CN108403620A - A kind of gelling agent of antibacterial vaginal bacteria - Google Patents
A kind of gelling agent of antibacterial vaginal bacteria Download PDFInfo
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- CN108403620A CN108403620A CN201810334671.XA CN201810334671A CN108403620A CN 108403620 A CN108403620 A CN 108403620A CN 201810334671 A CN201810334671 A CN 201810334671A CN 108403620 A CN108403620 A CN 108403620A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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Abstract
The present invention provides a kind of gelling agent of antibacterial vaginal bacteria, is made of following raw material：Gelatin, oligoisomaltose, purified water, bark of tree of heaven, the tuber of stemona, borneol, curcuma zedoary, compared with prior art, the present invention have following advantageous effect：Not only it can stop blooding, and promote wound healing but also with high-efficiency antimicrobial, bacteriostasis property, bio-safety is nontoxic, performance is stablized, there is therapeutic effect to gynecological diseases such as vaginitis (bacterial vaginosis BV, monilial vaginitis, Combination vaginitis, vulvitis) and cervical erosion, and cleanable nursing female private part, hemostasis and pain-relieving, anti-inflammatory are antibacterial and wound healing acts on.
Description
Technical field
The present invention is a kind of gelling agent of antibacterial vaginal bacteria, belongs to pharmaceutical preparations technology field.
Background technology
Vaginitis, pelvic infecton, cervicitis, cervix erosion in gynaecological disease are a kind of common disease and frequently-occurring disease, seriously
Threaten women's health.Due to the particularity of female sex organ, gynaecological imflammation has become common, the frequently-occurring disease of adult female,
Its clinical manifestation is varied, and the cause of disease is complicated and is often accompanied by a variety of severe complications, has very big shadow to the live and work of women
It rings.Vaginitis is the general name of a variety of vagina mucosa diseases caused by different pathogeny.In normal physiological condition, vagina is due to dissection
, there is natural defense function in the characteristics of tissue to the intrusion of pathogen, and when vagina natural defense function is destroyed, pathogen is easy
It invades and leads to that colpitis occurs.There are suppository in treatment method, drug to set the drug treatment of these gynecological diseases at present
It cannot be reached in vagina pleat in the drug of intravaginal, but suppository row, cannot comprehensively play the role of drug anti-inflammatory treatment.
Invention content
In view of the deficienciess of the prior art, it is an object of the present invention to provide a kind of gelling agent of antibacterial vaginal bacteria, with solution
Certainly the problems mentioned above in the background art.
To achieve the goals above, the present invention is to realize by the following technical solutions：A kind of antibacterial vaginal bacteria
Gelling agent is made of following raw material：Gelatin, oligoisomaltose, purified water, bark of tree of heaven, the tuber of stemona, borneol, curcuma zedoary.
Further, the ox-hide sulfidising solution of 5% milk of lime or 0.5~l% is impregnated, hair is sloughed, people 1% or so is put
Limewash in impregnate 1~2d, be then cut into small skin bit, small skin bit and water be added continuously in waterpower grease removal machine, water is utilized
The skin bit of degreasing is put into impregnating bath by the mechanism of the percussion and high speed iron hammer of power, cleaning except fat and dirt, is used
The ratio of 2~4% lime water retting, wet skin and water is 1：3~4, pH value is 12.0~12.5, and temperature is in 15 DEG C, time
15-90d is pulled out and is fully washed with water after skin bit expansion, and by repeatedly washing, last pH is 9.0~9.5, after washing, is used
Acid neutralizes remaining lime, and Xian Jiashui makes raw material submerge, and under constant stirring, pH is adjusted with 6mol/LHCI, is 2.5-3.5, often
A pH value is adjusted every certain time acid adding, no longer acid adding can make its balance after gelatin bone meal 8h, after neutralization, waste acid water is discharged,
It is eluted with water in the case where being sufficiently stirred, forms raw material, hot water is put into glue pot, then pours into raw material, it is to slowly warm up to 55~
65 DEG C, glue juice is released after 6~8h of hot dipping, then hot water is added into pot, 5~100C of the more previous raising of water temperature is made to continue to endure glue, according to
This analogizes, and carries out repeatedly, each temperature is also correspondingly stepped up, and can be boiled for the last time, by the dilute glue juice of gained in 600C
Left and right filter cotton, activated carbon or diatomaceous earth as filter aid, are filtered with plate and frame type filter-press, obtain clarification glue, glue again with from
Scheming detaches, and further removes the impurity such as degreasing, then dilute glue is put into and is concentrated under reduced pressure in tank, and 65~700C of control temperature is carried out
It is concentrated by evaporation, when glue thickens, 60~65 DEG C can be changed to and continue to be concentrated under reduced pressure, ultimately form the gelatin in raw material.
Further, the leaf for taking feverfew Blumea balsamifera obtains crystallization Chinese mugwort powder, then the powder that will end through steam distillation, cooling
It is refined, obtain the borneol in raw material.
Further, the rhizome for taking zingiberaceous plant curcuma zedoary shines to when doing very likely in natural light, is bundled into wisp, then dry,
It is placed on dry place's storage after drying, is put into pulverizer and crushes, smashes it through 100 mesh and sieves, sieves to obtain curcuma zedoary in raw material.
Further, using dried glucose syrup made from starch as substrate, former times enzymatic is turned by a- glucose and is occurred,
One glucosyl group transfer reaction obtains the oligoisomaltose in raw material.
Beneficial effects of the present invention：A kind of gelling agent of antibacterial vaginal bacteria of the present invention, can both stop blooding, promote wound
Again with high-efficiency antimicrobial, bacteriostasis property, bio-safety is nontoxic for healing, and performance is stablized, to vaginitis (bacterial vaginosis BV, beads
Bacterium property vaginitis, Combination vaginitis, vulvitis) and the gynecological diseases such as cervical erosion there is therapeutic effect, and cleanable shield
Reason female private part, hemostasis and pain-relieving, anti-inflammatory is antibacterial and wound healing acts on.
Specific implementation mode
To make the technical means, the creative features, the aims and the efficiencies achieved by the present invention be easy to understand, with reference to
Specific implementation mode, the present invention is further explained.
The present invention provides a kind of technical solution：A kind of gelling agent of antibacterial vaginal bacteria, is made of following raw material：Gelatin,
Oligoisomaltose, purified water, bark of tree of heaven, the tuber of stemona, borneol, curcuma zedoary.
The ox-hide sulfidising solution of 5% milk of lime or 0.5~l% is impregnated, hair is sloughed, in the limewash for putting people 1% or so
1~2d is impregnated, small skin bit is then cut into, small skin bit and water are added continuously in waterpower grease removal machine, is made using the impact of waterpower
With the mechanism with high speed iron hammer, the skin bit of degreasing is put into impregnating bath, except fat and dirt with 2~4% stone by cleaning
The ratio of grey water retting, wet skin and water is 1：3~4, pH value is 12.0~12.5, and temperature waits for skin in 15 DEG C, time 15-90d
It after block expansion, pulls out and is fully washed with water, by repeatedly washing, last pH is 9.0~9.5, after washing, is neutralized with acid remaining
Lime, Xian Jiashui makes raw material submerge, and under constant stirring, pH is adjusted with 6mol/LHCI, is 2.5-3.5, at regular intervals
Acid adding adjusts a pH value, no longer acid adding can make its balance after gelatin bone meal 8h, after neutralization, waste acid water is discharged, is being sufficiently stirred
Under be eluted with water, formed raw material, hot water is put into glue pot, then pours into raw material, is to slowly warm up to 55~65 DEG C, hot dipping 6
Glue juice is released after~8h, then hot water is added into pot, and 5~100C of the more previous raising of water temperature is made to continue to endure glue, and so on, it carries out
Repeatedly, each temperature is also correspondingly stepped up, and can be boiled for the last time, by the dilute glue juice of gained in 600C or so filterings
Cotton, activated carbon or diatomaceous earth as filter aid, are filtered with plate and frame type filter-press, obtain clarification glue, and glue is detached with centrifuge again, into
One step is except impurity such as degreasings, then dilute glue is put into and is concentrated under reduced pressure in tank, and control 65~700C of temperature is evaporated concentration, when
When glue thickens, 60~65 DEG C can be changed to and continue to be concentrated under reduced pressure, ultimately form the gelatin in raw material.
The leaf for taking feverfew Blumea balsamifera obtains crystallization Chinese mugwort powder, then Chinese mugwort powder is refined, obtains through steam distillation, cooling
Borneol in raw material.
The rhizome for taking zingiberaceous plant curcuma zedoary shines to when doing very likely in natural light, is bundled into wisp, then dry, is put after drying
It sets and is stored at drying, be put into pulverizer and crush, smash it through 100 mesh sieve, sieve to obtain curcuma zedoary in raw material.
Using dried glucose syrup made from starch as substrate, former times enzymatic is turned by a- glucose and is occurred, a glucose
The oligoisomaltose in raw material is obtained by the reaction in group-transfer.
As an embodiment of the present invention：A kind of gelling agent of antibacterial vaginal bacteria of the present invention, can both stop blooding, promote
There is high-efficiency antimicrobial, bacteriostasis property again into wound healing, bio-safety is nontoxic, and performance is stablized, to vaginitis (bacterial vaginosis
Disease, monilial vaginitis, Combination vaginitis, vulvitis) and the gynecological diseases such as cervical erosion there is therapeutic effect, and can
Cleaning-nursing female private part, hemostasis and pain-relieving, anti-inflammatory is antibacterial and wound healing acts on.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention, for this field skill
For art personnel, it is clear that invention is not limited to the details of the above exemplary embodiments, and without departing substantially from the present invention spirit or
In the case of essential characteristic, the present invention can be realized in other specific forms.Therefore, in all respects, should all incite somebody to action
Embodiment regards exemplary as, and is non-limiting, the scope of the present invention by appended claims rather than on state
Bright restriction, it is intended that including all changes that come within the meaning and range of equivalency of the claims in the present invention
It is interior.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiment being appreciated that.
Claims (5)
1. a kind of gelling agent of antibacterial vaginal bacteria, it is characterised in that：It is made of following raw material：It is gelatin, oligoisomaltose, pure
Change water, bark of tree of heaven, the tuber of stemona, borneol, curcuma zedoary.
2. a kind of gelling agent of antibacterial vaginal bacteria according to claim 1, it is characterised in that：By 5% milk of lime of ox-hide
Or the sulfidising solution of 0.5~l% impregnates, and hair is sloughed, and puts 1~2d of dipping in the limewash of people 1% or so, is then cut into cuticle
Small skin bit and water are added continuously in waterpower grease removal machine by block, using the mechanism of the percussion and high speed iron hammer of waterpower,
The skin bit of degreasing is put into impregnating bath, except fat and dirt with 2~4% lime water retting, the ratio of wet skin and water by cleaning
It is 1：3~4, pH value is 12.0~12.5, and temperature after skin bit expansion, is pulled out and fully washed with water at 15 DEG C, time 15-90d
It washs, by repeatedly washing, last pH is 9.0~9.5, and after washing, remaining lime is neutralized with acid, and Xian Jiashui makes raw material submerge,
Under constant stirring, pH is adjusted with 6mol/LHCI, is 2.5-3.5, acid adding adjusts a pH value, gelatin bone at regular intervals
It no longer acid adding can make its balance after powder 8h, after neutralization, waste acid water be discharged, is eluted with water in the case where being sufficiently stirred, raw material is formed, in glue
It is put into hot water in pot, then pours into raw material, 55~65 DEG C is to slowly warm up to, glue juice is released after 6~8h of hot dipping, then add into pot
Enter hot water, 5~100C of the more previous raising of water temperature made to continue to endure glue, and so on, carry out multiple, each temperature is also correspondingly gradually
It increases, can boil for the last time, by the dilute glue juice of gained in 600C or so filter cottons, activated carbon or diatomaceous earth as filter aid,
It is filtered with plate and frame type filter-press, obtains clarification glue, glue is detached with centrifuge again, further removes the impurity such as degreasing, then will be dilute
Glue, which is put into, to be concentrated under reduced pressure in tank, and control 65~700C of temperature is evaporated concentration, when glue thickens, can be changed to 60~65 DEG C
Continue to be concentrated under reduced pressure, ultimately forms the gelatin in raw material.
3. a kind of gelling agent of antibacterial vaginal bacteria according to claim 1, it is characterised in that：Take feverfew Blumea balsamifera
Leaf obtain crystallization Chinese mugwort powder, then Chinese mugwort powder is refined, obtain the borneol in raw material through steam distillation, cooling.
4. a kind of gelling agent of antibacterial vaginal bacteria according to claim 1, it is characterised in that：Take zingiberaceous plant curcuma zedoary
Rhizome shines to when doing very likely in natural light, is bundled into wisp, then dry, is placed at dry and stores after drying, be put into pulverizer
Middle crushing smashes it through 100 mesh sieve, sieves to obtain curcuma zedoary in raw material.
5. a kind of gelling agent of antibacterial vaginal bacteria according to claim 1, it is characterised in that：With highly concentrated made from starch
Degree glucose syrup is substrate, and turning former times enzymatic by a- glucose occurs, and a glucosyl group transfer reaction obtains low in raw material
Polyisomaltose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810334671.XA CN108403620A (en) | 2018-04-15 | 2018-04-15 | A kind of gelling agent of antibacterial vaginal bacteria |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810334671.XA CN108403620A (en) | 2018-04-15 | 2018-04-15 | A kind of gelling agent of antibacterial vaginal bacteria |
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| Publication Number | Publication Date |
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| CN108403620A true CN108403620A (en) | 2018-08-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810334671.XA Pending CN108403620A (en) | 2018-04-15 | 2018-04-15 | A kind of gelling agent of antibacterial vaginal bacteria |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109718343A (en) * | 2019-03-05 | 2019-05-07 | 无比滴（广东）药业有限公司 | One kind taking off scar patch |
| CN114146127A (en) * | 2021-12-09 | 2022-03-08 | 上海左耳零医疗科技有限公司 | Female bacteriostatic lotion for treating HPV (human papillomavirus) by plant compound prescription and preparation method thereof |
Citations (2)
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|---|---|---|---|---|
| CN102133170A (en) * | 2010-01-21 | 2011-07-27 | 成都利济医药器械有限公司 | Bacteriostatic gel for treating and preventing vaginitis |
| CN105535867A (en) * | 2016-02-15 | 2016-05-04 | 福建艾女人生物科技有限公司 | Antibacterial gel special for gynecology and preparation method thereof |
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2018
- 2018-04-15 CN CN201810334671.XA patent/CN108403620A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133170A (en) * | 2010-01-21 | 2011-07-27 | 成都利济医药器械有限公司 | Bacteriostatic gel for treating and preventing vaginitis |
| CN105535867A (en) * | 2016-02-15 | 2016-05-04 | 福建艾女人生物科技有限公司 | Antibacterial gel special for gynecology and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109718343A (en) * | 2019-03-05 | 2019-05-07 | 无比滴（广东）药业有限公司 | One kind taking off scar patch |
| CN114146127A (en) * | 2021-12-09 | 2022-03-08 | 上海左耳零医疗科技有限公司 | Female bacteriostatic lotion for treating HPV (human papillomavirus) by plant compound prescription and preparation method thereof |
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Application publication date: 20180817 |