CN108434007A - A kind of disposable foam liquid soap and preparation method thereof of prevention hand-foot-and-mouth disease - Google Patents
A kind of disposable foam liquid soap and preparation method thereof of prevention hand-foot-and-mouth disease Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The invention discloses a kind of disposable foam liquid soaps and preparation method thereof of prevention hand-foot-and-mouth disease.The disposable foam liquid soap that the present invention makes there is significant inhibiting effect, 1099 dosages of active ingredient TJAB can reach antiviral efficacy in μM rank hand-foot-and-mouth disease virus, and being capable of long-acting bacteriostatic, protection skin.Disposable foam type hand cleanser is easy to use, is particularly suitable for using in outdoor activities and travelling.
Description
Technical field
The present invention relates to disposable foam liquid soaps, more particularly to a kind of disposable foam that can prevent hand-foot-and-mouth disease
Hand cleanser is especially suitable for children and uses.
Background technology
People's hand-foot-and-mouth disease (Hand-foot-mouth disease, HFMD) is anxious caused by a variety of enterovirus infections
Sexually transmitted disease, it is most commonly seen with enterovirns type 71 (EV 71) in China.Hand-foot-and-mouth disease is globally distributed, and is fallen ill in recent years
Rate is in rising trend, can distribute or prevalence is fallen ill, morbidity season is mostly in summer, five years old or less child morbidity highest, Annual wool yield
And adult can also be infected.Occurs heating paresthesia when onset, oral mucosa occurs being dispersed in bleb, and spot mound occur in brothers and buttocks
Rash, bleb, can there is inflammatory blush around bleb, and liquid is less in blister.And with symptoms such as cough, runny nose, loss of appetite.It is a small number of
Case, especially EV71 infect infant, may occur in which meningitis, encephalitis, encephalomyelitis, neural source, property pulmonary edema, dyshaemia
Deng the state of an illness is dangerous, lethal can die or there are sequelae.
China is the region occurred frequently of hand-foot-and-mouth disease, and patient base is larger, seriously affects the health of children.Market today
On have the antibacterial class hand cleanser of numerous disinfections, but there is no the class product of washing one's hands specifically for hand-foot-and-mouth disease, products of the invention
It will can overcome the disadvantages that this present situation.The principle active component TJAB-1099 of the present invention is institute of Tianjin International Joint Academy of Biotechnology ＆ Medicine
Long rich son and one kind of team's research and development are directed to the highly efficient depressor of hand-foot-and-mouth disease virus, using this drug as made of main component
Liquid energy of washing one's hands specifically kills virus, has the characteristics that efficient, safety is good.
The structural formula of TJAB-1099 is as follows：Wherein, R is hydrogen, C1-C5The various substituent groups such as alkyl；
However TJAB-1099 is a kind of slightly water-soluble compound, water solubility limits its oral absorption rate, makes its clinic
It is greatly limited using with formulation development.
Invention content
The present invention provides a kind of disposable foam liquid soap that can prevent hand-foot-and-mouth disease, the active ingredient of hand cleanser is
(Chinese patent CN104744433 A, data of publication of application are July 1 in 2015 to the highly efficient depressor TJAB-1099 of EV71 viruses
Day).This product inhibits virus effectiveness apparent, and safety is good, is particularly suitable for hospital and children use.
The present invention provides a kind of disposable foam liquid soap preventing hand-foot-and-mouth disease, the component containing following weight ratio：
TJAB-1099：0.00002%~0.00006%, Span 20：0.000001%~0.000005%, surfactant
APG1200：1%~10%, ethyl alcohol：40%~65%, glycerine：1%~4%, propylene glycol：1%~3%, essence：0.1%~
1%, remaining is deionized water；Wherein, the structural formula of TJAB-1099 is as follows：
Wherein, R is hydrogen, C1-C5Alkyl.
In above-mentioned disposable foam liquid soap, wherein the production method of the disposable foam liquid soap includes：By Span
20 are added mixing in ethyl alcohol, add TJAB-1099, make it completely dissolved, solution A is made；Take glycerine, propylene glycol, essence with
And solution A is dissolved in ethyl alcohol, B solution is made in mixing；Surfactant A PG-1200 is added while stirring in water, it is fully mixed
It closes, C solution is made；C solution is added in B solution, it is stirring while adding, form uniform disposable foam liquid soap.
In above-mentioned disposable foam liquid soap, wherein the disposable foam liquid soap is leave.
In above-mentioned disposable foam liquid soap, wherein the pH of the disposable foam liquid soap is between 6.5~10.
In above-mentioned disposable foam liquid soap, wherein the disposable foam liquid soap inactivation EV71 viruses.
In above-mentioned disposable foam liquid soap, the component containing following weight ratio：TJAB-1099：0.00004%%,
Span 20：0.000001%, surfactant A PG1200：2%, ethyl alcohol：40%, glycerine：3%, propylene glycol：2%, essence：
0.1%, remaining is deionized water.
The technical advantage of the present invention is as follows：
Chinese patent CN104744433A (data of publication of application：On July 1st, 2015) disclose EV71 viral inhibitors
(TJAB-1099), which can be effectively blocked duplication of the EV71 viruses in human body, to specificity treatment by
Hand-foot-and-mouth disease caused by EV71 viruses.Active ingredient in the present invention is TJAB-1099, can be reached in very low amounts level
Antiviral effect.
The disposable foam hand sanitizing fluid preparation process of the present invention is simple, and it is foam to be squeezed out by special Foam bottle, easy to use
Simply.
Surfactant used is alkyl glycosides APG-1200 in the product of the present invention, it be of new generation mild, green,
Environment-friendly type surfactant, foamability is strong, and foam is fine and smooth, abundant, stable, and wetability is good, strong detergency, to human skin temperature
With, it is green, nontoxic, non-stimulated, it is biodegradable rapid thorough.
It is especially added with qs glycerin, propylene glycol in the product of the present invention, there is significant moistening effect, can be reduced due to frequency
Numerous caused chapped skin sense of washing one's hands, keeps moisture of skin.
The product specificity of the present invention is directed to hand-foot-and-mouth disease, and in wash product, there is no dedicated for anti-brothers mouthful in the market
The Related product of disease, hand cleanser of the invention can greatly be that people's health especially pediatric population provides safeguard.
The product of the present invention is particularly suitable for children and uses, and is also very suitable for the use of the places such as school, kindergarten, hospital.
Description of the drawings
Fig. 1 shows the inhibition of the product of the application, business hand cleanser and negative control to virus.
Specific implementation mode
The present invention is specifically addressed below in conjunction with specific case study on implementation, but protection scope of the present invention is not limited only to
This.
The present invention provides a kind of disposable foam liquid soap that can prevent hand-foot-and-mouth disease, ingredient includes：Surface-active
Agent APG-1200, Span 20, ethyl alcohol, glycerine, propylene glycol, essence, TJAB-1099 and deionized water, it is characterized in that containing EV71
The highly efficient depressor TJAB-1099 of virus.
The foam liquid soap of the present invention that can prevent hand-foot-and-mouth disease, contains following weight ratio ingredient：TJAB-
1099：0.00002%~0.00006%, Span 20：0.000001%~0.000005%, surfactant A PG1200：
1%~10%, ethyl alcohol：40%~65%, glycerine：1%~4%, propylene glycol：1%~3%, essence：0.1%~1%, remaining
For deionized water.
The production method of leakage of liquid of the present invention is as follows：
Mixing in ethyl alcohol is added in Span 20, TJAB-1099 is added, makes it completely dissolved, solution A is made；
Glycerine, propylene glycol, essence and solution A is taken to be dissolved in ethyl alcohol, B solution is made in mixing；
Batch mixing：Surfactant A PG-1200 is added while stirring in water, is sufficiently mixed, C solution is made；Then in B
Whole C solutions are added in solution, it is stirring while adding, form uniform hand cleanser.
Hand cleanser of the present invention is leave, and foaming abundancy, sensory effects are preferable, the odor type with different tastes,
Especially it is more conform with the organoleptic requirements of children.
Hand cleanser pH of the present invention meets the standard of related hand cleanser, neutrality to alkalescence can between 6.5~10
It is preferably antibacterial, antiviral.
Leakage of liquid of the present invention inhibit the validation checking of hand-foot-and-mouth disease Causative virus, finds this product energy
Enough effectively inactivation EV71 viruses.
Embodiment 1：A kind of disposable foam liquid soap of prevention hand-foot-and-mouth disease
Preparation method：
It takes 100 μ g Span 20 that mixing in 100ml ethyl alcohol is added, adds 4.25mg TJAB-1099 (for example, make herein
R in TJAB-1099 is H), stirring, which makes it completely dissolved, is made solution A；Take glycerine 3ml, propylene glycol 2ml, essence
0.1ml and solution A 1ml are dissolved in 39ml ethyl alcohol, and B solution is made in mixing；Then in 54.9ml deionized waters while stirring
2g surfactant A PG-1200 are added, is sufficiently mixed, C solution is made；Whole C solutions, side edged are finally added in B solution
Stirring, forms uniform hand cleanser.
The disposable foam liquid soap of the present embodiment 1 forms such as known to the preparation method of the leakage of liquid of the present embodiment
Under：
TJAB-1099：0.00004%, Span20：0.000001%, surfactant A PG1200：2%, ethyl alcohol：
40%, glycerine：3%, propylene glycol：2%, essence：0.1%, deionized water：About 54.9%.
Using similar method, it is prepared for the disposable foam liquid soap of embodiment 2 and 3.
The composition of the hand cleanser of embodiment 2 is as follows：
TJAB-1099：0.00002%, Span20：0.000003%, surfactant A PG1200：5%, ethyl alcohol：
55%, glycerine：1%, propylene glycol：1%, essence：0.5%, deionized water：About 37.5%.
The composition of the hand cleanser of embodiment 3 is as follows：
TJAB-1099：0.00006%, Span20：0.000005%, surfactant A PG1200：10%, ethyl alcohol：
65%, glycerine：4%, propylene glycol：3%, essence：1%, deionized water：About 17%.
Illustrate that hand cleanser inhibits the validation checking method and knot of hand-foot-and-mouth disease Causative virus by taking embodiment 1 as an example below
Fruit：
The culture of 1.RD cells
It will be solved in 37 DEG C of water-baths of the RD cells frozen in liquid nitrogen (being commercially available from Chinese Academy of Medical Sciences's cell bank)
It after jelly, is added in the culture bottle for filling 20ml culture mediums, medium component is DMEM (Dulbecco's modified
Eagle medium)+10% fetal calf serum (Fetal Bovine Serum, FBS)+1% penicillin and streptomysin
(Penicillin-Streptomycin, PS), 37 DEG C, 5%CO2Culture.
2.EV71 the amplification of virus
When cell growth to full scale is 90%, EV71 viral (kind of EV71 viruses, acquisition methods, experiment side is added
Method and store method are that the patent CN104744433A on July 1st, 2015 is consistent with publication date) 200 μ L, 37 DEG C, 5%CO2Training
It supports.Lesion occurs for cell after for 24 hours, and supernatant is collected after the complete lesion of cell, and 4000rpm centrifuges 10min, freezes after supernatant is dispensed
It is stored in -80 DEG C.
3.EV71 virus titers measure
Measure virus titer with Endpoint Dilution Method (endpoint dilution assays, EPDAs), RD cells by 3 ×
105/ml is inoculated in 96 orifice plates, 37 DEG C, and after 5%CO2 cultures for 24 hours, the culture medium in 6 holes of secondary series is siphoned away, is added 110
The virus that μ L freeze takes 11 μ l viruses to be added to third row, takes 11 μ l to be then added to third from third row after mixing and arrange from secondary series,
It is diluted to the tenth row successively, the 11st is classified as cell controls, and the micro- sem observation induced cytopathic effect of Olympus is utilized after 72h
(cytopathic effect, CPE) is simultaneously recorded.Be denoted as if hole inner cell lesion 25%+, lesion 50% is denoted as ++, lesion
75% is denoted as +++, lesion 100% is denoted as ++++.Half array of virus is calculated using software Reed＆Muench Calculator
Knit culture infective dose (Tissue culture infective dose, TCID50).
4. the calculating of Endpoint Dilution Method virus infection titer
It is indicated with half cell infection dosage (TCID50).The logarithm calculation formula of TCID50 is as follows.TCID50 logarithms
Higher than logarithm+distance proportion of 50% group of dilution, (" lesion rate be higher than 50% group " refers to that lesion rate is more than to value=lesion rate
Minimum group of 50%, lower abbreviation " being higher than 50% group "；" lesion rate is less than 50% group " refers to the highest group that lesion rate is less than 50%,
Lower abbreviation " being less than 50% group ").
Circular is as follows：
1) cytopathy variability is calculated.Different dilution sample cytopathies on culture plate are first counted to occur and nonevent hole
Number, then calculates separately the accumulation aggregate values of " cell is without lesion (-) " and " cytopathy (+) ".It calculates " cell is without lesion (-) "
When accumulated value, accumulated from the low sample group of dilution to the high sample group of dilution；" cytopathy (+) " accumulated value is then on the contrary, by dilute
The high sample group of degree of releasing is accumulated to the low sample group of dilution.Each dilution sample group " cytopathy (+) " accumulates aggregate values, divided by should
The sum of dilution sample group " cell is without lesion (-) " and " cytopathy (+) " accumulation aggregate values are its lesion ratio, can be obtained by it
Lesion rate (%).
2) distance proportion is calculated, distance proportion can be calculated as follows：
5. the experimental method of hand cleanser inactivation EV71 viruses prepared by embodiment 1
1. the preparation of 1% Ago-Gel
1.2g agarose M are weighed, are dissolved in 120mL 1*TAE buffer solutions, 121 DEG C of high-temperature sterilization 20min, in bio-safety
The Ago-Gel of 2mL is added in cabinet into each hole of two six orifice plates, is cooled to room temperature solidification.
2. being grouped
It is divided into product group of the present invention, business hand cleanser group (imported from America Purell), negative control group
3. hand cleanser is to EV71 inactivation of virus experimental procedures
A. 100 μ L hand cleanser (experimental group or control group) or sterilizing ddH are added in every hole2O, with disposable spreading rod
Smear uniform, the air-dried 2h in Biohazard Safety Equipment；
B. the 0 μ L of virus 5 that virus titer is 3 × 109TCID50/mL are added, smear uniform；
C.2h after, 500 μ L cell culture fluids elution virus is added in every hole, 800rpm centrifuges 3min, takes supernatant, use terminal
Dilution method surveys virus titer.
4. Endpoint Dilution Method measures virus titer
Method is same as above.
6. experimental result
4th day, observation was as a result, such as Fig. 1, the results show that liquid energy of washing one's hands prepared by embodiment 1 effectively (effectively inactivates
Standard is that cytopathic effect CPE is 90% or more) inactivation EV71 viruses.
Hand cleanser pH value assay method and result：
At room temperature, with the distilled water 1 for newly boiling and cooling down:The sample solution of 10 (W/V), mixing and with pH meter to implement
Example 1 is measured, and it is 7 to measure its pH.
Similarly, using similar method, confirm that hand cleanser prepared by embodiment 2 and embodiment 3 also can be inactivated effectively
EV71 viruses.For simplicity, it is not described in detail herein.In addition, measuring the pH of hand cleanser prepared by embodiment 2 and embodiment 3
Respectively 6.9 and 7.5.
The hand cleanser of the present invention overcomes the slightly water-soluble of compound TJAB-1099 this problem, makes compound TJAB-
1099 directly act on hand virus, reach the control effect to hand-foot-and-mouth disease.The disposable foam liquid soap pair that the present invention makes
There is hand-foot-and-mouth disease virus significant inhibiting effect, active ingredient TJAB-1099 dosages can reach antiviral in μM rank
Effect, and being capable of long-acting bacteriostatic, protection skin.Disposable foam type hand cleanser is easy to use, is particularly suitable for outdoor activities and trip
It is used in row.
Claims (6)
1. a kind of disposable foam liquid soap preventing hand-foot-and-mouth disease, the component containing following weight ratio：TJAB-1099：
0.00002%~0.00006%, Span 20：0.000001%~0.000005%, surfactant A PG1200：1%~
10%, ethyl alcohol：40%~65%, glycerine：1%~4%, propylene glycol：1%~3%, essence：0.1%~1%, remaining for go from
Sub- water；
Wherein, the structural formula of TJAB-1099 is as follows：
Wherein, R is hydrogen, C1-C5Alkyl.
2. disposable foam liquid soap according to claim 1, wherein the production method packet of the disposable foam liquid soap
It includes：
Mixing in ethyl alcohol is added in Span 20, TJAB-1099 is added, makes it completely dissolved, solution A is made；
Glycerine, propylene glycol, essence and solution A is taken to be dissolved in ethyl alcohol, B solution is made in mixing；
Surfactant A PG-1200 is added while stirring in water, is sufficiently mixed, C solution is made；
C solution is added in B solution, it is stirring while adding, form uniform disposable foam liquid soap.
3. disposable foam liquid soap according to claim 1, wherein the disposable foam liquid soap is leave.
4. disposable foam liquid soap according to claim 1, wherein the pH of the disposable foam liquid soap is 6.5~10
Between.
5. disposable foam liquid soap according to claim 1, wherein the disposable foam liquid soap inactivation EV71 viruses.
6. disposable foam liquid soap according to claim 1, the component containing following weight ratio：TJAB-1099：
0.00004%%, Span 20：0.000001%, surfactant A PG1200：2%, ethyl alcohol：40%, glycerine：3%, the third two
Alcohol：2%, essence：0.1%, remaining is deionized water.
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| CN201710083823.9A CN108434007A (en) | 2017-02-16 | 2017-02-16 | A kind of disposable foam liquid soap and preparation method thereof of prevention hand-foot-and-mouth disease |
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| CN201710083823.9A CN108434007A (en) | 2017-02-16 | 2017-02-16 | A kind of disposable foam liquid soap and preparation method thereof of prevention hand-foot-and-mouth disease |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5644041A (en) * | 1993-03-23 | 1997-07-01 | Akzo Nobel Nv | Alkyl glycoside its use for cleaning purposes, and cleaning composition |
| CN102526087A (en) * | 2010-12-30 | 2012-07-04 | 南开大学 | Application of nucleoside compound to preparation of medicament for treating enterovirus 71 (EV71) infectious disease |
| CN103505384A (en) * | 2012-06-25 | 2014-01-15 | 江苏天一健消毒剂有限公司 | Antibacterial skin-moisturizing hand-washing liquid |
| CN104744433A (en) * | 2013-12-30 | 2015-07-01 | 中国科学院生物物理研究所 | ALD and application thereof as EV71 virus and CAV16 virus inhibitor |
-
2017
- 2017-02-16 CN CN201710083823.9A patent/CN108434007A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5644041A (en) * | 1993-03-23 | 1997-07-01 | Akzo Nobel Nv | Alkyl glycoside its use for cleaning purposes, and cleaning composition |
| CN102526087A (en) * | 2010-12-30 | 2012-07-04 | 南开大学 | Application of nucleoside compound to preparation of medicament for treating enterovirus 71 (EV71) infectious disease |
| CN103505384A (en) * | 2012-06-25 | 2014-01-15 | 江苏天一健消毒剂有限公司 | Antibacterial skin-moisturizing hand-washing liquid |
| CN104744433A (en) * | 2013-12-30 | 2015-07-01 | 中国科学院生物物理研究所 | ALD and application thereof as EV71 virus and CAV16 virus inhibitor |
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