CN108403569A - A kind of preparation method for removing acne print gel - Google Patents
A kind of preparation method for removing acne print gel Download PDFInfo
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
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- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A61K8/9783—Angiosperms [Magnoliophyta]
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Abstract
A kind of preparation method for removing acne print gel, belongs to cosmetic technical field.Specific preparation process is as follows：It pulverizes after extracting liquorice, chamomile, ursin, mulberries, aloe and Sodium Ascorbyl Phosphate mixing；Then alcohol solution dipping is added into powder, then carries out ultrasonic disperse；By mixed liquor heating water bath postcooling after dispersion to room temperature；Then vitamin C, salicylic acid, tussol, niacinamide, aluminium-magnesium silicate, dipotassium glycyrrhizinate and hydroxy acetophenone mixing is added；After stirring in mixture input vacuum emulsification pot, vacuumizes and equal qualitative response occurs, then discharge after deflation vacuum breaker, packed after sterilizing.Preparation method of the present invention is simple for process, and raw material is easy to get, and product obtained is quick, goes acne print effect good.The anti-acne print gel of preparation has the effect of complex treatment simultaneously a variety of (improving pore, desalination acne print, beautiful skin U.S. face), and clinical trial cure rate is up to 85% or more.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of preparation method for removing acne print gel.
Background technology
Pockmark is body reacts a kind of reparation that tissue damage generates, when the damage depth and corium or large area of skin
The epidermis of skin blemish, the position cannot regenerate, will be by corium fabric cell, and the blood vessel of collagen and hyperplasia is replaced, in this way
There have been pockmarks.Pockmark is because infection inflammation or external force extruding are formed, often because not having when whelk is broken out
Timely treatment appropriate is obtained, the inflammatory response of Skin Cell causes the destruction to skin histology, causes the generation of scar.
Since the type of whelk is of all kinds, so the form of youth pockmark also has a lot of kinds, and inflammation when whelk breaking-out is anti-
Should be more serious, skin histology also destroys more severe；The position of inflammation is deeper, and skin histology is destroyed also deeper, in the future may be used
The pockmark that can be left is also more serious.
Blood vessel can't contract down at once after small pox causes blood vessel dilatation, small pox to disappear down when breaking out, and be formed
Average red erythema, and the inflammatory response of Skin Cell causes the destruction to skin histology, the pigementation meeting after inflammation
The place for growing red small pox is set to leave black dirty color, material is thus formed acne prints；And when to continue acne print also continuous for small pox
When increasing, various cells release cytokine profiles, cause skin collagen and matrix to arrange abnormal, add microcirculation
With the influence of free axoneme, lymphatic return is reduced, and local edema, which forms acne scar pockmarks.Have for acne print and acne scar
A variety of therapies, they are each advantageous, also have the shortcomings that apparent, and physical therapy is quick, however somewhat expensive, surgical pain,
It operation and subsequently nurses improper, easily causes further pigmentation.Chemotherapy safety is shown in respect to physical therapy height
Effect is slow, produces effects slow, consumer is difficult to accept.
Invention content
The technical issues of solution：In view of the above technical problems, the present invention provides a kind of preparation method for removing acne print gel, tool
Prepare that standby product is quick, has no toxic side effect, the advantages that using effect is good.
Technical solution：A kind of preparation method for removing acne print gel, the preparation method comprises the following steps：
Step 1 takes 12~14 mass parts Radix Glycyrrhizaes, 3~8 mass parts chamomiles, 4~8 mass parts ursin, 1.5~3 matter
Amount part mulberries, 8~13 mass parts aloes and 1~3 mass parts Sodium Ascorbyl Phosphate are put into grinder grind after mixing
It is milled to 100~120 mesh；
80~95 mass parts 75wt.% ethanol solutions are added into powder after grinding by step 2, impregnate 3~5h under room temperature,
Then 20~30min of ultrasonic disperse under 20kHz~33kHz frequencies；
Mixed liquor after ultrasonic disperse is heated 40~55min in 70~89 DEG C of water-baths and then cooled to room temperature by step 3；
0.5~1.2 mass parts vitamin C, 0.2~0.8 mass parts are added into the mixed liquor being cooled to room temperature by step 4
Salicylic acid, 0.3~0.6 mass parts tussol, 1~3 mass parts niacinamide, 1~2.5 mass parts aluminium-magnesium silicate, 2~4 mass parts
Dipotassium glycyrrhizinate and 3~5 mass parts hydroxy acetophenones stir 20~30min at a temperature of 33~45 DEG C with 100~250r/min；
After step 5 will be stirred in mixture input vacuum emulsification pot, it is evacuated to -0.05~-0.03MPa, 1000
Then 10~20min of homogeneous under~1200r/min rotating speeds discharges after deflation vacuum breaker, is packed after sterilizing, institute is finally made
State acne print gel.
Preferably, taking 13 mass parts Radix Glycyrrhizaes, 5 mass parts chamomiles, 6 mass parts ursin, 2 mass in the step 1
Part mulberries, 10 mass parts aloes and 2 mass parts Sodium Ascorbyl Phosphate are put into grinder are ground to 120 after mixing
Mesh.
Preferably, 90 mass parts 75wt.% ethanol solutions are added in the step 2 into powder after grinding, under room temperature
4h is impregnated, then the ultrasonic disperse 25min under 28kHz frequencies.
Preferably, mixed liquor after ultrasonic disperse to be heated to 50min then coolings in the step 3 in 80 DEG C of water-baths
To room temperature.
Preferably, 0.9 mass parts vitamin C, 0.6 matter is added in the step 4 into the mixed liquor being cooled to room temperature
Measure part salicylic acid, 0.5 mass parts tussol, 2 mass parts niacinamide, 2 mass parts aluminium-magnesium silicates, 3 mass parts dipotassium glycyrrhizinates and 4
Mass parts hydroxy acetophenone stirs 25min at a temperature of 40 DEG C with 200r/min.
Preferably, it will be evacuated to -0.04MPa in mixture input vacuum emulsification pot after being stirred in the step 5,
Then the homogeneous 15min under 1100r/min rotating speeds discharges after deflation vacuum breaker, is packed after sterilizing, be finally made described and go
Acne print gel.
Advantageous effect：Preparation method of the present invention is simple for process, and raw material is easy to get, and product obtained is quick, goes acne print
Effect is good.The present invention by adding mulberries and niacinamide, with Radix Glycyrrhizae, chamomile, ursin, aloe, Sodium Ascorbyl Phosphate,
Vitamin C, salicylic acid, tussol, aluminium-magnesium silicate, dipotassium glycyrrhizinate and hydroxy acetophenone mixing, play synergistic effect,
So that the anti-acne print gel prepared has the effect of complex treatment simultaneously a variety of (improving pore, desalination acne print, beautiful skin U.S. face), face
Bed tests cure rate up to 85% or more.
Specific implementation mode
Embodiment 1
A kind of preparation method for removing acne print gel, the preparation method comprises the following steps：
Step 1 takes 12 mass parts Radix Glycyrrhizaes, 3 mass parts chamomiles, 4 mass parts ursin, 1.5 mass parts mulberries, 8 mass
Part aloe and 1 mass parts Sodium Ascorbyl Phosphate are put into grinder and are ground to 100 mesh after mixing.
80 mass parts 75wt.% ethanol solutions are added into powder after grinding by step 2, impregnate 3h under room temperature, then exist
Ultrasonic disperse 20min under 20kHz frequencies.
Mixed liquor after ultrasonic disperse is heated 40min in 70 DEG C of water-baths and then cooled to room temperature by step 3.
0.5 mass parts vitamin C, 0.2 mass parts salicylic acid, 0.3 are added into the mixed liquor being cooled to room temperature by step 4
Mass parts tussol, 1 mass parts niacinamide, 1 mass parts aluminium-magnesium silicate, 2 mass parts dipotassium glycyrrhizinates and 3 mass parts hydroxy benzenes second
Ketone stirs 20min at a temperature of 33 DEG C with 100r/min.
After step 5 will be stirred in mixture input vacuum emulsification pot, it is evacuated to -0.05MPa, is turned in 1000r/min
The lower homogeneous 10min of speed, then discharges after deflation vacuum breaker, is packed after sterilizing, is finally made described and removes acne print gel.
Embodiment 2
A kind of preparation method for removing acne print gel, the preparation method comprises the following steps：
Step 1 takes 14 mass parts Radix Glycyrrhizaes, 8 mass parts chamomiles, 8 mass parts ursin, 3 mass parts mulberries, 13 mass
Part aloe and 3 mass parts Sodium Ascorbyl Phosphate are put into grinder and are ground to 120 mesh after mixing.
95 mass parts 75wt.% ethanol solutions are added into powder after grinding by step 2, impregnate 5h under room temperature, then exist
Ultrasonic disperse 30min under 33kHz frequencies.
Mixed liquor after ultrasonic disperse is heated 55min in 89 DEG C of water-baths and then cooled to room temperature by step 3.
1.2 mass parts vitamin Cs, 0.8 mass parts salicylic acid, 0.6 are added into the mixed liquor being cooled to room temperature by step 4
Mass parts tussol, 3 mass parts niacinamide, 2.5 mass parts aluminium-magnesium silicates, 4 mass parts dipotassium glycyrrhizinates and 5 mass parts hydroxy benzenes
Ethyl ketone stirs 30min at a temperature of 45 DEG C with 250r/min.
After step 5 will be stirred in mixture input vacuum emulsification pot, it is evacuated to -0.03MPa, is turned in 1200r/min
The lower homogeneous 20min of speed, then discharges after deflation vacuum breaker, is packed after sterilizing, is finally made described and removes acne print gel.
Embodiment 3
A kind of preparation method for removing acne print gel, the preparation method comprises the following steps：
Step 1 takes 13 mass parts Radix Glycyrrhizaes, 5 mass parts chamomiles, 6 mass parts ursin, 2 mass parts mulberries, 10 mass
Part aloe and 2 mass parts Sodium Ascorbyl Phosphate are put into grinder and are ground to 120 mesh after mixing.
90 mass parts 75wt.% ethanol solutions are added into powder after grinding by step 2, impregnate 4h under room temperature, then exist
Ultrasonic disperse 25min under 28kHz frequencies.
Mixed liquor after ultrasonic disperse is heated 50min in 80 DEG C of water-baths and then cooled to room temperature by step 3.
0.9 mass parts vitamin C, 0.6 mass parts salicylic acid, 0.5 are added into the mixed liquor being cooled to room temperature by step 4
Mass parts tussol, 2 mass parts niacinamide, 2 mass parts aluminium-magnesium silicates, 3 mass parts dipotassium glycyrrhizinates and 4 mass parts hydroxy benzenes second
Ketone stirs 25min at a temperature of 40 DEG C with 200r/min.
After step 5 will be stirred in mixture input vacuum emulsification pot, it is evacuated to -0.04MPa, is turned in 1100r/min
The lower homogeneous 15min of speed, then discharges after deflation vacuum breaker, is packed after sterilizing, is finally made described and removes acne print gel.
Comparative example 1
With embodiment 3, difference lies in mulberries and niacinamide are not added, specific preparation process is as follows：
Step 1 takes 13 mass parts Radix Glycyrrhizaes, 5 mass parts chamomiles, 6 mass parts ursin, 10 mass parts aloes and 2 mass
Part Sodium Ascorbyl Phosphate, which is put into after mixing in grinder, is ground to 120 mesh.
90 mass parts 75wt.% ethanol solutions are added into powder after grinding by step 2, impregnate 4h under room temperature, then exist
Ultrasonic disperse 25min under 28kHz frequencies.
Mixed liquor after ultrasonic disperse is heated 50min in 80 DEG C of water-baths and then cooled to room temperature by step 3.
0.9 mass parts vitamin C, 0.6 mass parts salicylic acid, 0.5 are added into the mixed liquor being cooled to room temperature by step 4
Mass parts tussol, 2 mass parts aluminium-magnesium silicates, 3 mass parts dipotassium glycyrrhizinates and 4 mass parts hydroxy acetophenones are at a temperature of 40 DEG C
25min is stirred with 200r/min.
After step 5 will be stirred in mixture input vacuum emulsification pot, it is evacuated to -0.04MPa, is turned in 1100r/min
The lower homogeneous 15min of speed, then discharges after deflation vacuum breaker, is packed after sterilizing, is finally made described and removes acne print gel.
Acne print gel products are gone to be tested for the property to prepared by Examples 1 to 3 and comparative example 1.In hospital dermatology department door
It examines or skin section hospital selects 80 people of patients with acne made a definite diagnosis, wherein men and women is fifty-fifty, and the age is average from 17 years old to 29 years old
22.5 years old, sick time differed for 3 months to 5 years, was divided into 4 groups, every group of 20 people, are respectively adopted Examples 1 to 3 and comparative example 1 is made
Standby removes acne print gel.The treatment of patient, take corresponding group's preparation respectively goes acne print gel 0.5g to be evenly coated in acne print, and one
It is applied 1~2 time, 15 days courses for the treatment of.Test result is observed after two courses for the treatment of.Curative effect judging standard is cured：Acne, scar or acne print are complete
It totally disappeared mistake；Effectively：Acne, scar or acne print improve but do not completely disappear, skin insentience, in vain：Acne, scar or acne print do not change
Become or aggravates.Concrete outcome is referring to following table.
| Healing/number | Effectively/number | In vain/number | |
| Embodiment 1 | 16 | 4 | 0 |
| Embodiment 2 | 15 | 5 | 0 |
| Embodiment 3 | 17 | 3 | 0 |
| Comparative example 1 | 10 | 9 | 1 |
Claims (6)
1. a kind of preparation method for removing acne print gel, which is characterized in that the preparation method comprises the following steps：
Step 1 take 12 ~ 14 mass parts Radix Glycyrrhizaes, 3 ~ 8 mass parts chamomiles, 4 ~ 8 mass parts ursin, 1.5 ~ 3 mass parts mulberries,
8 ~ 13 mass parts aloes and 1 ~ 3 mass parts Sodium Ascorbyl Phosphate are put into grinder are ground to 100 ~ 120 after mixing
Mesh；
80 ~ 95 mass parts, 75 wt.% ethanol solutions are added into powder after grinding by step 2, impregnate 3 ~ 5 h under room temperature, then
20 ~ 30 min of ultrasonic disperse under the kHz frequencies of 20 kHz ~ 33；
Mixed liquor after ultrasonic disperse is heated 40 ~ 55 min in 70 ~ 89 DEG C of water-baths and then cooled to room temperature by step 3；
0.5 ~ 1.2 mass parts vitamin C, 0.2 ~ 0.8 mass parts bigcatkin willow are added into the mixed liquor being cooled to room temperature by step 4
Acid, 0.3 ~ 0.6 mass parts tussol, 1 ~ 3 mass parts niacinamide, 1 ~ 2.5 mass parts aluminium-magnesium silicate, 2 ~ 4 mass parts glycyrrhizic acids two
Potassium and 3 ~ 5 mass parts hydroxy acetophenones stir 20 ~ 30 min at a temperature of 33 ~ 45 DEG C with 100 ~ 250 r/min；
After step 5 will be stirred in mixture input vacuum emulsification pot, it is evacuated to -0.05 ~ -0.03 MPa, 1000 ~ 1200
Then 10 ~ 20 min of homogeneous under r/min rotating speeds discharges after deflation vacuum breaker, is packed after sterilizing, be finally made described and go acne
Print gel.
2. a kind of preparation method for removing acne print gel according to claim 1, which is characterized in that take 13 in the step 1
Mass parts Radix Glycyrrhizae, 5 mass parts chamomiles, 6 mass parts ursin, 2 mass parts mulberries, 10 mass parts aloes and 2 mass parts are anti-bad
Hematic acid sodium phosphate, which is put into after mixing in grinder, is ground to 120 mesh.
3. a kind of preparation method for removing acne print gel according to claim 1, which is characterized in that grinding in the step 2
90 mass parts, 75 wt.% ethanol solutions are added after mill in powder, impregnate 4 h under room temperature, then the ultrasound point under 28 kHz frequencies
Dissipate 25 min.
4. a kind of preparation method for removing acne print gel according to claim 1, which is characterized in that will surpass in the step 3
Mixed liquor heats 50 min in 80 DEG C of water-baths and then cools to room temperature after sound dispersion.
5. a kind of preparation method for removing acne print gel according to claim 1, which is characterized in that cold in the step 4
But to 0.9 mass parts vitamin C, 0.6 mass parts salicylic acid, 0.5 mass parts tussol, 2 mass are added in the mixed liquor of room temperature
Part niacinamide, 2 mass parts aluminium-magnesium silicates, 3 mass parts dipotassium glycyrrhizinates and 4 mass parts hydroxy acetophenones at a temperature of 40 DEG C with
200 r/min stir 25 min.
6. a kind of preparation method for removing acne print gel according to claim 1, which is characterized in that will be stirred in the step 5
It mixes in rear mixture input vacuum emulsification pot, is evacuated to -0.04 MPa, 15 min of homogeneous under 1100 r/min rotating speeds, so
It discharges after deflation vacuum breaker, is packed after sterilizing afterwards, be finally made described and remove acne print gel.
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| CN201810549199.1A CN108403569A (en) | 2018-05-31 | 2018-05-31 | A kind of preparation method for removing acne print gel |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810549199.1A CN108403569A (en) | 2018-05-31 | 2018-05-31 | A kind of preparation method for removing acne print gel |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109431948A (en) * | 2019-01-18 | 2019-03-08 | 杭州颐美益生物科技有限公司 | The Chinese medicine cosmetic and preparation method of removing acne, desalination acne print, acne scar |
| CN109498471A (en) * | 2018-12-17 | 2019-03-22 | 靖西市秀美边城农业科技有限公司 | A kind of anti-acne print gel and preparation method thereof |
-
2018
- 2018-05-31 CN CN201810549199.1A patent/CN108403569A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109498471A (en) * | 2018-12-17 | 2019-03-22 | 靖西市秀美边城农业科技有限公司 | A kind of anti-acne print gel and preparation method thereof |
| CN109431948A (en) * | 2019-01-18 | 2019-03-08 | 杭州颐美益生物科技有限公司 | The Chinese medicine cosmetic and preparation method of removing acne, desalination acne print, acne scar |
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