CN108420752A - A kind of facial mask and preparation method thereof containing stem cell factor - Google Patents
A kind of facial mask and preparation method thereof containing stem cell factor Download PDFInfo
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- CN108420752A CN108420752A CN201810570014.5A CN201810570014A CN108420752A CN 108420752 A CN108420752 A CN 108420752A CN 201810570014 A CN201810570014 A CN 201810570014A CN 108420752 A CN108420752 A CN 108420752A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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Abstract
The invention discloses a kind of facial masks containing stem cell factor, are calculated by mass percentage, contain following components：0.1~20 part of hyaluronic acid, 0.1~10.0 part of skin whitening agent, 2.0~20.0 parts of emulsifier, 0.5~20.0 part of keratolytic, 1.0~15.0 parts of external skin wrinkling-preventing agent, 0.1~5.0 part of aromatic, 0.1~10.0 part of stem cell factor, surplus is water.Contain stem cell factor in the mask composition of the present invention, be entirely free of preservative, artificial color, essence and flavoring agent, mineral oil etc. there are dysgenic chemical components to skin, and the raw material in facial mask is substantially all to be extracted from nature, safe and non-stimulating.Facial mask obtained can keep skin moisturizing glossy with beautifying face and moistering lotion, and with removal face wrinkles and skin whitening, moisturizing and other effects, and preparation method is simple, has very good application prospect.
Description
Technical field
The present invention relates to skin care field, specially a kind of facial mask and preparation method thereof containing stem cell factor.
Background technology
Facial mask is a kind of currently used cosmetology product, and principle was passed through using the of short duration time for being covered in face
It is temporarily isolating extraneous air and pollution, improves skin temperature, the pore expansion of skin promotes sweat gland secretion and metabolism,
So that the oxygen content of skin is increased, is conducive to the oil substances that skin excludes the product and accumulation of epidermal cell metabolism, face
Moisture content in film penetrates into the cuticula of skin epidermis, and skin becomes soft, and skin is naturally bright with elasticity, reaches beautifying and anti-aging
Effect.Facial mask type on domestic market is very more, the various composition in facial mask, such as hyaluronic acid, superoxides discrimination
Change enzyme, the substances such as fibroblast growth factor impart facial mask whitening antioxygen, moisturizing moisturizing, Firm are crease-resistant, sensitive skin, U.S.
White moisturizing, moisturizing isolation and other effects, thus liked by numerous people seeking beauties.
Porcine HGF plays physiological regulatory action to various kinds of cell physiological function and metabolic activity, they are in vivo
Content is atomic, but bioactivity is high.In beauty and skin care, plastic surgery, burn ulcer and various dermopathic wound reparations
It plays an important role with healing.Porcine HGF is the optimum activity ingredient of skin nursing, and it is old can to control or regulate skin
Change process protects damaged skin, delay skin aging, to keeping the structure and function of normal skin, maintaining the normal life of body
Reason activity and metabolism are of great significance.Caused by the factors such as age, physiology, environment during skin aging, skin is lived
Property reduce, physiological function decline, it is serious also pathology to be caused to sexually revise.In the form of molecule or pass through special transmission system
(liposome, package liposome, microballoon), Porcine HGF is added in facial cleanser, gel, essence or lotion, to declining
Old skin plays important Molecular biological function.
Since the last century 80's, skin expert finds that, various natural materials is added in skin care item, to skin
There is good nourishing effect, and have no toxic side effect, is especially added in skin care item more from effective component extracting in natural materials
Has remarkable effect.Therefore, develop a kind of be made using the active ingredient extracted from natural materials has nutrition to human skin
It is just of great significance to the beauty and skin care cosmetics of protective effect.
Invention content
The technical problem to be solved by the present invention is to overcome the existing defects, provides a kind of facial mask containing stem cell factor
Preparation method, be calculated by mass percentage, formula contain following components：
0.1~20.0 part of hyaluronic acid, 0.1~10.0 part of skin whitening agent, 2.0~20.0 parts of emulsifier, angle
0.5~20.0 part of matter softening agent, 1.0~15.0 parts of external skin wrinkling-preventing agent, 0.1~5.0 part of aromatic, stem cell factor 0.1
~10.0 parts, surplus is water.
Further, it is calculated by mass percentage, formula contains following components：
1.0~3.5 parts of hyaluronic acid, 2.5~5 parts of skin whitening agent, 8~12 parts of emulsifier, keratolytic 1
~4 parts, 3~5 parts of external skin wrinkling-preventing agent, 0.1~5 part of aromatic, 2~4 parts of stem cell factor, surplus is water.
Further, the hyaluronic acid refers to hyaluronic acid and fibroblast growth factor, epithelial growth
One in the factor, vascular endothelial growth factor, superoxide dismutase, palmityl tetrapeptide, palmitic acid SymPeptide, acetyl group hexapeptide
Kind or several conjugation are bonded and obtain, and hyaluronan molecule amount selection is easy to the ＜ 50KDa's absorbed by human epidermal
Micromolecule hyaluronic acid
Further, a kind of facial mask containing stem cell factor, the skin whitening agent be vitamin C,
Any one or a few in Seabuckthorn Oil, tartaric acid, ascorbic acid, gallic acid, kojic acid, vitamin B3.
Further, the keratolytic lanolin, it is sunflower oil, grape seed oil, safflower oil, evening primrose oil, molten
Solve any one or a few in keratinase.
Further, the external skin wrinkling-preventing agent be niacin, niacinamide, D~pantothenic acid, in vitamin E any one or
It is several.
Further, the aromatic is salvia officianlis oil, Rosa Damascana, chamomile essential oil, Lavender, bergamot
Any one or a few in essential oil, lemon, Peppermint essential oil.
Further, the preparation method of the hyaluronic acid, to be 10,000 by 3.0~5.0g molecular weight
~30,000 hyaluronic acid is dissolved in 80~100ml PBS buffer solutions, and it is 7.0~8.0 to adjust pH, and 100~400mg is added
The polypeptide of sodium metaperiodate open loop and 100~200mg, conjugation condensation reaction 8 hours, it is ensured that the reaction was complete；Gel chromatography after purification,
Freeze-drying, nuclear magnetic resonance confirm.
The preparation method of the facial mask containing stem cell factor, includes the following steps：
By 0.1~20 part of hyaluronic acid, 0.1~10 part of skin whitening agent, 2~20 parts of emulsifier, cutin softening
0.5~20 part of agent is added in ultra-pure water, and 40~50 DEG C stir evenly, spare；
(2) 1~15 part of external skin wrinkling-preventing agent, 0.1~5 part of aromatic, 0.1~10 part of stem cell factor are uniformly mixed,
It is spare；
(3) it is added in the mixture that step (2) obtains, stirs when the mixture obtained by step (1) being cooled to 35 DEG C
Uniformly；
(4) ultra-pure water is added in the mixture obtained to step (3), until mixture gross mass is 100 parts.
The beneficial effects of the invention are as follows：
Contain stem cell factor in the mask composition of the present invention, it is fragrant to be entirely free of preservative, artificial color, essence
Material, mineral oil etc. have dysgenic chemical components to skin, and the raw material in facial mask is substantially all to be extracted from nature, safety
It is non-stimulated.Facial mask obtained can keep skin moisturizing glossy with beautifying face and moistering lotion, and with removal face wrinkles and skin whitening, moisturizing
And other effects, and preparation method is simple, has a very good application prospect, the water-retaining property of hyaluronic acid and its can penetrate into very
Skin has mild dilation capillary, increases blood circulation, improves intermediate supersession, promotes skin-nourishing absorption, Ke Yida
To stronger wrinkle-chasing function, to increase skin elasticity, and then the beauty functions of delay skin aging.Hyaluronic acid and albumen or
The facial mask that person's polypeptide peptide key compound makes is stablized relatively, is released in use by face's skin by reversible chemical bond
Skin absorbs, long action time, and cosmetic result is apparent.
Specific implementation mode
Hereinafter, preferred embodiments of the present invention will be described, it should be understood that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Embodiment 1
A kind of facial mask containing stem cell factor, is calculated by mass percentage, contains following components：
0.1 part of hyaluronic acid and superoxide dismutase key compound, 10.0 parts of vitamin C agent, 2.0 parts of emulsifier, wool
0.5 part of fat, 1.0 parts of niacin, 5.0 parts of salvia officianlis oil, 10.0 parts of stem cell factor, surplus is water.
Embodiment 2
A kind of facial mask containing stem cell factor, is calculated by mass percentage, contains following components：
20.0 parts of hyaluronic acid and palmityl tetrapeptide key compound, 0.1 part of Seabuckthorn Oil, 20.0 parts of emulsifier, sunflower oil
20.0 parts, 15.0 parts of niacinamide, 0.1 part of Rosa Damascana, 0.1 part of stem cell factor, surplus is water.
Embodiment 3
A kind of facial mask containing stem cell factor, is calculated by mass percentage, contains following components：
10.0 parts of hyaluronic acid and vascular endothelial growth factor key compound, 5.0 parts of tartaric acid, 11.0 parts of emulsifier, grape pip
10.5 parts of oil, 8.0 parts of D~pantothenic acid, 2.5 parts of chamomile essential oil, 5.0 parts of stem cell factor, surplus is water.The facial mask has
Improve the function of the anti-red blood silk of microcirculation.
Wherein, the preparation process of hyaluronic acid and the key compound of vascular endothelial growth factor is：
The hyaluronic acid that 3.0g molecular weight is 30,000 is dissolved in 80ml PBS buffer solutions (2%, w/v), pH is adjusted
It is 7.0,200mg sodium metaperiodate open loops is added, the vascular endothelial growth factor of 100mg is added, is conjugated condensation reaction 8 hours, really
The reaction was complete by guarantor；After purification, freeze-drying, nuclear magnetic resonance confirms gel chromatography.
The preparation method of the hyaluronic acid vascular endothelial growth factor key compound facial mask, includes the following steps：
By 10.0 parts of hyaluronic acid and vascular endothelial growth factor key compound, 5.0 parts of tartaric acid, 11.0 parts of emulsifier, grape
10.5 parts of seed oil, is added in ultra-pure water, 40~50 DEG C stir evenly, spare；
(2) 8.0 parts of D~pantothenic acid, 2.5 parts of chamomile essential oil, 5.0 parts of stem cell factor are uniformly mixed, spare；
(3) it is added in the mixture that step (2) obtains, stirs when the mixture obtained by step (1) being cooled to 35 DEG C
Uniformly；
(4) ultra-pure water is added in the mixture obtained to step (3), until mixture gross mass is 100 parts.
Embodiment 4
A kind of facial mask containing stem cell factor, is calculated by mass percentage, contains following components：
2.0 parts of hyaluronic acid and acid fibroblast growth factor key compound, 2.5 parts of ascorbic acid, 8 parts of emulsifier,
1 part of safflower oil, 3 parts of vitamin E, 0.1 part of Lavender, 2 parts of stem cell factor, surplus is water.The facial mask is a kind of
Facial mask with deep layer repair function.
Wherein, the preparation process of hyaluronic acid and acid fibroblast growth factor key compound is：
The hyaluronic acid that 3.5g molecular weight is 20,000 is dissolved in 90ml PBS buffer solutions (2%, w/v), pH is adjusted
It is 7.2,400mg sodium metaperiodate open loops is added, the acid fibroblast growth factor of 200mg is added, conjugation condensation reaction 8 is small
When, it is ensured that the reaction was complete；After purification, freeze-drying, nuclear magnetic resonance confirms gel chromatography.
The preparation method of hyaluronic acid and acid fibroblast growth factor key compound facial mask, includes the following steps：
(1) 2.0 parts of hyaluronic acid and acid fibroblast growth factor key compound, 2.5 parts of ascorbic acid, emulsifier 8
Part, 1 part of safflower oil is added in ultra-pure water, and 40~50 DEG C stir evenly, spare；
(2) 3 parts of vitamin E, 0.1 part of Lavender, 2 parts of stem cell factor are uniformly mixed, spare；
(3) it is added in the mixture that step (2) obtains, stirs when the mixture obtained by step (1) being cooled to 35 DEG C
Uniformly；
(4) ultra-pure water is added in the mixture obtained to step (3), until mixture gross mass is 100 parts.
Embodiment 5
A kind of facial mask containing stem cell factor, is calculated by mass percentage, contains following components：
3.5 parts of hyaluronic acid and epidermal growth factor key compound, 5g parts of gallic acid, 12 parts of emulsifier, evening primrose oil 4
Part, 5 parts of vitamin E, 5 parts of Bergamot, 4 parts of stem cell factor, surplus is water.There is the facial mask anti-acne to repair work(
Energy.
Wherein, the preparation process of hyaluronic acid and epidermal growth factor key compound is：
The hyaluronic acid that 4g molecular weight is 10,000 is dissolved in 100ml PBS buffer solutions (2%, w/v), adjusting pH is
7.5,400mg sodium metaperiodate open loops are added, the epidermal growth factor of 200mg, conjugation condensation reaction 8 hours, it is ensured that reaction is added
Completely；After purification, freeze-drying, nuclear magnetic resonance confirms gel chromatography.
Embodiment 6
A kind of facial mask containing stem cell factor, is calculated by mass percentage, contains following components：
3 parts of hyaluronic acid and palmitic acid SymPeptide key compound, 4 parts of kojic acid, 8 parts of emulsifier dissolve 1~4 part of keratinase,
3 parts of niacinamide, 2 parts of lemon, 2 parts of stem cell factor, surplus is water.A kind of facial mask anti-wrinkle face mask in fact.
Wherein, the preparation process of hyaluronic acid and palmitic acid SymPeptide key compound is：
The hyaluronic acid that 5.0g molecular weight is 25,000 is dissolved in 85ml PBS buffer solutions (2%, w/v), pH is adjusted
It is 7.5,200mg sodium metaperiodate open loops is added, the palmitic acid SymPeptide key compound of 175mg is added, is conjugated condensation reaction 8 hours,
Ensure that the reaction was complete；After purification, freeze-drying, nuclear magnetic resonance confirms gel chromatography.
Embodiment 7
A kind of facial mask containing stem cell factor, is calculated by mass percentage, contains following components：
1.0 parts of hyaluronic acid and acetyl group hexapeptide key compound, 2.5 parts of vitamin B3,9 parts of dissolving keratinases 3 of emulsifier
Part, 4 parts of D~pantothenic acid, 2 parts of Peppermint essential oil, 4 parts of stem cell factor, surplus is water.
Embodiment 8
A kind of facial mask containing stem cell factor, is calculated by mass percentage, contains following components：
Hyaluronic acid and more 5.0 parts of palmityl tetrapeptide key compounds, 2.5 parts of vitamin C, 10 parts of emulsifier, keratolytic
2 parts, 4 parts of vitamin E, 2 parts of Rosa Damascana, 2 parts of stem cell factor, surplus is water.
Finally it should be noted that：The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
With technical scheme described in the above embodiments is modified or equivalent replacement of some of the technical features.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in the present invention's
Within protection domain.
Claims (9)
1. a kind of facial mask containing stem cell factor, which is characterized in that be calculated by mass percentage, contain following components：
0.1~20 part of hyaluronic acid, 0.1~10.0 part of skin whitening agent, 2.0~20.0 parts of emulsifier, cutin softening
0.5~20.0 part of agent, 1.0~15.0 parts of external skin wrinkling-preventing agent, 0.1~5.0 part of aromatic, stem cell factor 0.1~10.0
Part, surplus is water.
2. a kind of facial mask containing stem cell factor as described in claim 1, which is characterized in that by mass percentage
It calculates, contains following components：
1.0~5.0 parts of hyaluronic acid, 2.5~5 parts of skin whitening agent, 8~12 parts of emulsifier, keratolytic 1~4
Part, 3~5 parts of external skin wrinkling-preventing agent, 0.1~5 part of aromatic, 2~4 parts of stem cell factor, surplus is water.
3. a kind of facial mask containing stem cell factor as claimed in claim 1 or 2, which is characterized in that the hyalomitome
Sour compound refers to hyaluronic acid and fibroblast growth factor, epidermal growth factor, vascular endothelial growth factor, superoxides
One or more of mutase, palmityl tetrapeptide, palmitic acid SymPeptide, acetyl group hexapeptide conjugation are bonded and obtain, and described is saturating
Bright matter acid molecule amount is less than 50KDa.
4. a kind of facial mask containing stem cell factor as claimed in claim 1 or 2, which is characterized in that the skin is beautiful
White agent is any one or a few in vitamin C, Seabuckthorn Oil, tartaric acid, ascorbic acid, gallic acid, kojic acid, vitamin B3.
5. a kind of facial mask containing stem cell factor as claimed in claim 1 or 2, which is characterized in that the cutin is soft
Agent lanolin, sunflower oil, grape seed oil, safflower oil, evening primrose oil, dissolving keratinase in any one or a few.
6. a kind of facial mask containing stem cell factor as claimed in claim 1 or 2, which is characterized in that the skin is anti-
Wrinkle agent is any one or a few in niacin, niacinamide, D~pantothenic acid, vitamin E.
7. a kind of facial mask containing stem cell factor as claimed in claim 1 or 2, which is characterized in that the aromatic
For appointing in salvia officianlis oil, Rosa Damascana, chamomile essential oil, Lavender, Bergamot, lemon, Peppermint essential oil
Meaning is one or more of.
8. a kind of facial mask containing stem cell factor as described in claim 1, which is characterized in that the hyaluronic acid is multiple
The preparation method for closing object is that it is slow that the hyaluronic acid that 3~5g molecular weight is 10,000~30,000 is dissolved in 80~100mlPBS
It rushes in solution, it is 7.0~8.0 to adjust pH, and the polypeptide of the open loop of 100~400mg sodium metaperiodates and 100~200mg, conjugation contracting is added
Close reaction 8 hours, it is ensured that the reaction was complete；After purification, freeze-drying, nuclear magnetic resonance confirms gel chromatography.
9. a kind of preparation method of the facial mask containing stem cell factor, which is characterized in that include the following steps：
0.1~20 part of hyaluronic acid, 0.1~10.0 part of skin whitening agent, 2.0~20.0 parts of emulsifier, cutin softening
0.5~20.0 part of agent is added in ultra-pure water, is stirred evenly at 40~50 DEG C, spare；
(2) 1.0~15 parts of external skin wrinkling-preventing agent, 0.1~5 part of aromatic, 0.1~10 part of stem cell factor are uniformly mixed, standby
With；
(3) mixture obtained by step (1) is cooled to 35 DEG C, is added in the mixture that step (2) obtains, stirs evenly；
(4) ultra-pure water is added in the mixture obtained to step (3), until mixture gross mass is 100 parts.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810570014.5A CN108420752A (en) | 2018-06-05 | 2018-06-05 | A kind of facial mask and preparation method thereof containing stem cell factor |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810570014.5A CN108420752A (en) | 2018-06-05 | 2018-06-05 | A kind of facial mask and preparation method thereof containing stem cell factor |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109718195A (en) * | 2019-03-15 | 2019-05-07 | 上海市东方医院（同济大学附属东方医院） | Facial mask liquid containing stem cell factor |
| CN110151671A (en) * | 2019-07-10 | 2019-08-23 | 北京迪斯菲丽生物科技有限公司 | A kind of cell Essence and its store method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109718195A (en) * | 2019-03-15 | 2019-05-07 | 上海市东方医院（同济大学附属东方医院） | Facial mask liquid containing stem cell factor |
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Application publication date: 20180821 |