CN108403877A - A kind of Chinese medicine composition and preparation method thereof that there is weight-reducing, improve sleep - Google Patents
A kind of Chinese medicine composition and preparation method thereof that there is weight-reducing, improve sleep Download PDFInfo
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The present invention discloses a kind of Chinese medicine composition and preparation method thereof for having weight-reducing, improving sleep, belongs to technical field of Chinese medicine.The present composition be aqueous extract and the mushroom of following bulk pharmaceutical chemicals, needle mushroom parent species liquid carry out product obtained by common fermentation；The bulk pharmaceutical chemicals have following weight：10 25 parts of campanulaceae, 15 25 parts of purslane, 5 15 parts of mulberry fruit, 15 28 parts of oyster, 15 30 parts of beauty Jiao Gen, 80~100 parts by weight of balsam pear, 35 parts of lotus leaf, 50 80 grams of pigskin, 70 150 parts of seaweed, 10 20 parts of luffa.Chinese medicine composition provided by the invention with weight-reducing, improvement sleep is notable with therapeutic effect, and cure rate is high, the characteristics of having no toxic side effect.
Description
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to a kind of Chinese medicine composition for having weight-reducing, improving sleep.
Background technology
Modern allegro life and gradually violent various competitive relations, keep people's stress increasing, spirit
Long-term nervous and a series of irregular rhythm of life, the obesity caused and insomnia annoying always most people.According to system
Meter, the insomniac in China are the 20%~30% of total population, and the wherein middle-aged and the old accounts for about 70%.Chronic insomnia and obesity easily cause
Vexed easy unrest, fatigue and weak, or even with headache, dreaminess, hidrosis, failure of memory, can also cause a series of clinical symptoms, and lure
Send out some psychosomatic diseases.The reduction for leading to working efficiency because of body slight illness, makes insomniac's psychological pressure increase, so pernicious
Cycle occurs neurasthenia, endocrine disorder etc., or even is developed to mental disease to more serious direction.
So the pharmaceutical requirements for the treatment of insomnia increase, the drug for treating insomnia is also invented and is produced with various states.So
And not only effect cannot be affirmed these drugs mostly, also, hypnotic be mostly in vivo by liver, renal metabolism,
The burden of liver kidney can be increased by taking for a long time, and some can also cause liver enlargement, hepatalgia, jaundice, edema, albuminuria, blood urine
And the liver and kidney dysfunctions such as nausea, abdominal distension, loss of appetite, constipation and stomach react and aggravate obesity.Some hypnotics can also be led
Lassitude, hypophrenia, the accumulation of poisoning symptom such as blood pressure decline are caused, or even causes respiratory and circulatory function obstacle situation.Therefore,
Class drug is stabilized in the elderly's application more should be careful.
Therefore it provides Small side effects, and improvement sleep, fat-reducing effect significantly have great importance.
Invention content
Therefore, the technical problem to be solved in the present invention is to overcome drug in the prior art for insomnia and fat pair
Big defect is acted on, to provide a kind of Chinese medicine composition and preparation method thereof that there is weight-reducing, improve sleep.
For this purpose, the present invention provides the following technical solutions：
A kind of Chinese medicine composition for having weight-reducing, improving sleep is the aqueous extract and mushroom, needle mushroom of following bulk pharmaceutical chemicals
Parent species liquid carry out common fermentation obtained by product；
The bulk pharmaceutical chemicals have following weight：10-25 parts of campanulaceae, 15-25 parts of purslane, 5-15 parts of mulberry fruit,
15-28 parts of oyster, 15-30 parts of beauty Jiao Gen, 80~100 parts by weight of balsam pear, 3-5 parts of lotus leaf, 50-80 grams of pigskin, seaweed 70-
150 parts, 10-20 parts of luffa.
The aqueous extract of the bulk pharmaceutical chemicals is to use hydrogen-rich water for Extraction solvent, it is preferable that the hydrogen-rich water is day Tian Tian
Inland waters.
The Chinese medicine composition：Selected from following any group of weight：
10 parts of campanulaceae, 20 parts of purslane, 13 parts of mulberry fruit, 17 parts of oyster, 21 parts of beauty Jiao Gen, 80 parts by weight of balsam pear, lotus
5 parts of leaf, 61 grams of pigskin, 150 parts of seaweed, 20 parts of luffa；
25 parts of campanulaceae, 15 parts of purslane, 9 parts of mulberry fruit, 22 parts of oyster, 15 parts of beauty Jiao Gen, 95 parts by weight of balsam pear, lotus leaf
4 parts, 80 grams of pigskin, 70 parts of seaweed, 10 parts of luffa；
13 parts of campanulaceae, 18 parts of purslane, 15 parts of mulberry fruit, 15 parts of oyster, 15-30 parts of beauty Jiao Gen, 105 weight of balsam pear
Part, 3 parts of lotus leaf, 50 grams of pigskin, 80 parts of seaweed, 13 parts of luffa；
20 parts of campanulaceae, 25 parts of purslane, 5 parts of mulberry fruit, 28 parts of oyster, 30 parts of beauty Jiao Gen, 85 parts by weight of balsam pear, lotus leaf
5 parts, 72 grams of pigskin, 130 parts of seaweed, 17 parts of luffa.
The mushroom parent species liquid and the needle mushroom parent species liquid are that the solution prepared with 20L hydrogen-rich waters and auxiliary material connects
Obtained by kind test tube stock culture；
The weight of the raw material of the auxiliary material is：Magnesium sulfate 20g, dipotassium hydrogen phosphate 45g, potassium dihydrogen phosphate 52g, sugarcane
Sugared 250g, starch 240g.
Include the product of the Chinese medicine composition that there is weight-reducing, improve sleep.
The preparation method of the Chinese medicine composition for having weight-reducing, improving sleep, includes the following steps：
(1) aqueous extract of bulk pharmaceutical chemicals is prepared；
(2) aqueous extract of bulk pharmaceutical chemicals carries out common fermentation with mushroom parent species liquid, needle mushroom parent species liquid and obtains tunning；
The extraction process of the aqueous extract of the bulk pharmaceutical chemicals is as follows：In extraction vessel, water and bulk pharmaceutical chemicals are added；Water and institute
It is 3-6 to state bulk pharmaceutical chemicals weight ratio:1, it is extracted 30-50 minutes under 25-35 DEG C, 800mpa environment and obtains the water of the bulk pharmaceutical chemicals
Extracting solution.
The progress common fermentation refers in fermentation tank, by 30-50:30-50:5-10:Described in the volume ratio of 5-10 is added
The aqueous extract of bulk pharmaceutical chemicals, the parent species liquid of water, mushroom parent species liquid, needle mushroom.
The water uses hydrogen-rich water.
The fermentation refers to that fermentation puts tank when reaching 80g/L to effective solid contents.
Multiple components are played altogether in the Chinese medicine used in the oral products of the present invention strengthens the body resistance to consolidate the constitution, the gas of strong completion body, shield
The effect of liver, kidney and angiocarpy, raising immunity, lowering blood-fat and reducing weight, happy body and mind, is conducive to prevention and treatment insomnia and obesity
And its various symptoms of complication.The bulk pharmaceutical chemicals pharmacology of use is as follows：
Mulberry fruit：Also known as black mulberry, civil and military real, black mulberry, mulberry jujube, mulberries, sorosis.It is sweet in flavor, sour, it is cold in nature, return liver and kidney channel.
Major function：Nourishing yin and nourishing blood promotes the production of body fluid, ease constipation.Cure mainly that kidney deficiency and liver and deficiency of blood essence lose has a dizzy spell；Soreness of waist tinnitus；Beard and hair is early
In vain；Insomnia and dreamful sleep；Injury thirst；It quenches one's thirst；Dry constipation of intestines.Usage and dosage：It is for oral administration：Decoction, 10~30g；Or cream, infusing drugs in wine, life
It eats；Or enters nine, dissipates.External application：In right amount, immersion is washed.
Purslane：For the herb of Portulacaceae portulaca purslane；Contain a large amount of norepinephrines and volume
Sylvite (including potassium nitrate, potassium chloride, potassium sulfate and other sylvite) also contains DOPA, dopamine, betanidin, isobetanidin, sweet tea
Dish glycosides etc., amino acids such as glutamic acid, aspartic acid, alanine, polysaccharide and other multiple active components；Nature and flavor acid, it is cold, return large intestine,
Liver Channel；It can heat-clearing, removing toxic substances, cool blood, detumescence；Cure mainly heat toxin rush down dysentery, heat gonorrhea blood strangury, erysipelas scrofula etc.；Modern pharmacology proves horse
Bitterroot has the effects that antibacterial, reducing blood lipid, antiatherosclerosis.
Luffa：It is sweet, flat.Return lung, stomach, Liver Channel.Dispelling wind and removing obstruction in the meridians, resolving sputum of detoxifying.For arthralgia pain due to rheumatism, the obstruction of qi in the chest, chest and hypochondrium
Deng.
Seaweed：For Sargassaceae plant Sargassum or the drying frond of sargassum fusifome.Algae,【Nature and flavor】It is bitter, salty, it trembles with fear.【Channel tropism】
Return liver, stomach, kidney channel.【Major function】Softening and resolving hard mass, dissolving phlegm, Li Shui.For goiter and tumor, scrofula, testiclar gall, phlegm and retained fluid oedema.
Oyster：It is salty, it is slightly cold, Return liver, courage, kidney channel；Function nourishing and suppressing Yang, arrest sweating astringent method, softening and resolving hard mass cure mainly in the deficiency of Yin
Heat, abnormal sweating, involuntary emission, under, diarrhea, soft bone disease.
Pigskin：It is sweet in flavor, cool in nature, there are enriching yin qi-restoratives, the work(of clearing heat, relieving sore-throat to make.《Compendium of Materia Medica》:Control few cloudy lower profit, pharyngalgia.
《Changsha medicine solution》:Pig skin throats and pain of subsiding a swelling, clear away heart-fire lung and remove dysphoria.Pig skin is good at clearing lung-heat, normal lung-QI drop, and floating fire returns root,
Then pharyngalgia and dysphoria are certainly flat.
Campanulaceae is the root of dicotyledon Campanulaceae campanulaceae (Platycodongrandiflorum (Jacq.) A.DC.).
Bitter, pungent, slightly warm in nature.Enter lung channel.Energy expelling phlegm and arresting coughing, and have facilitaing lung, apocenosis effect.Pharmacological research shows campanulaceae decoction
Anesthesia dog gavage is given with 1g/kg, respiratory secretions can be made to increase；Platycodoside crude product have calm, analgesia and it is antipyretic etc. in
Pivot inhibiting effect.Borrow the inhibiting effect of its Central nervous with sleeping in the drug of the present invention.
Beauty Jiao Gen has clearing heat and detoxicating, menstruation regulating, Li Shui and other effects；For treat acute icteric catarrhal jaundice, long
The diseases such as dysentery, spitting of blood, metrorrhagia, leukorrhea, irregular menstruation, sore carbuncle swells.Chinese sumac root contains 3,7,4'- trihydroxyflavones, 3,7,3',
4'- kaempferols, scopoletin, gallic acid, progallin A, Indian beech flavine, tetramethoxy
The small Calusena lansium essence of fisetin, de-methoxy, dibenzoyl methane, oval leaf precipice beans rattan ketone, Quercetin, cupreol, have wind-dispelling
Dehumidifying, inducing diuresis for removing edema, Huoxue San " poison and other effects；For treating arthralgia pain due to rheumatism, oedema, cough, treating swelling and pain by traumatic injury, acute mastitis, tinea sore etc.
Disease.Paulownia root has wind-expelling pain-stopping, removing toxic substances promoting blood circulation and other effects；For treating rheumatism gesture numbness, arthralgia and myalgia, sore swollen toxin, bruise
The diseases such as damage.
Lotus leaf, pharmacological property is bitter, puckery, puts down.The thoughts of returning home, liver, the spleen channel.With clearing away summerheat, the effect of rising Yang, hemostasis.Heat can be treated
Hot polydipsia, dizziness of having a headache, splenasthenic abdominal distention, stool diarrhea, lower blood of spitting blood, post partum longtime lochia, red trip erysipelas etc..(《The big diction of Chinese medicine
Allusion quotation》The Shanghai science tech publishing house second edition page 2510 is write by Nanjing University of Traditional Chinese Medicine).《Compendium of Materia Medica》It carries：" lotus leaf takes
It, makes us thin bad, single gas for taking the yang edema edema that can disappear ".This Chinese medicine composition mainly uses it as weight-reducing main ingredient.
Balsam pear (Momordica charantia) belongs to Curcurbitaceae and known with the name of balsam pear, and fruit contains balsam pear
Glucoside (Charantin) polypeptide etc. has the function of fat eliminating weight-reducing.
Mushroom：Lentinus edodes (Berk.) sing, be Pleurotaceae plant mushroom, rich in vitamin B complex, iron, potassium,
Provitamin D (vitamin D is changed into after solarization), sweet in flavor, mild-natured, Quantitative Determination of Ergosterol is very high in mushroom, to preventing rickets
Effectively；Lentinan (β~1,3 glucans) can enhance cell immunocompetent；Mushroom contains more than 40 kinds of enzyme of six big enzymes, can be with
Correct human chitinase deficiency disease；It is beneficial to reduce blood fat to human body for fatty institute's fatty acids in mushroom.
Needle mushroom：Name hair handle money bacterium, also known as hair handle small fire mushroom, plain mushroom, dried mushroom, plain wild rice, freeze bacterium, golden mushroom, intelligence at structure bacterium
Mushroom etc., English are：“Enoki Mushroom”.Vegetable formal name is Flammulina velutiper (Fr.) Sing, contains one kind
The substance for being Flammulin, has enhancing body to the resist ability of cancer cell, often feeding needle mushroom can also norcholesterol, prevent liver disease
Disease and intestines and stomach ulcer enhance body healthy tendency, illness prevention and fitness.Promote metabolism in vivo, is conducive to various nutrients in food
Absorption and utilization.
Technical solution of the present invention has the following advantages that：
1, the aqueous extract of the middle drug in the Chinese medicine composition provided by the invention for having weight-reducing, improving sleep is as liquid
Body culture medium, mushroom parent species liquid, needle mushroom parent species liquid carry out submerged fermentation, are sent out by deep layer in traditional Chinese medicine extyaction liquid
The mode of ferment has organically blended the effective component of mushroom parent species liquid, needle mushroom parent species liquid, by fermentation, makes the plant in Chinese medicine
Polysaccharide is closed with the animal polysaccharide in pigskin and a variety of polysaccharide Fa Sheng Suffix in mushroom and golden mushroom, in the drug for making the present invention
Object is closed containing higher amount, a greater variety of Duo Tang Suffix, effectively enhances the bioactivity of body, promotes metabolism in vivo,
Fluid dryness, immunity of organisms can be significantly increased by dying away fat, while the relatively rich sugar generated through everfermentation has
Similar nospecific immunity acts on, and induction body can actively consume body fat, and keep internal blood flow unimpeded, and comfortable body and mind promotees
It sleeps into body, and adverse reaction is reduced to adapt to the treatment requirement of the complicated state of an illness using the collaboration of drug or resistant function,
It is significant in efficacy, it securely and reliably, takes simply, has preferable therapeutic effect to improving sleep and weight-reducing.
2, the Chinese medicine composition provided by the invention for having weight-reducing, improving sleep is shown through clinical trial statistical data, right
In patient, on the one hand, there is notable curative effect, fat development can be slowed down in time, happy body and mind promotes sleep, nontoxic pair to make
With, it is on the other hand, easy to use, patient's immunity can be improved, recurrence is reduced, significantly improves life in patients.
3, the Chinese medicine aqueous extract in the Chinese medicine composition provided by the invention for having weight-reducing, improving sleep passes through and perfume (or spice)
Mushroom, needle mushroom submerged fermentation can effectively weaken some toxic side effects of Chinese medicine, keep drug effect more mild, and curative effect is thorough, energy
The crowd enough adapted to is broader.
4, the Chinese medicine composition provided by the invention that there is weight-reducing, improve sleep by fermentation, make polysaccharide in Chinese medicine with
A variety of polysaccharide Fa Sheng Suffix of animal polysaccharide and mushroom, needle mushroom in pigskin are closed, and make to contain containing higher in the drug of the present invention
Amount, a greater variety of Duo Tang Suffix close object, can significantly increase immunity of organisms, improve microcirculation, and metabolism, lipid-loweringing is accelerated to subtract
Fertilizer promotes sleep.Have similar nospecific immunity effect, induction body recovery normal through the relatively rich sugar that everfermentation generates
Function.
Specific implementation mode
It is to preferably further understand the present invention to provide following embodiments, it is not limited to the best embodiment party
Formula is not construed as limiting present disclosure and protection domain, anyone under the inspiration of the present invention or by the present invention and its
The feature of his prior art be combined and obtain it is any with the present invention it is same or similar as product, all fall within the present invention
Within protection domain.
Specific experiment step or condition person are not specified in embodiment, according to routine experiment described in document in the art
The operation of step or condition can carry out.Reagents or instruments used without specified manufacturer, being can be by acquisition purchased in market
Conventional reagent product.
One, material：
Mushroom test tube stock：Purchased from Chinese agriculture Microbiological Culture Collection administrative center, deposit number：50170, specification：
Test tube slant kind (test tube specification 18mm × 180mm, about 40 milliliters).The bacterium described in the buy or prior art it is other
Bacterial strain is also applied for the present invention.Also there is preservation in the parent species, applicant laboratory, and are prepared into test tube mycelia parent species, from application
It rises day to provide to the public for 20 years and is used for experimental study.
Needle mushroom test tube stock：Purchased from Chinese agriculture Microbiological Culture Collection administrative center, 50007 specification of deposit number：
Test tube slant kind (test tube specification 18mm × 180mm, about 40 milliliters).Its described in the buy or prior art
Its Strains of Flammulina velutipes is also suitable the present invention.Applicant laboratory also has and also has preservation, and is prepared into test tube mycelia parent species, from application
It rises day to provide to the public for 20 years and is used for experimental study.
Chinese medicine material medicine is commercially available in general Chinese medicine pharmacy.
Two, hydrogen-rich water：Day field day inland waters.
Three, equipment：
Super-pressure pot：DEPCOA-500, using ultra-high pressure sterilization technology (Ultra-highpressur
), eprocessing abbreviation UHP；High pressure processing of food technology (highpressure processing).Fermentation tank：For patent
Number 03270560.3, described in the utility model patent of entitled " cover and culture tank of vaccine culturing-pot for edible "
Fermentation tank.
Syringe：Patent No. 200320126960.X, entitled " edible fungus liquid injection rod and the note comprising the injection rod
Syringe described in the utility model patent of emitter ".
Four：Prepare parent species liquid：
1) magnesium sulfate 20g, dipotassium hydrogen phosphate 45g, potassium dihydrogen phosphate 52g, sucrose 250g are added in 18L hydrogen-rich waters, forms sediment
Powder 240g, it is fluid nutrient medium 1 to add hydrogen-rich water to be settled to 20L.
2) fluid nutrient medium 1 is injected in 500ml vials, every bottle of 400ml, one there are 50 bottles, be placed in portable pressure cooker
Inherent 0.012MP/cm2,30min take out postcooling to 28 DEG C~34 DEG C, are put into superclean bench, fluid nutrient medium is made.
3) tool, vessel and fluid nutrient medium are put into superclean bench, 50% is filled with the merging of 30g potassium permanganate
In the vessel of formalin 30ml, hook, rake, needle, the knife of inoculation are put into the vessel 30min that sterilizes.
4) by parent species in test tube, 3 parts are cut into, every part is respectively connected in 400ml/ bottles of fluid nutrient medium, stands 120min-
150min。
5) it is vibrated 72-96 hours, microscopy is without miscellaneous bacteria to get parent species liquid with 20 times/min on shaking table.
Embodiment 1-4.
Proportioned bulk pharmaceutical chemicals 1：
Embodiment 1：10 parts of campanulaceae, 20 parts of purslane, 13 parts of mulberry fruit, 17 parts of oyster, 21 parts of beauty Jiao Gen, 80 weight of balsam pear
Measure part, 5 parts of lotus leaf, 61 grams of pigskin, 150 parts of seaweed, 20 parts of luffa；
Embodiment 2：25 parts of campanulaceae, 15 parts of purslane, 9 parts of mulberry fruit, 22 parts of oyster, 15 parts of beauty Jiao Gen, 95 weight of balsam pear
Measure part, 4 parts of lotus leaf, 80 grams of pigskin, 70 parts of seaweed, 10 parts of luffa；
Embodiment 3：13 parts of campanulaceae, 18 parts of purslane, 15 parts of mulberry fruit, 15 parts of oyster, 15-30 parts of beauty Jiao Gen, balsam pear
105 parts by weight, 3 parts of lotus leaf, 50 grams of pigskin, 80 parts of seaweed, 13 parts of luffa；
Embodiment 4：20 parts of campanulaceae, 25 parts of purslane, 5 parts of mulberry fruit, 28 parts of oyster, 30 parts of beauty Jiao Gen, 85 weight of balsam pear
Measure part, 5 parts of lotus leaf, 72 grams of pigskin, 130 parts of seaweed, 17 parts of luffa
Step 1. water is inactivated 10 minutes under 30 DEG C, 600mpa environment using super-pressure pot, is passed through for wherein 40 liters after the completion
Aseptic silica gel pipeline injects spare in sterile fermentation tank.
Step 2. extracts the aqueous extract of Chinese medicine：
Proportioned bulk pharmaceutical chemicals 1 are mounted in 100 mesh filter screens, and water and proportioned bulk pharmaceutical chemicals, weight is added in super-pressure pot
Than being 3-6 for weight ratio：1 (what is selected in the present embodiment is 4:1, actually 3-6:1 can realize the goal of the invention of the present invention)；
It is handled 30 minutes under 30 DEG C, 800mpa environment, extracts Chinese medicine stoste.
Step 3:Common fermentation
During the ready fermentation for having been injected into 40 liters of hydrogen-rich waters of the aqueous extract injection step 1 for extracting Chinese medicine is filled.Again according to
Secondary injection mushroom parent species liquid, needle mushroom each 7 liters of parent species ferment.Fermentation time to be 72 hours when, detect effective solid
Object, content put tank and stop fermentation when reaching 80g/L or more.
Step 4. concentrates：It after putting tank, filters, granule is made after filter residue and drying, soup peptone or concentration is made after filtrate inactivation
Pulvis is made in crystallization.
Above-mentioned soup peptone or pulvis brew or make other food such as nutrient powder, congee with common process, and mush etc. is suitable for losing
Dormancy and obese patient eat the food containing the above-mentioned soup peptones of 2-6.10g or pulvis daily.
Experimental example 1.
1, experiment purpose
The effect of reducing blood lipid, the weight-reducing of research product of the present invention.
2, experimental method
2.1 laboratory apparatus and material
7020 full-automatic biochemical detector of Hitachi.
2.2 experimental design
360 hyperlipemic patients are selected, are divided into 4 groups, every group of 90 people, the product for using embodiment 1-4 to prepare respectively；It excludes
Following patient：(1) malignant disease is suffered from, such as tumour, severe cardiac, liver, kidney diaseases；Thyroid disease；(2) experiment starts first 1
Fat-reducing medicament is once taken in month.
During experiment, subject keeps diet and living habit unlimited as possible, cannot take fat-reducing medicament.
By above-mentioned 360 subjects, early, middle and late half an hour after meal takes tested products of the present invention daily.Continuously take 3
The course for the treatment of, two ten days as a course for the treatment of, remaining time not dietary restriction does not change lifestyles.
The effect of each group is evaluated in this experiment using patient's Self-control method.
2.3 Testing index
Before the experiment with experiment at the end of, each group detects following body index：Total cholesterol, triglycerides, height
Density cholesterol, low density cholesterol.
The variation of any biochemical indicator of the front and back own control of patient's experiment is denoted as effectively more than 1%, is denoted as more than 5% aobvious
Effect, it is invalid to be denoted as less than 1%.
3, experimental result
The results are shown in Table 1 for the specific experiment of each group.
1 reducing blood lipid of table, weight-reducing experiment result
| Embodiment | Number of cases | Effective number of cases | Effective number of cases | Invalid number of cases | Total effective rate (%) |
| 1 | 90 | 11 | 69 | 10 | 88.9 |
| 2 | 90 | 12 | 68 | 10 | 88.9 |
| 3 | 90 | 12 | 69 | 9 | 90 |
| 4 | 90 | 13 | 68 | 9 | 90 |
As shown in Table 1：Health food of the present invention improves significantly to reducing blood lipid, obesity.
4, experiment conclusion
The product of the present invention has the function of significant reducing blood lipid and weight-reducing.
Experimental example 2.
1, experiment purpose
The clinical efficacy of the improvement sleep of research product of the present invention
2, experimental method
2.1 experimental design
It is research object to randomly select 450 insomniacs, wherein man 328, female 122 is age 35-69 Sui, average
45 years old.
Insomniac is divided into 5 groups, first group, second group, third group, the 4th group and the 5th group, every group of 90 people, wherein
One group take embodiment 1 preparation granule, second group take the congee of the pulvis prepared added with embodiment 2, third group is taken
The soup peptone of the preparation of embodiment 3, the 4th group of pulvis for taking the preparation of embodiment 4 brew, and the 5th group is taken simultaneously for negative control group
Placebo (the brown sugar wine of the identical number of degrees)；It continuously takes respectively, ten days are 1 course for the treatment of, treat 3 courses for the treatment of, remaining time is unlimited
Diet processed, does not change lifestyles.
2.2 diagnostic criteria：
Safety indexes：General physical examination：Blood pressure, blood, urine, feces routine test；Liver and kidney function detects；ECG examination；Chest
Thoroughly (only before test-meal)；Abdominal B-scan ultrasonography (only before test-meal).Physical examination is primary respectively before test-meal and after test-meal, to check the safety of tested material
Property.
Efficiency index：
(1) it is almost only symptom with sleep disturbance, other symptoms are secondary to insomnia, including have difficulty in going to sleep, sleep
Not depth, Yi Xing, dreaminess, early awakening, wake up after be not easy to sleep again, wake up after feel uncomfortable, tired or daytime sleepiness.
(2) above-mentioned sleep disturbance at least occurs three times weekly, and continues one month or more.
(3) insomnia causes significant worries or cerebration efficiency to decline, or interferes social function.
(4) be not any type physical disease or phrenoblabia symptom a part.
2.3 efficacy assessment standard：
It cures：Depth of sleep, sleep speed, sleeping time restore normal person；
It is effective：Depth of sleep, sleep speed are obviously improved, sleeping time increases more than 2 hours persons；
Progress：Depth of sleep, sleep speed make moderate progress, sleeping time increases more than 1 hour person and originally takes hypnotic
It just falls asleep, the patient of medication can be not required to after treatment；
In vain：The asymptomatic improver after treatment.
3, experimental result：
Physical examination result is shown before test-meal and after test-meal：Inventive article has good tolerance, without side-effects；
Index is as shown in table 2 before test-meal and after test-meal the effect of the improvement sleep of each group.
Table 2 improves sleep experiments result
| Group | Number of cases | Effective number of cases | Effective number of cases | Invalid number of cases | Total effective rate (%) |
| First group | 90 | 17 | 69 | 4 | 95.6 |
| Second group | 90 | 13 | 70 | 7 | 92.2 |
| Third group | 90 | 18 | 69 | 3 | 96.7 |
| 4th group | 90 | 17 | 68 | 5 | 94.4 |
| 5th group | 90 | 11 | 61 | 18 | 80 |
As shown in Table 2：Product provided by the invention is with obvious effects better than control group in terms of improving sleep.
4, experiment conclusion
Product provided by the invention has the function of improving sleep well, and patient has no apparent bad anti-in experiment
It answers, clinical application safety, and recurrence rate is very low after patient profiles' improvement.
Model case：
1, Mrs She 45 years old, has suffered from insomnia 6 years, with malaise, has a pain in the back.Informal dress is stable daily
2.5mg is only capable of sleep 2~3 hours every night, preferably when sleep 4 hours.It, every night can be light after taking three courses for the treatment of of inventive article
Easily fall asleep.
2, Mr. Luo, 48 years old, insomniac more than 10 years, per hypnotic sleep is taken day by day, dosage was intrazepam daily two
Piece.After taking three courses for the treatment of of inventive article, it can fall asleep easily every night.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or
It changes still within the protection scope of the invention.
Claims (9)
1. a kind of Chinese medicine composition that there is weight-reducing, improve sleep, it is characterised in that：
It is that aqueous extract and the mushroom of following bulk pharmaceutical chemicals, the parent species liquid of needle mushroom carry out product obtained by common fermentation；
The bulk pharmaceutical chemicals have following weight：10-25 parts of campanulaceae, 15-25 parts of purslane, 5-15 parts of mulberry fruit, oyster
15-28 parts, 15-30 parts of beauty Jiao Gen, 80~100 parts by weight of balsam pear, 3-5 parts of lotus leaf, 50-80 grams of pigskin, 70-150 parts of seaweed,
10-20 parts of luffa.
2. Chinese medicine composition according to claim 1, it is characterised in that：The aqueous extract of the bulk pharmaceutical chemicals is to use hydrogen-rich
Water is Extraction solvent.
3. Chinese medicine composition according to claim 2, it is characterised in that：Selected from following any group of weight：
10 parts of campanulaceae, 20 parts of purslane, 13 parts of mulberry fruit, 17 parts of oyster, 21 parts of beauty Jiao Gen, 80 parts by weight of balsam pear, lotus leaf 5
Part, 61 grams of pigskin, 150 parts of seaweed, 20 parts of luffa；
25 parts of campanulaceae, 15 parts of purslane, 9 parts of mulberry fruit, 22 parts of oyster, 15 parts of beauty Jiao Gen, 95 parts by weight of balsam pear, 4 parts of lotus leaf,
80 grams of pigskin, 70 parts of seaweed, 10 parts of luffa；
13 parts of campanulaceae, 18 parts of purslane, 15 parts of mulberry fruit, 15 parts of oyster, 15-30 parts of beauty Jiao Gen, 105 parts by weight of balsam pear, lotus
3 parts of leaf, 50 grams of pigskin, 80 parts of seaweed, 13 parts of luffa；
20 parts of campanulaceae, 25 parts of purslane, 5 parts of mulberry fruit, 28 parts of oyster, 30 parts of beauty Jiao Gen, 85 parts by weight of balsam pear, 5 parts of lotus leaf,
72 grams of pigskin, 130 parts of seaweed, 17 parts of luffa.
4. Chinese medicine composition according to claim 3, it is characterised in that：The mushroom parent species liquid and the needle mushroom
Parent species liquid is the solution inoculum test tube stock culture gained prepared with 20L hydrogen-rich waters and auxiliary material；
The weight of the raw material of the auxiliary material is：Magnesium sulfate 20g, dipotassium hydrogen phosphate 45g, potassium dihydrogen phosphate 52g, sucrose
250g, starch 240g.
5. including the product of any Chinese medicine compositions that there is weight-reducing, improve sleep of claim 1-4.
6. the preparation method of any Chinese medicine compositions for having weight-reducing, improving sleep of claim 1-4, feature exist
In including the following steps：
(1) aqueous extract of bulk pharmaceutical chemicals is prepared；
(2) aqueous extract of bulk pharmaceutical chemicals carries out common fermentation with mushroom parent species liquid, needle mushroom parent species liquid and obtains tunning；
The extraction process of the aqueous extract of the bulk pharmaceutical chemicals is as follows：In extraction vessel, water and bulk pharmaceutical chemicals are added；Water and the original
Material medicine weight ratio is 3-6:1, the water extraction for obtaining the bulk pharmaceutical chemicals in 30-50 minutes is extracted under 25-35 DEG C, 800mpa environment
Liquid.
7. preparation method according to claim 6, it is characterised in that：The progress common fermentation refers to being pressed in fermentation tank
30-50:30-50:5-10:Aqueous extract, water, mushroom parent species liquid, the needle mushroom that the bulk pharmaceutical chemicals are added in the volume ratio of 5-10 are female
Kind liquid.
8. preparation method according to claim 8, it is characterised in that：The water uses hydrogen-rich water.
9. according to any preparation methods of claim 6-9, it is characterised in that：The fermentation refers to that effective solid is arrived in fermentation
Object content puts tank when reaching 80g/L.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091228A (en) * | 2011-03-18 | 2011-06-15 | 彭都 | Medicine for treating insomnia and preparation method thereof |
| CN107898920A (en) * | 2017-11-22 | 2018-04-13 | 中山市择朋生物科技有限公司 | A kind of mouth containing product and preparation method for diabetes |
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2018
- 2018-05-24 CN CN201810509981.0A patent/CN108403877A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091228A (en) * | 2011-03-18 | 2011-06-15 | 彭都 | Medicine for treating insomnia and preparation method thereof |
| CN107898920A (en) * | 2017-11-22 | 2018-04-13 | 中山市择朋生物科技有限公司 | A kind of mouth containing product and preparation method for diabetes |
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Application publication date: 20180817 |