CN108421042B - 一种光控降解水凝胶的制备方法 - Google Patents
一种光控降解水凝胶的制备方法 Download PDFInfo
- Publication number
- CN108421042B CN108421042B CN201810340492.7A CN201810340492A CN108421042B CN 108421042 B CN108421042 B CN 108421042B CN 201810340492 A CN201810340492 A CN 201810340492A CN 108421042 B CN108421042 B CN 108421042B
- Authority
- CN
- China
- Prior art keywords
- hydrogel
- aqueous solution
- light
- sodium alginate
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000017 hydrogel Substances 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 claims abstract description 47
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 36
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 27
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 27
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 27
- 239000000661 sodium alginate Substances 0.000 claims abstract description 27
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 23
- 239000003504 photosensitizing agent Substances 0.000 claims abstract description 20
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 18
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 18
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 18
- 238000002156 mixing Methods 0.000 claims abstract description 15
- 239000007864 aqueous solution Substances 0.000 claims description 54
- 229920000642 polymer Polymers 0.000 claims description 17
- 230000015556 catabolic process Effects 0.000 claims description 10
- 238000006731 degradation reaction Methods 0.000 claims description 10
- 150000002148 esters Chemical class 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- 125000002080 perylenyl group Chemical group C1(=CC=C2C=CC=C3C4=CC=CC5=CC=CC(C1=C23)=C45)* 0.000 claims description 2
- CSHWQDPOILHKBI-UHFFFAOYSA-N peryrene Natural products C1=CC(C2=CC=CC=3C2=C2C=CC=3)=C3C2=CC=CC3=C1 CSHWQDPOILHKBI-UHFFFAOYSA-N 0.000 claims description 2
- -1 phenylboronic acid ester Chemical class 0.000 claims 1
- 239000000499 gel Substances 0.000 abstract description 19
- 239000000463 material Substances 0.000 abstract description 3
- 230000001105 regulatory effect Effects 0.000 abstract description 3
- 239000002246 antineoplastic agent Substances 0.000 abstract description 2
- 229940041181 antineoplastic drug Drugs 0.000 abstract description 2
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 238000003756 stirring Methods 0.000 description 14
- 238000003860 storage Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001782 photodegradation Methods 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- JMZFEHDNIAQMNB-UHFFFAOYSA-N m-aminophenylboronic acid Chemical compound NC1=CC=CC(B(O)O)=C1 JMZFEHDNIAQMNB-UHFFFAOYSA-N 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000012781 shape memory material Substances 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000013269 sustained drug release Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810340492.7A CN108421042B (zh) | 2018-04-17 | 2018-04-17 | 一种光控降解水凝胶的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810340492.7A CN108421042B (zh) | 2018-04-17 | 2018-04-17 | 一种光控降解水凝胶的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108421042A CN108421042A (zh) | 2018-08-21 |
CN108421042B true CN108421042B (zh) | 2021-02-09 |
Family
ID=63161217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810340492.7A Active CN108421042B (zh) | 2018-04-17 | 2018-04-17 | 一种光控降解水凝胶的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108421042B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110144051B (zh) * | 2019-05-15 | 2022-03-15 | 长春工业大学 | 一种pva海藻酸钠双网络耐寒导电水凝胶及其制备方法 |
CN113209375B (zh) * | 2021-04-21 | 2023-01-06 | 温州医科大学 | 一种基于芳基硼酸酯交联的具有自修复和可注射性能的水凝胶的制备方法及应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104557932A (zh) * | 2014-12-31 | 2015-04-29 | 南京邮电大学 | 一种苝酰亚胺类近红外吸收材料的高效合成方法及其应用 |
CN105078890A (zh) * | 2015-08-18 | 2015-11-25 | 江南大学 | 一种可释放胰岛素的多层生物基囊泡的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120065614A1 (en) * | 2010-09-10 | 2012-03-15 | University Of North Texas | Polyionic transitional metal phosphorescent complex/polymer hybrid systems for bioimaging and sensing applications |
EP2766049A1 (en) * | 2011-10-14 | 2014-08-20 | Photocure ASA | Photodynamic diagnosis of abnormalities of the epithelial lining of the oesophagus with the means of a 5-ala ester |
CN103193944B (zh) * | 2013-04-09 | 2015-08-19 | 苏州大学 | 一种具有肿瘤靶向性及可见光降解性的两亲性聚合物、药物载体及其制备方法 |
CN104710625B (zh) * | 2015-03-19 | 2017-03-08 | 南京邮电大学 | 一种近红外响应可降解水溶性共聚物及其高效合成方法 |
CN107501363B (zh) * | 2017-07-24 | 2019-12-03 | 福建医科大学孟超肝胆医院(福州市传染病医院) | 一种具有光响应降解的阿霉素前体化合物及其制备与应用 |
-
2018
- 2018-04-17 CN CN201810340492.7A patent/CN108421042B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104557932A (zh) * | 2014-12-31 | 2015-04-29 | 南京邮电大学 | 一种苝酰亚胺类近红外吸收材料的高效合成方法及其应用 |
CN105078890A (zh) * | 2015-08-18 | 2015-11-25 | 江南大学 | 一种可释放胰岛素的多层生物基囊泡的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN108421042A (zh) | 2018-08-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
El-Husseiny et al. | Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications | |
Teng et al. | Recent development of alginate-based materials and their versatile functions in biomedicine, flexible electronics, and environmental uses | |
Khan et al. | Synthesis, classification and properties of hydrogels: Their applications in drug delivery and agriculture | |
Tan et al. | Development of alginate-based hydrogels: Crosslinking strategies and biomedical applications | |
Liu et al. | Synthesis and biomedical applications of self-healing hydrogels | |
Mahinroosta et al. | Hydrogels as intelligent materials: A brief review of synthesis, properties and applications | |
Gholamali | Stimuli-responsive polysaccharide hydrogels for biomedical applications: a review | |
Ye et al. | Advances in hydrogels based on dynamic covalent bonding and prospects for its biomedical application | |
Malviya et al. | Modification of polysaccharides: Pharmaceutical and tissue engineering applications with commercial utility (patents) | |
Uliniuc et al. | New approaches in hydrogel synthesis—Click chemistry: A review | |
US11345785B2 (en) | Processing method for intelligent hydrogel from nanometer starch particles | |
CN107233629B (zh) | 可注射水凝胶及其制备和应用 | |
CN109745579B (zh) | 一种具有导电性能的可注射自愈合水凝胶及其制备方法 | |
CN108421042B (zh) | 一种光控降解水凝胶的制备方法 | |
CN113197843A (zh) | 一种多巴胺涂覆的纤维素纳米晶-琼脂糖载药水凝胶及其制备方法 | |
Chatterjee et al. | A detailed discussion on interpenetrating polymer network (IPN) based drug delivery system for the advancement of health care system | |
CN107325300B (zh) | 一种pH敏感水凝胶及其制备和应用 | |
Hu et al. | Recent advances in smart‐responsive hydrogels for tissue repairing | |
CN115400071A (zh) | 负载非水溶性眼内药物控释的可注射水凝胶及其制备方法 | |
CN106750416B (zh) | 一种拥有自愈合和pH响应性能的可注射水凝胶及其制备方法和应用 | |
CN107595767A (zh) | 一种拥有对电刺激和pH双重响应性能的抗菌可注射水凝胶及其制备方法和应用 | |
CN110180023B (zh) | 一种高强度生物质组织工程支架材料的制备方法 | |
MohanKumar et al. | Hydrogels: potential aid in tissue engineering—a review | |
CN109337098B (zh) | 一种酶响应型结肠靶向载药凝胶的制备方法 | |
Zhang et al. | Polysaccharide based supramolecular injectable hydrogels for in situ treatment of bladder cancer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20240527 Address after: No. 2-608, Ruibo Building, No. 224 Kaiyuan Avenue, Luolong District, Luoyang City, Henan Province, 471023 Patentee after: Luoyang Jianzhuo Intellectual Property Agency Co.,Ltd. Country or region after: China Address before: 210023 9 Wen Yuan Road, Ya Dong new town, Nanjing, Jiangsu. Patentee before: NANJING University OF POSTS AND TELECOMMUNICATIONS Country or region before: China |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20240609 Address after: 030621 No. 111 Taigu Street, Private Science and Technology Park, Huitong Industrial Park, Jinzhong Development Zone, Shanxi Demonstration Zone, Jinzhong City, Shanxi Province Patentee after: SHANXI HAIQINGYUAN BIOTECHNOLOGY CO.,LTD. Country or region after: China Address before: No. 2-608, Ruibo Building, No. 224 Kaiyuan Avenue, Luolong District, Luoyang City, Henan Province, 471023 Patentee before: Luoyang Jianzhuo Intellectual Property Agency Co.,Ltd. Country or region before: China |
|
TR01 | Transfer of patent right |