CN108420772A - A kind of cosmetic composition of depigmentaton and its application - Google Patents
A kind of cosmetic composition of depigmentaton and its application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention discloses a kind of cosmetic composition of depigmentaton and its applications, composition includes mainly the active constituent of elm bark polysaccharide, rice tunning filtrate, Chinese medicine extract, and Chinese medicine is made of Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, the root of Dahurain angelica, the cosmetic composition of depigmentaton can have pigment epithelial cell de- keratinization activity, promote the cell detachment of chromogenesis, and inhibit tyrosinase activity, reduces melanin and formed, wherein elm bark polysaccharide has strong reduction, and effectively removes free radical；Strong absorption of the Radix Glycyrrhizae to ultraviolet light in Chinese medicine extract, and inhibit tyrosine activity, Radix Salviae Miltiorrhizae promotes skin blood circulation, root of Dahurain angelica whitening and skin-protecting；Rice tunning filtrate also desalinates the whitening effect of pigment, composition is applied in preparing cosmetics, the whitening effect of the significant depigmentaton of cosmetics can be assigned while promoting skin moisture absorption.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of cosmetic composition of depigmentaton and its application.
Background technology
Skin is one of barrier of human body, the health status of human body can be reacted to a certain extent again, with natural environment
Variation and ambient pressure with personal physical condition such as continue to increase at the influences, under body itself antioxidant system vigor
Drop, internal oxygen radical increase, and tyrosinase increases, and may result in melanin deposition, generate color spot, cause skin dim.Its
In, cutaneous pigmentation is divided by type chloasma, cyasma, butterfly macules, senile plaque, coffee spot and freckle, is a kind of common
Multiple cutaneous disease.Dyssecretosis in the reason of causing cutaneous pigmentation main someone's body, metabolic function weaken,
Dry skin, aging, solarization, ultraviolet radiation, sleep insufficiency, fatigue etc..With advancing age, color spot increases,
The face appearance for seriously affecting people brings the psychological pressure of aging, to influence quality of life.
China Patent No. 200480011012.9 discloses a kind of cosmetic for depigmentation, includes mainly white orchid section above ground portion
Extract, and it is 0.01~1% that orchid extract, which accounts for cosmetics total weight ratio, has certain whitening effect.China Patent No.
CN107260610A discloses a kind of skin whitener of the analog containing curcumin, including mainly plays whitening by curcumin analogue
The effect of nti-freckle, but action component is single that whitening effect can be caused limited.
At present in research, most of depigmentaton is all to reduce the generation of melanin by inhibiting tyrosinase activity,
And these ingredients of benzenediol, ascorbic acid can be added in the market to carry out desalination pigment, but benzenediol can stimulate skin, therefore
Additive amount is few, and whitening effect is limited, and ascorbic acid has the problem of being easy oxidation, thus be easy to cause cosmetics quality variation and
Whitening effect is reduced, in order to find better safer whitening depigmentaton ingredient, by a variety of natural goods Quality Research,
Obtain the significant product of whitening effect of the present invention.
Invention content
The purpose of the present invention is to provide a kind of cosmetic compositions of depigmentaton, and are applied and preparing cosmetics
In, there can be de- keratinization activity to pigment epithelial cell, promote the cell detachment of chromogenesis, and inhibit tyrosine enzyme activity
Property, reduce the formation of pigment, moreover it is possible to promote the absorption of skin moisture, maintain elasticity of skin, skin is made to keep smooth exquisiteness.
In order to achieve the above object, the present invention provides the following technical solution：
A kind of its active constituent of the cosmetic composition of depigmentaton includes the component of following parts by weight：Elm bark polysaccharide 6~
12 parts, 1~20 part of rice tunning filtrate, 1~20 part of Chinese medicine extract.
In addition, the cosmetic composition of the depigmentaton further includes 15~30 parts of butanediol, 10~25 parts of deionized water.
Preferably, the composition includes 8 parts of elm bark polysaccharide, 10 parts of rice tunning filtrate, Chinese medicine extract
10 parts, 22 parts of butanediol, 18 parts of deionized water.
Wherein, Chinese medicine extract described above by Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, the root of Dahurain angelica according to 1:1~3:1~2 ratio mixing, warp
Extraction is crossed to obtain.
The extracting method of elm bark polysaccharide described in the cosmetic composition of depigmentaton of the present invention is as follows：
(1) it is crushed after weighing elm bark cleaning, drying；
(2) according to solid-liquid ratio 1:10 ratio is added volume fraction and obtains ethyl alcohol, the water-bath degreasing at 70~75 DEG C for 75%
1h, cooling, filtering, takes filter residue spare；
(3) by filter residue according to solid-liquid ratio 1:15 are added deionized water, and 0.1% complex enzyme is added, and are extracted at 40 DEG C
3h, 95~100 DEG C of enzyme deactivation 15min, it is cooling, it is centrifuged under the conditions of 45000r/min, collection supernatant, Sevage method removing proteins,
It is concentrated under reduced pressure to give elm bark polysaccharide.
Preparing for the rice tunning filtrate is as follows：It weighs rice and water soaked overnight is added, be added suitable white
Sugar and yeast powder, stir, and ferment 3~5d at ambient temperature, and squeezing takes filtrate, are obtained after purification
Rice tunning filtrate.
The preparation method of the Chinese medicine extract is as follows：
(1) Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, the root of Dahurain angelica are proportionally weighed, cleaning, drying respectively crushed 150 mesh, obtain Chinese medicine mixing
Powder；
(2) according to solid-liquid ratio 1:Deionized water is added into Chinese medicine mixed powder and extracts 1~3 time for 10 ratio, every time 1~
5h, Extracting temperature are 45~85 DEG C, and the filtrate extracted every time is merged, and removal of impurities is concentrated to the 1/3~5 of original volume, obtains Chinese medicine
Extracting solution.
And the complex enzyme described in the preparation method step (3) of the elm bark polysaccharide is by cellulase:Pectase
According to 1:2 ratio is mixed to get.
The present invention also provides a kind of application of cosmetic composition of depigmentaton in preparing cosmetics.
A kind of skin whitener of depigmentaton includes the component of following mass percent：The cosmetic composition 10 of above-mentioned depigmentaton
~20%, glycerine 6~12%, arginine 0.1~0.5%, saualane 2~6%, ring five dimethyl silicone polymer 1~10%, different
Hexadecane 1~5%, Polyoxyethylene Sorbitan Monooleate 2~6%, sodium chloride 0.01~0.03%, bisabolol 0.2~0.5%, xylitol
0.1~0.3%, tocopherol acetate 0.1~1%, isopropyl myristate 7~10%, Phenoxyethanol 0.1~0.3%, ethyl
Hexyl glycerine 0.1~0.3%, deionized water surplus.
Following introduction is acted on to the fractions of the present invention：
Elm bark is also known as Siberian elm brak, and main advantageous water, treating stranguria, detumescence and other effects are rich in polysaccharose substance, elm in skin
Bark polysaccharide is made of arabinose, xylose, mannose, galactolipin and mannitol.Elm bark polysaccharide tool is determined in modern study
There is very strong reducing power, and reducing power is obviously incremented by with the increase of mass concentration, research finds to work as elm bark polysaccharide
Mass concentration in 0.6~1.5g/L, the reducing power ratio Vc of elm polysaccharide is higher by 50%70%, show it is very strong also
Proper energy power has inhibition and scavenging effect to a certain extent to hydroxy radical and superoxide radical, can resist as natural
Oxidant uses.
Rice tunning filtrate has the synthesis of collagen in fibroblast and fibroblastic active bacteria
There are facilitation, rice tunning filtrate that can also reduce the formation with pigment, the absorption of skin moisture can be promoted, can maintain
The elasticity of skin makes skin keep smooth delicacy.
Radix Glycyrrhizae contains glycyrrhizic acid and liquiritin, can effectively inhibit the activity of tyrosinase and dopachrome interconvertible enzyme, hinders
The polymerization of 5,6- dihydroxy indoles, the ear-piercing formation for inhibiting melanin, achievees the effect that whitening；Its flavones ingredient energy contained
It is all aobvious to ultraviolet light and visible light due to the conjugacy of liquorice flavonoids compound molecular structure as sun-proof active ingredient
Show strong absorption, absorb high energy UV molecule, from ground state transition to activated state, is then returned to admittedly from activated state
State discharges harmless low energy ray, and skin, stable absorption ability will not be stimulated strong.
The antioxidant contents such as danshinolic acid and Rosmarinic acid that Radix Salviae Miltiorrhizae contains can effectively understand the oxygen radical in human body, suppression
Peroxidatic reaction of lipid processed improves the immunity function of human body, and effect is better than vitamin C, vitamin E, promotes in addition, it also has
Sanguimotor effect can boost metabolism, anti-aging etc..
The root of Dahurain angelica has radioresistance, anti-oxidant, antibacterial skin care activity.
Compared with prior art, the present invention has following advantageous effect：
The cosmetic composition of the depigmentaton of the present invention can have pigment epithelial cell de- keratinization activity, promote to generate
The cell detachment of pigment, and inhibit tyrosinase activity, it reduces melanin and is formed, composition includes elm bark polysaccharide, rice hair
The active constituent of ferment Product filtrate, Chinese medicine extract, wherein elm bark polysaccharide have strong reduction, and can effectively remove certainly
By base；Strong absorption of the Radix Glycyrrhizae to ultraviolet light in Chinese medicine extract, and inhibit tyrosine activity, Radix Salviae Miltiorrhizae promotes skin blood circulation,
Root of Dahurain angelica whitening and skin-protecting；In addition rice tunning filtrate has certain desalination color while promoting the absorption of skin moisture
The whitening effect of element.The present invention applies composition in preparing cosmetics, can assign the whitening of the significant depigmentaton of cosmetics
Effect.Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated：
Embodiment 1
In parts by weight, 6 parts of elm bark polysaccharide, 1 part of rice tunning filtrate, 1 part of Chinese medicine extract, butanediol are weighed
15 parts, 10 parts of deionized water, are prepared the cosmetic composition A of depigmentaton.
Embodiment 2
In parts by weight, 12 parts of elm bark polysaccharide, 20 parts of rice tunning filtrate, 20 parts of Chinese medicine extract, fourth are weighed
30 parts of glycol, 25 parts of deionized water, are prepared the cosmetic composition B of depigmentaton.
Embodiment 3
In parts by weight, 8 parts of elm bark polysaccharide, 10 parts of rice tunning filtrate, 10 parts of Chinese medicine extract, fourth two are weighed
22 parts of alcohol, 18 parts of deionized water, are prepared the cosmetic composition C of depigmentaton.
Embodiment 4
A kind of skin whitener of depigmentaton is prepared by the component of following mass percent：The cosmetics group of above-mentioned depigmentaton
It closes object 10%, glycerine 12%, arginine 0.1%, saualane 6%, ring five dimethyl silicone polymer 1%, isohexadecane 5%, gather
Sorbitol ester -802%, sodium chloride 0.01%, bisabolol 0.2%, xylitol 0.1%, tocopherol acetate 0.1%, Pork and beans
Cool isopropyl propionate 7%, Phenoxyethanol 0.1%, Sensiva SC50 0.1%, deionized water 56.29%.
Embodiment 5
A kind of skin whitener of depigmentaton is prepared by the component of following mass percent：The cosmetics group of above-mentioned depigmentaton
It closes object 15%, glycerine 9%, arginine 0.3%, saualane 4%, ring five dimethyl silicone polymer 5.5%, isohexadecane 3%, gather
Sorbitol ester -804%, sodium chloride 0.02%, bisabolol 0.3%, xylitol 0.2%, tocopherol acetate 0.5%, Pork and beans
Cool isopropyl propionate 8.5%, Phenoxyethanol 0.2%, Sensiva SC50 0.2%, deionized water 49.28%.
Comparative example 1
In parts by weight, 10 parts of rice tunning filtrate, 10 parts of Chinese medicine extract, 22 parts of butanediol, deionization are weighed
The cosmetic composition D of depigmentaton is prepared in 18 parts of water.
Comparative example 2
In parts by weight, 8 parts of elm bark polysaccharide, 10 parts of Chinese medicine extract are weighed, 22 parts of butanediol, 18 parts of deionized water,
The cosmetic composition E of depigmentaton is prepared.
Comparative example 3
In parts by weight, 8 parts of elm bark polysaccharide, 10 parts of rice tunning filtrate, 22 parts of butanediol, deionized water are weighed
18 parts, the cosmetic composition F of depigmentaton is prepared.
Comparative example 4
A kind of skin whitener of depigmentaton is prepared by the component of following mass percent：Glycerine 9%, arginine 0.3%,
Saualane 4%, ring five dimethyl silicone polymer 5.5%, isohexadecane 3%, Polyoxyethylene Sorbitan Monooleate 4%, sodium chloride 0.02%,
Bisabolol 0.3%, xylitol 0.2%, tocopherol acetate 0.5%, isopropyl myristate 8.5%, Phenoxyethanol
0.2%, Sensiva SC50 0.2%, deionized water 64.28%.
Efficacy validation
Free radical scavenging ability is verified
Antioxidant activity is indicated with scavenging ability of DPPH free radical size, according to the condition that preliminary experiment determines, is measured different
Skin whitener sample removes the activity of free radical DPPH.Each 1g of product of Example 1~5, takes each 1g of the sample of comparative example 1~4；
The DPPH ethanol solutions for being separately added into 2.0mL1.52x104mmol/L mix well, after room temperature is protected from light standing 30min, with
Solvent is blank control, and absorbance A 1 is surveyed at 517；Negative control is done instead of sample solution with same volume solvent, measures absorbance
A2；Blank group is done instead of DPPH solution with same volume absolute ethyl alcohol, measures absorbance A 3, it is desirable that 5 repetitions are averaged.
Clearance rate is calculated according to the following formula：
Clearance rate (%)=[1- (A1-A3)/A2] x100% of sample to DPPH
Free radical scavenging activity result record such as the following table 1.
Table 1
| Group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Clearance rate % | 84.6 | 85.7 | 86.9 | 83.7 | 85.5 |
| Group | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Absolute ethyl alcohol |
| Clearance rate % | 44.1 | 47.2 | 49.5 | 18.8 | 6.8 |
By data analysis it is found that the composition of the present invention has significant antioxidant effect, and 1~3 composition of comparative example
It is middle to show poor free radical scavenging activity, illustrate that active constituent is used in compounding because lacking one of active constituent, it sends out
Wave better effect, no added depigmenting compositions in the skin whitener in comparative example 4, antioxidant effect is very poor, and embodiment 4~
5 skin whitener has good antioxidant effect, illustrates that the cosmetic composition addition of depigmentaton can assign in cosmetics
The good effect of scavenging radical of cosmetics.
The effect of in order to further verify product of the present invention, the skin whitener for having chosen embodiment 5 and comparative example 4 carry out human body
Evaluation test on probation.
Experimental program is as follows：Every group of 20 people are selected to test, experimenter uses corresponding product daily, each sample
Time on probation is continuous one month, and at the 30th day, experimenter carried out self-appraisal to the whitening effect of product, it is desirable that experimenter is in reality
Other skin-protection products cannot be used during testing, and all people completes entire experiment, in addition, trier's health is good
It is good, not in nursing period or pregnancy period, complexion jaundice is shown as, or macula lutea point occur.It is detected before the product using the present invention
The pigmentation situation of skin sits the detection of skin pigmentation again after on probation.
As a result 2 be see the table below.
Table 2
By above-mentioned data analysis it is found that the product of the present invention, which has, reduces pigmented effect, lightens the stain, play
The whitening function of pigment, bright color.
Above example is merely to illustrate embodiment of the present invention, and there is no have limit in any form to the present invention
System；It is any to be engaged in professional and technical personnel, it all has the ability, using the technology contents having revealed that, to make it some and change or repair
Decorations, become the equivalent embodiment of equivalent variations.According to the technology of the present invention essence, simply modification, equivalent variations are carried out to the present invention
With modification, belong in the range of technical solution of the present invention.
Claims (10)
1. a kind of cosmetic composition of depigmentaton, which is characterized in that its active constituent includes the component of following parts by weight：Elm
6~12 parts of skin polysaccharide, 1~20 part of rice tunning filtrate, 1~20 part of Chinese medicine extract.
2. the cosmetic composition of depigmentaton according to claim 1, which is characterized in that the cosmetics group of the depigmentaton
It further includes 15~30 parts of butanediol, 10~25 parts of deionized water to close object.
3. the cosmetic composition of depigmentaton according to claim 2, which is characterized in that in parts by weight, the group
It includes 8 parts of elm bark polysaccharide, 10 parts of rice tunning filtrate, 10 parts of Chinese medicine extract, 22 parts of butanediol, deionized water to close object
18 parts.
4. the cosmetic composition of depigmentaton according to claim 3, which is characterized in that the Chinese medicine extract is by sweet
Grass, Radix Salviae Miltiorrhizae, the root of Dahurain angelica are according to 1:1~3:1~2 ratio mixing, obtains by extraction.
5. the cosmetic composition of depigmentaton according to claim 3, which is characterized in that the elm bark polysaccharide carries
Take method as follows：
(1) it is crushed after weighing elm bark cleaning, drying；
(2) according to solid-liquid ratio 1:10 ratio is added volume fraction and obtains ethyl alcohol for 75%, and water-bath degreasing 1h, cold at 70~75 DEG C
But it, filters, takes filter residue spare；
(3) by filter residue according to solid-liquid ratio 1:15 are added deionized waters, and 0.1% complex enzyme is added, and extract 3h at 40 DEG C, and 95
~100 DEG C of enzyme deactivation 15min, it is cooling, it is centrifuged under the conditions of 45000r/min, collects supernatant, Sevage method removing proteins depressurize dense
Contracting obtains elm bark polysaccharide.
6. the cosmetic composition of depigmentaton according to claim 3, which is characterized in that the rice tunning filter
Preparing for liquid is as follows：It weighs rice and water soaked overnight is added, suitable white sugar and yeast powder is added, stirs, in room
Ferment 3~5d under the conditions of temperature, and squeezing takes filtrate, and rice tunning filtrate is obtained after purification.
7. the cosmetic composition of depigmentaton according to claim 3, which is characterized in that the system of the Chinese medicine extract
Preparation Method is as follows：
(1) Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, the root of Dahurain angelica are proportionally weighed, cleaning, drying respectively crushed 150 mesh, obtain Chinese medicine mixed powder；
(2) according to solid-liquid ratio 1:Deionized water is added into Chinese medicine mixed powder and extracts 1~3 time for 10 ratio, and 1~5h, carries every time
It is 45~85 DEG C to take temperature, and the filtrate extracted every time is merged, and removal of impurities is concentrated to the 1/3~5 of original volume, obtains traditional Chinese medicine extraction
Liquid.
8. the preparation method of elm bark polysaccharide according to claim 5, which is characterized in that compound described in step (3)
Enzyme is by cellulase:Pectase is according to 1:2 ratio is mixed to get.
9. according to application of the cosmetic composition of claim 1~7 any one of them depigmentaton in preparing cosmetics.
10. a kind of skin whitener of depigmentaton, which is characterized in that include the component of following mass percent：The change of above-mentioned depigmentaton
Cosmetic compositions 10~20%, glycerine 6~12%, arginine 0.1~0.5%, saualane 2~6%, five polydimethylsiloxanes of ring
Alkane 1~10%, isohexadecane 1~5%, Polyoxyethylene Sorbitan Monooleate 2~6%, sodium chloride 0.01~0.03%, bisabolol 0.2~
0.5%, xylitol 0.1~0.3%, tocopherol acetate 0.1~1%, isopropyl myristate 7~10%, Phenoxyethanol 0.1
~0.3%, Sensiva SC50 0.1~0.3%, deionized water surplus.
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| CN201810358982.XA CN108420772A (en) | 2018-04-19 | 2018-04-19 | A kind of cosmetic composition of depigmentaton and its application |
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| CN201810358982.XA CN108420772A (en) | 2018-04-19 | 2018-04-19 | A kind of cosmetic composition of depigmentaton and its application |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599020A (en) * | 2013-09-06 | 2014-02-26 | 芽美化妆品有限公司 | Skin whitening cosmetic composition |
| CN105193658A (en) * | 2015-09-30 | 2015-12-30 | 上海全丽生物科技有限公司 | Cosmetic with fermented original rice milk, method for manufacturing cosmetic and application thereof |
-
2018
- 2018-04-19 CN CN201810358982.XA patent/CN108420772A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599020A (en) * | 2013-09-06 | 2014-02-26 | 芽美化妆品有限公司 | Skin whitening cosmetic composition |
| CN105193658A (en) * | 2015-09-30 | 2015-12-30 | 上海全丽生物科技有限公司 | Cosmetic with fermented original rice milk, method for manufacturing cosmetic and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 魏征，等: ""复合酶辅助热水浸提法提取榆树皮多糖工艺研究"", 《中国酿造》 * |
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Application publication date: 20180821 |