows；3. closing
Save liquid (at least 2 times) limpid, sticky, WBC≤200/ml；4. person in middle and old age person (>=40 years old)；5. knee joint morning stiffness≤30 minute；⑥
There is fricative when movable.Meet and 1. 2. or 3. 5. 6. or 1. 4. 5. 6. constitutes diagnosis.According to sign：1. gonalgia, row
Walk dysfunction, exacerbation of symptoms when tired and stair activity involves periarticular muscles pain.2. the unrestrained swollen, kneecap of physical examination knee joint
Tenderness at bone and inside and outside Xiyan+, kneecap grinds pain, and floating patella test+, knee joint stretches that flex is limited, and quadriceps muscle of thigh withers
Contracting.
3, therapy
Treatment time is 6 weeks, takes the Chinese medicine composition of 200g treatment lumbocrural pains to be added in 1000g water daily and decocts 1h,
Decocting liquid is taken orally, twice daily, oral decocting liquid measure is 200g every time.
4, treatment results：
4.1 treatment evaluation criteria, are formulated according to State Administration of Traditional Chinese Medicine《Chinese medical disease Standardization of diagnosis and curative effect》Judgement：
Clinical cure：Knee joint swelling, pain disappear, and flexion-extension motion range restores normal, and walking is freely；
It is effective：Knee joint swelling disappears substantially or apparent decline, and pain is substantially reduced, and flexion-extension motion range is normal；
It improves：Knee joint swelling and pain have to be mitigated and alleviates in various degree, and flexion-extension motion range also has improvement；
In vain：Knee joint swelling and pain are without alleviation.
Specific treatment results are shown in Table 1.
Table 1：Therapeutic effect tables of data
| Clinical cure | It is effective | It improves | In vain | |
| Embodiment 2 | 13 | 5 | 8 | 4 |
| Embodiment 3 | 16 | 7 | 5 | 2 |
| Embodiment 4 | 14 | 6 | 7 | 3 |
| Embodiment 5 | 16 | 6 | 5 | 3 |
| Embodiment 6 | 18 | 7 | 4 | 1 |
Test case 2
The Chinese medicine composition of the treatment lumbocrural pain of embodiment 2-6 is subjected to DPPH free radical scavenging ability tests.It takes
The Chinese medicine composition of 200g treatment lumbocrural pains, which is added in 1000g water, decocts 1h, obtains decocting liquid.
The clearance rate of DPPH free radicals measures：Using DPPH methods.DPPH accurately is weighed, is configured to 0.2mmol/LDPPH's
Solution is protected from light Cord blood in brown bottle.Decocting liquid is diluted to 100mg/mL with deionized water, obtains sample liquid.Take 2mL,
100mg/mL sample liquids are uniformly mixed in 2mL, 0.2mmol/LDPPH solution in test tube, is added, and are protected from light stand 30min at room temperature
Afterwards, absorbance value at 517nm is measured with ultraviolet specrophotometer UV-2000 (You Nike (Shanghai) limited instrument company), be calculated as
Ai, while measuring 2mL, 100mg/mL sample liquid and adding 2mL absolute ethyl alcohols, it is protected from light at room temperature after standing 30min, with ultraviolet spectrometry light
Degree meter UV-2000 (You Nike (Shanghai) limited instrument company) measure at 517nm absorbance value, be calculated as Aj and 2mL,
0.2mmol/LDPPH solution adds 2ml distilled water to stand, with ultraviolet specrophotometer UV-2000 (You Nike (Shanghai) limited instruments
Company) absorbance value at 517nm is measured, it is calculated as Ac.The clearance rate of DPPH free radicals is calculated as follows in sample：Clearance rate=
[1- (Ai-Aj)/Ac] × 100%.
Specific treatment results are shown in Table 2.
Table 2：DPPH free radical scavenging activity tables of data
The present invention treats the Chinese medicine composition of lumbocrural pain, chooses natural traditional Chinese medicine scientific compatibility, formula is simple, each bulk pharmaceutical chemicals
Synergistic effect plays promote breath and open depression, promoting blood circulation and stopping pain, expelling wind and eliminating dampness, the effect of eliminating cold to stop pain, and embodiment 3 changes preparation method
Into processing, the auxiliary agent of addition not only contributes to promote when in use the leaching of active ingredient, it is thus also avoided that process Chinese medicine
The loss of active ingredient, drug effect are improved significantly.
Claims (10)
1. a kind of Chinese medicine composition for treating lumbocrural pain, which is characterized in that be prepared by following raw materials：Radix Angelicae Sinensis, Herba Lycopi, wood
Logical, cassia twig.
2. a kind of Chinese medicine composition for treating lumbocrural pain, which is characterized in that be prepared by the raw material of following weight parts：Radix Angelicae Sinensis
20-40 parts, 20-40 parts of Herba Lycopi, 20-40 parts of akebi, 20-40 parts of cassia twig.
3. the preparation method of the Chinese medicine composition for the treatment of lumbocrural pain as claimed in claim 2, which is characterized in that including following
Step：
(1) each raw material is weighed by weight ratio；
(2) Radix Angelicae Sinensis, Herba Lycopi, akebi, cassia twig are uniformly mixed to obtain the final product.
4. the preparation method of the Chinese medicine composition for the treatment of lumbocrural pain as claimed in claim 2, which is characterized in that including following
Step：
(1) each raw material is weighed by weight ratio；
(2) Radix Angelicae Sinensis, Herba Lycopi, akebi, cassia twig be crushed into 20-50 mesh sieve respectively, is uniformly mixed, obtains Chinese medicine coarse powder；
(3) Chinese medicine coarse powder, auxiliary agent are added in ball mill and carry out ball milling, the Chinese medicine composition for the lumbocrural pain that obtains medical treatment.
5. the preparation method of the Chinese medicine composition for the treatment of lumbocrural pain as claimed in claim 4, which is characterized in that the Chinese medicine
Coarse powder, auxiliary agent mass ratio be 10：(0.01-0.03).
6. the preparation method of the Chinese medicine composition for the treatment of lumbocrural pain as claimed in claim 4, which is characterized in that the auxiliary agent
For beta-cyclodextrin.
7. the preparation method of the Chinese medicine composition for the treatment of lumbocrural pain as claimed in claim 4, which is characterized in that the auxiliary agent
For functionalization beta-cyclodextrin, the functionalization beta-cyclodextrin is prepared by following methods：By beta-cyclodextrin, lauric monoglyceride,
Sucrose dodecanoate is 1 in mass ratio：(0.03-0.06)：(0.01-0.05) is uniformly mixed, and be crushed 80-120 mesh sieve, is obtained
To mixture；The water for adding mixture into mixture weight 10-30% is uniformly mixed, and twin (double) screw extruder is then added and is squeezed
Pressure, first segment temperature are 40-60 DEG C, and second segment temperature is 70-90 DEG C, and third section temperature is 110-140 DEG C, rotating speed 100-
200r/min, inlet amount 2-4kg/h, after extruding obtained material in 50-60 DEG C of dry 1-3h, then will it is dry after obtained material powder
It is broken cross 30-80 mesh sieve to get.
8. the preparation method of the Chinese medicine composition for the treatment of lumbocrural pain as claimed in claim 4, which is characterized in that the auxiliary agent
For functionalization beta-cyclodextrin, the functionalization beta-cyclodextrin is prepared by following methods：By beta-cyclodextrin, lauric monoglyceride,
Sucrose dodecanoate, phytosterin ester are 1 in mass ratio：(0.03-0.06)：(0.01-0.05)：(0.005-0.02) is mixed
Uniformly, 80-120 mesh sieve is crushed, mixture is obtained；The water for adding mixture into mixture weight 10-30% is uniformly mixed, so
Twin (double) screw extruder is added afterwards to be squeezed, first segment temperature is 40-60 DEG C, and second segment temperature is 70-90 DEG C, third section temperature
It it is 110-140 DEG C, rotating speed 100-200r/min, inlet amount 2-4kg/h, obtained material is in 50-60 DEG C of dry 1- after extruding
3h, then by obtained material after drying crushed 30-80 mesh sieve to get.
9. the preparation method of the Chinese medicine composition for the treatment of lumbocrural pain as claimed in claim 7 or 8, which is characterized in that described
Phytosterin ester is gallic acid phytosterin ester and/or phytosterol cinnamate.
10. the preparation method of the Chinese medicine composition for the treatment of lumbocrural pain as claimed in claim 4, which is characterized in that the ball
The rotating speed of grinding machine is 150-250r/min, Ball-milling Time 40-80min.
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| CN111000907A (en) * | 2019-12-23 | 2020-04-14 | 朱细贵 | Traditional Chinese medicine for treating lumbocrural pain and preparation method thereof |
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